Hub : Genes

LOC102549959

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 RMTg alternative TSS XR_001840620.3 0.49 0.17 2.8e-04 0.12 0.16 0.13 0.18 4.3e-04 6.3e-05 2.6e-04 2.0e-05
2 RMTg alternative TSS XR_005491690.2 0.33 0.17 9.4e-04 0.1 0.1 0.07 0.14 1.1e-03 1.2e-03 7.0e-03 1.8e-04
3 RMTg alternative TSS XR_001840620.3 0.19 0.11 1.7e-03 0.06 0.1 0.01 0.05 1.3e-02 1.2e-03 1.6e-01 2.0e-02
4 RMTg alternative TSS XR_005491690.2 0.17 0.11 5.0e-03 0.05 0.1 0.01 0.04 2.1e-02 1.3e-03 1.8e-01 2.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bone: apparent density3.56.48.62.9-2.92.3-1.8
Area under the delay curve1.11.62.0-1.41.4-1.21.0
BMI with tail1.13.75.52.3-2.31.7-1.1
BMI without tail2.111.114.63.8-3.82.9-2.6
Body weight9.943.550.37.1-7.16.5-5.6
Weight adjusted by age0.61.92.90.9-0.91.7-1.7
Bone surface4.28.210.33.2-3.22.7-2.2
Bone volume1.83.55.22.3-2.31.6-1.1
Breakpoint value in progressive ratio session0.10.20.30.6-0.60.4-0.4
Number of licking bursts1.34.05.41.7-1.72.2-2.3
Context. condit. distance diff. score1.11.32.41.5-1.50.7-0.4
Locomotion velocity, session 10.30.40.7-0.80.8-0.1-0.1
Locomotion distance, session 10.81.01.9-1.41.4-0.50.3
Locomotion velocity, session 20.40.51.30.1-0.10.8-1.1
Locomotion distance, session 20.40.51.2-0.30.30.8-1.1
Locomotion velocity, session 30.10.10.2-0.50.5-0.20.3
Locomotion distance, session 30.20.30.5-0.70.7-0.30.3
Stereotopy head waving bouts, day 32.02.42.71.6-1.61.5-1.4
Stereotopy head waving duration, day 30.00.00.0-0.00.1-0.10.2
Locomotion velocity, session 71.71.92.2-1.51.5-1.31.2
Locomotion distance, session 70.60.80.9-1.01.0-0.80.8
Stereotopy head waving bouts, day 70.50.50.9-1.01.0-0.50.2
Stereotopy head waving duration, day 70.60.71.2-1.11.1-0.60.3
Locomotion velocity, session 80.00.10.10.1-0.10.3-0.4
Locomotion distance, session 80.91.41.61.1-1.11.2-1.2
Degree of sensitization distance0.20.20.3-0.50.6-0.50.3
Degree of sensitization stereotypy1.21.31.9-1.41.4-1.00.8
Conditioned locomotion0.10.20.30.6-0.60.20.0
Cocaine response after cond. corrected0.71.11.9-0.70.7-1.21.4
Cocaine response after cond. not corrected1.21.82.9-1.01.0-1.51.7
Cocaine response before conditioning0.10.10.2-0.40.4-0.30.4
Saline control response4.05.56.72.1-2.12.5-2.6
Bone: connectivity density6.710.712.33.5-3.53.2-2.8
Bone: cortical apparent density0.30.40.5-0.70.7-0.60.6
Bone: cortical area1.21.92.61.6-1.61.2-0.9
Bone: cortical porosity0.00.00.1-0.30.3-0.1-0.1
Bone: cortical porosity0.20.30.4-0.60.6-0.40.2
Bone: cortical thickness1.11.92.51.6-1.61.2-1.0
Bone: cortical thickness0.81.01.21.1-1.10.9-0.8
Bone: cortical tissue density0.30.40.5-0.70.7-0.60.6
Condit. Reinf. active minus inactive responses0.10.10.20.4-0.40.1-0.0
Condit. Reinf. active-inactive response ratio0.00.00.10.1-0.1-0.20.4
Condit. Reinf. active responses0.20.30.50.7-0.70.2-0.2
Condit. Reinf. inactive responses0.00.00.00.1-0.1-0.20.1
Incentive salience index mean0.00.00.10.2-0.2-0.20.3
Condit. Reinf. lever presses0.30.50.9-0.40.4-0.91.0
Condit. Reinf. active minus inactive responses0.40.71.20.5-0.50.9-1.1
Condit. Reinf. active-inactive response ratio0.10.20.5-0.00.00.5-0.7
Condit. Reinf. active responses0.71.11.60.8-0.81.2-1.3
Condit. Reinf. inactive responses0.30.40.40.6-0.60.7-0.6
Condit. Reinf. lever presses0.00.00.00.1-0.10.2-0.0
Condit. Reinf. lever reinforcers received0.60.81.40.6-0.61.1-1.2
Conditioned reinforcement - actives0.83.43.71.9-1.91.8-1.7
Conditioned reinforcement - inactives0.00.00.0-0.10.0-0.1-0.0
Conditioned locomotion1.31.92.21.5-1.51.3-1.3
Patch foraging indifference point 0 sec0.10.10.20.5-0.50.30.0
Patch foraging indifference point AUC0.61.41.51.1-1.11.2-1.1
Delay disc. indifference point, 0s delay0.30.30.5-0.70.7-0.40.4
Delay disc. indifference point, 16s delay0.91.21.3-1.11.1-1.11.0
Delay disc. indifference point, 2s delay3.33.74.6-2.12.1-1.81.6
Delay disc. indifference point, 24s delay1.11.72.2-1.51.5-1.21.0
Delay disc. indifference point, 4s delay2.72.93.2-1.81.8-1.61.6
Delay disc. indifference point, 8s delay0.10.10.2-0.40.4-0.30.3
Indifference point function ln k0.20.60.70.7-0.70.8-0.8
Indifference point function log k0.20.60.70.7-0.70.8-0.8
Patch foraging total patch changes 0 sec0.10.20.30.6-0.60.4-0.0
Patch foraging total patch changes 12 sec0.10.20.30.6-0.60.30.1
Patch foraging total patch changes 18 sec0.00.10.20.4-0.40.10.1
Patch foraging total patch changes 24 sec0.00.10.20.5-0.50.20.1
Patch foraging total patch changes 6 sec0.10.20.40.6-0.60.4-0.1
Patch foraging time to switch 0 sec2.28.38.9-3.03.0-2.82.7
Patch foraging water rate 0 sec2.28.28.62.9-2.92.9-2.7
Patch foraging water rate 12 sec1.03.84.01.9-1.92.0-2.0
Patch foraging water rate 18 sec0.40.91.01.0-1.00.9-1.0
Patch foraging water rate 24 sec4.86.88.12.4-2.42.8-2.8
Patch foraging water rate 6 sec1.42.12.61.6-1.61.3-1.2
Seeking ratio, delayed vs. immediate footshock1.11.61.8-1.21.2-1.31.3
Distance traveled before self-admin0.81.82.0-1.31.3-1.41.4
Distance traveled after self-admin0.00.00.0-0.00.00.2-0.1
Extensor digitorum longus weight3.112.315.94.0-4.03.2-2.7
Bone: elastic displacement0.30.30.60.3-0.30.6-0.8
Bone: elastic work5.26.87.42.7-2.72.6-2.4
Bone: endosteal estimation1.53.53.61.9-1.91.9-1.9
Bone: endosteal perimeter1.12.83.81.9-1.91.4-1.2
Epididymis fat weight0.10.61.01.0-1.00.5-0.2
Delta time in closed arm before/after self-admin0.90.81.01.0-1.00.8-0.9
Delta time in open arm before/after self-admin6.17.28.3-2.92.9-2.62.4
Diff in mean of infusions in LGA sessions0.00.10.10.4-0.40.00.1
Delay discount exponential model param1.62.22.71.6-1.61.4-1.2
Extinction: sum of active levers before priming0.10.10.20.5-0.5-0.10.3
Active lever presses in extinction session 60.80.91.11.0-1.10.9-0.7
Bone: final force2.64.35.12.3-2.31.9-1.8
Bone: final moment2.43.94.52.1-2.11.9-1.7
Food consumed during 24 hour testing period0.00.00.10.1-0.10.1-0.2
Glucose0.81.31.4-1.11.1-1.21.1
Heart weight1.21.91.91.4-1.41.3-1.4
Delay discount hyperbolic model param1.72.12.61.6-1.61.3-1.2
Intermittent access intake day 1-15 change0.10.60.70.7-0.70.8-0.8
Intermittent access intake escalation0.10.30.40.5-0.50.7-0.6
Intermittent access intake escalation 20.00.00.0-0.20.2-0.10.1
Intermitt. access day 1 inactive lever presses0.00.00.1-0.10.00.2-0.3
Intermitt. access day 15 inactive lever presses0.42.42.6-1.61.6-1.51.5
Intermitt. access escalation Index0.00.00.1-0.00.00.2-0.2
Intermittent access day 1 total infusions0.10.40.6-0.80.8-0.60.4
Intermittent access day 15 total infusions0.00.00.0-0.20.20.0-0.2
Intermittent access terminal intake (last 3 days)0.10.20.3-0.50.5-0.40.2
Intermittent access total infusions0.40.50.7-0.80.8-0.70.5
Intermittent access day 1 locomotion0.40.81.0-1.01.0-0.80.6
Intermittent access day 15 total locomotion0.00.10.2-0.40.40.0-0.3
Intermittent access total locomotion0.60.71.1-1.11.0-0.70.5
Intermittent access standard deviation0.00.10.2-0.20.2-0.50.4
Left kidney weight4.536.344.36.7-6.75.7-4.9
Right kidney weight4.733.039.76.3-6.35.4-4.8
Cocaine induced anxiety0.10.20.40.0-0.0-0.50.6
Post-drug Anxiety4.45.06.1-2.02.0-2.52.4
Baseline Anxiety3.05.15.9-2.42.4-2.21.9
Tail length6.434.437.66.1-6.15.7-5.5
Length with tail12.455.057.27.5-7.67.6-7.0
Length without tail3.719.422.14.4-4.44.7-4.1
Times rat made contact with spout3.54.04.91.8-1.82.1-2.2
Lifetime Intake0.70.91.0-1.01.0-1.00.8
Liver weight, left4.27.27.82.7-2.72.8-2.5
Liver weight, right3.96.87.52.7-2.72.6-2.3
Locomotor activity2.43.83.91.9-1.92.0-2.0
Locomotor testing distance0.61.41.71.1-1.11.3-1.3
Locomotor testing rearing0.00.10.2-0.40.4-0.10.1
Locomotion in novel chamber4.25.66.52.3-2.32.3-2.6
Locomotion in novel chamber post-restriction2.47.47.92.7-2.72.7-2.8
Fecal boli incidents, locomotor time 10.41.01.70.6-0.61.2-1.3
Change in fecal boli incidents, locomotor task0.20.20.3-0.40.4-0.60.6
Time >=10cm from walls, locomotor time 11.11.41.5-1.11.1-1.21.2
Bouts of movement, locomotor time 12.33.04.22.1-2.11.4-1.2
Total resting periods, locomotor time 12.22.63.61.9-1.91.3-1.2
Rest time, locomotor task time 11.11.72.31.5-1.51.1-1.0
Distance moved, locomotor task time 10.00.00.0-0.20.2-0.1-0.0
Vertical activity count, locomotor time 10.10.91.01.0-1.00.9-0.9
Time >=10cm from walls, locomotor time 20.00.00.00.1-0.00.00.1
Bouts of movement, locomotor time 20.82.52.91.7-1.71.6-1.4
Total resting periods, locomotor time 20.52.02.71.6-1.61.3-1.1
Rest time, locomotor task time 20.20.40.9-0.20.2-0.81.0
Distance moved, locomotor task time 21.51.92.81.1-1.11.6-1.7
Vertical activity count, locomotor time 22.14.85.32.1-2.12.3-2.3
Light reinforcement 10.83.74.3-2.12.1-1.81.7
Light reinforcement 20.30.60.9-0.60.6-1.00.9
Bone: marrow area1.43.43.41.9-1.91.8-1.8
Bone: maximum diameter1.22.43.21.8-1.81.4-1.1
Bone: maximum force1.63.13.81.9-1.91.7-1.5
Bone: maximum moment1.62.93.41.8-1.81.7-1.5
Mean time between licks in bursts0.21.21.6-1.31.3-1.00.8
Mean num. licks in bursts0.10.30.4-0.30.3-0.60.6
Cd content in liver0.80.91.30.8-0.80.9-1.1
Co content in liver0.00.00.1-0.10.10.1-0.2
Cu content in liver0.30.30.30.6-0.60.6-0.5
Fe content in liver0.91.11.81.3-1.30.8-0.4
K content in liver0.50.50.6-0.70.8-0.70.7
Mg content in liver0.10.10.2-0.30.3-0.40.4
Mn content in liver0.40.50.9-1.01.0-0.2-0.0
Na content in liver0.00.00.10.2-0.20.2-0.2
Rb content in liver4.04.74.9-2.12.1-2.22.2
Se content in liver0.50.61.3-0.40.4-0.81.1
Sr content in liver1.71.51.51.2-1.21.2-1.2
Zn content in liver5.26.17.32.7-2.72.3-2.1
Bone: minimum diameter0.00.00.0-0.20.2-0.10.1
Time in familiar zone, hab. session 10.00.00.0-0.10.2-0.20.2
Time in novel zone, hab. session 10.60.60.80.7-0.70.9-0.9
Total zone transitions, hab. session 10.70.91.9-1.41.4-0.2-0.2
Total locomotion distance, hab. session 11.82.53.6-1.91.9-1.31.1
Locomotion velocity, hab. session 13.65.26.7-2.62.6-2.01.8
Time in familiar zone, hab. session 20.10.10.1-0.20.2-0.20.3
Time in novel zone, hab. session 20.10.10.1-0.30.3-0.30.2
Total zone transitions, hab. session 20.70.91.90.5-0.51.1-1.4
Total locomotion distance, hab. session 20.30.30.5-0.70.7-0.50.3
Locomotion velocity, hab. session 20.20.30.5-0.70.7-0.50.2
Novel to familiar place preference ratio0.00.10.1-0.30.3-0.1-0.1
Novelty place preference0.20.20.4-0.60.6-0.20.0
Time in novel zone, NPP test0.10.10.1-0.40.4-0.0-0.2
Total zone transitions, NPP test0.40.61.30.3-0.31.0-1.1
Total locomotion distance, NPP test0.40.60.7-0.80.8-0.80.7
Locomotion velocity, NPP test0.20.30.3-0.60.6-0.50.4
Intraocular pressure0.61.01.91.4-1.40.5-0.3
Delta distance traveled before/after self-admin0.90.91.50.7-0.71.2-1.2
Delta ambulatory time before/after self-admin0.10.20.40.0-0.00.6-0.6
Parametrial fat weight0.00.00.10.2-0.2-0.00.2
Pavlov. Cond. lever latency2.12.62.81.7-1.71.6-1.5
Pavlov. Cond. magazine entry latency0.81.01.21.1-1.10.9-1.0
Pavlov. Cond. change in total contacts0.50.50.7-0.60.6-0.80.8
Pavlov. Cond. index score0.00.10.1-0.20.2-0.30.3
Pavlov. Cond. latency score0.10.20.2-0.40.3-0.40.4
Pavlov. Cond. lever contacts2.02.42.6-1.61.6-1.61.5
Pavlov. Cond. magazine entry number0.40.50.6-0.80.8-0.70.7
Pavlov. Cond. intertrial magazine entries0.00.10.1-0.00.1-0.30.3
Pavlov. Cond. lever-magazine prob. diff.0.10.10.2-0.20.2-0.40.4
Pavlov. Cond. response bias0.10.10.10.4-0.40.2-0.2
Pavlov. Cond. lever latency0.20.20.30.5-0.50.4-0.4
Pavlov. Cond. magazine entry latency1.52.22.8-1.71.7-1.31.2
Pavlov. Cond. change in total contacts0.00.10.1-0.30.30.2-0.3
Pavlov. Cond. index score0.50.81.1-1.11.1-0.70.6
Pavlov. Cond. latency score0.50.91.3-1.11.1-0.70.7
Pavlov. Cond. lever contacts0.40.70.7-0.80.8-0.80.8
Pavlov. Cond. magazine entry number1.31.72.31.5-1.51.1-1.0
Pavlov. Cond. intertrial magazine entries0.91.92.11.4-1.41.4-1.3
Pavlov. Cond. lever-magazine prob. diff.0.50.71.1-1.11.1-0.60.5
Pavlov. Cond. response bias1.11.51.6-1.31.3-1.21.1
Time in closed arm before self-admin2.54.45.91.8-1.82.3-2.4
Time in closed arm after self-admin6.87.710.22.4-2.43.0-3.2
Time in open arm before self-admin0.20.20.30.6-0.60.3-0.2
Time in open arm after self-admin3.84.24.6-1.91.9-2.12.2
Bone: periosteal estimation1.74.04.72.2-2.21.9-1.8
Bone: periosteal perimeter0.51.01.51.2-1.20.9-0.6
Bone: post-yield work0.00.10.10.3-0.30.00.2
Progressive ratio test 1 active lever presses1.01.71.81.3-1.31.3-1.3
Progressive ratio test 1 breakpoint0.91.51.61.2-1.21.2-1.3
Progressive ratio test 1 inactive lever presses0.10.20.40.4-0.40.5-0.6
Progressive ratio test 2 active lever presses1.11.51.81.2-1.21.2-1.3
Progressive ratio test 2 breakpoint0.91.21.51.0-1.01.1-1.2
Progressive ratio test 2 inactive lever presses0.82.52.71.5-1.51.6-1.7
Incentive Sensitization - Responses0.10.20.2-0.40.4-0.50.4
Incentive Sensitization - Breakpoint0.10.20.3-0.40.4-0.50.4
Sum of active levers in priming session hrs 5-60.00.00.1-0.10.1-0.10.3
Progressive ratio0.30.80.9-0.80.8-1.00.8
Food seeking constrained by brief footshock0.00.10.10.3-0.30.2-0.1
Seeking ratio, punishment vs. effort1.22.73.01.6-1.61.7-1.6
Retroperitoneal fat weight0.00.20.5-0.00.1-0.30.7
Reaction time number correct0.93.33.61.9-1.91.8-1.7
Reaction time mean minus median0.00.30.4-0.60.6-0.60.3
Reaction time mean minus median AUC0.21.11.4-1.21.2-1.00.7
Reaction time num false alarms0.10.10.20.4-0.40.1-0.2
Reaction time num false alarms AUC0.10.20.30.6-0.60.2-0.2
Reaction time trials correct on left0.93.33.61.9-1.91.8-1.7
Reaction time trials on left1.03.23.51.9-1.91.8-1.7
Reaction time mean3.47.48.5-2.92.9-2.72.3
Reaction time mean AUC3.17.48.5-2.92.9-2.72.3
Median of all reaction times6.19.510.7-3.33.3-3.02.7
Reaction time omissions0.40.70.9-0.80.8-1.00.8
Reaction time false alarm rate0.20.30.4-0.40.4-0.60.6
Reaction time premature initiation rate0.71.01.4-1.21.2-1.00.7
Reaction time premature initiations0.00.00.0-0.10.10.0-0.2
Std. dev. reaction times0.62.02.3-1.51.5-1.51.1
Reaction time trials completed1.03.23.51.9-1.91.8-1.7
Reaction time trials AUC0.82.93.11.8-1.81.7-1.6
Run reversals in cocaine runway, females1.92.22.2-1.51.5-1.51.4
Run reversals in cocaine runway, males1.01.11.31.2-1.11.0-0.9
Latency to leave start box in cocaine runway0.30.40.9-0.30.3-0.81.0
Latency to leave start box in cocaine runway, F0.20.30.6-0.30.3-0.60.7
Latency to leave start box in cocaine runway, M0.30.30.50.7-0.70.3-0.3
Std. dev. time between licks in bursts0.00.00.00.0-0.00.1-0.2
Total sessions with >9 infusions0.50.70.8-0.70.7-0.90.9
Short access day 1 total inactive lever presses0.00.10.10.3-0.30.2-0.2
Short access day 10 total inactive lever presses0.00.10.1-0.20.2-0.20.3
Short access day 1 total infusions0.61.11.3-0.91.0-1.11.2
Short access day 10 total infusions0.71.21.3-1.11.1-1.11.1
Short access total infusions1.21.72.0-1.21.2-1.41.4
Short access day 1 locomotion0.40.60.9-1.01.0-0.70.5
Short access day 10 total locomotion0.00.10.1-0.30.3-0.20.0
Short access total locomotion0.60.91.1-1.01.0-0.90.8
One hour access (0.3 mA shock)0.70.81.30.8-0.80.9-1.1
Compulsive drug intake0.40.50.7-0.70.7-0.80.7
One hour access (shock baseline)0.51.31.51.1-1.11.1-1.2
Social response proportion3.13.94.61.8-1.92.1-2.1
Social responses1.11.51.61.2-1.21.2-1.3
Social time1.01.61.9-1.31.3-1.41.1
Soleus weight1.13.24.72.2-2.11.5-1.2
Bone: stiffness0.10.20.30.6-0.60.4-0.3
Tibialis anterior weight4.615.818.34.3-4.33.8-3.4
Time to tail flick, vehicle, before self-admin0.10.10.30.1-0.0-0.50.5
Time to tail flick, vehicle, after self-admin0.10.10.2-0.50.50.1-0.0
Time to tail flick, test, before self-admin2.02.32.71.4-1.41.6-1.6
Time to tail flick, test, after self-admin1.11.21.9-1.41.4-0.70.7
Delta time to tail flick, vehicle, before/after SA0.70.71.3-1.21.2-0.30.4
Delta time to tail flick, test, before/after SA2.22.73.4-1.81.8-1.51.4
Tibia length5.114.215.74.0-4.03.7-3.5
Ambulatory time before self-admin0.30.81.0-0.90.9-0.91.0
Ambulatory time after self-admin0.00.00.1-0.30.30.00.0
Bone: tissue strength0.30.30.30.5-0.50.6-0.5
Total heroin consumption3.33.94.5-2.12.1-1.91.8
Bone: trabecular number3.66.88.52.9-2.92.5-2.1
Bone: trabecular spacing3.75.47.0-2.62.6-2.01.8
Bone: trabecular thickness3.54.87.32.7-2.71.8-1.3
Bone: trabecular tissue density0.71.31.5-1.21.2-1.11.0
Water consumed over 24 hours2.34.45.02.0-2.02.2-2.2
Number of responses in last shaping day0.00.00.0-0.20.2-0.20.2