Hub : Genes

LOC102549281

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC intron excision ratio chr14_83198846_83204034 0.09 0.05 1.4e-03 0.02 0.04 0.02 0.01 6.5e-02 7.1e-03 6.2e-02 8.3e-02
2 Liver intron excision ratio chr14_83198846_83203753 0.03 0.02 2.6e-04 0.03 0.02 0.03 0.03 1.6e-04 1.1e-03 3.3e-04 4.0e-04
3 Liver intron excision ratio chr14_83203922_83204034 0.03 0.02 2.8e-04 0.03 0.02 0.02 0.03 6.4e-04 1.2e-03 1.1e-03 8.2e-04
4 BLA isoform ratio XR_010057731.1 0.07 0.04 1.3e-03 0.07 0.03 0.05 0.04 1.9e-04 1.5e-02 7.9e-04 3.2e-03
5 PL gene expression LOC102549281 0.14 0.07 4.8e-11 0.11 0.1 0.1 0.11 3.5e-12 7.3e-11 6.1e-11 5.0e-12
6 OFC gene expression LOC102549281 0.38 0.16 1.3e-03 0.03 0.06 0.07 0.04 7.1e-02 1.3e-02 7.7e-03 3.2e-02
7 pVTA intron excision ratio chr14_83198846_83204034 0.04 0.02 3.1e-03 0.05 0.03 0.04 0.04 8.3e-05 3.5e-03 3.6e-04 1.8e-04
8 IC gene expression LOC102549281 0.1 0.05 5.7e-04 0.06 0.09 0.07 0.07 1.9e-03 1.8e-04 4.9e-04 7.7e-04
9 Brain gene expression LOC102549281 0.11 0.05 5.8e-12 0.11 0.13 0.12 0.12 2.1e-10 3.3e-12 2.3e-11 1.5e-11
10 Liver gene expression LOC102549281 0.04 0.02 3.6e-04 0.03 0.02 0.01 0.02 2.1e-04 5.4e-03 1.6e-02 2.4e-03
11 Brain intron excision ratio chr14_83198846_83204034 0.04 0.03 3.6e-03 0.03 0.03 0.01 0.02 2.1e-03 1.7e-03 1.3e-02 2.3e-03
12 PL intron excision ratio chr14_83198846_83204034 0.05 0.03 5.0e-05 0.02 0.03 0.02 0.02 1.7e-03 2.7e-04 3.3e-03 1.5e-03
13 BLA gene expression LOC102549281 0.13 0.07 1.9e-06 0.09 0.12 0.1 0.1 1.1e-05 1.1e-06 5.3e-06 7.4e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.61.01.7-0.7-1.31.3-0.90.9-0.1-0.81.21.31.1-1.3-0.90.5
Area under the delay curve9.411.014.43.23.2-3.23.8-3.6-2.63.4-3.5-3.3-3.63.53.1-3.1
BMI with tail0.82.86.51.41.5-1.51.6-1.6-0.61.8-2.1-1.9-2.02.61.2-0.9
BMI without tail0.20.72.20.90.9-0.90.7-0.7-0.60.8-1.1-0.9-0.71.50.30.0
Body weight2.711.716.24.03.0-3.03.5-3.5-3.23.6-3.8-3.5-3.54.02.6-2.8
Weight adjusted by age1.31.93.11.70.8-0.81.6-1.4-1.41.5-1.6-1.4-1.71.71.0-0.9
Bone surface0.10.10.40.30.1-0.10.4-0.4-0.60.6-0.3-0.2-0.20.30.3-0.3
Bone volume0.00.10.30.0-0.30.3-0.10.1-0.50.10.20.30.3-0.3-0.1-0.1
Breakpoint value in progressive ratio session0.20.20.50.50.6-0.60.1-0.1-0.60.2-0.3-0.3-0.60.30.4-0.7
Number of licking bursts0.60.92.81.31.5-1.50.5-0.5-1.70.5-0.4-0.4-0.20.30.5-1.1
Context. condit. distance diff. score2.42.95.4-1.8-2.32.3-1.61.61.6-1.51.51.51.2-1.2-1.61.7
Locomotion velocity, session 10.30.32.4-0.9-0.20.2-0.10.11.6-0.00.0-0.3-0.1-0.20.40.2
Locomotion distance, session 11.21.53.9-1.2-2.02.0-0.80.80.9-0.81.11.10.6-1.0-1.21.3
Locomotion velocity, session 20.60.72.1-1.3-0.30.3-0.80.81.4-0.80.80.40.6-1.40.4-0.0
Locomotion distance, session 22.02.86.3-2.5-1.71.7-1.61.62.3-1.51.41.31.4-1.3-1.11.8
Locomotion velocity, session 30.60.71.8-1.0-1.31.3-0.50.50.9-0.50.70.80.4-0.5-0.91.1
Locomotion distance, session 30.70.81.30.30.7-0.71.0-1.00.41.1-1.0-1.1-0.81.11.0-0.4
Stereotopy head waving bouts, day 31.51.72.1-1.3-1.41.4-1.21.21.0-1.21.41.31.4-1.4-1.31.3
Stereotopy head waving duration, day 32.73.34.6-1.9-2.22.2-1.71.71.7-1.61.71.61.9-1.5-1.81.9
Locomotion velocity, session 70.10.10.20.00.0-0.00.3-0.30.50.2-0.3-0.4-0.50.20.5-0.1
Locomotion distance, session 70.40.51.7-1.0-1.01.0-0.40.41.3-0.50.40.40.4-0.3-0.30.6
Stereotopy head waving bouts, day 70.30.40.90.50.6-0.60.7-0.7-0.40.6-0.8-0.7-0.41.00.5-0.3
Stereotopy head waving duration, day 70.20.30.80.60.5-0.50.6-0.6-0.50.6-0.7-0.5-0.20.90.2-0.1
Locomotion velocity, session 82.22.64.8-2.2-1.21.2-1.81.82.2-1.71.71.41.5-1.8-1.01.3
Locomotion distance, session 87.911.415.3-3.8-3.93.9-3.43.43.2-3.33.23.23.0-2.9-3.23.5
Degree of sensitization distance5.35.56.6-2.3-2.62.6-2.52.51.7-2.62.52.42.3-2.4-2.21.9
Degree of sensitization stereotypy0.60.61.20.90.9-0.90.8-0.8-0.90.7-0.9-0.7-0.51.10.5-0.6
Conditioned locomotion0.30.41.2-0.5-1.11.1-0.30.30.1-0.20.40.70.20.0-0.90.7
Cocaine response after cond. corrected1.01.31.81.20.9-0.91.2-1.2-1.31.3-1.0-1.0-1.00.91.1-1.3
Cocaine response after cond. not corrected2.42.85.52.11.2-1.21.8-1.8-2.31.8-1.4-1.3-1.71.21.4-1.9
Cocaine response before conditioning0.20.20.60.8-0.10.10.5-0.5-0.80.3-0.2-0.2-0.80.20.1-0.3
Saline control response0.60.82.8-1.2-1.31.3-0.60.61.7-0.50.40.30.2-0.4-0.41.1
Bone: connectivity density0.30.41.2-0.5-1.11.1-0.40.4-0.0-0.40.70.80.5-0.6-0.70.5
Bone: cortical apparent density0.10.10.20.20.5-0.50.1-0.1-0.2-0.1-0.3-0.1-0.30.5-0.0-0.1
Bone: cortical area2.43.76.92.61.5-1.51.9-1.9-2.51.9-2.0-1.8-2.12.11.2-1.5
Bone: cortical porosity0.40.50.70.80.8-0.80.8-0.8-0.90.6-0.4-0.4-0.60.30.5-0.7
Bone: cortical porosity0.10.10.40.40.5-0.50.4-0.4-0.60.2-0.1-0.1-0.20.10.0-0.2
Bone: cortical thickness1.83.06.52.41.3-1.31.7-1.7-2.61.7-1.8-1.5-1.92.00.8-1.2
Bone: cortical thickness0.30.41.1-0.2-1.01.0-0.30.3-0.4-0.40.30.7-0.10.2-1.10.9
Bone: cortical tissue density0.10.10.30.20.6-0.60.1-0.1-0.30.0-0.4-0.2-0.40.50.1-0.2
Condit. Reinf. active minus inactive responses0.30.30.8-0.20.0-0.00.6-0.60.90.7-0.7-0.8-0.40.70.8-0.2
Condit. Reinf. active-inactive response ratio0.50.64.9-1.2-0.10.1-0.20.22.2-0.0-0.2-0.50.40.20.60.4
Condit. Reinf. active responses0.10.10.5-0.3-0.30.30.2-0.20.70.4-0.3-0.40.10.30.20.2
Condit. Reinf. inactive responses0.20.21.60.8-0.10.10.1-0.1-1.20.10.10.20.1-0.0-0.4-0.1
Incentive salience index mean0.81.01.80.60.6-0.61.2-1.20.21.2-1.2-1.3-0.91.21.2-0.7
Condit. Reinf. lever presses0.71.01.91.10.6-0.61.2-1.2-0.51.1-1.3-1.2-1.01.40.8-0.7
Condit. Reinf. active minus inactive responses0.91.12.3-0.9-1.51.5-1.00.90.9-0.90.90.80.7-0.9-1.01.2
Condit. Reinf. active-inactive response ratio0.10.10.3-0.1-0.50.50.3-0.30.40.3-0.3-0.3-0.20.40.20.1
Condit. Reinf. active responses1.82.44.4-1.7-2.12.1-1.41.41.9-1.31.41.20.9-1.3-1.31.8
Condit. Reinf. inactive responses2.22.83.6-1.9-1.71.7-1.71.71.9-1.61.61.51.3-1.6-1.51.8
Condit. Reinf. lever presses0.40.51.3-0.7-1.11.1-0.60.50.9-0.50.40.50.2-0.3-0.81.1
Condit. Reinf. lever reinforcers received1.31.73.9-1.4-2.02.0-1.11.01.7-1.01.00.90.5-0.9-1.11.6
Conditioned reinforcement - actives1.52.62.91.61.7-1.71.7-1.7-1.41.6-1.6-1.5-1.61.51.5-1.7
Conditioned reinforcement - inactives3.45.05.92.12.3-2.32.4-2.4-1.22.3-2.4-2.4-2.42.22.3-2.0
Conditioned locomotion1.72.22.91.71.7-1.71.5-1.6-1.71.6-1.2-1.2-1.21.01.2-1.6
Patch foraging indifference point 0 sec0.00.10.30.30.3-0.3-0.10.1-0.6-0.1-0.1-0.1-0.30.10.1-0.2
Patch foraging indifference point AUC0.20.32.4-0.9-0.30.3-0.30.31.6-0.20.2-0.00.3-0.40.20.6
Delay disc. indifference point, 0s delay7.58.312.02.72.5-2.53.3-3.2-2.53.2-3.1-2.6-3.13.52.3-2.5
Delay disc. indifference point, 16s delay5.45.97.22.22.6-2.62.7-2.5-1.72.3-2.4-2.4-2.62.22.6-2.7
Delay disc. indifference point, 2s delay7.17.910.23.02.4-2.43.2-3.1-2.63.2-2.9-2.6-3.13.12.3-2.4
Delay disc. indifference point, 24s delay5.05.67.72.12.1-2.12.6-2.6-1.62.4-2.5-2.3-2.82.62.3-2.5
Delay disc. indifference point, 4s delay5.86.19.12.52.2-2.23.0-2.8-2.12.6-2.5-2.4-2.82.52.2-2.1
Delay disc. indifference point, 8s delay2.22.53.81.31.7-1.71.9-1.8-0.81.6-1.7-1.7-1.71.71.5-1.1
Indifference point function ln k0.20.31.50.5-0.60.6-0.00.0-1.2-0.10.50.6-0.0-0.6-0.5-0.2
Indifference point function log k0.20.31.50.5-0.60.6-0.00.0-1.2-0.10.50.6-0.0-0.6-0.5-0.2
Patch foraging total patch changes 0 sec0.10.10.20.40.5-0.50.0-0.0-0.50.0-0.3-0.3-0.40.20.3-0.2
Patch foraging total patch changes 12 sec0.00.00.10.40.3-0.30.0-0.0-0.40.1-0.2-0.1-0.10.2-0.0-0.2
Patch foraging total patch changes 18 sec0.30.51.10.21.0-1.00.4-0.40.50.5-0.8-1.0-0.40.71.0-0.5
Patch foraging total patch changes 24 sec1.72.95.6-2.2-1.71.7-1.81.82.4-1.71.21.21.4-0.8-1.52.2
Patch foraging total patch changes 6 sec0.10.10.20.30.3-0.30.1-0.10.10.2-0.2-0.4-0.50.00.5-0.3
Patch foraging time to switch 0 sec0.20.31.2-0.20.1-0.1-0.60.6-0.3-0.60.30.71.10.2-1.00.5
Patch foraging water rate 0 sec0.40.82.01.10.7-0.70.8-0.8-0.30.9-0.8-1.2-1.40.31.1-0.7
Patch foraging water rate 12 sec0.00.10.20.2-0.40.40.2-0.20.30.2-0.0-0.3-0.5-0.1-0.00.4
Patch foraging water rate 18 sec1.11.73.3-0.2-1.71.7-1.11.1-0.5-1.21.41.50.8-1.4-1.81.4
Patch foraging water rate 24 sec0.20.30.6-0.0-0.50.5-0.60.60.6-0.80.50.10.1-0.7-0.50.7
Patch foraging water rate 6 sec0.10.10.30.5-0.50.5-0.10.1-0.2-0.20.20.0-0.4-0.4-0.40.5
Seeking ratio, delayed vs. immediate footshock0.20.21.1-0.40.1-0.1-0.60.60.6-0.30.60.30.0-1.10.3-0.1
Distance traveled before self-admin0.00.10.2-0.40.0-0.0-0.30.30.2-0.10.20.30.3-0.30.10.1
Distance traveled after self-admin0.10.10.20.10.4-0.40.2-0.2-0.40.3-0.3-0.0-0.40.30.3-0.1
Extensor digitorum longus weight2.59.916.44.02.7-2.73.3-3.3-3.53.4-3.0-3.0-3.22.82.6-3.0
Bone: elastic displacement0.40.51.0-0.1-0.60.6-0.70.7-0.3-0.70.80.91.0-0.7-1.00.7
Bone: elastic work0.30.31.80.9-0.30.3-0.20.2-1.4-0.20.40.50.5-0.3-0.80.2
Bone: endosteal estimation0.00.10.20.0-0.20.2-0.40.4-0.1-0.30.30.20.3-0.5-0.20.1
Bone: endosteal perimeter0.30.71.21.10.6-0.60.8-0.8-1.00.9-0.9-1.0-0.90.70.9-0.8
Epididymis fat weight0.82.85.82.21.6-1.61.6-1.6-2.41.6-1.7-1.4-1.31.91.0-1.7
Delta time in closed arm before/after self-admin3.73.55.9-1.7-2.42.4-2.12.11.0-1.71.82.01.3-1.5-2.01.6
Delta time in open arm before/after self-admin5.75.79.32.03.1-3.12.5-2.5-1.22.1-2.5-2.5-2.22.32.4-2.0
Diff in mean of infusions in LGA sessions0.10.10.3-0.60.4-0.4-0.10.10.6-0.0-0.2-0.0-0.10.40.20.2
Delay discount exponential model param9.410.514.1-3.1-3.13.1-3.83.52.5-3.33.43.23.6-3.4-3.02.9
Extinction: sum of active levers before priming1.41.52.30.81.1-1.11.2-1.2-0.41.2-1.3-1.3-1.51.31.5-1.5
Active lever presses in extinction session 61.01.01.60.91.1-1.11.0-1.0-1.31.1-0.8-0.6-1.10.90.8-1.2
Bone: final force0.10.10.40.60.3-0.30.00.0-0.50.1-0.5-0.3-0.20.6-0.10.1
Bone: final moment0.10.20.70.70.4-0.40.0-0.0-0.90.1-0.4-0.2-0.20.4-0.1-0.0
Food consumed during 24 hour testing period0.10.10.8-0.10.4-0.4-0.20.20.9-0.3-0.1-0.4-0.0-0.30.6-0.2
Glucose11.618.334.32.85.2-5.24.0-3.9-0.14.0-4.5-5.3-3.73.55.9-4.6
Heart weight0.50.81.20.90.6-0.60.9-0.9-0.50.8-0.9-1.1-1.00.81.0-1.1
Delay discount hyperbolic model param9.710.814.4-3.2-3.13.1-3.83.62.5-3.43.53.33.6-3.5-3.02.9
Intermittent access intake day 1-15 change0.61.32.00.71.3-1.31.0-1.0-0.21.2-1.1-1.3-1.11.01.4-1.3
Intermittent access intake escalation0.81.72.51.11.3-1.31.4-1.3-0.61.4-1.3-1.4-1.41.11.6-1.6
Intermittent access intake escalation 20.30.30.80.50.9-0.90.4-0.3-0.50.4-0.4-0.5-0.40.20.6-0.7
Intermitt. access day 1 inactive lever presses0.20.61.10.8-0.20.21.0-1.0-0.41.0-0.7-0.8-1.00.70.7-0.7
Intermitt. access day 15 inactive lever presses1.12.24.31.11.2-1.21.6-1.60.31.5-1.8-2.1-1.81.61.8-1.0
Intermitt. access escalation Index0.50.72.2-1.0-1.01.0-0.80.81.5-0.40.40.30.7-0.2-0.50.8
Intermittent access day 1 total infusions1.62.53.71.51.9-1.91.5-1.5-1.51.6-1.6-1.3-1.51.71.4-1.5
Intermittent access day 15 total infusions3.55.16.62.12.6-2.62.2-2.2-1.72.4-2.2-2.2-2.22.12.3-2.4
Intermittent access terminal intake (last 3 days)2.33.14.61.72.1-2.11.7-1.7-1.51.9-1.6-1.6-1.61.41.8-1.8
Intermittent access total infusions3.13.75.01.92.2-2.21.9-1.9-1.72.1-1.7-1.7-1.81.51.9-2.1
Intermittent access day 1 locomotion0.00.10.1-0.40.1-0.1-0.30.30.2-0.00.20.30.3-0.3-0.00.2
Intermittent access day 15 total locomotion2.64.86.12.32.5-2.52.2-2.2-1.92.3-2.2-2.1-2.12.21.9-2.1
Intermittent access total locomotion2.22.73.61.61.8-1.81.7-1.7-1.21.9-1.5-1.6-1.61.31.8-1.7
Intermittent access standard deviation0.00.10.10.30.3-0.30.4-0.3-0.20.4-0.4-0.3-0.30.30.2-0.0
Left kidney weight0.20.74.51.6-0.60.60.3-0.3-2.10.3-0.00.2-0.10.3-0.90.0
Right kidney weight0.21.17.51.7-0.60.60.5-0.5-2.70.6-0.10.4-0.40.5-1.10.0
Cocaine induced anxiety1.52.23.11.41.5-1.51.6-1.6-0.71.4-1.5-1.7-1.61.21.8-1.5
Post-drug Anxiety2.62.83.71.51.9-1.91.4-1.4-1.01.5-1.8-1.8-1.91.81.8-1.8
Baseline Anxiety0.10.20.60.00.6-0.6-0.10.1-0.30.2-0.4-0.2-0.30.80.1-0.4
Tail length0.72.87.42.61.6-1.61.6-1.6-2.71.5-1.3-1.3-1.21.01.2-1.6
Length with tail1.14.812.63.41.8-1.82.1-2.1-3.62.0-1.8-1.7-1.81.61.4-2.1
Length without tail0.92.86.42.41.2-1.21.7-1.7-2.51.6-1.4-1.3-1.61.41.1-1.9
Times rat made contact with spout0.50.63.9-1.10.4-0.4-0.60.62.0-0.60.2-0.20.2-0.60.60.1
Lifetime Intake2.63.14.21.82.0-2.01.8-1.8-1.71.8-1.5-1.6-1.71.31.8-2.0
Liver weight, left0.40.62.1-0.1-1.41.4-0.50.5-0.4-0.40.70.90.4-0.5-1.10.7
Liver weight, right0.81.32.7-0.6-1.61.6-1.11.10.2-1.00.91.10.8-0.6-1.61.5
Locomotor activity0.30.51.60.31.3-1.30.5-0.50.10.3-0.4-0.8-0.3-0.01.1-0.6
Locomotor testing distance0.61.12.41.31.0-1.01.1-1.1-1.51.0-0.8-0.8-1.10.70.7-0.8
Locomotor testing rearing1.32.63.21.81.7-1.71.6-1.6-1.41.7-1.5-1.7-1.41.21.7-1.7
Locomotion in novel chamber0.40.50.9-0.4-1.01.0-0.90.80.2-0.50.60.80.5-0.4-0.80.7
Locomotion in novel chamber post-restriction1.11.75.1-2.0-1.31.3-1.31.32.2-1.10.90.91.1-0.8-0.81.3
Fecal boli incidents, locomotor time 10.20.40.7-0.7-0.60.6-0.50.60.8-0.70.70.50.5-0.9-0.20.3
Change in fecal boli incidents, locomotor task0.40.42.2-1.0-0.10.1-0.30.41.5-0.60.40.20.8-0.5-0.00.5
Time >=10cm from walls, locomotor time 10.10.10.3-0.40.1-0.1-0.40.4-0.2-0.4-0.00.30.40.4-0.50.2
Bouts of movement, locomotor time 10.30.30.60.00.3-0.30.7-0.70.40.6-0.6-0.6-0.40.80.6-0.4
Total resting periods, locomotor time 10.50.51.10.10.4-0.40.9-0.90.60.9-0.9-0.9-0.61.00.8-0.5
Rest time, locomotor task time 10.10.10.8-0.4-0.30.3-0.10.20.90.0-0.1-0.20.10.00.20.3
Distance moved, locomotor task time 10.10.20.60.10.4-0.4-0.30.3-0.8-0.50.30.40.4-0.4-0.40.0
Vertical activity count, locomotor time 10.20.40.7-0.60.5-0.5-0.80.70.0-0.80.70.70.8-0.8-0.20.1
Time >=10cm from walls, locomotor time 20.10.20.4-0.7-0.00.0-0.60.60.3-0.60.40.50.4-0.4-0.40.3
Bouts of movement, locomotor time 20.20.30.90.4-0.40.40.5-0.6-0.20.7-0.5-0.5-1.00.80.1-0.1
Total resting periods, locomotor time 20.20.41.20.4-0.40.40.6-0.70.00.8-0.7-0.7-1.11.00.3-0.1
Rest time, locomotor task time 20.40.51.3-0.9-0.90.9-0.70.71.1-0.60.50.40.6-0.5-0.50.8
Distance moved, locomotor task time 20.10.10.2-0.10.2-0.2-0.20.2-0.4-0.40.30.40.5-0.3-0.40.0
Vertical activity count, locomotor time 20.10.10.40.10.6-0.60.1-0.1-0.60.20.00.1-0.1-0.10.2-0.5
Light reinforcement 10.20.51.41.2-0.10.10.8-0.8-1.20.9-0.7-0.6-0.70.80.2-0.3
Light reinforcement 20.10.20.50.3-0.30.3-0.30.3-0.6-0.20.20.40.2-0.1-0.70.6
Bone: marrow area0.00.10.2-0.0-0.30.3-0.40.4-0.1-0.30.30.20.3-0.4-0.20.2
Bone: maximum diameter2.95.37.52.72.3-2.32.2-2.2-2.02.2-2.4-2.6-2.52.22.2-2.2
Bone: maximum force0.00.10.40.50.0-0.0-0.20.2-0.6-0.1-0.10.00.10.2-0.40.3
Bone: maximum moment0.10.10.90.70.1-0.1-0.20.2-1.0-0.20.00.20.1-0.0-0.40.1
Mean time between licks in bursts0.20.52.0-0.9-0.10.1-0.70.71.4-0.50.60.20.8-1.00.20.1
Mean num. licks in bursts0.91.58.0-2.0-1.21.2-0.90.92.8-0.90.60.30.4-0.7-0.11.1
Cd content in liver0.30.30.70.30.9-0.90.4-0.40.00.5-0.6-0.7-0.20.40.8-0.6
Co content in liver0.80.91.71.10.7-0.71.1-1.1-0.71.0-0.9-0.9-1.30.90.8-0.8
Cu content in liver0.10.20.40.2-0.20.20.5-0.5-0.20.5-0.4-0.3-0.50.40.5-0.6
Fe content in liver0.70.82.8-1.5-1.31.3-0.50.51.7-0.60.60.60.5-0.4-0.40.8
K content in liver4.24.06.72.31.3-1.32.3-2.3-2.62.3-1.8-1.5-2.21.91.5-2.2
Mg content in liver4.24.25.92.41.7-1.72.3-2.3-2.42.2-1.9-1.8-2.22.01.6-2.1
Mn content in liver0.10.10.40.40.3-0.30.4-0.4-0.60.5-0.1-0.1-0.2-0.00.3-0.4
Na content in liver5.76.28.02.12.1-2.12.7-2.7-1.22.7-2.7-2.7-2.82.62.8-2.6
Rb content in liver0.70.81.00.90.8-0.80.9-0.9-0.90.9-0.9-0.8-0.91.00.8-0.8
Se content in liver2.83.36.52.31.5-1.52.0-1.9-2.51.9-1.4-1.4-1.81.31.5-2.2
Sr content in liver2.32.03.61.41.9-1.91.2-1.2-0.71.2-1.4-1.6-1.21.21.5-1.3
Zn content in liver0.10.10.70.70.1-0.10.1-0.1-0.80.10.10.00.0-0.2-0.1-0.3
Bone: minimum diameter0.10.20.40.1-0.50.5-0.40.4-0.3-0.40.40.40.3-0.5-0.60.4
Time in familiar zone, hab. session 11.61.62.7-1.5-0.70.7-1.41.41.2-1.41.11.21.7-1.0-1.11.4
Time in novel zone, hab. session 10.90.92.01.40.7-0.71.0-1.0-1.40.9-0.6-0.7-1.20.40.7-1.1
Total zone transitions, hab. session 10.50.72.4-1.3-0.60.6-0.70.81.6-0.70.60.50.7-0.6-0.41.1
Total locomotion distance, hab. session 10.00.10.3-0.4-0.10.10.1-0.10.60.2-0.0-0.10.0-0.10.40.1
Locomotion velocity, hab. session 10.10.10.7-0.5-0.30.30.1-0.10.80.2-0.1-0.20.10.00.30.2
Time in familiar zone, hab. session 23.33.54.4-2.1-1.61.6-2.02.01.5-2.01.92.02.0-1.6-2.01.8
Time in novel zone, hab. session 22.12.23.41.91.5-1.51.4-1.4-1.31.4-1.5-1.6-1.71.21.4-1.3
Total zone transitions, hab. session 20.10.10.4-0.10.1-0.10.3-0.30.50.6-0.5-0.6-0.20.40.50.1
Total locomotion distance, hab. session 20.30.40.90.30.7-0.70.5-0.50.20.7-0.7-0.9-0.30.50.9-0.3
Locomotion velocity, hab. session 20.60.71.40.60.9-0.90.9-0.9-0.11.0-1.0-1.2-0.60.81.1-0.7
Novel to familiar place preference ratio2.32.63.80.91.5-1.51.7-1.70.11.8-1.8-1.9-1.81.72.0-1.3
Novelty place preference2.22.43.51.01.4-1.41.6-1.6-0.11.7-1.7-1.8-1.81.61.9-1.3
Time in novel zone, NPP test1.81.92.90.91.3-1.31.5-1.50.01.6-1.6-1.7-1.71.41.7-1.2
Total zone transitions, NPP test0.10.20.9-0.2-1.01.00.0-0.0-0.10.10.20.4-0.2-0.0-0.50.5
Total locomotion distance, NPP test0.10.10.20.1-0.20.20.4-0.4-0.20.5-0.2-0.2-0.50.30.1-0.1
Locomotion velocity, NPP test0.20.30.70.30.1-0.10.8-0.8-0.40.8-0.5-0.4-0.70.60.4-0.4
Intraocular pressure0.30.42.6-0.60.7-0.7-0.10.11.6-0.1-0.5-0.60.30.50.40.5
Delta distance traveled before/after self-admin0.30.40.70.50.5-0.50.8-0.8-0.50.7-0.6-0.4-0.60.80.2-0.4
Delta ambulatory time before/after self-admin0.00.00.20.00.1-0.10.4-0.4-0.30.2-0.00.1-0.10.2-0.1-0.1
Parametrial fat weight1.94.48.50.22.4-2.41.6-1.61.61.9-2.6-2.9-1.62.42.9-1.3
Pavlov. Cond. lever latency0.10.10.50.30.3-0.30.2-0.2-0.30.4-0.1-0.3-0.2-0.10.6-0.7
Pavlov. Cond. magazine entry latency1.31.62.5-1.6-1.01.0-1.21.21.6-1.41.21.11.3-1.2-1.11.6
Pavlov. Cond. change in total contacts0.90.91.70.41.3-1.31.0-1.00.10.9-1.1-1.1-0.81.11.1-0.6
Pavlov. Cond. index score0.81.01.9-1.2-1.01.0-0.90.81.2-1.10.90.90.9-0.6-1.11.4
Pavlov. Cond. latency score0.81.02.0-1.2-0.90.9-0.90.91.1-1.10.91.01.0-0.6-1.21.4
Pavlov. Cond. lever contacts0.30.41.0-0.7-0.60.6-0.50.50.7-0.70.40.50.5-0.2-0.81.0
Pavlov. Cond. magazine entry number0.91.13.31.50.9-0.90.8-0.8-1.81.0-0.8-0.7-0.90.80.7-1.3
Pavlov. Cond. intertrial magazine entries0.50.73.11.3-0.20.20.8-0.8-1.80.8-0.3-0.2-0.90.40.0-0.7
Pavlov. Cond. lever-magazine prob. diff.0.91.22.0-1.2-1.11.1-0.90.91.1-1.11.01.01.0-0.7-1.21.4
Pavlov. Cond. response bias0.10.10.4-0.5-0.40.4-0.10.10.6-0.30.30.30.3-0.2-0.40.6
Pavlov. Cond. lever latency1.92.57.02.21.5-1.51.6-1.6-2.61.6-1.2-1.0-0.91.21.1-1.8
Pavlov. Cond. magazine entry latency0.00.00.10.00.1-0.1-0.0-0.00.2-0.0-0.3-0.2-0.40.30.00.3
Pavlov. Cond. change in total contacts0.61.02.7-1.3-1.01.0-1.01.01.6-1.00.60.60.3-0.5-0.71.3
Pavlov. Cond. index score0.81.02.7-1.3-1.01.0-1.01.01.7-1.00.70.60.4-0.6-0.81.3
Pavlov. Cond. latency score0.91.22.6-1.4-1.21.2-1.11.11.6-1.10.80.80.4-0.7-0.91.4
Pavlov. Cond. lever contacts1.92.66.6-2.2-1.71.7-1.61.62.6-1.61.31.10.9-1.2-1.11.8
Pavlov. Cond. magazine entry number0.10.10.30.30.0-0.00.5-0.5-0.50.4-0.1-0.1-0.10.10.2-0.4
Pavlov. Cond. intertrial magazine entries0.00.10.20.1-0.40.40.2-0.2-0.20.10.20.10.1-0.30.0-0.3
Pavlov. Cond. lever-magazine prob. diff.0.91.22.7-1.4-1.11.1-1.11.11.6-1.10.80.80.6-0.7-0.91.4
Pavlov. Cond. response bias0.91.33.5-1.6-1.01.0-1.21.21.9-1.20.80.70.6-0.8-0.81.2
Time in closed arm before self-admin0.60.81.6-0.2-0.80.8-0.70.7-0.4-0.91.01.01.1-0.9-1.30.9
Time in closed arm after self-admin3.13.35.3-1.1-2.22.2-1.91.90.1-1.72.02.11.7-1.7-2.31.6
Time in open arm before self-admin0.00.00.10.1-0.30.3-0.10.10.00.10.10.0-0.0-0.10.0-0.1
Time in open arm after self-admin1.71.92.90.81.7-1.71.4-1.40.11.1-1.6-1.7-1.41.51.7-1.1
Bone: periosteal estimation0.30.72.01.40.5-0.50.6-0.6-1.40.7-0.8-0.8-0.90.80.4-0.6
Bone: periosteal perimeter1.83.25.02.21.3-1.31.8-1.8-2.01.9-1.9-1.9-2.02.01.4-1.5
Bone: post-yield work0.10.20.5-0.30.4-0.4-0.50.5-0.0-0.50.50.40.3-0.7-0.0-0.1
Progressive ratio test 1 active lever presses2.42.94.01.51.6-1.61.8-1.8-1.31.9-1.6-1.6-1.91.42.0-2.0
Progressive ratio test 1 breakpoint2.53.04.11.61.6-1.61.9-1.9-1.42.0-1.7-1.6-1.91.52.0-2.0
Progressive ratio test 1 inactive lever presses3.55.16.82.02.3-2.32.2-2.2-1.32.4-2.4-2.4-2.52.12.6-2.3
Progressive ratio test 2 active lever presses2.32.74.71.42.2-2.21.7-1.6-1.11.5-1.6-1.6-1.41.51.7-1.7
Progressive ratio test 2 breakpoint2.12.44.21.32.0-2.01.6-1.6-1.01.4-1.5-1.5-1.31.41.6-1.6
Progressive ratio test 2 inactive lever presses3.55.77.22.12.7-2.72.5-2.5-1.12.4-2.6-2.6-2.22.62.4-2.0
Incentive Sensitization - Responses0.81.23.50.81.9-1.90.9-0.9-0.50.7-1.1-1.1-0.51.20.9-0.8
Incentive Sensitization - Breakpoint0.81.03.20.71.8-1.80.8-0.8-0.40.6-1.0-1.0-0.41.10.8-0.7
Sum of active levers in priming session hrs 5-60.90.81.50.90.9-0.90.7-0.7-1.11.0-0.8-0.6-1.21.00.7-1.1
Progressive ratio0.10.10.80.20.9-0.90.2-0.1-0.5-0.1-0.10.00.00.00.1-0.1
Food seeking constrained by brief footshock2.63.25.52.12.0-2.01.8-1.8-2.41.7-1.6-1.4-1.71.61.4-1.6
Seeking ratio, punishment vs. effort0.40.61.11.1-0.30.31.0-1.0-0.81.0-0.7-0.8-1.10.70.5-0.5
Retroperitoneal fat weight0.52.35.30.21.4-1.41.2-1.21.11.6-2.1-2.2-1.12.31.7-0.5
Reaction time number correct0.40.71.7-0.8-0.40.4-1.11.10.8-1.00.90.61.0-1.3-0.50.8
Reaction time mean minus median0.10.10.50.00.6-0.6-0.00.0-0.1-0.1-0.1-0.3-0.1-0.00.5-0.7
Reaction time mean minus median AUC0.20.50.60.70.8-0.80.6-0.6-0.80.6-0.7-0.7-0.80.70.6-0.8
Reaction time num false alarms0.81.22.41.10.8-0.81.2-1.2-1.11.2-1.2-0.9-1.31.60.6-0.7
Reaction time num false alarms AUC0.50.81.81.00.6-0.60.9-0.9-1.20.9-1.0-0.6-1.11.40.2-0.4
Reaction time trials correct on left0.40.71.7-0.8-0.40.4-1.11.10.8-1.00.90.61.0-1.3-0.50.8
Reaction time trials on left0.40.81.8-0.8-0.40.4-1.11.10.9-1.01.00.61.0-1.3-0.50.8
Reaction time mean0.00.00.2-0.00.2-0.2-0.10.2-0.3-0.30.10.20.1-0.10.1-0.5
Reaction time mean AUC0.00.00.1-0.0-0.00.0-0.20.2-0.3-0.40.20.30.2-0.1-0.1-0.3
Median of all reaction times0.00.10.2-0.2-0.10.1-0.20.2-0.2-0.40.30.40.3-0.2-0.2-0.3
Reaction time omissions0.10.10.4-0.5-0.50.5-0.10.10.7-0.00.20.20.4-0.1-0.20.5
Reaction time false alarm rate1.21.73.61.40.8-0.81.4-1.5-1.81.4-1.4-0.8-1.51.90.4-0.8
Reaction time premature initiation rate3.24.57.3-2.0-2.72.7-1.91.91.6-2.01.92.01.8-1.5-2.42.5
Reaction time premature initiations2.44.46.0-2.0-2.32.3-2.12.11.8-2.12.01.91.9-1.8-2.12.5
Std. dev. reaction times0.10.20.70.00.8-0.80.00.0-0.1-0.1-0.3-0.3-0.00.30.5-0.6
Reaction time trials completed0.40.81.8-0.8-0.40.4-1.11.10.9-1.01.00.61.0-1.3-0.50.8
Reaction time trials AUC0.30.71.8-0.6-0.30.3-1.01.00.7-0.90.90.60.9-1.3-0.50.7
Run reversals in cocaine runway, females0.10.10.7-0.8-0.10.10.1-0.10.5-0.3-0.00.30.30.4-0.20.3
Run reversals in cocaine runway, males0.00.00.00.10.1-0.1-0.1-0.00.00.1-0.1-0.10.00.00.10.0
Latency to leave start box in cocaine runway0.20.20.60.2-0.10.10.8-0.8-0.10.5-0.5-0.4-0.70.60.4-0.1
Latency to leave start box in cocaine runway, F0.40.51.10.80.1-0.11.0-0.9-0.70.7-0.9-0.6-0.91.10.2-0.1
Latency to leave start box in cocaine runway, M0.10.10.4-0.3-0.20.20.4-0.40.50.3-0.2-0.3-0.5-0.00.7-0.3
Std. dev. time between licks in bursts0.81.11.6-1.2-0.90.9-1.11.11.2-1.11.10.91.3-1.2-0.71.0
Total sessions with >9 infusions0.00.10.2-0.1-0.40.4-0.10.10.20.10.10.1-0.2-0.1-0.10.3
Short access day 1 total inactive lever presses2.22.94.21.81.8-1.82.1-2.0-1.21.7-1.6-1.8-1.61.31.8-1.4
Short access day 10 total inactive lever presses0.10.20.40.6-0.60.60.6-0.6-0.10.5-0.1-0.4-0.40.00.10.1
Short access day 1 total infusions0.00.10.20.2-0.40.40.3-0.3-0.40.20.00.1-0.20.0-0.20.1
Short access day 10 total infusions0.00.00.1-0.20.2-0.2-0.00.00.2-0.00.00.10.1-0.10.10.1
Short access total infusions0.20.20.30.50.5-0.50.6-0.5-0.50.6-0.4-0.3-0.50.20.5-0.4
Short access day 1 locomotion0.81.01.4-0.7-1.11.1-1.11.10.3-0.71.11.21.0-1.2-1.11.1
Short access day 10 total locomotion1.62.94.2-1.9-1.71.7-1.81.71.6-1.31.91.81.7-2.1-1.31.7
Short access total locomotion2.53.14.0-1.7-2.02.0-1.71.71.6-1.31.81.71.6-2.0-1.51.9
One hour access (0.3 mA shock)1.61.83.51.11.9-1.91.1-1.0-0.91.2-1.2-1.3-1.11.01.6-1.6
Compulsive drug intake2.42.94.2-1.8-2.02.0-1.81.71.2-1.61.81.91.5-1.5-1.71.4
One hour access (shock baseline)3.85.98.52.32.9-2.92.4-2.4-1.82.4-2.3-2.4-2.21.92.7-2.7
Social response proportion0.20.20.6-0.40.6-0.6-0.30.40.8-0.20.1-0.20.7-0.40.4-0.1
Social responses0.20.30.9-0.01.0-1.0-0.10.10.6-0.1-0.2-0.50.4-0.10.7-0.4
Social time0.70.92.5-1.2-0.10.1-1.11.10.9-1.01.00.91.6-1.1-0.60.6
Soleus weight0.41.25.42.11.1-1.10.7-0.7-2.30.7-0.5-0.5-0.70.30.3-0.8
Bone: stiffness0.10.10.3-0.2-0.50.5-0.10.10.3-0.1-0.10.0-0.30.4-0.40.4
Tibialis anterior weight1.55.06.92.62.4-2.42.3-2.3-2.02.2-2.2-2.2-2.32.02.0-2.1
Time to tail flick, vehicle, before self-admin0.10.10.30.00.6-0.6-0.00.0-0.3-0.1-0.20.10.20.5-0.30.3
Time to tail flick, vehicle, after self-admin0.10.10.5-0.6-0.20.20.4-0.40.70.3-0.2-0.1-0.20.40.20.2
Time to tail flick, test, before self-admin0.30.30.7-0.2-0.80.8-0.40.40.2-0.40.60.50.4-0.7-0.50.6
Time to tail flick, test, after self-admin1.01.02.31.51.0-1.01.1-1.1-1.10.9-0.8-1.0-1.10.40.9-0.9
Delta time to tail flick, vehicle, before/after SA0.20.21.0-0.7-0.50.50.2-0.21.00.20.0-0.1-0.2-0.10.40.1
Delta time to tail flick, test, before/after SA0.70.81.10.91.1-1.10.9-0.9-0.60.6-0.8-0.9-0.90.61.0-0.9
Tibia length0.30.82.00.1-1.01.0-0.70.7-1.2-0.70.81.10.8-0.5-1.40.7
Ambulatory time before self-admin0.00.00.1-0.20.4-0.4-0.10.1-0.20.0-0.00.1-0.0-0.10.3-0.2
Ambulatory time after self-admin0.00.00.1-0.30.2-0.20.0-0.0-0.20.00.10.3-0.1-0.10.1-0.1
Bone: tissue strength1.01.02.2-0.5-0.20.2-1.31.30.1-1.21.21.11.5-1.4-1.00.8
Total heroin consumption0.30.40.6-0.4-0.50.5-0.70.7-0.0-0.70.80.80.5-0.8-0.70.4
Bone: trabecular number0.20.40.8-0.1-0.90.9-0.40.4-0.7-0.30.70.90.6-0.7-0.70.2
Bone: trabecular spacing0.60.71.80.51.3-1.30.6-0.60.30.5-1.0-1.1-0.60.91.0-0.4
Bone: trabecular thickness1.62.03.5-0.8-1.61.6-1.31.3-0.5-1.21.71.91.4-1.6-1.70.8
Bone: trabecular tissue density0.10.10.4-0.60.4-0.4-0.40.40.6-0.40.20.10.2-0.10.0-0.0
Water consumed over 24 hours1.01.42.6-1.30.0-0.0-1.51.51.6-1.51.10.81.2-1.6-0.30.6
Number of responses in last shaping day0.20.20.5-0.4-0.10.10.5-0.40.60.5-0.5-0.4-0.40.70.30.1