LOC102548950

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression LOC102548950 0.13 0.05 1.8e-14 0.11 0.11 0.1 0.1 3.5e-12 6.5e-12 8.7e-11 1.6e-11
2 Adipose gene expression LOC102548950 0.09 0.04 9.6e-11 0.06 0.08 0.08 0.08 1.0e-06 2.2e-09 2.8e-09 1.5e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density0.30.50.70.6-0.8
Area under the delay curve0.10.10.2-0.1-0.4
BMI with tail1.65.35.8-2.22.4
BMI without tail3.57.37.4-2.72.7
Body weight8.234.338.2-6.25.5
Weight adjusted by age3.03.43.6-1.81.9
Bone surface0.00.00.00.0-0.1
Bone volume0.00.00.0-0.1-0.1
Breakpoint value in progressive ratio session0.20.20.30.6-0.2
Number of licking bursts0.10.10.10.40.0
Context. condit. distance diff. score1.72.12.1-1.51.4
Locomotion velocity, session 10.00.00.00.20.2
Locomotion distance, session 10.30.40.6-0.40.8
Locomotion velocity, session 20.00.00.00.1-0.2
Locomotion distance, session 20.50.71.0-0.61.0
Locomotion velocity, session 33.03.54.9-1.42.2
Locomotion distance, session 32.02.12.5-1.31.6
Stereotopy head waving bouts, day 31.82.12.81.7-1.2
Stereotopy head waving duration, day 30.60.71.11.0-0.5
Locomotion velocity, session 72.83.03.0-1.71.7
Locomotion distance, session 70.81.11.2-0.91.1
Stereotopy head waving bouts, day 70.00.10.1-0.10.3
Stereotopy head waving duration, day 70.00.00.00.20.2
Locomotion velocity, session 81.61.92.2-1.51.3
Locomotion distance, session 86.29.19.8-2.93.1
Degree of sensitization distance0.30.30.30.6-0.5
Degree of sensitization stereotypy0.00.00.00.1-0.0
Conditioned locomotion0.00.00.1-0.20.3
Cocaine response after cond. corrected1.21.32.00.8-1.4
Cocaine response after cond. not corrected0.80.91.40.6-1.2
Cocaine response before conditioning0.10.20.2-0.30.5
Saline control response0.00.10.1-0.30.2
Bone: connectivity density0.81.21.41.0-1.2
Bone: cortical apparent density1.92.52.7-1.61.5
Bone: cortical area0.40.50.7-0.60.8
Bone: cortical porosity0.30.30.40.4-0.7
Bone: cortical porosity0.10.10.20.2-0.4
Bone: cortical thickness0.00.10.1-0.20.4
Bone: cortical thickness0.70.80.90.9-0.9
Bone: cortical tissue density2.12.73.0-1.71.6
Condit. Reinf. active minus inactive responses0.20.20.20.4-0.5
Condit. Reinf. active-inactive response ratio1.41.51.81.1-1.3
Condit. Reinf. active responses0.91.11.31.1-1.0
Condit. Reinf. inactive responses0.60.70.91.0-0.7
Incentive salience index mean0.00.00.0-0.00.0
Condit. Reinf. lever presses0.30.50.5-0.60.7
Condit. Reinf. active minus inactive responses0.00.00.0-0.20.1
Condit. Reinf. active-inactive response ratio0.00.00.0-0.00.2
Condit. Reinf. active responses0.10.10.1-0.30.3
Condit. Reinf. inactive responses0.00.00.0-0.1-0.0
Condit. Reinf. lever presses0.10.20.2-0.50.3
Condit. Reinf. lever reinforcers received0.30.40.5-0.60.7
Conditioned reinforcement - actives0.00.00.00.1-0.1
Conditioned reinforcement - inactives0.20.20.40.3-0.6
Conditioned locomotion0.30.40.5-0.70.6
Patch foraging indifference point 0 sec0.00.00.0-0.20.2
Patch foraging indifference point AUC0.00.00.0-0.10.1
Delay disc. indifference point, 0s delay0.30.40.70.2-0.8
Delay disc. indifference point, 16s delay0.00.00.0-0.00.0
Delay disc. indifference point, 2s delay0.91.01.4-1.20.7
Delay disc. indifference point, 24s delay2.42.32.4-1.51.5
Delay disc. indifference point, 4s delay0.80.81.50.4-1.2
Delay disc. indifference point, 8s delay0.40.50.90.2-0.9
Indifference point function ln k0.00.00.1-0.3-0.2
Indifference point function log k0.00.00.1-0.3-0.2
Patch foraging total patch changes 0 sec0.10.10.2-0.30.4
Patch foraging total patch changes 12 sec0.50.70.8-0.90.7
Patch foraging total patch changes 18 sec0.00.00.0-0.10.0
Patch foraging total patch changes 24 sec0.50.60.8-0.90.7
Patch foraging total patch changes 6 sec0.00.00.0-0.0-0.0
Patch foraging time to switch 0 sec0.71.01.01.0-1.0
Patch foraging water rate 0 sec3.35.35.5-2.42.2
Patch foraging water rate 12 sec0.91.41.5-1.21.1
Patch foraging water rate 18 sec0.20.20.4-0.30.6
Patch foraging water rate 24 sec5.47.58.6-2.92.5
Patch foraging water rate 6 sec7.110.412.7-3.62.8
Seeking ratio, delayed vs. immediate footshock0.80.91.30.7-1.1
Distance traveled before self-admin0.20.20.4-0.10.6
Distance traveled after self-admin0.70.81.5-0.41.2
Extensor digitorum longus weight0.10.40.60.7-0.5
Bone: elastic displacement2.42.73.01.7-1.6
Bone: elastic work1.92.52.81.7-1.5
Bone: endosteal estimation0.20.50.70.8-0.5
Bone: endosteal perimeter0.61.21.3-1.21.0
Epididymis fat weight3.58.29.2-2.73.0
Delta time in closed arm before/after self-admin0.10.10.10.3-0.0
Delta time in open arm before/after self-admin0.30.30.40.3-0.7
Diff in mean of infusions in LGA sessions1.31.41.81.3-1.0
Delay discount exponential model param0.10.10.10.30.3
Extinction: sum of active levers before priming0.50.50.70.9-0.6
Active lever presses in extinction session 60.20.20.3-0.30.5
Bone: final force0.10.20.30.5-0.2
Bone: final moment0.20.30.40.6-0.3
Food consumed during 24 hour testing period0.10.10.3-0.5-0.0
Glucose0.00.00.0-0.2-0.1
Heart weight0.10.10.2-0.40.3
Delay discount hyperbolic model param0.10.10.20.40.3
Intermittent access intake day 1-15 change0.10.10.10.4-0.3
Intermittent access intake escalation0.20.20.20.4-0.4
Intermittent access intake escalation 20.00.00.10.3-0.1
Intermitt. access day 1 inactive lever presses7.58.08.82.7-3.0
Intermitt. access day 15 inactive lever presses0.00.00.0-0.20.1
Intermitt. access escalation Index0.10.10.10.2-0.4
Intermittent access day 1 total infusions0.20.30.4-0.60.4
Intermittent access day 15 total infusions0.50.50.6-0.80.7
Intermittent access terminal intake (last 3 days)0.91.01.2-1.11.0
Intermittent access total infusions0.40.50.6-0.80.6
Intermittent access day 1 locomotion0.10.10.2-0.40.0
Intermittent access day 15 total locomotion0.60.60.8-0.90.7
Intermittent access total locomotion0.10.10.3-0.50.2
Intermittent access standard deviation0.10.10.1-0.30.3
Left kidney weight3.29.19.7-3.12.9
Right kidney weight2.26.36.5-2.52.5
Cocaine induced anxiety0.10.10.1-0.30.3
Post-drug Anxiety0.00.00.00.0-0.1
Baseline Anxiety0.10.10.10.4-0.3
Tail length6.218.722.2-4.73.9
Length with tail10.638.746.0-6.85.6
Length without tail6.414.016.3-4.03.4
Times rat made contact with spout0.00.10.10.2-0.2
Lifetime Intake1.11.21.5-1.21.0
Liver weight, left1.11.72.0-1.21.4
Liver weight, right0.91.51.6-1.31.2
Locomotor activity5.48.69.6-3.12.8
Locomotor testing distance3.05.05.2-2.32.2
Locomotor testing rearing0.40.50.7-0.70.8
Locomotion in novel chamber2.32.93.2-1.61.8
Locomotion in novel chamber post-restriction0.40.50.70.6-0.8
Fecal boli incidents, locomotor time 10.10.10.2-0.2-0.4
Change in fecal boli incidents, locomotor task0.10.10.2-0.00.4
Time >=10cm from walls, locomotor time 10.00.00.00.0-0.0
Bouts of movement, locomotor time 10.60.71.00.5-1.0
Total resting periods, locomotor time 10.50.60.80.6-0.9
Rest time, locomotor task time 10.91.01.00.9-1.0
Distance moved, locomotor task time 10.10.10.2-0.30.4
Vertical activity count, locomotor time 12.62.72.9-1.71.6
Time >=10cm from walls, locomotor time 20.20.20.30.3-0.6
Bouts of movement, locomotor time 20.10.20.2-0.40.4
Total resting periods, locomotor time 20.20.20.2-0.50.4
Rest time, locomotor task time 20.10.20.30.5-0.2
Distance moved, locomotor task time 20.00.00.00.0-0.1
Vertical activity count, locomotor time 20.91.01.6-1.30.7
Light reinforcement 11.83.23.6-1.71.9
Light reinforcement 20.70.91.31.2-0.7
Bone: marrow area0.20.40.60.8-0.5
Bone: maximum diameter0.71.31.3-1.11.2
Bone: maximum force0.20.40.50.7-0.5
Bone: maximum moment0.30.50.70.8-0.6
Mean time between licks in bursts0.40.50.9-1.00.3
Mean num. licks in bursts0.10.10.20.2-0.5
Cd content in liver0.10.10.2-0.5-0.0
Co content in liver1.11.22.1-1.50.6
Cu content in liver0.10.10.1-0.30.3
Fe content in liver0.40.50.6-0.70.8
K content in liver0.40.40.40.6-0.6
Mg content in liver0.10.10.10.3-0.2
Mn content in liver0.00.00.10.30.1
Na content in liver0.00.00.00.0-0.1
Rb content in liver2.22.73.31.5-1.8
Se content in liver1.72.12.6-1.21.6
Sr content in liver0.10.10.10.3-0.1
Zn content in liver1.11.21.5-1.21.0
Bone: minimum diameter2.64.95.4-2.12.3
Time in familiar zone, hab. session 10.40.40.4-0.60.6
Time in novel zone, hab. session 11.91.91.91.4-1.4
Total zone transitions, hab. session 14.15.76.6-2.22.6
Total locomotion distance, hab. session 15.17.28.1-2.52.8
Locomotion velocity, hab. session 17.09.911.2-2.93.3
Time in familiar zone, hab. session 20.10.10.1-0.20.4
Time in novel zone, hab. session 20.50.50.60.6-0.8
Total zone transitions, hab. session 21.21.62.1-1.01.5
Total locomotion distance, hab. session 20.91.21.6-0.91.3
Locomotion velocity, hab. session 21.41.82.4-1.11.5
Novel to familiar place preference ratio0.20.20.5-0.70.1
Novelty place preference0.10.10.3-0.5-0.0
Time in novel zone, NPP test0.10.10.3-0.50.0
Total zone transitions, NPP test1.62.22.6-1.31.6
Total locomotion distance, NPP test1.82.43.0-1.41.7
Locomotion velocity, NPP test1.31.92.4-1.21.6
Intraocular pressure1.92.62.81.5-1.7
Delta distance traveled before/after self-admin0.10.10.2-0.10.4
Delta ambulatory time before/after self-admin0.10.10.20.4-0.2
Parametrial fat weight0.40.81.1-0.61.1
Pavlov. Cond. lever latency0.40.50.8-0.90.4
Pavlov. Cond. magazine entry latency0.00.00.00.10.1
Pavlov. Cond. change in total contacts0.40.40.60.8-0.4
Pavlov. Cond. index score0.10.10.20.40.0
Pavlov. Cond. latency score0.10.10.30.5-0.0
Pavlov. Cond. lever contacts0.00.00.00.00.2
Pavlov. Cond. magazine entry number0.00.00.1-0.0-0.3
Pavlov. Cond. intertrial magazine entries0.10.10.2-0.20.4
Pavlov. Cond. lever-magazine prob. diff.0.00.00.10.30.1
Pavlov. Cond. response bias0.00.00.1-0.00.3
Pavlov. Cond. lever latency0.10.10.30.5-0.2
Pavlov. Cond. magazine entry latency1.01.11.4-1.21.0
Pavlov. Cond. change in total contacts2.53.54.7-2.21.5
Pavlov. Cond. index score1.11.41.9-1.40.9
Pavlov. Cond. latency score0.81.01.4-1.20.8
Pavlov. Cond. lever contacts0.10.20.3-0.60.1
Pavlov. Cond. magazine entry number1.72.12.51.6-1.3
Pavlov. Cond. intertrial magazine entries0.20.20.3-0.50.5
Pavlov. Cond. lever-magazine prob. diff.1.01.21.7-1.30.9
Pavlov. Cond. response bias0.60.81.2-1.10.6
Time in closed arm before self-admin0.81.01.2-1.10.8
Time in closed arm after self-admin0.20.20.2-0.30.5
Time in open arm before self-admin0.00.10.10.30.1
Time in open arm after self-admin0.10.20.20.3-0.5
Bone: periosteal estimation0.10.20.3-0.20.5
Bone: periosteal perimeter0.40.70.8-0.80.9
Bone: post-yield work0.40.50.70.8-0.6
Progressive ratio test 1 active lever presses0.60.60.8-0.90.7
Progressive ratio test 1 breakpoint0.80.80.9-1.00.8
Progressive ratio test 1 inactive lever presses0.30.30.30.5-0.6
Progressive ratio test 2 active lever presses0.60.70.7-0.90.8
Progressive ratio test 2 breakpoint0.50.50.6-0.80.7
Progressive ratio test 2 inactive lever presses0.00.00.00.00.0
Incentive Sensitization - Responses0.30.30.3-0.60.6
Incentive Sensitization - Breakpoint0.20.20.3-0.50.5
Sum of active levers in priming session hrs 5-60.10.10.1-0.30.2
Progressive ratio0.10.10.20.40.1
Food seeking constrained by brief footshock0.10.10.1-0.30.2
Seeking ratio, punishment vs. effort0.10.10.1-0.4-0.0
Retroperitoneal fat weight4.113.313.8-3.73.6
Reaction time number correct0.50.80.9-0.81.0
Reaction time mean minus median0.40.50.60.8-0.7
Reaction time mean minus median AUC0.50.60.80.9-0.6
Reaction time num false alarms2.02.72.81.7-1.6
Reaction time num false alarms AUC2.43.33.51.8-1.9
Reaction time trials correct on left0.50.80.9-0.81.0
Reaction time trials on left0.50.70.8-0.70.9
Reaction time mean0.30.40.50.7-0.6
Reaction time mean AUC0.50.60.70.8-0.8
Median of all reaction times0.20.30.30.5-0.5
Reaction time omissions1.92.63.41.8-1.3
Reaction time false alarm rate3.34.54.72.1-2.2
Reaction time premature initiation rate0.30.40.5-0.60.7
Reaction time premature initiations0.81.21.3-1.01.1
Std. dev. reaction times0.91.21.41.2-1.0
Reaction time trials completed0.50.70.8-0.70.9
Reaction time trials AUC0.50.80.9-0.81.0
Run reversals in cocaine runway, females0.50.50.8-0.50.9
Run reversals in cocaine runway, males0.10.10.2-0.30.4
Latency to leave start box in cocaine runway1.51.71.9-1.41.2
Latency to leave start box in cocaine runway, F0.20.30.3-0.50.6
Latency to leave start box in cocaine runway, M3.02.93.4-1.91.5
Std. dev. time between licks in bursts0.20.30.5-0.70.1
Total sessions with >9 infusions1.21.31.3-1.21.1
Short access day 1 total inactive lever presses2.12.32.51.6-1.5
Short access day 10 total inactive lever presses0.20.20.30.4-0.5
Short access day 1 total infusions0.50.50.7-0.80.7
Short access day 10 total infusions1.41.61.9-1.41.1
Short access total infusions2.02.32.7-1.61.4
Short access day 1 locomotion0.40.50.5-0.70.7
Short access day 10 total locomotion1.21.41.61.0-1.3
Short access total locomotion0.10.10.10.1-0.3
One hour access (0.3 mA shock)2.42.92.9-1.71.7
Compulsive drug intake1.11.11.2-1.01.1
One hour access (shock baseline)0.40.50.5-0.70.7
Social response proportion1.71.82.4-1.51.1
Social responses3.95.05.2-2.32.2
Social time0.30.30.60.8-0.2
Soleus weight0.10.20.3-0.10.5
Bone: stiffness0.00.00.0-0.00.2
Tibialis anterior weight0.82.93.81.9-1.4
Time to tail flick, vehicle, before self-admin1.01.11.8-1.30.6
Time to tail flick, vehicle, after self-admin3.63.84.41.8-2.1
Time to tail flick, test, before self-admin0.60.60.7-0.70.8
Time to tail flick, test, after self-admin0.40.50.5-0.70.7
Delta time to tail flick, vehicle, before/after SA4.24.14.62.2-1.9
Delta time to tail flick, test, before/after SA0.00.00.0-0.1-0.1
Tibia length7.922.324.9-5.04.4
Ambulatory time before self-admin0.10.10.10.20.2
Ambulatory time after self-admin1.41.62.5-0.81.6
Bone: tissue strength0.40.40.40.6-0.6
Total heroin consumption0.80.91.2-0.71.1
Bone: trabecular number0.91.41.51.1-1.2
Bone: trabecular spacing0.50.70.8-0.90.8
Bone: trabecular thickness0.10.10.1-0.30.2
Bone: trabecular tissue density0.30.40.6-0.80.5
Water consumed over 24 hours0.60.71.00.6-1.0
Number of responses in last shaping day0.10.10.1-0.40.2