LOC102548260

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL intron excision ratio chr7_26674153_26674654 0.05 0.04 3.2e-03 0 0.01 0 0 1.5e-01 7.2e-02 1.6e-01 1.9e-01
2 Eye alternative polyA XR_005486829.1 0.44 0.17 2.9e-03 0.06 0.12 0.03 0.11 5.0e-02 6.8e-03 1.2e-01 9.7e-03
3 PL intron excision ratio chr7_26674062_26674654 0.05 0.04 2.2e-03 0 0 0 0 3.4e-01 7.8e-02 1.2e-01 2.1e-01
4 Eye alternative polyA XR_005486834.1 0.42 0.18 4.8e-03 0.11 0.12 -0.02 0.09 9.7e-03 7.3e-03 7.2e-01 2.0e-02
5 Brain gene expression LOC102548260 0.33 0.08 0.0e+00 0.35 0.38 0.38 0.39 5.5e-34 2.1e-37 5.4e-37 4.5e-38
6 Brain intron excision ratio chr7_26674153_26674654 0.08 0.04 6.3e-06 0.06 0.06 0.07 0.06 2.7e-06 1.4e-06 1.0e-06 2.5e-06
7 Brain intron excision ratio chr7_26673297_26673931 0.25 0.1 0.0e+00 0.21 0.22 0.22 0.22 4.6e-19 1.0e-19 1.0e-19 1.9e-20
8 Brain intron excision ratio chr7_26673343_26673931 0.07 0.04 1.1e-05 0.06 0.05 0.04 0.06 2.8e-06 2.6e-05 2.0e-04 4.4e-06
9 PL gene expression LOC102548260 0.05 0.03 9.3e-04 0.03 0.03 0.03 0.03 7.5e-04 7.3e-04 8.0e-04 8.2e-04
10 Brain mRNA stability LOC102548260 0.22 0.08 0.0e+00 0.2 0.21 0.19 0.21 1.3e-18 2.3e-19 2.7e-17 2.6e-19
11 Brain intron excision ratio chr7_26674062_26674654 0.08 0.04 2.3e-06 0.06 0.07 0.07 0.06 1.5e-06 2.2e-07 5.8e-07 3.7e-06
12 Brain intron excision ratio chr7_26673396_26673931 0.15 0.07 2.3e-09 0.1 0.11 0.1 0.1 4.1e-09 1.1e-10 8.5e-10 4.2e-09
13 Eye intron excision ratio chr7_26701190_26701308 0.44 0.14 1.5e-03 0.2 0.07 0.12 0.13 4.4e-04 3.3e-02 7.4e-03 4.6e-03
14 NAcc intron excision ratio chr7_26701190_26703708 0.05 0.03 4.0e-04 0 0.03 0.02 0.02 1.1e-01 1.6e-04 1.3e-03 2.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.20.31.5-0.7-0.70.80.6-0.40.4-0.4-0.41.2-0.20.20.1-0.40.3
Area under the delay curve0.20.20.80.00.2-0.2-0.20.6-0.40.50.40.10.20.1-0.20.9-0.9
BMI with tail0.20.72.41.51.1-1.4-1.20.3-0.10.40.20.90.20.30.41.0-0.9
BMI without tail0.40.72.71.61.2-1.5-1.30.6-0.40.60.50.00.4-0.2-0.10.8-0.4
Body weight2.711.329.55.44.7-5.1-4.72.9-2.82.92.9-1.42.6-2.1-2.12.5-0.8
Weight adjusted by age2.93.34.72.02.2-1.9-2.11.9-2.02.01.9-0.22.0-2.0-1.91.40.5
Bone surface0.10.21.70.10.2-0.1-0.30.5-0.30.30.31.30.5-0.2-0.20.1-0.1
Bone volume0.10.22.5-0.00.00.1-0.10.2-0.10.10.11.60.2-0.1-0.10.00.0
Breakpoint value in progressive ratio session0.40.51.4-0.7-0.60.80.6-0.70.6-0.8-0.60.4-0.30.30.6-1.20.9
Number of licking bursts0.30.41.20.30.5-0.2-0.50.5-0.60.50.50.00.9-1.0-0.80.21.1
Context. condit. distance diff. score3.03.65.82.42.4-2.4-2.42.0-2.02.12.00.11.8-1.4-1.51.6-0.8
Locomotion velocity, session 13.53.85.8-1.8-2.21.82.2-2.32.4-2.1-2.4-1.0-2.42.22.2-0.2-0.2
Locomotion distance, session 11.21.52.5-1.5-1.61.41.6-1.41.4-1.2-1.4-0.2-1.41.21.10.20.0
Locomotion velocity, session 20.70.81.70.2-0.3-0.20.3-1.11.0-1.0-1.0-1.0-1.21.31.10.7-1.2
Locomotion distance, session 21.41.93.0-1.2-1.51.21.5-1.71.7-1.6-1.70.1-1.71.61.60.2-0.3
Locomotion velocity, session 30.70.81.5-0.3-0.70.40.7-1.21.2-1.1-1.2-0.7-1.21.11.2-0.60.1
Locomotion distance, session 30.20.31.50.70.3-0.5-0.3-0.40.4-0.3-0.4-1.2-0.30.10.3-0.30.7
Stereotopy head waving bouts, day 30.20.32.1-0.7-0.30.70.30.1-0.20.20.21.40.4-0.3-0.10.50.5
Stereotopy head waving duration, day 30.30.31.2-0.9-0.70.80.6-0.30.3-0.3-0.31.1-0.30.50.50.4-0.3
Locomotion velocity, session 70.50.51.90.90.3-0.9-0.3-0.30.4-0.2-0.4-1.4-0.80.90.60.9-1.0
Locomotion distance, session 70.20.32.90.60.2-0.6-0.1-0.20.3-0.1-0.2-1.7-0.50.40.2-0.1-0.4
Stereotopy head waving bouts, day 72.12.44.52.01.8-2.1-1.91.5-1.41.61.5-0.81.0-0.6-1.02.0-1.5
Stereotopy head waving duration, day 71.01.32.51.51.3-1.5-1.41.0-1.01.11.1-0.50.7-0.4-0.61.6-1.1
Locomotion velocity, session 80.30.42.1-0.1-0.40.10.4-0.70.7-0.6-0.8-1.4-0.70.60.50.5-0.2
Locomotion distance, session 80.60.82.41.61.2-1.5-1.20.6-0.50.70.5-0.10.3-0.1-0.11.4-0.7
Degree of sensitization distance0.10.10.3-0.4-0.30.30.30.2-0.20.20.2-0.50.1-0.2-0.5-0.0-0.3
Degree of sensitization stereotypy2.93.25.42.22.1-2.3-2.11.9-1.81.91.8-1.11.4-1.1-1.51.9-1.3
Conditioned locomotion1.11.32.20.81.2-0.7-1.21.3-1.31.31.31.01.5-1.4-1.10.60.8
Cocaine response after cond. corrected0.80.94.60.40.5-0.5-0.40.9-0.90.80.9-2.10.8-1.3-1.5-0.10.4
Cocaine response after cond. not corrected2.02.25.10.61.0-0.8-0.91.7-1.81.81.7-1.71.7-2.0-2.30.80.5
Cocaine response before conditioning1.41.74.00.61.0-0.7-1.01.5-1.51.61.61.51.4-1.1-1.12.0-0.2
Saline control response0.50.61.50.20.6-0.3-0.50.8-0.90.90.8-0.51.1-1.2-1.10.30.7
Bone: connectivity density0.20.30.7-0.8-0.40.70.40.1-0.30.10.2-0.10.5-0.8-0.8-0.60.7
Bone: cortical apparent density0.10.20.40.60.3-0.5-0.3-0.60.4-0.6-0.4-0.3-0.40.30.4-0.20.0
Bone: cortical area0.40.60.90.80.9-0.7-0.90.8-0.70.50.70.30.9-1.0-0.8-0.70.7
Bone: cortical porosity0.10.10.4-0.4-0.30.30.30.10.00.00.00.3-0.20.3-0.00.6-0.7
Bone: cortical porosity0.10.10.4-0.5-0.40.40.40.10.1-0.1-0.10.6-0.20.30.00.6-0.4
Bone: cortical thickness0.20.30.90.90.8-0.9-0.80.4-0.30.10.40.10.3-0.3-0.3-0.5-0.2
Bone: cortical thickness0.10.10.3-0.4-0.50.30.5-0.40.4-0.4-0.5-0.3-0.50.40.2-0.1-0.3
Bone: cortical tissue density0.20.20.50.60.2-0.4-0.2-0.70.5-0.6-0.5-0.4-0.50.40.5-0.20.0
Condit. Reinf. active minus inactive responses2.52.86.1-1.7-1.81.51.6-1.41.5-1.4-1.42.5-1.72.21.9-0.1-1.5
Condit. Reinf. active-inactive response ratio2.12.26.7-1.3-1.41.21.3-1.21.2-1.2-1.12.6-1.52.01.7-0.4-1.6
Condit. Reinf. active responses1.82.24.3-2.0-1.81.81.8-1.01.1-1.0-1.02.1-1.31.71.30.3-1.3
Condit. Reinf. inactive responses0.20.20.8-0.9-0.60.70.60.1-0.00.20.0-0.20.1-0.1-0.30.8-0.0
Incentive salience index mean0.91.16.1-1.3-1.11.11.0-0.50.5-0.4-0.42.5-0.61.00.80.5-1.0
Condit. Reinf. lever presses0.91.32.6-0.10.6-0.0-0.61.2-1.31.41.31.61.4-1.3-1.41.50.0
Condit. Reinf. active minus inactive responses0.30.40.8-0.3-0.60.40.5-0.60.8-0.7-0.80.7-0.80.90.90.2-0.0
Condit. Reinf. active-inactive response ratio0.30.30.7-0.2-0.50.20.5-0.70.7-0.7-0.70.1-0.80.80.70.2-0.4
Condit. Reinf. active responses0.20.21.0-0.1-0.30.20.3-0.40.5-0.4-0.51.0-0.50.60.80.30.3
Condit. Reinf. inactive responses0.30.31.10.20.3-0.1-0.30.6-0.60.60.60.60.7-0.8-0.50.31.1
Condit. Reinf. lever presses0.20.20.90.80.5-0.7-0.5-0.20.1-0.1-0.1-0.9-0.20.10.30.40.3
Condit. Reinf. lever reinforcers received0.10.20.80.2-0.1-0.10.1-0.20.4-0.3-0.40.9-0.40.60.70.60.1
Conditioned reinforcement - actives1.51.52.9-1.6-1.61.61.6-1.31.1-1.3-1.20.9-0.70.40.4-1.70.7
Conditioned reinforcement - inactives0.20.20.9-0.7-0.50.60.5-0.40.3-0.4-0.3-0.50.0-0.3-0.5-0.9-0.1
Conditioned locomotion1.31.65.4-1.3-1.41.31.5-1.41.2-1.5-1.3-0.5-0.90.40.4-2.30.8
Patch foraging indifference point 0 sec0.40.71.30.30.7-0.4-0.71.0-1.11.01.10.31.0-0.9-1.01.1-0.2
Patch foraging indifference point AUC0.10.20.9-0.2-0.30.10.3-0.50.3-0.4-0.2-1.0-0.30.20.0-0.5-0.0
Delay disc. indifference point, 0s delay0.20.20.7-0.8-0.60.80.6-0.10.3-0.1-0.3-0.1-0.10.10.2-0.20.3
Delay disc. indifference point, 16s delay0.10.10.2-0.4-0.20.40.20.1-0.00.10.00.30.2-0.3-0.1-0.20.5
Delay disc. indifference point, 2s delay0.70.82.21.00.9-1.1-0.91.0-0.81.00.9-0.70.4-0.1-0.41.5-1.0
Delay disc. indifference point, 24s delay0.80.72.60.30.5-0.5-0.60.9-0.70.80.91.40.5-0.1-0.41.6-1.2
Delay disc. indifference point, 4s delay1.61.73.61.01.2-1.2-1.21.6-1.41.51.50.01.0-0.6-1.21.9-1.7
Delay disc. indifference point, 8s delay0.10.10.4-0.00.1-0.1-0.10.4-0.20.40.3-0.10.00.1-0.10.6-0.5
Indifference point function ln k0.60.91.60.80.9-0.9-0.91.2-1.01.11.00.40.9-0.7-1.01.3-0.6
Indifference point function log k0.60.91.60.80.9-0.9-0.91.2-1.01.11.00.40.9-0.7-1.01.3-0.6
Patch foraging total patch changes 0 sec0.50.81.30.40.8-0.5-0.81.0-1.11.01.10.21.0-1.0-1.11.1-0.2
Patch foraging total patch changes 12 sec0.30.41.11.00.8-1.1-0.90.3-0.50.40.6-0.40.2-0.1-0.20.8-0.7
Patch foraging total patch changes 18 sec2.02.63.61.51.8-1.5-1.81.7-1.91.71.9-0.41.9-1.8-1.81.40.0
Patch foraging total patch changes 24 sec2.02.43.71.31.6-1.4-1.61.7-1.91.81.9-0.11.6-1.4-1.61.9-0.7
Patch foraging total patch changes 6 sec0.10.10.8-0.4-0.20.30.10.1-0.10.10.20.90.10.1-0.00.5-0.4
Patch foraging time to switch 0 sec0.40.62.30.60.7-0.5-0.70.8-0.70.90.71.50.7-0.4-0.31.1-0.1
Patch foraging water rate 0 sec0.10.10.40.2-0.1-0.10.1-0.50.4-0.5-0.4-0.1-0.50.60.6-0.1-0.1
Patch foraging water rate 12 sec0.40.61.71.31.0-1.3-1.00.5-0.40.40.5-0.40.20.1-0.00.7-0.9
Patch foraging water rate 18 sec0.20.21.5-0.3-0.10.50.2-0.0-0.0-0.20.00.50.3-0.5-0.2-0.61.2
Patch foraging water rate 24 sec0.20.32.30.30.2-0.1-0.1-0.1-0.0-0.1-0.0-0.70.2-0.5-0.1-0.81.5
Patch foraging water rate 6 sec0.30.52.11.51.1-1.2-1.10.2-0.20.00.2-0.50.2-0.20.1-0.30.6
Seeking ratio, delayed vs. immediate footshock1.11.31.8-1.1-1.21.01.2-1.31.3-1.3-1.3-0.7-1.21.11.1-1.3-0.2
Distance traveled before self-admin0.50.52.10.30.6-0.2-0.50.6-0.70.70.7-0.30.9-1.2-0.80.11.4
Distance traveled after self-admin1.51.72.71.21.5-1.2-1.51.4-1.51.31.5-0.51.5-1.6-1.70.60.2
Extensor digitorum longus weight0.31.27.2-1.1-1.01.20.9-0.90.8-0.9-0.82.7-0.50.71.0-0.70.6
Bone: elastic displacement5.05.78.7-2.8-2.92.82.9-2.42.5-2.6-2.5-0.4-2.31.92.0-2.70.8
Bone: elastic work1.62.04.0-2.0-1.91.91.9-1.21.3-1.4-1.30.4-1.31.11.0-1.4-0.0
Bone: endosteal estimation0.51.14.8-0.8-0.20.90.20.9-0.70.90.71.21.2-1.5-1.00.12.2
Bone: endosteal perimeter1.12.35.30.71.2-0.6-1.11.7-1.71.71.60.32.0-2.3-1.90.21.9
Epididymis fat weight2.86.513.93.73.6-3.5-3.52.3-2.32.32.3-1.72.3-2.1-1.91.70.3
Delta time in closed arm before/after self-admin1.51.52.1-1.2-1.31.21.3-1.41.4-1.4-1.4-0.2-1.31.21.3-1.30.1
Delta time in open arm before/after self-admin0.20.20.4-0.1-0.40.00.4-0.50.5-0.4-0.5-0.6-0.60.60.4-0.2-0.6
Diff in mean of infusions in LGA sessions0.30.30.9-0.9-0.90.90.8-0.30.4-0.3-0.40.6-0.40.50.40.00.0
Delay discount exponential model param0.40.51.6-0.4-0.50.60.5-0.80.6-0.8-0.7-0.0-0.40.10.4-1.21.1
Extinction: sum of active levers before priming1.21.22.0-1.3-1.41.21.4-1.01.1-1.2-1.00.4-1.21.31.1-0.6-0.7
Active lever presses in extinction session 60.70.72.8-0.6-0.60.40.5-0.40.4-0.4-0.31.7-0.71.20.80.7-1.6
Bone: final force0.81.32.00.81.1-0.7-1.11.3-1.31.31.31.11.4-1.3-1.30.90.3
Bone: final moment0.30.51.00.40.6-0.4-0.60.9-0.80.80.81.01.0-0.9-0.80.50.3
Food consumed during 24 hour testing period0.91.12.40.80.9-0.9-0.91.0-1.01.11.0-1.51.0-1.2-1.40.8-0.2
Glucose0.40.52.80.50.5-0.5-0.50.8-0.81.00.80.40.5-0.4-0.51.7-0.2
Heart weight0.70.92.1-1.0-1.01.11.0-0.80.9-0.9-0.9-1.0-0.70.20.5-1.51.2
Delay discount hyperbolic model param0.60.61.8-0.5-0.60.70.7-1.00.8-1.0-0.90.1-0.50.20.6-1.31.1
Intermittent access intake day 1-15 change0.40.43.20.10.0-0.2-0.10.2-0.1-0.00.21.8-0.10.50.20.7-1.0
Intermittent access intake escalation0.30.31.50.30.3-0.4-0.30.3-0.20.10.41.20.10.3-0.00.8-1.1
Intermittent access intake escalation 20.40.43.4-0.5-0.20.40.10.5-0.40.30.61.80.3-0.1-0.50.8-0.7
Intermitt. access day 1 inactive lever presses1.71.83.0-1.7-1.71.51.7-1.21.2-1.2-1.2-1.6-1.41.31.1-1.1-0.6
Intermitt. access day 15 inactive lever presses1.61.83.81.71.6-1.9-1.61.1-1.11.11.1-1.40.8-0.3-0.81.2-1.9
Intermitt. access escalation Index0.30.20.40.30.3-0.3-0.30.6-0.60.50.7-0.40.5-0.6-0.60.20.5
Intermittent access day 1 total infusions1.72.03.1-1.0-1.50.91.4-1.61.7-1.6-1.6-0.8-1.81.71.6-1.2-0.7
Intermittent access day 15 total infusions1.21.43.2-0.5-1.00.40.9-1.31.3-1.4-1.20.2-1.51.81.5-0.6-1.4
Intermittent access terminal intake (last 3 days)1.21.32.9-0.7-1.10.51.1-1.21.2-1.3-1.10.7-1.41.71.3-0.5-1.5
Intermittent access total infusions1.71.94.1-0.8-1.30.71.3-1.51.5-1.5-1.40.2-1.82.01.6-0.6-1.6
Intermittent access day 1 locomotion0.30.32.7-0.1-0.30.00.3-0.50.4-0.5-0.4-1.6-0.50.30.1-0.8-0.3
Intermittent access day 15 total locomotion0.10.10.30.0-0.1-0.10.1-0.30.2-0.4-0.1-0.2-0.20.2-0.0-0.3-0.6
Intermittent access total locomotion0.70.81.1-0.8-1.00.71.0-1.10.9-1.1-0.9-0.5-1.00.90.7-1.1-0.6
Intermittent access standard deviation0.10.10.4-0.6-0.50.50.5-0.10.2-0.2-0.10.4-0.30.40.20.2-0.4
Left kidney weight1.02.77.22.72.4-2.5-2.31.4-1.31.31.3-1.31.4-1.3-1.10.70.2
Right kidney weight2.05.711.73.43.1-3.2-3.12.3-2.22.22.2-2.02.2-2.2-1.91.20.6
Cocaine induced anxiety0.60.73.81.00.9-1.0-0.80.4-0.50.50.3-2.00.5-0.8-0.8-0.00.3
Post-drug Anxiety0.30.32.40.60.1-0.5-0.1-0.50.4-0.4-0.6-1.5-0.60.40.4-0.40.1
Baseline Anxiety0.10.21.1-0.5-0.40.50.3-0.0-0.0-0.10.11.10.1-0.00.1-0.10.4
Tail length2.16.414.23.83.3-3.5-3.22.3-2.22.22.2-2.52.0-2.2-2.11.20.5
Length with tail3.412.529.55.44.8-5.1-4.73.1-3.12.93.0-3.62.6-2.8-2.81.9-0.1
Length without tail2.65.814.63.83.4-3.7-3.32.0-2.01.92.0-2.01.7-1.5-1.61.6-0.7
Times rat made contact with spout1.51.73.60.71.1-0.8-1.11.5-1.41.41.51.91.3-0.8-1.11.9-1.2
Lifetime Intake0.91.02.0-0.5-1.00.50.9-1.21.2-1.2-1.20.1-1.31.41.2-0.7-0.9
Liver weight, left0.10.21.10.50.4-0.5-0.30.2-0.20.10.2-1.10.1-0.2-0.40.1-0.2
Liver weight, right0.40.61.91.41.2-1.2-1.20.6-0.60.60.60.20.7-0.7-0.40.10.6
Locomotor activity1.42.23.91.91.9-1.9-2.01.6-1.41.41.50.91.4-1.1-1.11.6-0.4
Locomotor testing distance1.01.62.40.81.2-0.8-1.21.6-1.41.51.41.41.5-1.3-1.21.50.1
Locomotor testing rearing0.50.82.5-0.9-0.20.90.30.6-0.80.60.71.21.1-1.3-1.00.01.6
Locomotion in novel chamber0.20.20.8-0.2-0.40.10.3-0.30.4-0.4-0.4-0.1-0.60.90.70.2-0.9
Locomotion in novel chamber post-restriction0.10.10.5-0.7-0.40.60.50.10.10.1-0.2-0.2-0.0-0.2-0.30.00.1
Fecal boli incidents, locomotor time 10.10.10.50.30.4-0.3-0.3-0.1-0.0-0.2-0.0-0.40.3-0.3-0.2-0.70.3
Change in fecal boli incidents, locomotor task0.30.30.7-0.3-0.60.30.6-0.50.4-0.3-0.4-0.2-0.70.80.70.2-0.4
Time >=10cm from walls, locomotor time 11.11.12.11.41.4-1.4-1.40.9-0.90.81.00.40.8-0.4-0.41.3-0.9
Bouts of movement, locomotor time 10.30.31.5-0.20.10.3-0.0-0.0-0.20.10.10.40.6-0.9-0.6-0.71.2
Total resting periods, locomotor time 10.30.31.4-0.10.10.2-0.10.0-0.30.10.30.50.7-1.0-0.7-0.71.2
Rest time, locomotor task time 10.20.20.6-0.8-0.60.80.6-0.40.2-0.4-0.10.3-0.0-0.2-0.1-0.70.6
Distance moved, locomotor task time 10.70.83.00.80.7-0.9-0.80.7-0.40.60.61.30.20.50.31.7-1.3
Vertical activity count, locomotor time 10.60.61.71.30.9-1.2-1.00.20.00.30.00.9-0.10.50.71.0-0.8
Time >=10cm from walls, locomotor time 21.51.63.41.21.4-1.3-1.51.4-1.21.41.30.61.1-0.6-0.81.8-1.2
Bouts of movement, locomotor time 20.40.41.9-0.8-0.70.80.7-0.60.6-0.5-0.61.4-0.30.40.6-0.20.3
Total resting periods, locomotor time 20.30.42.5-0.7-0.50.80.5-0.30.4-0.3-0.41.6-0.10.10.4-0.10.5
Rest time, locomotor task time 21.31.53.8-1.7-1.41.81.4-0.80.8-0.8-0.81.3-0.3-0.10.4-1.31.9
Distance moved, locomotor task time 21.31.63.51.81.6-1.9-1.61.0-1.01.11.1-0.90.6-0.3-0.61.4-1.3
Vertical activity count, locomotor time 21.01.14.12.01.3-1.9-1.4-0.1-0.10.10.1-0.6-0.30.70.60.7-1.4
Light reinforcement 10.61.12.71.61.4-1.4-1.30.4-0.70.40.6-1.60.7-0.9-0.6-0.30.9
Light reinforcement 20.91.21.71.21.3-1.2-1.31.0-1.31.01.3-1.01.2-1.1-1.00.50.3
Bone: marrow area0.41.04.2-0.8-0.20.90.20.9-0.70.90.61.21.1-1.4-0.90.12.0
Bone: maximum diameter0.30.61.20.50.7-0.4-0.70.9-0.80.70.80.61.0-1.1-0.9-0.50.9
Bone: maximum force0.30.51.3-0.00.30.1-0.30.8-0.70.80.70.91.0-1.1-0.90.31.0
Bone: maximum moment0.10.20.9-0.4-0.10.40.10.4-0.30.30.20.90.6-0.7-0.50.00.9
Mean time between licks in bursts4.26.010.8-1.6-2.31.82.2-3.13.0-3.0-3.00.7-2.92.93.3-1.60.2
Mean num. licks in bursts0.30.42.9-0.2-0.1-0.00.00.3-0.10.30.31.2-0.20.60.10.8-1.7
Cd content in liver0.40.41.41.00.8-0.7-0.80.2-0.30.30.20.40.6-0.7-0.10.71.2
Co content in liver0.91.12.51.61.4-1.5-1.40.7-0.90.90.8-1.00.7-0.6-0.60.9-0.3
Cu content in liver0.40.50.9-0.1-0.40.20.4-0.90.9-0.9-0.9-0.9-0.80.70.9-0.80.3
Fe content in liver0.10.21.2-0.1-0.10.00.10.10.00.00.01.1-0.10.30.00.7-0.8
K content in liver1.11.11.90.71.1-0.8-1.11.4-1.31.41.40.31.3-1.0-1.10.7-0.3
Mg content in liver0.20.20.30.10.3-0.2-0.30.5-0.50.50.50.40.5-0.3-0.40.4-0.2
Mn content in liver0.40.52.20.40.2-0.4-0.3-0.20.2-0.1-0.11.5-0.30.80.71.3-1.2
Na content in liver4.34.56.71.92.2-2.1-2.32.6-2.52.62.50.42.1-1.7-2.32.2-1.4
Rb content in liver0.70.92.7-0.8-0.20.80.30.7-0.70.70.6-0.91.0-1.5-1.4-0.61.6
Se content in liver0.81.01.51.11.1-1.2-1.21.0-1.01.01.00.20.7-0.4-0.71.2-1.2
Sr content in liver0.90.84.00.80.8-0.7-0.70.7-0.80.70.7-2.00.8-1.0-1.0-0.10.6
Zn content in liver0.10.10.50.70.5-0.7-0.50.2-0.10.10.1-0.50.00.10.10.1-0.3
Bone: minimum diameter0.50.92.91.71.4-1.4-1.40.7-0.60.50.50.10.8-0.7-0.30.00.7
Time in familiar zone, hab. session 12.01.93.5-0.5-1.10.51.0-1.61.7-1.7-1.6-1.1-1.91.71.7-1.4-0.6
Time in novel zone, hab. session 10.30.20.7-0.8-0.60.80.6-0.20.3-0.2-0.40.6-0.10.00.30.10.8
Total zone transitions, hab. session 11.21.74.2-0.3-0.80.50.7-1.41.6-1.6-1.51.6-1.51.82.00.1-0.4
Total locomotion distance, hab. session 11.01.45.4-0.8-1.00.90.9-1.01.2-1.2-1.12.3-1.01.41.70.1-0.0
Locomotion velocity, hab. session 10.71.07.4-0.7-0.70.80.6-0.70.8-0.8-0.72.7-0.60.91.30.30.1
Time in familiar zone, hab. session 20.90.91.8-0.2-0.70.20.6-1.11.3-1.0-1.2-0.2-1.31.31.3-0.4-0.7
Time in novel zone, hab. session 20.20.20.6-0.8-0.50.70.50.1-0.20.00.20.40.1-0.3-0.3-0.30.6
Total zone transitions, hab. session 20.30.42.1-0.7-0.40.80.4-0.30.3-0.2-0.31.50.2-0.30.10.61.1
Total locomotion distance, hab. session 21.62.15.8-1.8-1.61.91.5-1.31.3-1.3-1.32.4-0.80.81.5-0.41.4
Locomotion velocity, hab. session 21.01.36.0-1.4-1.11.51.0-0.80.8-0.8-0.82.4-0.30.30.9-0.21.4
Novel to familiar place preference ratio4.14.25.92.02.2-2.2-2.22.3-2.42.32.4-1.32.0-1.7-2.22.0-1.1
Novelty place preference3.13.14.11.71.9-1.9-1.81.9-2.02.02.0-1.51.5-1.3-1.81.8-1.1
Time in novel zone, NPP test2.72.83.61.71.8-1.9-1.81.8-1.91.91.9-1.41.4-1.2-1.61.8-1.2
Total zone transitions, NPP test0.50.71.6-0.6-0.70.80.8-1.11.1-1.1-1.2-0.4-0.70.30.8-0.11.3
Total locomotion distance, NPP test0.60.91.7-1.2-1.11.31.1-0.91.0-0.8-1.01.0-0.60.50.9-0.01.1
Locomotion velocity, NPP test0.50.81.8-1.3-1.01.31.0-0.70.7-0.6-0.71.3-0.30.30.60.11.1
Intraocular pressure1.01.32.3-1.5-1.41.51.5-1.01.0-1.0-1.1-1.5-0.90.40.5-1.40.8
Delta distance traveled before/after self-admin0.30.30.70.60.6-0.7-0.60.5-0.60.40.60.10.6-0.5-0.9-0.1-0.6
Delta ambulatory time before/after self-admin0.10.11.2-0.0-0.1-0.10.1-0.00.1-0.2-0.10.4-0.20.3-0.1-0.2-1.1
Parametrial fat weight0.40.92.00.0-0.50.00.4-1.21.1-1.3-1.0-0.1-1.31.41.4-0.8-0.6
Pavlov. Cond. lever latency0.40.51.50.60.1-0.5-0.1-0.60.7-0.7-0.7-1.2-0.80.80.9-0.9-0.2
Pavlov. Cond. magazine entry latency0.40.52.1-0.5-0.50.60.4-0.70.6-0.7-0.61.5-0.40.40.8-0.40.5
Pavlov. Cond. change in total contacts0.60.63.20.20.5-0.3-0.50.6-0.60.70.71.80.6-0.3-0.31.4-0.4
Pavlov. Cond. index score0.20.31.5-0.10.20.0-0.20.4-0.50.50.51.20.6-0.5-0.50.60.0
Pavlov. Cond. latency score0.20.21.5-0.30.00.2-0.10.3-0.40.40.41.20.5-0.5-0.50.50.0
Pavlov. Cond. lever contacts0.20.30.9-0.10.10.0-0.10.5-0.50.60.50.80.5-0.4-0.61.0-0.2
Pavlov. Cond. magazine entry number0.20.32.00.20.3-0.4-0.20.5-0.40.40.4-1.40.3-0.3-0.6-0.1-0.3
Pavlov. Cond. intertrial magazine entries0.30.30.8-0.5-0.60.40.6-0.40.6-0.5-0.6-0.0-0.80.90.7-0.0-0.7
Pavlov. Cond. lever-magazine prob. diff.0.30.41.60.20.5-0.2-0.50.5-0.70.60.71.30.8-0.6-0.50.8-0.0
Pavlov. Cond. response bias0.20.22.2-0.00.00.0-0.10.0-0.00.10.01.50.10.20.20.9-0.2
Pavlov. Cond. lever latency0.10.10.5-0.6-0.40.60.40.00.0-0.0-0.00.70.2-0.2-0.2-0.00.2
Pavlov. Cond. magazine entry latency0.10.10.20.40.4-0.3-0.40.3-0.20.20.20.30.3-0.3-0.20.30.2
Pavlov. Cond. change in total contacts0.30.41.20.50.0-0.5-0.1-0.60.6-0.6-0.60.1-0.91.11.00.1-1.1
Pavlov. Cond. index score0.20.30.80.90.8-0.9-0.80.4-0.40.40.4-0.00.3-0.1-0.20.6-0.3
Pavlov. Cond. latency score0.20.30.60.80.7-0.7-0.70.4-0.40.40.4-0.00.3-0.2-0.20.6-0.2
Pavlov. Cond. lever contacts0.20.30.70.80.3-0.7-0.3-0.50.4-0.5-0.4-0.8-0.60.70.8-0.2-0.3
Pavlov. Cond. magazine entry number0.40.40.6-0.6-0.80.60.8-0.70.7-0.6-0.6-0.7-0.80.70.6-0.6-0.4
Pavlov. Cond. intertrial magazine entries0.30.41.31.10.9-1.1-0.90.3-0.30.40.40.30.20.1-0.10.9-0.8
Pavlov. Cond. lever-magazine prob. diff.0.40.51.11.11.0-1.0-1.00.6-0.60.60.60.10.5-0.3-0.40.9-0.5
Pavlov. Cond. response bias0.20.20.70.80.4-0.7-0.4-0.40.3-0.4-0.4-0.6-0.50.50.6-0.1-0.1
Time in closed arm before self-admin0.30.32.10.50.4-0.3-0.40.3-0.20.40.2-0.10.5-0.8-0.4-0.21.4
Time in closed arm after self-admin0.10.10.70.50.4-0.4-0.40.2-0.10.20.0-0.10.3-0.4-0.1-0.20.8
Time in open arm before self-admin0.30.31.5-0.4-0.10.20.10.4-0.30.30.41.00.10.3-0.10.8-1.2
Time in open arm after self-admin0.30.31.60.50.5-0.6-0.50.4-0.50.40.5-0.00.30.1-0.30.6-1.3
Bone: periosteal estimation0.30.73.1-0.30.10.4-0.00.8-0.60.70.50.91.0-1.3-0.9-0.41.8
Bone: periosteal perimeter1.11.83.50.91.3-0.8-1.31.6-1.61.51.50.51.8-1.9-1.70.21.0
Bone: post-yield work0.10.10.3-0.5-0.30.50.40.10.00.1-0.1-0.40.0-0.3-0.3-0.20.5
Progressive ratio test 1 active lever presses1.41.52.5-0.8-1.20.71.2-1.41.6-1.4-1.5-0.5-1.61.61.3-0.9-0.9
Progressive ratio test 1 breakpoint1.81.93.2-1.0-1.40.91.3-1.51.8-1.6-1.7-0.4-1.71.71.5-1.2-0.7
Progressive ratio test 1 inactive lever presses0.20.20.7-0.4-0.50.30.5-0.40.3-0.4-0.3-0.8-0.30.30.1-0.6-0.4
Progressive ratio test 2 active lever presses3.74.06.5-1.2-1.91.11.8-2.42.4-2.4-2.3-0.0-2.52.62.3-1.7-1.3
Progressive ratio test 2 breakpoint3.13.56.3-1.0-1.80.91.7-2.22.3-2.2-2.20.2-2.42.52.2-1.4-1.5
Progressive ratio test 2 inactive lever presses1.92.24.3-1.1-1.50.91.4-1.61.7-1.6-1.5-0.1-1.92.11.7-0.7-1.6
Incentive Sensitization - Responses1.61.63.4-0.6-1.10.41.1-1.41.5-1.4-1.30.2-1.71.81.4-0.7-1.7
Incentive Sensitization - Breakpoint1.31.33.3-0.4-0.90.20.9-1.21.3-1.3-1.20.2-1.51.71.2-0.6-1.8
Sum of active levers in priming session hrs 5-60.10.10.30.0-0.2-0.00.2-0.30.4-0.4-0.30.3-0.50.50.4-0.1-0.5
Progressive ratio0.70.82.6-1.6-1.41.51.4-0.70.4-0.8-0.40.7-0.60.30.1-0.40.3
Food seeking constrained by brief footshock0.60.82.00.1-0.4-0.20.4-1.01.0-1.0-0.9-0.8-1.31.41.2-0.2-1.0
Seeking ratio, punishment vs. effort0.40.51.40.90.4-0.8-0.4-0.40.6-0.3-0.6-1.2-0.70.91.0-0.1-0.7
Retroperitoneal fat weight0.30.83.21.81.4-1.5-1.30.3-0.40.20.4-1.00.4-0.5-0.0-0.10.9
Reaction time number correct0.81.22.9-1.1-1.21.21.2-0.91.1-1.1-1.2-1.0-0.80.40.7-1.71.3
Reaction time mean minus median0.91.22.4-1.5-1.41.51.4-1.11.0-1.0-1.00.5-0.80.70.8-1.20.6
Reaction time mean minus median AUC1.52.03.5-1.9-1.81.81.7-1.41.4-1.4-1.40.5-1.31.31.4-1.20.1
Reaction time num false alarms0.20.20.7-0.9-0.50.70.60.2-0.10.00.0-0.50.3-0.5-0.6-0.20.2
Reaction time num false alarms AUC0.20.20.8-0.6-0.20.50.30.5-0.40.40.4-0.40.6-0.7-0.90.10.0
Reaction time trials correct on left0.81.22.9-1.1-1.21.21.2-0.91.1-1.1-1.2-1.0-0.80.40.7-1.71.3
Reaction time trials on left0.91.33.1-1.2-1.31.31.3-1.01.1-1.1-1.2-0.9-0.80.40.7-1.81.3
Reaction time mean1.21.72.6-1.2-1.31.31.3-1.51.5-1.4-1.41.0-1.21.21.6-1.30.7
Reaction time mean AUC1.41.82.9-1.2-1.41.31.3-1.61.5-1.5-1.51.0-1.31.31.7-1.40.6
Median of all reaction times1.01.42.6-0.9-1.11.01.0-1.41.4-1.3-1.41.1-1.21.21.6-1.20.5
Reaction time omissions2.12.97.3-2.7-2.22.72.2-1.51.2-1.4-1.30.9-0.70.30.7-1.91.8
Reaction time false alarm rate0.30.41.0-0.30.10.2-0.10.8-0.80.70.80.40.8-0.7-1.00.9-0.4
Reaction time premature initiation rate0.40.52.7-0.4-0.30.60.3-0.40.3-0.4-0.41.20.1-0.30.2-1.01.6
Reaction time premature initiations0.81.14.9-0.8-0.81.10.9-0.80.8-0.8-0.90.3-0.3-0.30.4-1.92.2
Std. dev. reaction times1.31.83.7-1.8-1.61.91.6-1.31.2-1.3-1.20.7-0.80.61.0-1.61.4
Reaction time trials completed0.91.33.1-1.2-1.31.31.3-1.01.1-1.1-1.2-0.9-0.80.40.7-1.81.3
Reaction time trials AUC1.01.53.5-1.2-1.31.31.4-1.11.2-1.2-1.3-0.8-0.90.40.8-1.91.5
Run reversals in cocaine runway, females0.70.74.4-0.2-0.40.60.4-0.50.6-0.6-0.70.4-0.2-0.10.6-1.52.1
Run reversals in cocaine runway, males0.70.63.90.60.6-0.9-0.70.5-0.60.40.7-0.80.20.1-0.70.8-2.0
Latency to leave start box in cocaine runway0.80.91.81.11.1-1.1-1.21.0-0.81.10.80.60.7-0.5-0.51.3-0.6
Latency to leave start box in cocaine runway, F0.20.20.9-0.00.1-0.0-0.10.5-0.30.50.30.70.2-0.1-0.21.0-0.5
Latency to leave start box in cocaine runway, M3.02.85.72.42.3-2.2-2.31.6-1.61.71.6-0.81.6-1.5-1.40.90.2
Std. dev. time between licks in bursts3.03.65.4-1.7-2.01.82.0-2.22.2-2.3-2.3-0.6-1.91.41.9-2.01.5
Total sessions with >9 infusions0.70.81.3-0.9-1.10.81.1-1.01.1-0.8-1.1-0.2-1.11.00.7-0.5-0.6
Short access day 1 total inactive lever presses0.50.51.5-1.2-1.11.01.1-0.50.5-0.6-0.4-0.5-0.60.50.1-0.6-0.6
Short access day 10 total inactive lever presses0.10.10.70.10.1-0.3-0.10.2-0.20.00.2-0.8-0.10.2-0.10.2-0.8
Short access day 1 total infusions1.51.62.8-0.7-1.20.71.2-1.61.6-1.5-1.60.7-1.61.71.6-0.9-0.5
Short access day 10 total infusions0.40.52.70.1-0.3-0.20.3-0.60.6-0.5-0.6-0.1-0.81.10.70.1-1.7
Short access total infusions0.40.50.9-0.1-0.50.10.5-0.80.9-0.8-0.90.4-0.90.90.9-0.5-0.4
Short access day 1 locomotion0.60.61.40.0-0.4-0.10.4-0.81.0-0.8-1.0-0.2-1.01.21.0-0.6-1.0
Short access day 10 total locomotion1.21.33.1-1.7-1.41.71.4-1.00.8-1.0-0.9-0.5-0.50.00.3-1.81.4
Short access total locomotion0.30.30.6-0.5-0.60.40.6-0.40.5-0.5-0.6-0.8-0.40.30.1-0.8-0.0
One hour access (0.3 mA shock)0.60.71.4-0.5-0.70.40.6-0.80.8-0.9-0.81.2-0.91.10.90.0-1.0
Compulsive drug intake0.30.30.80.70.9-0.6-0.90.4-0.60.30.60.00.7-0.6-0.30.30.5
One hour access (shock baseline)0.20.21.3-0.3-0.50.20.4-0.20.3-0.2-0.20.6-0.40.60.20.3-1.1
Social response proportion2.42.64.6-0.8-1.31.11.3-2.02.1-2.0-2.1-0.1-1.81.42.0-2.11.1
Social responses0.20.22.30.10.00.1-0.1-0.30.2-0.2-0.21.50.00.00.4-0.10.6
Social time1.31.73.3-1.8-1.71.81.7-1.11.1-1.1-1.11.5-1.11.01.1-0.80.6
Soleus weight1.13.15.11.52.0-1.4-1.92.0-1.91.91.90.52.3-2.2-2.01.31.0
Bone: stiffness0.81.23.40.81.0-0.6-1.11.0-1.01.10.91.91.3-1.2-0.81.30.8
Tibialis anterior weight0.72.413.1-1.8-1.61.81.5-1.21.1-1.2-1.13.6-0.91.21.3-0.40.0
Time to tail flick, vehicle, before self-admin2.12.13.71.61.7-1.4-1.61.5-1.51.41.4-0.51.8-1.9-1.60.31.3
Time to tail flick, vehicle, after self-admin0.30.30.9-1.0-0.91.00.9-0.40.4-0.4-0.50.5-0.50.30.2-0.20.3
Time to tail flick, test, before self-admin0.00.00.1-0.0-0.00.00.0-0.0-0.1-0.00.1-0.1-0.1-0.1-0.30.2-0.1
Time to tail flick, test, after self-admin0.20.21.00.40.5-0.3-0.50.5-0.40.60.41.00.5-0.4-0.40.60.2
Delta time to tail flick, vehicle, before/after SA2.32.34.3-1.6-1.81.41.8-1.51.5-1.3-1.50.3-2.02.11.60.1-1.5
Delta time to tail flick, test, before/after SA0.10.10.20.40.4-0.3-0.40.5-0.40.50.40.20.4-0.4-0.30.10.3
Tibia length1.33.512.43.52.9-3.2-2.91.3-1.21.11.2-1.01.2-1.2-1.00.10.1
Ambulatory time before self-admin0.70.72.20.30.6-0.2-0.60.8-0.80.80.8-0.51.0-1.3-0.90.21.5
Ambulatory time after self-admin1.71.82.71.41.6-1.5-1.61.5-1.51.41.5-0.41.4-1.4-1.60.8-0.3
Bone: tissue strength1.21.12.6-1.2-1.21.31.2-1.11.0-1.1-1.00.4-0.70.40.7-1.61.1
Total heroin consumption1.92.23.11.51.7-1.6-1.71.8-1.71.71.7-0.21.5-1.3-1.31.5-0.3
Bone: trabecular number0.40.71.9-1.3-1.01.41.0-0.50.3-0.4-0.40.60.0-0.4-0.3-0.91.3
Bone: trabecular spacing0.60.81.90.80.9-1.0-0.91.0-0.90.90.9-0.10.6-0.3-0.71.3-1.4
Bone: trabecular thickness1.01.22.8-0.3-0.70.40.8-1.41.3-1.4-1.3-0.6-1.31.01.3-1.70.4
Bone: trabecular tissue density0.60.92.2-0.1-0.50.10.5-1.01.1-0.9-1.00.7-1.31.51.30.5-1.1
Water consumed over 24 hours1.72.14.01.01.4-1.1-1.31.7-1.61.71.6-0.81.7-1.9-2.00.60.4
Number of responses in last shaping day0.40.42.6-0.6-0.60.30.5-0.30.2-0.4-0.00.5-0.60.80.20.4-1.6