LOC102548046

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	LOC102548046	0.04	0.04	5.3e-04	0.02	0.03	0.03	0.02	5.8e-03	1.0e-03	1.4e-03	6.0e-03
2	Liver	mRNA stability	LOC102548046	0.04	0.03	5.2e-07	0.05	0.05	0.05	0.05	2.5e-06	2.9e-06	6.1e-06	6.7e-06
3	Liver	gene expression	LOC102548046	0.14	0.08	0.0e+00	0.17	0.17	0.17	0.17	1.0e-18	3.5e-18	1.5e-18	1.8e-18

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3
Bone: apparent density	1.0	1.7	2.3	0.8	-1.4	1.5
Area under the delay curve	0.8	0.9	1.7	-1.3	0.7	-0.7
BMI with tail	0.2	0.5	0.8	0.9	0.6	-0.5
BMI without tail	0.9	1.9	3.0	1.7	-1.1	1.2
Body weight	0.5	2.3	3.3	-0.8	1.8	-1.7
Weight adjusted by age	0.1	0.2	0.2	-0.3	0.4	-0.4
Bone surface	0.6	1.1	2.7	-1.6	0.6	-0.6
Bone volume	0.1	0.1	0.4	-0.6	-0.1	0.2
Breakpoint value in progressive ratio session	0.5	0.5	0.8	-0.1	0.9	-0.9
Number of licking bursts	0.0	0.0	0.0	-0.1	-0.1	0.0
Context. condit. distance diff. score	0.4	0.5	0.6	-0.6	0.8	-0.7
Locomotion velocity, session 1	0.2	0.2	0.6	-0.8	0.2	-0.3
Locomotion distance, session 1	2.8	3.6	4.4	2.1	-1.9	1.7
Locomotion velocity, session 2	0.7	0.8	0.9	0.8	-1.0	0.9
Locomotion distance, session 2	6.6	9.2	9.8	3.0	-3.1	3.0
Locomotion velocity, session 3	0.1	0.1	0.2	-0.2	-0.4	0.1
Locomotion distance, session 3	0.4	0.4	0.7	0.8	-0.6	0.4
Stereotopy head waving bouts, day 3	3.1	3.6	4.2	-1.7	2.0	-2.0
Stereotopy head waving duration, day 3	3.1	3.7	3.9	-1.9	2.0	-2.0
Locomotion velocity, session 7	0.1	0.1	0.2	0.1	-0.4	0.4
Locomotion distance, session 7	2.9	3.7	3.8	1.9	-1.9	2.0
Stereotopy head waving bouts, day 7	4.6	5.2	5.8	-2.2	2.4	-2.2
Stereotopy head waving duration, day 7	6.4	7.7	9.2	-3.0	2.7	-2.5
Locomotion velocity, session 8	0.5	0.6	1.3	-1.2	0.5	-0.5
Locomotion distance, session 8	2.2	3.3	4.2	2.1	-1.7	1.7
Degree of sensitization distance	2.8	2.8	3.5	1.3	-1.7	1.9
Degree of sensitization stereotypy	1.7	1.9	2.2	-1.4	1.5	-1.3
Conditioned locomotion	0.1	0.1	0.2	0.5	-0.1	0.2
Cocaine response after cond. corrected	0.5	0.6	0.8	-0.4	0.8	-0.9
Cocaine response after cond. not corrected	0.2	0.2	0.3	-0.4	0.4	-0.5
Cocaine response before conditioning	0.5	0.6	1.0	-0.0	-1.0	0.9
Saline control response	0.4	0.5	0.8	-0.2	-0.9	0.9
Bone: connectivity density	1.7	2.7	3.8	0.7	-1.9	1.9
Bone: cortical apparent density	1.2	1.6	2.3	1.5	-1.0	1.2
Bone: cortical area	3.4	5.1	6.4	-1.7	2.5	-2.4
Bone: cortical porosity	1.9	2.0	3.1	-1.7	1.3	-1.2
Bone: cortical porosity	2.6	2.8	4.2	-2.0	1.5	-1.4
Bone: cortical thickness	0.3	0.5	0.9	0.3	1.0	-0.7
Bone: cortical thickness	0.1	0.1	0.2	0.2	0.5	-0.3
Bone: cortical tissue density	1.3	1.7	2.4	1.5	-1.1	1.3
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	0.2	-0.3	0.5
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.1	-0.1	-0.3	0.4
Condit. Reinf. active responses	0.7	0.9	1.1	0.8	-0.9	1.0
Condit. Reinf. inactive responses	1.1	1.3	1.6	1.2	-1.0	1.1
Incentive salience index mean	0.0	0.0	0.1	-0.0	-0.1	0.3
Condit. Reinf. lever presses	0.1	0.1	0.2	0.3	-0.1	0.4
Condit. Reinf. active minus inactive responses	0.3	0.3	0.7	-0.8	0.3	-0.4
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	-0.5	0.1	-0.1
Condit. Reinf. active responses	0.0	0.1	0.1	-0.0	-0.3	0.2
Condit. Reinf. inactive responses	0.5	0.7	0.9	0.7	-0.9	0.8
Condit. Reinf. lever presses	0.9	1.2	1.4	0.9	-1.2	1.2
Condit. Reinf. lever reinforcers received	0.1	0.1	0.1	0.2	-0.3	0.3
Conditioned reinforcement - actives	0.9	0.9	1.4	1.2	-0.8	0.8
Conditioned reinforcement - inactives	0.2	0.2	0.2	-0.4	0.5	-0.5
Conditioned locomotion	0.9	1.1	1.8	1.3	-0.8	0.8
Patch foraging indifference point 0 sec	0.7	1.2	2.1	1.4	-0.9	0.8
Patch foraging indifference point AUC	2.4	2.8	3.4	1.4	-1.9	1.7
Delay disc. indifference point, 0s delay	0.8	0.9	1.8	-1.3	0.7	-0.6
Delay disc. indifference point, 16s delay	0.3	0.3	0.4	0.4	-0.6	0.6
Delay disc. indifference point, 2s delay	0.2	0.2	0.5	-0.7	0.1	-0.2
Delay disc. indifference point, 24s delay	0.0	0.0	0.0	0.0	-0.2	0.2
Delay disc. indifference point, 4s delay	0.9	1.0	2.0	-1.4	0.7	-0.7
Delay disc. indifference point, 8s delay	3.4	3.5	5.6	-2.4	1.6	-1.6
Indifference point function ln k	0.3	0.4	0.6	0.1	0.8	-0.8
Indifference point function log k	0.3	0.4	0.6	0.1	0.8	-0.8
Patch foraging total patch changes 0 sec	1.1	1.7	2.9	1.7	-1.1	1.1
Patch foraging total patch changes 12 sec	4.2	5.5	6.4	2.5	-2.3	2.2
Patch foraging total patch changes 18 sec	2.0	2.6	2.6	1.6	-1.6	1.6
Patch foraging total patch changes 24 sec	0.1	0.1	0.1	-0.3	0.4	-0.3
Patch foraging total patch changes 6 sec	1.9	2.8	3.3	1.8	-1.6	1.6
Patch foraging time to switch 0 sec	0.2	0.4	0.6	-0.7	0.6	-0.5
Patch foraging water rate 0 sec	0.5	0.8	1.3	1.1	-0.9	0.7
Patch foraging water rate 12 sec	0.2	0.3	0.8	0.9	0.4	-0.2
Patch foraging water rate 18 sec	0.1	0.2	0.3	0.6	-0.2	0.3
Patch foraging water rate 24 sec	1.2	1.7	2.6	1.6	-1.1	1.1
Patch foraging water rate 6 sec	0.1	0.2	0.4	0.6	0.1	-0.1
Seeking ratio, delayed vs. immediate footshock	0.4	0.5	0.8	0.3	-0.8	0.9
Distance traveled before self-admin	0.7	0.8	1.5	-1.2	0.7	-0.6
Distance traveled after self-admin	0.9	1.0	1.2	1.1	-0.9	1.0
Extensor digitorum longus weight	1.4	5.3	7.8	2.8	-2.0	2.1
Bone: elastic displacement	1.2	1.4	1.9	1.4	-1.2	0.9
Bone: elastic work	0.3	0.4	0.7	-0.2	0.8	-0.8
Bone: endosteal estimation	1.3	2.7	2.9	-1.7	1.6	-1.7
Bone: endosteal perimeter	5.0	10.4	13.0	-3.6	2.9	-3.1
Epididymis fat weight	0.2	0.4	0.8	0.2	0.6	-0.9
Delta time in closed arm before/after self-admin	0.5	0.4	0.7	-0.8	0.5	-0.6
Delta time in open arm before/after self-admin	1.7	1.6	2.0	1.1	-1.3	1.4
Diff in mean of infusions in LGA sessions	1.3	1.5	2.0	-0.8	1.4	-1.3
Delay discount exponential model param	1.1	1.2	2.2	1.5	-0.8	0.8
Extinction: sum of active levers before priming	0.1	0.1	0.1	0.1	0.3	-0.3
Active lever presses in extinction session 6	0.1	0.1	0.2	0.4	0.1	-0.2
Bone: final force	1.4	2.3	3.0	-1.3	1.7	-1.4
Bone: final moment	1.6	2.6	3.4	-1.4	1.9	-1.5
Food consumed during 24 hour testing period	0.1	0.1	0.2	-0.4	-0.2	0.3
Glucose	0.0	0.0	0.0	0.1	-0.0	0.1
Heart weight	0.4	0.6	0.9	0.1	0.9	-0.9
Delay discount hyperbolic model param	0.9	1.0	1.9	1.4	-0.7	0.7
Intermittent access intake day 1-15 change	0.1	0.1	0.2	-0.5	-0.2	0.2
Intermittent access intake escalation	0.1	0.1	0.2	-0.3	-0.4	0.4
Intermittent access intake escalation 2	0.4	0.4	0.7	0.2	-0.8	0.8
Intermitt. access day 1 inactive lever presses	2.4	2.6	3.0	-1.7	1.5	-1.5
Intermitt. access day 15 inactive lever presses	0.5	0.5	0.7	0.5	-0.8	0.8
Intermitt. access escalation Index	0.9	0.8	1.4	-1.2	0.7	-0.7
Intermittent access day 1 total infusions	0.4	0.4	0.7	-0.0	0.8	-0.8
Intermittent access day 15 total infusions	0.0	0.0	0.0	-0.2	0.1	-0.1
Intermittent access terminal intake (last 3 days)	0.2	0.3	0.3	-0.5	0.5	-0.5
Intermittent access total infusions	0.3	0.3	0.5	-0.3	0.7	-0.7
Intermittent access day 1 locomotion	0.3	0.3	0.7	0.9	-0.3	0.3
Intermittent access day 15 total locomotion	0.1	0.1	0.2	-0.0	0.4	-0.4
Intermittent access total locomotion	0.2	0.2	0.5	0.7	-0.2	0.2
Intermittent access standard deviation	4.4	4.7	4.9	-2.1	2.2	-2.2
Left kidney weight	3.5	9.9	11.3	-2.8	3.4	-3.3
Right kidney weight	1.2	3.3	4.0	-1.5	2.0	-1.9
Cocaine induced anxiety	0.4	0.5	1.1	-1.0	0.4	-0.4
Post-drug Anxiety	0.1	0.2	0.2	-0.2	-0.5	0.5
Baseline Anxiety	0.0	0.0	0.1	0.3	-0.1	0.1
Tail length	0.2	0.7	1.0	0.3	-0.9	1.0
Length with tail	1.1	4.0	4.4	-2.1	2.0	-1.9
Length without tail	4.4	9.6	10.8	-2.7	3.3	-3.3
Times rat made contact with spout	0.4	0.5	0.7	0.4	-0.8	0.8
Lifetime Intake	0.5	0.6	0.8	-0.4	0.8	-0.9
Liver weight, left	3.1	5.0	5.3	-2.3	2.2	-2.3
Liver weight, right	0.8	1.4	1.6	-1.1	1.2	-1.3
Locomotor activity	0.0	0.0	0.0	0.1	-0.2	0.1
Locomotor testing distance	0.0	0.0	0.1	-0.3	0.1	-0.2
Locomotor testing rearing	1.2	1.9	2.6	1.0	-1.6	1.5
Locomotion in novel chamber	0.6	0.7	1.2	0.2	-1.0	1.1
Locomotion in novel chamber post-restriction	0.3	0.4	0.5	-0.7	0.6	-0.6
Fecal boli incidents, locomotor time 1	0.2	0.2	0.6	0.8	-0.2	0.2
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	0.5	-0.2	0.2
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.3	-0.6	-0.2	0.2
Bouts of movement, locomotor time 1	0.1	0.1	0.2	0.4	-0.1	0.1
Total resting periods, locomotor time 1	0.1	0.1	0.2	0.5	-0.3	0.3
Rest time, locomotor task time 1	0.3	0.4	0.5	-0.1	0.7	-0.7
Distance moved, locomotor task time 1	0.2	0.3	0.4	0.2	-0.6	0.6
Vertical activity count, locomotor time 1	2.0	2.1	2.4	1.2	-1.6	1.6
Time >=10cm from walls, locomotor time 2	0.5	0.6	0.7	0.5	-0.9	0.9
Bouts of movement, locomotor time 2	0.3	0.4	0.4	-0.5	0.7	-0.7
Total resting periods, locomotor time 2	0.4	0.4	0.5	-0.5	0.7	-0.7
Rest time, locomotor task time 2	1.0	1.2	1.5	-0.7	1.2	-1.2
Distance moved, locomotor task time 2	0.4	0.5	0.6	0.5	-0.8	0.8
Vertical activity count, locomotor time 2	0.4	0.5	0.6	0.8	-0.6	0.6
Light reinforcement 1	2.2	4.0	4.8	2.2	-2.0	1.9
Light reinforcement 2	0.2	0.2	0.3	0.5	-0.5	0.4
Bone: marrow area	1.3	2.8	3.0	-1.7	1.6	-1.7
Bone: maximum diameter	8.0	14.8	15.1	-3.8	3.9	-3.8
Bone: maximum force	1.7	2.9	3.8	-1.4	2.0	-1.8
Bone: maximum moment	1.9	3.3	4.2	-1.4	2.0	-1.9
Mean time between licks in bursts	0.0	0.1	0.1	-0.1	-0.2	0.4
Mean num. licks in bursts	0.4	0.5	0.6	0.8	-0.6	0.7
Cd content in liver	1.0	1.1	1.4	1.2	-0.9	0.9
Co content in liver	0.3	0.3	0.6	0.8	-0.3	0.5
Cu content in liver	0.1	0.1	0.2	0.0	0.4	-0.4
Fe content in liver	0.1	0.2	0.3	-0.6	0.4	-0.2
K content in liver	0.0	0.0	0.1	-0.2	-0.3	0.1
Mg content in liver	1.6	1.6	1.8	1.1	-1.3	1.4
Mn content in liver	0.8	0.9	1.3	-1.1	0.8	-0.9
Na content in liver	0.5	0.5	1.0	-1.0	0.5	-0.5
Rb content in liver	3.2	4.0	4.2	1.9	-2.0	2.1
Se content in liver	0.5	0.7	1.0	0.2	-1.0	1.0
Sr content in liver	0.1	0.1	0.2	-0.0	0.4	-0.4
Zn content in liver	1.9	2.1	2.7	-1.3	1.6	-1.4
Bone: minimum diameter	3.0	5.5	5.9	-2.4	2.3	-2.3
Time in familiar zone, hab. session 1	0.1	0.1	0.2	0.4	-0.3	0.2
Time in novel zone, hab. session 1	0.3	0.3	0.7	-0.8	0.4	-0.3
Total zone transitions, hab. session 1	2.2	3.1	3.4	1.6	-1.8	1.8
Total locomotion distance, hab. session 1	1.8	2.6	3.0	1.7	-1.5	1.5
Locomotion velocity, hab. session 1	2.4	3.4	4.2	2.1	-1.7	1.7
Time in familiar zone, hab. session 2	0.0	0.0	0.1	0.4	-0.0	-0.1
Time in novel zone, hab. session 2	0.4	0.4	0.7	-0.8	0.5	-0.4
Total zone transitions, hab. session 2	6.2	8.0	8.5	2.9	-2.8	2.7
Total locomotion distance, hab. session 2	5.7	7.6	9.8	3.1	-2.6	2.5
Locomotion velocity, hab. session 2	5.8	7.9	10.0	3.2	-2.7	2.5
Novel to familiar place preference ratio	2.0	2.0	2.2	1.5	-1.4	1.4
Novelty place preference	1.4	1.5	1.6	1.3	-1.2	1.2
Time in novel zone, NPP test	1.8	1.9	2.0	1.4	-1.3	1.4
Total zone transitions, NPP test	4.2	6.0	7.1	2.7	-2.3	2.3
Total locomotion distance, NPP test	7.6	10.5	14.2	3.8	-2.9	2.9
Locomotion velocity, NPP test	6.4	9.1	12.4	3.5	-2.7	2.7
Intraocular pressure	0.3	0.4	0.8	0.9	-0.4	0.4
Delta distance traveled before/after self-admin	2.4	2.5	3.5	1.9	-1.4	1.5
Delta ambulatory time before/after self-admin	2.3	2.5	3.4	1.9	-1.4	1.5
Parametrial fat weight	0.1	0.2	0.4	0.2	0.4	-0.6
Pavlov. Cond. lever latency	0.4	0.5	0.7	0.5	-0.8	0.7
Pavlov. Cond. magazine entry latency	2.4	3.1	3.7	-1.9	1.7	-1.6
Pavlov. Cond. change in total contacts	0.1	0.1	0.3	0.6	-0.1	0.3
Pavlov. Cond. index score	1.6	2.0	2.2	-1.3	1.5	-1.4
Pavlov. Cond. latency score	1.9	2.5	2.8	-1.5	1.7	-1.6
Pavlov. Cond. lever contacts	0.1	0.1	0.2	-0.0	0.5	-0.3
Pavlov. Cond. magazine entry number	3.5	4.4	4.6	2.1	-2.1	2.0
Pavlov. Cond. intertrial magazine entries	2.7	3.2	3.8	1.5	-1.9	1.9
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.3	1.4	-1.1	1.2	-1.1
Pavlov. Cond. response bias	1.6	1.9	2.1	-1.3	1.5	-1.3
Pavlov. Cond. lever latency	0.9	1.2	1.4	-1.0	1.1	-1.2
Pavlov. Cond. magazine entry latency	0.2	0.2	0.6	0.8	-0.1	0.2
Pavlov. Cond. change in total contacts	0.8	1.1	1.1	1.1	-1.0	1.0
Pavlov. Cond. index score	0.5	0.7	0.8	0.9	-0.7	0.9
Pavlov. Cond. latency score	0.3	0.3	0.4	0.6	-0.5	0.6
Pavlov. Cond. lever contacts	1.1	1.6	2.0	1.0	-1.3	1.4
Pavlov. Cond. magazine entry number	0.6	0.7	1.2	-1.1	0.6	-0.7
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.3	-0.2	-0.6	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	0.9	0.9	-0.8	0.9
Pavlov. Cond. response bias	0.8	1.0	1.1	1.1	-0.9	1.1
Time in closed arm before self-admin	0.1	0.1	0.1	0.4	-0.1	0.2
Time in closed arm after self-admin	2.7	2.8	3.2	-1.5	1.8	-1.7
Time in open arm before self-admin	0.5	0.5	0.6	-0.7	0.7	-0.8
Time in open arm after self-admin	0.6	0.7	0.9	0.7	-0.9	0.9
Bone: periosteal estimation	3.2	6.6	7.3	-2.3	2.7	-2.7
Bone: periosteal perimeter	6.8	11.3	11.8	-3.2	3.4	-3.4
Bone: post-yield work	0.2	0.3	0.4	0.6	-0.3	0.6
Progressive ratio test 1 active lever presses	0.0	0.0	0.0	0.1	-0.1	0.0
Progressive ratio test 1 breakpoint	0.0	0.0	0.0	0.1	0.1	-0.1
Progressive ratio test 1 inactive lever presses	0.2	0.2	0.4	-0.6	0.4	-0.4
Progressive ratio test 2 active lever presses	0.1	0.1	0.2	0.5	-0.0	-0.0
Progressive ratio test 2 breakpoint	0.1	0.1	0.3	0.5	-0.1	0.1
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.0	-0.0	0.1	-0.2
Incentive Sensitization - Responses	0.7	0.7	0.9	-0.5	0.9	-0.9
Incentive Sensitization - Breakpoint	0.9	0.9	1.1	-0.7	1.1	-1.1
Sum of active levers in priming session hrs 5-6	0.4	0.4	0.6	-0.5	0.8	-0.6
Progressive ratio	0.2	0.2	0.5	0.2	0.5	-0.7
Food seeking constrained by brief footshock	0.7	0.8	1.3	-0.6	0.9	-1.1
Seeking ratio, punishment vs. effort	0.1	0.2	0.4	-0.7	0.1	-0.0
Retroperitoneal fat weight	0.5	1.5	2.3	-0.8	1.3	-1.5
Reaction time number correct	3.6	5.1	6.1	2.1	-2.5	2.2
Reaction time mean minus median	0.5	0.7	0.9	-0.6	1.0	-0.9
Reaction time mean minus median AUC	0.9	1.1	1.2	-1.1	1.0	-1.1
Reaction time num false alarms	0.1	0.1	0.3	0.6	-0.3	0.2
Reaction time num false alarms AUC	0.2	0.3	0.6	0.8	-0.5	0.4
Reaction time trials correct on left	3.6	5.1	6.1	2.1	-2.5	2.2
Reaction time trials on left	3.5	5.0	5.9	2.0	-2.4	2.2
Reaction time mean	0.0	0.0	0.0	-0.2	0.2	-0.1
Reaction time mean AUC	0.0	0.0	0.0	0.1	0.0	0.0
Median of all reaction times	0.0	0.0	0.0	-0.1	-0.1	0.1
Reaction time omissions	0.7	1.0	1.1	-0.8	1.1	-1.1
Reaction time false alarm rate	0.3	0.4	0.6	-0.4	0.7	-0.8
Reaction time premature initiation rate	2.5	3.3	4.2	2.0	-1.6	1.8
Reaction time premature initiations	5.4	7.6	8.6	2.9	-2.7	2.7
Std. dev. reaction times	0.1	0.1	0.1	-0.1	0.4	-0.3
Reaction time trials completed	3.5	5.0	5.9	2.0	-2.4	2.2
Reaction time trials AUC	4.2	6.0	6.9	2.3	-2.6	2.5
Run reversals in cocaine runway, females	0.1	0.1	0.3	-0.0	0.2	-0.5
Run reversals in cocaine runway, males	0.3	0.3	0.7	0.3	0.4	-0.9
Latency to leave start box in cocaine runway	0.2	0.2	0.5	0.7	-0.2	0.2
Latency to leave start box in cocaine runway, F	0.5	0.5	0.7	0.8	-0.7	0.6
Latency to leave start box in cocaine runway, M	0.5	0.5	1.1	1.0	-0.4	0.5
Std. dev. time between licks in bursts	1.7	2.0	2.2	1.3	-1.5	1.5
Total sessions with >9 infusions	1.6	1.8	2.3	-0.9	1.5	-1.5
Short access day 1 total inactive lever presses	0.6	0.6	0.8	-0.7	0.8	-0.9
Short access day 10 total inactive lever presses	0.7	0.8	1.5	-1.2	0.7	-0.7
Short access day 1 total infusions	1.9	2.0	2.6	-1.1	1.6	-1.6
Short access day 10 total infusions	2.4	2.6	3.3	-1.2	1.8	-1.8
Short access total infusions	0.6	0.6	1.0	-0.3	0.9	-1.0
Short access day 1 locomotion	0.5	0.6	0.7	-0.5	0.8	-0.9
Short access day 10 total locomotion	0.5	0.6	0.8	-0.5	0.9	-0.8
Short access total locomotion	1.3	1.3	1.8	-0.6	1.3	-1.3
One hour access (0.3 mA shock)	0.1	0.1	0.2	0.4	-0.1	0.1
Compulsive drug intake	0.6	0.6	1.1	1.0	-0.6	0.6
One hour access (shock baseline)	0.0	0.0	0.1	-0.3	0.1	-0.1
Social response proportion	0.5	0.5	1.0	1.0	-0.5	0.5
Social responses	0.2	0.3	0.4	0.5	-0.6	0.6
Social time	0.6	0.8	1.5	1.2	-0.8	0.6
Soleus weight	0.8	2.5	3.3	1.8	-1.4	1.4
Bone: stiffness	1.6	2.5	3.2	-1.4	1.8	-1.5
Tibialis anterior weight	0.1	0.5	0.8	0.9	-0.5	0.6
Time to tail flick, vehicle, before self-admin	1.3	1.3	1.5	1.0	-1.2	1.2
Time to tail flick, vehicle, after self-admin	1.4	1.5	2.1	-0.7	1.5	-1.4
Time to tail flick, test, before self-admin	0.4	0.4	0.7	0.3	-0.8	0.7
Time to tail flick, test, after self-admin	0.7	0.7	0.9	-0.7	0.9	-0.9
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	0.6	-0.3	0.8	-0.8
Delta time to tail flick, test, before/after SA	1.7	1.6	1.9	-0.9	1.4	-1.4
Tibia length	12.0	33.9	34.7	-5.9	5.8	-5.7
Ambulatory time before self-admin	1.2	1.2	2.0	-1.4	0.9	-0.9
Ambulatory time after self-admin	0.1	0.2	0.2	0.5	-0.3	0.4
Bone: tissue strength	0.3	0.3	0.6	0.8	-0.3	0.3
Total heroin consumption	3.9	4.5	5.1	-1.9	2.3	-2.2
Bone: trabecular number	0.5	0.7	1.2	0.1	-1.0	1.1
Bone: trabecular spacing	0.4	0.5	0.8	-0.2	0.9	-0.9
Bone: trabecular thickness	0.6	0.7	1.0	0.4	-1.0	1.0
Bone: trabecular tissue density	0.2	0.4	0.6	0.2	0.8	-0.7
Water consumed over 24 hours	0.4	0.5	0.7	0.3	-0.8	0.8
Number of responses in last shaping day	2.2	2.3	2.5	-1.4	1.6	-1.6