Hub : Genes

LOC102547588

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	alternative TSS	XR_005492470.2	0.02	0.01	8.9e-03	0.01	0.01	0	0.01	1.8e-02	5.8e-02	9.8e-02	3.7e-02
2	NAcc	alternative polyA	XR_005492470.2	0.05	0.03	6.5e-05	0.03	0.03	0.03	0.02	1.1e-05	6.0e-05	4.6e-05	1.8e-04
3	Liver	gene expression	LOC102547588	0.11	0.05	1.7e-13	0.12	0.11	0.1	0.11	3.0e-13	2.9e-12	1.1e-11	3.6e-12
4	NAcc	alternative polyA	XR_005492473.2	0.03	0.02	7.0e-04	0.01	0.01	0.01	0.01	1.8e-02	3.7e-03	5.3e-03	1.4e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	1.2	2.1	4.1	0.6	2.0	1.3	-1.4
Area under the delay curve	1.5	1.7	2.4	1.6	1.2	1.3	-1.1
BMI with tail	0.3	0.9	3.1	0.7	1.8	0.1	-0.2
BMI without tail	0.4	1.3	2.0	-1.2	0.8	-1.4	1.0
Body weight	0.7	3.3	7.7	0.6	2.8	1.5	-1.7
Weight adjusted by age	0.2	0.3	0.9	-0.1	0.3	-0.6	0.9
Bone surface	0.7	1.3	3.6	-0.3	1.9	0.7	-1.0
Bone volume	0.8	1.4	3.2	0.4	1.8	1.1	-1.1
Breakpoint value in progressive ratio session	0.4	0.5	0.8	-0.8	-0.4	-0.9	0.7
Number of licking bursts	0.1	0.2	0.5	-0.2	0.7	0.3	-0.3
Context. condit. distance diff. score	1.5	1.8	4.0	-1.6	0.4	-2.0	0.7
Locomotion velocity, session 1	0.5	0.5	0.9	-0.7	0.9	-0.8	-0.0
Locomotion distance, session 1	0.6	0.8	1.6	-0.8	0.9	-1.3	0.4
Locomotion velocity, session 2	0.2	0.2	0.6	-0.1	-0.2	-0.4	0.8
Locomotion distance, session 2	0.5	0.7	1.9	-0.4	-0.1	-1.4	0.9
Locomotion velocity, session 3	1.8	2.0	3.6	-1.9	0.2	-1.9	1.0
Locomotion distance, session 3	4.8	5.2	9.4	-3.1	-0.1	-2.9	1.8
Stereotopy head waving bouts, day 3	0.2	0.2	0.4	0.4	-0.6	-0.2	0.4
Stereotopy head waving duration, day 3	0.4	0.5	1.2	1.1	-0.9	0.2	0.3
Locomotion velocity, session 7	2.8	3.1	6.8	-2.6	0.1	-2.2	0.9
Locomotion distance, session 7	5.8	7.4	12.3	-3.3	-0.8	-3.5	2.3
Stereotopy head waving bouts, day 7	0.2	0.3	0.7	0.8	0.3	0.1	-0.5
Stereotopy head waving duration, day 7	0.1	0.1	0.2	0.1	0.4	-0.3	-0.5
Locomotion velocity, session 8	2.0	2.5	4.7	-1.5	-0.6	-2.2	1.6
Locomotion distance, session 8	2.9	4.2	9.1	-2.0	-0.0	-3.0	1.9
Degree of sensitization distance	0.3	0.3	0.6	-0.5	-0.4	-0.8	0.5
Degree of sensitization stereotypy	0.1	0.1	0.2	0.2	0.3	-0.2	-0.4
Conditioned locomotion	1.6	1.9	2.7	1.6	1.3	1.3	-1.3
Cocaine response after cond. corrected	0.4	0.4	1.3	-0.4	1.2	-0.0	-0.5
Cocaine response after cond. not corrected	1.4	1.6	2.7	-1.6	1.6	-1.0	-0.3
Cocaine response before conditioning	1.7	2.1	4.2	-2.0	0.1	-1.8	0.9
Saline control response	0.1	0.2	0.4	-0.1	0.6	-0.6	-0.0
Bone: connectivity density	0.7	1.1	3.4	0.2	1.9	0.4	-0.9
Bone: cortical apparent density	0.1	0.1	0.2	0.4	-0.0	-0.3	-0.3
Bone: cortical area	0.2	0.3	1.0	0.3	1.0	0.5	-0.0
Bone: cortical porosity	0.2	0.2	0.8	-0.3	0.9	0.0	-0.1
Bone: cortical porosity	0.2	0.2	0.7	-0.0	0.8	0.3	-0.3
Bone: cortical thickness	0.7	1.2	2.3	1.5	1.2	0.9	-0.6
Bone: cortical thickness	0.1	0.2	0.4	-0.2	0.2	-0.3	0.7
Bone: cortical tissue density	0.1	0.1	0.2	0.3	-0.1	-0.4	-0.1
Condit. Reinf. active minus inactive responses	0.0	0.0	0.1	0.1	0.1	0.2	-0.3
Condit. Reinf. active-inactive response ratio	1.1	1.1	2.0	0.9	-0.0	1.4	-1.3
Condit. Reinf. active responses	0.6	0.7	1.4	-1.2	0.1	-1.0	0.6
Condit. Reinf. inactive responses	2.3	2.8	4.6	-1.9	0.2	-2.1	1.7
Incentive salience index mean	0.2	0.2	0.6	0.2	0.1	0.8	-0.4
Condit. Reinf. lever presses	0.2	0.3	1.1	0.4	-0.3	1.0	-0.0
Condit. Reinf. active minus inactive responses	4.4	5.7	9.9	-3.2	-0.5	-3.0	1.9
Condit. Reinf. active-inactive response ratio	3.7	4.2	6.9	-2.6	-0.9	-2.5	1.7
Condit. Reinf. active responses	2.3	3.2	5.5	-2.3	-0.4	-2.3	1.3
Condit. Reinf. inactive responses	0.2	0.3	0.5	0.5	0.5	0.5	-0.7
Condit. Reinf. lever presses	0.4	0.5	1.3	-1.1	0.1	-0.9	0.2
Condit. Reinf. lever reinforcers received	2.9	4.1	7.9	-2.8	-0.2	-2.6	1.3
Conditioned reinforcement - actives	0.4	0.7	1.0	0.9	1.0	0.8	-0.5
Conditioned reinforcement - inactives	0.1	0.2	0.5	0.4	-0.1	0.3	0.7
Conditioned locomotion	0.1	0.1	0.2	0.4	0.3	-0.0	0.1
Patch foraging indifference point 0 sec	0.3	0.5	1.2	-0.2	-1.1	0.8	0.1
Patch foraging indifference point AUC	0.2	0.3	0.8	0.4	-0.4	0.9	-0.5
Delay disc. indifference point, 0s delay	0.4	0.4	0.7	0.5	0.9	0.3	-0.7
Delay disc. indifference point, 16s delay	0.9	1.0	2.4	1.5	0.2	1.2	-0.6
Delay disc. indifference point, 2s delay	2.0	2.2	4.3	2.1	0.8	1.7	-1.0
Delay disc. indifference point, 24s delay	2.4	2.7	2.9	1.6	1.7	1.7	-1.6
Delay disc. indifference point, 4s delay	1.3	1.4	2.4	0.8	1.5	0.5	-1.5
Delay disc. indifference point, 8s delay	0.0	0.0	0.0	0.2	0.2	-0.1	0.1
Indifference point function ln k	0.5	0.9	1.6	0.7	1.3	0.7	-1.1
Indifference point function log k	0.5	0.9	1.6	0.7	1.3	0.7	-1.1
Patch foraging total patch changes 0 sec	0.3	0.5	1.3	-0.7	-1.1	0.4	0.4
Patch foraging total patch changes 12 sec	0.5	0.6	1.6	0.9	-0.4	1.2	-0.4
Patch foraging total patch changes 18 sec	0.3	0.4	0.8	-0.5	-0.8	0.9	-0.2
Patch foraging total patch changes 24 sec	1.3	2.1	3.4	-1.8	-1.8	-0.4	1.3
Patch foraging total patch changes 6 sec	0.4	0.5	1.4	-0.6	-1.2	0.1	0.6
Patch foraging time to switch 0 sec	0.2	0.5	0.8	0.4	-0.5	-0.9	0.9
Patch foraging water rate 0 sec	0.4	0.8	2.3	-1.5	-0.8	-0.0	0.4
Patch foraging water rate 12 sec	0.8	1.6	5.4	-2.3	-0.5	-0.7	0.7
Patch foraging water rate 18 sec	1.2	1.9	4.6	-2.2	-1.1	-0.8	1.1
Patch foraging water rate 24 sec	1.3	1.9	5.3	-2.3	-0.7	-0.8	1.0
Patch foraging water rate 6 sec	0.5	0.7	1.5	-0.8	0.3	1.2	-0.7
Seeking ratio, delayed vs. immediate footshock	0.2	0.3	0.5	-0.1	-0.7	-0.7	0.3
Distance traveled before self-admin	0.7	0.9	2.0	0.6	1.4	-0.4	-1.0
Distance traveled after self-admin	0.8	0.9	2.4	0.4	1.6	0.4	-1.0
Extensor digitorum longus weight	0.3	1.0	2.3	-1.5	1.2	0.3	0.4
Bone: elastic displacement	0.8	0.9	2.9	0.3	-1.7	-0.4	0.7
Bone: elastic work	1.3	1.7	4.7	1.0	-2.2	0.1	1.1
Bone: endosteal estimation	0.9	2.0	4.5	-2.1	-0.5	-1.2	1.3
Bone: endosteal perimeter	0.6	1.3	2.5	-1.6	-0.8	-0.8	1.1
Epididymis fat weight	1.2	4.2	7.0	1.4	2.6	1.9	-2.1
Delta time in closed arm before/after self-admin	0.3	0.3	0.6	-0.0	-0.6	-0.8	0.5
Delta time in open arm before/after self-admin	0.7	0.7	1.5	1.0	-0.5	1.2	-0.3
Diff in mean of infusions in LGA sessions	0.2	0.3	0.7	-0.9	-0.0	-0.5	0.3
Delay discount exponential model param	1.8	2.0	2.9	-1.7	-1.2	-1.4	1.3
Extinction: sum of active levers before priming	0.2	0.2	0.4	-0.5	-0.4	-0.6	0.3
Active lever presses in extinction session 6	2.5	2.5	4.8	-1.1	-1.6	-1.3	2.2
Bone: final force	0.2	0.3	0.7	-0.8	0.2	-0.2	0.7
Bone: final moment	0.4	0.6	1.4	-1.2	-0.1	-0.3	0.9
Food consumed during 24 hour testing period	0.1	0.2	0.7	0.2	-0.1	-0.2	0.8
Glucose	0.7	1.2	3.1	-1.1	-0.0	-1.8	0.5
Heart weight	0.2	0.4	0.8	-0.6	-0.0	-0.9	0.4
Delay discount hyperbolic model param	1.9	2.1	3.1	-1.8	-1.2	-1.5	1.4
Intermittent access intake day 1-15 change	0.1	0.1	0.3	-0.3	0.6	0.1	-0.1
Intermittent access intake escalation	0.1	0.2	0.5	-0.2	0.7	0.4	-0.4
Intermittent access intake escalation 2	0.2	0.2	0.4	-0.6	0.5	-0.5	0.1
Intermitt. access day 1 inactive lever presses	0.1	0.2	0.5	-0.3	-0.7	0.0	0.5
Intermitt. access day 15 inactive lever presses	0.5	1.1	2.4	-0.5	-0.5	-1.1	1.6
Intermitt. access escalation Index	5.5	7.8	10.7	-2.8	-1.7	-3.1	3.3
Intermittent access day 1 total infusions	0.2	0.4	0.7	-0.4	0.8	-0.8	0.1
Intermittent access day 15 total infusions	0.4	0.6	2.0	0.0	1.4	0.1	-0.5
Intermittent access terminal intake (last 3 days)	0.8	1.0	3.3	-0.0	1.8	-0.2	-0.9
Intermittent access total infusions	1.1	1.3	3.9	0.4	2.0	0.3	-1.1
Intermittent access day 1 locomotion	0.4	0.5	1.0	-0.5	0.7	-1.0	0.4
Intermittent access day 15 total locomotion	0.2	0.3	0.7	-0.6	-0.2	-0.8	0.6
Intermittent access total locomotion	0.2	0.3	0.9	-0.2	1.0	-0.4	-0.1
Intermittent access standard deviation	0.4	0.9	3.1	0.3	1.7	0.5	-0.6
Left kidney weight	0.6	2.6	4.3	1.2	2.1	1.4	-1.6
Right kidney weight	0.5	2.2	5.8	0.2	2.4	0.7	-1.6
Cocaine induced anxiety	0.0	0.1	0.1	0.3	0.1	-0.3	-0.3
Post-drug Anxiety	0.1	0.1	0.2	-0.2	-0.5	-0.3	0.0
Baseline Anxiety	1.4	1.6	1.9	-1.3	-1.3	-0.9	1.4
Tail length	0.4	1.7	5.7	-2.4	0.3	-0.9	0.3
Length with tail	0.5	2.4	3.5	-0.8	1.5	1.7	-1.9
Length without tail	2.2	7.1	12.6	1.7	1.9	3.6	-3.0
Times rat made contact with spout	0.4	0.4	1.0	-0.1	-1.0	-0.6	0.5
Lifetime Intake	1.6	1.9	5.6	0.4	2.4	0.1	-1.4
Liver weight, left	0.2	0.4	1.0	0.6	1.0	0.3	-0.2
Liver weight, right	0.9	1.7	2.7	0.6	1.6	1.4	-1.2
Locomotor activity	2.1	3.3	5.4	1.7	1.0	2.3	-2.0
Locomotor testing distance	5.5	9.8	12.9	3.2	2.1	3.6	-3.4
Locomotor testing rearing	0.9	1.9	3.1	0.6	1.5	1.3	-1.8
Locomotion in novel chamber	1.5	1.9	3.3	1.0	1.8	1.1	-1.5
Locomotion in novel chamber post-restriction	0.1	0.1	0.3	-0.5	0.2	-0.4	-0.0
Fecal boli incidents, locomotor time 1	0.9	1.3	2.0	-0.9	-1.0	-1.2	1.4
Change in fecal boli incidents, locomotor task	1.7	1.6	3.6	1.9	0.3	1.5	-0.9
Time >=10cm from walls, locomotor time 1	0.6	0.7	1.6	1.0	-1.2	0.2	0.5
Bouts of movement, locomotor time 1	2.3	2.6	3.5	-1.3	-1.8	-1.4	1.9
Total resting periods, locomotor time 1	2.1	2.3	3.3	-1.2	-1.8	-1.3	1.8
Rest time, locomotor task time 1	5.9	7.3	10.7	-1.9	-3.2	-2.1	3.3
Distance moved, locomotor task time 1	2.0	2.9	5.9	0.8	1.8	1.3	-2.4
Vertical activity count, locomotor time 1	1.0	2.4	4.9	-0.0	2.2	0.5	-2.1
Time >=10cm from walls, locomotor time 2	0.8	1.1	2.2	1.4	-0.6	1.5	-0.3
Bouts of movement, locomotor time 2	0.4	0.6	1.3	0.2	0.1	-1.0	1.2
Total resting periods, locomotor time 2	0.3	0.6	1.4	0.1	0.1	-0.9	1.2
Rest time, locomotor task time 2	1.1	1.4	2.1	-0.6	-1.1	-1.4	1.5
Distance moved, locomotor task time 2	0.6	0.7	1.7	-0.2	0.5	0.8	-1.3
Vertical activity count, locomotor time 2	1.0	1.3	2.3	0.2	1.5	0.9	-1.5
Light reinforcement 1	0.7	1.6	4.7	-0.4	-2.2	-0.6	1.1
Light reinforcement 2	0.3	0.4	1.6	-0.1	-1.3	0.4	0.0
Bone: marrow area	0.9	2.1	4.5	-2.1	-0.6	-1.3	1.4
Bone: maximum diameter	0.1	0.2	0.9	0.1	0.9	0.2	0.0
Bone: maximum force	0.2	0.3	0.7	-0.7	0.3	-0.2	0.8
Bone: maximum moment	0.3	0.6	1.2	-1.1	-0.1	-0.4	1.1
Mean time between licks in bursts	0.6	1.4	4.7	-2.2	0.8	-0.4	-0.0
Mean num. licks in bursts	0.6	0.9	1.9	-0.2	-1.4	-0.9	0.8
Cd content in liver	0.6	0.7	1.1	1.0	-0.8	1.0	-0.3
Co content in liver	0.8	0.9	2.1	-0.4	-1.5	-0.2	1.1
Cu content in liver	0.4	0.5	1.4	0.3	-1.2	0.2	0.6
Fe content in liver	0.1	0.2	0.4	-0.7	0.4	-0.3	0.0
K content in liver	4.8	4.6	7.2	2.7	0.9	2.7	-1.8
Mg content in liver	3.5	3.6	4.7	2.2	1.8	1.9	-1.7
Mn content in liver	0.9	0.9	2.4	1.5	0.1	1.0	-0.6
Na content in liver	0.3	0.3	0.7	0.1	-0.2	0.8	-0.7
Rb content in liver	0.5	0.6	1.6	1.3	0.8	0.4	-0.1
Se content in liver	0.3	0.4	0.8	0.5	0.4	0.9	-0.5
Sr content in liver	1.2	1.0	3.1	0.7	-1.8	0.3	0.5
Zn content in liver	2.8	3.1	4.5	1.8	1.2	2.1	-1.8
Bone: minimum diameter	0.3	0.6	1.8	-1.4	-0.1	-0.5	0.5
Time in familiar zone, hab. session 1	0.3	0.3	1.2	1.1	0.3	-0.1	-0.1
Time in novel zone, hab. session 1	2.3	2.3	3.8	-2.0	-0.7	-1.8	1.3
Total zone transitions, hab. session 1	0.3	0.4	1.2	1.1	0.6	-0.3	0.2
Total locomotion distance, hab. session 1	0.5	0.8	1.7	0.0	-0.1	-1.2	1.3
Locomotion velocity, hab. session 1	0.4	0.5	1.4	0.1	-0.2	-0.8	1.2
Time in familiar zone, hab. session 2	0.5	0.6	1.2	0.5	1.1	0.7	-0.7
Time in novel zone, hab. session 2	3.3	3.4	4.4	-1.7	-1.6	-2.1	1.9
Total zone transitions, hab. session 2	0.1	0.1	0.3	-0.1	0.6	-0.4	0.3
Total locomotion distance, hab. session 2	0.8	1.1	2.5	-0.5	-0.2	-1.3	1.6
Locomotion velocity, hab. session 2	0.8	1.1	2.4	-0.5	-0.2	-1.3	1.6
Novel to familiar place preference ratio	9.2	10.1	12.2	-2.9	-2.9	-3.5	3.4
Novelty place preference	9.3	10.1	11.8	-2.8	-3.0	-3.4	3.4
Time in novel zone, NPP test	9.0	9.7	11.4	-2.7	-3.0	-3.4	3.3
Total zone transitions, NPP test	0.4	0.6	1.1	-0.6	0.1	-1.1	0.9
Total locomotion distance, NPP test	2.3	3.1	5.9	-1.2	-0.9	-2.1	2.4
Locomotion velocity, NPP test	1.9	2.7	5.0	-1.3	-0.8	-1.9	2.2
Intraocular pressure	0.7	1.0	3.3	-0.4	1.8	-0.6	-0.3
Delta distance traveled before/after self-admin	0.1	0.1	0.3	-0.0	-0.5	0.5	0.3
Delta ambulatory time before/after self-admin	0.3	0.4	1.1	0.7	0.2	1.0	-0.3
Parametrial fat weight	6.5	15.2	27.5	2.1	5.2	3.3	-4.3
Pavlov. Cond. lever latency	0.4	0.5	1.0	-0.7	1.0	-0.7	-0.4
Pavlov. Cond. magazine entry latency	0.4	0.5	0.9	0.9	-0.3	0.9	-0.3
Pavlov. Cond. change in total contacts	0.5	0.5	1.4	0.6	0.2	1.2	-0.6
Pavlov. Cond. index score	0.3	0.4	0.8	0.6	-0.9	0.6	0.3
Pavlov. Cond. latency score	0.3	0.4	0.7	0.8	-0.9	0.6	0.3
Pavlov. Cond. lever contacts	0.4	0.5	1.0	0.6	-1.0	0.7	0.3
Pavlov. Cond. magazine entry number	0.3	0.4	0.7	-0.8	0.4	-0.8	0.1
Pavlov. Cond. intertrial magazine entries	1.8	2.1	2.8	-1.6	-0.7	-1.7	1.7
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.4	0.5	-0.5	0.7	0.0
Pavlov. Cond. response bias	0.3	0.4	0.9	0.7	-0.4	1.0	-0.1
Pavlov. Cond. lever latency	0.8	1.0	2.3	1.5	0.1	1.2	-0.5
Pavlov. Cond. magazine entry latency	0.7	0.9	1.7	-1.0	-0.2	-1.3	0.9
Pavlov. Cond. change in total contacts	0.6	1.0	1.7	-1.3	-0.6	-1.2	0.7
Pavlov. Cond. index score	0.7	0.9	1.7	-1.2	-0.1	-1.3	0.6
Pavlov. Cond. latency score	0.7	1.0	1.8	-1.3	0.0	-1.3	0.5
Pavlov. Cond. lever contacts	0.4	0.5	1.1	-1.0	0.1	-1.0	0.1
Pavlov. Cond. magazine entry number	1.1	1.4	2.9	1.1	0.3	1.7	-1.1
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.9	0.8	-0.9	0.4	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.7	1.0	1.8	-1.2	-0.1	-1.3	0.7
Pavlov. Cond. response bias	0.6	0.8	1.5	-1.1	-0.3	-1.2	0.6
Time in closed arm before self-admin	0.2	0.2	0.5	-0.0	-0.5	0.7	-0.3
Time in closed arm after self-admin	0.4	0.4	1.4	-0.4	-1.2	-0.0	0.1
Time in open arm before self-admin	0.8	0.9	3.1	-0.2	1.7	-0.6	-0.3
Time in open arm after self-admin	0.1	0.1	0.3	0.5	0.3	0.4	0.1
Bone: periosteal estimation	0.3	0.6	1.3	-1.1	0.3	-0.5	0.8
Bone: periosteal perimeter	0.2	0.3	0.6	-0.7	0.2	-0.5	0.7
Bone: post-yield work	0.2	0.2	0.8	-0.2	0.9	0.4	-0.1
Progressive ratio test 1 active lever presses	1.0	1.2	4.1	0.1	2.0	-0.1	-0.9
Progressive ratio test 1 breakpoint	1.1	1.3	4.4	0.2	2.1	-0.0	-0.9
Progressive ratio test 1 inactive lever presses	0.6	0.9	3.0	0.4	1.7	0.1	-0.5
Progressive ratio test 2 active lever presses	1.4	1.6	3.9	0.4	2.0	0.7	-1.4
Progressive ratio test 2 breakpoint	1.6	1.8	4.2	0.4	2.1	0.7	-1.5
Progressive ratio test 2 inactive lever presses	0.4	0.7	2.2	0.4	1.5	0.3	-0.7
Incentive Sensitization - Responses	0.8	1.1	1.8	0.4	1.3	1.0	-1.2
Incentive Sensitization - Breakpoint	0.8	1.0	1.8	0.3	1.3	0.9	-1.1
Sum of active levers in priming session hrs 5-6	1.2	1.1	2.2	0.0	-1.5	-0.0	1.5
Progressive ratio	0.2	0.2	0.8	-0.0	-0.4	0.9	-0.1
Food seeking constrained by brief footshock	1.1	1.3	3.2	1.8	-1.0	1.0	-0.0
Seeking ratio, punishment vs. effort	0.3	0.5	1.5	1.2	-0.4	-0.2	0.2
Retroperitoneal fat weight	1.2	5.0	13.3	0.2	3.6	1.5	-2.1
Reaction time number correct	3.0	5.7	9.9	-3.1	-1.3	-2.5	2.3
Reaction time mean minus median	0.4	1.0	3.1	-0.4	0.4	-1.7	0.6
Reaction time mean minus median AUC	0.6	1.5	4.2	-0.8	0.1	-2.1	1.1
Reaction time num false alarms	0.9	1.3	1.9	0.7	1.4	1.1	-1.3
Reaction time num false alarms AUC	0.8	1.2	2.0	0.6	1.4	0.8	-1.4
Reaction time trials correct on left	3.0	5.7	9.9	-3.1	-1.3	-2.5	2.3
Reaction time trials on left	2.9	5.5	9.6	-3.1	-1.2	-2.5	2.2
Reaction time mean	3.2	5.1	11.1	3.3	1.8	1.5	-2.0
Reaction time mean AUC	2.3	3.6	9.4	3.1	1.3	1.1	-1.5
Median of all reaction times	5.8	8.2	15.9	4.0	2.0	2.5	-2.6
Reaction time omissions	1.7	2.5	4.1	1.2	2.0	0.7	-2.0
Reaction time false alarm rate	2.4	3.3	4.3	1.8	1.7	1.7	-2.1
Reaction time premature initiation rate	0.9	1.3	3.1	0.4	1.7	0.7	-1.3
Reaction time premature initiations	0.3	0.6	1.3	-1.1	0.8	-0.6	0.1
Std. dev. reaction times	0.6	1.1	2.3	1.5	1.3	-0.3	-0.7
Reaction time trials completed	2.9	5.5	9.6	-3.1	-1.2	-2.5	2.2
Reaction time trials AUC	2.9	5.5	9.6	-3.1	-1.2	-2.5	2.2
Run reversals in cocaine runway, females	0.5	0.5	1.4	-1.2	0.1	-0.7	0.3
Run reversals in cocaine runway, males	0.0	0.0	0.1	-0.3	0.1	-0.0	0.2
Latency to leave start box in cocaine runway	0.6	0.7	1.7	0.2	-1.3	1.0	-0.1
Latency to leave start box in cocaine runway, F	0.4	0.5	1.1	0.4	-0.7	1.0	-0.5
Latency to leave start box in cocaine runway, M	0.6	0.6	2.0	-0.1	-1.4	0.4	0.4
Std. dev. time between licks in bursts	1.6	2.2	5.7	-2.4	0.9	-1.2	0.7
Total sessions with >9 infusions	2.0	2.5	7.0	0.3	2.6	-0.4	-1.6
Short access day 1 total inactive lever presses	0.3	0.4	0.8	0.2	0.9	0.5	-0.8
Short access day 10 total inactive lever presses	0.4	0.9	2.0	0.1	-1.4	-0.4	1.3
Short access day 1 total infusions	2.6	3.4	9.0	0.4	3.0	0.2	-2.1
Short access day 10 total infusions	2.1	2.6	8.0	0.3	2.8	-0.0	-1.6
Short access total infusions	2.9	3.7	8.5	1.1	2.9	0.5	-2.2
Short access day 1 locomotion	1.3	1.6	4.4	0.4	2.1	-0.3	-1.3
Short access day 10 total locomotion	0.8	1.5	4.6	-0.1	2.2	-0.1	-1.1
Short access total locomotion	2.0	2.4	6.3	0.6	2.5	-0.1	-1.7
One hour access (0.3 mA shock)	1.0	1.1	2.0	-1.3	1.4	-1.0	0.1
Compulsive drug intake	0.6	0.8	1.6	-1.3	-0.5	-0.7	0.8
One hour access (shock baseline)	0.8	1.2	4.0	-0.0	2.0	-0.1	-0.9
Social response proportion	0.4	0.5	1.2	1.1	0.3	0.7	-0.5
Social responses	0.7	0.8	1.9	1.1	0.0	1.4	-0.5
Social time	2.1	2.8	4.0	1.3	1.4	2.0	-1.9
Soleus weight	0.4	1.1	1.9	0.8	-1.4	0.5	1.3
Bone: stiffness	1.0	1.6	5.3	-0.3	2.3	0.5	-0.9
Tibialis anterior weight	0.1	0.4	1.2	-1.1	0.1	0.5	0.2
Time to tail flick, vehicle, before self-admin	1.2	1.2	2.2	1.5	1.2	0.9	-0.7
Time to tail flick, vehicle, after self-admin	0.2	0.3	0.5	0.0	0.5	0.7	-0.6
Time to tail flick, test, before self-admin	1.8	1.9	3.1	-1.8	-1.4	-1.1	1.0
Time to tail flick, test, after self-admin	0.6	0.7	1.4	0.3	-1.2	0.7	0.8
Delta time to tail flick, vehicle, before/after SA	0.8	0.8	2.1	-1.4	-0.3	-0.9	0.4
Delta time to tail flick, test, before/after SA	3.7	3.8	6.4	2.5	1.1	2.3	-1.4
Tibia length	0.7	1.8	2.4	0.3	1.5	1.5	-1.5
Ambulatory time before self-admin	0.4	0.7	1.8	-0.4	0.9	-1.3	0.0
Ambulatory time after self-admin	1.2	1.5	2.3	1.4	1.5	0.7	-1.0
Bone: tissue strength	0.1	0.1	0.1	0.3	0.1	0.3	0.1
Total heroin consumption	5.6	6.5	8.0	-2.3	-2.3	-2.8	2.8
Bone: trabecular number	0.5	0.8	1.9	0.3	1.4	0.6	-0.8
Bone: trabecular spacing	0.4	0.6	0.9	-0.1	-0.9	-0.8	0.8
Bone: trabecular thickness	0.9	1.1	2.3	0.9	0.5	1.5	-1.0
Bone: trabecular tissue density	0.7	1.0	1.6	-0.9	-1.3	-0.8	1.0
Water consumed over 24 hours	0.1	0.1	0.2	-0.3	0.0	-0.4	0.5
Number of responses in last shaping day	0.1	0.1	0.2	0.5	0.5	0.0	-0.1