Hub : Genes

LOC102546827

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression LOC102546827 0.04 0.03 1.0e-03 0.02 0.02 0.02 0.02 4.1e-03 5.2e-03 5.0e-03 6.0e-03
2 OFC gene expression LOC102546827 0.44 0.16 9.2e-07 0.18 0.24 0.2 0.2 5.5e-05 2.5e-06 1.6e-05 1.3e-05
3 BLA gene expression LOC102546827 0.41 0.12 1.7e-16 0.26 0.27 0.28 0.27 3.0e-14 1.3e-14 2.7e-15 6.8e-15
4 Brain mRNA stability LOC102546827 0.31 0.12 0.0e+00 0.24 0.23 0.24 0.24 2.8e-22 4.6e-21 3.0e-22 1.4e-22
5 LHb gene expression LOC102546827 0.65 0.12 6.1e-15 0.47 0.41 0.44 0.45 8.1e-13 9.9e-11 1.2e-11 4.8e-12
6 Brain gene expression LOC102546827 0.48 0.11 0.0e+00 0.43 0.42 0.43 0.44 1.5e-43 3.8e-42 1.5e-43 4.8e-45
7 pVTA gene expression LOC102546827 0.68 0.1 0.0e+00 0.47 0.49 0.5 0.52 6.5e-23 6.6e-24 6.7e-25 7.3e-26
8 Brain isoform ratio XR_005491678.1 0.06 0.04 2.9e-04 0.04 0.04 0.03 0.04 2.2e-04 1.4e-04 3.4e-04 2.8e-04
9 IL gene expression LOC102546827 0.34 0.12 3.8e-07 0.24 0.27 0.26 0.28 2.2e-06 3.7e-07 4.6e-07 1.4e-07
10 Brain alternative TSS XR_005491678.1 0.04 0.03 3.9e-03 0.01 0.02 0.02 0.01 1.5e-02 2.6e-03 3.5e-03 1.2e-02
11 RMTg gene expression LOC102546827 0.27 0.11 6.5e-05 0.11 0.12 0.11 0.1 8.8e-04 5.3e-04 8.0e-04 1.3e-03
12 Brain alternative TSS XR_005491679.1 0.04 0.03 6.8e-03 0.02 0.02 0.02 0.02 4.8e-03 3.9e-03 5.0e-03 9.9e-03
13 PL gene expression LOC102546827 0.39 0.1 0.0e+00 0.34 0.36 0.37 0.37 6.2e-39 7.4e-41 3.2e-43 4.5e-43
14 NAcc gene expression LOC102546827 0.43 0.14 0.0e+00 0.26 0.26 0.27 0.26 4.6e-30 9.1e-30 3.0e-31 1.9e-30

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density4.98.223.34.83.8-3.33.2-2.72.82.71.13.01.52.5-1.4-2.4-2.5
Area under the delay curve0.20.20.7-0.8-0.70.6-0.50.5-0.4-0.40.3-0.10.2-0.3-0.20.2-0.4
BMI with tail1.54.813.23.62.8-2.72.1-2.12.42.21.22.11.52.2-1.5-1.7-1.3
BMI without tail0.40.93.30.2-0.10.3-0.70.6-0.6-0.5-1.8-0.7-1.5-0.51.51.01.1
Body weight3.012.658.17.65.4-4.83.3-3.33.33.5-0.62.20.12.7-0.1-1.9-2.3
Weight adjusted by age0.40.43.01.10.1-0.3-0.20.0-0.3-0.1-0.8-0.3-0.6-0.50.60.3-1.7
Bone surface3.96.922.74.83.6-3.12.8-2.42.52.50.72.81.12.2-1.1-2.0-2.2
Bone volume5.910.123.24.84.1-3.63.5-3.03.23.11.83.52.13.0-2.1-2.8-2.7
Breakpoint value in progressive ratio session0.20.31.8-1.0-0.1-0.10.1-0.3-0.10.0-0.5-0.1-0.3-0.10.3-0.2-1.3
Number of licking bursts3.84.49.30.6-1.61.7-2.02.1-2.0-2.2-1.9-2.3-2.1-2.32.12.53.0
Context. condit. distance diff. score2.32.85.91.42.4-1.91.9-1.91.71.80.41.60.61.7-0.6-1.6-2.3
Locomotion velocity, session 10.40.51.3-1.2-1.00.3-0.80.6-0.5-0.2-0.6-1.0-0.5-0.80.40.4-0.6
Locomotion distance, session 10.10.20.7-0.6-0.80.2-0.60.7-0.3-0.1-0.0-0.40.1-0.5-0.20.2-0.2
Locomotion velocity, session 22.32.75.5-1.0-1.91.4-2.02.3-1.7-1.7-1.4-1.8-1.3-1.91.31.80.9
Locomotion distance, session 22.02.75.5-0.5-2.11.5-2.02.3-1.9-1.8-1.3-1.4-1.1-2.01.11.81.3
Locomotion velocity, session 30.50.61.30.81.1-0.70.7-0.50.70.70.51.00.60.7-0.6-0.7-1.0
Locomotion distance, session 30.10.10.60.20.5-0.30.2-0.20.30.20.10.80.20.3-0.2-0.4-0.7
Stereotopy head waving bouts, day 30.20.21.20.70.1-0.10.1-0.2-0.00.0-1.1-0.0-0.9-0.20.90.20.4
Stereotopy head waving duration, day 30.00.00.20.0-0.0-0.20.3-0.50.10.20.10.00.10.1-0.1-0.2-0.2
Locomotion velocity, session 70.10.10.30.0-0.10.20.3-0.4-0.0-0.10.6-0.20.4-0.1-0.4-0.3-0.6
Locomotion distance, session 70.00.10.4-0.0-0.00.30.3-0.6-0.1-0.30.20.20.1-0.0-0.1-0.3-0.1
Stereotopy head waving bouts, day 71.01.15.1-2.3-1.21.2-1.21.0-1.2-1.0-0.6-0.8-0.6-0.80.60.6-0.4
Stereotopy head waving duration, day 71.21.43.9-2.0-1.51.2-1.51.4-1.4-1.2-0.6-1.3-0.7-1.20.71.0-0.1
Locomotion velocity, session 80.50.61.1-1.0-0.70.4-0.80.7-0.7-0.3-0.9-0.7-0.8-0.70.70.5-1.0
Locomotion distance, session 80.30.41.71.30.9-0.90.5-0.20.50.6-0.40.5-0.10.30.1-0.4-1.1
Degree of sensitization distance0.60.61.6-0.9-1.31.0-0.70.5-0.9-0.9-0.2-1.0-0.4-0.90.40.70.7
Degree of sensitization stereotypy0.91.05.0-2.2-1.01.1-1.21.0-1.2-1.0-0.4-0.7-0.4-0.70.40.6-0.6
Conditioned locomotion1.82.14.31.01.2-2.11.5-1.41.61.70.91.81.31.6-1.3-1.6-0.5
Cocaine response after cond. corrected0.70.81.6-0.20.7-0.60.8-0.81.01.01.01.31.01.2-1.0-1.0-0.2
Cocaine response after cond. not corrected1.61.82.9-0.21.2-1.01.3-1.31.51.41.31.71.41.7-1.4-1.5-0.9
Cocaine response before conditioning0.80.93.10.31.0-1.01.0-1.20.80.90.50.70.70.9-0.7-1.1-1.8
Saline control response2.12.77.10.2-1.00.9-1.31.2-1.5-1.3-2.7-2.1-2.4-1.92.41.60.6
Bone: connectivity density3.45.321.54.63.2-2.82.4-2.12.02.2-0.12.10.41.6-0.4-1.5-2.5
Bone: cortical apparent density0.10.10.50.10.0-0.20.4-0.10.30.20.70.10.50.2-0.5-0.3-0.1
Bone: cortical area1.72.69.53.12.1-1.91.9-1.51.71.50.71.40.81.4-0.8-1.3-1.0
Bone: cortical porosity0.80.81.3-1.1-1.01.1-1.00.9-0.9-1.1-0.9-0.8-0.8-0.80.80.80.7
Bone: cortical porosity0.91.01.7-1.3-1.21.2-1.11.0-1.0-1.2-0.8-0.9-0.8-0.90.80.90.6
Bone: cortical thickness1.42.38.12.82.0-1.71.9-1.41.71.30.61.40.71.4-0.7-1.2-0.4
Bone: cortical thickness0.20.20.80.3-0.00.20.20.1-0.3-0.2-0.9-0.5-0.9-0.40.90.20.4
Bone: cortical tissue density0.10.10.5-0.00.0-0.20.4-0.10.30.10.70.10.50.2-0.5-0.3-0.1
Condit. Reinf. active minus inactive responses0.91.01.71.30.7-1.20.9-0.61.00.91.20.71.30.7-1.3-0.7-0.7
Condit. Reinf. active-inactive response ratio0.80.91.61.10.8-1.01.0-0.80.90.81.30.81.20.8-1.2-0.8-0.5
Condit. Reinf. active responses0.10.20.40.20.2-0.60.20.20.40.50.50.10.60.3-0.6-0.2-0.4
Condit. Reinf. inactive responses0.50.62.2-1.5-0.80.6-1.01.1-0.6-0.5-0.5-0.8-0.4-0.60.40.70.2
Incentive salience index mean1.01.21.71.10.8-1.31.0-0.81.21.21.20.91.31.0-1.3-1.0-0.6
Condit. Reinf. lever presses0.71.01.60.30.7-1.01.0-1.11.31.30.91.01.01.2-1.0-1.1-0.5
Condit. Reinf. active minus inactive responses1.31.63.0-0.1-1.01.1-1.00.9-1.3-1.0-1.6-1.7-1.6-1.41.61.21.1
Condit. Reinf. active-inactive response ratio1.92.04.4-0.3-1.51.3-1.21.0-1.6-1.3-1.5-2.1-1.6-1.71.61.30.7
Condit. Reinf. active responses0.40.51.60.1-0.30.4-0.60.4-0.6-0.5-1.3-1.0-1.1-0.81.10.70.4
Condit. Reinf. inactive responses0.20.30.80.20.9-0.60.5-0.50.60.5-0.00.70.10.6-0.1-0.5-0.7
Condit. Reinf. lever presses1.21.72.51.51.5-1.51.5-1.61.41.40.71.20.91.2-0.9-1.4-0.7
Condit. Reinf. lever reinforcers received0.40.61.30.0-0.40.5-0.60.5-0.8-0.7-1.2-1.1-1.1-0.91.10.70.3
Conditioned reinforcement - actives1.11.13.60.1-0.00.5-0.80.6-0.9-0.8-1.9-1.0-1.7-0.81.71.00.4
Conditioned reinforcement - inactives0.40.51.5-0.2-0.01.1-0.30.7-0.6-1.0-0.7-0.2-0.8-0.40.90.61.2
Conditioned locomotion0.81.03.6-0.4-0.30.4-1.00.8-1.0-0.6-1.9-0.8-1.6-0.81.60.90.1
Patch foraging indifference point 0 sec2.13.44.92.02.2-2.12.0-2.22.01.81.41.71.61.8-1.6-1.9-0.8
Patch foraging indifference point AUC0.30.31.81.30.5-0.40.3-0.20.40.3-0.60.5-0.40.10.4-0.00.8
Delay disc. indifference point, 0s delay0.20.21.30.30.2-0.10.3-0.20.10.20.60.20.50.0-0.5-0.3-1.2
Delay disc. indifference point, 16s delay0.30.31.4-1.1-0.20.7-0.30.4-0.3-0.20.2-0.00.10.0-0.10.1-1.2
Delay disc. indifference point, 2s delay0.40.41.2-0.9-0.3-0.10.3-0.30.30.31.10.71.00.3-1.0-0.7-0.6
Delay disc. indifference point, 24s delay0.70.71.6-1.1-1.01.3-1.11.0-1.0-1.0-0.2-0.6-0.3-0.80.30.80.3
Delay disc. indifference point, 4s delay0.50.51.3-0.50.0-0.30.3-0.40.60.61.01.01.00.6-1.0-0.8-1.1
Delay disc. indifference point, 8s delay0.10.10.4-0.1-0.60.3-0.20.3-0.3-0.40.20.00.1-0.2-0.10.30.7
Indifference point function ln k0.30.51.6-0.5-0.50.6-0.60.6-0.8-0.8-0.5-1.3-0.7-0.80.70.80.0
Indifference point function log k0.30.51.6-0.5-0.50.6-0.60.6-0.8-0.8-0.5-1.3-0.7-0.80.70.80.0
Patch foraging total patch changes 0 sec2.33.75.22.02.3-2.32.1-2.32.21.91.41.81.61.9-1.6-2.0-0.9
Patch foraging total patch changes 12 sec4.35.58.42.92.7-2.62.5-2.52.82.51.62.61.92.4-1.9-2.3-0.8
Patch foraging total patch changes 18 sec1.21.52.61.31.5-1.31.3-1.31.61.20.71.60.91.4-0.9-1.3-0.2
Patch foraging total patch changes 24 sec1.82.23.81.51.6-1.91.5-1.71.71.61.01.61.21.5-1.2-1.5-0.5
Patch foraging total patch changes 6 sec1.42.13.41.51.7-1.71.6-1.81.81.60.71.51.01.5-1.0-1.5-0.0
Patch foraging time to switch 0 sec0.71.02.5-1.2-0.0-0.20.6-0.90.60.61.60.81.40.9-1.4-1.1-1.3
Patch foraging water rate 0 sec0.50.74.52.11.0-0.70.4-0.10.2-0.0-1.2-0.1-1.0-0.11.00.30.6
Patch foraging water rate 12 sec0.91.42.10.9-0.70.8-1.21.4-1.2-1.4-1.3-1.0-1.2-1.31.21.41.3
Patch foraging water rate 18 sec1.11.52.6-0.9-1.40.9-1.21.4-1.2-1.2-1.2-1.6-1.2-1.31.21.31.1
Patch foraging water rate 24 sec1.11.64.00.6-0.70.3-1.01.0-1.2-1.1-2.0-1.4-1.8-1.31.81.31.1
Patch foraging water rate 6 sec0.20.32.31.50.7-0.60.10.10.10.0-0.20.2-0.10.00.10.2-0.5
Seeking ratio, delayed vs. immediate footshock0.20.22.0-1.4-0.60.20.1-0.20.00.00.5-0.20.40.1-0.4-0.30.2
Distance traveled before self-admin0.10.10.5-0.20.00.20.3-0.20.3-0.00.70.10.50.2-0.5-0.30.2
Distance traveled after self-admin0.00.00.30.60.2-0.00.10.00.2-0.00.10.00.10.1-0.1-0.00.3
Extensor digitorum longus weight0.62.28.02.72.8-1.71.3-1.41.21.4-0.71.4-0.51.40.5-0.7-0.8
Bone: elastic displacement1.71.92.7-1.1-1.11.5-1.41.6-1.2-1.4-1.6-0.9-1.5-1.21.51.31.5
Bone: elastic work0.50.73.61.90.6-0.20.00.3-0.0-0.2-1.40.2-1.2-0.31.20.50.8
Bone: endosteal estimation0.20.51.31.00.00.1-0.70.5-0.7-0.3-1.1-0.4-1.0-0.71.00.90.5
Bone: endosteal perimeter0.40.73.81.91.2-1.10.7-0.80.60.9-0.10.70.00.6-0.0-0.4-0.5
Epididymis fat weight1.53.55.02.22.2-2.11.8-1.81.91.81.81.91.81.9-1.8-1.6-1.4
Delta time in closed arm before/after self-admin0.80.81.40.2-0.71.1-0.70.7-0.9-1.2-0.8-1.0-0.9-1.01.01.11.0
Delta time in open arm before/after self-admin1.00.94.0-2.0-0.0-0.30.2-0.20.40.71.21.11.30.8-1.3-1.0-0.8
Diff in mean of infusions in LGA sessions0.10.11.0-0.70.10.40.1-0.0-0.2-0.0-0.20.0-0.20.10.2-0.1-1.0
Delay discount exponential model param0.20.30.91.00.8-0.70.6-0.60.50.5-0.30.1-0.10.30.1-0.30.3
Extinction: sum of active levers before priming1.31.32.80.20.8-1.01.3-1.21.00.91.30.91.31.0-1.3-1.2-1.7
Active lever presses in extinction session 60.90.91.91.31.4-0.91.1-1.01.00.70.71.10.70.9-0.7-0.8-0.7
Bone: final force0.40.65.22.30.8-0.80.5-0.50.30.4-0.7-0.2-0.6-0.00.60.1-0.4
Bone: final moment0.30.54.52.10.6-0.70.3-0.30.20.4-0.7-0.3-0.6-0.10.60.2-0.1
Food consumed during 24 hour testing period0.81.01.6-1.1-1.01.0-0.90.6-0.9-0.8-1.2-1.0-1.2-0.81.20.81.1
Glucose0.10.10.2-0.1-0.20.3-0.20.4-0.2-0.40.4-0.40.3-0.2-0.30.2-0.1
Heart weight1.72.43.2-0.3-1.31.3-1.41.7-1.6-1.6-1.5-1.7-1.6-1.71.61.81.8
Delay discount hyperbolic model param0.20.20.91.00.7-0.60.5-0.50.40.4-0.4-0.1-0.30.20.3-0.10.4
Intermittent access intake day 1-15 change0.30.31.00.4-0.10.4-0.50.5-0.4-0.4-1.0-0.5-0.9-0.40.90.5-0.1
Intermittent access intake escalation0.40.41.10.4-0.10.4-0.50.5-0.5-0.5-1.1-0.6-0.9-0.50.90.6-0.1
Intermittent access intake escalation 20.00.00.10.3-0.2-0.1-0.20.1-0.1-0.1-0.3-0.2-0.2-0.20.20.20.2
Intermitt. access day 1 inactive lever presses1.41.52.3-0.5-0.61.4-1.31.5-1.3-1.5-1.2-0.6-1.3-1.11.31.51.3
Intermitt. access day 15 inactive lever presses0.40.51.0-0.50.6-0.00.7-0.60.70.51.00.60.80.9-0.8-0.8-0.0
Intermitt. access escalation Index0.20.20.3-0.0-0.40.5-0.40.4-0.4-0.5-0.3-0.3-0.4-0.60.40.50.3
Intermittent access day 1 total infusions0.30.32.7-1.6-0.80.7-0.30.3-0.4-0.4-0.2-0.1-0.2-0.30.1-0.00.0
Intermittent access day 15 total infusions0.50.51.2-0.8-0.70.8-0.60.7-0.8-0.7-1.1-0.4-0.9-0.60.90.5-0.1
Intermittent access terminal intake (last 3 days)0.10.21.2-1.1-0.50.5-0.20.2-0.3-0.3-0.4-0.1-0.2-0.10.2-0.1-0.2
Intermittent access total infusions0.40.43.3-1.8-0.80.8-0.40.4-0.5-0.5-0.5-0.2-0.4-0.40.40.0-0.2
Intermittent access day 1 locomotion0.40.42.8-1.7-0.90.7-0.50.5-0.6-0.60.00.10.1-0.3-0.10.1-0.2
Intermittent access day 15 total locomotion1.51.73.3-1.8-1.31.4-1.41.2-1.5-1.3-1.4-0.9-1.3-1.31.31.10.3
Intermittent access total locomotion1.21.35.2-2.3-1.41.3-1.21.1-1.3-1.2-0.8-0.7-0.8-1.00.70.70.1
Intermittent access standard deviation0.10.10.20.20.4-0.40.2-0.30.20.3-0.20.20.10.2-0.1-0.3-0.4
Left kidney weight1.13.124.85.02.6-1.30.7-0.50.50.6-1.90.2-1.60.31.60.5-0.1
Right kidney weight1.13.125.15.02.7-1.90.9-0.90.90.9-1.20.4-0.90.51.00.2-0.2
Cocaine induced anxiety0.80.91.30.30.7-1.10.9-1.11.11.01.01.01.01.1-1.1-1.00.0
Post-drug Anxiety0.40.53.3-1.8-1.20.1-0.3-0.1-0.1-0.00.7-0.10.6-0.0-0.7-0.30.5
Baseline Anxiety0.60.73.9-2.0-1.21.0-0.60.6-0.7-0.60.6-0.50.4-0.6-0.40.2-0.4
Tail length1.13.212.80.70.00.4-0.90.9-1.1-0.7-3.6-1.5-3.1-1.33.11.61.3
Length with tail1.55.631.05.63.7-2.71.7-1.71.41.7-2.60.4-1.90.81.9-0.3-1.0
Length without tail6.514.348.26.95.3-4.73.8-3.83.83.81.32.91.63.1-1.6-2.8-3.3
Times rat made contact with spout3.13.54.6-0.3-1.61.6-2.01.7-1.9-1.9-2.1-2.0-2.1-2.12.12.11.9
Lifetime Intake0.30.33.2-1.8-0.50.40.1-0.2-0.1-0.10.00.10.10.1-0.1-0.5-0.5
Liver weight, left2.64.213.03.62.6-2.62.2-1.92.02.11.01.61.21.7-1.2-1.6-2.0
Liver weight, right1.22.011.33.42.0-2.20.7-0.91.11.5-0.50.9-0.10.70.1-0.3-1.1
Locomotor activity1.21.93.50.4-0.51.1-1.41.4-1.4-1.4-1.9-1.3-1.8-1.31.81.71.0
Locomotor testing distance0.40.71.40.2-0.10.6-1.00.9-0.8-1.0-1.2-0.7-1.1-0.71.11.10.8
Locomotor testing rearing0.00.00.3-0.00.10.2-0.50.0-0.2-0.20.0-0.10.1-0.1-0.10.20.2
Locomotion in novel chamber4.04.96.1-1.6-2.12.0-2.52.4-2.3-2.3-2.5-2.0-2.4-2.22.42.41.8
Locomotion in novel chamber post-restriction3.74.510.2-0.7-1.71.6-1.81.9-1.8-1.9-2.7-1.9-2.6-2.02.62.23.2
Fecal boli incidents, locomotor time 10.30.31.10.80.30.1-0.30.2-0.2-0.1-1.0-0.5-0.9-0.60.90.3-0.6
Change in fecal boli incidents, locomotor task0.20.20.9-1.0-0.40.3-0.10.4-0.1-0.20.50.10.30.1-0.30.10.6
Time >=10cm from walls, locomotor time 11.61.62.80.50.6-0.91.4-1.71.11.01.71.31.51.1-1.5-1.4-1.4
Bouts of movement, locomotor time 10.30.30.90.60.00.4-0.10.4-0.3-0.5-0.9-0.4-0.9-0.30.90.60.9
Total resting periods, locomotor time 10.20.20.60.60.10.3-0.00.4-0.2-0.4-0.8-0.3-0.7-0.20.70.40.7
Rest time, locomotor task time 10.20.21.0-0.3-0.0-0.1-0.60.6-0.10.2-1.0-0.1-0.7-0.10.60.3-0.5
Distance moved, locomotor task time 10.10.10.70.3-0.30.30.20.0-0.2-0.50.3-0.10.1-0.3-0.10.30.8
Vertical activity count, locomotor time 10.30.30.91.0-0.10.70.00.2-0.5-0.9-0.2-0.2-0.4-0.50.40.60.8
Time >=10cm from walls, locomotor time 21.71.74.21.71.5-1.41.0-1.21.31.31.01.31.11.2-1.1-1.1-2.1
Bouts of movement, locomotor time 20.80.86.02.41.2-0.90.8-0.40.50.30.21.10.30.6-0.3-0.20.1
Total resting periods, locomotor time 21.01.15.62.41.5-1.11.0-0.80.80.60.41.30.50.9-0.5-0.5-0.2
Rest time, locomotor task time 20.70.82.0-0.80.5-0.90.8-1.10.91.10.60.40.71.0-0.7-1.1-1.4
Distance moved, locomotor task time 21.31.52.70.7-1.01.1-1.21.3-1.4-1.6-1.0-1.0-1.1-1.51.11.61.2
Vertical activity count, locomotor time 21.51.62.61.5-0.41.1-0.71.2-1.3-1.5-1.6-0.8-1.6-1.31.61.50.8
Light reinforcement 10.20.32.6-1.6-0.50.6-0.10.2-0.3-0.10.4-0.20.3-0.2-0.3-0.2-0.9
Light reinforcement 20.10.10.5-0.7-0.40.50.10.1-0.4-0.30.1-0.5-0.1-0.20.10.1-0.7
Bone: marrow area0.20.51.40.90.00.2-0.70.5-0.7-0.3-1.2-0.4-1.0-0.71.10.90.5
Bone: maximum diameter0.71.46.52.51.6-1.41.2-1.11.11.10.31.10.41.0-0.3-0.7-0.5
Bone: maximum force0.91.58.62.91.6-1.41.4-1.21.11.1-0.10.70.10.8-0.0-0.7-1.0
Bone: maximum moment0.71.37.62.81.5-1.31.2-1.01.11.1-0.10.60.00.7-0.0-0.6-0.6
Mean time between licks in bursts0.30.41.3-0.7-1.10.8-0.60.7-0.6-0.80.2-0.10.1-0.5-0.10.41.1
Mean num. licks in bursts0.40.52.0-0.70.4-0.50.5-0.80.60.70.30.80.40.7-0.4-0.8-1.4
Cd content in liver2.42.63.8-1.4-1.91.9-1.81.8-1.8-2.0-1.1-1.5-1.2-1.71.21.71.3
Co content in liver1.41.63.0-1.7-1.11.3-1.31.3-1.2-0.9-1.4-1.4-1.4-0.91.41.11.1
Cu content in liver0.40.51.81.30.8-0.90.6-0.20.71.00.50.40.50.5-0.5-0.30.0
Fe content in liver5.36.414.93.93.3-3.02.8-2.72.62.71.52.21.62.3-1.6-2.1-1.9
K content in liver0.10.10.4-0.50.1-0.20.1-0.10.30.60.10.30.20.3-0.2-0.2-0.3
Mg content in liver0.40.50.9-1.0-0.50.7-0.60.7-0.6-0.5-0.8-0.6-0.8-0.60.80.60.3
Mn content in liver0.20.31.3-0.6-0.60.3-0.30.2-0.5-0.0-0.1-0.7-0.2-0.70.20.2-1.1
Na content in liver0.50.62.30.60.6-0.90.9-0.90.51.00.30.20.30.4-0.3-0.7-1.5
Rb content in liver1.21.53.1-0.40.6-0.71.0-0.81.21.21.81.31.71.3-1.7-1.3-0.9
Se content in liver4.15.06.71.52.5-2.42.5-2.52.52.61.82.11.92.4-1.9-2.4-2.1
Sr content in liver0.20.20.40.0-0.4-0.1-0.40.6-0.4-0.3-0.6-0.5-0.5-0.50.50.50.4
Zn content in liver0.30.31.81.30.8-0.5-0.20.3-0.00.1-0.70.1-0.5-0.10.50.50.4
Bone: minimum diameter0.00.00.10.4-0.10.1-0.20.4-0.1-0.10.1-0.2-0.0-0.20.00.20.3
Time in familiar zone, hab. session 10.20.20.50.70.3-0.30.4-0.30.30.10.70.40.60.3-0.6-0.3-0.0
Time in novel zone, hab. session 10.20.20.4-0.1-0.20.2-0.60.6-0.5-0.3-0.6-0.3-0.5-0.50.50.50.4
Total zone transitions, hab. session 10.81.12.9-1.0-1.70.9-1.41.2-1.2-1.0-0.9-0.9-0.7-1.40.60.80.1
Total locomotion distance, hab. session 10.30.41.20.10.1-0.30.4-0.50.50.50.61.10.80.4-0.9-0.8-0.6
Locomotion velocity, hab. session 10.20.30.7-0.7-0.30.20.1-0.30.20.30.70.80.80.3-0.8-0.7-0.7
Time in familiar zone, hab. session 20.40.40.90.80.7-0.30.7-0.70.40.21.00.60.80.5-0.8-0.5-0.4
Time in novel zone, hab. session 20.20.20.8-0.9-0.70.3-0.50.6-0.3-0.1-0.5-0.4-0.4-0.30.40.30.4
Total zone transitions, hab. session 22.22.84.1-0.9-1.81.5-1.92.0-1.8-1.5-2.0-1.6-1.8-1.91.81.71.1
Total locomotion distance, hab. session 20.50.61.4-0.8-1.01.2-1.01.0-0.9-0.8-0.8-0.3-0.6-0.80.60.60.3
Locomotion velocity, hab. session 20.60.91.7-0.9-1.21.3-1.11.1-1.0-0.9-0.9-0.4-0.8-0.90.70.80.5
Novel to familiar place preference ratio1.71.72.6-1.2-1.31.6-1.61.5-1.4-1.3-0.9-1.2-1.1-1.31.11.41.2
Novelty place preference1.61.62.6-1.2-1.31.6-1.61.6-1.3-1.3-0.7-1.2-0.9-1.30.91.41.0
Time in novel zone, NPP test1.21.32.1-0.9-1.11.3-1.41.5-1.2-1.1-0.7-1.1-0.8-1.20.81.31.0
Total zone transitions, NPP test0.50.81.7-0.3-0.90.5-1.01.3-0.9-0.6-1.1-0.9-0.9-1.00.90.80.3
Total locomotion distance, NPP test0.10.10.5-0.6-0.10.2-0.10.20.00.1-0.10.40.10.1-0.1-0.3-0.7
Locomotion velocity, NPP test0.20.30.9-0.9-0.50.7-0.60.5-0.5-0.4-0.60.1-0.5-0.30.50.2-0.2
Intraocular pressure0.30.41.50.61.2-0.60.6-0.90.50.8-0.20.6-0.10.80.1-0.5-0.5
Delta distance traveled before/after self-admin0.10.10.50.4-0.1-0.1-0.30.4-0.2-0.0-0.7-0.4-0.5-0.40.50.30.1
Delta ambulatory time before/after self-admin0.00.00.20.40.0-0.4-0.00.20.20.2-0.1-0.10.0-0.1-0.00.00.1
Parametrial fat weight0.10.20.60.7-0.20.2-0.10.3-0.4-0.8-0.4-0.2-0.3-0.50.30.30.4
Pavlov. Cond. lever latency0.30.43.21.81.0-0.20.3-0.10.0-0.3-0.30.0-0.4-0.10.50.30.2
Pavlov. Cond. magazine entry latency0.81.02.8-0.8-1.10.8-1.00.9-0.8-0.8-1.2-0.8-1.1-0.81.10.91.7
Pavlov. Cond. change in total contacts0.20.20.4-0.6-0.1-0.50.3-0.30.50.60.50.30.60.5-0.7-0.5-0.4
Pavlov. Cond. index score0.10.10.9-0.9-0.60.1-0.2-0.00.00.2-0.20.0-0.10.10.1-0.10.4
Pavlov. Cond. latency score0.10.21.3-1.2-0.70.1-0.40.2-0.10.2-0.2-0.1-0.1-0.00.1-0.00.4
Pavlov. Cond. lever contacts0.30.32.4-1.6-0.70.1-0.1-0.10.20.40.40.20.50.4-0.5-0.4-0.1
Pavlov. Cond. magazine entry number0.50.61.50.60.8-0.60.7-0.60.60.61.10.51.00.6-1.0-0.7-1.2
Pavlov. Cond. intertrial magazine entries0.10.10.20.10.0-0.30.10.10.20.30.5-0.20.4-0.0-0.4-0.1-0.4
Pavlov. Cond. lever-magazine prob. diff.0.10.10.7-0.8-0.5-0.0-0.1-0.20.20.3-0.10.2-0.00.2-0.0-0.20.5
Pavlov. Cond. response bias0.10.20.9-1.0-0.60.2-0.30.0-0.10.0-0.5-0.2-0.4-0.10.40.10.6
Pavlov. Cond. lever latency0.10.10.4-0.1-0.10.4-0.40.6-0.3-0.2-0.2-0.0-0.3-0.10.30.4-0.2
Pavlov. Cond. magazine entry latency0.20.20.5-0.5-0.70.5-0.20.1-0.3-0.60.7-0.20.5-0.2-0.5-0.00.6
Pavlov. Cond. change in total contacts0.00.10.20.5-0.2-0.1-0.0-0.1-0.2-0.2-0.1-0.5-0.1-0.40.10.10.1
Pavlov. Cond. index score0.10.10.2-0.1-0.3-0.20.2-0.40.1-0.00.4-0.10.40.0-0.4-0.30.2
Pavlov. Cond. latency score0.10.10.3-0.1-0.2-0.30.3-0.40.20.10.60.00.50.1-0.5-0.40.0
Pavlov. Cond. lever contacts0.60.81.80.30.7-0.91.1-1.31.00.90.90.80.90.9-0.9-1.2-0.1
Pavlov. Cond. magazine entry number0.20.30.70.40.8-0.60.3-0.40.50.8-0.50.4-0.30.40.3-0.2-0.8
Pavlov. Cond. intertrial magazine entries0.40.51.6-0.0-0.30.4-0.60.6-0.5-0.2-1.3-0.8-1.2-0.71.20.70.5
Pavlov. Cond. lever-magazine prob. diff.0.00.10.2-0.2-0.40.00.0-0.1-0.1-0.20.3-0.20.3-0.2-0.3-0.10.3
Pavlov. Cond. response bias0.40.51.1-0.00.3-0.60.9-1.10.70.51.00.60.90.7-0.9-1.00.0
Time in closed arm before self-admin0.60.71.60.8-0.10.3-1.01.2-0.6-0.5-1.2-0.6-1.0-0.81.01.00.8
Time in closed arm after self-admin2.22.33.51.2-0.91.0-1.41.6-1.4-1.5-1.7-1.5-1.7-1.71.71.91.7
Time in open arm before self-admin0.10.10.80.9-0.00.20.3-0.4-0.2-0.4-0.1-0.3-0.3-0.20.30.30.2
Time in open arm after self-admin0.30.31.1-1.00.1-0.00.3-0.50.20.20.70.80.60.6-0.6-0.6-0.6
Bone: periosteal estimation0.30.65.12.31.1-0.80.4-0.30.30.5-0.50.4-0.40.20.40.0-0.1
Bone: periosteal perimeter1.22.08.02.81.8-1.61.5-1.21.31.30.71.20.81.2-0.8-1.0-0.9
Bone: post-yield work1.62.23.21.21.8-1.61.5-1.61.61.61.01.71.21.7-1.2-1.5-1.2
Progressive ratio test 1 active lever presses0.40.40.9-0.4-0.50.5-0.40.6-0.6-0.7-0.9-0.4-0.8-0.50.80.60.9
Progressive ratio test 1 breakpoint0.70.71.3-0.6-0.70.7-0.70.8-0.8-1.0-1.1-0.6-1.0-0.71.00.71.1
Progressive ratio test 1 inactive lever presses1.41.53.0-0.1-0.61.4-1.11.3-1.2-1.6-1.3-0.7-1.4-1.01.41.41.7
Progressive ratio test 2 active lever presses1.82.04.1-1.4-1.01.2-1.31.3-1.5-1.3-2.0-1.2-1.8-1.31.81.30.8
Progressive ratio test 2 breakpoint2.73.14.6-1.8-1.51.7-1.71.7-1.8-1.8-2.1-1.5-2.0-1.62.01.61.3
Progressive ratio test 2 inactive lever presses1.92.24.8-0.5-0.61.4-1.31.5-1.4-1.6-2.2-0.9-2.1-1.22.11.51.4
Incentive Sensitization - Responses1.21.24.3-2.1-1.11.1-1.11.0-1.2-1.0-1.1-1.0-1.1-0.91.10.90.3
Incentive Sensitization - Breakpoint1.21.34.2-2.1-1.01.1-1.11.0-1.2-0.9-1.1-1.0-1.1-0.91.10.90.3
Sum of active levers in priming session hrs 5-63.13.04.00.51.3-1.91.8-1.91.71.81.71.81.91.6-1.9-2.0-1.9
Progressive ratio0.30.43.7-1.9-0.3-0.0-0.50.3-0.10.10.3-0.50.20.1-0.20.0-0.7
Food seeking constrained by brief footshock0.30.41.61.10.2-0.60.1-0.00.60.40.60.80.70.5-0.7-0.21.3
Seeking ratio, punishment vs. effort0.60.75.62.40.2-0.10.20.00.2-0.2-0.40.8-0.2-0.10.20.21.6
Retroperitoneal fat weight3.110.315.62.52.7-3.23.1-2.93.33.14.03.03.93.1-3.9-3.2-2.7
Reaction time number correct0.30.51.41.20.10.2-0.30.7-0.5-0.5-0.9-0.3-0.8-0.50.90.71.0
Reaction time mean minus median1.21.65.0-2.2-1.31.5-1.41.0-1.4-1.0-1.2-1.0-1.2-1.01.21.0-0.3
Reaction time mean minus median AUC1.31.75.3-2.3-1.41.8-1.41.2-1.6-1.2-1.0-1.1-1.1-1.11.11.0-0.3
Reaction time num false alarms0.40.51.5-1.2-0.90.5-0.80.6-0.7-0.4-0.6-1.1-0.6-0.70.60.70.1
Reaction time num false alarms AUC0.10.10.5-0.7-0.1-0.1-0.20.1-0.10.3-0.2-0.5-0.20.00.20.2-0.4
Reaction time trials correct on left0.30.51.41.20.10.2-0.30.7-0.5-0.5-0.9-0.3-0.8-0.50.90.71.0
Reaction time trials on left0.40.51.21.10.00.3-0.30.8-0.6-0.5-0.9-0.3-0.9-0.60.90.81.1
Reaction time mean1.11.57.1-2.7-1.81.9-1.01.3-1.1-1.20.1-0.9-0.2-0.90.20.50.2
Reaction time mean AUC0.91.26.5-2.5-1.61.8-0.80.9-0.9-1.00.2-0.7-0.1-0.80.10.30.1
Median of all reaction times0.81.05.4-2.3-1.61.6-0.51.0-0.7-0.90.8-0.60.4-0.6-0.40.10.3
Reaction time omissions0.50.62.5-1.6-1.11.2-0.60.5-0.8-0.9-0.1-0.8-0.2-0.70.20.40.2
Reaction time false alarm rate0.10.21.2-1.1-0.1-0.2-0.0-0.20.10.40.2-0.40.20.2-0.2-0.2-0.8
Reaction time premature initiation rate1.41.811.6-3.4-1.31.0-1.10.5-1.2-0.7-1.1-1.6-1.0-0.90.90.5-1.3
Reaction time premature initiations1.01.45.6-2.4-1.20.8-1.00.7-1.2-0.8-1.3-1.5-1.1-1.01.10.7-0.7
Std. dev. reaction times1.21.76.3-2.5-1.51.8-1.41.2-1.4-1.1-0.7-1.0-0.8-1.10.80.9-0.0
Reaction time trials completed0.40.51.21.10.00.3-0.30.8-0.6-0.5-0.9-0.3-0.9-0.60.90.81.1
Reaction time trials AUC0.20.41.41.20.10.1-0.20.6-0.4-0.4-0.7-0.2-0.7-0.50.70.70.9
Run reversals in cocaine runway, females0.20.22.1-1.4-0.30.5-0.20.3-0.1-0.10.30.20.20.0-0.2-0.0-0.3
Run reversals in cocaine runway, males0.30.32.41.50.2-0.20.5-0.20.2-0.00.1-0.2-0.0-0.10.00.20.8
Latency to leave start box in cocaine runway0.30.31.1-0.00.4-0.20.5-0.60.30.21.1-0.20.70.4-0.7-0.4-0.6
Latency to leave start box in cocaine runway, F0.40.51.10.60.9-0.40.9-0.80.70.61.00.30.80.7-0.7-0.6-0.3
Latency to leave start box in cocaine runway, M0.30.30.9-0.9-0.60.2-0.50.2-0.6-0.4-0.1-0.8-0.2-0.50.20.4-0.7
Std. dev. time between licks in bursts0.20.20.4-0.0-0.20.5-0.30.1-0.5-0.5-0.6-0.4-0.6-0.40.70.40.4
Total sessions with >9 infusions0.50.61.9-0.20.5-0.81.0-1.10.70.90.30.40.40.6-0.4-1.0-1.4
Short access day 1 total inactive lever presses0.60.71.0-0.7-0.71.0-0.60.8-1.0-1.0-0.9-0.7-1.0-0.91.00.70.3
Short access day 10 total inactive lever presses0.60.72.0-0.5-0.10.6-0.80.8-0.6-0.6-1.4-0.2-1.3-0.51.30.80.7
Short access day 1 total infusions1.92.03.2-0.30.9-1.11.6-1.51.31.21.71.51.61.4-1.7-1.8-1.6
Short access day 10 total infusions0.80.92.3-1.30.3-0.60.8-1.00.80.80.80.71.00.9-1.0-1.2-1.5
Short access total infusions0.70.81.6-1.10.2-0.51.0-1.00.80.70.90.71.00.8-1.0-1.3-1.0
Short access day 1 locomotion0.50.62.6-1.6-1.10.9-0.60.8-0.8-0.90.0-0.5-0.1-0.60.10.4-0.2
Short access day 10 total locomotion0.20.20.6-0.60.3-0.10.4-0.10.40.10.60.40.70.3-0.7-0.5-0.8
Short access total locomotion0.20.21.4-1.2-0.40.20.00.1-0.0-0.20.50.30.50.1-0.6-0.4-0.4
One hour access (0.3 mA shock)3.64.26.5-2.3-1.92.5-2.11.9-2.2-2.2-2.2-1.6-2.2-1.92.21.91.5
Compulsive drug intake1.01.04.2-2.1-1.41.2-1.10.8-1.0-0.90.2-0.7-0.1-0.80.10.81.1
One hour access (shock baseline)1.01.22.8-0.4-0.61.1-1.01.0-1.0-1.1-1.7-0.8-1.5-1.01.51.00.6
Social response proportion2.93.25.5-0.1-1.11.6-1.71.6-1.8-1.8-2.3-1.9-2.3-1.82.41.91.6
Social responses1.21.53.5-1.0-0.41.0-1.31.0-1.3-1.1-1.9-1.2-1.7-1.01.71.2-0.2
Social time0.91.12.3-0.8-1.51.4-1.21.3-1.2-1.30.1-1.2-0.2-1.10.21.01.0
Soleus weight0.82.35.51.82.3-1.61.3-1.61.51.70.31.80.51.6-0.5-1.0-1.8
Bone: stiffness0.50.92.81.71.1-1.11.2-1.10.90.90.30.30.30.7-0.3-0.7-1.0
Tibialis anterior weight0.62.210.83.32.4-1.71.2-1.31.11.2-1.21.0-0.80.90.8-0.5-0.9
Time to tail flick, vehicle, before self-admin0.20.20.6-0.6-0.80.4-0.40.4-0.2-0.3-0.0-0.5-0.0-0.50.00.40.4
Time to tail flick, vehicle, after self-admin0.30.31.20.40.3-0.60.7-0.70.40.60.5-0.00.50.1-0.4-0.6-1.1
Time to tail flick, test, before self-admin1.41.42.61.41.3-1.51.5-1.51.21.40.40.40.50.8-0.5-1.2-1.6
Time to tail flick, test, after self-admin2.02.13.20.91.3-1.51.7-1.61.61.41.21.21.31.3-1.3-1.8-1.8
Delta time to tail flick, vehicle, before/after SA1.51.52.50.91.3-1.11.4-1.41.11.21.20.91.11.0-1.1-1.4-1.6
Delta time to tail flick, test, before/after SA0.10.10.4-0.6-0.10.0-0.00.00.1-0.00.40.60.50.3-0.5-0.40.0
Tibia length0.61.611.53.40.9-0.2-0.10.4-0.3-0.1-1.5-0.4-1.5-0.61.51.01.1
Ambulatory time before self-admin0.10.10.2-0.40.1-0.00.3-0.40.3-0.10.40.10.40.3-0.4-0.5-0.1
Ambulatory time after self-admin0.20.20.50.20.5-0.60.4-0.40.70.30.30.20.40.4-0.4-0.5-0.1
Bone: tissue strength0.30.31.11.10.6-0.60.5-0.20.70.30.30.40.40.3-0.4-0.4-0.3
Total heroin consumption0.50.54.4-2.1-0.50.5-0.30.20.0-0.10.80.40.70.2-0.7-0.3-0.7
Bone: trabecular number3.25.119.44.43.0-2.72.5-2.12.12.20.52.20.91.8-0.9-1.7-1.8
Bone: trabecular spacing0.30.41.9-1.4-0.90.6-0.50.4-0.4-0.50.9-0.60.6-0.3-0.60.00.0
Bone: trabecular thickness3.64.310.23.22.9-2.42.4-1.92.12.10.72.41.02.0-1.0-1.7-1.7
Bone: trabecular tissue density0.10.10.40.10.30.30.50.00.1-0.10.6-0.30.30.1-0.3-0.2-0.6
Water consumed over 24 hours1.72.13.91.0-0.61.1-1.00.8-1.2-1.3-2.0-1.5-2.0-1.42.01.51.8
Number of responses in last shaping day0.10.10.20.3-0.00.4-0.20.4-0.3-0.5-0.5-0.1-0.4-0.30.40.30.2