Hub : Genes

LOC102546778

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain mRNA stability LOC102546778 0.13 0.08 1.2e-15 0.17 0.17 0.17 0.17 1.0e-15 3.2e-15 8.0e-16 7.9e-16
2 Liver mRNA stability LOC102546778 0.02 0.02 4.9e-03 0.01 0.01 0.01 0.01 8.1e-03 7.0e-03 1.7e-02 9.7e-03
3 NAcc gene expression LOC102546778 0.28 0.03 0.0e+00 0.12 0.16 0.15 0.15 1.1e-13 1.1e-17 1.2e-16 1.6e-16
4 BLA mRNA stability LOC102546778 0.09 0.06 1.0e-05 0.06 0.07 0.07 0.06 6.0e-04 1.3e-04 1.6e-04 3.5e-04
5 Brain gene expression LOC102546778 0.18 0.09 0.0e+00 0.22 0.23 0.22 0.22 8.6e-20 2.1e-21 1.1e-20 1.2e-20
6 NAcc mRNA stability LOC102546778 0.07 0.03 1.1e-11 0.1 0.1 0.09 0.1 1.6e-11 9.3e-12 2.4e-10 4.4e-11
7 Brain isoform ratio XR_005487589.1 0.03 0.03 2.5e-03 0.02 0.03 0.02 0.03 2.8e-03 1.9e-03 3.1e-03 2.0e-03
8 PL mRNA stability LOC102546778 0.1 0.07 1.7e-10 0.09 0.09 0.09 0.09 9.9e-10 1.6e-10 3.8e-10 2.7e-10
9 OFC mRNA stability LOC102546778 0.16 0.12 1.0e-03 0.12 0.05 0.09 0.09 1.1e-03 2.2e-02 3.7e-03 4.5e-03
10 pVTA mRNA stability LOC102546778 0.1 0.11 6.2e-03 0.03 0.03 0.02 0.01 1.6e-02 1.6e-02 3.4e-02 1.5e-01
11 PL gene expression LOC102546778 0.09 0.05 7.1e-12 0.11 0.1 0.1 0.1 8.6e-12 1.6e-11 1.3e-10 3.0e-11
12 BLA gene expression LOC102546778 0.06 0.05 1.9e-03 0.05 0.04 0.04 0.04 1.6e-03 5.3e-03 5.0e-03 3.7e-03
13 pVTA gene expression LOC102546778 0.1 0.05 1.6e-05 0.08 0.11 0.14 0.09 3.0e-04 2.5e-05 1.3e-06 1.4e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density10.617.818.84.34.24.14.24.34.24.24.2-4.24.2-4.2-4.3-4.1
Area under the delay curve1.01.01.41.21.11.11.01.01.01.01.0-1.11.0-1.1-1.0-0.7
BMI with tail4.313.815.63.93.94.03.93.83.83.83.7-3.53.7-3.7-3.6-3.0
BMI without tail0.00.00.10.10.10.2-0.1-0.2-0.2-0.2-0.2-0.0-0.30.10.30.3
Body weight5.824.227.65.25.15.05.15.05.05.05.0-4.55.0-5.0-4.9-3.9
Weight adjusted by age1.61.82.21.41.21.11.31.41.41.41.4-1.51.4-1.5-1.4-0.9
Bone surface12.522.123.24.84.74.74.84.74.74.74.7-4.64.7-4.6-4.8-4.5
Bone volume9.716.418.04.24.24.24.14.14.14.04.0-3.94.0-3.9-4.1-3.8
Breakpoint value in progressive ratio session0.20.20.50.40.40.40.50.50.50.50.5-0.70.5-0.5-0.4-0.3
Number of licking bursts0.80.91.3-1.2-1.1-1.2-1.0-0.9-1.0-0.9-0.90.9-0.90.90.80.9
Context. condit. distance diff. score0.20.30.70.50.50.50.50.50.50.50.5-0.60.5-0.5-0.5-0.8
Locomotion velocity, session 11.41.52.7-1.5-1.5-1.6-1.4-1.2-1.2-1.1-1.11.0-1.10.91.10.9
Locomotion distance, session 12.73.43.9-2.0-1.9-2.0-1.9-1.9-1.8-1.8-1.81.8-1.81.71.91.7
Locomotion velocity, session 20.20.20.3-0.5-0.5-0.6-0.5-0.5-0.5-0.5-0.50.5-0.50.50.40.0
Locomotion distance, session 22.33.24.0-1.9-2.0-2.0-1.9-1.8-1.8-1.8-1.81.7-1.71.71.71.2
Locomotion velocity, session 34.55.25.9-2.4-2.4-2.4-2.3-2.3-2.3-2.2-2.22.2-2.22.22.12.4
Locomotion distance, session 35.05.46.1-2.3-2.3-2.3-2.4-2.4-2.4-2.4-2.42.5-2.42.52.22.1
Stereotopy head waving bouts, day 30.80.91.80.90.80.60.91.01.01.01.1-1.01.1-1.0-1.3-0.8
Stereotopy head waving duration, day 30.40.50.80.60.50.40.60.70.70.70.8-0.80.8-0.9-0.9-0.3
Locomotion velocity, session 70.60.61.6-1.0-1.1-1.3-0.9-0.7-0.8-0.7-0.60.7-0.60.60.40.5
Locomotion distance, session 72.33.04.3-1.9-2.0-2.1-1.8-1.7-1.7-1.7-1.61.6-1.61.61.41.5
Stereotopy head waving bouts, day 70.80.91.20.90.90.90.90.90.90.90.9-0.80.9-0.8-1.1-1.1
Stereotopy head waving duration, day 71.11.41.51.21.21.21.21.21.21.21.2-1.11.2-1.1-1.2-1.0
Locomotion velocity, session 80.00.00.2-0.2-0.2-0.3-0.1-0.0-0.00.00.0-0.10.0-0.10.0-0.4
Locomotion distance, session 81.11.51.9-1.4-1.4-1.4-1.3-1.3-1.3-1.3-1.31.2-1.21.21.30.6
Degree of sensitization distance0.30.30.50.50.40.40.50.60.60.60.6-0.70.7-0.7-0.7-0.6
Degree of sensitization stereotypy0.20.20.40.50.60.60.50.40.40.40.4-0.30.3-0.2-0.3-0.5
Conditioned locomotion0.00.00.10.00.10.00.10.20.10.20.2-0.10.2-0.2-0.2-0.1
Cocaine response after cond. corrected0.00.00.20.1-0.00.0-0.0-0.0-0.0-0.0-0.00.0-0.00.00.00.5
Cocaine response after cond. not corrected0.50.61.4-0.6-0.7-0.6-0.7-0.7-0.7-0.7-0.70.7-0.70.70.71.2
Cocaine response before conditioning3.34.04.3-2.1-2.0-1.9-2.0-2.0-2.0-2.0-2.02.0-2.02.02.01.8
Saline control response0.10.20.80.20.30.20.30.40.40.40.4-0.40.4-0.4-0.5-0.9
Bone: connectivity density7.411.712.83.43.33.23.43.53.43.43.5-3.43.5-3.5-3.6-3.3
Bone: cortical apparent density0.30.41.0-0.5-0.6-0.6-0.6-0.6-0.6-0.6-0.60.6-0.60.60.51.0
Bone: cortical area8.913.414.23.73.63.53.73.73.73.73.7-3.73.7-3.6-3.8-3.3
Bone: cortical porosity0.40.40.6-0.5-0.4-0.3-0.6-0.7-0.6-0.7-0.70.7-0.70.70.80.7
Bone: cortical porosity0.70.81.0-0.8-0.7-0.6-0.8-0.9-0.9-0.9-0.91.0-1.01.01.00.9
Bone: cortical thickness2.84.65.22.22.12.02.12.22.22.22.2-2.22.2-2.2-2.3-1.8
Bone: cortical thickness0.00.00.1-0.0-0.1-0.20.00.10.10.10.2-0.20.2-0.2-0.3-0.1
Bone: cortical tissue density0.40.51.2-0.6-0.7-0.7-0.7-0.7-0.7-0.7-0.70.7-0.70.70.61.1
Condit. Reinf. active minus inactive responses0.10.10.1-0.3-0.3-0.3-0.3-0.2-0.2-0.2-0.20.2-0.20.20.20.3
Condit. Reinf. active-inactive response ratio0.30.30.30.50.50.50.50.60.50.60.6-0.50.6-0.6-0.6-0.4
Condit. Reinf. active responses0.60.81.0-1.0-1.0-1.0-0.9-0.9-0.9-0.9-0.90.9-0.80.80.80.8
Condit. Reinf. inactive responses2.93.53.9-2.0-1.9-1.9-1.9-1.9-1.9-1.9-1.91.8-1.91.91.91.5
Incentive salience index mean0.00.00.00.10.10.00.10.10.10.10.1-0.10.1-0.1-0.1-0.1
Condit. Reinf. lever presses0.10.20.30.50.50.60.40.40.40.30.3-0.30.3-0.3-0.3-0.4
Condit. Reinf. active minus inactive responses0.00.00.20.20.30.50.20.00.00.0-0.00.1-0.10.10.1-0.3
Condit. Reinf. active-inactive response ratio0.20.20.4-0.2-0.00.2-0.2-0.4-0.4-0.4-0.50.5-0.60.60.6-0.1
Condit. Reinf. active responses0.10.10.2-0.3-0.2-0.1-0.3-0.4-0.4-0.4-0.40.5-0.50.50.40.3
Condit. Reinf. inactive responses0.70.81.5-0.9-1.0-1.0-0.9-0.9-0.9-0.9-0.90.8-0.90.80.81.2
Condit. Reinf. lever presses0.00.00.10.00.00.00.00.00.00.00.0-0.00.0-0.0-0.1-0.3
Condit. Reinf. lever reinforcers received0.40.50.7-0.7-0.6-0.5-0.7-0.8-0.8-0.8-0.80.8-0.80.80.80.5
Conditioned reinforcement - actives1.81.82.1-1.2-1.3-1.3-1.3-1.4-1.4-1.4-1.41.3-1.41.41.51.1
Conditioned reinforcement - inactives2.62.94.0-1.7-1.7-1.7-1.7-1.7-1.7-1.7-1.72.0-1.71.61.71.4
Conditioned locomotion0.50.60.9-0.9-0.6-0.6-0.7-0.7-0.7-0.7-0.71.0-0.70.70.90.7
Patch foraging indifference point 0 sec3.25.17.6-2.6-2.6-2.8-2.4-2.2-2.2-2.1-2.12.2-2.02.12.02.0
Patch foraging indifference point AUC0.30.40.5-0.7-0.6-0.6-0.6-0.6-0.6-0.7-0.60.7-0.60.70.50.2
Delay disc. indifference point, 0s delay1.41.62.11.21.41.41.31.21.21.21.2-1.31.2-1.5-1.1-1.1
Delay disc. indifference point, 16s delay0.80.81.01.01.01.01.00.90.90.90.9-0.90.9-1.0-0.8-0.5
Delay disc. indifference point, 2s delay1.82.02.81.71.51.51.41.41.41.41.4-1.41.3-1.5-1.4-1.4
Delay disc. indifference point, 24s delay1.11.11.41.11.01.01.11.11.11.11.1-1.01.1-1.2-1.1-0.4
Delay disc. indifference point, 4s delay0.50.50.80.90.80.90.70.60.70.60.6-0.50.6-0.7-0.6-0.7
Delay disc. indifference point, 8s delay2.32.32.81.71.51.51.51.51.61.51.5-1.71.5-1.7-1.5-1.1
Indifference point function ln k4.56.27.52.72.62.72.62.52.52.52.5-2.52.5-2.4-2.4-1.7
Indifference point function log k4.56.27.52.72.62.72.62.52.52.52.5-2.52.5-2.4-2.4-1.7
Patch foraging total patch changes 0 sec3.04.87.1-2.5-2.5-2.7-2.3-2.1-2.2-2.1-2.02.2-2.02.01.91.8
Patch foraging total patch changes 12 sec3.34.26.1-2.4-2.3-2.5-2.2-2.0-2.0-2.0-1.92.0-1.91.91.81.7
Patch foraging total patch changes 18 sec5.26.78.6-2.9-2.8-2.9-2.7-2.6-2.6-2.6-2.52.7-2.52.62.31.8
Patch foraging total patch changes 24 sec3.03.64.9-2.2-2.1-2.2-2.0-1.9-1.9-1.8-1.81.9-1.81.81.61.5
Patch foraging total patch changes 6 sec3.75.48.0-2.6-2.7-2.8-2.5-2.3-2.3-2.3-2.22.1-2.12.12.02.1
Patch foraging time to switch 0 sec2.43.74.7-1.9-2.0-2.0-1.9-1.9-1.9-1.9-1.92.2-1.81.91.82.0
Patch foraging water rate 0 sec2.84.55.12.22.22.32.22.12.12.12.1-2.02.1-2.0-2.1-2.0
Patch foraging water rate 12 sec3.85.86.22.52.42.32.42.42.42.42.4-2.52.4-2.4-2.5-2.3
Patch foraging water rate 18 sec0.30.30.40.70.60.60.60.60.60.60.6-0.60.6-0.6-0.5-0.3
Patch foraging water rate 24 sec3.95.46.32.52.52.52.42.32.32.22.2-2.52.2-2.2-2.2-2.3
Patch foraging water rate 6 sec4.26.17.42.72.72.72.62.52.52.42.4-2.42.4-2.2-2.4-2.4
Seeking ratio, delayed vs. immediate footshock0.30.40.80.60.70.70.60.60.60.60.6-0.50.5-0.6-0.5-0.9
Distance traveled before self-admin1.41.52.1-1.4-1.4-1.4-1.3-1.2-1.2-1.2-1.11.0-1.11.11.11.3
Distance traveled after self-admin0.30.30.6-0.8-0.6-0.7-0.5-0.5-0.5-0.5-0.50.5-0.50.50.40.6
Extensor digitorum longus weight3.915.518.94.34.24.34.14.04.03.93.9-3.73.8-3.9-3.6-3.3
Bone: elastic displacement4.45.06.3-2.4-2.4-2.5-2.3-2.2-2.2-2.2-2.22.0-2.12.02.22.4
Bone: elastic work0.10.10.20.30.20.20.20.20.20.30.2-0.30.3-0.3-0.20.4
Bone: endosteal estimation8.518.620.94.44.44.34.34.34.34.34.3-4.24.2-4.2-4.2-4.6
Bone: endosteal perimeter7.014.615.63.93.93.93.93.83.83.83.8-3.73.7-3.7-3.7-3.9
Epididymis fat weight0.10.30.60.50.50.40.50.60.60.60.6-0.50.6-0.8-0.7-0.5
Delta time in closed arm before/after self-admin0.20.20.30.20.50.40.50.50.50.50.5-0.50.5-0.5-0.5-0.5
Delta time in open arm before/after self-admin4.34.14.4-2.0-2.1-2.1-2.1-2.1-2.1-2.1-2.12.0-2.12.02.11.7
Diff in mean of infusions in LGA sessions1.82.03.51.61.41.31.41.41.41.41.4-1.91.4-1.4-1.3-1.1
Delay discount exponential model param0.91.01.4-1.2-1.0-1.1-1.0-1.0-1.0-0.9-0.91.0-0.91.10.90.6
Extinction: sum of active levers before priming0.60.61.20.80.80.80.80.80.80.80.8-1.10.8-0.8-0.7-0.4
Active lever presses in extinction session 60.40.40.40.60.60.50.60.60.60.60.7-0.70.7-0.6-0.6-0.6
Bone: final force11.117.920.24.54.44.44.34.34.34.24.2-4.24.2-4.2-4.1-3.8
Bone: final moment12.119.622.24.74.64.74.54.44.54.44.4-4.44.3-4.3-4.3-3.9
Food consumed during 24 hour testing period1.82.12.71.51.51.41.51.51.51.41.4-1.41.4-1.3-1.5-1.6
Glucose0.00.00.1-0.3-0.2-0.3-0.10.00.00.10.10.00.1-0.2-0.1-0.0
Heart weight0.10.10.10.30.30.30.30.30.30.30.3-0.30.3-0.2-0.20.1
Delay discount hyperbolic model param1.01.01.5-1.2-1.1-1.1-1.0-1.0-1.0-1.0-1.01.0-0.91.10.90.7
Intermittent access intake day 1-15 change1.51.52.0-1.1-1.0-0.9-1.1-1.3-1.2-1.3-1.31.3-1.31.41.31.2
Intermittent access intake escalation1.01.01.5-0.8-0.8-0.6-0.9-1.0-1.0-1.1-1.11.0-1.11.21.11.0
Intermittent access intake escalation 21.61.62.2-1.1-1.0-0.9-1.2-1.3-1.3-1.4-1.41.4-1.41.51.41.2
Intermitt. access day 1 inactive lever presses1.81.92.6-1.2-1.2-1.1-1.3-1.4-1.4-1.4-1.51.5-1.51.41.61.5
Intermitt. access day 15 inactive lever presses1.01.11.8-0.9-0.8-0.7-1.0-1.0-1.0-1.1-1.11.3-1.11.11.20.9
Intermitt. access escalation Index0.30.20.5-0.5-0.6-0.7-0.5-0.5-0.5-0.4-0.40.4-0.40.40.30.5
Intermittent access day 1 total infusions1.31.51.7-1.1-1.3-1.3-1.3-1.2-1.2-1.2-1.21.3-1.21.21.31.0
Intermittent access day 15 total infusions3.03.43.8-1.7-1.8-1.8-1.9-1.9-1.9-1.9-1.91.9-1.92.01.91.6
Intermittent access terminal intake (last 3 days)3.33.64.1-1.7-1.8-1.8-1.9-1.9-1.9-2.0-1.92.0-2.02.01.91.6
Intermittent access total infusions3.03.33.7-1.6-1.8-1.7-1.8-1.9-1.9-1.9-1.91.8-1.91.91.91.6
Intermittent access day 1 locomotion1.01.01.3-1.0-1.1-1.2-1.1-1.0-1.0-1.0-1.01.1-0.90.91.00.9
Intermittent access day 15 total locomotion2.02.22.7-1.5-1.4-1.4-1.4-1.5-1.5-1.4-1.51.6-1.51.41.61.5
Intermittent access total locomotion4.04.55.1-2.2-2.2-2.2-2.2-2.1-2.1-2.1-2.12.3-2.12.02.22.0
Intermittent access standard deviation0.50.50.9-0.5-0.5-0.4-0.6-0.7-0.7-0.7-0.81.0-0.80.80.80.4
Left kidney weight0.41.21.91.41.31.41.21.11.11.11.0-1.11.0-1.0-1.0-0.5
Right kidney weight2.46.88.02.82.72.72.72.72.72.72.7-2.52.6-2.6-2.6-1.8
Cocaine induced anxiety1.21.32.31.51.11.11.11.11.11.11.1-1.11.1-1.1-1.1-1.4
Post-drug Anxiety5.56.17.92.82.52.52.52.52.52.42.4-2.52.4-2.4-2.4-2.3
Baseline Anxiety0.91.01.41.01.01.01.01.01.01.01.0-1.21.0-1.0-1.0-0.3
Tail length0.10.30.5-0.4-0.5-0.5-0.6-0.6-0.6-0.6-0.60.6-0.60.60.60.7
Length with tail1.96.88.12.82.72.72.72.72.72.72.7-2.22.7-2.6-2.7-1.9
Length without tail7.215.717.04.14.03.94.14.14.14.14.1-3.44.1-4.0-4.1-3.3
Times rat made contact with spout0.10.10.2-0.4-0.3-0.3-0.3-0.4-0.4-0.4-0.40.4-0.40.40.40.2
Lifetime Intake3.23.63.9-1.7-1.9-1.9-1.9-1.9-1.9-1.9-1.91.9-1.92.01.91.6
Liver weight, left1.82.93.11.71.81.71.81.81.81.81.8-1.71.7-1.7-1.6-1.4
Liver weight, right1.52.52.91.71.61.61.61.61.61.61.6-1.71.6-1.5-1.6-1.3
Locomotor activity1.52.34.1-1.4-1.6-1.6-1.5-1.5-1.5-1.5-1.51.4-1.51.31.42.0
Locomotor testing distance3.45.77.6-2.4-2.5-2.5-2.5-2.4-2.4-2.4-2.42.0-2.32.22.22.8
Locomotor testing rearing2.53.84.3-2.0-2.1-2.1-2.1-2.0-2.0-2.0-2.01.6-2.01.81.91.9
Locomotion in novel chamber0.81.01.91.21.31.41.10.90.90.90.8-0.80.8-0.7-0.8-1.1
Locomotion in novel chamber post-restriction0.10.10.20.40.40.50.30.20.20.20.2-0.10.2-0.1-0.2-0.4
Fecal boli incidents, locomotor time 12.22.43.1-1.5-1.5-1.5-1.6-1.6-1.6-1.6-1.61.4-1.61.61.61.8
Change in fecal boli incidents, locomotor task1.41.31.61.21.11.01.11.21.21.21.2-1.01.2-1.1-1.2-1.0
Time >=10cm from walls, locomotor time 10.10.10.20.0-0.0-0.10.10.20.20.30.3-0.20.3-0.3-0.4-0.3
Bouts of movement, locomotor time 10.00.00.2-0.20.10.10.10.10.10.10.1-0.10.1-0.30.10.4
Total resting periods, locomotor time 10.20.30.7-0.8-0.5-0.5-0.5-0.4-0.4-0.4-0.40.4-0.40.30.60.9
Rest time, locomotor task time 10.60.61.0-1.0-0.8-0.8-0.7-0.7-0.7-0.7-0.71.0-0.61.00.70.7
Distance moved, locomotor task time 10.00.00.10.10.10.10.20.20.20.20.2-0.30.2-0.3-0.3-0.3
Vertical activity count, locomotor time 11.41.52.11.41.11.11.11.21.11.11.2-1.41.1-1.4-1.2-1.2
Time >=10cm from walls, locomotor time 20.60.60.8-0.6-0.8-0.8-0.8-0.9-0.9-0.9-0.90.7-0.90.80.80.4
Bouts of movement, locomotor time 22.83.03.71.71.91.91.81.71.81.71.7-1.91.7-1.9-1.6-1.3
Total resting periods, locomotor time 23.23.44.11.82.02.01.91.81.91.81.8-1.91.8-2.0-1.7-1.3
Rest time, locomotor task time 20.00.00.1-0.2-0.1-0.2-0.00.00.00.00.10.20.10.1-0.10.4
Distance moved, locomotor task time 20.00.00.1-0.1-0.2-0.2-0.2-0.2-0.2-0.2-0.20.1-0.20.30.2-0.3
Vertical activity count, locomotor time 20.00.00.30.30.10.20.10.00.00.00.0-0.20.0-0.0-0.1-0.5
Light reinforcement 12.64.75.8-2.2-2.0-1.9-2.2-2.3-2.3-2.3-2.32.0-2.32.42.31.8
Light reinforcement 20.60.81.4-0.7-0.7-0.5-0.9-1.0-1.0-1.0-1.10.7-1.11.01.20.8
Bone: marrow area8.318.020.64.34.34.24.34.24.24.24.2-4.24.2-4.1-4.2-4.5
Bone: maximum diameter3.05.56.32.32.32.22.32.42.42.42.4-2.42.4-2.4-2.5-2.3
Bone: maximum force16.027.630.75.55.45.45.45.35.35.35.2-5.25.2-5.2-5.1-4.7
Bone: maximum moment17.129.533.05.75.65.65.65.55.55.45.4-5.45.4-5.4-5.3-4.9
Mean time between licks in bursts0.00.00.0-0.1-0.1-0.1-0.1-0.1-0.1-0.1-0.10.1-0.10.10.10.0
Mean num. licks in bursts0.10.20.40.50.50.60.40.30.40.30.3-0.30.3-0.3-0.1-0.4
Cd content in liver0.80.91.2-1.0-0.9-0.9-0.9-1.0-1.0-1.0-1.01.1-1.01.00.90.8
Co content in liver1.11.32.7-1.0-1.0-1.0-1.1-1.1-1.1-1.1-1.11.7-1.11.11.11.5
Cu content in liver0.50.60.90.70.80.70.80.80.90.90.9-0.70.9-0.9-0.7-0.5
Fe content in liver0.60.71.0-0.9-0.9-0.9-0.9-0.8-0.8-0.8-0.80.9-0.70.70.81.0
K content in liver0.10.10.20.20.10.10.20.30.30.30.3-0.10.4-0.4-0.3-0.0
Mg content in liver0.10.10.2-0.3-0.3-0.4-0.3-0.2-0.3-0.3-0.20.4-0.20.30.10.3
Mn content in liver0.10.10.20.40.40.40.40.40.40.40.4-0.40.4-0.4-0.4-0.1
Na content in liver0.10.10.2-0.4-0.4-0.4-0.3-0.3-0.3-0.3-0.30.1-0.30.20.30.4
Rb content in liver0.81.01.8-1.2-1.2-1.3-1.1-0.9-1.0-0.9-0.91.0-0.80.80.80.8
Se content in liver1.11.32.0-1.3-1.3-1.4-1.2-1.1-1.1-1.1-1.01.4-1.01.00.91.0
Sr content in liver0.10.10.30.30.20.20.30.30.30.30.3-0.20.3-0.3-0.5-0.5
Zn content in liver2.62.93.7-1.8-1.8-1.8-1.8-1.7-1.7-1.7-1.71.9-1.61.61.61.3
Bone: minimum diameter9.417.619.14.44.34.34.34.24.24.24.2-4.14.1-4.0-4.1-4.0
Time in familiar zone, hab. session 10.20.10.3-0.3-0.3-0.2-0.3-0.4-0.4-0.4-0.40.4-0.50.40.50.2
Time in novel zone, hab. session 10.20.20.30.40.40.30.40.40.40.50.5-0.50.5-0.5-0.5-0.2
Total zone transitions, hab. session 10.30.40.5-0.6-0.5-0.5-0.6-0.6-0.6-0.6-0.70.6-0.70.60.70.6
Total locomotion distance, hab. session 10.00.00.2-0.1-0.2-0.3-0.10.00.00.10.1-0.10.1-0.2-0.20.4
Locomotion velocity, hab. session 10.00.00.1-0.0-0.1-0.20.00.10.10.20.2-0.20.2-0.3-0.30.2
Time in familiar zone, hab. session 20.60.71.10.91.01.00.90.70.80.70.7-0.70.7-0.7-0.6-1.0
Time in novel zone, hab. session 20.50.51.0-0.9-0.9-1.0-0.8-0.6-0.7-0.6-0.60.5-0.50.50.50.9
Total zone transitions, hab. session 20.30.40.4-0.6-0.6-0.6-0.6-0.6-0.6-0.6-0.60.6-0.60.60.60.6
Total locomotion distance, hab. session 20.10.10.3-0.4-0.5-0.5-0.4-0.3-0.3-0.3-0.30.3-0.30.20.10.3
Locomotion velocity, hab. session 20.00.00.1-0.2-0.3-0.4-0.2-0.2-0.2-0.2-0.10.2-0.10.1-0.10.2
Novel to familiar place preference ratio1.71.82.01.41.41.41.41.41.41.41.4-1.41.4-1.4-1.3-0.8
Novelty place preference1.21.21.51.11.11.11.11.21.21.21.2-1.21.2-1.2-1.1-0.5
Time in novel zone, NPP test1.01.01.21.01.00.91.01.01.01.11.1-1.11.1-1.1-1.0-0.4
Total zone transitions, NPP test1.62.23.1-1.7-1.7-1.8-1.6-1.5-1.5-1.4-1.41.3-1.41.31.41.4
Total locomotion distance, NPP test1.92.63.8-1.8-1.9-2.0-1.7-1.6-1.6-1.6-1.51.5-1.51.41.31.4
Locomotion velocity, NPP test1.11.52.4-1.4-1.5-1.6-1.3-1.2-1.2-1.2-1.21.1-1.11.01.01.0
Intraocular pressure7.510.411.0-3.3-3.2-3.2-3.3-3.3-3.3-3.3-3.33.2-3.33.23.32.7
Delta distance traveled before/after self-admin0.10.10.10.20.30.40.30.30.30.30.3-0.10.3-0.3-0.3-0.3
Delta ambulatory time before/after self-admin0.00.00.0-0.00.10.10.10.00.00.00.00.20.0-0.0-0.0-0.1
Parametrial fat weight2.34.46.1-2.2-2.0-2.0-2.1-2.1-2.1-2.1-2.12.5-2.12.32.11.7
Pavlov. Cond. lever latency0.20.20.40.20.20.10.40.50.50.50.5-0.60.6-0.7-0.4-0.5
Pavlov. Cond. magazine entry latency0.10.10.30.40.50.60.30.20.20.20.1-0.10.10.0-0.0-0.2
Pavlov. Cond. change in total contacts0.10.10.30.40.40.60.30.10.10.10.00.0-0.00.2-0.0-0.0
Pavlov. Cond. index score0.00.00.20.30.30.40.10.00.0-0.0-0.00.1-0.10.3-0.00.1
Pavlov. Cond. latency score0.00.00.10.10.20.30.0-0.1-0.1-0.2-0.10.2-0.20.40.00.1
Pavlov. Cond. lever contacts0.60.71.1-0.6-0.6-0.4-0.7-0.8-0.8-0.9-0.90.9-1.01.00.91.0
Pavlov. Cond. magazine entry number0.00.00.1-0.0-0.1-0.20.00.10.10.20.2-0.20.2-0.3-0.20.0
Pavlov. Cond. intertrial magazine entries0.70.92.4-1.2-1.3-1.5-1.1-0.8-0.8-0.7-0.70.6-0.60.50.60.8
Pavlov. Cond. lever-magazine prob. diff.0.10.20.50.60.60.70.50.30.30.30.3-0.20.2-0.1-0.3-0.2
Pavlov. Cond. response bias0.10.10.2-0.1-0.10.1-0.2-0.3-0.3-0.3-0.30.4-0.40.50.30.3
Pavlov. Cond. lever latency0.10.10.40.50.50.70.40.30.30.30.3-0.20.2-0.1-0.10.4
Pavlov. Cond. magazine entry latency0.91.02.30.70.70.50.81.01.01.01.1-1.11.1-1.2-1.1-1.5
Pavlov. Cond. change in total contacts1.21.63.21.11.11.11.21.21.21.21.2-1.21.2-1.3-1.3-1.8
Pavlov. Cond. index score0.40.52.10.20.20.10.40.60.60.60.7-0.70.7-0.8-0.8-1.4
Pavlov. Cond. latency score0.40.52.30.30.30.10.40.60.60.60.7-0.70.7-0.9-0.8-1.5
Pavlov. Cond. lever contacts0.20.30.6-0.7-0.7-0.8-0.6-0.5-0.6-0.5-0.50.5-0.50.40.4-0.2
Pavlov. Cond. magazine entry number1.82.24.5-1.1-1.1-0.9-1.3-1.4-1.4-1.5-1.51.6-1.61.71.62.1
Pavlov. Cond. intertrial magazine entries5.26.87.8-2.5-2.4-2.3-2.5-2.6-2.6-2.6-2.62.7-2.72.82.62.8
Pavlov. Cond. lever-magazine prob. diff.0.70.92.60.60.50.40.70.90.80.90.9-1.01.0-1.1-1.0-1.6
Pavlov. Cond. response bias0.10.10.2-0.4-0.3-0.4-0.3-0.2-0.2-0.2-0.10.1-0.10.00.1-0.5
Time in closed arm before self-admin1.31.51.61.31.31.21.31.31.31.31.3-1.01.3-1.3-1.2-1.0
Time in closed arm after self-admin0.70.70.80.60.90.80.90.90.90.90.9-0.70.9-0.9-0.9-0.8
Time in open arm before self-admin0.60.71.40.80.70.60.80.80.80.80.9-1.20.9-0.8-0.9-0.4
Time in open arm after self-admin0.20.20.3-0.3-0.5-0.5-0.5-0.5-0.5-0.5-0.50.3-0.50.50.60.5
Bone: periosteal estimation11.924.626.15.15.04.95.05.05.04.95.0-4.94.9-4.8-5.0-4.9
Bone: periosteal perimeter10.317.218.34.34.34.24.24.24.24.14.1-4.14.1-4.0-4.1-3.9
Bone: post-yield work9.913.514.73.83.73.73.73.73.73.73.6-3.63.6-3.7-3.5-3.8
Progressive ratio test 1 active lever presses6.16.48.2-2.6-2.8-2.9-2.7-2.5-2.5-2.5-2.42.5-2.42.42.42.3
Progressive ratio test 1 breakpoint5.65.87.2-2.5-2.6-2.7-2.5-2.4-2.4-2.4-2.32.4-2.32.32.32.2
Progressive ratio test 1 inactive lever presses3.64.04.7-1.8-2.0-1.9-2.0-2.0-2.0-2.0-2.02.0-2.01.92.22.0
Progressive ratio test 2 active lever presses2.83.03.4-1.5-1.8-1.7-1.8-1.8-1.8-1.8-1.81.7-1.81.81.81.5
Progressive ratio test 2 breakpoint3.43.94.3-1.8-2.0-1.9-2.0-2.0-2.0-2.0-2.01.9-2.02.12.01.8
Progressive ratio test 2 inactive lever presses2.63.03.6-1.5-1.6-1.6-1.7-1.8-1.8-1.8-1.81.9-1.81.81.91.6
Incentive Sensitization - Responses0.00.00.10.30.20.20.10.0-0.0-0.0-0.0-0.1-0.10.10.10.0
Incentive Sensitization - Breakpoint0.00.00.10.20.00.1-0.0-0.1-0.1-0.2-0.1-0.0-0.20.20.20.1
Sum of active levers in priming session hrs 5-60.10.10.4-0.6-0.3-0.4-0.2-0.2-0.2-0.1-0.10.1-0.10.20.20.1
Progressive ratio0.20.20.5-0.5-0.6-0.7-0.5-0.4-0.4-0.4-0.40.0-0.30.30.20.4
Food seeking constrained by brief footshock0.60.71.3-0.9-1.0-1.1-0.9-0.8-0.8-0.8-0.80.3-0.70.60.80.9
Seeking ratio, punishment vs. effort0.00.00.00.10.10.20.10.00.10.00.00.10.0-0.00.10.0
Retroperitoneal fat weight0.82.54.9-1.7-1.7-1.8-1.6-1.5-1.5-1.5-1.52.2-1.41.51.31.1
Reaction time number correct1.92.73.61.71.61.61.61.61.61.61.6-1.71.6-1.7-1.7-1.9
Reaction time mean minus median8.611.413.7-3.5-3.3-3.3-3.4-3.4-3.4-3.4-3.43.7-3.43.43.42.8
Reaction time mean minus median AUC5.97.78.7-2.9-2.8-2.7-2.8-2.8-2.8-2.8-2.83.0-2.82.92.82.4
Reaction time num false alarms1.72.43.3-1.6-1.5-1.6-1.5-1.5-1.6-1.5-1.51.8-1.51.61.41.3
Reaction time num false alarms AUC2.43.24.1-1.9-1.8-1.8-1.8-1.8-1.8-1.8-1.82.0-1.81.81.71.7
Reaction time trials correct on left1.92.73.61.71.61.61.61.61.61.61.6-1.71.6-1.7-1.7-1.9
Reaction time trials on left1.52.23.11.51.41.41.41.51.51.41.4-1.51.5-1.5-1.5-1.7
Reaction time mean0.91.21.8-1.1-1.1-1.1-1.1-1.1-1.1-1.0-1.01.2-1.01.01.01.3
Reaction time mean AUC0.50.71.3-0.9-0.8-0.8-0.8-0.8-0.8-0.8-0.81.0-0.80.70.71.2
Median of all reaction times0.00.00.3-0.1-0.0-0.0-0.0-0.0-0.00.00.00.10.0-0.0-0.10.6
Reaction time omissions9.913.614.4-3.8-3.7-3.7-3.8-3.8-3.7-3.7-3.73.6-3.73.63.73.3
Reaction time false alarm rate3.04.25.0-2.1-2.0-1.9-2.0-2.0-2.0-2.0-2.02.2-2.02.12.02.2
Reaction time premature initiation rate7.19.410.6-3.0-3.0-2.9-3.1-3.1-3.1-3.1-3.23.3-3.13.03.22.8
Reaction time premature initiations3.04.25.0-1.9-2.0-1.9-2.1-2.1-2.1-2.1-2.12.2-2.12.02.11.6
Std. dev. reaction times6.59.110.8-3.2-3.0-3.0-3.0-3.0-3.0-3.0-3.03.3-3.02.93.02.7
Reaction time trials completed1.52.23.11.51.41.41.41.51.51.41.4-1.51.5-1.5-1.5-1.7
Reaction time trials AUC2.43.44.31.91.81.81.81.81.81.81.8-1.81.8-1.9-1.9-2.1
Run reversals in cocaine runway, females0.00.00.20.40.30.40.20.10.20.10.1-0.10.00.20.1-0.1
Run reversals in cocaine runway, males1.51.51.7-1.3-1.2-1.1-1.2-1.2-1.2-1.2-1.21.3-1.21.21.21.1
Latency to leave start box in cocaine runway0.00.00.0-0.1-0.1-0.1-0.1-0.1-0.1-0.2-0.10.1-0.10.00.10.1
Latency to leave start box in cocaine runway, F1.82.02.2-1.4-1.5-1.5-1.5-1.5-1.5-1.5-1.41.2-1.41.31.31.3
Latency to leave start box in cocaine runway, M2.12.02.31.41.51.51.51.41.41.41.4-1.21.4-1.4-1.4-1.4
Std. dev. time between licks in bursts1.31.61.8-1.3-1.3-1.3-1.3-1.3-1.3-1.3-1.31.3-1.31.31.10.7
Total sessions with >9 infusions1.71.82.3-1.3-1.4-1.4-1.4-1.3-1.4-1.4-1.31.5-1.31.41.31.2
Short access day 1 total inactive lever presses1.82.02.8-1.4-1.4-1.4-1.4-1.4-1.4-1.4-1.41.7-1.41.41.41.2
Short access day 10 total inactive lever presses0.10.10.1-0.3-0.10.0-0.1-0.2-0.2-0.2-0.30.3-0.30.20.40.3
Short access day 1 total infusions0.20.20.4-0.5-0.6-0.7-0.5-0.5-0.5-0.5-0.40.4-0.40.50.40.3
Short access day 10 total infusions1.81.92.6-1.5-1.5-1.6-1.5-1.4-1.4-1.3-1.31.6-1.31.31.31.2
Short access total infusions1.11.31.8-1.2-1.3-1.3-1.2-1.1-1.1-1.1-1.11.1-1.11.11.00.9
Short access day 1 locomotion0.30.30.7-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.50.8-0.50.50.50.6
Short access day 10 total locomotion0.10.20.4-0.3-0.4-0.4-0.4-0.4-0.4-0.3-0.40.6-0.30.30.40.4
Short access total locomotion0.60.71.2-0.9-0.8-0.8-0.8-0.8-0.8-0.8-0.81.1-0.80.70.90.7
One hour access (0.3 mA shock)0.30.40.7-0.3-0.4-0.3-0.6-0.7-0.6-0.7-0.70.6-0.80.80.80.7
Compulsive drug intake1.41.41.81.11.31.31.21.21.21.21.2-1.31.1-1.1-1.2-0.9
One hour access (shock baseline)0.30.30.5-0.3-0.5-0.4-0.5-0.6-0.6-0.6-0.60.7-0.70.70.70.5
Social response proportion0.20.20.4-0.4-0.4-0.4-0.4-0.4-0.4-0.5-0.50.4-0.50.70.50.5
Social responses8.410.811.9-3.4-3.3-3.2-3.3-3.3-3.3-3.3-3.33.2-3.33.43.33.1
Social time0.10.10.40.30.30.30.20.10.10.10.1-0.70.1-0.10.20.6
Soleus weight0.72.02.81.51.61.71.51.41.51.41.4-0.81.4-1.4-1.3-1.1
Bone: stiffness18.729.533.25.85.65.75.65.45.45.45.4-5.35.3-5.2-5.3-5.3
Tibialis anterior weight1.03.46.22.22.32.52.01.71.81.71.6-2.01.5-1.5-1.4-1.3
Time to tail flick, vehicle, before self-admin0.70.80.9-0.7-0.9-0.9-0.9-0.9-0.9-0.9-0.90.8-0.91.00.90.8
Time to tail flick, vehicle, after self-admin0.30.40.60.80.70.70.60.60.60.60.5-0.40.5-0.6-0.5-0.5
Time to tail flick, test, before self-admin0.20.20.4-0.4-0.4-0.4-0.4-0.4-0.4-0.4-0.40.3-0.40.50.60.5
Time to tail flick, test, after self-admin0.30.30.60.80.70.80.60.60.60.50.5-0.50.5-0.5-0.4-0.4
Delta time to tail flick, vehicle, before/after SA0.40.40.60.60.80.80.70.70.70.60.6-0.40.6-0.7-0.6-0.6
Delta time to tail flick, test, before/after SA0.20.20.40.50.60.60.50.40.40.40.4-0.30.4-0.4-0.4-0.6
Tibia length6.618.620.44.44.34.24.44.44.44.44.4-3.74.4-4.3-4.5-4.3
Ambulatory time before self-admin4.04.24.7-2.2-2.2-2.2-2.1-2.1-2.1-2.0-2.01.8-2.02.02.01.9
Ambulatory time after self-admin2.12.43.3-1.8-1.5-1.6-1.5-1.5-1.5-1.5-1.51.6-1.51.51.41.4
Bone: tissue strength1.81.72.01.41.41.41.41.31.31.31.3-1.31.3-1.4-1.2-1.0
Total heroin consumption1.92.22.71.41.51.41.51.51.51.51.5-1.71.5-1.5-1.4-1.4
Bone: trabecular number6.910.811.93.33.23.13.33.33.33.33.3-3.23.3-3.3-3.4-3.3
Bone: trabecular spacing2.63.43.8-1.9-1.8-1.7-1.8-1.9-1.8-1.8-1.91.8-1.91.91.91.9
Bone: trabecular thickness0.10.10.30.10.10.3-0.0-0.2-0.2-0.2-0.30.3-0.30.40.30.5
Bone: trabecular tissue density0.00.10.10.10.20.40.1-0.1-0.1-0.2-0.20.3-0.20.40.20.4
Water consumed over 24 hours0.00.00.0-0.0-0.1-0.10.00.10.10.10.1-0.10.1-0.1-0.20.0
Number of responses in last shaping day0.00.00.10.30.30.30.20.10.10.10.1-0.20.00.0-0.0-0.1