LOC102546625

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	LOC102546625	0.12	0.07	3.9e-16	0.1	0.09	0.1	0.1	8.5e-15	4.3e-14	7.9e-15	2.3e-14
2	PL	gene expression	LOC102546625	0.06	0.02	8.5e-07	0.06	0.05	0.06	0.06	3.5e-07	2.2e-06	5.3e-07	4.2e-07
3	PL	alternative polyA	XR_005486750.2	0.02	0.01	4.6e-03	0.01	0.01	0.01	0.01	2.6e-02	2.5e-02	5.9e-02	2.5e-02
4	PL	alternative polyA	XR_010053158.1	0.02	0.01	3.9e-03	0.01	0.01	0.01	0.01	2.4e-02	2.3e-02	4.7e-02	2.6e-02
5	NAcc	alternative polyA	XR_005486750.2	0.03	0.03	8.1e-03	0.02	0.01	0.01	0.01	9.1e-04	7.8e-03	2.3e-03	2.0e-03
6	PL	isoform ratio	XR_005486750.2	0.06	0.03	3.1e-03	0.01	0.01	0.01	0.01	1.0e-02	9.6e-03	1.9e-02	8.3e-03
7	OFC	alternative polyA	XR_010053158.1	0.1	0	3.2e-03	0	0.02	-0	-0.01	3.2e-01	9.0e-02	3.5e-01	5.0e-01
8	NAcc	isoform ratio	XR_005486750.2	0.06	0.04	7.7e-05	0.03	0.03	0.03	0.03	8.2e-06	2.3e-05	1.0e-05	2.7e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8
Bone: apparent density	1.1	2.0	6.7	0.6	1.2	0.7	-0.4	-1.3	1.0	-2.0	-2.6
Area under the delay curve	0.0	0.0	0.1	-0.2	0.1	-0.3	-0.0	0.3	-0.0	-0.2	-0.3
BMI with tail	6.8	23.6	31.5	5.6	5.2	5.5	-5.4	-5.2	5.1	-4.2	0.8
BMI without tail	0.7	4.0	5.7	2.3	2.1	2.4	-2.2	-2.0	2.1	-1.5	0.6
Body weight	0.6	2.5	3.6	1.9	1.7	1.9	-1.9	-1.6	1.5	-1.0	1.0
Weight adjusted by age	0.0	0.1	0.2	-0.2	-0.3	-0.3	0.2	0.2	-0.3	0.4	0.4
Bone surface	1.5	3.0	13.8	0.2	1.2	0.4	-0.2	-1.1	0.9	-2.5	-3.7
Bone volume	1.7	3.5	14.3	0.4	1.5	0.6	-0.3	-1.4	1.1	-2.7	-3.8
Breakpoint value in progressive ratio session	0.5	0.8	1.5	-0.9	-1.2	-0.8	1.1	0.8	-1.0	0.9	-0.1
Number of licking bursts	0.8	2.5	4.4	1.9	1.3	1.7	-1.8	-1.4	1.3	-0.4	2.1
Context. condit. distance diff. score	0.1	0.2	0.3	0.5	0.2	0.4	-0.5	-0.3	0.4	-0.1	0.6
Locomotion velocity, session 1	0.5	0.6	2.3	0.2	0.4	0.1	-0.2	-0.4	0.7	-1.1	-1.5
Locomotion distance, session 1	0.6	0.8	4.7	-0.2	0.1	-0.2	0.1	-0.2	0.2	-1.1	-2.2
Locomotion velocity, session 2	1.2	1.4	6.1	-1.1	-0.7	-1.1	1.1	0.6	-0.5	-0.5	-2.5
Locomotion distance, session 2	2.3	3.2	7.3	-2.1	-1.5	-2.0	2.0	1.5	-1.4	0.1	-2.7
Locomotion velocity, session 3	3.7	4.3	5.4	-2.3	-2.2	-2.3	2.3	2.2	-2.1	2.0	-0.0
Locomotion distance, session 3	0.2	0.2	0.4	-0.4	-0.6	-0.4	0.4	0.5	-0.4	0.4	-0.0
Stereotopy head waving bouts, day 3	3.6	4.3	6.1	-2.5	-2.2	-2.3	2.3	2.1	-2.4	1.3	-1.1
Stereotopy head waving duration, day 3	1.6	2.0	3.1	-1.7	-1.4	-1.6	1.5	1.4	-1.6	0.8	-0.9
Locomotion velocity, session 7	0.0	0.0	0.1	-0.0	-0.1	-0.1	-0.1	-0.0	-0.1	-0.3	-0.3
Locomotion distance, session 7	0.2	0.3	1.6	0.3	-0.1	0.2	-0.3	0.0	0.1	0.4	1.3
Stereotopy head waving bouts, day 7	0.5	0.5	2.2	-0.7	-0.3	-0.7	0.7	0.4	-0.4	-0.2	-1.5
Stereotopy head waving duration, day 7	0.6	0.7	3.2	-0.8	-0.2	-0.7	0.9	0.3	-0.5	-0.2	-1.8
Locomotion velocity, session 8	1.0	1.2	4.7	-1.1	-0.7	-1.1	1.1	0.7	-0.6	-0.3	-2.2
Locomotion distance, session 8	0.4	0.6	0.9	-0.9	-0.9	-0.9	0.9	0.8	-0.6	0.3	-0.7
Degree of sensitization distance	0.6	0.7	0.9	1.0	0.8	0.9	-0.9	-0.9	0.9	-0.6	0.6
Degree of sensitization stereotypy	0.4	0.5	1.1	0.4	0.8	0.4	-0.4	-0.7	0.7	-0.9	-1.0
Conditioned locomotion	0.5	0.6	2.0	0.8	0.5	0.7	-0.8	-0.4	0.6	0.2	1.4
Cocaine response after cond. corrected	1.8	2.6	3.9	2.0	1.5	1.8	-2.0	-1.5	1.6	-0.7	1.5
Cocaine response after cond. not corrected	1.8	2.5	3.8	2.0	1.5	1.9	-1.9	-1.6	1.5	-0.6	1.5
Cocaine response before conditioning	0.5	0.6	1.0	-0.9	-0.6	-0.7	1.0	0.5	-0.9	0.4	-0.8
Saline control response	0.1	0.1	0.3	0.4	0.2	0.4	-0.4	-0.2	0.3	-0.0	0.6
Bone: connectivity density	0.9	1.4	4.4	0.5	0.9	0.5	-0.4	-1.1	1.0	-1.6	-2.1
Bone: cortical apparent density	0.9	1.5	2.3	1.3	1.2	1.3	-1.2	-1.3	1.5	-1.2	-0.3
Bone: cortical area	1.7	2.7	4.3	1.4	1.9	1.4	-1.3	-1.8	1.5	-2.1	-1.5
Bone: cortical porosity	0.2	0.3	0.8	0.3	0.6	0.3	-0.1	-0.6	0.3	-0.6	-0.9
Bone: cortical porosity	0.8	0.9	1.5	0.7	1.1	0.7	-0.4	-1.1	0.8	-1.1	-1.2
Bone: cortical thickness	1.7	2.8	4.1	1.6	1.8	1.6	-1.4	-1.9	2.0	-1.8	-1.0
Bone: cortical thickness	0.3	0.3	0.6	0.7	0.5	0.6	-0.6	-0.5	0.8	-0.2	0.4
Bone: cortical tissue density	0.7	1.0	1.7	1.1	1.0	1.1	-1.0	-1.1	1.3	-1.0	-0.3
Condit. Reinf. active minus inactive responses	0.7	0.8	1.2	-1.0	-1.0	-1.1	1.1	0.8	-0.9	0.6	-0.6
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	0.3	0.2	0.3	-0.2	-0.3	0.0	-0.0	0.2
Condit. Reinf. active responses	1.8	2.3	3.5	-1.7	-1.5	-1.8	1.9	1.4	-1.4	0.9	-1.2
Condit. Reinf. inactive responses	2.2	2.8	4.0	-2.0	-1.7	-2.0	2.0	1.7	-1.6	1.0	-1.1
Incentive salience index mean	0.6	0.7	1.8	-0.9	-0.7	-1.0	1.0	0.6	-0.7	0.1	-1.4
Condit. Reinf. lever presses	0.5	0.7	4.2	-0.5	-0.1	-0.6	0.6	0.1	-0.1	-0.8	-2.1
Condit. Reinf. active minus inactive responses	1.8	2.8	3.7	-1.7	-1.8	-1.6	1.5	1.8	-1.9	1.9	0.9
Condit. Reinf. active-inactive response ratio	0.8	1.3	2.4	-0.8	-1.1	-0.7	0.6	1.1	-1.2	1.5	1.5
Condit. Reinf. active responses	1.3	1.8	2.3	-1.5	-1.4	-1.5	1.4	1.4	-1.5	1.4	0.3
Condit. Reinf. inactive responses	0.2	0.4	0.6	-0.7	-0.6	-0.7	0.8	0.5	-0.5	0.3	-0.4
Condit. Reinf. lever presses	2.9	4.3	5.3	-2.2	-2.3	-2.1	2.0	2.3	-2.3	2.2	0.7
Condit. Reinf. lever reinforcers received	1.3	1.8	2.1	-1.3	-1.4	-1.4	1.3	1.4	-1.5	1.5	0.6
Conditioned reinforcement - actives	0.1	0.3	1.0	0.7	0.4	0.7	-0.2	-1.0	0.4	-0.2	-0.0
Conditioned reinforcement - inactives	0.2	0.5	0.7	0.8	0.8	0.7	-0.8	-0.6	0.6	-0.2	0.7
Conditioned locomotion	0.7	1.0	2.0	-1.2	-1.0	-1.0	1.4	0.7	-1.1	0.7	-0.9
Patch foraging indifference point 0 sec	2.3	6.4	8.7	2.7	3.0	2.6	-2.7	-2.7	2.7	-2.5	-0.2
Patch foraging indifference point AUC	0.2	0.5	0.9	-0.7	-0.8	-0.7	0.6	0.8	-0.9	0.8	0.5
Delay disc. indifference point, 0s delay	1.9	2.1	4.1	1.1	1.6	1.0	-1.2	-1.3	1.6	-2.0	-1.5
Delay disc. indifference point, 16s delay	0.2	0.3	0.6	-0.7	-0.4	-0.8	0.5	0.8	-0.6	0.2	-0.4
Delay disc. indifference point, 2s delay	0.3	0.4	0.9	0.3	0.7	0.3	-0.5	-0.3	0.6	-0.9	-0.9
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	0.4	0.4	0.4	-0.4	-0.4	0.3	-0.3	-0.1
Delay disc. indifference point, 4s delay	0.4	0.4	1.5	-0.6	-0.3	-0.7	0.6	0.4	-0.3	-0.2	-1.2
Delay disc. indifference point, 8s delay	0.1	0.1	0.5	0.1	0.1	0.0	-0.3	0.2	-0.1	0.2	0.7
Indifference point function ln k	0.0	0.1	0.2	0.3	0.5	0.2	-0.4	-0.2	0.4	-0.4	-0.3
Indifference point function log k	0.0	0.1	0.2	0.3	0.5	0.2	-0.4	-0.2	0.4	-0.4	-0.3
Patch foraging total patch changes 0 sec	2.0	5.8	7.8	2.6	2.8	2.5	-2.5	-2.6	2.5	-2.4	-0.2
Patch foraging total patch changes 12 sec	1.4	1.8	2.7	1.6	1.4	1.5	-1.5	-1.4	1.4	-0.8	1.0
Patch foraging total patch changes 18 sec	0.0	0.1	0.1	0.2	0.3	0.3	-0.2	-0.3	0.1	-0.4	-0.2
Patch foraging total patch changes 24 sec	0.2	0.7	1.2	0.9	0.8	1.1	-0.7	-1.1	0.7	-0.9	-0.2
Patch foraging total patch changes 6 sec	1.8	3.0	4.0	2.0	1.8	1.9	-1.8	-2.0	1.8	-1.5	0.3
Patch foraging time to switch 0 sec	0.1	0.5	0.8	0.5	0.5	0.6	-0.4	-0.8	0.8	-0.8	-0.9
Patch foraging water rate 0 sec	0.1	0.5	1.3	0.9	0.7	0.7	-0.8	-0.5	0.5	-0.0	1.2
Patch foraging water rate 12 sec	0.3	1.0	1.5	1.2	1.0	1.1	-1.2	-1.0	0.9	-0.4	0.9
Patch foraging water rate 18 sec	0.5	1.1	5.6	0.1	-0.5	0.0	0.0	0.4	-0.7	1.5	2.4
Patch foraging water rate 24 sec	1.0	1.4	7.4	1.1	0.4	0.8	-1.1	-0.3	0.3	0.8	2.7
Patch foraging water rate 6 sec	0.6	0.8	2.0	-0.5	-0.7	-0.5	0.5	0.7	-1.1	1.3	1.4
Seeking ratio, delayed vs. immediate footshock	0.8	1.1	1.7	-1.3	-1.1	-1.0	1.2	1.1	-0.9	0.5	-0.9
Distance traveled before self-admin	0.6	1.3	1.9	-1.3	-1.3	-1.1	1.4	1.0	-1.3	1.0	-0.4
Distance traveled after self-admin	0.0	0.0	0.1	-0.2	-0.2	-0.2	0.1	0.4	-0.2	0.1	0.0
Extensor digitorum longus weight	3.7	14.7	20.6	4.5	3.9	4.4	-4.5	-3.9	4.0	-2.8	1.9
Bone: elastic displacement	0.0	0.0	0.1	-0.1	-0.0	-0.1	0.2	0.0	-0.1	-0.0	-0.3
Bone: elastic work	0.7	0.9	1.3	0.9	1.1	0.9	-0.7	-1.2	1.0	-1.1	-0.6
Bone: endosteal estimation	0.7	1.6	2.4	1.4	1.5	1.4	-1.6	-1.3	0.8	-1.5	-0.1
Bone: endosteal perimeter	0.2	0.4	2.2	-0.3	0.2	-0.2	0.1	-0.1	-0.4	-0.8	-1.5
Epididymis fat weight	0.1	0.4	1.2	-0.1	-0.5	0.0	0.3	0.2	-0.8	1.0	1.1
Delta time in closed arm before/after self-admin	1.2	1.1	4.9	1.0	0.5	0.9	-1.2	-0.2	0.5	0.3	2.2
Delta time in open arm before/after self-admin	0.4	0.4	0.6	0.8	0.8	0.7	-0.7	-0.7	0.7	-0.5	0.1
Diff in mean of infusions in LGA sessions	0.9	1.5	2.5	-1.3	-1.4	-1.2	1.5	1.0	-1.6	1.3	-0.0
Delay discount exponential model param	0.0	0.1	0.1	0.3	0.1	0.4	-0.1	-0.4	0.2	0.0	0.3
Extinction: sum of active levers before priming	1.1	1.6	2.7	-1.1	-1.6	-0.9	1.3	1.0	-1.5	1.6	0.8
Active lever presses in extinction session 6	0.1	0.1	0.2	-0.1	-0.4	-0.1	0.4	-0.2	-0.2	0.1	-0.5
Bone: final force	3.2	5.2	7.0	2.3	2.6	2.3	-2.2	-2.6	2.2	-2.5	-0.9
Bone: final moment	3.1	5.0	6.9	2.3	2.6	2.3	-2.1	-2.6	2.2	-2.4	-1.0
Food consumed during 24 hour testing period	0.0	0.1	0.2	0.3	0.3	0.3	-0.4	-0.3	0.1	-0.3	0.0
Glucose	1.2	1.8	2.8	1.6	1.3	1.7	-1.5	-1.5	1.3	-1.1	0.2
Heart weight	0.2	0.3	0.5	-0.4	-0.4	-0.3	0.4	0.4	-0.7	0.7	0.6
Delay discount hyperbolic model param	0.1	0.1	0.3	-0.0	-0.3	0.0	0.2	-0.0	-0.2	0.5	0.5
Intermittent access intake day 1-15 change	0.1	0.5	1.0	-0.4	-1.0	-0.2	0.6	0.3	-0.9	1.0	0.6
Intermittent access intake escalation	0.1	0.5	1.0	-0.4	-0.9	-0.3	0.6	0.4	-0.9	1.0	0.7
Intermittent access intake escalation 2	0.3	0.5	0.8	-0.7	-0.9	-0.6	0.7	0.6	-0.9	0.9	0.3
Intermitt. access day 1 inactive lever presses	0.1	1.4	2.4	-0.7	-1.2	-0.9	0.6	1.2	-1.3	1.5	1.5
Intermitt. access day 15 inactive lever presses	0.2	1.3	1.8	-1.2	-1.4	-1.2	1.2	1.1	-1.3	1.2	0.3
Intermitt. access escalation Index	0.1	0.2	0.8	-0.0	0.3	-0.1	-0.1	-0.0	0.5	-0.7	-0.9
Intermittent access day 1 total infusions	0.1	0.2	0.5	0.4	0.7	0.2	-0.6	-0.3	0.6	-0.2	0.5
Intermittent access day 15 total infusions	0.0	0.0	0.1	0.2	0.3	0.1	-0.2	-0.3	0.3	-0.1	0.0
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.3	0.1	0.3	0.0	0.0	-0.4	0.3	-0.4	-0.5
Intermittent access total infusions	0.3	0.3	0.6	0.6	0.7	0.5	-0.5	-0.7	0.7	-0.5	-0.1
Intermittent access day 1 locomotion	0.1	0.2	1.0	0.1	0.0	-0.2	-0.3	0.3	-0.0	0.4	1.0
Intermittent access day 15 total locomotion	0.1	0.2	0.3	-0.3	-0.4	-0.5	0.3	0.5	-0.4	0.6	0.5
Intermittent access total locomotion	0.1	0.1	0.2	-0.2	-0.2	-0.3	0.2	0.2	-0.3	0.4	0.3
Intermittent access standard deviation	0.1	0.4	0.9	-0.8	-0.5	-1.0	0.8	0.6	-0.6	0.3	-0.5
Left kidney weight	0.0	0.2	0.3	-0.4	-0.5	-0.3	0.3	0.5	-0.6	0.6	0.5
Right kidney weight	0.2	1.5	2.3	-1.2	-1.3	-1.1	1.2	1.2	-1.4	1.5	0.8
Cocaine induced anxiety	0.4	1.0	2.5	-1.1	-1.2	-0.7	1.4	0.5	-0.8	0.2	-1.6
Post-drug Anxiety	0.7	0.8	4.6	-0.4	-0.2	0.1	0.8	-0.3	-0.0	-0.7	-2.2
Baseline Anxiety	0.0	0.0	0.2	0.1	0.4	0.1	-0.2	-0.1	0.2	-0.2	-0.1
Tail length	3.0	16.0	19.6	-4.4	-4.3	-4.2	4.3	4.3	-4.3	3.9	0.3
Length with tail	2.0	8.9	11.1	-3.2	-3.1	-3.1	3.0	3.2	-3.3	3.2	0.9
Length without tail	0.1	0.4	0.8	0.7	0.8	0.6	-0.8	-0.5	0.5	-0.2	0.9
Times rat made contact with spout	0.9	1.0	1.5	1.2	0.9	1.1	-1.2	-1.0	0.7	-0.5	1.1
Lifetime Intake	1.1	1.3	1.9	1.2	1.4	1.1	-1.0	-1.4	1.3	-1.1	-0.2
Liver weight, left	0.1	0.2	0.4	0.6	0.5	0.6	-0.5	-0.6	0.4	-0.3	0.2
Liver weight, right	0.3	0.5	0.9	-0.6	-0.6	-0.6	0.5	0.7	-0.9	1.0	0.9
Locomotor activity	2.9	4.5	7.0	-2.5	-2.0	-2.4	2.7	1.9	-2.3	1.3	-1.5
Locomotor testing distance	0.7	1.8	2.9	-1.6	-1.2	-1.5	1.7	1.1	-1.4	0.7	-1.2
Locomotor testing rearing	0.0	0.2	0.3	-0.3	-0.5	-0.3	0.3	0.3	-0.6	0.5	0.5
Locomotion in novel chamber	0.1	0.1	0.2	0.4	0.1	0.3	-0.3	-0.3	0.3	-0.2	0.3
Locomotion in novel chamber post-restriction	1.4	4.1	5.7	-2.3	-2.2	-2.1	2.3	1.9	-2.4	1.8	-0.1
Fecal boli incidents, locomotor time 1	0.2	0.6	1.1	0.9	0.7	0.9	-0.9	-0.7	0.5	-0.1	1.0
Change in fecal boli incidents, locomotor task	0.5	0.6	1.8	-0.8	-0.5	-0.8	0.8	0.6	-0.2	-0.2	-1.3
Time >=10cm from walls, locomotor time 1	0.6	0.8	1.8	0.6	1.0	0.4	-0.7	-0.6	0.9	-1.3	-1.1
Bouts of movement, locomotor time 1	0.8	1.1	1.8	-1.1	-0.9	-1.3	0.9	1.3	-1.1	0.9	0.3
Total resting periods, locomotor time 1	1.6	1.8	2.7	-1.5	-1.3	-1.6	1.4	1.5	-1.5	1.2	0.1
Rest time, locomotor task time 1	0.3	0.5	0.8	-0.9	-0.7	-0.9	0.9	0.6	-0.8	0.3	-0.5
Distance moved, locomotor task time 1	0.6	1.7	2.4	1.1	1.2	1.3	-0.9	-1.5	1.4	-1.5	-1.2
Vertical activity count, locomotor time 1	0.2	1.7	2.6	1.6	1.1	1.6	-1.3	-1.5	1.4	-1.0	0.0
Time >=10cm from walls, locomotor time 2	0.2	0.6	1.3	0.9	0.9	0.7	-1.1	-0.3	0.9	-0.5	0.8
Bouts of movement, locomotor time 2	0.1	0.5	1.2	-0.7	-0.2	-1.1	0.5	0.7	-0.3	-0.3	-1.1
Total resting periods, locomotor time 2	0.1	0.5	1.8	-0.7	-0.1	-1.0	0.5	0.6	-0.2	-0.4	-1.3
Rest time, locomotor task time 2	0.1	0.2	0.9	-0.4	0.1	-0.4	0.3	0.2	-0.1	-0.4	-0.9
Distance moved, locomotor task time 2	0.1	0.1	0.8	0.2	-0.3	0.1	-0.0	0.0	-0.0	0.5	0.9
Vertical activity count, locomotor time 2	0.4	0.9	1.8	1.2	0.6	1.0	-1.1	-0.8	0.8	-0.1	1.3
Light reinforcement 1	1.2	5.7	8.4	-2.9	-2.3	-2.8	2.9	2.3	-2.4	1.6	-1.5
Light reinforcement 2	1.0	2.2	3.2	-1.8	-1.3	-1.8	1.7	1.6	-1.4	1.0	-1.0
Bone: marrow area	0.6	1.5	2.3	1.3	1.4	1.3	-1.5	-1.3	0.7	-1.4	-0.1
Bone: maximum diameter	0.3	0.6	3.5	-0.2	0.4	-0.1	0.2	-0.3	-0.4	-1.0	-1.9
Bone: maximum force	3.0	5.9	8.1	2.5	2.8	2.5	-2.3	-2.8	2.3	-2.6	-0.9
Bone: maximum moment	3.0	5.7	7.8	2.5	2.8	2.5	-2.3	-2.8	2.2	-2.6	-0.9
Mean time between licks in bursts	0.2	1.1	1.7	-1.1	-1.3	-1.1	0.9	1.2	-1.0	1.0	0.1
Mean num. licks in bursts	0.2	0.7	1.3	-0.9	-0.6	-0.9	0.9	0.7	-0.8	0.2	-1.2
Cd content in liver	0.0	0.0	0.1	-0.2	-0.3	-0.1	0.3	0.1	-0.2	0.1	0.0
Co content in liver	3.1	3.6	4.9	-2.1	-2.2	-2.0	2.1	1.9	-1.9	1.9	-0.2
Cu content in liver	0.7	0.9	2.0	0.7	0.9	0.7	-0.9	-0.8	0.9	-1.4	-0.9
Fe content in liver	0.2	0.3	0.8	0.6	0.3	0.5	-0.7	-0.4	0.5	-0.1	0.9
K content in liver	0.7	0.7	1.1	-1.0	-0.9	-1.0	1.0	0.9	-0.6	0.2	-0.9
Mg content in liver	1.0	1.1	1.6	-1.2	-1.1	-1.2	1.2	1.1	-1.0	0.7	-0.4
Mn content in liver	1.4	1.6	7.2	-1.1	-0.7	-1.1	1.1	0.7	-0.6	-0.6	-2.7
Na content in liver	0.5	0.6	1.2	0.7	0.7	0.7	-0.6	-0.8	0.7	-1.1	-0.7
Rb content in liver	0.5	0.6	1.4	0.4	0.8	0.5	-0.7	-0.5	0.7	-1.2	-0.9
Se content in liver	0.0	0.0	0.0	0.2	0.1	0.1	-0.2	-0.1	0.1	-0.1	0.2
Sr content in liver	0.4	0.4	0.9	-0.4	-0.6	-0.4	0.6	0.4	-0.5	1.0	0.9
Zn content in liver	3.7	4.4	6.7	-1.9	-2.3	-1.8	1.8	2.1	-2.3	2.6	1.8
Bone: minimum diameter	0.8	1.5	2.6	0.9	1.5	1.0	-0.9	-1.3	0.8	-1.6	-1.3
Time in familiar zone, hab. session 1	4.4	4.8	6.6	-2.3	-2.6	-2.2	2.1	2.4	-2.6	2.1	0.5
Time in novel zone, hab. session 1	3.6	4.0	5.3	1.9	2.3	1.9	-1.7	-2.2	2.3	-2.2	-1.2
Total zone transitions, hab. session 1	0.5	0.7	3.5	-0.6	-0.4	-0.6	0.6	0.3	-0.3	-0.6	-1.9
Total locomotion distance, hab. session 1	1.5	2.1	6.9	-1.5	-1.1	-1.5	1.5	1.0	-0.9	-0.3	-2.6
Locomotion velocity, hab. session 1	1.5	2.1	5.5	-1.6	-1.2	-1.6	1.5	1.2	-1.0	-0.1	-2.3
Time in familiar zone, hab. session 2	6.0	6.8	8.3	-2.7	-2.9	-2.6	2.8	2.7	-2.8	2.8	0.8
Time in novel zone, hab. session 2	7.2	7.9	10.0	2.9	3.2	2.8	-2.9	-3.0	3.0	-3.1	-1.1
Total zone transitions, hab. session 2	1.7	2.2	6.0	0.8	1.3	0.8	-0.7	-1.3	1.4	-2.1	-2.5
Total locomotion distance, hab. session 2	0.6	0.8	2.9	-0.9	-0.6	-0.9	0.9	0.6	-0.5	-0.3	-1.7
Locomotion velocity, hab. session 2	0.8	1.1	4.7	-0.9	-0.6	-1.0	0.9	0.6	-0.5	-0.5	-2.2
Novel to familiar place preference ratio	2.8	3.6	5.0	1.9	2.1	1.8	-1.8	-2.0	2.1	-2.2	-1.1
Novelty place preference	1.9	2.5	3.7	1.5	1.8	1.4	-1.5	-1.6	1.7	-1.9	-1.0
Time in novel zone, NPP test	2.6	3.2	4.3	1.8	2.0	1.7	-1.7	-1.9	2.0	-2.1	-0.9
Total zone transitions, NPP test	0.5	0.7	2.1	0.5	0.6	0.4	-0.4	-0.6	0.8	-1.2	-1.4
Total locomotion distance, NPP test	0.4	0.5	2.8	-0.1	0.2	-0.1	0.0	-0.1	0.4	-1.0	-1.7
Locomotion velocity, NPP test	0.3	0.5	2.7	-0.5	-0.2	-0.5	0.4	0.3	-0.0	-0.6	-1.6
Intraocular pressure	0.7	1.1	2.2	-0.8	-1.1	-0.8	0.7	1.1	-1.1	1.5	1.0
Delta distance traveled before/after self-admin	0.3	0.3	0.6	0.6	0.6	0.5	-0.8	-0.3	0.7	-0.4	0.4
Delta ambulatory time before/after self-admin	0.3	0.5	0.8	0.7	0.8	0.6	-0.8	-0.4	0.9	-0.8	-0.1
Parametrial fat weight	0.4	0.8	1.2	1.0	1.1	0.9	-1.0	-0.8	1.1	-1.0	-0.2
Pavlov. Cond. lever latency	0.5	0.6	3.2	-0.1	-0.5	-0.1	-0.1	0.5	-0.4	1.1	1.8
Pavlov. Cond. magazine entry latency	1.3	1.7	2.3	-1.5	-1.4	-1.5	1.5	1.4	-1.4	1.1	-0.3
Pavlov. Cond. change in total contacts	0.2	0.2	0.3	0.5	0.4	0.4	-0.4	-0.5	0.5	-0.4	0.0
Pavlov. Cond. index score	0.3	0.4	1.2	-0.7	-0.5	-0.7	0.8	0.4	-0.4	0.0	-1.1
Pavlov. Cond. latency score	0.4	0.5	2.1	-0.7	-0.3	-0.7	0.8	0.3	-0.3	-0.3	-1.5
Pavlov. Cond. lever contacts	0.5	0.7	2.9	0.2	0.6	0.2	-0.0	-0.7	0.6	-1.1	-1.7
Pavlov. Cond. magazine entry number	0.6	0.7	0.9	0.9	0.9	0.9	-1.0	-0.8	1.0	-0.8	-0.1
Pavlov. Cond. intertrial magazine entries	0.3	0.4	1.3	-0.3	-0.3	-0.3	0.3	0.4	-0.6	1.0	1.1
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.4	0.8	-0.7	-0.6	-0.8	0.9	0.5	-0.5	0.2	-0.9
Pavlov. Cond. response bias	0.4	0.4	0.7	-0.7	-0.7	-0.7	0.8	0.6	-0.7	0.6	-0.1
Pavlov. Cond. lever latency	2.2	3.1	4.2	2.0	1.9	1.9	-1.8	-2.0	1.9	-1.6	-0.1
Pavlov. Cond. magazine entry latency	2.6	3.7	4.9	-2.2	-2.1	-2.2	2.0	2.2	-2.1	1.7	-0.1
Pavlov. Cond. change in total contacts	0.7	1.8	2.5	-1.4	-1.5	-1.5	1.3	1.6	-1.4	1.3	0.2
Pavlov. Cond. index score	2.4	3.7	5.0	-2.1	-2.1	-2.1	1.9	2.2	-2.1	1.8	0.1
Pavlov. Cond. latency score	2.3	3.7	4.9	-2.2	-2.1	-2.1	2.0	2.2	-2.1	1.7	-0.1
Pavlov. Cond. lever contacts	2.1	3.1	4.2	-1.9	-1.9	-1.9	1.7	2.1	-1.9	1.7	0.4
Pavlov. Cond. magazine entry number	3.0	3.9	5.0	2.2	2.2	2.2	-2.1	-2.2	2.0	-1.8	0.1
Pavlov. Cond. intertrial magazine entries	0.7	1.6	2.3	1.5	1.2	1.5	-1.4	-1.4	1.2	-0.8	0.8
Pavlov. Cond. lever-magazine prob. diff.	2.5	3.8	5.1	-2.2	-2.2	-2.1	2.0	2.2	-2.1	1.8	-0.0
Pavlov. Cond. response bias	3.4	4.8	6.5	-2.3	-2.4	-2.3	2.1	2.5	-2.3	2.2	0.5
Time in closed arm before self-admin	0.2	0.3	1.2	0.1	0.6	0.2	-0.1	-0.3	0.5	-0.8	-1.1
Time in closed arm after self-admin	0.3	0.3	0.7	0.5	0.7	0.5	-0.8	-0.1	0.8	-0.6	0.3
Time in open arm before self-admin	0.1	0.1	0.3	0.4	0.1	0.3	-0.2	-0.5	0.1	-0.1	0.2
Time in open arm after self-admin	1.2	1.4	2.1	1.4	1.2	1.3	-1.3	-1.4	1.1	-0.7	0.7
Bone: periosteal estimation	1.3	3.2	5.1	1.7	2.1	1.7	-1.7	-1.9	1.4	-2.3	-1.2
Bone: periosteal perimeter	0.5	1.0	3.5	0.4	0.9	0.4	-0.4	-0.8	0.5	-1.4	-1.9
Bone: post-yield work	0.3	0.6	1.1	0.9	0.8	0.9	-1.0	-0.8	0.5	-0.6	0.4
Progressive ratio test 1 active lever presses	0.4	0.6	1.1	1.0	0.8	0.9	-0.8	-1.1	0.8	-0.5	0.4
Progressive ratio test 1 breakpoint	0.4	0.6	1.1	1.0	0.8	0.9	-0.8	-1.1	0.8	-0.4	0.4
Progressive ratio test 1 inactive lever presses	0.0	0.1	0.1	-0.2	-0.2	-0.3	0.4	-0.1	-0.2	0.2	-0.1
Progressive ratio test 2 active lever presses	0.0	0.0	0.0	0.0	-0.0	-0.2	0.1	-0.1	-0.0	0.0	-0.1
Progressive ratio test 2 breakpoint	0.0	0.0	0.1	-0.1	-0.1	-0.3	0.3	0.0	-0.2	0.1	-0.1
Progressive ratio test 2 inactive lever presses	0.2	0.6	1.4	0.7	0.7	0.7	-0.3	-1.2	0.7	-0.7	-0.7
Incentive Sensitization - Responses	0.2	0.5	1.0	-0.8	-0.7	-1.0	0.7	0.9	-0.7	0.6	0.0
Incentive Sensitization - Breakpoint	0.3	0.7	1.4	-0.9	-0.8	-1.2	0.9	1.1	-0.8	0.6	-0.2
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	-0.1	-0.3	0.1	0.3	-0.0	-0.4	0.3	0.1
Progressive ratio	0.3	0.9	1.7	1.1	0.9	0.7	-1.3	-0.5	1.1	-0.6	0.8
Food seeking constrained by brief footshock	1.6	2.0	2.9	-1.5	-1.6	-1.5	1.6	1.3	-1.7	1.4	-0.1
Seeking ratio, punishment vs. effort	1.2	2.7	4.1	-1.9	-1.8	-1.5	2.0	1.4	-2.0	1.5	-0.5
Retroperitoneal fat weight	1.4	6.3	9.5	3.1	2.4	2.9	-3.0	-2.4	2.5	-1.3	2.0
Reaction time number correct	0.2	0.8	2.8	0.9	0.6	0.7	-1.1	-0.4	0.6	-0.0	1.7
Reaction time mean minus median	0.3	1.7	2.2	-1.5	-1.4	-1.4	1.5	1.4	-1.4	1.0	-0.2
Reaction time mean minus median AUC	0.2	1.5	2.2	-1.5	-1.2	-1.4	1.4	1.2	-1.0	0.3	-1.3
Reaction time num false alarms	0.2	0.4	0.6	0.7	0.8	0.6	-0.7	-0.6	0.6	-0.5	0.2
Reaction time num false alarms AUC	0.1	0.3	0.5	0.7	0.7	0.6	-0.7	-0.6	0.5	-0.3	0.3
Reaction time trials correct on left	0.2	0.8	2.8	0.9	0.6	0.7	-1.1	-0.4	0.6	-0.0	1.7
Reaction time trials on left	0.2	0.8	2.6	0.9	0.6	0.7	-1.1	-0.4	0.6	-0.1	1.6
Reaction time mean	0.5	1.1	1.6	-1.3	-1.0	-1.2	1.1	1.1	-0.9	0.2	-1.2
Reaction time mean AUC	0.2	0.4	1.2	-0.7	-0.5	-0.7	0.6	0.6	-0.4	-0.2	-1.1
Median of all reaction times	0.4	0.6	1.5	-0.9	-0.6	-0.8	0.8	0.7	-0.6	-0.1	-1.2
Reaction time omissions	0.1	0.1	0.5	0.1	0.0	0.1	-0.1	-0.1	0.3	-0.5	-0.7
Reaction time false alarm rate	0.1	0.2	0.4	0.2	0.5	0.3	-0.1	-0.4	0.3	-0.4	-0.7
Reaction time premature initiation rate	1.6	2.5	3.5	-1.5	-1.6	-1.6	1.7	1.5	-1.8	1.9	0.7
Reaction time premature initiations	0.6	1.9	3.4	-1.0	-1.3	-1.2	1.0	1.3	-1.4	1.8	1.7
Std. dev. reaction times	0.2	0.7	0.9	-1.0	-0.9	-0.9	0.9	0.8	-0.8	0.3	-0.7
Reaction time trials completed	0.2	0.8	2.6	0.9	0.6	0.7	-1.1	-0.4	0.6	-0.1	1.6
Reaction time trials AUC	0.3	0.9	3.3	1.0	0.6	0.8	-1.1	-0.4	0.6	0.0	1.8
Run reversals in cocaine runway, females	2.0	2.2	3.6	-1.7	-1.4	-1.9	1.6	1.7	-1.3	0.8	-1.2
Run reversals in cocaine runway, males	1.1	1.2	1.9	-1.3	-1.0	-1.2	1.4	0.9	-0.9	0.5	-1.2
Latency to leave start box in cocaine runway	0.3	0.4	1.7	0.1	0.3	0.3	0.0	-0.4	0.5	-0.8	-1.3
Latency to leave start box in cocaine runway, F	0.8	0.9	3.0	0.3	0.9	0.4	-0.2	-0.8	1.0	-1.4	-1.7
Latency to leave start box in cocaine runway, M	0.2	0.2	0.4	-0.1	-0.6	-0.1	0.3	0.3	-0.4	0.6	0.5
Std. dev. time between licks in bursts	0.4	0.7	1.3	-1.0	-0.9	-1.0	0.8	0.8	-0.5	0.0	-1.2
Total sessions with >9 infusions	0.9	1.2	1.6	1.1	1.2	1.1	-1.0	-1.2	1.2	-1.1	-0.3
Short access day 1 total inactive lever presses	0.3	0.5	0.7	-0.8	-0.7	-0.8	0.6	0.9	-0.8	0.9	0.4
Short access day 10 total inactive lever presses	0.1	0.8	2.4	-0.4	-0.7	-0.6	0.1	1.0	-0.9	1.2	1.5
Short access day 1 total infusions	0.6	1.1	1.6	1.1	1.2	1.1	-1.0	-1.3	1.2	-1.1	-0.3
Short access day 10 total infusions	0.2	0.3	0.6	0.6	0.6	0.4	-0.6	-0.6	0.8	-0.4	0.2
Short access total infusions	1.1	1.5	2.3	1.2	1.5	1.1	-1.2	-1.3	1.5	-1.3	-0.3
Short access day 1 locomotion	0.2	0.3	0.4	-0.5	-0.6	-0.6	0.5	0.6	-0.7	0.6	0.3
Short access day 10 total locomotion	0.5	2.0	3.3	-1.2	-1.5	-1.4	1.1	1.4	-1.6	1.8	1.2
Short access total locomotion	0.1	0.2	0.4	-0.3	-0.5	-0.3	0.4	0.3	-0.5	0.6	0.5
One hour access (0.3 mA shock)	0.3	0.4	0.8	0.8	0.6	0.7	-0.5	-0.9	0.5	-0.2	0.4
Compulsive drug intake	0.0	0.1	0.2	-0.3	-0.1	-0.2	0.1	0.4	-0.2	-0.1	-0.4
One hour access (shock baseline)	0.0	0.1	0.3	0.3	0.0	0.2	0.0	-0.6	0.0	0.2	0.4
Social response proportion	1.0	1.2	2.1	-1.3	-1.2	-1.5	1.2	1.2	-0.9	0.8	-0.3
Social responses	7.5	9.8	13.7	-3.7	-3.2	-3.6	3.6	3.1	-3.4	2.2	-1.4
Social time	0.6	1.0	1.5	1.2	0.9	1.0	-1.2	-0.9	1.2	-0.7	0.7
Soleus weight	5.3	15.5	19.7	4.4	4.3	4.4	-4.1	-4.3	4.4	-3.5	0.1
Bone: stiffness	4.0	7.2	9.3	3.0	3.0	2.9	-2.9	-3.1	2.6	-2.6	-0.1
Tibialis anterior weight	1.4	4.9	6.4	2.5	2.4	2.5	-2.4	-2.4	2.2	-2.0	0.2
Time to tail flick, vehicle, before self-admin	0.6	0.7	1.3	-1.1	-0.7	-0.9	1.0	0.8	-0.6	0.2	-1.1
Time to tail flick, vehicle, after self-admin	0.5	0.9	1.7	-0.6	-0.9	-0.8	0.6	0.9	-1.0	1.3	1.3
Time to tail flick, test, before self-admin	0.6	0.7	1.7	-0.9	-0.7	-1.0	0.9	0.8	-0.4	-0.1	-1.3
Time to tail flick, test, after self-admin	0.1	0.1	0.4	0.1	0.5	0.2	-0.1	-0.3	0.2	-0.5	-0.6
Delta time to tail flick, vehicle, before/after SA	0.7	0.8	3.0	1.0	0.6	0.7	-1.0	-0.6	0.4	0.2	1.7
Delta time to tail flick, test, before/after SA	0.2	0.3	1.5	0.2	0.1	0.3	-0.2	-0.0	-0.4	0.6	1.2
Tibia length	1.2	3.4	5.2	-1.9	-1.9	-1.9	1.8	1.9	-2.3	1.9	0.4
Ambulatory time before self-admin	0.1	0.2	0.5	-0.5	-0.6	-0.3	0.7	0.2	-0.7	0.5	-0.2
Ambulatory time after self-admin	0.0	0.0	0.0	0.0	0.0	0.1	-0.0	-0.0	-0.0	-0.1	-0.1
Bone: tissue strength	6.3	6.6	8.7	2.8	2.9	2.9	-2.6	-3.0	2.5	-2.5	-0.1
Total heroin consumption	1.6	1.9	2.8	-1.6	-1.5	-1.5	1.7	1.3	-1.4	1.0	-0.8
Bone: trabecular number	0.4	0.7	4.3	-0.4	0.0	-0.3	0.6	-0.1	-0.1	-0.8	-2.1
Bone: trabecular spacing	0.6	0.9	4.9	0.1	-0.4	-0.0	-0.1	0.5	-0.3	1.3	2.2
Bone: trabecular thickness	1.7	2.3	9.2	0.4	1.2	0.5	-0.2	-1.2	1.1	-2.2	-3.0
Bone: trabecular tissue density	3.7	6.5	8.9	3.0	2.7	3.0	-2.9	-2.7	2.4	-1.7	1.4
Water consumed over 24 hours	0.4	0.8	1.5	0.8	1.0	0.8	-0.8	-1.0	0.8	-1.2	-0.8
Number of responses in last shaping day	1.2	1.5	2.8	-1.0	-1.7	-0.9	1.3	0.9	-1.6	1.5	0.4