Hub : Genes

LOC102546539

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	alternative polyA	XR_005494104.2	0.03	0.02	1.2e-03	0.03	0.01	0.02	0.02	3.0e-04	8.1e-03	4.3e-03	1.9e-03
2	Adipose	alternative polyA	XR_005494105.2	0.04	0.02	1.4e-03	0.03	0.01	0.01	0.02	3.2e-04	8.3e-03	1.5e-02	2.1e-03
3	Adipose	isoform ratio	XR_005494105.2	0.02	0.01	9.9e-03	0.01	0.01	0	0.01	6.7e-03	1.5e-02	1.3e-01	1.5e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.0	0.1	0.1	-0.3	0.3	0.3
Area under the delay curve	0.5	0.6	0.6	-0.7	0.7	0.7
BMI with tail	0.1	0.4	0.4	0.6	-0.6	-0.6
BMI without tail	0.1	0.2	0.2	0.4	-0.4	-0.4
Body weight	0.8	3.7	3.7	-1.9	1.9	1.9
Weight adjusted by age	1.5	2.2	2.2	1.5	-1.5	-1.5
Bone surface	0.1	0.2	0.2	-0.5	0.5	0.5
Bone volume	0.2	0.4	0.4	-0.6	0.6	0.6
Breakpoint value in progressive ratio session	0.0	0.0	0.0	-0.2	0.2	0.2
Number of licking bursts	0.7	1.2	1.2	-1.1	1.1	1.1
Context. condit. distance diff. score	0.0	0.0	0.0	0.1	-0.1	-0.1
Locomotion velocity, session 1	0.7	0.7	0.7	0.9	-0.9	-0.9
Locomotion distance, session 1	0.2	0.2	0.2	-0.4	0.4	0.4
Locomotion velocity, session 2	0.0	0.0	0.0	0.1	-0.1	-0.1
Locomotion distance, session 2	0.3	0.4	0.4	-0.6	0.6	0.6
Locomotion velocity, session 3	0.9	1.1	1.1	1.0	-1.0	-1.0
Locomotion distance, session 3	0.0	0.0	0.0	0.2	-0.2	-0.2
Stereotopy head waving bouts, day 3	0.6	0.7	0.7	0.8	-0.8	-0.8
Stereotopy head waving duration, day 3	0.3	0.3	0.3	0.6	-0.6	-0.6
Locomotion velocity, session 7	0.8	0.8	0.8	0.9	-0.9	-0.9
Locomotion distance, session 7	1.4	1.7	1.7	1.3	-1.3	-1.3
Stereotopy head waving bouts, day 7	0.8	0.9	0.9	-1.0	1.0	1.0
Stereotopy head waving duration, day 7	0.4	0.4	0.4	-0.7	0.7	0.7
Locomotion velocity, session 8	0.1	0.1	0.1	-0.3	0.3	0.3
Locomotion distance, session 8	1.0	1.4	1.4	-1.2	1.2	1.2
Degree of sensitization distance	1.5	1.5	1.5	1.2	-1.2	-1.2
Degree of sensitization stereotypy	1.6	1.8	1.8	-1.3	1.3	1.3
Conditioned locomotion	0.7	0.8	0.8	0.9	-0.9	-0.9
Cocaine response after cond. corrected	4.4	5.3	5.3	2.3	-2.3	-2.3
Cocaine response after cond. not corrected	2.0	2.4	2.4	1.5	-1.5	-1.5
Cocaine response before conditioning	3.7	4.4	4.4	-2.1	2.1	2.1
Saline control response	2.2	3.0	3.0	-1.7	1.7	1.7
Bone: connectivity density	0.3	0.5	0.5	-0.7	0.7	0.7
Bone: cortical apparent density	0.4	0.5	0.5	0.7	-0.7	-0.7
Bone: cortical area	0.0	0.0	0.0	-0.1	0.1	0.1
Bone: cortical porosity	3.9	4.3	4.3	-2.1	2.1	2.1
Bone: cortical porosity	3.4	3.7	3.7	-1.9	1.9	1.9
Bone: cortical thickness	0.2	0.3	0.3	-0.6	0.6	0.6
Bone: cortical thickness	0.5	0.6	0.6	0.8	-0.8	-0.8
Bone: cortical tissue density	0.3	0.4	0.4	0.7	-0.7	-0.7
Condit. Reinf. active minus inactive responses	0.2	0.2	0.2	-0.5	0.5	0.5
Condit. Reinf. active-inactive response ratio	1.0	1.1	1.1	1.0	-1.0	-1.0
Condit. Reinf. active responses	1.3	1.6	1.6	-1.3	1.3	1.3
Condit. Reinf. inactive responses	6.3	7.7	7.7	-2.8	2.8	2.8
Incentive salience index mean	2.5	3.1	3.1	-1.8	1.8	1.8
Condit. Reinf. lever presses	6.3	8.8	8.8	-3.0	3.0	3.0
Condit. Reinf. active minus inactive responses	0.1	0.1	0.1	0.4	-0.4	-0.4
Condit. Reinf. active-inactive response ratio	0.7	0.8	0.8	0.9	-0.9	-0.9
Condit. Reinf. active responses	0.0	0.0	0.0	0.0	-0.0	-0.0
Condit. Reinf. inactive responses	0.7	0.9	0.9	-1.0	1.0	1.0
Condit. Reinf. lever presses	0.9	1.3	1.3	-1.1	1.1	1.1
Condit. Reinf. lever reinforcers received	0.0	0.1	0.1	-0.2	0.2	0.2
Conditioned reinforcement - actives	0.4	0.7	0.7	0.8	-0.8	-0.8
Conditioned reinforcement - inactives	2.7	3.9	3.9	-2.0	2.0	2.0
Conditioned locomotion	0.0	0.0	0.0	0.1	-0.1	-0.1
Patch foraging indifference point 0 sec	5.1	9.5	9.5	-3.1	3.1	3.1
Patch foraging indifference point AUC	4.3	6.1	6.1	2.5	-2.5	-2.5
Delay disc. indifference point, 0s delay	0.1	0.1	0.1	-0.3	0.3	0.3
Delay disc. indifference point, 16s delay	0.5	0.6	0.6	-0.8	0.8	0.8
Delay disc. indifference point, 2s delay	0.7	0.8	0.8	0.9	-0.9	-0.9
Delay disc. indifference point, 24s delay	0.0	0.0	0.0	0.2	-0.2	-0.2
Delay disc. indifference point, 4s delay	0.5	0.6	0.6	0.7	-0.7	-0.7
Delay disc. indifference point, 8s delay	1.2	1.4	1.4	-1.2	1.2	1.2
Indifference point function ln k	4.6	8.1	8.1	-2.8	2.8	2.8
Indifference point function log k	4.6	8.1	8.1	-2.8	2.8	2.8
Patch foraging total patch changes 0 sec	5.0	9.4	9.4	-3.1	3.1	3.1
Patch foraging total patch changes 12 sec	0.8	1.0	1.0	-1.0	1.0	1.0
Patch foraging total patch changes 18 sec	0.3	0.4	0.4	-0.6	0.6	0.6
Patch foraging total patch changes 24 sec	1.2	2.0	2.0	-1.4	1.4	1.4
Patch foraging total patch changes 6 sec	1.5	2.3	2.3	-1.5	1.5	1.5
Patch foraging time to switch 0 sec	0.0	0.1	0.1	-0.3	0.3	0.3
Patch foraging water rate 0 sec	1.8	3.7	3.7	-1.9	1.9	1.9
Patch foraging water rate 12 sec	0.2	0.3	0.3	-0.6	0.6	0.6
Patch foraging water rate 18 sec	0.0	0.0	0.0	-0.2	0.2	0.2
Patch foraging water rate 24 sec	0.4	0.5	0.5	-0.7	0.7	0.7
Patch foraging water rate 6 sec	0.3	0.5	0.5	-0.7	0.7	0.7
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.2	0.5	-0.5	-0.5
Distance traveled before self-admin	0.3	0.4	0.4	0.6	-0.6	-0.6
Distance traveled after self-admin	2.4	3.0	3.0	1.7	-1.7	-1.7
Extensor digitorum longus weight	2.0	7.9	7.9	2.8	-2.8	-2.8
Bone: elastic displacement	0.5	0.6	0.6	-0.8	0.8	0.8
Bone: elastic work	1.4	1.8	1.8	-1.4	1.4	1.4
Bone: endosteal estimation	0.1	0.3	0.3	0.5	-0.5	-0.5
Bone: endosteal perimeter	0.2	0.4	0.4	0.6	-0.6	-0.6
Epididymis fat weight	0.5	1.6	1.6	-1.3	1.3	1.3
Delta time in closed arm before/after self-admin	0.0	0.0	0.0	-0.1	0.1	0.1
Delta time in open arm before/after self-admin	0.0	0.0	0.0	0.2	-0.2	-0.2
Diff in mean of infusions in LGA sessions	0.2	0.2	0.2	-0.5	0.5	0.5
Delay discount exponential model param	0.3	0.3	0.3	0.5	-0.5	-0.5
Extinction: sum of active levers before priming	0.9	0.9	0.9	-1.0	1.0	1.0
Active lever presses in extinction session 6	0.5	0.5	0.5	-0.7	0.7	0.7
Bone: final force	0.6	1.0	1.0	-1.0	1.0	1.0
Bone: final moment	0.8	1.2	1.2	-1.1	1.1	1.1
Food consumed during 24 hour testing period	0.0	0.1	0.1	-0.2	0.2	0.2
Glucose	0.3	0.4	0.4	0.6	-0.6	-0.6
Heart weight	0.0	0.0	0.0	-0.1	0.1	0.1
Delay discount hyperbolic model param	0.1	0.1	0.1	0.3	-0.3	-0.3
Intermittent access intake day 1-15 change	1.9	3.8	3.8	-1.9	1.9	1.9
Intermittent access intake escalation	2.2	4.5	4.5	-2.1	2.1	2.1
Intermittent access intake escalation 2	0.2	0.3	0.3	-0.5	0.5	0.5
Intermitt. access day 1 inactive lever presses	0.1	0.3	0.3	-0.5	0.5	0.5
Intermitt. access day 15 inactive lever presses	0.7	1.5	1.5	-1.2	1.2	1.2
Intermitt. access escalation Index	0.0	0.0	0.0	-0.0	0.0	0.0
Intermittent access day 1 total infusions	1.4	2.2	2.2	-1.5	1.5	1.5
Intermittent access day 15 total infusions	3.3	5.0	5.0	-2.2	2.2	2.2
Intermittent access terminal intake (last 3 days)	1.4	1.8	1.8	-1.4	1.4	1.4
Intermittent access total infusions	3.3	3.9	3.9	-2.0	2.0	2.0
Intermittent access day 1 locomotion	3.9	4.9	4.9	-2.2	2.2	2.2
Intermittent access day 15 total locomotion	0.3	0.6	0.6	-0.8	0.8	0.8
Intermittent access total locomotion	2.3	2.8	2.8	-1.7	1.7	1.7
Intermittent access standard deviation	0.2	0.5	0.5	-0.7	0.7	0.7
Left kidney weight	1.6	7.3	7.3	-2.7	2.7	2.7
Right kidney weight	2.3	10.6	10.6	-3.3	3.3	3.3
Cocaine induced anxiety	0.6	0.9	0.9	-0.9	0.9	0.9
Post-drug Anxiety	1.1	1.2	1.2	-1.1	1.1	1.1
Baseline Anxiety	0.0	0.0	0.0	-0.0	0.0	0.0
Tail length	1.2	4.7	4.7	-2.2	2.2	2.2
Length with tail	1.7	7.6	7.6	-2.8	2.8	2.8
Length without tail	0.2	0.7	0.7	-0.8	0.8	0.8
Times rat made contact with spout	2.2	2.5	2.5	-1.6	1.6	1.6
Lifetime Intake	2.8	3.4	3.4	-1.9	1.9	1.9
Liver weight, left	0.0	0.1	0.1	-0.2	0.2	0.2
Liver weight, right	0.1	0.1	0.1	-0.4	0.4	0.4
Locomotor activity	1.4	2.2	2.2	-1.5	1.5	1.5
Locomotor testing distance	2.6	4.6	4.6	-2.1	2.1	2.1
Locomotor testing rearing	3.0	6.0	6.0	-2.4	2.4	2.4
Locomotion in novel chamber	1.6	2.1	2.1	-1.4	1.4	1.4
Locomotion in novel chamber post-restriction	0.3	0.4	0.4	0.7	-0.7	-0.7
Fecal boli incidents, locomotor time 1	1.8	2.7	2.7	-1.6	1.6	1.6
Change in fecal boli incidents, locomotor task	2.3	2.3	2.3	1.5	-1.5	-1.5
Time >=10cm from walls, locomotor time 1	1.7	1.8	1.8	-1.3	1.3	1.3
Bouts of movement, locomotor time 1	0.4	0.5	0.5	0.7	-0.7	-0.7
Total resting periods, locomotor time 1	1.0	1.1	1.1	1.0	-1.0	-1.0
Rest time, locomotor task time 1	0.7	0.9	0.9	0.9	-0.9	-0.9
Distance moved, locomotor task time 1	0.1	0.2	0.2	-0.5	0.5	0.5
Vertical activity count, locomotor time 1	0.0	0.0	0.0	-0.0	0.0	0.0
Time >=10cm from walls, locomotor time 2	0.6	0.9	0.9	1.0	-1.0	-1.0
Bouts of movement, locomotor time 2	0.6	0.9	0.9	1.0	-1.0	-1.0
Total resting periods, locomotor time 2	0.2	0.4	0.4	0.6	-0.6	-0.6
Rest time, locomotor task time 2	0.0	0.0	0.0	0.1	-0.1	-0.1
Distance moved, locomotor task time 2	0.5	0.6	0.6	-0.8	0.8	0.8
Vertical activity count, locomotor time 2	0.1	0.1	0.1	0.3	-0.3	-0.3
Light reinforcement 1	0.5	1.2	1.2	-1.1	1.1	1.1
Light reinforcement 2	0.2	0.3	0.3	0.6	-0.6	-0.6
Bone: marrow area	0.1	0.2	0.2	0.4	-0.4	-0.4
Bone: maximum diameter	0.7	1.4	1.4	1.2	-1.2	-1.2
Bone: maximum force	0.3	0.5	0.5	-0.7	0.7	0.7
Bone: maximum moment	0.4	0.7	0.7	-0.8	0.8	0.8
Mean time between licks in bursts	0.0	0.0	0.0	-0.0	0.0	0.0
Mean num. licks in bursts	0.0	0.0	0.0	-0.0	0.0	0.0
Cd content in liver	0.1	0.1	0.1	-0.3	0.3	0.3
Co content in liver	3.3	3.9	3.9	2.0	-2.0	-2.0
Cu content in liver	0.4	0.5	0.5	0.7	-0.7	-0.7
Fe content in liver	0.0	0.0	0.0	0.0	-0.0	-0.0
K content in liver	0.4	0.4	0.4	-0.6	0.6	0.6
Mg content in liver	0.0	0.0	0.0	0.1	-0.1	-0.1
Mn content in liver	0.1	0.1	0.1	0.3	-0.3	-0.3
Na content in liver	3.0	3.2	3.2	-1.8	1.8	1.8
Rb content in liver	0.0	0.0	0.0	-0.1	0.1	0.1
Se content in liver	0.1	0.1	0.1	0.3	-0.3	-0.3
Sr content in liver	1.0	0.9	0.9	0.9	-0.9	-0.9
Zn content in liver	0.0	0.0	0.0	-0.1	0.1	0.1
Bone: minimum diameter	0.0	0.0	0.0	0.1	-0.1	-0.1
Time in familiar zone, hab. session 1	1.1	1.1	1.1	-1.0	1.0	1.0
Time in novel zone, hab. session 1	7.2	7.2	7.2	2.7	-2.7	-2.7
Total zone transitions, hab. session 1	0.3	0.4	0.4	0.6	-0.6	-0.6
Total locomotion distance, hab. session 1	0.0	0.1	0.1	0.3	-0.3	-0.3
Locomotion velocity, hab. session 1	0.6	0.8	0.8	-0.9	0.9	0.9
Time in familiar zone, hab. session 2	0.1	0.2	0.2	0.4	-0.4	-0.4
Time in novel zone, hab. session 2	0.1	0.1	0.1	0.3	-0.3	-0.3
Total zone transitions, hab. session 2	0.2	0.3	0.3	-0.6	0.6	0.6
Total locomotion distance, hab. session 2	0.2	0.2	0.2	-0.5	0.5	0.5
Locomotion velocity, hab. session 2	0.2	0.2	0.2	-0.5	0.5	0.5
Novel to familiar place preference ratio	0.7	0.8	0.8	-0.9	0.9	0.9
Novelty place preference	1.2	1.3	1.3	-1.2	1.2	1.2
Time in novel zone, NPP test	0.9	1.0	1.0	-1.0	1.0	1.0
Total zone transitions, NPP test	0.8	1.2	1.2	-1.1	1.1	1.1
Total locomotion distance, NPP test	1.7	2.3	2.3	-1.5	1.5	1.5
Locomotion velocity, NPP test	2.0	2.9	2.9	-1.7	1.7	1.7
Intraocular pressure	0.6	0.9	0.9	-0.9	0.9	0.9
Delta distance traveled before/after self-admin	2.7	2.8	2.8	1.7	-1.7	-1.7
Delta ambulatory time before/after self-admin	1.1	1.3	1.3	1.1	-1.1	-1.1
Parametrial fat weight	1.0	2.4	2.4	-1.5	1.5	1.5
Pavlov. Cond. lever latency	4.0	5.1	5.1	2.3	-2.3	-2.3
Pavlov. Cond. magazine entry latency	0.4	0.5	0.5	-0.7	0.7	0.7
Pavlov. Cond. change in total contacts	1.8	2.0	2.0	-1.4	1.4	1.4
Pavlov. Cond. index score	4.0	5.1	5.1	-2.3	2.3	2.3
Pavlov. Cond. latency score	4.3	5.5	5.5	-2.3	2.3	2.3
Pavlov. Cond. lever contacts	5.5	6.6	6.6	-2.6	2.6	2.6
Pavlov. Cond. magazine entry number	0.5	0.6	0.6	0.8	-0.8	-0.8
Pavlov. Cond. intertrial magazine entries	1.6	1.9	1.9	-1.4	1.4	1.4
Pavlov. Cond. lever-magazine prob. diff.	3.6	4.5	4.5	-2.1	2.1	2.1
Pavlov. Cond. response bias	1.1	1.4	1.4	-1.2	1.2	1.2
Pavlov. Cond. lever latency	0.9	1.3	1.3	1.1	-1.1	-1.1
Pavlov. Cond. magazine entry latency	1.9	2.3	2.3	-1.5	1.5	1.5
Pavlov. Cond. change in total contacts	0.1	0.1	0.1	0.4	-0.4	-0.4
Pavlov. Cond. index score	0.9	1.2	1.2	-1.1	1.1	1.1
Pavlov. Cond. latency score	0.9	1.2	1.2	-1.1	1.1	1.1
Pavlov. Cond. lever contacts	1.7	2.3	2.3	-1.5	1.5	1.5
Pavlov. Cond. magazine entry number	0.4	0.5	0.5	0.7	-0.7	-0.7
Pavlov. Cond. intertrial magazine entries	0.9	1.4	1.4	-1.2	1.2	1.2
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.7	0.7	-0.8	0.8	0.8
Pavlov. Cond. response bias	1.6	2.2	2.2	-1.5	1.5	1.5
Time in closed arm before self-admin	0.0	0.0	0.0	0.2	-0.2	-0.2
Time in closed arm after self-admin	0.0	0.0	0.0	0.0	-0.0	-0.0
Time in open arm before self-admin	0.3	0.4	0.4	0.6	-0.6	-0.6
Time in open arm after self-admin	0.5	0.5	0.5	0.7	-0.7	-0.7
Bone: periosteal estimation	0.1	0.3	0.3	0.5	-0.5	-0.5
Bone: periosteal perimeter	0.3	0.5	0.5	0.7	-0.7	-0.7
Bone: post-yield work	0.6	0.8	0.8	0.9	-0.9	-0.9
Progressive ratio test 1 active lever presses	0.1	0.1	0.1	-0.3	0.3	0.3
Progressive ratio test 1 breakpoint	0.0	0.0	0.0	-0.1	0.1	0.1
Progressive ratio test 1 inactive lever presses	1.4	2.0	2.0	-1.4	1.4	1.4
Progressive ratio test 2 active lever presses	0.4	0.5	0.5	-0.7	0.7	0.7
Progressive ratio test 2 breakpoint	0.5	0.6	0.6	-0.8	0.8	0.8
Progressive ratio test 2 inactive lever presses	1.5	2.4	2.4	-1.6	1.6	1.6
Incentive Sensitization - Responses	0.4	0.6	0.6	-0.8	0.8	0.8
Incentive Sensitization - Breakpoint	0.7	0.9	0.9	-1.0	1.0	1.0
Sum of active levers in priming session hrs 5-6	3.4	3.1	3.1	1.8	-1.8	-1.8
Progressive ratio	0.0	0.0	0.0	0.1	-0.1	-0.1
Food seeking constrained by brief footshock	5.6	6.8	6.8	2.6	-2.6	-2.6
Seeking ratio, punishment vs. effort	1.9	2.7	2.7	1.6	-1.6	-1.6
Retroperitoneal fat weight	0.1	0.6	0.6	-0.8	0.8	0.8
Reaction time number correct	2.3	4.5	4.5	2.1	-2.1	-2.1
Reaction time mean minus median	0.1	0.2	0.2	-0.4	0.4	0.4
Reaction time mean minus median AUC	0.0	0.0	0.0	0.0	-0.0	-0.0
Reaction time num false alarms	0.0	0.0	0.0	0.2	-0.2	-0.2
Reaction time num false alarms AUC	0.0	0.0	0.0	0.1	-0.1	-0.1
Reaction time trials correct on left	2.3	4.5	4.5	2.1	-2.1	-2.1
Reaction time trials on left	2.4	4.5	4.5	2.1	-2.1	-2.1
Reaction time mean	0.0	0.0	0.0	-0.1	0.1	0.1
Reaction time mean AUC	0.0	0.0	0.0	0.1	-0.1	-0.1
Median of all reaction times	0.0	0.0	0.0	0.2	-0.2	-0.2
Reaction time omissions	0.1	0.1	0.1	0.3	-0.3	-0.3
Reaction time false alarm rate	0.7	0.9	0.9	-1.0	1.0	1.0
Reaction time premature initiation rate	0.1	0.2	0.2	0.4	-0.4	-0.4
Reaction time premature initiations	1.6	2.8	2.8	1.7	-1.7	-1.7
Std. dev. reaction times	0.0	0.1	0.1	0.2	-0.2	-0.2
Reaction time trials completed	2.4	4.5	4.5	2.1	-2.1	-2.1
Reaction time trials AUC	2.3	4.4	4.4	2.1	-2.1	-2.1
Run reversals in cocaine runway, females	0.1	0.1	0.1	0.3	-0.3	-0.3
Run reversals in cocaine runway, males	1.7	1.7	1.7	-1.3	1.3	1.3
Latency to leave start box in cocaine runway	1.2	1.4	1.4	1.2	-1.2	-1.2
Latency to leave start box in cocaine runway, F	0.8	0.9	0.9	0.9	-0.9	-0.9
Latency to leave start box in cocaine runway, M	0.9	0.8	0.8	0.9	-0.9	-0.9
Std. dev. time between licks in bursts	0.1	0.1	0.1	-0.4	0.4	0.4
Total sessions with >9 infusions	0.9	1.1	1.1	-1.0	1.0	1.0
Short access day 1 total inactive lever presses	6.3	8.3	8.3	-2.9	2.9	2.9
Short access day 10 total inactive lever presses	0.4	1.0	1.0	-1.0	1.0	1.0
Short access day 1 total infusions	0.7	1.0	1.0	-1.0	1.0	1.0
Short access day 10 total infusions	1.3	1.6	1.6	-1.3	1.3	1.3
Short access total infusions	1.8	2.3	2.3	-1.5	1.5	1.5
Short access day 1 locomotion	1.0	1.2	1.2	-1.1	1.1	1.1
Short access day 10 total locomotion	0.5	0.9	0.9	-0.9	0.9	0.9
Short access total locomotion	1.8	2.2	2.2	-1.5	1.5	1.5
One hour access (0.3 mA shock)	3.4	3.9	3.9	-2.0	2.0	2.0
Compulsive drug intake	3.8	4.6	4.6	-2.1	2.1	2.1
One hour access (shock baseline)	0.0	0.0	0.0	-0.2	0.2	0.2
Social response proportion	3.2	3.6	3.6	1.9	-1.9	-1.9
Social responses	1.6	2.0	2.0	1.4	-1.4	-1.4
Social time	0.1	0.2	0.2	-0.4	0.4	0.4
Soleus weight	3.5	10.3	10.3	3.2	-3.2	-3.2
Bone: stiffness	0.3	0.5	0.5	-0.7	0.7	0.7
Tibialis anterior weight	0.5	1.7	1.7	1.3	-1.3	-1.3
Time to tail flick, vehicle, before self-admin	3.5	3.6	3.6	-1.9	1.9	1.9
Time to tail flick, vehicle, after self-admin	0.7	0.9	0.9	0.9	-0.9	-0.9
Time to tail flick, test, before self-admin	2.5	2.6	2.6	-1.6	1.6	1.6
Time to tail flick, test, after self-admin	0.1	0.1	0.1	0.3	-0.3	-0.3
Delta time to tail flick, vehicle, before/after SA	1.3	1.2	1.2	1.1	-1.1	-1.1
Delta time to tail flick, test, before/after SA	3.3	3.4	3.4	1.8	-1.8	-1.8
Tibia length	11.3	31.0	31.0	-5.6	5.6	5.6
Ambulatory time before self-admin	0.0	0.0	0.0	0.1	-0.1	-0.1
Ambulatory time after self-admin	1.5	1.8	1.8	1.3	-1.3	-1.3
Bone: tissue strength	0.1	0.1	0.1	0.3	-0.3	-0.3
Total heroin consumption	0.0	0.0	0.0	-0.2	0.2	0.2
Bone: trabecular number	0.0	0.1	0.1	-0.2	0.2	0.2
Bone: trabecular spacing	0.8	1.1	1.1	1.1	-1.1	-1.1
Bone: trabecular thickness	1.8	2.2	2.2	-1.5	1.5	1.5
Bone: trabecular tissue density	0.3	0.4	0.4	0.6	-0.6	-0.6
Water consumed over 24 hours	0.0	0.1	0.1	-0.3	0.3	0.3
Number of responses in last shaping day	0.2	0.2	0.2	0.5	-0.5	-0.5