LOC100912347

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	LOC100912347	0.04	0.02	1.0e-03	0.03	0.03	0.02	0.02	8.4e-04	1.8e-03	3.7e-03	2.6e-03
2	Liver	gene expression	LOC100912347	0.03	0.02	3.9e-04	0.02	0.01	0.02	0.02	1.9e-03	1.1e-02	2.5e-03	6.1e-03
3	LHb	gene expression	LOC100912347	0.18	0.1	1.5e-03	0.04	0.09	0.07	0.05	5.1e-02	3.4e-03	1.0e-02	2.1e-02
4	RMTg	gene expression	LOC100912347	0.13	0.08	7.8e-03	0.13	0.05	0.03	0.09	2.2e-04	1.8e-02	5.4e-02	2.4e-03
5	Adipose	gene expression	LOC100912347	0.03	0.02	3.3e-04	0.02	0.02	0.02	0.02	4.2e-03	3.0e-03	3.0e-03	6.2e-03
6	NAcc	gene expression	LOC100912347	0.02	0.01	1.0e-04	0.02	0.02	0.02	0.02	4.5e-04	2.4e-04	9.4e-04	5.4e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.0	0.1	0.2	-0.2	-0.2	0.1	0.2	-0.2	-0.4
Area under the delay curve	0.8	1.3	2.1	1.0	1.0	-1.5	1.5	-0.8	-0.9
BMI with tail	1.8	6.2	12.0	2.7	2.7	-3.5	2.6	-1.4	-1.3
BMI without tail	0.4	2.1	4.4	1.3	1.3	-2.1	2.0	-0.6	-0.8
Body weight	1.1	5.0	11.4	2.6	2.6	-3.4	2.1	-0.7	-0.5
Weight adjusted by age	0.9	2.5	3.6	1.6	1.6	-1.7	1.9	-1.6	-1.2
Bone surface	2.0	4.0	5.2	1.9	1.9	-1.6	2.1	-2.1	-2.3
Bone volume	0.9	1.7	2.3	1.2	1.2	-1.2	1.5	-1.3	-1.5
Breakpoint value in progressive ratio session	1.1	1.9	2.3	1.5	1.5	-1.2	1.2	-1.5	-1.4
Number of licking bursts	1.0	3.1	3.8	1.7	1.7	-1.8	1.7	-2.0	-1.8
Context. condit. distance diff. score	0.5	0.6	1.0	0.8	0.8	-0.8	0.2	-1.0	-0.7
Locomotion velocity, session 1	0.3	0.3	0.9	0.1	0.1	-0.9	0.9	-0.1	-0.4
Locomotion distance, session 1	0.2	0.3	0.6	-0.7	-0.7	0.6	0.0	0.2	-0.2
Locomotion velocity, session 2	0.8	1.0	2.6	0.5	0.5	-1.1	1.6	-0.7	-1.0
Locomotion distance, session 2	0.1	0.2	0.6	-0.4	-0.4	-0.1	0.8	0.4	-0.3
Locomotion velocity, session 3	0.8	0.9	3.0	-0.1	-0.1	0.1	1.1	-1.2	-1.7
Locomotion distance, session 3	0.9	1.0	2.4	-1.3	-1.3	1.6	-0.2	0.4	-0.3
Stereotopy head waving bouts, day 3	0.2	0.3	0.7	0.3	0.3	0.4	-0.8	-0.8	-0.2
Stereotopy head waving duration, day 3	0.3	0.3	0.7	0.6	0.6	-0.1	-0.8	-0.8	-0.2
Locomotion velocity, session 7	0.0	0.0	0.1	-0.1	-0.1	0.3	-0.0	-0.1	-0.1
Locomotion distance, session 7	0.3	0.3	0.8	0.4	0.4	-0.2	0.9	-0.5	-0.7
Stereotopy head waving bouts, day 7	0.6	0.7	2.5	0.3	0.3	-0.1	0.4	-1.2	-1.6
Stereotopy head waving duration, day 7	0.7	0.8	2.8	0.3	0.3	-0.3	0.7	-1.2	-1.7
Locomotion velocity, session 8	0.8	1.0	2.6	0.0	0.0	-0.7	1.5	-0.9	-1.6
Locomotion distance, session 8	0.6	0.9	1.9	0.4	0.4	-0.7	1.2	-1.0	-1.4
Degree of sensitization distance	1.1	1.2	2.2	1.5	1.5	-1.4	0.6	-0.6	-0.1
Degree of sensitization stereotypy	0.6	0.7	2.4	0.2	0.2	-0.2	0.8	-1.0	-1.5
Conditioned locomotion	0.9	1.0	2.2	-0.8	-0.8	0.6	-1.0	1.2	1.5
Cocaine response after cond. corrected	1.1	1.6	2.6	1.4	1.4	-1.6	0.9	-1.2	-1.1
Cocaine response after cond. not corrected	1.4	2.0	3.8	1.7	1.7	-1.9	0.7	-1.2	-0.8
Cocaine response before conditioning	0.8	1.0	2.0	1.2	1.2	-1.4	0.8	-0.6	-0.2
Saline control response	0.2	0.3	0.9	0.1	0.1	0.7	-0.9	-0.5	-0.3
Bone: connectivity density	0.4	0.7	1.5	-1.1	-1.1	1.2	-0.3	0.2	-0.2
Bone: cortical apparent density	2.7	4.3	4.7	-2.2	-2.2	2.0	-2.1	2.1	1.9
Bone: cortical area	0.3	0.5	1.2	1.1	1.1	0.0	-0.4	-0.6	-0.0
Bone: cortical porosity	0.3	0.3	0.6	-0.3	-0.3	0.7	-0.7	0.2	0.7
Bone: cortical porosity	0.2	0.3	0.7	-0.3	-0.3	0.8	-0.7	0.0	0.6
Bone: cortical thickness	2.2	3.7	6.9	-1.3	-1.3	2.2	-2.6	1.7	2.1
Bone: cortical thickness	0.7	0.9	1.9	-0.3	-0.3	0.7	-1.4	0.8	1.3
Bone: cortical tissue density	2.6	4.1	4.5	-2.1	-2.1	1.9	-2.0	2.0	1.8
Condit. Reinf. active minus inactive responses	0.4	0.5	1.2	-0.7	-0.7	-0.7	1.1	0.4	-0.3
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	0.1	0.1	-0.5	-0.1	0.1	0.1
Condit. Reinf. active responses	0.8	1.1	3.7	-0.5	-0.5	-1.0	1.9	-0.2	-1.1
Condit. Reinf. inactive responses	0.8	1.0	3.8	-0.1	-0.1	-0.6	1.9	-0.5	-1.2
Incentive salience index mean	0.9	1.2	3.5	0.2	0.2	-1.3	1.9	-0.8	-1.0
Condit. Reinf. lever presses	1.6	2.4	4.9	1.0	1.0	-1.4	2.2	-1.9	-1.3
Condit. Reinf. active minus inactive responses	1.0	1.5	2.4	1.1	1.1	-1.2	1.3	-1.0	-1.5
Condit. Reinf. active-inactive response ratio	0.3	0.4	0.9	0.6	0.6	-0.3	0.5	-0.7	-1.0
Condit. Reinf. active responses	1.4	2.0	3.3	1.4	1.4	-1.8	1.5	-0.8	-1.2
Condit. Reinf. inactive responses	0.6	0.8	2.2	0.9	0.9	-1.5	1.0	-0.3	-0.3
Condit. Reinf. lever presses	1.8	2.6	3.9	2.0	2.0	-1.6	0.8	-1.7	-1.4
Condit. Reinf. lever reinforcers received	1.1	1.6	2.7	1.3	1.3	-1.6	1.3	-0.7	-1.0
Conditioned reinforcement - actives	0.2	0.7	1.1	1.1	1.1	-0.7	0.4	-0.9	-0.4
Conditioned reinforcement - inactives	0.0	0.1	0.2	0.4	0.4	-0.3	0.1	-0.1	-0.1
Conditioned locomotion	0.4	0.6	1.5	-0.4	-0.4	0.4	-0.9	0.9	1.2
Patch foraging indifference point 0 sec	0.1	0.4	0.8	0.5	0.5	-0.5	0.4	-0.7	-0.9
Patch foraging indifference point AUC	0.4	1.0	1.5	-1.2	-1.2	0.5	-0.5	1.2	1.0
Delay disc. indifference point, 0s delay	0.2	0.2	0.4	-0.6	-0.6	-0.2	0.5	0.4	-0.4
Delay disc. indifference point, 16s delay	0.0	0.1	0.2	0.1	0.1	-0.1	-0.0	0.3	0.5
Delay disc. indifference point, 2s delay	0.4	0.4	1.0	0.5	0.5	-1.0	0.9	-0.2	-0.4
Delay disc. indifference point, 24s delay	0.1	0.1	0.4	0.1	0.1	-0.3	0.7	-0.0	-0.1
Delay disc. indifference point, 4s delay	0.9	1.0	1.9	0.7	0.7	-1.2	1.4	-0.8	-1.1
Delay disc. indifference point, 8s delay	2.0	3.4	5.6	1.7	1.7	-2.4	2.1	-1.4	-1.5
Indifference point function ln k	0.5	1.5	1.9	1.3	1.3	-0.8	1.0	-1.4	-1.4
Indifference point function log k	0.5	1.5	1.9	1.3	1.3	-0.8	1.0	-1.4	-1.4
Patch foraging total patch changes 0 sec	0.0	0.1	0.3	0.3	0.3	-0.4	0.1	-0.4	-0.5
Patch foraging total patch changes 12 sec	0.7	1.0	1.1	-1.0	-1.0	0.9	-1.0	1.0	0.9
Patch foraging total patch changes 18 sec	0.2	0.5	1.3	-0.5	-0.5	0.5	-1.1	0.5	0.7
Patch foraging total patch changes 24 sec	0.2	0.5	1.1	-1.1	-1.1	0.2	-0.4	0.9	0.0
Patch foraging total patch changes 6 sec	0.3	0.5	1.3	-1.1	-1.1	0.5	-0.1	0.6	-0.2
Patch foraging time to switch 0 sec	0.1	0.3	0.9	-0.3	-0.3	1.0	-0.8	0.0	0.3
Patch foraging water rate 0 sec	0.3	1.0	2.5	0.8	0.8	-1.6	1.0	-0.5	-0.8
Patch foraging water rate 12 sec	0.5	2.1	3.0	1.1	1.1	-1.7	1.7	-1.1	-1.7
Patch foraging water rate 18 sec	0.2	0.4	1.4	-0.7	-0.7	0.1	-0.1	1.2	0.5
Patch foraging water rate 24 sec	0.2	0.2	0.5	-0.7	-0.7	0.1	0.3	0.4	-0.2
Patch foraging water rate 6 sec	1.4	2.0	2.7	1.3	1.3	-1.6	1.5	-1.2	-1.7
Seeking ratio, delayed vs. immediate footshock	4.9	7.0	7.7	2.8	2.8	-2.6	2.7	-2.5	-2.5
Distance traveled before self-admin	1.2	2.5	4.1	1.3	1.3	-1.4	1.7	-1.8	-2.0
Distance traveled after self-admin	2.4	4.3	4.9	2.2	2.2	-2.0	1.9	-2.2	-1.9
Extensor digitorum longus weight	1.1	4.2	5.7	2.1	2.1	-2.4	2.4	-1.3	-1.9
Bone: elastic displacement	0.9	1.1	2.1	-1.0	-1.0	0.7	-0.8	1.4	1.2
Bone: elastic work	0.5	0.7	0.9	-0.8	-0.8	0.6	-1.0	0.9	0.8
Bone: endosteal estimation	4.7	11.4	12.8	3.5	3.5	-3.2	3.2	-3.6	-3.2
Bone: endosteal perimeter	2.7	6.6	7.6	2.8	2.8	-2.4	2.5	-2.6	-2.3
Epididymis fat weight	1.7	8.5	11.4	-3.4	-3.4	2.6	-2.3	3.1	2.5
Delta time in closed arm before/after self-admin	1.6	1.5	2.4	-1.0	-1.0	1.0	-1.4	1.4	1.6
Delta time in open arm before/after self-admin	0.4	0.4	1.4	-0.4	-0.4	1.2	-0.5	-0.4	-0.7
Diff in mean of infusions in LGA sessions	1.9	3.4	4.5	2.1	2.1	-1.9	1.5	-1.8	-1.3
Delay discount exponential model param	1.2	1.7	2.8	-1.1	-1.1	1.6	-1.7	0.9	1.1
Extinction: sum of active levers before priming	0.4	0.6	0.9	0.9	0.9	-0.5	0.5	-1.0	-0.7
Active lever presses in extinction session 6	2.0	2.0	3.0	1.2	1.2	-1.3	1.4	-1.5	-1.7
Bone: final force	0.2	0.4	0.5	0.7	0.7	-0.6	0.6	-0.5	-0.3
Bone: final moment	0.0	0.1	0.1	0.3	0.3	-0.2	0.0	-0.2	0.1
Food consumed during 24 hour testing period	3.1	6.1	8.8	3.0	3.0	-2.8	1.9	-2.3	-1.6
Glucose	0.1	0.2	0.5	-0.7	-0.7	0.2	0.3	0.1	-0.1
Heart weight	0.4	0.7	2.0	0.5	0.5	-1.1	1.4	-0.1	-0.7
Delay discount hyperbolic model param	1.2	1.6	2.6	-1.1	-1.1	1.6	-1.6	0.9	1.0
Intermittent access intake day 1-15 change	0.2	1.3	2.6	1.2	1.2	-1.6	1.1	-0.8	-0.9
Intermittent access intake escalation	0.2	1.2	2.3	1.1	1.1	-1.5	1.1	-0.7	-0.8
Intermittent access intake escalation 2	1.9	3.3	4.9	1.7	1.7	-2.2	1.9	-1.5	-1.7
Intermitt. access day 1 inactive lever presses	0.1	0.7	1.3	-0.6	-0.6	0.8	-1.1	0.7	1.2
Intermitt. access day 15 inactive lever presses	0.2	1.0	1.6	-1.1	-1.1	0.6	-0.7	1.2	1.1
Intermitt. access escalation Index	0.1	0.3	1.2	0.3	0.3	-1.1	0.3	-0.3	-0.0
Intermittent access day 1 total infusions	0.1	0.3	0.8	-0.2	-0.2	0.7	-0.6	0.3	0.9
Intermittent access day 15 total infusions	0.0	0.1	0.1	0.4	0.4	-0.2	0.0	-0.2	0.2
Intermittent access terminal intake (last 3 days)	0.3	0.6	1.1	1.1	1.1	-0.8	0.2	-0.6	-0.1
Intermittent access total infusions	0.1	0.2	0.3	0.5	0.5	-0.1	-0.2	-0.5	0.2
Intermittent access day 1 locomotion	0.6	1.2	2.7	-0.8	-0.8	1.0	-1.0	1.2	1.6
Intermittent access day 15 total locomotion	0.1	0.4	1.1	-0.0	-0.0	0.5	-0.9	0.5	1.0
Intermittent access total locomotion	0.3	0.3	0.8	0.9	0.9	-0.4	0.0	-0.4	0.1
Intermittent access standard deviation	0.0	0.1	0.1	0.4	0.4	-0.4	-0.0	-0.1	0.2
Left kidney weight	0.1	1.1	2.7	1.3	1.3	-1.7	0.5	-0.2	0.1
Right kidney weight	0.1	0.7	1.8	1.0	1.0	-1.3	0.5	-0.1	-0.1
Cocaine induced anxiety	0.0	0.0	0.1	0.1	0.1	0.1	-0.0	-0.4	-0.1
Post-drug Anxiety	0.1	0.1	0.3	-0.4	-0.4	0.5	-0.4	0.0	-0.1
Baseline Anxiety	0.7	1.2	1.8	-1.3	-1.3	1.1	-0.9	1.3	0.4
Tail length	0.1	0.3	0.7	-0.6	-0.6	-0.0	0.4	0.8	0.4
Length with tail	0.1	0.3	0.8	0.3	0.3	-0.9	0.4	0.6	0.2
Length without tail	0.6	3.2	7.5	2.0	2.0	-2.7	1.5	-0.8	-0.8
Times rat made contact with spout	1.6	1.9	2.7	1.5	1.5	-1.6	1.2	-1.3	-0.8
Lifetime Intake	0.1	0.1	0.1	0.3	0.3	0.2	-0.3	-0.4	0.3
Liver weight, left	0.1	0.2	0.6	0.5	0.5	-0.8	0.5	0.1	0.1
Liver weight, right	0.4	0.6	1.5	0.7	0.7	-1.2	1.1	0.1	0.0
Locomotor activity	0.0	0.1	0.3	0.1	0.1	-0.5	0.2	-0.2	-0.0
Locomotor testing distance	0.0	0.0	0.1	-0.0	-0.0	-0.3	-0.2	-0.2	-0.2
Locomotor testing rearing	0.0	0.1	0.1	-0.4	-0.4	-0.2	-0.4	0.1	-0.1
Locomotion in novel chamber	0.0	0.0	0.1	0.2	0.2	0.0	-0.0	-0.4	-0.1
Locomotion in novel chamber post-restriction	0.2	0.5	0.9	-0.5	-0.5	0.6	-0.9	0.9	0.7
Fecal boli incidents, locomotor time 1	0.4	1.1	2.2	1.0	1.0	-1.5	1.2	-0.8	-0.4
Change in fecal boli incidents, locomotor task	0.7	0.7	1.6	0.7	0.7	0.1	-0.0	-1.3	-1.3
Time >=10cm from walls, locomotor time 1	0.8	0.9	1.3	1.0	1.0	-0.8	1.0	-1.1	-0.9
Bouts of movement, locomotor time 1	0.2	0.2	0.6	0.4	0.4	-0.5	0.8	0.1	0.1
Total resting periods, locomotor time 1	0.2	0.2	0.5	0.4	0.4	-0.5	0.7	-0.0	0.0
Rest time, locomotor task time 1	0.3	0.5	1.2	0.8	0.8	-1.1	0.2	0.1	0.4
Distance moved, locomotor task time 1	0.3	0.9	1.8	-1.3	-1.3	0.9	-0.3	0.8	0.3
Vertical activity count, locomotor time 1	0.1	0.5	0.9	-1.0	-1.0	0.7	-0.4	0.5	0.2
Time >=10cm from walls, locomotor time 2	0.0	0.1	0.5	0.1	0.1	0.0	-0.4	0.2	0.7
Bouts of movement, locomotor time 2	0.3	1.1	2.0	-1.2	-1.2	0.6	-0.4	1.4	1.1
Total resting periods, locomotor time 2	0.2	0.7	1.4	-1.0	-1.0	0.5	-0.3	1.2	0.9
Rest time, locomotor task time 2	0.8	1.4	2.1	-0.9	-0.9	1.1	-1.5	1.1	1.4
Distance moved, locomotor task time 2	0.2	0.3	1.0	-0.3	-0.3	-0.3	1.0	-0.1	-0.8
Vertical activity count, locomotor time 2	0.1	0.2	0.3	0.2	0.2	-0.5	0.6	-0.3	-0.4
Light reinforcement 1	0.5	2.2	5.0	1.2	1.2	-2.2	2.1	-0.6	-0.7
Light reinforcement 2	0.1	0.2	0.4	0.4	0.4	0.2	-0.5	-0.6	0.4
Bone: marrow area	4.6	11.4	12.8	3.5	3.5	-3.2	3.1	-3.6	-3.2
Bone: maximum diameter	6.3	12.6	17.4	4.2	4.2	-3.4	2.9	-3.5	-2.9
Bone: maximum force	0.4	0.8	1.1	1.1	1.1	-0.8	0.8	-1.0	-0.7
Bone: maximum moment	0.2	0.3	0.5	0.7	0.7	-0.5	0.2	-0.7	-0.3
Mean time between licks in bursts	0.0	0.3	0.7	-0.1	-0.1	0.5	-0.9	0.3	0.8
Mean num. licks in bursts	0.3	0.9	1.7	-0.7	-0.7	0.6	-0.9	1.2	1.3
Cd content in liver	1.8	2.0	4.5	-1.6	-1.6	0.8	-0.4	2.1	1.1
Co content in liver	1.1	1.3	3.1	-0.9	-0.9	0.3	-0.6	1.8	1.7
Cu content in liver	0.0	0.1	0.2	0.2	0.2	-0.2	-0.4	0.1	0.3
Fe content in liver	4.5	5.6	9.7	2.3	2.3	-1.2	2.1	-2.8	-3.1
K content in liver	0.0	0.0	0.1	0.2	0.2	0.0	-0.4	0.0	-0.1
Mg content in liver	0.4	0.5	0.7	0.6	0.6	-0.8	0.6	-0.6	-0.8
Mn content in liver	0.2	0.2	0.4	0.3	0.3	0.4	-0.7	-0.6	0.4
Na content in liver	1.8	2.0	3.7	1.2	1.2	-0.8	1.3	-1.8	-1.9
Rb content in liver	1.2	1.4	2.4	1.2	1.2	-0.7	1.3	-1.0	-1.6
Se content in liver	0.2	0.2	0.7	0.0	0.0	0.9	-0.7	-0.3	-0.2
Sr content in liver	0.0	0.0	0.0	-0.2	-0.2	0.0	0.1	-0.2	-0.1
Zn content in liver	1.4	1.6	2.3	-1.0	-1.0	1.1	-1.4	1.5	1.5
Bone: minimum diameter	0.2	0.4	1.2	1.1	1.1	-0.4	0.2	-0.4	0.2
Time in familiar zone, hab. session 1	1.8	2.0	2.6	1.3	1.3	-1.4	1.6	-1.6	-1.3
Time in novel zone, hab. session 1	1.8	2.0	3.1	-1.3	-1.3	0.9	-1.8	1.7	1.4
Total zone transitions, hab. session 1	1.3	1.8	3.5	-1.9	-1.9	1.3	-0.3	1.3	0.6
Total locomotion distance, hab. session 1	2.5	3.5	6.6	-2.6	-2.6	1.7	-0.7	1.8	0.9
Locomotion velocity, hab. session 1	1.4	2.0	4.0	-2.0	-2.0	1.4	-0.4	1.2	0.6
Time in familiar zone, hab. session 2	0.2	0.2	0.3	0.3	0.3	-0.4	0.6	-0.4	-0.5
Time in novel zone, hab. session 2	0.1	0.1	0.3	-0.0	-0.0	0.1	-0.5	0.0	0.3
Total zone transitions, hab. session 2	0.6	0.8	1.7	-1.3	-1.3	0.4	0.6	0.8	0.0
Total locomotion distance, hab. session 2	1.2	1.5	3.3	-1.8	-1.8	0.8	0.2	1.2	0.5
Locomotion velocity, hab. session 2	1.4	1.9	3.9	-2.0	-2.0	1.1	-0.1	1.3	0.8
Novel to familiar place preference ratio	0.2	0.3	0.6	0.6	0.6	-0.8	0.4	-0.4	-0.3
Novelty place preference	0.6	0.7	1.4	0.9	0.9	-1.2	0.8	-0.7	-0.5
Time in novel zone, NPP test	1.0	1.2	2.2	1.2	1.2	-1.5	1.0	-0.9	-0.7
Total zone transitions, NPP test	0.2	0.3	0.8	-0.5	-0.5	0.0	0.9	0.3	-0.5
Total locomotion distance, NPP test	0.3	0.4	0.8	-0.8	-0.8	0.2	0.9	0.4	-0.3
Locomotion velocity, NPP test	0.5	0.7	1.4	-1.2	-1.2	0.7	0.5	0.6	-0.1
Intraocular pressure	0.1	0.1	0.4	0.3	0.3	-0.3	-0.4	0.6	0.2
Delta distance traveled before/after self-admin	0.2	0.3	0.4	0.7	0.7	-0.7	0.2	0.1	0.5
Delta ambulatory time before/after self-admin	0.2	0.3	0.7	0.8	0.8	-0.6	0.1	-0.0	0.5
Parametrial fat weight	1.5	3.5	4.1	-1.9	-1.9	1.6	-1.7	2.0	2.0
Pavlov. Cond. lever latency	2.0	2.5	4.3	-1.3	-1.3	1.5	-2.1	1.7	1.5
Pavlov. Cond. magazine entry latency	0.1	0.1	0.3	-0.4	-0.4	0.1	0.6	-0.1	0.4
Pavlov. Cond. change in total contacts	0.1	0.1	0.4	-0.1	-0.1	-0.3	0.6	-0.1	0.2
Pavlov. Cond. index score	0.2	0.3	1.3	0.1	0.1	-0.4	1.2	-0.6	-0.2
Pavlov. Cond. latency score	0.3	0.4	1.5	0.2	0.2	-0.5	1.2	-0.7	-0.4
Pavlov. Cond. lever contacts	1.1	1.3	2.8	0.9	0.9	-1.1	1.7	-1.2	-0.8
Pavlov. Cond. magazine entry number	0.2	0.2	0.4	0.6	0.6	-0.2	-0.5	-0.1	-0.4
Pavlov. Cond. intertrial magazine entries	0.4	0.5	2.0	-0.2	-0.2	-0.5	0.8	-0.3	-1.4
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	1.5	0.1	0.1	-0.4	1.2	-0.7	-0.3
Pavlov. Cond. response bias	0.2	0.3	1.2	0.1	0.1	-0.4	1.1	-0.4	-0.1
Pavlov. Cond. lever latency	2.9	4.0	4.4	-2.1	-2.1	2.1	-1.8	2.0	1.9
Pavlov. Cond. magazine entry latency	0.3	0.5	1.5	-0.4	-0.4	1.2	-1.0	-0.0	0.4
Pavlov. Cond. change in total contacts	0.2	0.6	0.9	1.0	1.0	-0.6	0.6	-0.7	-0.7
Pavlov. Cond. index score	0.7	1.1	1.8	1.2	1.2	-0.7	0.7	-1.3	-1.1
Pavlov. Cond. latency score	1.1	1.7	2.7	1.5	1.5	-0.9	0.9	-1.7	-1.4
Pavlov. Cond. lever contacts	2.7	4.0	4.5	2.1	2.1	-2.0	1.8	-2.0	-1.9
Pavlov. Cond. magazine entry number	0.2	0.2	0.7	-0.2	-0.2	-0.5	-0.1	0.8	0.6
Pavlov. Cond. intertrial magazine entries	0.1	0.3	0.7	0.5	0.5	-0.8	0.7	-0.0	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.6	1.0	1.6	1.1	1.1	-0.6	0.7	-1.3	-1.0
Pavlov. Cond. response bias	0.6	0.8	1.2	0.9	0.9	-0.7	0.8	-1.1	-1.1
Time in closed arm before self-admin	1.2	2.0	2.7	1.3	1.3	-1.2	1.6	-1.6	-1.4
Time in closed arm after self-admin	0.3	0.4	0.5	-0.7	-0.7	0.5	-0.3	0.6	0.7
Time in open arm before self-admin	0.6	0.8	1.4	1.1	1.1	-1.2	0.4	-0.5	-0.1
Time in open arm after self-admin	1.6	1.8	3.5	1.3	1.3	-0.6	0.7	-1.9	-1.6
Bone: periosteal estimation	3.1	7.4	10.2	3.2	3.2	-2.5	2.2	-2.8	-2.3
Bone: periosteal perimeter	1.6	3.2	4.5	2.1	2.1	-1.4	1.4	-2.0	-1.7
Bone: post-yield work	2.8	4.8	6.2	1.9	1.9	-2.2	2.2	-2.5	-2.5
Progressive ratio test 1 active lever presses	0.1	0.1	0.3	0.4	0.4	-0.1	-0.1	-0.2	0.5
Progressive ratio test 1 breakpoint	0.1	0.2	0.3	0.6	0.6	-0.2	-0.2	-0.4	0.5
Progressive ratio test 1 inactive lever presses	0.1	0.2	0.7	-0.2	-0.2	0.3	-0.8	0.3	0.8
Progressive ratio test 2 active lever presses	0.1	0.2	0.3	0.6	0.6	-0.4	0.1	-0.4	0.2
Progressive ratio test 2 breakpoint	0.1	0.1	0.2	0.4	0.4	-0.3	0.1	-0.3	0.2
Progressive ratio test 2 inactive lever presses	0.1	0.3	0.7	-0.3	-0.3	0.5	-0.8	0.2	0.7
Incentive Sensitization - Responses	0.0	0.1	0.1	0.4	0.4	-0.3	-0.1	-0.2	0.2
Incentive Sensitization - Breakpoint	0.0	0.0	0.2	0.0	0.0	-0.2	-0.2	0.1	0.4
Sum of active levers in priming session hrs 5-6	1.3	1.2	1.6	1.3	1.3	-0.9	0.8	-1.1	-1.3
Progressive ratio	0.1	0.4	1.1	0.6	0.6	-1.0	0.3	-0.5	-0.2
Food seeking constrained by brief footshock	4.3	5.4	7.5	2.3	2.3	-2.7	2.2	-2.1	-2.4
Seeking ratio, punishment vs. effort	0.5	1.1	2.2	0.8	0.8	-0.7	1.3	-0.9	-1.5
Retroperitoneal fat weight	2.5	11.3	16.0	-3.7	-3.7	2.7	-2.7	4.0	3.3
Reaction time number correct	0.2	0.7	1.6	0.3	0.3	-0.3	1.3	-0.8	-1.2
Reaction time mean minus median	0.2	1.6	1.9	-1.0	-1.0	1.3	-1.3	1.4	1.4
Reaction time mean minus median AUC	0.1	0.9	1.4	-0.7	-0.7	1.2	-1.1	0.9	0.9
Reaction time num false alarms	0.8	1.3	1.7	-1.3	-1.3	1.3	-1.3	0.9	0.6
Reaction time num false alarms AUC	0.6	1.4	2.0	-1.4	-1.4	1.4	-1.2	0.9	0.5
Reaction time trials correct on left	0.2	0.7	1.6	0.3	0.3	-0.3	1.3	-0.8	-1.2
Reaction time trials on left	0.2	0.6	1.4	0.2	0.2	-0.1	1.2	-0.8	-1.2
Reaction time mean	0.5	1.2	2.1	-0.8	-0.8	1.3	-1.4	0.9	1.2
Reaction time mean AUC	0.3	0.7	1.1	-0.6	-0.6	1.0	-1.0	0.6	0.9
Median of all reaction times	0.7	1.1	1.9	-0.7	-0.7	1.2	-1.4	0.7	1.2
Reaction time omissions	2.4	3.9	5.7	-2.3	-2.3	2.4	-1.6	1.7	1.3
Reaction time false alarm rate	1.6	2.2	3.0	-1.6	-1.6	1.4	-1.7	1.4	1.2
Reaction time premature initiation rate	0.0	0.1	0.2	-0.0	-0.0	-0.3	0.2	0.5	0.2
Reaction time premature initiations	0.1	0.2	0.6	0.2	0.2	-0.4	0.8	0.1	-0.4
Std. dev. reaction times	0.6	2.0	2.8	-1.3	-1.3	1.7	-1.5	1.3	1.4
Reaction time trials completed	0.2	0.6	1.4	0.2	0.2	-0.1	1.2	-0.8	-1.2
Reaction time trials AUC	0.2	0.7	1.7	0.3	0.3	-0.3	1.2	-0.9	-1.3
Run reversals in cocaine runway, females	1.2	1.4	1.9	-1.3	-1.3	1.0	-1.4	1.0	1.1
Run reversals in cocaine runway, males	1.0	1.1	2.5	0.6	0.6	-1.1	1.6	-0.8	-1.3
Latency to leave start box in cocaine runway	0.3	0.3	0.8	0.4	0.4	-0.1	0.5	-0.9	-0.8
Latency to leave start box in cocaine runway, F	0.1	0.1	0.2	0.1	0.1	-0.2	0.5	-0.3	-0.3
Latency to leave start box in cocaine runway, M	0.2	0.2	0.6	0.4	0.4	0.2	-0.1	-0.8	-0.7
Std. dev. time between licks in bursts	0.5	1.0	1.4	0.8	0.8	-0.7	1.2	-1.1	-1.1
Total sessions with >9 infusions	0.2	0.3	0.5	0.7	0.7	-0.4	0.3	-0.6	0.0
Short access day 1 total inactive lever presses	0.2	0.4	1.2	-0.1	-0.1	0.0	-0.9	0.5	1.1
Short access day 10 total inactive lever presses	0.0	0.2	0.5	-0.4	-0.4	0.1	-0.7	0.5	0.5
Short access day 1 total infusions	0.0	0.1	0.1	0.4	0.4	-0.1	-0.1	-0.4	0.1
Short access day 10 total infusions	0.2	0.3	0.4	0.4	0.4	0.7	-0.6	-0.6	0.3
Short access total infusions	0.2	0.3	0.6	-0.2	-0.2	0.8	-0.7	-0.0	0.7
Short access day 1 locomotion	0.4	0.6	0.9	0.9	0.9	-0.9	0.9	-0.3	-0.1
Short access day 10 total locomotion	0.2	0.8	1.7	1.3	1.3	-0.4	0.4	-0.9	-0.5
Short access total locomotion	0.2	0.3	0.6	0.8	0.8	-0.2	-0.0	-0.4	0.4
One hour access (0.3 mA shock)	0.1	0.1	0.2	0.2	0.2	0.1	-0.4	-0.0	0.4
Compulsive drug intake	0.2	0.3	0.5	0.6	0.6	0.1	-0.5	-0.7	-0.3
One hour access (shock baseline)	0.0	0.0	0.0	0.0	0.0	0.0	0.2	-0.2	0.1
Social response proportion	0.6	0.7	1.3	-0.7	-0.7	0.9	-0.9	0.7	1.1
Social responses	0.0	0.1	0.2	-0.3	-0.3	-0.0	0.1	0.0	0.4
Social time	0.1	0.1	0.2	-0.5	-0.5	0.1	-0.1	-0.2	-0.1
Soleus weight	7.3	21.6	28.2	4.3	4.3	-5.2	5.3	-4.1	-4.5
Bone: stiffness	0.1	0.2	0.5	0.4	0.4	-0.2	0.6	-0.4	-0.7
Tibialis anterior weight	4.5	15.5	16.4	4.0	4.0	-4.0	4.1	-3.6	-4.0
Time to tail flick, vehicle, before self-admin	0.0	0.1	0.1	-0.3	-0.3	0.3	-0.2	0.2	-0.1
Time to tail flick, vehicle, after self-admin	0.9	1.8	3.0	1.6	1.6	-1.0	0.7	-1.7	-1.3
Time to tail flick, test, before self-admin	0.4	0.4	1.0	-0.6	-0.6	0.2	-0.5	1.0	0.8
Time to tail flick, test, after self-admin	0.4	0.4	1.4	0.6	0.6	-1.2	0.5	-0.3	-0.2
Delta time to tail flick, vehicle, before/after SA	1.8	1.9	2.6	1.4	1.4	-1.1	1.3	-1.6	-1.5
Delta time to tail flick, test, before/after SA	1.0	1.2	1.7	1.3	1.3	-1.1	0.6	-1.3	-0.9
Tibia length	1.1	3.0	6.5	2.6	2.6	-1.7	0.4	-1.3	0.0
Ambulatory time before self-admin	0.4	1.2	2.3	0.7	0.7	-0.8	1.2	-1.4	-1.5
Ambulatory time after self-admin	2.3	3.8	4.6	2.2	2.2	-1.8	1.7	-2.1	-1.7
Bone: tissue strength	0.7	0.7	1.0	-1.0	-1.0	0.8	-0.9	0.6	0.6
Total heroin consumption	1.5	1.8	2.4	1.6	1.6	-1.5	1.3	-1.0	-1.1
Bone: trabecular number	0.1	0.2	0.4	-0.3	-0.3	0.3	0.5	-0.5	-0.6
Bone: trabecular spacing	2.1	3.1	4.4	-1.6	-1.6	1.5	-1.8	2.1	1.9
Bone: trabecular thickness	0.1	0.1	0.3	0.0	0.0	-0.1	-0.5	0.1	0.4
Bone: trabecular tissue density	0.3	0.5	1.3	0.2	0.2	0.2	-1.1	0.7	0.9
Water consumed over 24 hours	1.7	3.3	4.3	2.1	2.1	-2.0	1.7	-1.7	-1.3
Number of responses in last shaping day	2.1	2.7	4.2	1.8	1.8	-2.1	1.5	-1.6	-0.9