Hub : Genes

LOC100912347

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	LOC100912347	0.03	0.02	4.0e-03	0	0.02	0.01	0.01	2.3e-01	5.9e-03	1.8e-02	5.5e-02
2	LHb	gene expression	LOC100912347	0.17	0.1	5.1e-03	0.03	0.05	0.02	0.02	8.3e-02	2.8e-02	1.2e-01	1.3e-01
3	Liver	gene expression	LOC100912347	0.03	0.02	4.2e-04	0.02	0.01	0.02	0.01	2.9e-03	1.6e-02	3.6e-03	7.7e-03
4	NAcc	gene expression	LOC100912347	0.02	0.01	8.9e-03	0	0.01	0.01	0	1.5e-01	5.3e-02	3.7e-02	8.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.0	0.1	0.2	0.0	0.1	0.1	0.5
Area under the delay curve	1.7	1.8	2.9	-1.6	-1.7	1.2	0.6
BMI with tail	2.1	6.7	11.3	-3.1	-3.4	2.5	0.0
BMI without tail	0.8	1.6	3.1	-1.5	-1.8	0.9	0.6
Body weight	1.7	7.0	12.8	-3.1	-3.6	2.3	-0.4
Weight adjusted by age	2.2	2.5	3.6	-1.8	-1.9	1.6	0.8
Bone surface	1.9	3.4	4.1	-1.7	-1.6	2.0	2.0
Bone volume	0.9	1.5	1.7	-1.2	-1.2	1.3	1.2
Breakpoint value in progressive ratio session	1.3	1.4	1.9	-1.2	-1.2	1.4	0.9
Number of licking bursts	2.3	2.7	3.2	-1.8	-1.7	1.7	1.4
Context. condit. distance diff. score	0.5	0.6	0.9	-0.8	-0.7	1.0	0.6
Locomotion velocity, session 1	0.5	0.5	1.0	-0.9	-1.0	0.4	0.3
Locomotion distance, session 1	0.4	0.5	0.9	0.6	0.6	-0.9	0.6
Locomotion velocity, session 2	0.7	0.9	1.2	-1.1	-1.1	0.4	1.0
Locomotion distance, session 2	0.2	0.3	0.6	0.0	-0.2	-0.8	0.7
Locomotion velocity, session 3	1.2	1.4	5.5	-0.0	0.3	0.1	2.3
Locomotion distance, session 3	1.8	2.0	2.6	1.4	1.6	-1.4	1.2
Stereotopy head waving bouts, day 3	0.2	0.2	0.4	0.3	0.6	0.6	-0.0
Stereotopy head waving duration, day 3	0.2	0.3	1.0	-0.2	0.0	1.0	-0.2
Locomotion velocity, session 7	0.1	0.1	0.2	0.3	0.3	-0.3	0.4
Locomotion distance, session 7	0.2	0.3	0.8	-0.3	-0.2	0.4	0.9
Stereotopy head waving bouts, day 7	0.9	1.1	4.0	-0.3	0.1	0.4	2.0
Stereotopy head waving duration, day 7	1.1	1.3	4.6	-0.6	-0.3	0.5	2.1
Locomotion velocity, session 8	1.2	1.4	4.4	-0.8	-0.7	0.3	2.1
Locomotion distance, session 8	0.6	0.9	2.7	-0.7	-0.7	0.2	1.6
Degree of sensitization distance	1.6	1.6	2.4	-1.3	-1.4	1.5	-0.5
Degree of sensitization stereotypy	1.0	1.1	3.9	-0.4	-0.2	0.3	2.0
Conditioned locomotion	0.8	1.0	2.5	0.7	0.5	-0.8	-1.6
Cocaine response after cond. corrected	1.8	2.0	2.9	-1.7	-1.6	1.5	0.5
Cocaine response after cond. not corrected	2.5	2.8	3.8	-1.9	-1.9	1.9	-0.1
Cocaine response before conditioning	1.0	1.2	2.0	-1.2	-1.4	1.0	-0.5
Saline control response	0.1	0.2	0.4	0.3	0.6	0.4	0.4
Bone: connectivity density	0.7	1.1	1.7	1.2	1.3	-0.8	0.7
Bone: cortical apparent density	2.8	3.7	5.1	1.9	1.8	-2.3	-1.7
Bone: cortical area	0.2	0.3	1.1	-0.3	-0.2	1.0	-0.3
Bone: cortical porosity	0.4	0.5	0.8	0.7	0.7	-0.3	-0.9
Bone: cortical porosity	0.6	0.6	1.0	1.0	1.0	-0.4	-0.5
Bone: cortical thickness	1.6	2.7	3.3	1.8	1.8	-1.2	-1.8
Bone: cortical thickness	0.8	1.0	2.5	0.7	0.7	-0.5	-1.6
Bone: cortical tissue density	2.6	3.4	4.8	1.8	1.7	-2.2	-1.6
Condit. Reinf. active minus inactive responses	0.4	0.4	0.7	-0.6	-0.9	-0.5	0.6
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.4	-0.6	-0.7	0.2	-0.3
Condit. Reinf. active responses	0.9	1.1	2.2	-1.0	-1.1	-0.2	1.5
Condit. Reinf. inactive responses	0.7	0.8	2.6	-0.5	-0.6	-0.0	1.6
Incentive salience index mean	0.9	1.1	1.8	-1.2	-1.3	0.5	1.0
Condit. Reinf. lever presses	1.1	1.4	1.9	-1.2	-1.2	1.4	1.0
Condit. Reinf. active minus inactive responses	1.4	1.7	2.1	-1.4	-1.3	1.2	1.4
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.9	-0.6	-0.3	0.6	0.9
Condit. Reinf. active responses	1.8	2.4	3.6	-1.9	-1.9	1.4	0.9
Condit. Reinf. inactive responses	0.9	1.1	2.3	-1.2	-1.5	0.7	-0.1
Condit. Reinf. lever presses	1.7	2.3	3.4	-1.7	-1.5	1.8	0.9
Condit. Reinf. lever reinforcers received	1.4	2.0	3.1	-1.7	-1.8	1.2	0.6
Conditioned reinforcement - actives	0.1	0.1	0.1	0.3	0.3	-0.1	0.2
Conditioned reinforcement - inactives	0.0	0.0	0.0	0.2	0.1	-0.2	-0.2
Conditioned locomotion	1.0	1.2	3.4	0.8	0.6	-0.6	-1.8
Patch foraging indifference point 0 sec	0.2	0.3	0.5	-0.5	-0.4	0.3	0.7
Patch foraging indifference point AUC	0.7	0.8	1.4	0.8	0.6	-1.2	-0.9
Delay disc. indifference point, 0s delay	0.3	0.3	0.7	-0.4	-0.5	-0.3	0.8
Delay disc. indifference point, 16s delay	0.1	0.1	0.1	-0.2	-0.2	0.3	-0.3
Delay disc. indifference point, 2s delay	0.5	0.6	1.2	-0.9	-1.1	0.4	0.2
Delay disc. indifference point, 24s delay	0.0	0.0	0.1	-0.2	-0.2	0.0	0.0
Delay disc. indifference point, 4s delay	1.5	1.5	1.9	-1.4	-1.4	0.9	1.3
Delay disc. indifference point, 8s delay	3.6	3.7	5.8	-2.3	-2.4	1.7	1.0
Indifference point function ln k	0.8	1.2	1.8	-1.1	-0.8	1.0	1.3
Indifference point function log k	0.8	1.2	1.8	-1.1	-0.8	1.0	1.3
Patch foraging total patch changes 0 sec	0.1	0.1	0.2	-0.4	-0.4	0.2	0.3
Patch foraging total patch changes 12 sec	0.8	1.0	1.2	1.0	0.9	-1.1	-1.0
Patch foraging total patch changes 18 sec	0.2	0.3	0.6	0.5	0.5	-0.3	-0.8
Patch foraging total patch changes 24 sec	0.3	0.4	1.3	0.2	0.1	-1.1	0.3
Patch foraging total patch changes 6 sec	0.3	0.4	0.8	0.5	0.4	-0.9	0.6
Patch foraging time to switch 0 sec	0.4	0.6	1.4	1.1	1.2	-0.3	-0.1
Patch foraging water rate 0 sec	1.2	1.9	3.3	-1.8	-1.8	1.0	0.3
Patch foraging water rate 12 sec	1.8	2.7	3.6	-1.9	-1.8	1.1	1.6
Patch foraging water rate 18 sec	0.1	0.2	0.4	-0.1	-0.2	-0.7	-0.4
Patch foraging water rate 24 sec	0.0	0.1	0.2	-0.1	-0.0	-0.3	0.4
Patch foraging water rate 6 sec	1.9	2.7	3.3	-1.8	-1.8	1.4	1.6
Seeking ratio, delayed vs. immediate footshock	5.4	6.3	6.6	-2.5	-2.4	2.5	2.6
Distance traveled before self-admin	1.8	1.9	2.6	-1.2	-1.0	1.6	1.6
Distance traveled after self-admin	3.5	3.9	5.1	-2.1	-2.1	2.3	1.4
Extensor digitorum longus weight	1.1	4.2	6.1	-2.3	-2.5	1.6	1.7
Bone: elastic displacement	0.4	0.4	0.7	0.5	0.4	-0.7	-0.9
Bone: elastic work	0.2	0.2	0.4	0.4	0.4	-0.3	-0.6
Bone: endosteal estimation	4.5	9.9	12.6	-3.3	-3.2	3.6	2.3
Bone: endosteal perimeter	2.5	5.3	6.9	-2.5	-2.4	2.6	1.5
Epididymis fat weight	3.7	8.6	12.5	2.9	2.5	-3.5	-2.6
Delta time in closed arm before/after self-admin	1.1	1.1	2.9	0.8	0.7	-0.7	-1.7
Delta time in open arm before/after self-admin	1.8	1.8	3.2	1.4	1.8	-0.8	1.1
Diff in mean of infusions in LGA sessions	2.7	3.0	4.9	-1.8	-1.7	2.2	0.9
Delay discount exponential model param	2.0	2.1	3.4	1.7	1.8	-1.2	-0.8
Extinction: sum of active levers before priming	0.2	0.2	0.5	0.1	0.3	0.7	0.3
Active lever presses in extinction session 6	0.8	0.8	1.6	-0.8	-0.7	0.8	1.3
Bone: final force	0.2	0.4	0.6	-0.7	-0.7	0.8	0.1
Bone: final moment	0.1	0.2	0.3	-0.4	-0.4	0.5	-0.4
Food consumed during 24 hour testing period	5.3	6.4	9.2	-2.9	-2.8	3.0	0.5
Glucose	0.3	0.5	1.0	0.7	0.8	-1.0	-0.0
Heart weight	0.1	0.1	0.2	-0.3	-0.5	-0.2	-0.3
Delay discount hyperbolic model param	1.8	1.9	3.0	1.6	1.7	-1.2	-0.8
Intermittent access intake day 1-15 change	0.1	0.1	0.1	-0.3	-0.4	0.3	0.1
Intermittent access intake escalation	0.8	0.8	1.1	-1.0	-1.1	1.0	0.4
Intermittent access intake escalation 2	1.8	1.7	2.0	-1.4	-1.4	1.4	1.1
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.2	0.2	0.2	-0.1	-0.5
Intermitt. access day 15 inactive lever presses	1.3	1.4	3.1	0.9	0.6	-1.1	-1.8
Intermitt. access escalation Index	2.3	2.1	3.6	-1.8	-1.9	1.1	-0.5
Intermittent access day 1 total infusions	2.4	2.8	3.1	1.8	1.7	-1.4	-1.7
Intermittent access day 15 total infusions	0.4	0.5	1.1	0.6	0.5	-0.4	-1.1
Intermittent access terminal intake (last 3 days)	0.2	0.2	0.7	0.0	-0.1	0.3	-0.8
Intermittent access total infusions	0.8	0.8	1.3	0.9	1.0	-0.4	-1.2
Intermittent access day 1 locomotion	3.4	3.6	4.7	1.9	1.8	-1.7	-2.2
Intermittent access day 15 total locomotion	0.9	0.9	1.5	1.0	0.9	-0.5	-1.2
Intermittent access total locomotion	0.2	0.2	0.5	0.5	0.5	-0.0	-0.7
Intermittent access standard deviation	0.2	0.2	0.3	-0.1	-0.2	0.6	-0.6
Left kidney weight	0.3	0.7	1.4	-1.0	-1.2	0.6	-0.4
Right kidney weight	0.2	0.7	1.2	-0.9	-1.1	0.8	0.1
Cocaine induced anxiety	0.2	0.2	0.5	0.3	0.4	-0.2	0.7
Post-drug Anxiety	1.3	1.4	2.0	1.4	1.4	-1.4	0.4
Baseline Anxiety	1.6	1.7	2.3	1.3	1.2	-1.5	-1.0
Tail length	0.1	0.3	0.5	-0.5	-0.7	-0.1	0.6
Length with tail	0.3	1.1	2.3	-1.2	-1.5	0.6	0.1
Length without tail	1.1	2.3	3.2	-1.7	-1.8	1.6	-0.8
Times rat made contact with spout	1.9	2.2	3.3	-1.7	-1.7	1.8	0.1
Lifetime Intake	1.7	2.0	2.4	1.5	1.5	-1.0	-1.5
Liver weight, left	0.2	0.3	0.5	-0.7	-0.7	0.1	-0.2
Liver weight, right	0.2	0.3	0.7	-0.6	-0.8	-0.2	-0.4
Locomotor activity	0.1	0.2	0.3	-0.5	-0.5	0.2	-0.4
Locomotor testing distance	0.0	0.1	0.1	-0.4	-0.4	-0.0	-0.1
Locomotor testing rearing	0.0	0.0	0.1	-0.2	-0.2	-0.3	0.1
Locomotion in novel chamber	0.3	0.3	0.5	0.5	0.5	-0.5	-0.7
Locomotion in novel chamber post-restriction	0.1	0.1	0.2	0.5	0.4	-0.2	-0.3
Fecal boli incidents, locomotor time 1	1.2	1.3	2.3	-1.3	-1.5	1.0	-0.2
Change in fecal boli incidents, locomotor task	0.7	0.6	1.9	-0.1	0.3	0.7	1.4
Time >=10cm from walls, locomotor time 1	0.6	0.6	0.8	-0.8	-0.7	0.9	0.7
Bouts of movement, locomotor time 1	0.1	0.2	0.3	-0.4	-0.5	0.4	-0.0
Total resting periods, locomotor time 1	0.1	0.1	0.2	-0.4	-0.5	0.5	-0.1
Rest time, locomotor task time 1	0.6	0.7	1.0	-1.0	-1.0	0.9	-0.4
Distance moved, locomotor task time 1	0.7	0.8	1.8	0.8	0.8	-1.3	0.1
Vertical activity count, locomotor time 1	0.3	0.3	0.6	0.6	0.5	-0.8	0.0
Time >=10cm from walls, locomotor time 2	0.2	0.2	1.0	0.1	0.1	0.1	-1.0
Bouts of movement, locomotor time 2	0.7	0.7	1.4	0.7	0.4	-1.2	-0.9
Total resting periods, locomotor time 2	0.4	0.5	0.9	0.5	0.3	-0.9	-0.8
Rest time, locomotor task time 2	1.0	1.2	1.9	1.1	1.1	-0.7	-1.4
Distance moved, locomotor task time 2	0.3	0.4	1.1	-0.3	-0.3	-0.5	1.0
Vertical activity count, locomotor time 2	0.1	0.1	0.2	-0.4	-0.4	0.0	0.3
Light reinforcement 1	1.3	2.4	4.8	-1.9	-2.2	1.1	0.2
Light reinforcement 2	0.2	0.3	0.6	0.3	0.4	0.4	-0.8
Bone: marrow area	4.5	9.7	13.0	-3.3	-3.2	3.6	2.2
Bone: maximum diameter	5.8	10.7	15.6	-3.5	-3.4	4.0	1.7
Bone: maximum force	0.7	1.1	1.6	-1.2	-1.2	1.3	0.3
Bone: maximum moment	0.4	0.6	1.1	-0.9	-0.9	1.0	-0.1
Mean time between licks in bursts	0.3	0.4	0.7	0.7	0.7	-0.2	-0.8
Mean num. licks in bursts	0.6	0.7	1.9	0.6	0.5	-0.6	-1.4
Cd content in liver	0.2	0.2	0.4	-0.4	-0.6	0.1	0.5
Co content in liver	0.6	0.7	2.1	0.3	-0.1	-0.9	-1.5
Cu content in liver	0.6	0.8	1.9	0.6	0.4	-0.8	-1.4
Fe content in liver	1.3	1.6	5.9	-0.3	0.1	0.7	2.4
K content in liver	0.1	0.1	0.3	-0.2	-0.2	0.2	0.5
Mg content in liver	0.8	0.8	1.4	-1.1	-1.2	0.6	0.6
Mn content in liver	0.4	0.4	1.2	0.4	0.5	0.2	-1.1
Na content in liver	0.4	0.4	1.4	-0.2	-0.0	0.5	1.2
Rb content in liver	1.4	1.8	3.0	-1.3	-1.2	1.0	1.7
Se content in liver	0.9	1.1	1.9	1.3	1.4	-0.8	-0.6
Sr content in liver	0.3	0.2	0.5	-0.4	-0.5	0.7	0.3
Zn content in liver	0.5	0.6	1.9	0.4	0.2	-0.4	-1.4
Bone: minimum diameter	0.3	0.5	0.9	-0.5	-0.5	1.0	-0.7
Time in familiar zone, hab. session 1	1.7	1.6	2.6	-1.3	-1.2	1.6	0.9
Time in novel zone, hab. session 1	1.1	1.1	2.0	0.8	0.7	-1.4	-1.2
Total zone transitions, hab. session 1	1.2	1.7	3.0	1.4	1.3	-1.7	0.2
Total locomotion distance, hab. session 1	2.0	2.9	5.7	1.8	1.6	-2.4	0.0
Locomotion velocity, hab. session 1	1.3	1.8	3.2	1.5	1.4	-1.8	0.2
Time in familiar zone, hab. session 2	0.3	0.3	0.4	-0.6	-0.5	0.6	0.6
Time in novel zone, hab. session 2	0.1	0.1	0.3	0.2	0.2	-0.1	-0.5
Total zone transitions, hab. session 2	0.6	0.8	2.1	0.7	0.4	-1.5	0.6
Total locomotion distance, hab. session 2	0.9	1.2	3.2	1.0	0.8	-1.8	0.1
Locomotion velocity, hab. session 2	1.2	1.6	3.5	1.3	1.0	-1.9	-0.1
Novel to familiar place preference ratio	0.4	0.4	0.6	-0.7	-0.7	0.6	-0.0
Novelty place preference	1.0	1.0	1.4	-1.1	-1.2	1.1	0.0
Time in novel zone, NPP test	1.6	1.7	2.3	-1.5	-1.5	1.5	0.2
Total zone transitions, NPP test	0.2	0.3	0.9	0.1	0.0	-0.6	1.0
Total locomotion distance, NPP test	0.4	0.5	1.2	0.3	0.2	-1.1	0.8
Locomotion velocity, NPP test	0.8	1.1	2.4	0.9	0.8	-1.6	0.8
Intraocular pressure	0.1	0.1	0.2	-0.4	-0.4	0.2	0.1
Delta distance traveled before/after self-admin	0.6	0.7	1.3	-1.0	-1.1	0.6	-0.3
Delta ambulatory time before/after self-admin	0.6	0.6	0.9	-0.9	-1.0	0.7	-0.4
Parametrial fat weight	0.1	0.1	0.2	0.3	0.3	-0.4	0.2
Pavlov. Cond. lever latency	1.2	1.5	2.0	1.1	1.1	-1.4	-1.3
Pavlov. Cond. magazine entry latency	0.1	0.1	0.3	0.3	0.2	-0.1	-0.6
Pavlov. Cond. change in total contacts	0.1	0.1	0.1	-0.1	-0.3	0.2	-0.3
Pavlov. Cond. index score	0.1	0.1	0.1	-0.1	-0.3	0.4	0.2
Pavlov. Cond. latency score	0.1	0.2	0.2	-0.2	-0.4	0.5	0.4
Pavlov. Cond. lever contacts	0.6	0.7	1.1	-0.8	-0.9	1.0	0.7
Pavlov. Cond. magazine entry number	0.1	0.1	0.3	-0.5	-0.4	0.2	0.3
Pavlov. Cond. intertrial magazine entries	1.0	1.2	4.0	-0.7	-0.6	-0.2	2.0
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.3	-0.2	-0.3	0.5	0.3
Pavlov. Cond. response bias	0.0	0.0	0.1	-0.0	-0.2	0.2	0.0
Pavlov. Cond. lever latency	2.6	3.5	4.4	2.1	2.0	-1.8	-1.6
Pavlov. Cond. magazine entry latency	0.8	0.9	1.9	1.2	1.4	-0.5	0.1
Pavlov. Cond. change in total contacts	0.5	0.7	0.9	-0.9	-0.9	0.9	0.7
Pavlov. Cond. index score	0.8	1.0	1.4	-0.9	-0.8	1.1	1.2
Pavlov. Cond. latency score	1.1	1.4	1.9	-1.1	-0.9	1.4	1.3
Pavlov. Cond. lever contacts	2.6	3.6	4.5	-2.1	-2.0	1.9	1.5
Pavlov. Cond. magazine entry number	0.2	0.2	0.6	-0.2	-0.5	-0.2	-0.8
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.3	-0.4	-0.6	0.4	-0.4
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	1.0	-0.8	-0.6	1.0	1.0
Pavlov. Cond. response bias	0.6	0.9	1.2	-1.0	-0.8	0.8	1.1
Time in closed arm before self-admin	0.6	0.6	0.8	-0.9	-0.8	0.9	0.6
Time in closed arm after self-admin	0.4	0.5	1.4	0.4	0.3	-0.4	-1.2
Time in open arm before self-admin	1.2	1.3	1.8	-1.3	-1.3	1.3	0.0
Time in open arm after self-admin	0.7	0.8	2.6	-0.2	0.2	0.7	1.6
Bone: periosteal estimation	2.9	6.1	9.0	-2.6	-2.5	3.0	1.4
Bone: periosteal perimeter	1.5	2.5	3.6	-1.6	-1.4	1.9	1.3
Bone: post-yield work	3.4	4.7	5.6	-2.4	-2.3	2.0	2.0
Progressive ratio test 1 active lever presses	0.4	0.4	1.5	0.2	0.2	-0.2	-1.2
Progressive ratio test 1 breakpoint	0.4	0.4	1.6	0.2	0.1	0.1	-1.2
Progressive ratio test 1 inactive lever presses	0.6	0.6	1.2	0.7	0.7	-0.6	-1.1
Progressive ratio test 2 active lever presses	0.4	0.4	0.8	0.5	0.4	-0.6	-0.9
Progressive ratio test 2 breakpoint	0.2	0.2	0.4	0.3	0.3	-0.5	-0.6
Progressive ratio test 2 inactive lever presses	1.7	2.0	2.4	1.5	1.5	-1.0	-1.6
Incentive Sensitization - Responses	0.4	0.4	0.6	0.5	0.4	-0.8	-0.6
Incentive Sensitization - Breakpoint	0.6	0.6	1.1	0.7	0.6	-1.0	-0.8
Sum of active levers in priming session hrs 5-6	0.5	0.5	0.9	-0.6	-0.5	0.9	0.7
Progressive ratio	0.8	1.0	1.8	-1.1	-1.3	0.8	-0.5
Food seeking constrained by brief footshock	4.9	6.0	8.3	-2.9	-2.8	2.0	2.0
Seeking ratio, punishment vs. effort	0.8	1.0	3.0	-0.8	-0.6	0.3	1.7
Retroperitoneal fat weight	0.8	2.8	4.5	1.4	0.9	-2.1	-2.0
Reaction time number correct	0.5	0.8	2.7	-0.4	-0.2	0.4	1.7
Reaction time mean minus median	1.5	2.0	2.1	1.4	1.4	-1.4	-1.5
Reaction time mean minus median AUC	1.0	1.3	1.6	1.2	1.3	-1.2	-1.0
Reaction time num false alarms	1.0	1.4	2.3	1.3	1.3	-1.5	-0.2
Reaction time num false alarms AUC	1.2	1.6	2.7	1.4	1.4	-1.6	-0.1
Reaction time trials correct on left	0.5	0.8	2.7	-0.4	-0.2	0.4	1.7
Reaction time trials on left	0.5	0.7	2.7	-0.3	-0.1	0.3	1.7
Reaction time mean	1.1	1.6	1.9	1.4	1.4	-0.9	-1.3
Reaction time mean AUC	0.7	1.0	1.3	1.1	1.1	-0.6	-1.0
Median of all reaction times	1.1	1.4	1.8	1.3	1.4	-0.8	-1.3
Reaction time omissions	1.8	2.5	3.5	1.8	1.8	-1.9	-0.3
Reaction time false alarm rate	1.5	2.1	3.3	1.5	1.4	-1.8	-1.1
Reaction time premature initiation rate	0.1	0.1	0.3	-0.4	-0.5	-0.2	-0.1
Reaction time premature initiations	0.2	0.3	0.4	-0.6	-0.6	-0.0	0.7
Std. dev. reaction times	1.8	2.5	3.0	1.7	1.7	-1.5	-1.3
Reaction time trials completed	0.5	0.7	2.7	-0.3	-0.1	0.3	1.7
Reaction time trials AUC	0.6	0.9	3.1	-0.4	-0.2	0.4	1.8
Run reversals in cocaine runway, females	1.2	1.2	1.9	0.9	0.9	-1.0	-1.4
Run reversals in cocaine runway, males	1.2	1.2	2.1	-1.1	-1.1	0.6	1.5
Latency to leave start box in cocaine runway	0.2	0.2	0.6	-0.1	0.0	0.4	0.7
Latency to leave start box in cocaine runway, F	0.1	0.1	0.2	-0.4	-0.4	0.3	0.4
Latency to leave start box in cocaine runway, M	0.4	0.4	0.8	0.8	0.9	-0.4	0.2
Std. dev. time between licks in bursts	0.7	0.8	1.7	-0.7	-0.6	0.9	1.3
Total sessions with >9 infusions	0.1	0.2	0.4	0.1	0.2	0.3	-0.7
Short access day 1 total inactive lever presses	0.3	0.3	1.2	0.1	0.0	-0.1	-1.1
Short access day 10 total inactive lever presses	0.0	0.0	0.1	0.1	0.1	-0.2	0.3
Short access day 1 total infusions	0.6	0.7	1.1	0.9	0.8	-0.2	-1.1
Short access day 10 total infusions	1.0	1.1	1.9	1.2	1.4	-0.4	-1.0
Short access total infusions	3.4	3.8	4.7	2.1	2.2	-1.5	-2.0
Short access day 1 locomotion	0.3	0.3	0.6	-0.5	-0.5	0.8	-0.1
Short access day 10 total locomotion	0.2	0.2	0.6	-0.2	-0.2	0.8	0.2
Short access total locomotion	0.6	0.6	1.5	0.7	0.7	-0.0	-1.2
One hour access (0.3 mA shock)	0.6	0.7	0.9	0.9	0.9	-0.7	-0.8
Compulsive drug intake	0.1	0.1	0.2	0.0	0.2	0.4	-0.3
One hour access (shock baseline)	0.2	0.2	0.3	0.5	0.5	-0.3	-0.3
Social response proportion	1.0	1.1	1.7	1.0	1.0	-1.0	-1.3
Social responses	0.1	0.2	0.4	0.2	0.1	-0.4	-0.7
Social time	0.1	0.1	0.3	0.1	0.2	-0.6	0.0
Soleus weight	7.8	22.8	29.5	-5.4	-5.4	4.3	3.8
Bone: stiffness	0.2	0.3	0.6	-0.5	-0.4	0.3	0.8
Tibialis anterior weight	4.7	15.9	18.7	-4.3	-4.2	4.1	3.3
Time to tail flick, vehicle, before self-admin	0.7	0.7	1.8	-0.7	-0.6	0.5	1.3
Time to tail flick, vehicle, after self-admin	2.6	2.8	4.5	-1.6	-1.4	2.1	1.5
Time to tail flick, test, before self-admin	0.1	0.1	0.2	-0.3	-0.4	-0.1	-0.2
Time to tail flick, test, after self-admin	1.3	1.4	1.8	-1.3	-1.3	1.2	0.8
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	1.0	-0.8	-0.7	1.0	0.6
Delta time to tail flick, test, before/after SA	1.3	1.2	1.9	-1.1	-0.9	1.4	0.9
Tibia length	1.0	2.9	4.4	-1.5	-1.6	2.1	-1.5
Ambulatory time before self-admin	0.3	0.4	0.7	-0.4	-0.3	0.7	0.8
Ambulatory time after self-admin	2.6	2.8	4.0	-1.8	-1.7	2.0	1.1
Bone: tissue strength	0.4	0.4	0.5	0.7	0.7	-0.7	-0.4
Total heroin consumption	2.4	2.8	3.4	-1.8	-1.8	1.8	1.2
Bone: trabecular number	0.2	0.3	0.9	0.2	0.3	-0.0	0.9
Bone: trabecular spacing	2.5	3.3	5.0	1.7	1.5	-2.2	-1.7
Bone: trabecular thickness	0.2	0.2	0.5	-0.2	-0.2	0.5	-0.7
Bone: trabecular tissue density	0.4	0.6	2.2	0.2	0.1	-0.2	-1.5
Water consumed over 24 hours	2.6	3.1	4.4	-2.0	-2.0	2.1	0.5
Number of responses in last shaping day	2.1	2.2	3.7	-1.6	-1.6	1.9	0.0