Hub : Genes

LOC100912202

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL mRNA stability LOC100912202 0.08 0.04 1.1e-08 0.05 0.08 0.08 0.06 5.4e-06 5.9e-09 5.6e-09 1.1e-07
2 BLA mRNA stability LOC100912202 0.07 0.04 1.7e-03 0.04 0.04 0.01 0.02 3.9e-03 5.8e-03 9.6e-02 2.2e-02
3 Liver gene expression LOC100912202 0.17 0.06 0.0e+00 0.15 0.17 0.18 0.19 3.9e-16 5.4e-19 1.4e-19 2.4e-20
4 PL gene expression LOC100912202 0.27 0.08 0.0e+00 0.28 0.31 0.31 0.32 2.9e-31 5.3e-35 3.4e-35 2.8e-35
5 LHb gene expression LOC100912202 0.31 0.12 9.0e-06 0.19 0.18 0.17 0.17 2.3e-05 4.2e-05 7.0e-05 9.5e-05
6 NAcc gene expression LOC100912202 0.22 0.07 0.0e+00 0.16 0.2 0.2 0.19 1.3e-17 5.8e-23 2.0e-22 8.4e-22
7 pVTA gene expression LOC100912202 0.15 0.07 9.9e-06 0.04 0.08 0.1 0.09 9.7e-03 1.9e-04 2.8e-05 1.0e-04
8 pVTA mRNA stability LOC100912202 0.16 0.08 1.6e-03 0.08 0.03 0.05 0.05 2.4e-04 1.4e-02 3.4e-03 4.7e-03
9 Brain gene expression LOC100912202 0.26 0.08 0.0e+00 0.24 0.34 0.33 0.3 1.3e-22 2.9e-32 1.9e-31 1.1e-28
10 IL gene expression LOC100912202 0.34 0.13 3.9e-05 0.02 0.15 0.07 0.1 8.8e-02 2.0e-04 8.2e-03 2.4e-03
11 OFC gene expression LOC100912202 0.37 0.12 7.5e-07 0.18 0.3 0.29 0.28 5.0e-05 7.2e-08 1.2e-07 3.0e-07
12 BLA gene expression LOC100912202 0.36 0.13 1.9e-13 0.18 0.2 0.16 0.17 7.0e-10 5.8e-11 3.4e-09 3.2e-09
13 Brain mRNA stability LOC100912202 0.15 0.07 1.3e-12 0.12 0.15 0.15 0.15 1.7e-11 1.3e-13 5.8e-14 5.0e-14
14 NAcc mRNA stability LOC100912202 0.03 0.02 2.6e-03 0.04 0.01 0.03 0.03 1.3e-05 1.2e-02 2.8e-04 1.6e-04
15 Adipose gene expression LOC100912202 0.15 0.08 2.6e-10 0.08 0.06 0.07 0.06 5.3e-09 9.5e-08 6.1e-08 2.0e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density4.37.211.72.42.9-3.2-2.72.7-2.23.30.4-2.8-2.3-2.5-2.4-3.42.83.0
Area under the delay curve0.00.00.10.10.20.1-0.20.1-0.10.10.1-0.1-0.2-0.00.10.1-0.3-0.4
BMI with tail5.216.923.5-4.4-3.54.23.9-3.53.8-3.4-2.34.83.74.84.44.8-4.8-4.4
BMI without tail4.810.015.1-3.5-2.02.62.9-2.03.3-1.8-3.53.43.73.83.93.0-3.4-3.3
Body weight4.016.632.0-4.2-2.93.83.3-2.93.1-3.3-2.04.63.34.84.45.0-5.7-5.6
Weight adjusted by age2.73.06.2-1.3-1.72.01.4-1.60.9-2.00.62.00.71.91.62.2-2.5-2.2
Bone surface5.59.816.63.03.8-3.7-3.43.6-2.94.10.1-3.3-2.8-2.7-2.5-3.62.72.6
Bone volume4.88.215.52.83.6-3.5-3.23.4-2.53.9-0.2-3.0-2.5-2.3-2.0-3.32.22.3
Breakpoint value in progressive ratio session1.71.93.5-1.9-1.71.71.4-1.61.3-1.6-0.21.41.21.21.01.4-1.1-1.2
Number of licking bursts0.00.10.30.10.1-0.1-0.30.2-0.30.10.1-0.0-0.30.00.00.0-0.5-0.4
Context. condit. distance diff. score0.10.10.3-0.4-0.10.30.0-0.0-0.2-0.30.50.1-0.1-0.0-0.10.4-0.3-0.5
Locomotion velocity, session 10.30.30.8-0.7-0.40.70.7-0.50.9-0.3-0.80.50.70.60.70.2-0.3-0.1
Locomotion distance, session 10.60.82.4-0.9-0.60.81.1-0.71.4-0.1-1.50.81.11.11.20.3-0.4-0.2
Locomotion velocity, session 20.50.52.9-0.5-0.30.10.7-0.31.20.3-1.70.31.00.50.8-0.40.40.6
Locomotion distance, session 20.60.93.4-0.8-0.50.41.1-0.71.60.0-1.80.71.21.01.1-0.40.10.7
Locomotion velocity, session 33.33.96.8-2.2-1.81.82.3-1.92.6-1.2-2.32.12.32.32.21.6-1.0-0.9
Locomotion distance, session 30.10.10.20.40.5-0.4-0.20.4-0.20.5-0.3-0.1-0.3-0.0-0.1-0.20.20.2
Stereotopy head waving bouts, day 30.70.82.3-0.9-1.31.11.2-1.50.9-1.10.40.20.7-0.3-0.20.10.80.9
Stereotopy head waving duration, day 30.30.41.2-0.6-1.00.70.8-1.10.8-0.5-0.20.10.6-0.10.10.00.70.7
Locomotion velocity, session 70.10.10.2-0.10.3-0.2-0.00.30.10.5-0.4-0.2-0.0-0.0-0.0-0.30.50.4
Locomotion distance, session 70.50.71.80.71.2-1.1-0.91.2-0.61.3-0.4-0.7-0.7-0.4-0.4-0.70.60.3
Stereotopy head waving bouts, day 70.20.21.0-0.6-0.4-0.00.5-0.60.4-0.1-0.00.10.3-0.0-0.2-0.40.71.0
Stereotopy head waving duration, day 70.30.42.1-0.2-0.4-0.00.3-0.50.2-0.20.4-0.20.0-0.5-0.7-0.71.21.5
Locomotion velocity, session 80.00.00.1-0.0-0.10.10.2-0.1-0.0-0.20.30.0-0.1-0.00.10.1-0.2-0.1
Locomotion distance, session 80.40.62.2-1.0-0.30.50.9-0.41.20.1-1.50.71.00.91.00.2-0.3-0.0
Degree of sensitization distance0.10.10.30.00.4-0.4-0.30.3-0.20.5-0.2-0.4-0.1-0.3-0.1-0.30.20.1
Degree of sensitization stereotypy0.20.20.5-0.7-0.30.10.6-0.40.6-0.0-0.40.50.50.40.2-0.10.20.5
Conditioned locomotion0.10.20.80.20.4-0.5-0.10.4-0.00.6-0.9-0.40.2-0.2-0.1-0.40.50.4
Cocaine response after cond. corrected1.01.12.01.31.1-1.4-1.31.1-1.40.90.8-1.0-1.3-0.9-0.8-0.80.30.3
Cocaine response after cond. not corrected1.11.32.31.41.3-1.5-1.41.3-1.41.10.7-1.1-1.3-1.0-0.9-0.90.40.4
Cocaine response before conditioning0.20.20.9-0.4-0.20.40.4-0.00.70.1-1.00.30.60.40.40.20.10.1
Saline control response5.67.39.4-3.1-2.22.82.8-2.32.9-1.9-2.43.03.03.12.92.7-2.5-2.6
Bone: connectivity density4.26.612.11.82.5-2.9-2.12.4-1.73.2-0.0-2.7-1.8-2.5-2.4-3.33.53.4
Bone: cortical apparent density2.33.06.0-1.9-2.32.02.2-2.51.7-2.40.41.61.81.01.01.7-0.9-0.7
Bone: cortical area1.21.76.4-1.0-0.20.71.0-0.41.60.2-2.51.11.81.72.00.9-1.2-1.0
Bone: cortical porosity0.70.82.00.61.3-1.1-1.01.4-0.51.4-1.3-0.7-0.2-0.2-0.1-0.80.20.1
Bone: cortical porosity0.50.52.00.31.0-0.8-0.71.0-0.21.1-1.4-0.2-0.00.20.4-0.4-0.4-0.5
Bone: cortical thickness9.215.121.1-4.2-4.04.14.6-4.34.6-3.5-2.74.14.54.04.03.6-2.9-2.4
Bone: cortical thickness2.52.95.4-2.1-2.01.72.3-2.12.3-1.5-1.31.62.31.41.51.1-0.5-0.2
Bone: cortical tissue density2.12.85.6-1.9-2.21.92.1-2.41.6-2.30.41.51.70.90.91.6-0.9-0.6
Condit. Reinf. active minus inactive responses0.20.31.1-0.20.50.2-0.10.50.10.2-0.80.20.30.50.60.5-1.1-0.9
Condit. Reinf. active-inactive response ratio0.20.30.60.40.60.0-0.70.7-0.80.10.6-0.6-0.5-0.6-0.70.10.0-0.2
Condit. Reinf. active responses0.30.42.0-0.30.7-0.1-0.10.60.30.6-1.40.20.50.60.70.2-0.8-0.5
Condit. Reinf. inactive responses0.50.64.1-0.30.4-0.40.30.40.80.9-2.00.40.60.91.0-0.2-0.10.2
Incentive salience index mean0.10.10.5-0.30.40.1-0.00.30.10.2-0.50.20.30.40.30.2-0.7-0.4
Condit. Reinf. lever presses0.30.30.7-0.8-0.30.60.7-0.40.6-0.5-0.20.80.60.80.50.6-0.7-0.3
Condit. Reinf. active minus inactive responses1.72.27.11.12.3-1.9-1.32.1-0.62.7-2.1-1.1-0.4-0.4-0.1-1.40.60.7
Condit. Reinf. active-inactive response ratio2.52.66.51.62.4-2.1-1.82.3-1.42.5-0.7-1.5-1.3-1.0-0.9-1.70.90.8
Condit. Reinf. active responses1.72.38.60.82.3-1.9-1.12.1-0.22.9-2.9-0.90.00.00.3-1.20.50.5
Condit. Reinf. inactive responses1.21.510.0-1.00.10.20.9-0.01.50.7-3.20.71.71.31.50.4-0.2-0.3
Condit. Reinf. lever presses0.71.06.8-0.70.7-0.00.30.60.80.9-2.60.51.21.01.10.2-0.6-0.5
Condit. Reinf. lever reinforcers received1.31.97.10.62.2-1.6-1.02.0-0.32.6-2.7-0.80.10.00.3-1.00.30.3
Conditioned reinforcement - actives1.41.44.11.10.9-1.3-0.70.8-0.31.2-0.4-1.2-0.5-1.1-1.0-1.81.92.0
Conditioned reinforcement - inactives0.10.10.60.50.3-0.8-0.30.3-0.10.5-0.5-0.2-0.30.00.2-0.5-0.10.3
Conditioned locomotion0.91.13.21.21.6-1.2-1.21.8-0.71.8-0.8-0.8-0.7-0.4-0.4-0.80.30.4
Patch foraging indifference point 0 sec3.15.115.4-2.2-0.61.11.7-0.92.4-0.2-3.92.12.72.73.11.9-2.4-2.7
Patch foraging indifference point AUC0.40.51.7-0.5-0.50.80.5-0.50.4-0.4-0.30.50.70.50.71.3-1.0-1.0
Delay disc. indifference point, 0s delay0.50.51.70.50.7-0.4-0.80.7-0.90.41.3-0.6-1.0-0.7-0.9-0.50.30.1
Delay disc. indifference point, 16s delay0.50.51.4-0.6-0.50.90.5-0.50.4-0.5-0.10.60.50.60.70.9-1.0-1.2
Delay disc. indifference point, 2s delay0.20.20.70.80.4-0.6-0.70.5-0.60.40.2-0.5-0.5-0.4-0.2-0.30.1-0.2
Delay disc. indifference point, 24s delay0.20.21.1-0.00.7-0.3-0.30.5-0.01.0-1.0-0.2-0.00.10.2-0.3-0.2-0.3
Delay disc. indifference point, 4s delay0.10.10.40.30.10.2-0.2-0.0-0.2-0.30.6-0.3-0.2-0.3-0.20.0-0.10.0
Delay disc. indifference point, 8s delay0.60.71.7-0.7-1.11.30.9-1.20.6-1.10.60.70.50.50.41.0-0.5-0.5
Indifference point function ln k0.50.85.1-0.10.2-0.50.30.31.00.9-2.2-0.10.80.30.5-0.81.30.8
Indifference point function log k0.50.85.1-0.10.2-0.50.30.31.00.9-2.2-0.10.80.30.5-0.81.30.8
Patch foraging total patch changes 0 sec3.35.215.2-2.3-0.81.11.8-1.02.4-0.3-3.92.22.82.83.11.9-2.4-2.6
Patch foraging total patch changes 12 sec1.11.44.0-1.10.10.50.7-0.20.90.2-2.00.91.31.31.51.4-1.6-1.7
Patch foraging total patch changes 18 sec4.05.18.2-2.0-1.61.92.0-1.82.3-1.1-2.42.42.52.62.92.6-2.5-2.6
Patch foraging total patch changes 24 sec1.72.18.7-1.2-0.10.50.8-0.41.50.5-2.91.11.71.72.11.0-1.5-1.6
Patch foraging total patch changes 6 sec3.04.511.9-1.9-0.61.41.3-0.71.7-0.5-2.71.92.22.42.62.6-2.9-3.4
Patch foraging time to switch 0 sec0.81.26.20.90.5-0.8-1.20.5-1.6-0.22.5-0.8-1.6-1.1-1.2-0.7-0.20.2
Patch foraging water rate 0 sec1.72.78.9-1.8-0.51.31.6-0.72.0-0.2-3.01.52.21.81.81.6-1.1-1.3
Patch foraging water rate 12 sec2.13.24.1-1.9-1.62.01.9-1.62.0-1.4-1.41.92.01.91.82.0-1.4-1.7
Patch foraging water rate 18 sec0.30.31.2-1.1-0.20.00.6-0.30.90.1-1.10.30.70.30.2-0.20.50.7
Patch foraging water rate 24 sec0.20.31.7-0.40.00.20.5-0.10.90.3-1.30.10.60.20.1-0.20.81.0
Patch foraging water rate 6 sec0.71.02.4-1.6-1.01.11.3-1.11.2-0.6-0.80.81.40.60.70.9-0.1-0.3
Seeking ratio, delayed vs. immediate footshock1.31.53.1-1.0-1.21.71.0-0.90.8-1.3-0.11.30.81.21.21.6-1.7-1.8
Distance traveled before self-admin0.20.21.00.3-0.30.4-0.3-0.1-0.4-0.81.0-0.1-0.6-0.2-0.10.1-0.5-0.4
Distance traveled after self-admin0.20.20.8-0.1-0.40.70.1-0.4-0.1-0.80.90.2-0.20.00.00.4-0.9-0.3
Extensor digitorum longus weight0.93.77.0-1.3-2.22.11.4-2.20.8-2.61.62.10.41.71.32.4-2.4-2.5
Bone: elastic displacement1.31.53.9-1.4-1.10.81.5-1.11.9-0.4-2.01.21.71.31.30.5-0.00.1
Bone: elastic work1.41.85.3-1.5-0.90.91.4-0.81.9-0.3-2.31.41.81.71.50.7-0.5-0.5
Bone: endosteal estimation6.313.727.64.15.2-4.4-4.85.3-4.14.8-0.0-3.8-3.6-2.8-2.3-3.21.10.8
Bone: endosteal perimeter6.212.927.84.25.3-4.2-4.65.3-3.74.9-0.6-3.5-3.2-2.3-1.9-3.01.30.9
Epididymis fat weight4.29.722.4-2.8-3.03.42.4-2.91.4-3.81.23.31.72.82.44.0-4.4-4.7
Delta time in closed arm before/after self-admin3.93.84.72.11.8-1.7-2.12.0-1.91.51.4-2.1-1.9-2.1-2.1-2.12.21.9
Delta time in open arm before/after self-admin0.20.20.6-0.2-0.4-0.30.4-0.50.40.1-0.5-0.10.2-0.10.1-0.50.70.6
Diff in mean of infusions in LGA sessions1.01.11.8-1.1-1.21.31.0-1.31.0-1.10.11.20.71.21.00.8-1.4-0.8
Delay discount exponential model param0.10.10.2-0.3-0.40.10.4-0.40.3-0.3-0.00.30.30.20.00.00.20.3
Extinction: sum of active levers before priming0.10.10.4-0.3-0.1-0.1-0.10.1-0.2-0.30.10.00.1-0.00.00.3-0.5-0.6
Active lever presses in extinction session 60.10.10.5-0.4-0.2-0.10.1-0.10.3-0.0-0.20.30.20.40.3-0.1-0.7-0.2
Bone: final force0.20.31.00.30.8-0.6-0.60.8-0.41.0-0.7-0.6-0.2-0.4-0.2-0.50.10.0
Bone: final moment0.20.30.90.30.7-0.5-0.50.7-0.41.0-0.7-0.6-0.2-0.4-0.1-0.50.20.1
Food consumed during 24 hour testing period5.16.29.3-3.0-2.72.82.7-2.62.3-2.8-0.82.52.52.22.32.6-2.5-2.4
Glucose0.00.10.30.5-0.20.2-0.2-0.0-0.20.00.30.0-0.50.10.10.2-0.1-0.4
Heart weight0.60.93.40.21.0-0.5-0.40.90.31.1-1.80.60.11.31.40.2-1.1-1.1
Delay discount hyperbolic model param0.10.10.2-0.3-0.30.10.3-0.30.3-0.2-0.10.20.30.1-0.0-0.10.30.4
Intermittent access intake day 1-15 change0.30.30.91.00.90.1-0.60.9-0.7-0.10.4-0.4-0.6-0.4-0.60.1-0.30.1
Intermittent access intake escalation0.50.51.51.21.0-0.1-0.91.0-1.00.00.8-0.6-0.9-0.7-0.8-0.1-0.10.1
Intermittent access intake escalation 21.31.22.21.31.5-0.6-1.41.5-1.50.41.0-1.2-1.1-1.3-1.4-0.40.30.3
Intermitt. access day 1 inactive lever presses0.30.42.1-0.30.1-0.10.30.00.60.3-1.50.40.80.70.90.2-0.5-0.7
Intermitt. access day 15 inactive lever presses0.20.20.9-0.1-0.40.50.2-0.40.0-0.90.90.5-0.10.30.20.3-0.9-0.2
Intermitt. access escalation Index0.20.20.50.20.5-0.5-0.40.5-0.50.40.1-0.6-0.2-0.7-0.7-0.30.60.3
Intermittent access day 1 total infusions0.80.93.0-0.7-0.50.41.0-0.51.50.4-1.70.91.31.21.2-0.1-0.20.4
Intermittent access day 15 total infusions0.10.20.60.50.7-0.0-0.20.70.10.4-0.6-0.00.10.20.1-0.2-0.30.4
Intermittent access terminal intake (last 3 days)0.40.41.40.71.2-0.4-0.71.2-0.40.6-0.1-0.6-0.4-0.5-0.6-0.60.10.7
Intermittent access total infusions0.30.31.8-0.10.10.30.50.10.90.3-1.40.40.90.70.6-0.0-0.10.4
Intermittent access day 1 locomotion0.30.31.3-0.30.30.10.20.20.70.6-1.10.60.30.90.8-0.1-0.90.1
Intermittent access day 15 total locomotion0.90.92.71.01.6-1.3-1.01.5-0.61.4-0.6-0.7-0.6-0.4-0.3-0.9-0.00.6
Intermittent access total locomotion0.60.72.9-0.50.50.30.40.40.90.5-1.70.80.81.21.10.4-1.2-0.4
Intermittent access standard deviation0.20.20.90.90.70.2-0.40.60.10.4-0.5-0.0-0.20.30.3-0.0-0.30.2
Left kidney weight0.61.73.7-1.7-0.60.81.2-0.71.5-0.4-1.71.61.21.91.80.9-1.4-1.0
Right kidney weight0.10.31.0-1.00.50.20.10.40.30.0-0.60.70.20.90.50.4-1.0-0.6
Cocaine induced anxiety1.41.62.21.31.0-1.5-1.21.0-1.30.71.1-1.4-1.5-1.4-1.4-1.41.11.2
Post-drug Anxiety1.61.83.61.41.0-1.4-1.31.0-1.80.31.9-1.4-1.8-1.6-1.6-1.20.60.8
Baseline Anxiety0.70.71.4-0.9-1.01.00.9-1.20.5-1.20.30.80.70.60.51.0-0.8-0.9
Tail length0.20.52.9-0.40.5-0.2-0.20.6-0.10.1-0.80.30.60.50.70.5-1.1-1.7
Length with tail0.31.05.9-0.6-0.10.3-0.10.0-0.2-0.60.00.80.20.90.91.3-2.0-2.4
Length without tail0.30.64.20.0-0.40.4-0.3-0.4-0.9-0.92.10.2-1.1-0.2-0.60.7-0.7-0.7
Times rat made contact with spout0.70.81.2-1.1-0.70.80.8-0.50.9-0.5-1.01.01.01.10.90.9-1.0-0.9
Lifetime Intake0.70.84.3-0.4-0.20.20.7-0.21.40.4-2.10.71.21.01.1-0.1-0.10.4
Liver weight, left0.10.20.60.30.1-0.1-0.10.2-0.10.20.0-0.60.0-0.6-0.5-0.60.80.8
Liver weight, right0.50.82.5-1.1-1.41.31.0-1.40.6-1.60.90.50.8-0.00.10.6-0.2-0.2
Locomotor activity1.42.26.5-1.5-0.51.01.3-0.51.9-0.1-2.51.51.81.91.90.7-1.3-1.1
Locomotor testing distance1.93.210.7-1.7-0.61.31.5-0.62.4-0.0-3.31.82.32.32.31.1-1.4-1.1
Locomotor testing rearing3.65.58.1-2.6-1.62.32.3-1.62.7-1.3-2.72.62.72.82.72.2-2.3-2.1
Locomotion in novel chamber0.30.42.3-0.1-0.50.80.0-0.3-0.4-0.91.50.2-0.40.0-0.00.5-0.7-0.6
Locomotion in novel chamber post-restriction0.10.10.4-0.60.00.20.4-0.10.30.1-0.40.20.30.1-0.00.1-0.10.2
Fecal boli incidents, locomotor time 11.71.93.21.61.8-1.7-1.61.7-1.51.50.5-1.3-1.6-1.1-1.2-1.30.70.5
Change in fecal boli incidents, locomotor task0.50.51.2-0.4-0.91.00.6-0.90.3-1.00.10.50.50.20.31.1-0.6-0.8
Time >=10cm from walls, locomotor time 10.20.20.5-0.2-0.5-0.00.5-0.40.60.2-0.70.20.40.30.4-0.30.50.6
Bouts of movement, locomotor time 10.50.51.3-0.7-0.60.70.7-0.70.6-0.7-0.00.80.60.80.70.9-1.2-0.7
Total resting periods, locomotor time 10.10.10.3-0.0-0.10.20.1-0.1-0.1-0.40.50.2-0.00.10.10.3-0.6-0.4
Rest time, locomotor task time 10.30.31.11.00.2-0.2-0.50.1-0.8-0.11.0-0.3-0.8-0.5-0.70.20.4-0.1
Distance moved, locomotor task time 12.12.33.9-1.8-2.01.71.7-1.91.5-1.7-0.01.51.61.31.51.3-1.4-0.9
Vertical activity count, locomotor time 11.71.83.2-1.7-1.81.51.5-1.61.2-1.5-0.01.21.40.91.21.3-1.2-1.0
Time >=10cm from walls, locomotor time 23.13.35.5-2.0-2.32.32.0-2.21.6-2.20.02.01.41.71.51.7-1.7-1.4
Bouts of movement, locomotor time 24.04.36.0-2.5-2.12.22.1-2.21.9-2.0-0.82.31.82.22.02.4-2.1-2.2
Total resting periods, locomotor time 23.03.24.2-2.0-1.82.01.8-1.91.6-1.8-0.82.01.41.91.82.0-1.8-1.9
Rest time, locomotor task time 22.83.35.82.41.2-1.7-1.61.0-2.01.02.2-1.9-2.2-2.1-2.1-1.61.91.5
Distance moved, locomotor task time 25.26.09.5-3.1-3.03.02.7-2.82.3-2.90.02.52.52.11.92.5-2.1-1.7
Vertical activity count, locomotor time 23.84.17.1-2.7-2.12.22.1-1.92.1-1.9-1.02.12.51.81.92.0-2.0-1.5
Light reinforcement 12.34.27.0-2.5-1.92.02.4-2.02.6-1.2-2.22.12.62.22.21.7-1.2-1.1
Light reinforcement 20.10.20.4-0.2-0.30.50.4-0.30.6-0.1-0.60.50.40.60.50.3-0.1-0.1
Bone: marrow area6.313.627.14.15.1-4.3-4.85.2-4.24.70.1-3.8-3.7-2.8-2.4-3.21.10.9
Bone: maximum diameter2.13.88.42.42.9-2.2-2.32.8-1.72.9-0.7-2.0-1.5-1.2-0.8-1.81.00.8
Bone: maximum force0.40.72.10.61.3-0.9-0.91.2-0.51.5-1.1-0.6-0.4-0.20.0-0.7-0.00.0
Bone: maximum moment0.40.62.00.51.3-0.9-0.81.2-0.41.4-1.2-0.6-0.3-0.20.1-0.70.00.0
Mean time between licks in bursts0.20.31.00.00.20.1-0.40.3-0.6-0.40.90.3-0.70.3-0.10.8-0.8-1.0
Mean num. licks in bursts0.30.40.9-0.7-0.50.60.8-0.50.9-0.3-0.70.60.90.60.60.5-0.1-0.1
Cd content in liver2.22.43.91.61.1-1.1-1.41.1-1.50.81.8-1.5-1.8-1.6-2.0-1.61.81.8
Co content in liver0.91.12.31.10.9-0.8-1.20.9-1.40.51.5-0.9-1.5-1.0-1.3-0.80.40.5
Cu content in liver0.70.91.30.81.2-1.0-1.01.0-1.00.90.5-1.0-1.0-0.9-0.8-1.10.71.0
Fe content in liver0.10.10.40.1-0.2-0.0-0.10.00.10.3-0.4-0.30.1-0.2-0.1-0.20.60.3
K content in liver1.51.52.50.91.2-1.3-1.01.1-0.91.4-0.1-1.4-0.7-1.3-1.2-1.51.51.6
Mg content in liver2.22.35.70.91.2-1.5-1.01.1-0.91.50.1-1.7-0.7-1.8-1.7-2.02.32.4
Mn content in liver2.52.86.91.11.6-1.8-1.21.5-0.91.9-0.3-1.7-1.0-1.6-1.8-2.12.52.6
Na content in liver0.40.41.00.70.3-0.5-0.50.4-0.60.60.3-0.8-0.7-0.8-0.8-0.61.00.8
Rb content in liver0.40.52.00.2-0.40.1-0.3-0.2-0.5-0.31.4-0.7-0.7-1.1-1.1-0.41.00.8
Se content in liver0.10.10.4-0.0-0.2-0.00.2-0.40.3-0.10.00.1-0.00.0-0.1-0.30.50.6
Sr content in liver0.40.41.1-0.30.30.00.20.40.40.3-1.10.60.30.90.90.4-1.0-0.8
Zn content in liver1.41.64.00.91.4-1.4-0.81.3-0.41.6-0.7-1.1-0.6-0.8-0.8-2.01.42.0
Bone: minimum diameter2.64.813.72.33.7-2.7-2.73.4-1.93.5-1.4-1.8-1.5-0.7-0.2-1.7-0.20.1
Time in familiar zone, hab. session 10.70.71.40.91.1-0.7-1.01.2-1.20.70.7-0.8-1.0-0.7-0.7-0.40.0-0.1
Time in novel zone, hab. session 10.60.61.4-1.0-0.80.30.9-1.01.2-0.5-1.00.71.10.80.80.40.00.2
Total zone transitions, hab. session 11.21.62.7-1.5-1.01.21.4-1.11.6-0.8-1.11.61.41.61.50.9-1.2-0.7
Total locomotion distance, hab. session 12.23.24.7-2.2-1.61.82.1-1.72.2-1.4-1.51.92.11.92.01.4-1.5-1.2
Locomotion velocity, hab. session 11.92.74.3-2.1-1.51.91.9-1.52.0-1.3-1.21.81.91.71.71.3-1.4-1.1
Time in familiar zone, hab. session 20.20.20.50.30.6-0.6-0.50.7-0.40.4-0.3-0.2-0.2-0.00.10.1-0.4-0.6
Time in novel zone, hab. session 20.30.31.80.0-0.20.00.1-0.40.10.00.4-0.4-0.1-0.6-0.7-0.81.21.3
Total zone transitions, hab. session 21.92.54.7-1.6-1.41.51.7-1.52.2-1.0-1.61.91.72.12.00.7-1.3-0.7
Total locomotion distance, hab. session 24.05.27.7-2.5-2.32.52.6-2.32.8-2.1-1.72.52.62.42.51.8-1.9-1.5
Locomotion velocity, hab. session 23.54.77.1-2.4-2.32.42.6-2.32.7-2.0-1.52.42.42.22.31.6-1.7-1.3
Novel to familiar place preference ratio0.50.61.60.71.3-0.8-0.71.2-0.51.3-0.9-0.3-0.30.10.1-0.3-0.4-0.4
Novelty place preference0.50.51.50.81.2-0.8-0.71.1-0.51.2-0.7-0.3-0.50.1-0.0-0.4-0.2-0.1
Time in novel zone, NPP test0.40.41.40.71.1-0.8-0.61.0-0.41.2-0.8-0.3-0.40.10.0-0.4-0.2-0.1
Total zone transitions, NPP test2.53.67.9-2.1-1.71.72.3-1.92.8-1.2-2.31.92.42.12.30.7-1.1-0.3
Total locomotion distance, NPP test2.94.07.8-2.6-1.91.92.5-2.02.8-1.6-2.01.92.71.92.10.9-1.1-0.5
Locomotion velocity, NPP test3.65.19.1-2.7-2.22.22.7-2.33.0-1.9-2.02.32.82.32.51.3-1.6-0.9
Intraocular pressure1.31.89.5-0.6-0.30.50.9-0.31.70.4-3.11.31.31.92.10.5-1.1-1.1
Delta distance traveled before/after self-admin0.80.81.6-1.1-1.10.81.3-1.21.3-0.6-0.70.91.20.80.80.4-0.60.2
Delta ambulatory time before/after self-admin0.10.10.50.10.4-0.4-0.10.3-0.00.5-0.1-0.30.1-0.3-0.3-0.50.10.7
Parametrial fat weight1.32.44.41.41.2-1.3-1.51.2-1.80.71.8-1.9-1.6-2.1-2.0-1.41.61.4
Pavlov. Cond. lever latency1.21.63.21.40.7-1.0-1.10.8-1.11.00.8-1.6-1.2-1.7-1.4-1.31.81.4
Pavlov. Cond. magazine entry latency0.10.10.4-0.50.20.3-0.00.1-0.1-0.20.10.20.30.20.00.6-0.5-0.6
Pavlov. Cond. change in total contacts0.50.51.2-0.9-0.00.40.4-0.00.4-0.2-0.70.90.71.00.70.9-1.1-1.0
Pavlov. Cond. index score0.30.41.2-0.8-0.00.40.3-0.10.2-0.4-0.10.70.50.70.50.9-1.1-1.0
Pavlov. Cond. latency score0.50.61.8-1.0-0.20.60.4-0.30.4-0.6-0.11.00.61.00.71.1-1.4-1.2
Pavlov. Cond. lever contacts1.11.22.6-1.3-0.60.90.9-0.70.9-0.8-0.61.50.91.51.21.2-1.6-1.3
Pavlov. Cond. magazine entry number0.10.10.40.1-0.40.10.4-0.40.6-0.0-0.60.20.30.30.4-0.30.20.3
Pavlov. Cond. intertrial magazine entries1.11.47.70.10.8-0.7-0.10.70.81.3-2.80.60.71.41.8-0.0-1.3-1.1
Pavlov. Cond. lever-magazine prob. diff.0.20.30.9-0.70.00.30.30.00.3-0.3-0.30.70.50.70.50.8-0.9-0.8
Pavlov. Cond. response bias0.10.10.3-0.50.10.10.00.00.0-0.1-0.00.40.20.40.10.4-0.5-0.5
Pavlov. Cond. lever latency0.81.15.9-0.4-1.21.00.4-1.1-0.3-1.92.40.5-0.4-0.1-0.31.0-0.7-0.9
Pavlov. Cond. magazine entry latency0.00.00.10.4-0.30.10.1-0.30.0-0.20.1-0.0-0.2-0.00.30.1-0.2-0.1
Pavlov. Cond. change in total contacts0.30.42.70.30.9-0.6-0.20.70.11.2-1.6-0.30.20.10.3-0.40.30.3
Pavlov. Cond. index score0.40.52.10.71.0-0.9-0.50.9-0.11.3-1.4-0.5-0.1-0.00.2-0.70.20.4
Pavlov. Cond. latency score0.40.52.40.60.8-0.7-0.30.70.11.2-1.6-0.40.10.10.4-0.60.20.3
Pavlov. Cond. lever contacts0.50.64.4-0.10.7-0.5-0.00.60.61.2-2.1-0.20.70.30.5-0.70.40.6
Pavlov. Cond. magazine entry number0.10.20.4-0.10.4-0.2-0.40.6-0.50.30.4-0.4-0.1-0.5-0.7-0.30.50.3
Pavlov. Cond. intertrial magazine entries0.60.81.60.31.2-1.0-0.81.2-0.71.2-0.2-0.9-0.4-0.8-0.7-1.10.60.9
Pavlov. Cond. lever-magazine prob. diff.0.40.51.90.71.0-0.8-0.50.9-0.11.2-1.4-0.5-0.1-0.00.2-0.70.30.4
Pavlov. Cond. response bias0.30.52.00.40.8-0.8-0.40.70.11.2-1.4-0.50.1-0.10.1-0.80.50.6
Time in closed arm before self-admin2.83.24.7-2.1-1.51.42.0-1.62.1-0.8-2.12.02.22.02.01.3-1.8-1.0
Time in closed arm after self-admin0.10.10.3-0.3-0.30.50.2-0.00.4-0.1-0.30.40.40.40.4-0.1-0.60.0
Time in open arm before self-admin0.60.74.20.4-0.50.7-0.2-0.3-0.7-1.22.00.2-0.8-0.0-0.20.9-0.8-1.0
Time in open arm after self-admin0.10.10.80.3-0.0-0.1-0.0-0.3-0.3-0.30.40.2-0.50.20.10.7-0.3-0.9
Bone: periosteal estimation2.44.912.32.33.5-2.7-2.83.4-2.03.5-1.4-2.1-1.5-1.1-0.5-1.80.20.2
Bone: periosteal perimeter1.93.28.32.22.9-1.9-2.22.8-1.62.8-1.0-1.5-1.5-0.6-0.3-1.20.10.0
Bone: post-yield work1.31.84.31.52.0-1.6-1.72.1-1.41.70.0-1.2-1.4-0.8-0.8-1.30.40.6
Progressive ratio test 1 active lever presses4.54.77.7-2.5-2.02.32.5-2.12.8-1.3-2.32.32.72.42.31.6-1.4-1.1
Progressive ratio test 1 breakpoint4.95.18.2-2.6-2.02.32.5-2.02.8-1.3-2.62.42.92.52.51.8-1.6-1.3
Progressive ratio test 1 inactive lever presses3.03.37.6-2.2-1.01.61.9-1.02.5-0.6-2.81.92.32.22.01.0-1.5-0.2
Progressive ratio test 2 active lever presses0.20.20.6-0.1-0.50.20.5-0.50.7-0.1-0.80.40.60.40.50.2-0.1-0.1
Progressive ratio test 2 breakpoint0.10.10.4-0.1-0.40.20.5-0.40.5-0.1-0.60.30.60.30.30.2-0.0-0.0
Progressive ratio test 2 inactive lever presses0.40.51.20.90.7-0.9-0.50.70.11.0-0.9-0.4-0.1-0.2-0.0-1.10.31.0
Incentive Sensitization - Responses0.60.61.61.30.6-1.0-0.80.6-0.90.60.4-0.8-0.8-0.8-0.7-0.50.70.3
Incentive Sensitization - Breakpoint0.70.71.91.40.6-1.0-0.90.7-1.00.60.6-0.9-0.9-0.9-0.8-0.50.70.3
Sum of active levers in priming session hrs 5-60.70.71.8-0.5-0.81.00.7-0.70.5-1.20.00.70.60.60.71.0-1.4-1.0
Progressive ratio0.91.12.51.30.9-0.6-1.20.8-1.40.71.6-1.0-1.5-1.1-1.1-0.50.40.3
Food seeking constrained by brief footshock1.11.32.61.01.4-1.0-1.41.6-1.30.90.9-1.1-1.2-1.1-1.3-0.91.00.5
Seeking ratio, punishment vs. effort0.20.21.2-0.7-0.2-0.00.4-0.00.7-0.1-1.10.40.80.60.50.0-0.0-0.1
Retroperitoneal fat weight2.37.616.1-3.1-2.12.82.3-2.11.6-3.0-0.23.02.02.82.43.4-4.0-4.0
Reaction time number correct0.30.51.60.80.5-0.8-0.60.4-0.21.0-0.3-0.7-0.5-0.5-0.4-1.01.30.8
Reaction time mean minus median0.50.64.20.6-0.1-0.0-0.60.1-1.1-0.82.0-0.5-0.9-0.9-1.0-0.1-0.0-0.2
Reaction time mean minus median AUC0.70.91.80.90.7-0.8-0.90.9-1.10.41.0-1.1-0.8-1.3-1.3-0.91.20.7
Reaction time num false alarms0.60.95.0-0.20.7-0.4-0.10.60.71.1-2.20.40.61.11.40.0-1.0-0.8
Reaction time num false alarms AUC0.60.84.50.11.1-0.9-0.51.00.31.5-2.1-0.10.20.61.0-0.5-0.6-0.3
Reaction time trials correct on left0.30.51.60.80.5-0.8-0.60.4-0.21.0-0.3-0.7-0.5-0.5-0.4-1.01.30.8
Reaction time trials on left0.40.61.80.90.6-0.8-0.70.5-0.41.0-0.2-0.8-0.6-0.7-0.6-1.11.30.9
Reaction time mean1.01.44.80.90.4-0.7-0.90.6-1.5-0.52.2-1.2-1.1-1.7-1.8-0.51.10.8
Reaction time mean AUC0.71.04.00.60.2-0.4-0.60.3-1.2-0.72.0-0.9-0.8-1.4-1.6-0.31.00.7
Median of all reaction times1.01.43.60.80.6-0.8-0.90.6-1.4-0.21.9-1.3-1.0-1.7-1.8-0.51.31.0
Reaction time omissions0.81.22.40.70.9-0.8-0.90.9-1.20.31.5-1.2-0.9-1.5-1.5-1.11.01.0
Reaction time false alarm rate0.40.52.3-0.30.6-0.3-0.10.50.30.6-1.50.40.40.81.10.2-1.2-0.8
Reaction time premature initiation rate0.81.13.1-0.9-0.21.10.7-0.30.8-0.6-0.71.00.81.21.31.3-1.8-1.6
Reaction time premature initiations0.20.20.8-0.20.40.40.10.20.40.2-0.90.30.40.60.70.4-0.6-0.7
Std. dev. reaction times1.21.65.71.20.5-0.6-1.00.7-1.6-0.42.4-1.3-1.3-1.8-1.9-0.81.00.9
Reaction time trials completed0.40.61.80.90.6-0.8-0.70.5-0.41.0-0.2-0.8-0.6-0.7-0.6-1.11.30.9
Reaction time trials AUC0.40.51.70.80.5-0.7-0.60.4-0.40.9-0.0-0.7-0.6-0.7-0.6-1.01.30.8
Run reversals in cocaine runway, females3.83.67.7-1.4-2.12.31.0-1.80.2-2.82.31.70.31.20.92.4-2.7-2.7
Run reversals in cocaine runway, males0.60.61.20.90.7-0.7-0.80.8-1.00.31.1-0.7-1.1-0.8-0.7-0.90.00.6
Latency to leave start box in cocaine runway6.16.69.8-3.0-3.13.02.8-3.12.5-2.9-0.72.62.82.22.22.9-1.7-2.0
Latency to leave start box in cocaine runway, F6.26.811.2-2.9-2.73.12.7-2.92.4-2.7-0.72.82.42.62.43.3-2.0-2.6
Latency to leave start box in cocaine runway, M1.91.83.8-1.8-2.01.61.6-1.91.3-1.9-0.01.11.70.60.61.0-0.5-0.4
Std. dev. time between licks in bursts0.60.71.6-0.9-1.20.90.8-1.10.6-1.30.60.80.40.50.30.9-0.5-0.5
Total sessions with >9 infusions2.02.28.2-1.2-0.91.01.5-0.82.10.1-2.91.51.92.01.80.8-0.6-0.2
Short access day 1 total inactive lever presses0.20.20.8-0.2-0.20.00.5-0.20.60.2-0.90.50.30.70.70.1-0.2-0.0
Short access day 10 total inactive lever presses0.20.20.40.40.5-0.6-0.50.6-0.40.5-0.1-0.5-0.4-0.3-0.2-0.40.10.2
Short access day 1 total infusions2.83.08.3-1.7-1.51.22.0-1.42.5-0.3-2.91.72.12.12.10.8-0.5-0.2
Short access day 10 total infusions2.83.17.3-1.7-1.11.41.7-1.12.5-0.5-2.72.02.32.32.31.0-1.3-0.5
Short access total infusions2.02.210.0-1.3-0.70.71.4-0.72.20.4-3.21.42.01.81.90.3-0.40.1
Short access day 1 locomotion2.52.75.9-2.0-1.01.41.8-1.12.1-0.3-2.41.82.12.01.81.3-1.1-0.8
Short access day 10 total locomotion0.80.82.6-0.40.10.40.40.00.90.3-1.51.00.71.41.40.4-1.6-0.7
Short access total locomotion3.23.35.7-2.1-1.11.61.8-1.12.3-0.6-2.42.12.12.42.31.3-2.0-0.9
One hour access (0.3 mA shock)0.70.82.21.01.2-1.0-0.71.2-0.01.4-1.5-0.80.2-0.4-0.2-0.90.90.7
Compulsive drug intake1.61.62.81.51.6-1.6-1.61.7-1.41.4-0.1-1.5-1.1-1.2-1.0-1.00.80.3
One hour access (shock baseline)0.10.10.70.20.3-0.2-0.00.20.20.2-0.1-0.10.1-0.1-0.1-0.70.10.8
Social response proportion1.51.62.61.41.4-1.3-1.61.5-1.60.81.2-1.3-1.5-1.3-1.2-1.40.40.7
Social responses0.30.31.4-0.60.00.10.3-0.10.6-0.1-1.20.40.70.70.80.1-0.9-0.5
Social time1.82.43.81.81.8-1.8-1.91.7-1.81.31.0-1.4-1.9-1.3-1.5-1.60.71.1
Soleus weight0.10.30.80.30.7-0.4-0.60.7-0.20.7-0.30.2-0.50.60.5-0.3-0.9-0.6
Bone: stiffness0.40.71.40.81.1-0.9-1.11.0-1.20.80.5-0.9-0.9-0.8-0.6-0.6-0.10.0
Tibialis anterior weight0.51.84.3-1.2-1.01.20.9-0.90.8-1.40.11.70.71.61.21.6-2.1-2.1
Time to tail flick, vehicle, before self-admin1.31.33.21.50.7-0.8-1.40.8-1.50.31.8-1.2-1.6-1.3-1.2-0.70.60.6
Time to tail flick, vehicle, after self-admin2.32.54.42.11.7-1.4-1.91.7-1.91.41.3-1.7-1.9-1.6-1.5-1.11.00.6
Time to tail flick, test, before self-admin2.92.86.41.92.0-2.0-2.11.8-2.51.11.8-1.5-2.1-1.6-1.4-0.8-0.2-0.1
Time to tail flick, test, after self-admin1.61.63.01.51.7-1.5-1.51.5-1.21.50.1-1.4-1.1-1.2-0.8-1.30.71.0
Delta time to tail flick, vehicle, before/after SA1.61.52.61.31.6-1.3-1.31.5-1.21.50.2-1.4-0.9-1.2-1.3-1.11.30.9
Delta time to tail flick, test, before/after SA1.31.12.31.01.2-1.0-0.91.1-0.41.5-0.6-1.1-0.6-0.8-0.7-1.41.41.4
Tibia length0.71.95.5-1.0-0.91.30.9-0.90.6-1.4-0.11.50.81.51.41.9-2.3-2.3
Ambulatory time before self-admin0.60.61.8-0.3-1.01.20.4-0.80.2-1.30.90.50.00.30.40.6-1.0-0.9
Ambulatory time after self-admin0.30.31.1-0.5-0.60.70.3-0.60.0-1.00.70.30.00.10.10.6-1.0-0.5
Bone: tissue strength0.40.40.8-0.6-0.80.50.8-0.80.9-0.4-0.70.40.60.40.40.10.40.4
Total heroin consumption0.10.10.30.10.2-0.3-0.30.2-0.3-0.10.4-0.5-0.3-0.5-0.3-0.50.00.3
Bone: trabecular number4.47.011.02.12.7-3.2-2.42.5-2.03.10.3-2.8-2.0-2.6-2.5-3.33.23.2
Bone: trabecular spacing2.73.56.0-1.4-2.22.51.8-2.01.3-2.50.31.81.41.41.52.4-2.2-2.1
Bone: trabecular thickness1.51.84.81.01.9-1.8-1.41.6-0.92.2-0.7-1.2-0.8-0.7-0.5-1.80.91.1
Bone: trabecular tissue density1.11.64.0-0.8-1.61.61.1-1.60.6-2.00.71.10.80.70.81.8-1.4-1.4
Water consumed over 24 hours3.03.66.3-2.5-2.32.12.2-2.12.1-2.0-0.81.92.11.71.61.7-1.3-1.2
Number of responses in last shaping day2.93.04.2-1.5-1.72.02.0-1.82.1-1.4-1.12.01.72.01.91.3-1.8-0.7