Hub : Genes

LOC100912167

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	mRNA stability	LOC100912167	0.29	0.23	2.0e-03	0.01	0.01	0.02	0.03	1.2e-02	7.4e-03	2.4e-03	8.9e-04
2	PL	gene expression	LOC100912167	0.07	0.04	1.2e-05	0.05	0.04	0.04	0.04	6.4e-06	5.9e-05	2.1e-05	2.0e-05
3	Brain	gene expression	LOC100912167	0.05	0.04	7.8e-03	0.03	0.02	0.04	0.03	1.7e-03	1.2e-02	1.6e-04	1.4e-03
4	BLA	gene expression	LOC100912167	0.08	0.06	2.0e-03	0.03	0.01	0.02	0.01	7.7e-03	9.7e-02	3.2e-02	8.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.0	0.1	0.1	-0.0	0.2	0.2	0.4
Area under the delay curve	1.2	1.2	2.0	-1.4	0.8	0.9	1.3
BMI with tail	0.0	0.1	0.1	0.3	-0.2	-0.2	0.4
BMI without tail	0.3	0.7	2.6	1.6	-0.2	-0.3	-0.0
Body weight	2.4	9.9	17.8	4.2	-2.8	-2.9	-2.3
Weight adjusted by age	2.6	2.9	4.4	2.1	-1.5	-1.6	-1.5
Bone surface	0.2	0.3	0.5	0.7	-0.4	-0.4	-0.6
Bone volume	0.1	0.1	0.2	0.4	-0.2	-0.2	-0.3
Breakpoint value in progressive ratio session	1.6	1.8	2.8	0.5	-1.7	-1.6	-1.3
Number of licking bursts	0.1	0.1	0.2	0.5	0.4	0.4	0.0
Context. condit. distance diff. score	0.5	0.6	1.0	-0.4	1.0	1.0	0.5
Locomotion velocity, session 1	0.3	0.3	1.2	-1.1	0.1	0.1	0.1
Locomotion distance, session 1	3.5	4.5	4.9	-2.1	2.2	2.2	2.0
Locomotion velocity, session 2	1.9	2.2	4.8	-2.2	1.4	1.4	0.5
Locomotion distance, session 2	1.2	1.7	2.2	-1.1	1.5	1.5	1.1
Locomotion velocity, session 3	0.3	0.4	1.0	-1.0	0.4	0.5	0.2
Locomotion distance, session 3	1.7	1.9	4.3	-2.1	1.1	1.2	0.7
Stereotopy head waving bouts, day 3	0.0	0.0	0.1	-0.4	0.1	0.0	-0.2
Stereotopy head waving duration, day 3	0.1	0.1	0.1	-0.4	0.3	0.3	-0.1
Locomotion velocity, session 7	0.6	0.7	1.2	-1.1	0.8	0.8	0.5
Locomotion distance, session 7	5.3	6.7	8.0	-2.8	2.6	2.6	2.3
Stereotopy head waving bouts, day 7	0.2	0.2	0.5	0.4	-0.4	-0.3	-0.7
Stereotopy head waving duration, day 7	0.9	1.1	2.2	1.2	-0.7	-0.6	-1.5
Locomotion velocity, session 8	1.5	1.8	2.6	-1.1	1.6	1.6	0.8
Locomotion distance, session 8	2.1	3.1	4.5	-1.1	2.1	2.1	1.6
Degree of sensitization distance	0.2	0.2	0.4	0.1	0.5	0.5	0.6
Degree of sensitization stereotypy	0.3	0.3	0.7	0.6	-0.4	-0.4	-0.8
Conditioned locomotion	0.8	0.9	2.8	1.7	-0.7	-0.6	-0.2
Cocaine response after cond. corrected	0.2	0.2	0.3	-0.3	-0.6	-0.6	0.3
Cocaine response after cond. not corrected	0.2	0.2	0.6	-0.8	-0.1	-0.1	0.4
Cocaine response before conditioning	0.7	0.9	1.3	-0.9	1.2	1.1	0.3
Saline control response	2.2	2.8	4.7	2.2	-1.5	-1.5	-1.4
Bone: connectivity density	0.3	0.5	0.8	-0.5	0.9	0.9	0.4
Bone: cortical apparent density	1.5	1.9	3.9	-2.0	0.8	0.9	1.6
Bone: cortical area	6.0	9.1	12.5	3.5	-2.9	-3.0	-2.5
Bone: cortical porosity	4.4	4.8	7.1	1.4	-2.6	-2.7	-1.8
Bone: cortical porosity	3.7	4.1	5.8	1.4	-2.4	-2.4	-1.6
Bone: cortical thickness	6.4	10.5	12.4	3.5	-3.3	-3.3	-2.7
Bone: cortical thickness	1.9	2.2	2.9	1.6	-1.7	-1.7	-0.8
Bone: cortical tissue density	1.7	2.2	4.4	-2.1	0.9	0.9	1.7
Condit. Reinf. active minus inactive responses	1.1	1.2	1.9	1.4	-1.0	-1.1	-0.9
Condit. Reinf. active-inactive response ratio	0.3	0.4	0.5	0.6	-0.7	-0.7	-0.3
Condit. Reinf. active responses	2.0	2.4	4.3	2.1	-1.3	-1.4	-1.3
Condit. Reinf. inactive responses	0.6	0.7	1.2	1.1	-0.6	-0.7	-0.9
Incentive salience index mean	1.0	1.2	2.1	1.5	-0.8	-0.8	-1.1
Condit. Reinf. lever presses	0.1	0.2	0.3	0.1	0.5	0.5	-0.2
Condit. Reinf. active minus inactive responses	0.4	0.5	1.1	1.0	-0.4	-0.4	-0.6
Condit. Reinf. active-inactive response ratio	2.5	2.6	3.5	1.9	-1.6	-1.5	-1.4
Condit. Reinf. active responses	0.0	0.1	0.1	0.0	0.3	0.3	0.3
Condit. Reinf. inactive responses	1.4	1.7	1.9	-1.4	1.3	1.2	1.3
Condit. Reinf. lever presses	0.4	0.5	1.3	-0.4	0.5	0.6	1.1
Condit. Reinf. lever reinforcers received	0.2	0.3	0.6	-0.3	0.5	0.4	0.8
Conditioned reinforcement - actives	0.1	0.1	0.2	0.4	0.4	0.2	0.2
Conditioned reinforcement - inactives	1.6	1.8	2.1	1.4	-1.3	-1.4	-1.1
Conditioned locomotion	0.4	0.5	1.0	1.0	-0.5	-0.5	-0.6
Patch foraging indifference point 0 sec	0.0	0.0	0.1	0.3	0.0	-0.1	-0.3
Patch foraging indifference point AUC	0.1	0.1	0.3	-0.0	0.4	0.4	0.5
Delay disc. indifference point, 0s delay	0.1	0.1	0.2	0.1	0.0	0.1	0.4
Delay disc. indifference point, 16s delay	4.2	4.3	5.1	-1.9	2.1	2.1	2.3
Delay disc. indifference point, 2s delay	0.1	0.1	0.1	-0.3	-0.3	-0.3	0.0
Delay disc. indifference point, 24s delay	1.6	1.6	3.9	-2.0	0.8	0.9	1.0
Delay disc. indifference point, 4s delay	0.1	0.1	0.5	-0.7	0.0	-0.1	0.2
Delay disc. indifference point, 8s delay	0.1	0.1	0.4	-0.7	-0.1	-0.0	0.2
Indifference point function ln k	0.8	1.2	2.3	-1.5	0.9	0.9	0.7
Indifference point function log k	0.8	1.2	2.3	-1.5	0.9	0.9	0.7
Patch foraging total patch changes 0 sec	0.0	0.0	0.0	0.0	0.1	0.0	-0.0
Patch foraging total patch changes 12 sec	0.0	0.0	0.0	0.2	0.0	-0.1	-0.1
Patch foraging total patch changes 18 sec	1.3	1.6	2.2	-1.0	1.3	1.3	1.5
Patch foraging total patch changes 24 sec	0.3	0.4	1.2	1.1	-0.5	-0.5	0.0
Patch foraging total patch changes 6 sec	0.6	0.9	1.4	1.2	-0.9	-0.9	-0.9
Patch foraging time to switch 0 sec	0.2	0.3	1.0	-1.0	0.3	0.3	0.5
Patch foraging water rate 0 sec	0.7	1.1	3.2	1.8	-0.5	-0.5	-0.7
Patch foraging water rate 12 sec	0.4	0.6	0.9	-0.4	1.0	0.8	0.8
Patch foraging water rate 18 sec	0.2	0.2	0.5	0.7	0.5	0.4	0.0
Patch foraging water rate 24 sec	0.2	0.3	0.8	0.4	0.3	0.4	0.9
Patch foraging water rate 6 sec	0.0	0.0	0.1	0.1	0.3	0.3	-0.2
Seeking ratio, delayed vs. immediate footshock	1.1	1.3	1.9	1.4	-1.0	-1.0	-1.2
Distance traveled before self-admin	2.4	2.6	4.6	1.0	-1.6	-1.5	-2.1
Distance traveled after self-admin	0.1	0.1	0.1	0.2	0.3	0.3	-0.3
Extensor digitorum longus weight	0.4	1.8	2.8	-0.9	1.3	1.3	1.7
Bone: elastic displacement	1.3	1.5	2.1	1.4	-1.3	-1.3	-0.6
Bone: elastic work	8.7	11.3	12.9	3.6	-3.6	-3.6	-2.6
Bone: endosteal estimation	0.3	0.7	0.9	-0.5	0.9	1.0	0.9
Bone: endosteal perimeter	0.6	1.3	2.2	1.5	-1.0	-1.0	-1.1
Epididymis fat weight	0.3	0.7	2.0	1.4	-0.6	-0.6	-0.1
Delta time in closed arm before/after self-admin	0.2	0.2	0.5	0.7	0.4	0.4	-0.1
Delta time in open arm before/after self-admin	0.1	0.1	0.2	-0.2	0.3	0.4	0.5
Diff in mean of infusions in LGA sessions	0.1	0.1	0.4	-0.0	-0.3	-0.2	-0.7
Delay discount exponential model param	1.3	1.3	2.7	1.6	-0.7	-0.8	-1.2
Extinction: sum of active levers before priming	0.6	0.6	1.7	-1.3	0.5	0.5	0.3
Active lever presses in extinction session 6	0.9	0.9	1.6	0.2	-1.3	-1.2	-0.7
Bone: final force	4.3	7.0	10.3	3.2	-2.6	-2.6	-2.1
Bone: final moment	5.3	8.6	12.0	3.5	-2.9	-2.9	-2.3
Food consumed during 24 hour testing period	0.2	0.3	0.6	0.8	-0.4	-0.5	-0.5
Glucose	0.8	1.1	2.6	-1.6	-1.0	-1.0	-0.2
Heart weight	0.2	0.3	0.5	0.7	-0.6	-0.4	0.4
Delay discount hyperbolic model param	1.2	1.2	2.6	1.6	-0.7	-0.7	-1.1
Intermittent access intake day 1-15 change	0.2	0.2	0.4	0.2	-0.6	-0.5	-0.3
Intermittent access intake escalation	0.2	0.2	0.2	0.3	-0.5	-0.4	-0.4
Intermittent access intake escalation 2	3.4	3.4	4.3	0.9	-2.1	-2.1	-2.1
Intermitt. access day 1 inactive lever presses	1.9	2.0	3.0	1.7	-1.6	-1.2	-1.1
Intermitt. access day 15 inactive lever presses	0.4	0.5	1.1	1.0	-0.4	-0.4	-0.6
Intermitt. access escalation Index	0.6	0.5	1.8	1.3	0.4	0.4	0.0
Intermittent access day 1 total infusions	0.1	0.1	0.2	0.4	-0.0	-0.2	0.2
Intermittent access day 15 total infusions	0.1	0.2	0.5	0.7	-0.2	-0.3	0.1
Intermittent access terminal intake (last 3 days)	0.6	0.6	1.0	1.0	-0.7	-0.9	-0.5
Intermittent access total infusions	0.1	0.1	0.4	0.7	-0.2	-0.4	-0.1
Intermittent access day 1 locomotion	0.2	0.2	0.7	0.9	-0.3	-0.3	0.2
Intermittent access day 15 total locomotion	0.6	0.7	0.9	0.8	-1.0	-0.9	-0.6
Intermittent access total locomotion	0.5	0.5	0.9	0.9	-0.8	-0.7	-0.4
Intermittent access standard deviation	0.7	0.8	1.1	-0.4	-1.1	-1.0	-0.9
Left kidney weight	0.6	1.5	2.6	1.6	-1.1	-1.2	-0.9
Right kidney weight	0.1	0.4	1.3	1.1	-0.3	-0.3	-0.1
Cocaine induced anxiety	7.7	8.8	9.5	2.7	-3.1	-3.1	-3.0
Post-drug Anxiety	1.7	1.9	2.5	0.7	-1.5	-1.6	-1.6
Baseline Anxiety	6.6	7.0	9.6	-3.1	2.5	2.5	2.5
Tail length	2.5	7.6	19.2	4.4	-1.8	-1.9	-2.1
Length with tail	3.0	11.2	19.4	4.4	-2.9	-3.0	-2.8
Length without tail	1.3	2.8	3.5	1.4	-1.9	-1.8	-1.5
Times rat made contact with spout	2.7	3.1	3.4	1.7	-1.8	-1.8	-1.9
Lifetime Intake	0.0	0.0	0.1	0.3	-0.0	-0.2	-0.1
Liver weight, left	0.3	0.5	0.8	0.4	-0.9	-0.9	-0.4
Liver weight, right	2.9	4.9	8.2	2.9	-1.6	-1.6	-2.5
Locomotor activity	0.3	0.4	1.0	-1.0	0.4	0.4	0.5
Locomotor testing distance	0.5	0.9	1.5	-1.0	0.7	0.7	1.2
Locomotor testing rearing	0.4	0.6	0.8	-0.6	0.8	0.8	0.9
Locomotion in novel chamber	0.6	0.8	1.2	-0.1	1.1	1.1	0.8
Locomotion in novel chamber post-restriction	0.8	1.0	1.5	1.2	-1.0	-0.9	-0.8
Fecal boli incidents, locomotor time 1	0.4	0.5	0.6	-0.8	0.6	0.7	0.6
Change in fecal boli incidents, locomotor task	1.1	1.0	3.6	-1.9	-0.2	-0.2	-0.6
Time >=10cm from walls, locomotor time 1	0.8	0.8	1.2	-0.6	1.1	1.1	0.8
Bouts of movement, locomotor time 1	1.2	1.3	2.4	-1.5	1.1	0.8	1.1
Total resting periods, locomotor time 1	1.0	1.1	2.4	-1.6	0.9	0.6	1.0
Rest time, locomotor task time 1	0.1	0.2	0.4	-0.0	-0.5	-0.6	-0.2
Distance moved, locomotor task time 1	0.2	0.2	0.5	0.7	0.1	0.4	0.5
Vertical activity count, locomotor time 1	0.2	0.2	0.5	0.7	0.3	0.5	0.3
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.0	0.2	0.1	0.1	-0.1
Bouts of movement, locomotor time 2	1.6	1.8	2.1	-1.4	1.3	1.2	1.5
Total resting periods, locomotor time 2	1.6	1.7	2.0	-1.1	1.4	1.2	1.4
Rest time, locomotor task time 2	0.0	0.0	0.0	-0.1	0.1	0.1	0.1
Distance moved, locomotor task time 2	0.1	0.1	0.2	0.4	0.0	0.2	0.4
Vertical activity count, locomotor time 2	0.4	0.4	0.7	0.1	0.7	0.7	0.8
Light reinforcement 1	0.3	0.5	1.5	1.2	0.3	0.2	0.5
Light reinforcement 2	1.1	1.5	3.8	1.9	-0.7	-0.8	-1.0
Bone: marrow area	0.3	0.8	0.9	-0.5	1.0	1.0	0.9
Bone: maximum diameter	1.7	3.2	5.2	2.3	-1.4	-1.4	-1.8
Bone: maximum force	3.8	6.5	10.7	3.3	-2.4	-2.4	-2.0
Bone: maximum moment	4.6	7.9	12.2	3.5	-2.7	-2.7	-2.2
Mean time between licks in bursts	1.1	1.6	1.7	-1.3	1.3	1.3	1.2
Mean num. licks in bursts	0.8	1.0	1.5	0.5	-1.2	-1.2	-0.9
Cd content in liver	2.0	2.2	3.3	-1.8	1.3	1.3	1.5
Co content in liver	0.1	0.2	0.3	-0.5	0.2	0.2	0.5
Cu content in liver	1.7	2.0	2.7	0.7	-1.6	-1.5	-1.6
Fe content in liver	0.9	1.1	1.4	-1.0	1.0	1.0	1.2
K content in liver	0.8	0.8	2.5	1.6	-0.4	-0.3	-0.6
Mg content in liver	0.7	0.7	1.4	-0.0	1.1	1.2	0.6
Mn content in liver	0.5	0.5	1.1	0.8	-0.4	-0.4	-1.1
Na content in liver	0.1	0.1	0.3	0.4	-0.1	-0.1	-0.5
Rb content in liver	0.0	0.1	0.2	0.4	0.1	0.2	-0.0
Se content in liver	0.1	0.1	0.1	0.2	-0.2	-0.3	-0.3
Sr content in liver	1.0	0.9	1.4	0.1	-1.2	-1.2	-0.9
Zn content in liver	0.3	0.3	0.7	0.7	-0.2	-0.1	-0.9
Bone: minimum diameter	3.4	6.3	8.0	2.8	-2.5	-2.5	-2.3
Time in familiar zone, hab. session 1	0.2	0.2	0.2	-0.4	-0.4	-0.4	0.4
Time in novel zone, hab. session 1	0.1	0.1	0.2	0.1	0.4	0.4	-0.2
Total zone transitions, hab. session 1	0.7	1.0	1.5	-1.0	0.8	0.8	1.2
Total locomotion distance, hab. session 1	0.1	0.2	0.3	-0.1	0.4	0.4	0.6
Locomotion velocity, hab. session 1	0.1	0.1	0.2	0.0	0.4	0.4	0.5
Time in familiar zone, hab. session 2	0.5	0.5	1.0	-0.7	0.5	0.5	1.0
Time in novel zone, hab. session 2	0.0	0.0	0.1	-0.1	0.3	0.3	-0.2
Total zone transitions, hab. session 2	2.0	2.5	3.3	-1.2	1.8	1.8	1.5
Total locomotion distance, hab. session 2	0.6	0.8	1.5	-0.0	1.2	1.2	0.6
Locomotion velocity, hab. session 2	0.4	0.5	1.0	0.3	1.0	1.0	0.4
Novel to familiar place preference ratio	3.4	3.5	4.7	1.2	-2.2	-2.2	-1.8
Novelty place preference	3.5	3.6	4.7	1.2	-2.2	-2.2	-1.8
Time in novel zone, NPP test	2.5	2.6	3.5	1.0	-1.9	-1.9	-1.6
Total zone transitions, NPP test	3.0	4.3	5.3	-1.3	2.3	2.3	2.2
Total locomotion distance, NPP test	1.7	2.3	3.4	-0.7	1.8	1.8	1.5
Locomotion velocity, NPP test	0.9	1.3	1.8	-0.4	1.4	1.3	1.2
Intraocular pressure	0.1	0.1	0.2	0.1	-0.4	-0.4	0.0
Delta distance traveled before/after self-admin	1.9	2.0	2.7	-0.8	1.5	1.5	1.7
Delta ambulatory time before/after self-admin	2.7	2.9	3.8	-1.2	1.8	1.8	2.0
Parametrial fat weight	1.1	2.2	4.1	2.0	-1.5	-1.3	-0.8
Pavlov. Cond. lever latency	3.9	4.9	7.6	-2.1	1.9	2.0	2.8
Pavlov. Cond. magazine entry latency	4.5	5.8	6.3	2.4	-2.5	-2.5	-2.2
Pavlov. Cond. change in total contacts	1.8	2.0	2.9	0.7	-1.7	-1.7	-1.3
Pavlov. Cond. index score	5.4	6.8	8.5	2.9	-2.4	-2.4	-2.7
Pavlov. Cond. latency score	5.5	6.9	8.7	2.8	-2.4	-2.4	-2.9
Pavlov. Cond. lever contacts	2.3	2.8	4.3	1.8	-1.3	-1.3	-2.1
Pavlov. Cond. magazine entry number	5.0	6.3	7.5	-2.3	2.7	2.7	2.2
Pavlov. Cond. intertrial magazine entries	0.3	0.3	0.9	-0.2	0.5	0.5	0.9
Pavlov. Cond. lever-magazine prob. diff.	5.4	6.7	8.1	2.9	-2.5	-2.5	-2.6
Pavlov. Cond. response bias	4.7	5.7	5.9	2.4	-2.4	-2.4	-2.3
Pavlov. Cond. lever latency	0.4	0.5	1.0	-0.1	-0.8	-0.8	-1.0
Pavlov. Cond. magazine entry latency	3.9	4.4	4.6	-2.1	2.1	2.1	2.2
Pavlov. Cond. change in total contacts	1.7	2.3	3.6	-1.3	1.4	1.4	1.9
Pavlov. Cond. index score	1.5	1.9	3.4	-1.1	1.3	1.3	1.8
Pavlov. Cond. latency score	1.5	1.9	3.0	-1.0	1.3	1.3	1.7
Pavlov. Cond. lever contacts	0.5	0.7	1.2	0.3	0.9	0.9	1.1
Pavlov. Cond. magazine entry number	3.4	4.2	5.0	1.9	-2.0	-2.0	-2.2
Pavlov. Cond. intertrial magazine entries	0.9	1.2	2.5	1.6	-0.9	-0.9	-0.7
Pavlov. Cond. lever-magazine prob. diff.	1.8	2.3	3.8	-1.3	1.4	1.4	2.0
Pavlov. Cond. response bias	1.1	1.5	2.3	-0.6	1.3	1.3	1.5
Time in closed arm before self-admin	0.3	0.3	0.7	-0.9	-0.5	-0.5	-0.2
Time in closed arm after self-admin	0.4	0.4	0.5	-0.5	-0.7	-0.6	-0.6
Time in open arm before self-admin	0.1	0.1	0.3	0.6	0.2	0.2	-0.3
Time in open arm after self-admin	0.3	0.4	0.6	-0.1	0.7	0.8	0.5
Bone: periosteal estimation	1.1	2.3	4.1	2.0	-1.4	-1.4	-1.2
Bone: periosteal perimeter	5.0	8.2	10.1	3.2	-2.8	-2.8	-2.7
Bone: post-yield work	0.4	0.6	0.9	-0.2	0.9	0.9	0.7
Progressive ratio test 1 active lever presses	0.4	0.4	1.0	1.0	-0.3	-0.6	-0.3
Progressive ratio test 1 breakpoint	0.4	0.4	1.2	1.1	-0.3	-0.6	-0.3
Progressive ratio test 1 inactive lever presses	1.0	1.1	3.4	1.8	-0.6	-0.5	-0.5
Progressive ratio test 2 active lever presses	0.3	0.4	0.6	0.8	-0.7	-0.6	-0.2
Progressive ratio test 2 breakpoint	0.2	0.2	0.6	0.8	-0.4	-0.4	-0.0
Progressive ratio test 2 inactive lever presses	0.7	0.8	1.0	0.9	-0.9	-1.0	-0.7
Incentive Sensitization - Responses	0.2	0.2	0.4	0.4	-0.4	0.0	0.6
Incentive Sensitization - Breakpoint	0.2	0.2	0.3	0.4	-0.5	-0.1	0.5
Sum of active levers in priming session hrs 5-6	1.5	1.5	2.0	0.2	-1.4	-1.4	-1.4
Progressive ratio	0.1	0.2	0.6	-0.8	0.2	0.1	-0.0
Food seeking constrained by brief footshock	0.2	0.2	0.3	-0.4	-0.5	-0.5	-0.3
Seeking ratio, punishment vs. effort	0.0	0.0	0.1	0.3	0.0	0.1	0.3
Retroperitoneal fat weight	2.3	7.4	17.2	4.1	-2.4	-2.2	-1.3
Reaction time number correct	4.3	6.2	8.5	-0.9	2.8	2.7	2.9
Reaction time mean minus median	0.1	0.2	0.3	0.1	-0.4	-0.4	-0.5
Reaction time mean minus median AUC	0.2	0.2	0.5	0.7	-0.1	-0.0	-0.5
Reaction time num false alarms	0.3	0.3	0.7	-0.9	0.3	0.4	0.6
Reaction time num false alarms AUC	0.6	0.8	1.5	-1.2	0.6	0.7	0.9
Reaction time trials correct on left	4.3	6.2	8.5	-0.9	2.8	2.7	2.9
Reaction time trials on left	4.4	6.3	8.7	-0.9	2.9	2.7	2.9
Reaction time mean	0.1	0.1	0.3	0.0	0.2	0.2	0.6
Reaction time mean AUC	0.2	0.3	0.8	-0.1	0.5	0.5	0.9
Median of all reaction times	0.2	0.3	0.8	-0.2	0.4	0.4	0.9
Reaction time omissions	0.1	0.1	0.2	0.4	0.2	0.4	0.1
Reaction time false alarm rate	0.4	0.5	0.7	-0.7	-0.8	-0.7	-0.8
Reaction time premature initiation rate	0.7	0.9	2.6	-1.6	0.5	0.6	0.6
Reaction time premature initiations	3.0	4.2	4.8	-1.9	2.0	2.0	2.2
Std. dev. reaction times	0.5	0.8	0.8	-0.9	0.8	0.9	0.9
Reaction time trials completed	4.4	6.3	8.7	-0.9	2.9	2.7	2.9
Reaction time trials AUC	4.3	6.1	8.5	-0.9	2.8	2.7	2.9
Run reversals in cocaine runway, females	3.5	3.4	5.0	-1.6	1.7	1.8	2.2
Run reversals in cocaine runway, males	3.3	3.2	4.0	1.1	-2.0	-2.0	-1.9
Latency to leave start box in cocaine runway	0.9	0.9	1.2	-0.8	1.0	0.9	1.1
Latency to leave start box in cocaine runway, F	1.4	1.5	2.2	-0.6	1.3	1.3	1.5
Latency to leave start box in cocaine runway, M	0.0	0.0	0.0	-0.1	-0.0	-0.1	-0.1
Std. dev. time between licks in bursts	1.5	1.8	2.4	0.2	1.5	1.6	1.5
Total sessions with >9 infusions	0.3	0.3	0.5	-0.7	0.6	0.5	0.3
Short access day 1 total inactive lever presses	0.2	0.2	0.5	0.7	0.3	0.3	0.3
Short access day 10 total inactive lever presses	2.7	3.0	4.6	2.1	-1.8	-1.5	-1.5
Short access day 1 total infusions	0.6	0.7	1.4	-1.2	0.9	0.7	0.5
Short access day 10 total infusions	0.6	0.6	0.9	1.0	-0.6	-0.8	-0.8
Short access total infusions	0.0	0.0	0.1	-0.1	0.3	0.1	-0.0
Short access day 1 locomotion	0.1	0.1	0.4	-0.2	-0.1	-0.2	-0.6
Short access day 10 total locomotion	0.6	0.7	1.1	0.1	-1.1	-1.1	-0.6
Short access total locomotion	0.1	0.1	0.2	-0.2	-0.3	-0.4	-0.5
One hour access (0.3 mA shock)	0.2	0.3	0.9	0.9	-0.3	-0.4	0.1
Compulsive drug intake	0.1	0.1	0.4	0.7	-0.2	-0.1	0.3
One hour access (shock baseline)	0.1	0.1	0.5	0.7	0.1	0.0	-0.0
Social response proportion	0.8	0.9	1.0	-0.9	1.0	0.9	0.9
Social responses	0.1	0.1	0.2	-0.2	0.5	0.3	0.3
Social time	0.4	0.5	0.7	-0.6	0.6	0.6	0.9
Soleus weight	0.9	2.5	6.4	2.5	-1.1	-1.1	-1.2
Bone: stiffness	0.4	0.7	1.1	1.0	-0.7	-0.7	-0.7
Tibialis anterior weight	0.1	0.3	0.6	-0.3	0.7	0.7	0.2
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.3	0.5	0.2	0.2	-0.1
Time to tail flick, vehicle, after self-admin	0.8	0.8	1.2	-1.1	0.8	0.9	0.8
Time to tail flick, test, before self-admin	0.3	0.3	0.6	0.1	-0.7	-0.8	-0.5
Time to tail flick, test, after self-admin	0.2	0.2	0.3	-0.2	-0.4	-0.4	-0.5
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	0.5	-0.5	0.6	0.6	0.7
Delta time to tail flick, test, before/after SA	0.2	0.2	0.7	-0.8	0.0	0.0	-0.0
Tibia length	9.5	26.8	38.6	6.2	-5.1	-5.0	-4.2
Ambulatory time before self-admin	3.8	3.9	6.6	1.6	-1.8	-1.8	-2.6
Ambulatory time after self-admin	0.1	0.1	0.2	0.3	-0.1	-0.1	-0.5
Bone: tissue strength	0.3	0.3	1.1	1.1	-0.2	-0.2	-0.1
Total heroin consumption	1.9	2.3	3.6	0.5	-1.9	-1.8	-1.4
Bone: trabecular number	0.0	0.0	0.0	-0.2	0.1	0.0	0.1
Bone: trabecular spacing	1.1	1.4	1.9	-0.3	1.4	1.4	1.3
Bone: trabecular thickness	1.8	2.1	3.0	0.9	-1.7	-1.7	-1.3
Bone: trabecular tissue density	0.4	0.6	0.7	-0.7	0.8	0.8	0.6
Water consumed over 24 hours	0.6	0.7	1.4	0.4	-0.7	-0.7	-1.2
Number of responses in last shaping day	1.0	1.0	3.2	1.8	-0.6	-0.5	-0.6