Hub : Genes

L3mbtl2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	L3mbtl2	0.02	0.01	7.3e-03	0	0.01	0	0.01	8.6e-02	1.2e-02	1.3e-01	5.5e-02
2	BLA	intron excision ratio	chr7_113189083_113190289	0.05	0.04	6.9e-03	-0	0	-0	-0	7.7e-01	1.9e-01	9.6e-01	9.1e-01
3	RMTg	gene expression	L3mbtl2	0.29	0.16	1.0e-02	0.09	0.11	0.01	0.1	2.8e-03	6.3e-04	1.3e-01	1.5e-03
4	Brain	gene expression	L3mbtl2	0.08	0.05	3.2e-03	0.03	0.03	0.04	0.03	4.3e-04	4.0e-04	1.4e-04	5.1e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.2	0.4	0.6	-0.4	0.6	0.7	-0.7
Area under the delay curve	1.2	1.3	2.4	-1.0	0.3	-1.5	1.3
BMI with tail	1.1	3.6	6.0	2.5	-2.3	1.3	-1.2
BMI without tail	0.9	1.8	3.6	0.8	0.0	1.7	-1.9
Body weight	1.1	4.8	8.4	2.9	-2.9	1.4	-0.6
Weight adjusted by age	0.1	0.2	0.5	-0.1	-0.1	-0.3	0.7
Bone surface	0.2	0.3	0.6	-0.8	0.4	-0.3	0.7
Bone volume	0.0	0.0	0.1	-0.2	0.1	0.3	0.0
Breakpoint value in progressive ratio session	0.3	0.4	0.9	-0.0	0.2	0.7	-0.9
Number of licking bursts	1.3	1.5	2.3	-1.4	0.7	-1.5	1.1
Context. condit. distance diff. score	3.3	4.0	9.4	3.1	-2.6	0.1	0.1
Locomotion velocity, session 1	1.3	1.5	3.3	-0.8	-0.1	-1.4	1.8
Locomotion distance, session 1	3.5	4.4	6.7	-2.6	1.6	-2.0	2.1
Locomotion velocity, session 2	0.1	0.1	0.2	0.4	-0.5	0.4	-0.0
Locomotion distance, session 2	1.9	2.6	6.4	-2.5	1.5	-1.0	0.9
Locomotion velocity, session 3	0.3	0.4	0.8	0.2	-0.2	-0.8	0.9
Locomotion distance, session 3	3.2	3.5	5.5	-1.7	1.2	-2.3	2.1
Stereotopy head waving bouts, day 3	0.7	0.9	1.2	1.1	-1.1	0.9	-0.2
Stereotopy head waving duration, day 3	3.2	3.8	5.9	2.4	-2.0	2.0	-1.1
Locomotion velocity, session 7	0.2	0.3	0.4	0.4	-0.4	-0.5	0.7
Locomotion distance, session 7	0.4	0.6	1.1	-0.4	-0.1	-1.1	1.0
Stereotopy head waving bouts, day 7	1.4	1.6	3.5	1.9	-1.5	0.9	-0.1
Stereotopy head waving duration, day 7	1.7	2.0	4.1	2.0	-1.2	1.4	-0.8
Locomotion velocity, session 8	0.9	1.1	2.8	1.2	-1.7	-0.1	0.6
Locomotion distance, session 8	0.3	0.5	1.2	1.1	-0.8	-0.1	0.0
Degree of sensitization distance	3.5	3.5	4.8	2.2	-1.7	1.9	-1.7
Degree of sensitization stereotypy	0.7	0.8	1.8	1.3	-1.1	0.2	0.3
Conditioned locomotion	0.2	0.3	0.7	0.9	-0.7	0.0	-0.0
Cocaine response after cond. corrected	0.0	0.0	0.1	0.3	-0.2	0.3	0.1
Cocaine response after cond. not corrected	0.2	0.2	0.5	0.3	0.0	0.7	-0.5
Cocaine response before conditioning	0.3	0.3	0.7	-0.2	0.6	0.4	-0.8
Saline control response	0.1	0.1	0.2	0.1	0.5	0.0	-0.3
Bone: connectivity density	0.1	0.1	0.2	-0.3	0.3	0.5	-0.2
Bone: cortical apparent density	1.0	1.3	1.8	-1.3	0.8	-1.4	0.9
Bone: cortical area	1.0	1.5	3.0	1.6	-1.7	0.7	-0.2
Bone: cortical porosity	1.7	1.8	3.1	1.3	-0.6	1.8	-1.4
Bone: cortical porosity	2.4	2.6	4.0	1.8	-1.1	2.0	-1.3
Bone: cortical thickness	0.1	0.2	0.7	0.3	-0.9	-0.2	0.1
Bone: cortical thickness	0.3	0.4	0.8	0.1	-0.9	-0.7	0.5
Bone: cortical tissue density	1.0	1.3	2.0	-1.3	0.8	-1.4	1.0
Condit. Reinf. active minus inactive responses	0.2	0.2	0.4	-0.7	0.2	-0.6	0.4
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.3	0.3	-0.5	-0.5	0.4
Condit. Reinf. active responses	0.8	0.9	1.8	-1.3	1.3	-0.3	-0.4
Condit. Reinf. inactive responses	1.7	2.0	4.3	-1.6	2.1	0.0	-0.9
Incentive salience index mean	0.3	0.4	0.9	-1.0	0.5	-0.6	0.2
Condit. Reinf. lever presses	0.3	0.4	1.0	-1.0	0.8	-0.0	-0.3
Condit. Reinf. active minus inactive responses	0.9	1.1	1.8	-0.7	-0.4	-1.3	1.3
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.5	-0.2	-0.6	-0.5	0.7
Condit. Reinf. active responses	0.8	1.1	2.0	-0.0	-1.0	-1.2	1.4
Condit. Reinf. inactive responses	0.9	1.1	1.7	0.4	-1.1	-1.2	1.3
Condit. Reinf. lever presses	0.2	0.2	0.7	-0.8	0.5	-0.2	0.1
Condit. Reinf. lever reinforcers received	0.5	0.6	1.2	-0.2	-0.7	-0.9	1.1
Conditioned reinforcement - actives	2.4	2.4	4.8	-0.3	-0.7	-2.2	2.0
Conditioned reinforcement - inactives	0.4	0.5	1.1	-0.9	0.1	-1.1	0.2
Conditioned locomotion	1.3	1.5	3.8	0.9	-1.9	-0.7	1.0
Patch foraging indifference point 0 sec	0.5	0.7	1.2	-0.6	0.7	1.0	-1.1
Patch foraging indifference point AUC	2.5	2.9	5.4	-1.3	0.1	-2.1	2.3
Delay disc. indifference point, 0s delay	1.6	1.7	2.0	1.4	-0.9	1.4	-1.4
Delay disc. indifference point, 16s delay	2.0	2.0	3.3	-1.8	1.2	-1.4	1.2
Delay disc. indifference point, 2s delay	0.4	0.5	0.9	-0.1	-0.5	-1.0	0.8
Delay disc. indifference point, 24s delay	3.7	3.6	8.1	-1.2	-0.1	-2.2	2.8
Delay disc. indifference point, 4s delay	0.4	0.4	0.8	-0.6	-0.2	-0.9	0.6
Delay disc. indifference point, 8s delay	1.5	1.5	2.3	-1.3	0.8	-1.5	1.2
Indifference point function ln k	1.4	2.0	3.1	1.8	-1.0	1.5	-1.3
Indifference point function log k	1.4	2.0	3.1	1.8	-1.0	1.5	-1.3
Patch foraging total patch changes 0 sec	0.5	0.8	1.1	-0.7	0.8	0.9	-1.1
Patch foraging total patch changes 12 sec	0.1	0.1	0.2	-0.3	-0.1	-0.2	0.4
Patch foraging total patch changes 18 sec	0.1	0.1	0.3	-0.6	0.1	0.1	0.0
Patch foraging total patch changes 24 sec	0.3	0.3	0.6	-0.8	0.5	-0.5	0.5
Patch foraging total patch changes 6 sec	0.2	0.4	1.2	-1.1	0.3	-0.1	0.3
Patch foraging time to switch 0 sec	1.3	2.0	4.1	0.8	0.2	2.0	-1.8
Patch foraging water rate 0 sec	0.1	0.1	0.5	-0.7	0.3	-0.0	0.0
Patch foraging water rate 12 sec	0.2	0.3	0.7	-0.7	0.8	0.1	-0.4
Patch foraging water rate 18 sec	0.7	0.9	2.2	-1.5	1.2	0.2	0.1
Patch foraging water rate 24 sec	0.1	0.2	0.5	0.2	-0.1	0.7	-0.5
Patch foraging water rate 6 sec	0.8	1.2	2.0	-1.4	1.4	-0.8	0.5
Seeking ratio, delayed vs. immediate footshock	1.4	1.6	3.1	-1.7	1.8	0.3	-0.4
Distance traveled before self-admin	0.1	0.1	0.2	-0.1	-0.1	-0.3	-0.4
Distance traveled after self-admin	0.1	0.1	0.2	-0.3	-0.5	0.2	-0.2
Extensor digitorum longus weight	0.3	1.0	1.7	-0.4	1.1	1.1	-1.3
Bone: elastic displacement	0.0	0.0	0.1	0.0	-0.0	-0.1	0.3
Bone: elastic work	2.1	2.7	3.8	2.0	-1.7	1.7	-1.0
Bone: endosteal estimation	0.6	1.3	2.1	1.5	-1.0	1.4	-0.4
Bone: endosteal perimeter	1.3	2.8	5.4	2.3	-1.7	1.6	-0.5
Epididymis fat weight	1.8	4.3	9.6	3.1	-2.7	0.1	0.3
Delta time in closed arm before/after self-admin	1.2	1.2	2.0	0.7	-1.4	-1.1	1.0
Delta time in open arm before/after self-admin	0.4	0.3	0.6	-0.2	0.8	0.5	-0.7
Diff in mean of infusions in LGA sessions	0.4	0.4	1.1	-0.7	0.1	-0.3	1.0
Delay discount exponential model param	1.6	1.7	3.0	1.1	-0.3	1.7	-1.5
Extinction: sum of active levers before priming	0.1	0.1	0.1	-0.2	-0.0	-0.4	0.2
Active lever presses in extinction session 6	0.2	0.2	0.3	0.4	-0.3	0.6	-0.4
Bone: final force	1.0	1.6	4.2	1.4	-2.0	0.6	0.3
Bone: final moment	1.1	1.8	4.5	1.5	-2.1	0.6	0.2
Food consumed during 24 hour testing period	1.1	1.3	2.9	1.4	-1.7	0.6	-0.0
Glucose	0.9	1.3	2.6	-0.2	0.8	1.5	-1.6
Heart weight	2.4	3.4	4.7	2.2	-1.7	1.5	-2.0
Delay discount hyperbolic model param	1.3	1.4	2.7	1.0	-0.1	1.6	-1.3
Intermittent access intake day 1-15 change	0.7	0.7	1.1	-1.0	0.7	-1.0	0.4
Intermittent access intake escalation	0.6	0.5	0.9	-1.0	0.8	-0.8	0.1
Intermittent access intake escalation 2	0.2	0.2	0.4	-0.5	0.6	-0.2	-0.3
Intermitt. access day 1 inactive lever presses	0.5	0.6	0.9	0.5	-0.7	0.8	-1.0
Intermitt. access day 15 inactive lever presses	0.7	0.7	1.7	-0.1	-0.9	-1.3	0.6
Intermitt. access escalation Index	0.0	0.0	0.1	-0.2	-0.1	0.1	-0.3
Intermittent access day 1 total infusions	0.6	0.7	1.6	0.8	-1.3	-0.4	0.5
Intermittent access day 15 total infusions	0.3	0.4	1.0	-0.5	-0.1	-1.0	0.6
Intermittent access terminal intake (last 3 days)	0.3	0.3	0.7	-0.1	-0.3	-0.9	0.6
Intermittent access total infusions	0.2	0.2	0.6	0.4	-0.8	-0.2	0.3
Intermittent access day 1 locomotion	0.3	0.4	0.7	0.7	-0.8	0.4	-0.3
Intermittent access day 15 total locomotion	0.1	0.1	0.3	0.3	-0.5	-0.0	0.3
Intermittent access total locomotion	0.3	0.4	1.0	0.7	-1.0	0.2	0.0
Intermittent access standard deviation	0.5	0.5	0.7	0.8	-0.8	0.4	-0.8
Left kidney weight	6.4	17.9	39.9	5.5	-6.3	0.1	1.0
Right kidney weight	6.9	19.3	44.3	5.6	-6.7	0.1	1.1
Cocaine induced anxiety	1.7	2.0	2.8	1.6	-1.2	1.7	-1.0
Post-drug Anxiety	0.7	0.8	1.5	0.8	-0.7	1.2	-0.7
Baseline Anxiety	1.4	1.4	2.6	-1.6	1.3	-1.0	0.6
Tail length	0.1	0.4	0.8	-0.4	0.9	0.5	-0.6
Length with tail	0.2	0.7	1.4	1.0	-1.2	0.2	0.5
Length without tail	1.0	2.1	4.1	1.2	-2.0	-0.7	1.6
Times rat made contact with spout	0.8	0.9	1.3	0.2	-1.0	-1.1	1.1
Lifetime Intake	0.5	0.6	1.7	0.7	-1.3	-0.2	0.3
Liver weight, left	0.4	0.6	1.7	1.3	-0.9	0.3	-0.1
Liver weight, right	1.3	2.2	5.8	2.4	-1.7	0.3	-0.0
Locomotor activity	1.1	1.7	3.4	1.9	-1.6	0.8	-0.4
Locomotor testing distance	0.0	0.0	0.1	-0.2	0.2	-0.3	0.0
Locomotor testing rearing	0.7	1.2	2.5	1.6	-1.4	0.1	-0.2
Locomotion in novel chamber	1.0	1.2	2.2	-1.2	1.5	-1.1	-0.5
Locomotion in novel chamber post-restriction	0.4	0.5	1.3	-0.9	1.1	-0.2	-0.1
Fecal boli incidents, locomotor time 1	0.2	0.2	0.4	-0.7	0.4	0.2	0.3
Change in fecal boli incidents, locomotor task	2.2	2.1	4.1	-0.1	-0.7	-1.9	2.0
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.8	0.5	-0.5	0.9	-0.2
Bouts of movement, locomotor time 1	0.5	0.5	0.9	0.6	-0.8	-0.3	1.0
Total resting periods, locomotor time 1	0.2	0.2	0.4	0.4	-0.6	-0.1	0.6
Rest time, locomotor task time 1	0.2	0.2	0.6	0.5	-0.8	-0.1	-0.1
Distance moved, locomotor task time 1	0.3	0.3	0.8	0.9	-0.4	0.5	-0.4
Vertical activity count, locomotor time 1	0.2	0.3	0.6	0.2	0.1	0.8	-0.6
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.4	-0.2	0.1	0.6	-0.3
Bouts of movement, locomotor time 2	0.2	0.3	0.6	0.6	-0.7	0.1	-0.2
Total resting periods, locomotor time 2	0.2	0.2	0.5	0.4	-0.7	-0.0	-0.0
Rest time, locomotor task time 2	0.5	0.6	1.0	-0.7	0.1	-1.0	0.9
Distance moved, locomotor task time 2	0.6	0.7	1.4	1.2	-0.7	0.5	-0.8
Vertical activity count, locomotor time 2	0.5	0.5	0.8	0.9	-0.6	0.9	-0.6
Light reinforcement 1	0.0	0.0	0.0	0.1	-0.1	0.1	0.0
Light reinforcement 2	0.6	0.7	1.8	1.3	-0.9	0.5	-0.4
Bone: marrow area	0.7	1.4	2.3	1.5	-1.1	1.4	-0.4
Bone: maximum diameter	2.6	4.7	8.6	2.9	-2.9	1.4	-0.4
Bone: maximum force	1.7	2.9	6.8	2.0	-2.6	0.8	0.1
Bone: maximum moment	1.8	3.1	7.4	2.1	-2.7	0.8	0.1
Mean time between licks in bursts	0.3	0.4	0.9	-0.6	0.9	0.2	-0.7
Mean num. licks in bursts	1.1	1.3	2.6	1.6	-1.6	0.3	0.0
Cd content in liver	0.3	0.4	0.8	0.9	-0.8	-0.1	0.0
Co content in liver	0.2	0.2	0.4	0.5	-0.7	0.2	-0.2
Cu content in liver	2.1	2.5	5.3	-2.1	2.3	0.2	-0.7
Fe content in liver	1.1	1.3	2.9	0.7	0.1	1.7	-1.4
K content in liver	0.4	0.4	1.0	-1.0	0.7	-0.2	-0.0
Mg content in liver	0.6	0.6	1.3	-1.2	0.9	0.2	-0.6
Mn content in liver	0.5	0.6	1.3	-0.0	-0.3	-1.1	1.0
Na content in liver	1.5	1.6	3.4	-1.6	1.8	0.2	-0.6
Rb content in liver	0.1	0.1	0.1	-0.3	-0.1	-0.3	0.3
Se content in liver	0.5	0.7	1.4	-1.0	1.2	-0.5	0.2
Sr content in liver	0.8	0.7	1.0	-0.9	1.0	-0.8	0.4
Zn content in liver	0.7	0.7	1.6	-1.1	1.3	0.0	-0.2
Bone: minimum diameter	0.5	1.0	1.7	1.3	-1.0	1.0	-0.5
Time in familiar zone, hab. session 1	1.2	1.1	2.5	-0.4	-0.5	-1.3	1.6
Time in novel zone, hab. session 1	2.7	2.6	4.3	1.4	-0.3	2.0	-2.1
Total zone transitions, hab. session 1	4.8	6.7	9.5	-3.1	2.3	-2.7	2.2
Total locomotion distance, hab. session 1	2.3	3.3	4.2	-2.0	1.8	-1.9	1.5
Locomotion velocity, hab. session 1	2.4	3.5	5.1	-2.3	1.9	-1.8	1.4
Time in familiar zone, hab. session 2	0.0	0.0	0.1	0.3	0.2	-0.2	-0.1
Time in novel zone, hab. session 2	0.0	0.0	0.1	-0.1	-0.3	0.2	0.1
Total zone transitions, hab. session 2	1.7	2.2	3.8	-2.0	0.8	-1.5	1.4
Total locomotion distance, hab. session 2	0.6	0.8	1.9	-1.4	0.9	-0.4	0.2
Locomotion velocity, hab. session 2	1.0	1.3	3.2	-1.8	1.3	-0.6	0.3
Novel to familiar place preference ratio	1.2	1.2	2.7	1.6	-1.4	0.5	0.0
Novelty place preference	1.6	1.6	3.6	1.9	-1.7	0.3	0.3
Time in novel zone, NPP test	2.0	2.1	4.4	2.1	-1.9	0.3	0.3
Total zone transitions, NPP test	4.5	6.3	9.3	-3.0	2.0	-2.7	2.2
Total locomotion distance, NPP test	1.7	2.3	4.0	-2.0	1.4	-1.4	1.1
Locomotion velocity, NPP test	2.0	2.8	5.2	-2.3	1.8	-1.4	1.0
Intraocular pressure	0.5	0.7	1.4	0.5	-0.7	-0.9	1.2
Delta distance traveled before/after self-admin	0.4	0.4	1.0	-0.0	-0.8	-0.2	1.0
Delta ambulatory time before/after self-admin	0.4	0.5	1.1	-0.1	-0.8	-0.1	1.0
Parametrial fat weight	0.1	0.1	0.2	0.5	-0.5	-0.1	0.0
Pavlov. Cond. lever latency	0.5	0.6	1.2	1.1	-1.1	0.0	0.2
Pavlov. Cond. magazine entry latency	0.4	0.5	1.4	-1.2	0.7	-0.5	0.3
Pavlov. Cond. change in total contacts	0.8	0.8	2.3	-1.5	0.7	-0.7	0.3
Pavlov. Cond. index score	0.2	0.2	0.6	-0.8	0.3	-0.4	0.2
Pavlov. Cond. latency score	0.1	0.2	0.5	-0.7	0.4	-0.1	-0.0
Pavlov. Cond. lever contacts	0.6	0.7	1.3	-1.2	1.1	-0.1	-0.3
Pavlov. Cond. magazine entry number	0.5	0.6	1.1	1.0	-0.5	0.9	-0.7
Pavlov. Cond. intertrial magazine entries	0.6	0.7	1.7	-1.3	1.0	-0.2	0.0
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	1.0	-1.0	0.5	-0.6	0.4
Pavlov. Cond. response bias	0.4	0.4	1.1	-1.1	0.6	-0.4	0.2
Pavlov. Cond. lever latency	1.0	1.3	1.6	1.0	-1.1	-1.2	1.3
Pavlov. Cond. magazine entry latency	1.7	2.0	4.1	-2.0	1.8	0.5	-0.6
Pavlov. Cond. change in total contacts	0.7	0.9	1.9	-0.8	0.3	1.4	-1.0
Pavlov. Cond. index score	1.2	1.6	3.0	-1.7	1.5	0.6	-0.8
Pavlov. Cond. latency score	1.5	1.8	3.8	-1.9	1.7	0.5	-0.7
Pavlov. Cond. lever contacts	1.0	1.3	1.8	-0.9	1.1	1.2	-1.3
Pavlov. Cond. magazine entry number	0.8	1.0	2.3	1.5	-1.2	-0.2	0.3
Pavlov. Cond. intertrial magazine entries	1.3	1.7	3.9	1.6	-2.0	-0.6	0.5
Pavlov. Cond. lever-magazine prob. diff.	1.3	1.7	2.7	-1.6	1.6	0.8	-0.9
Pavlov. Cond. response bias	0.8	1.1	1.2	-1.1	1.0	1.1	-1.1
Time in closed arm before self-admin	5.0	5.7	7.1	-1.6	2.5	2.7	-2.6
Time in closed arm after self-admin	0.7	0.7	1.1	0.9	-0.7	1.0	-0.8
Time in open arm before self-admin	0.5	0.5	1.2	0.1	-0.1	-1.0	1.1
Time in open arm after self-admin	0.2	0.2	0.7	-0.1	0.9	0.2	-0.3
Bone: periosteal estimation	1.2	2.4	3.9	2.0	-1.7	1.5	-0.5
Bone: periosteal perimeter	2.6	4.3	8.2	2.9	-2.5	1.6	-0.6
Bone: post-yield work	0.1	0.2	0.7	0.1	-0.8	0.0	0.2
Progressive ratio test 1 active lever presses	0.5	0.5	1.0	0.4	-1.0	-0.6	0.8
Progressive ratio test 1 breakpoint	0.5	0.5	0.8	0.3	-0.8	-0.7	0.9
Progressive ratio test 1 inactive lever presses	0.5	0.5	1.2	0.6	-0.7	0.3	-1.1
Progressive ratio test 2 active lever presses	1.5	1.6	3.3	-0.7	-0.3	-1.8	1.6
Progressive ratio test 2 breakpoint	1.0	1.1	2.1	-0.5	-0.5	-1.4	1.4
Progressive ratio test 2 inactive lever presses	0.7	0.8	1.8	-1.0	0.4	-1.3	0.4
Incentive Sensitization - Responses	1.1	1.1	2.4	-1.0	0.4	-1.5	0.9
Incentive Sensitization - Breakpoint	1.0	1.0	2.5	-0.9	0.1	-1.6	0.9
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.6	0.2	0.2	0.8	-0.7
Progressive ratio	0.3	0.4	0.7	-0.1	0.4	0.7	-0.8
Food seeking constrained by brief footshock	0.8	1.0	2.4	1.1	-1.6	-0.6	0.5
Seeking ratio, punishment vs. effort	0.6	0.8	1.4	0.6	-1.2	-0.8	0.8
Retroperitoneal fat weight	2.4	7.9	15.9	4.0	-3.9	0.7	0.3
Reaction time number correct	1.0	1.5	1.8	-1.3	1.3	-1.2	1.0
Reaction time mean minus median	0.3	0.4	0.7	0.6	-0.1	0.7	-0.8
Reaction time mean minus median AUC	0.7	0.9	1.9	1.4	-0.7	0.8	-0.9
Reaction time num false alarms	0.2	0.3	0.5	0.2	0.4	0.6	-0.7
Reaction time num false alarms AUC	0.1	0.1	0.4	-0.2	0.6	0.1	-0.3
Reaction time trials correct on left	1.0	1.5	1.8	-1.3	1.3	-1.2	1.0
Reaction time trials on left	1.1	1.6	2.0	-1.4	1.3	-1.2	1.1
Reaction time mean	0.4	0.6	1.4	0.1	0.5	0.9	-1.2
Reaction time mean AUC	0.2	0.3	0.8	0.0	0.4	0.6	-0.9
Median of all reaction times	0.4	0.5	1.1	-0.2	0.7	0.7	-1.0
Reaction time omissions	0.3	0.3	0.6	-0.7	0.8	-0.6	0.2
Reaction time false alarm rate	0.4	0.5	1.0	0.6	-0.1	0.8	-1.0
Reaction time premature initiation rate	0.5	0.7	2.1	-0.3	0.2	1.4	-0.8
Reaction time premature initiations	0.2	0.3	0.5	-0.7	0.5	0.7	-0.1
Std. dev. reaction times	0.4	0.5	0.8	0.9	-0.4	0.6	-0.9
Reaction time trials completed	1.1	1.6	2.0	-1.4	1.3	-1.2	1.1
Reaction time trials AUC	0.8	1.1	1.4	-1.2	1.1	-1.0	0.9
Run reversals in cocaine runway, females	0.5	0.5	0.8	-0.9	0.9	-0.5	0.6
Run reversals in cocaine runway, males	2.0	1.9	4.6	0.2	-0.8	-1.6	2.2
Latency to leave start box in cocaine runway	0.4	0.4	0.8	0.9	-0.4	0.6	-0.5
Latency to leave start box in cocaine runway, F	0.2	0.2	0.4	-0.2	0.6	0.5	-0.4
Latency to leave start box in cocaine runway, M	1.5	1.4	3.1	1.8	-1.5	0.4	-0.4
Std. dev. time between licks in bursts	0.7	0.8	1.8	-1.4	1.1	0.3	-0.4
Total sessions with >9 infusions	1.2	1.3	3.6	1.0	-1.9	-0.4	0.7
Short access day 1 total inactive lever presses	0.5	0.5	1.7	0.5	-1.3	-0.3	0.1
Short access day 10 total inactive lever presses	0.1	0.2	0.4	0.5	-0.6	-0.1	-0.2
Short access day 1 total infusions	0.8	0.9	2.5	0.9	-1.6	-0.5	-0.0
Short access day 10 total infusions	1.0	1.1	1.8	1.2	-1.4	0.9	-0.3
Short access total infusions	1.5	1.7	4.6	1.5	-2.1	0.2	-0.1
Short access day 1 locomotion	0.3	0.3	0.5	0.4	-0.6	0.3	-0.7
Short access day 10 total locomotion	1.0	1.2	3.2	0.5	0.1	1.1	-1.8
Short access total locomotion	1.2	1.3	2.2	1.3	-1.5	0.7	-0.8
One hour access (0.3 mA shock)	0.5	0.6	1.1	-0.8	0.5	-1.0	0.5
Compulsive drug intake	3.6	3.6	5.0	-2.2	1.4	-1.9	1.9
One hour access (shock baseline)	0.3	0.4	0.6	0.7	-0.3	0.5	-0.8
Social response proportion	2.7	2.9	5.4	1.0	-0.2	2.3	-2.3
Social responses	0.1	0.1	0.2	-0.4	0.3	-0.1	0.3
Social time	1.0	1.3	2.8	-1.7	1.5	-0.4	-0.2
Soleus weight	0.6	1.6	2.5	-1.4	0.4	-1.6	1.4
Bone: stiffness	1.4	2.2	3.9	1.8	-2.0	1.3	-0.6
Tibialis anterior weight	0.3	1.0	2.1	-1.5	1.4	-0.0	-0.4
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.4	-0.2	-0.0	-0.1	0.7
Time to tail flick, vehicle, after self-admin	0.5	0.6	1.7	-0.7	1.3	0.2	0.1
Time to tail flick, test, before self-admin	0.4	0.4	0.9	0.0	-0.0	-0.8	1.0
Time to tail flick, test, after self-admin	0.6	0.7	1.4	-1.1	1.2	-0.0	-0.2
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	0.8	0.0	0.5	0.7	-0.9
Delta time to tail flick, test, before/after SA	1.6	1.5	2.8	-1.6	1.7	0.2	-0.7
Tibia length	0.5	1.5	3.2	0.9	-1.8	-0.5	1.2
Ambulatory time before self-admin	0.4	0.4	1.4	-0.5	0.2	-1.2	-0.0
Ambulatory time after self-admin	0.6	0.6	1.8	-1.3	0.4	-0.6	0.4
Bone: tissue strength	0.1	0.1	0.2	0.3	-0.4	0.2	0.1
Total heroin consumption	0.1	0.2	0.4	-0.1	-0.4	-0.2	0.7
Bone: trabecular number	0.0	0.0	0.1	0.3	0.0	0.0	0.0
Bone: trabecular spacing	0.7	0.9	2.4	0.8	-1.6	-0.2	0.6
Bone: trabecular thickness	0.6	0.7	1.6	0.1	0.7	1.0	-1.3
Bone: trabecular tissue density	1.3	1.9	2.3	-1.1	1.5	1.4	-1.5
Water consumed over 24 hours	0.5	0.6	1.0	0.3	-1.0	-0.6	0.9
Number of responses in last shaping day	0.6	0.7	1.1	-0.8	0.6	0.7	-1.0