Hub : Genes

Krt4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Eye	gene expression	Krt4	0.49	0.31	2.5e-03	0.09	0.09	0.1	0.12	1.7e-02	1.7e-02	1.5e-02	6.5e-03
2	Eye	isoform ratio	NM_001008806.2	0.5	0.18	5.1e-05	0.08	0.08	0.08	0.1	2.7e-02	2.1e-02	2.7e-02	1.2e-02
3	Liver	gene expression	Krt4	0.08	0.05	5.2e-07	0.06	0.06	0.08	0.06	1.2e-07	6.3e-07	5.1e-09	4.1e-07
4	Eye	isoform ratio	XM_006242395.5	0.48	0.2	2.1e-04	0.09	0.07	0.08	0.08	2.1e-02	3.1e-02	2.6e-02	2.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.8	1.3	3.3	-1.8	1.1	-0.7	-0.4
Area under the delay curve	0.3	0.3	0.7	-0.8	0.7	0.1	-0.3
BMI with tail	2.0	6.8	11.7	-3.4	3.0	0.1	-2.4
BMI without tail	0.8	2.5	4.3	-1.6	2.1	0.8	-1.5
Body weight	0.5	2.2	3.2	-1.8	1.8	-0.3	-1.5
Weight adjusted by age	0.4	0.6	1.5	0.9	-0.2	-0.3	-1.2
Bone surface	1.5	2.6	6.6	-2.6	1.9	-0.0	-0.6
Bone volume	1.5	2.7	6.4	-2.5	1.9	0.0	-0.8
Breakpoint value in progressive ratio session	1.1	1.3	3.5	-1.9	1.1	0.6	0.0
Number of licking bursts	0.5	0.8	3.0	0.6	0.2	1.7	0.0
Context. condit. distance diff. score	0.2	0.2	0.5	-0.7	0.2	0.4	0.3
Locomotion velocity, session 1	5.8	6.2	11.4	3.4	-2.8	-0.6	2.3
Locomotion distance, session 1	2.4	3.1	8.2	2.9	-1.8	0.3	0.9
Locomotion velocity, session 2	3.2	3.7	6.1	2.5	-2.0	-1.2	1.8
Locomotion distance, session 2	2.0	2.8	6.6	2.6	-1.8	-0.1	1.1
Locomotion velocity, session 3	4.2	4.8	6.9	2.4	-2.4	-1.1	2.6
Locomotion distance, session 3	3.6	3.9	6.2	2.0	-2.1	-1.0	2.5
Stereotopy head waving bouts, day 3	1.8	2.1	2.9	-1.5	1.7	1.1	-1.4
Stereotopy head waving duration, day 3	0.2	0.2	0.3	-0.6	0.6	0.3	-0.2
Locomotion velocity, session 7	0.7	0.8	1.3	0.8	-1.0	0.4	1.1
Locomotion distance, session 7	2.9	3.7	6.4	2.5	-2.0	-0.2	2.1
Stereotopy head waving bouts, day 7	3.2	3.6	4.4	-1.8	2.0	1.7	-2.1
Stereotopy head waving duration, day 7	2.2	2.7	3.2	-1.8	1.8	1.4	-1.5
Locomotion velocity, session 8	0.1	0.2	0.4	0.2	-0.2	0.5	0.6
Locomotion distance, session 8	1.8	2.7	4.3	2.1	-1.9	-0.2	1.7
Degree of sensitization distance	0.3	0.3	0.6	-0.0	0.5	0.7	-0.8
Degree of sensitization stereotypy	2.0	2.2	2.5	-1.4	1.5	1.4	-1.6
Conditioned locomotion	0.4	0.5	0.8	0.9	-0.9	-0.4	0.4
Cocaine response after cond. corrected	0.5	0.6	1.8	1.4	-0.5	0.4	-0.5
Cocaine response after cond. not corrected	0.4	0.5	1.2	1.1	-0.8	-0.2	-0.1
Cocaine response before conditioning	0.8	0.9	1.7	-0.1	-0.9	-1.0	1.3
Saline control response	0.0	0.1	0.2	-0.1	-0.4	-0.2	0.0
Bone: connectivity density	0.3	0.5	1.2	-0.8	-0.1	-1.1	0.3
Bone: cortical apparent density	1.1	1.5	3.4	1.0	0.3	1.3	-1.8
Bone: cortical area	1.0	1.6	3.6	-1.9	1.4	-0.3	-0.9
Bone: cortical porosity	1.1	1.2	1.7	0.5	-1.1	-1.3	1.3
Bone: cortical porosity	1.3	1.4	2.1	0.5	-1.3	-1.5	1.3
Bone: cortical thickness	0.2	0.3	0.5	-0.6	0.6	-0.2	-0.7
Bone: cortical thickness	1.7	2.0	3.2	1.3	-1.5	-1.8	0.8
Bone: cortical tissue density	1.1	1.5	3.1	1.1	0.2	1.2	-1.8
Condit. Reinf. active minus inactive responses	0.5	0.5	1.0	0.8	-1.0	-0.5	0.5
Condit. Reinf. active-inactive response ratio	0.5	0.5	0.9	0.6	-1.0	-0.8	0.6
Condit. Reinf. active responses	1.2	1.4	2.3	1.5	-1.5	-0.8	0.8
Condit. Reinf. inactive responses	1.2	1.4	2.9	1.7	-1.4	-0.6	0.7
Incentive salience index mean	0.1	0.1	0.3	0.4	-0.5	-0.1	0.1
Condit. Reinf. lever presses	0.4	0.5	1.1	-0.2	0.6	1.1	-0.8
Condit. Reinf. active minus inactive responses	0.7	1.0	1.4	-0.9	1.0	0.8	-1.2
Condit. Reinf. active-inactive response ratio	0.3	0.4	0.5	-0.7	0.6	0.3	-0.6
Condit. Reinf. active responses	0.9	1.3	1.7	-0.9	1.1	1.3	-1.2
Condit. Reinf. inactive responses	0.1	0.2	0.5	0.2	0.1	0.7	-0.3
Condit. Reinf. lever presses	0.3	0.4	0.8	0.3	-0.9	-0.6	0.7
Condit. Reinf. lever reinforcers received	0.3	0.4	0.7	-0.4	0.5	0.8	-0.6
Conditioned reinforcement - actives	0.5	0.9	2.9	0.7	-0.1	1.7	0.3
Conditioned reinforcement - inactives	0.4	0.6	1.3	0.9	-1.1	-0.2	0.4
Conditioned locomotion	0.4	0.5	1.7	0.1	0.1	1.3	0.6
Patch foraging indifference point 0 sec	0.7	1.4	3.2	1.8	-1.1	0.8	0.6
Patch foraging indifference point AUC	0.6	0.9	1.4	1.2	-0.2	1.1	-1.0
Delay disc. indifference point, 0s delay	0.0	0.0	0.1	0.2	0.1	-0.3	-0.2
Delay disc. indifference point, 16s delay	0.2	0.3	0.7	-0.8	0.4	-0.3	-0.4
Delay disc. indifference point, 2s delay	5.0	5.5	7.3	-1.8	2.7	2.3	-2.5
Delay disc. indifference point, 24s delay	0.1	0.2	0.3	-0.5	0.4	0.4	-0.2
Delay disc. indifference point, 4s delay	0.6	0.6	1.2	-1.1	0.9	0.3	-0.4
Delay disc. indifference point, 8s delay	0.1	0.2	0.4	-0.4	0.1	-0.4	0.6
Indifference point function ln k	0.7	1.2	3.2	-1.8	1.0	-0.8	0.4
Indifference point function log k	0.7	1.2	3.2	-1.8	1.0	-0.8	0.4
Patch foraging total patch changes 0 sec	1.0	2.0	4.3	2.1	-1.5	0.5	1.1
Patch foraging total patch changes 12 sec	1.1	1.5	3.9	2.0	-1.1	0.8	-0.2
Patch foraging total patch changes 18 sec	1.5	2.4	5.5	2.3	-1.4	1.3	0.5
Patch foraging total patch changes 24 sec	0.6	1.0	2.7	1.1	-0.3	1.6	-0.1
Patch foraging total patch changes 6 sec	1.7	2.6	6.2	2.5	-0.5	2.0	-0.2
Patch foraging time to switch 0 sec	0.1	0.2	0.3	0.2	0.3	0.5	-0.6
Patch foraging water rate 0 sec	0.0	0.1	0.2	-0.4	0.1	-0.2	0.1
Patch foraging water rate 12 sec	0.4	0.9	2.2	-0.0	-0.8	-0.9	1.5
Patch foraging water rate 18 sec	0.0	0.0	0.0	-0.1	-0.1	0.0	0.2
Patch foraging water rate 24 sec	0.4	0.5	0.8	-0.9	0.9	0.6	-0.3
Patch foraging water rate 6 sec	0.9	1.3	2.6	-1.6	-0.1	-1.3	0.8
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.0	-0.0	-0.1	-0.0	0.1
Distance traveled before self-admin	0.0	0.0	0.1	-0.3	0.1	-0.1	-0.0
Distance traveled after self-admin	1.1	1.3	2.5	-0.7	-0.9	-1.2	1.6
Extensor digitorum longus weight	7.0	27.5	42.4	-4.7	6.5	3.8	-5.6
Bone: elastic displacement	2.8	3.2	5.7	1.9	-1.9	-0.4	2.4
Bone: elastic work	1.6	2.0	3.4	1.4	-1.3	-1.0	1.8
Bone: endosteal estimation	1.3	2.8	7.2	-2.7	1.9	0.0	-0.4
Bone: endosteal perimeter	1.5	3.3	7.7	-2.8	2.1	-0.0	-1.0
Epididymis fat weight	2.4	8.3	15.6	1.0	-2.8	-3.9	3.0
Delta time in closed arm before/after self-admin	0.5	0.5	1.7	-1.3	0.4	0.1	-0.1
Delta time in open arm before/after self-admin	4.7	4.6	5.9	2.0	-2.4	-2.1	2.1
Diff in mean of infusions in LGA sessions	0.3	0.4	1.1	-0.2	0.5	-0.3	-1.0
Delay discount exponential model param	0.5	0.6	1.1	1.1	-0.9	-0.2	0.4
Extinction: sum of active levers before priming	2.0	2.2	4.2	-1.7	2.1	0.8	-1.1
Active lever presses in extinction session 6	0.4	0.4	0.8	-0.9	0.7	0.7	0.1
Bone: final force	1.2	2.0	4.5	-2.1	1.7	-0.5	-0.6
Bone: final moment	1.4	2.3	5.4	-2.3	1.8	-0.5	-0.5
Food consumed during 24 hour testing period	0.5	0.6	1.1	-0.4	-0.5	-1.0	1.0
Glucose	0.4	0.6	1.4	1.2	-0.6	0.4	0.8
Heart weight	0.7	1.1	2.8	-1.1	-0.3	-1.7	0.5
Delay discount hyperbolic model param	0.7	0.8	1.3	1.1	-1.1	-0.4	0.6
Intermittent access intake day 1-15 change	0.1	0.2	0.7	-0.1	-0.3	0.2	0.8
Intermittent access intake escalation	0.0	0.0	0.1	-0.0	-0.1	0.1	0.4
Intermittent access intake escalation 2	0.2	0.2	0.4	0.1	-0.4	-0.6	0.6
Intermitt. access day 1 inactive lever presses	0.2	0.7	1.2	-1.1	0.5	0.3	-1.1
Intermitt. access day 15 inactive lever presses	0.1	0.2	0.4	-0.3	-0.4	-0.6	0.3
Intermitt. access escalation Index	2.0	2.8	5.7	-0.5	1.7	2.4	-1.5
Intermittent access day 1 total infusions	0.3	0.4	1.3	0.5	-0.5	1.1	0.1
Intermittent access day 15 total infusions	0.8	1.1	3.4	1.0	-0.4	1.8	0.2
Intermittent access terminal intake (last 3 days)	0.9	1.2	4.5	0.5	-0.1	2.1	0.1
Intermittent access total infusions	1.2	1.4	5.5	0.3	0.1	2.4	-0.1
Intermittent access day 1 locomotion	0.7	0.8	3.3	0.2	-0.1	1.8	0.2
Intermittent access day 15 total locomotion	0.4	0.7	2.1	-0.2	-0.7	-0.4	1.5
Intermittent access total locomotion	0.3	0.4	1.0	-0.2	-0.3	1.0	0.7
Intermittent access standard deviation	0.3	0.7	1.3	0.8	-1.1	-0.4	0.9
Left kidney weight	0.1	0.5	1.3	0.0	0.2	-1.2	-0.9
Right kidney weight	0.2	1.1	1.5	-0.7	0.9	-1.2	-1.2
Cocaine induced anxiety	0.4	0.5	0.6	-0.8	0.8	0.8	0.6
Post-drug Anxiety	0.7	0.7	1.9	-1.4	0.3	-0.2	0.9
Baseline Anxiety	0.8	0.9	3.1	-0.1	-0.7	-1.8	-0.1
Tail length	0.3	1.1	2.7	1.6	-1.0	0.2	0.8
Length with tail	0.1	0.4	0.6	0.7	-0.6	-0.7	0.3
Length without tail	0.2	0.5	1.0	-0.9	0.4	-1.0	-0.2
Times rat made contact with spout	0.5	0.5	1.1	-0.4	-0.4	-0.8	1.1
Lifetime Intake	0.8	1.0	3.9	0.1	-0.0	2.0	0.1
Liver weight, left	2.0	3.2	8.7	-2.9	2.0	-0.5	-0.3
Liver weight, right	0.4	0.7	2.2	-0.8	0.3	-1.5	-0.2
Locomotor activity	0.1	0.1	0.2	0.5	-0.2	-0.0	0.3
Locomotor testing distance	0.3	0.5	0.9	0.9	-0.5	0.5	0.9
Locomotor testing rearing	0.1	0.3	0.6	0.7	-0.3	-0.1	0.7
Locomotion in novel chamber	2.9	3.7	6.6	-2.3	2.6	1.0	-1.4
Locomotion in novel chamber post-restriction	0.7	1.2	3.2	-0.7	1.0	1.8	-0.4
Fecal boli incidents, locomotor time 1	1.8	2.6	3.6	1.7	-1.9	-0.9	1.7
Change in fecal boli incidents, locomotor task	0.5	0.5	0.8	-0.7	0.9	0.7	-0.5
Time >=10cm from walls, locomotor time 1	0.6	0.7	1.6	0.3	-0.9	-0.4	1.3
Bouts of movement, locomotor time 1	0.6	0.7	1.4	1.2	-1.1	-0.3	0.5
Total resting periods, locomotor time 1	1.5	1.7	3.0	1.7	-1.6	-0.6	0.9
Rest time, locomotor task time 1	0.7	0.8	1.6	1.3	-0.7	0.8	0.8
Distance moved, locomotor task time 1	0.4	0.6	0.9	-0.8	0.9	0.5	-0.9
Vertical activity count, locomotor time 1	0.8	1.8	3.2	-1.3	1.4	0.7	-1.8
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.5	0.3	-0.3	0.1	0.7
Bouts of movement, locomotor time 2	1.2	1.9	3.0	-1.4	1.7	1.1	-1.3
Total resting periods, locomotor time 2	1.3	2.3	3.4	-1.4	1.8	1.2	-1.6
Rest time, locomotor task time 2	0.3	0.4	0.8	0.9	-0.6	0.6	0.2
Distance moved, locomotor task time 2	0.1	0.1	0.4	0.1	-0.0	-0.7	-0.2
Vertical activity count, locomotor time 2	0.3	0.4	0.7	-0.4	0.8	0.4	-0.8
Light reinforcement 1	0.4	0.9	2.2	1.5	-0.7	1.0	-0.1
Light reinforcement 2	0.7	1.2	3.2	1.8	-1.2	0.1	0.1
Bone: marrow area	1.2	2.7	7.0	-2.6	1.9	0.0	-0.4
Bone: maximum diameter	0.8	1.5	3.4	-1.8	1.4	0.5	-0.7
Bone: maximum force	1.4	2.5	4.6	-2.0	2.1	0.5	-1.1
Bone: maximum moment	1.5	2.7	5.1	-2.1	2.3	0.5	-1.0
Mean time between licks in bursts	0.5	1.3	2.4	1.6	-0.9	0.7	1.2
Mean num. licks in bursts	1.2	1.8	5.5	-0.6	-0.7	-2.3	0.9
Cd content in liver	0.3	0.3	0.6	0.5	-0.5	0.3	0.8
Co content in liver	0.5	0.5	1.1	-0.4	0.9	1.1	-0.3
Cu content in liver	3.2	3.8	11.4	-3.4	1.9	0.4	-0.1
Fe content in liver	0.3	0.3	1.1	0.1	0.4	1.0	0.4
K content in liver	0.3	0.3	0.6	-0.6	0.8	0.5	-0.1
Mg content in liver	0.3	0.3	0.4	-0.5	0.4	0.5	0.7
Mn content in liver	0.2	0.2	0.4	0.7	0.0	0.5	-0.2
Na content in liver	0.6	0.6	1.4	-1.2	1.0	0.5	0.2
Rb content in liver	1.0	1.1	1.6	-1.3	1.0	1.3	0.6
Se content in liver	0.4	0.5	0.6	0.8	-0.7	-0.2	0.8
Sr content in liver	0.4	0.3	0.7	0.4	-0.6	-0.8	0.4
Zn content in liver	0.8	0.9	1.4	0.4	-1.2	-0.9	1.2
Bone: minimum diameter	1.4	2.6	6.2	-2.5	1.8	-0.3	-1.1
Time in familiar zone, hab. session 1	0.7	0.7	1.6	0.4	-0.7	-1.3	0.6
Time in novel zone, hab. session 1	1.7	1.7	3.1	-0.8	1.2	1.7	-1.4
Total zone transitions, hab. session 1	0.4	0.6	0.8	0.8	-0.1	0.9	-0.9
Total locomotion distance, hab. session 1	1.2	1.6	2.8	1.7	-1.6	-0.9	0.5
Locomotion velocity, hab. session 1	1.1	1.5	2.7	1.7	-1.5	-0.8	0.6
Time in familiar zone, hab. session 2	0.3	0.3	0.6	-0.8	0.6	-0.2	0.5
Time in novel zone, hab. session 2	0.5	0.5	0.9	0.2	0.3	1.0	-0.9
Total zone transitions, hab. session 2	0.6	0.7	1.7	1.3	-0.9	-0.1	0.5
Total locomotion distance, hab. session 2	1.3	1.8	2.4	1.6	-1.6	-1.4	0.5
Locomotion velocity, hab. session 2	1.6	2.1	2.8	1.6	-1.7	-1.6	0.7
Novel to familiar place preference ratio	0.5	0.5	1.3	-0.6	0.5	-0.3	-1.2
Novelty place preference	0.3	0.3	0.9	-0.4	0.4	-0.1	-0.9
Time in novel zone, NPP test	0.4	0.4	1.1	-0.6	0.5	-0.0	-1.1
Total zone transitions, NPP test	2.1	3.0	7.2	2.7	-2.1	-0.1	0.8
Total locomotion distance, NPP test	4.0	5.5	9.3	3.0	-2.8	-1.8	1.3
Locomotion velocity, NPP test	4.4	6.2	9.7	3.1	-3.0	-2.0	1.4
Intraocular pressure	0.7	0.9	1.8	0.5	-0.6	1.2	1.3
Delta distance traveled before/after self-admin	3.9	4.1	6.1	0.0	-2.1	-2.5	2.5
Delta ambulatory time before/after self-admin	3.2	4.0	7.6	-0.5	-1.8	-2.8	2.2
Parametrial fat weight	0.6	1.5	3.1	0.7	-1.5	-0.3	1.8
Pavlov. Cond. lever latency	1.9	2.4	4.8	1.0	-1.5	-2.2	1.1
Pavlov. Cond. magazine entry latency	2.8	3.5	5.5	-1.2	2.1	2.3	-1.7
Pavlov. Cond. change in total contacts	3.5	3.7	4.6	-1.8	2.1	1.9	-1.8
Pavlov. Cond. index score	4.7	5.9	8.4	-1.8	2.7	2.9	-2.1
Pavlov. Cond. latency score	4.6	5.9	8.6	-1.9	2.7	2.9	-2.0
Pavlov. Cond. lever contacts	2.2	2.7	5.4	-1.0	1.7	2.3	-1.2
Pavlov. Cond. magazine entry number	2.1	2.6	4.6	1.0	-1.7	-2.1	1.4
Pavlov. Cond. intertrial magazine entries	2.5	3.0	5.0	1.8	-2.2	-1.3	1.4
Pavlov. Cond. lever-magazine prob. diff.	4.7	5.9	8.9	-1.8	2.7	3.0	-2.0
Pavlov. Cond. response bias	1.5	1.9	4.0	-0.7	1.4	2.0	-1.0
Pavlov. Cond. lever latency	1.5	2.1	3.4	-1.2	1.8	1.0	-1.6
Pavlov. Cond. magazine entry latency	3.5	4.3	5.8	2.2	-2.4	-1.8	1.8
Pavlov. Cond. change in total contacts	0.2	0.3	0.8	-0.6	0.4	0.3	-0.9
Pavlov. Cond. index score	2.2	3.0	4.6	1.7	-2.2	-1.4	1.5
Pavlov. Cond. latency score	2.2	2.9	4.6	1.8	-2.1	-1.4	1.4
Pavlov. Cond. lever contacts	2.2	3.1	4.9	1.4	-2.2	-1.4	1.8
Pavlov. Cond. magazine entry number	1.3	1.6	2.4	-1.2	1.5	1.3	-1.0
Pavlov. Cond. intertrial magazine entries	0.3	0.5	1.3	0.3	-0.6	-0.4	1.1
Pavlov. Cond. lever-magazine prob. diff.	1.7	2.3	3.6	1.5	-1.9	-1.4	1.3
Pavlov. Cond. response bias	1.8	2.5	3.8	1.2	-1.9	-1.3	1.7
Time in closed arm before self-admin	0.8	1.0	2.5	0.2	0.8	0.8	-1.6
Time in closed arm after self-admin	2.9	3.1	4.0	-1.2	1.8	2.0	-2.0
Time in open arm before self-admin	1.9	2.1	3.1	-1.4	1.6	1.8	-0.9
Time in open arm after self-admin	1.1	1.2	1.6	0.6	-1.2	-1.3	1.2
Bone: periosteal estimation	1.9	4.0	10.1	-3.2	2.3	-0.1	-0.8
Bone: periosteal perimeter	2.3	4.0	7.9	-2.8	2.4	0.3	-1.5
Bone: post-yield work	0.8	1.2	2.1	-1.4	1.5	0.5	-0.6
Progressive ratio test 1 active lever presses	1.6	2.0	4.1	1.5	-0.9	2.0	0.7
Progressive ratio test 1 breakpoint	1.6	2.0	3.7	1.5	-1.0	1.9	0.9
Progressive ratio test 1 inactive lever presses	0.4	0.5	1.2	0.0	0.1	1.1	-0.9
Progressive ratio test 2 active lever presses	0.7	0.8	2.4	-0.7	0.5	1.6	-0.1
Progressive ratio test 2 breakpoint	0.9	1.0	2.8	-0.8	0.7	1.7	-0.3
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.5	-0.7	-0.0	0.6	0.4
Incentive Sensitization - Responses	0.9	1.2	2.7	-1.6	1.2	0.6	-0.6
Incentive Sensitization - Breakpoint	1.2	1.5	3.0	-1.7	1.4	0.7	-0.8
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.4	-0.1	0.3	0.4	-0.6
Progressive ratio	0.1	0.1	0.5	0.2	0.1	0.7	-0.0
Food seeking constrained by brief footshock	0.1	0.2	0.4	-0.5	-0.1	0.6	-0.1
Seeking ratio, punishment vs. effort	0.1	0.1	0.2	-0.5	-0.3	-0.4	-0.1
Retroperitoneal fat weight	2.0	8.7	12.4	2.5	-3.5	-2.1	3.4
Reaction time number correct	0.3	0.6	2.3	0.4	-0.4	-0.1	1.5
Reaction time mean minus median	0.1	0.2	0.4	0.5	-0.2	-0.0	-0.7
Reaction time mean minus median AUC	0.1	0.3	0.8	0.3	0.1	0.7	-0.9
Reaction time num false alarms	1.4	1.9	3.6	1.8	-1.9	-0.6	0.6
Reaction time num false alarms AUC	1.1	1.7	3.5	1.9	-1.8	-0.4	0.3
Reaction time trials correct on left	0.3	0.6	2.3	0.4	-0.4	-0.1	1.5
Reaction time trials on left	0.4	0.7	2.3	0.4	-0.5	-0.2	1.5
Reaction time mean	0.4	0.6	1.0	-1.0	0.2	-0.9	-0.8
Reaction time mean AUC	0.4	0.7	1.1	-1.1	0.4	-0.9	-0.8
Median of all reaction times	0.7	0.9	1.8	-1.4	0.3	-1.3	-0.5
Reaction time omissions	2.0	2.9	7.9	0.8	-1.8	-2.8	0.1
Reaction time false alarm rate	0.5	0.7	1.1	1.1	-1.0	-0.1	-0.7
Reaction time premature initiation rate	0.7	0.9	1.5	0.0	-1.2	-1.1	1.1
Reaction time premature initiations	0.9	1.5	3.1	0.2	-1.3	-1.2	1.8
Std. dev. reaction times	0.1	0.2	0.8	-0.0	-0.1	-0.4	-0.9
Reaction time trials completed	0.4	0.7	2.3	0.4	-0.5	-0.2	1.5
Reaction time trials AUC	0.3	0.5	1.8	0.3	-0.3	-0.1	1.4
Run reversals in cocaine runway, females	0.5	0.5	1.8	-0.3	-0.2	-1.3	-0.1
Run reversals in cocaine runway, males	1.2	1.2	2.6	0.9	0.6	1.0	-1.6
Latency to leave start box in cocaine runway	0.2	0.2	0.4	-0.6	0.4	0.4	-0.2
Latency to leave start box in cocaine runway, F	0.2	0.2	0.7	0.1	0.1	0.8	-0.3
Latency to leave start box in cocaine runway, M	0.7	0.6	1.9	-1.4	0.7	-0.4	-0.1
Std. dev. time between licks in bursts	1.0	1.4	2.8	1.7	-1.1	0.2	1.3
Total sessions with >9 infusions	0.5	0.5	1.8	-0.3	0.2	1.3	-0.5
Short access day 1 total inactive lever presses	0.1	0.1	0.4	-0.0	-0.1	0.6	0.1
Short access day 10 total inactive lever presses	0.3	0.6	1.7	-1.3	0.2	-0.9	-0.3
Short access day 1 total infusions	0.1	0.1	0.4	-0.6	-0.2	-0.2	0.2
Short access day 10 total infusions	0.5	0.7	2.6	0.2	-0.1	1.6	-0.2
Short access total infusions	0.3	0.4	1.4	-0.1	-0.1	1.2	0.3
Short access day 1 locomotion	0.1	0.1	0.2	-0.5	0.2	0.3	-0.4
Short access day 10 total locomotion	0.1	0.2	0.3	-0.6	0.2	0.3	-0.5
Short access total locomotion	0.3	0.4	1.2	-0.1	0.2	1.1	-0.5
One hour access (0.3 mA shock)	2.3	2.7	3.3	-1.8	1.8	1.8	-1.0
Compulsive drug intake	1.4	1.7	3.7	-1.9	1.4	0.7	-0.9
One hour access (shock baseline)	0.5	0.8	1.8	-0.7	0.9	1.3	-0.4
Social response proportion	1.7	1.9	2.8	0.9	-1.7	-1.6	1.3
Social responses	0.9	1.2	2.3	1.5	-1.2	-0.9	0.4
Social time	1.7	2.3	4.4	1.1	-1.6	-2.1	1.1
Soleus weight	0.1	0.3	0.6	-0.8	0.6	-0.3	0.2
Bone: stiffness	3.1	5.1	8.1	-2.8	2.8	0.6	-2.0
Tibialis anterior weight	8.2	27.7	39.0	-4.1	6.1	4.2	-6.2
Time to tail flick, vehicle, before self-admin	0.4	0.4	0.9	-0.4	0.7	0.2	-0.9
Time to tail flick, vehicle, after self-admin	0.3	0.4	0.9	-0.6	0.4	-0.9	-0.5
Time to tail flick, test, before self-admin	0.5	0.5	1.2	1.1	-0.6	-0.3	-0.8
Time to tail flick, test, after self-admin	1.2	1.2	1.8	-1.2	0.8	-1.3	-1.0
Delta time to tail flick, vehicle, before/after SA	0.3	0.2	0.4	-0.3	-0.1	-0.7	0.6
Delta time to tail flick, test, before/after SA	1.2	1.2	2.5	-1.6	0.7	-1.4	-0.2
Tibia length	0.4	1.2	3.4	-1.8	0.6	-1.0	0.0
Ambulatory time before self-admin	0.0	0.1	0.1	0.1	-0.1	0.3	0.3
Ambulatory time after self-admin	1.6	1.8	2.9	-1.0	-0.9	-1.6	1.7
Bone: tissue strength	2.0	2.0	3.0	-1.1	1.7	1.6	-1.2
Total heroin consumption	1.2	1.4	4.1	-2.0	1.3	0.2	-0.0
Bone: trabecular number	0.3	0.6	1.5	-0.8	0.0	-1.2	0.4
Bone: trabecular spacing	0.6	0.8	2.1	-0.5	0.6	1.5	-0.6
Bone: trabecular thickness	0.1	0.1	0.2	0.1	0.1	-0.3	-0.5
Bone: trabecular tissue density	1.0	1.5	3.0	-0.1	0.9	1.5	-1.7
Water consumed over 24 hours	0.2	0.3	1.2	0.1	-0.3	0.1	1.1
Number of responses in last shaping day	2.2	2.4	3.5	1.9	-1.7	-1.8	0.2