Hub : Genes

Krt222

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Krt222 0.03 0.02 3.0e-04 0.03 0.03 0.03 0.03 3.0e-04 9.7e-05 8.6e-04 7.7e-04
2 pVTA mRNA stability Krt222 0.04 0.04 3.5e-03 0.03 0.03 0.02 0.03 3.4e-03 2.8e-03 1.8e-02 3.2e-03
3 Adipose isoform ratio XM_006247443.5 0.08 0.06 2.7e-06 0.04 0.05 0.06 0.01 1.3e-05 3.4e-06 7.1e-07 1.2e-02
4 PL mRNA stability Krt222 0.05 0.03 1.1e-04 0.04 0.03 0.03 0.04 3.8e-05 2.2e-04 2.4e-04 2.6e-05
5 OFC mRNA stability Krt222 0.26 0.15 1.6e-03 0.09 0.07 0.07 -0.01 3.5e-03 1.2e-02 9.5e-03 6.8e-01
6 LHb mRNA stability Krt222 0.3 0.15 6.4e-05 0.23 0.22 0.19 0.03 2.7e-06 6.1e-06 2.5e-05 8.2e-02
7 NAcc gene expression Krt222 0.17 0.07 0.0e+00 0.17 0.16 0.17 0.17 2.2e-24 2.7e-23 9.2e-26 3.5e-25
8 Brain mRNA stability Krt222 0.04 0.02 6.3e-04 0.04 0.02 0.01 0.02 1.5e-04 5.2e-03 1.7e-02 2.7e-03
9 Adipose gene expression Krt222 0.22 0.1 0.0e+00 0.15 0.2 0.2 0.22 1.4e-16 1.7e-21 2.9e-21 1.7e-23
10 Brain gene expression Krt222 0.1 0.06 2.5e-04 0.02 0.05 0.04 0.04 8.6e-03 2.5e-05 1.2e-04 1.0e-04
11 IC gene expression Krt222 0.19 0.12 9.0e-04 0 0.05 0.09 0.03 2.9e-01 4.4e-03 1.3e-04 2.0e-02
12 PL gene expression Krt222 0.21 0.08 8.8e-09 0.04 0.07 0.06 0.06 2.1e-05 1.6e-08 2.5e-07 3.5e-07
13 BLA gene expression Krt222 0.16 0.08 5.7e-04 0.06 0.05 0.07 0.05 3.2e-04 8.2e-04 2.2e-04 1.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density1.22.35.31.01.70.31.8-2.3-2.3-2.2-0.90.10.41.41.3-1.7
Area under the delay curve0.50.81.91.31.10.71.0-0.6-0.5-1.0-1.40.7-0.5-1.20.10.6
BMI with tail1.55.411.6-3.0-2.3-3.4-2.01.61.61.42.2-3.22.9-1.51.8-2.0
BMI without tail0.63.27.3-2.1-1.4-2.7-1.31.11.10.51.3-2.62.4-2.01.7-1.3
Body weight3.113.726.8-4.7-3.8-5.2-3.32.92.81.83.3-4.84.6-3.33.0-3.1
Weight adjusted by age0.51.65.7-0.10.3-1.40.7-1.1-1.1-1.20.0-1.41.5-0.71.9-2.4
Bone surface0.71.54.5-0.90.0-1.20.2-1.0-1.0-1.10.8-1.41.60.12.0-2.1
Bone volume1.02.06.1-1.00.2-1.50.3-1.2-1.2-1.30.8-1.62.00.62.3-2.5
Breakpoint value in progressive ratio session0.20.30.80.20.3-0.10.9-0.8-0.6-0.6-0.6-0.00.2-0.10.6-0.9
Number of licking bursts0.20.61.5-0.9-0.3-0.9-0.1-0.2-0.3-0.40.5-1.11.10.51.2-1.2
Context. condit. distance diff. score0.70.82.10.5-0.31.0-0.20.80.80.9-0.61.2-1.3-0.7-1.51.1
Locomotion velocity, session 10.70.83.0-0.8-0.2-1.1-0.20.30.3-0.30.1-1.21.3-1.71.2-0.7
Locomotion distance, session 12.02.65.9-1.9-1.2-2.1-1.11.11.1-0.10.9-2.12.2-2.41.9-1.1
Locomotion velocity, session 20.10.21.8-0.1-0.1-0.00.2-0.0-0.0-0.2-0.4-0.10.1-1.40.3-0.2
Locomotion distance, session 20.91.33.3-0.9-0.3-1.5-0.20.10.0-0.70.4-1.61.7-1.61.8-1.3
Locomotion velocity, session 30.20.20.60.60.30.70.5-0.2-0.3-0.2-0.70.7-0.7-0.0-0.30.2
Locomotion distance, session 30.10.10.3-0.5-0.5-0.3-0.40.50.40.10.3-0.30.2-0.30.3-0.2
Stereotopy head waving bouts, day 31.92.24.42.11.91.61.8-1.8-1.7-1.1-1.61.6-1.30.3-0.60.7
Stereotopy head waving duration, day 30.30.40.80.80.90.40.8-0.9-0.9-0.5-0.60.4-0.1-0.50.10.1
Locomotion velocity, session 71.31.53.0-1.7-1.4-1.5-1.30.80.80.51.6-1.41.30.21.0-1.0
Locomotion distance, session 71.01.32.9-1.4-1.7-0.7-1.61.51.51.11.6-0.60.30.3-0.10.2
Stereotopy head waving bouts, day 70.91.12.31.01.40.21.4-1.4-1.4-1.5-1.20.20.30.10.9-0.7
Stereotopy head waving duration, day 71.21.42.71.21.60.21.7-1.5-1.5-1.7-1.60.20.3-0.71.0-0.6
Locomotion velocity, session 82.22.76.4-1.6-2.1-1.2-1.82.32.21.91.0-1.10.6-2.5-0.40.0
Locomotion distance, session 80.50.73.9-0.8-0.7-0.9-0.50.80.70.10.1-0.80.9-2.00.8-0.6
Degree of sensitization distance1.21.32.8-1.2-1.7-0.5-1.61.61.61.51.5-0.4-0.00.1-0.70.5
Degree of sensitization stereotypy1.01.12.20.91.30.01.4-1.3-1.3-1.5-1.3-0.00.4-0.11.0-0.8
Conditioned locomotion0.40.40.70.80.80.80.8-0.8-0.7-0.8-0.60.7-0.50.5-0.00.1
Cocaine response after cond. corrected1.11.73.70.41.2-1.01.1-1.2-1.2-1.9-0.9-1.01.4-1.31.9-1.4
Cocaine response after cond. not corrected1.21.84.10.31.1-1.11.1-1.4-1.4-2.0-0.6-1.01.4-1.12.0-1.8
Cocaine response before conditioning0.10.10.4-0.1-0.40.3-0.2-0.2-0.20.20.60.4-0.50.6-0.5-0.3
Saline control response0.40.61.6-0.7-0.6-1.3-0.30.10.1-0.10.4-0.80.9-1.00.9-1.2
Bone: connectivity density1.62.56.01.31.90.82.0-2.5-2.4-2.2-1.20.6-0.21.40.9-1.2
Bone: cortical apparent density3.14.910.72.72.23.31.9-1.5-1.4-0.5-2.12.9-2.82.0-2.02.1
Bone: cortical area0.10.21.5-0.00.10.00.2-0.6-0.6-0.50.20.10.11.20.4-0.5
Bone: cortical porosity0.91.02.60.11.0-0.60.8-1.2-1.1-1.4-0.2-0.71.2-0.01.6-1.3
Bone: cortical porosity1.11.23.2-0.10.7-1.10.6-1.0-1.0-1.3-0.1-1.11.5-0.51.8-1.6
Bone: cortical thickness1.01.72.71.61.41.51.5-1.4-1.4-1.2-1.31.5-1.21.4-0.40.2
Bone: cortical thickness4.55.59.83.03.02.13.1-2.9-2.9-2.8-3.02.0-1.30.10.3-0.1
Bone: cortical tissue density3.04.810.42.72.23.21.9-1.4-1.4-0.5-2.12.8-2.82.0-2.02.2
Condit. Reinf. active minus inactive responses1.21.32.91.71.21.41.1-0.6-0.6-0.6-1.61.5-1.40.3-1.00.9
Condit. Reinf. active-inactive response ratio1.81.94.21.81.21.91.1-0.6-0.6-0.6-1.52.0-1.90.9-1.21.2
Condit. Reinf. active responses0.81.12.31.51.11.21.1-0.6-0.6-0.4-1.51.3-1.30.1-1.00.8
Condit. Reinf. inactive responses0.10.10.20.00.3-0.40.3-0.3-0.3-0.1-0.2-0.50.4-0.40.3-0.4
Incentive salience index mean0.91.12.11.51.11.21.0-0.7-0.7-0.8-1.31.3-1.31.0-0.70.6
Condit. Reinf. lever presses0.20.32.00.40.20.40.4-0.5-0.6-0.6-0.20.5-0.41.40.0-0.3
Condit. Reinf. active minus inactive responses0.10.20.50.20.50.30.6-0.7-0.7-0.6-0.40.1-0.00.60.4-0.3
Condit. Reinf. active-inactive response ratio0.10.20.40.00.2-0.00.4-0.6-0.6-0.6-0.1-0.20.20.60.5-0.6
Condit. Reinf. active responses0.40.61.40.30.80.10.9-1.1-1.1-1.2-0.5-0.10.30.70.8-0.7
Condit. Reinf. inactive responses0.40.61.70.51.10.10.9-1.2-1.2-1.3-0.5-0.10.40.30.8-0.5
Condit. Reinf. lever presses0.10.20.50.40.40.70.5-0.3-0.3-0.5-0.50.6-0.4-0.0-0.10.3
Condit. Reinf. lever reinforcers received0.50.71.60.61.00.51.0-1.2-1.2-1.3-0.70.2-0.00.80.6-0.4
Conditioned reinforcement - actives0.10.41.3-0.1-0.60.4-0.60.80.70.50.20.3-0.60.4-0.71.2
Conditioned reinforcement - inactives0.20.41.80.1-0.30.7-0.40.30.30.80.20.5-1.00.4-1.31.1
Conditioned locomotion0.10.21.0-0.2-0.20.2-0.40.80.50.00.1-0.1-0.20.6-0.11.0
Patch foraging indifference point 0 sec0.61.78.00.90.11.80.2-0.4-0.4-0.10.21.8-1.92.8-1.30.8
Patch foraging indifference point AUC0.10.30.80.00.4-0.20.6-0.7-0.7-0.7-0.4-0.40.6-0.40.9-0.9
Delay disc. indifference point, 0s delay0.70.81.61.01.11.01.0-1.1-0.9-1.2-0.70.8-0.51.30.20.3
Delay disc. indifference point, 16s delay1.92.75.92.31.81.71.9-1.3-1.2-1.2-2.41.7-1.3-2.1-0.60.8
Delay disc. indifference point, 2s delay0.20.21.00.20.6-0.10.3-0.3-0.5-1.0-0.2-0.30.40.50.8-0.1
Delay disc. indifference point, 24s delay0.20.41.50.3-0.40.6-0.10.40.50.4-0.30.5-0.8-1.2-0.70.7
Delay disc. indifference point, 4s delay1.51.63.11.61.70.61.7-1.4-1.4-1.8-1.80.5-0.2-1.00.7-0.1
Delay disc. indifference point, 8s delay0.00.00.10.10.00.2-0.10.20.3-0.2-0.00.2-0.20.2-0.10.4
Indifference point function ln k0.20.51.40.70.11.00.00.30.30.2-0.41.2-1.1-0.1-1.01.1
Indifference point function log k0.20.51.40.70.11.00.00.30.30.2-0.41.2-1.1-0.1-1.01.1
Patch foraging total patch changes 0 sec0.51.47.70.4-0.31.6-0.2-0.0-0.00.20.61.5-1.72.8-1.30.8
Patch foraging total patch changes 12 sec1.21.63.80.81.30.81.4-1.9-2.0-1.7-0.50.5-0.22.00.8-0.6
Patch foraging total patch changes 18 sec0.20.43.3-0.3-0.40.40.0-0.5-0.50.10.60.2-0.41.8-0.2-0.5
Patch foraging total patch changes 24 sec0.30.91.90.70.90.71.0-1.4-1.4-1.3-0.40.6-0.21.20.6-0.8
Patch foraging total patch changes 6 sec0.50.84.00.70.31.10.5-0.9-0.9-0.4-0.01.0-1.12.0-0.50.0
Patch foraging time to switch 0 sec0.00.10.30.10.3-0.40.3-0.1-0.2-0.4-0.3-0.30.3-0.50.50.1
Patch foraging water rate 0 sec0.10.20.80.30.10.80.10.00.00.0-0.20.7-0.60.9-0.50.3
Patch foraging water rate 12 sec0.00.10.20.10.20.40.2-0.2-0.1-0.4-0.20.4-0.20.20.1-0.0
Patch foraging water rate 18 sec0.61.33.10.40.90.01.2-1.6-1.7-1.8-0.50.00.60.01.6-1.7
Patch foraging water rate 24 sec0.10.20.50.30.30.60.3-0.4-0.4-0.5-0.10.5-0.40.70.00.1
Patch foraging water rate 6 sec1.01.52.71.31.41.11.6-1.6-1.6-1.6-1.50.9-0.60.30.30.2
Seeking ratio, delayed vs. immediate footshock1.21.73.91.30.51.90.50.00.20.6-1.21.9-1.9-0.2-2.01.8
Distance traveled before self-admin0.30.71.30.40.6-0.51.0-0.8-1.1-0.9-0.7-0.50.6-0.81.0-1.1
Distance traveled after self-admin0.10.21.2-0.2-0.1-0.50.00.20.20.2-0.1-0.50.5-1.10.3-0.5
Extensor digitorum longus weight3.714.929.1-4.5-5.4-2.9-5.05.45.34.93.8-2.31.4-2.3-1.10.5
Bone: elastic displacement0.60.71.4-0.5-0.80.0-1.01.11.21.20.80.1-0.40.7-0.91.1
Bone: elastic work0.20.30.80.10.6-0.40.5-0.6-0.6-0.8-0.3-0.40.6-0.30.9-0.4
Bone: endosteal estimation2.05.09.7-3.0-2.1-3.1-2.01.41.30.82.5-3.02.9-1.12.1-2.0
Bone: endosteal perimeter1.12.75.9-2.4-2.0-1.9-1.91.51.51.32.1-1.91.6-0.10.8-0.7
Epididymis fat weight0.10.61.8-0.8-0.4-1.2-0.20.10.1-0.40.3-1.01.3-0.41.3-1.1
Delta time in closed arm before/after self-admin1.21.12.4-1.3-1.0-1.4-0.80.40.70.71.1-1.31.3-1.60.6-1.1
Delta time in open arm before/after self-admin0.20.20.50.70.50.30.5-0.1-0.30.2-0.60.4-0.3-0.7-0.5-0.1
Diff in mean of infusions in LGA sessions0.10.20.70.00.3-0.20.3-0.5-0.6-0.7-0.1-0.10.40.80.5-0.8
Delay discount exponential model param0.50.71.8-1.2-1.0-0.7-0.90.40.40.91.4-0.70.51.3-0.0-0.5
Extinction: sum of active levers before priming0.50.81.9-1.2-1.1-1.1-0.60.30.40.40.9-1.11.1-0.50.7-1.4
Active lever presses in extinction session 64.24.211.60.21.4-1.81.7-1.9-2.1-2.7-1.1-1.72.5-0.83.4-3.0
Bone: final force1.01.64.8-0.30.7-0.90.7-1.5-1.5-1.80.2-1.01.50.62.2-1.8
Bone: final moment0.91.54.4-0.40.5-1.00.6-1.3-1.3-1.60.3-1.11.60.62.1-1.8
Food consumed during 24 hour testing period0.30.50.9-0.9-0.9-0.8-1.00.90.90.60.9-0.60.5-0.50.1-0.1
Glucose0.50.82.6-0.70.2-0.80.0-0.6-0.6-0.90.7-1.01.40.11.6-1.5
Heart weight1.42.34.7-2.0-2.2-1.4-1.91.81.81.81.9-1.10.9-0.70.1-0.7
Delay discount hyperbolic model param0.40.51.4-1.1-0.8-0.5-0.70.30.30.81.2-0.60.51.1-0.0-0.6
Intermittent access intake day 1-15 change0.10.72.10.81.40.31.1-1.4-1.2-1.0-0.90.10.2-0.30.4-0.4
Intermittent access intake escalation0.10.71.90.81.40.41.1-1.3-1.1-0.9-0.80.10.1-0.40.3-0.3
Intermittent access intake escalation 20.10.10.3-0.30.2-0.40.1-0.10.00.1-0.0-0.60.6-0.50.3-0.1
Intermitt. access day 1 inactive lever presses0.23.06.02.12.31.32.3-2.5-2.4-2.1-1.81.2-0.6-0.10.5-0.5
Intermitt. access day 15 inactive lever presses0.31.73.71.51.11.90.6-0.8-0.5-0.4-0.71.8-1.71.3-1.51.7
Intermitt. access escalation Index0.31.03.5-0.40.1-1.10.4-0.4-0.6-0.7-0.2-0.91.4-1.91.6-1.6
Intermittent access day 1 total infusions0.00.10.20.3-0.10.3-0.10.5-0.00.2-0.20.3-0.5-0.4-0.40.4
Intermittent access day 15 total infusions0.30.81.71.11.30.71.0-0.8-1.1-0.8-1.10.6-0.4-1.1-0.10.1
Intermittent access terminal intake (last 3 days)0.40.61.31.11.20.80.9-0.5-0.8-0.6-1.10.5-0.5-0.9-0.20.4
Intermittent access total infusions0.40.51.30.90.80.70.7-0.3-0.7-0.4-1.00.6-0.6-1.1-0.40.3
Intermittent access day 1 locomotion0.20.30.8-0.2-0.40.3-0.60.90.50.60.40.2-0.40.4-0.60.9
Intermittent access day 15 total locomotion0.00.20.5-0.3-0.0-0.1-0.50.70.70.20.2-0.50.20.20.00.6
Intermittent access total locomotion0.30.30.90.60.60.80.4-0.2-0.2-0.1-0.70.5-0.70.1-0.60.9
Intermittent access standard deviation0.31.53.01.61.71.41.4-1.3-1.3-0.9-1.41.1-1.00.3-0.70.6
Left kidney weight0.10.93.60.00.4-0.70.7-0.4-0.4-0.9-1.1-0.40.9-1.91.3-1.2
Right kidney weight0.32.05.40.01.0-1.11.1-1.3-1.3-1.9-0.8-1.21.7-1.32.3-2.0
Cocaine induced anxiety0.51.35.5-0.7-0.7-1.6-0.50.80.60.10.1-1.31.3-2.41.1-1.3
Post-drug Anxiety0.20.21.50.1-0.3-0.40.00.00.20.2-0.4-0.1-0.0-1.2-0.2-0.9
Baseline Anxiety0.50.93.90.60.21.20.2-0.7-0.30.30.00.9-1.32.0-1.40.5
Tail length0.10.54.1-0.3-0.5-0.4-0.40.90.80.1-0.2-0.30.3-2.00.20.4
Length with tail0.73.15.3-2.1-1.9-2.3-1.51.51.40.51.3-2.02.0-2.31.6-1.5
Length without tail0.94.79.2-3.0-2.8-2.6-2.41.91.81.52.7-2.32.1-0.51.3-1.7
Times rat made contact with spout0.10.11.3-0.2-0.0-0.1-0.1-0.0-0.00.20.4-0.20.11.1-0.1-0.0
Lifetime Intake0.60.81.61.31.01.00.9-0.5-0.9-0.6-1.20.9-0.8-1.1-0.50.4
Liver weight, left0.40.71.2-1.1-1.0-1.1-0.60.40.30.20.7-1.11.0-0.81.0-1.1
Liver weight, right1.52.54.91.72.10.52.0-1.6-1.6-2.2-2.20.40.2-2.11.2-0.7
Locomotor activity0.71.13.9-0.00.9-0.40.9-0.9-1.0-1.6-0.7-0.81.2-0.42.0-1.1
Locomotor testing distance0.61.43.51.21.60.91.6-1.4-1.5-1.9-1.50.6-0.20.50.8-0.2
Locomotor testing rearing1.34.97.92.82.72.72.6-2.2-2.2-2.3-2.72.4-1.91.1-0.41.0
Locomotion in novel chamber1.82.45.32.12.01.12.2-2.3-2.0-1.7-1.81.0-0.80.60.1-0.3
Locomotion in novel chamber post-restriction0.10.20.6-0.30.2-0.80.4-0.4-0.1-0.2-0.2-0.70.70.30.7-0.2
Fecal boli incidents, locomotor time 10.30.91.9-1.1-1.1-0.8-1.31.01.31.41.3-0.80.30.2-0.60.2
Change in fecal boli incidents, locomotor task0.30.30.90.40.70.20.30.1-0.3-1.0-0.80.20.2-0.80.80.2
Time >=10cm from walls, locomotor time 10.50.61.40.60.10.90.40.20.20.1-0.81.1-1.20.9-1.01.1
Bouts of movement, locomotor time 10.30.41.2-0.4-0.2-1.00.1-0.1-0.20.00.0-0.70.7-0.80.6-1.1
Total resting periods, locomotor time 10.70.71.7-1.0-0.8-1.3-0.50.50.40.40.7-1.21.1-0.80.7-1.1
Rest time, locomotor task time 10.40.62.3-1.1-0.8-1.0-0.80.10.20.51.5-0.80.70.50.5-0.4
Distance moved, locomotor task time 10.30.82.61.21.00.51.1-0.7-0.6-0.8-1.60.5-0.3-1.2-0.0-0.1
Vertical activity count, locomotor time 10.00.10.8-0.1-0.1-0.1-0.30.60.40.0-0.1-0.10.1-0.90.00.4
Time >=10cm from walls, locomotor time 20.10.41.70.20.60.20.5-0.3-0.6-1.1-0.40.20.11.30.8-0.2
Bouts of movement, locomotor time 20.20.72.00.70.60.90.9-0.9-1.1-0.9-0.71.0-0.71.40.2-0.2
Total resting periods, locomotor time 20.20.61.60.80.50.80.8-0.9-1.0-0.7-0.71.0-0.71.30.0-0.1
Rest time, locomotor task time 20.30.51.0-1.0-1.0-0.9-0.80.60.60.70.9-0.80.6-0.40.2-0.1
Distance moved, locomotor task time 20.30.41.80.10.4-0.60.4-0.3-0.2-0.6-0.5-0.50.7-1.30.8-0.8
Vertical activity count, locomotor time 20.10.21.3-0.2-0.3-0.4-0.50.80.70.40.2-0.20.1-1.2-0.10.0
Light reinforcement 10.42.03.91.51.71.21.8-2.0-1.9-1.9-1.31.1-0.71.20.4-0.5
Light reinforcement 20.41.02.50.31.0-0.51.0-0.8-0.9-1.5-1.0-0.71.1-1.11.6-0.9
Bone: marrow area1.94.69.0-2.9-2.0-3.0-2.01.31.30.82.4-2.92.8-1.12.0-1.9
Bone: maximum diameter0.20.41.1-0.4-0.0-0.70.0-0.5-0.5-0.50.5-0.70.70.60.9-1.1
Bone: maximum force0.61.13.5-0.9-0.1-1.10.0-0.7-0.8-1.00.8-1.21.50.21.9-1.7
Bone: maximum moment0.61.12.9-1.0-0.2-1.2-0.2-0.5-0.5-0.80.9-1.21.50.21.7-1.6
Mean time between licks in bursts0.52.95.8-2.4-2.3-1.3-2.21.81.81.92.4-1.30.91.1-0.0-0.1
Mean num. licks in bursts0.20.51.60.90.40.80.10.10.20.5-0.40.9-1.00.2-1.31.2
Cd content in liver1.31.43.6-1.0-1.4-0.8-1.61.61.61.91.4-0.70.2-0.1-0.90.6
Co content in liver1.51.85.0-0.6-1.40.0-1.61.91.92.21.20.1-0.70.3-1.81.1
Cu content in liver0.50.61.61.10.40.90.5-0.2-0.20.1-0.71.2-1.20.9-1.30.4
Fe content in liver1.21.53.5-1.2-1.0-1.8-0.90.80.80.20.8-1.51.4-1.91.2-1.4
K content in liver3.13.15.81.92.30.92.4-2.4-2.4-2.2-2.11.0-0.3-0.30.8-1.0
Mg content in liver2.83.05.52.42.22.02.2-1.8-1.8-1.3-2.32.0-1.60.0-0.80.4
Mn content in liver1.71.94.01.61.62.01.5-1.2-1.1-1.0-1.71.8-1.40.5-0.60.7
Na content in liver2.52.96.50.01.4-1.21.4-2.0-2.0-2.1-0.6-1.31.9-0.72.5-2.5
Rb content in liver0.70.82.11.00.41.10.5-0.5-0.5-0.1-0.31.3-1.41.5-1.20.8
Se content in liver5.76.812.43.43.52.53.5-3.2-3.2-2.6-3.42.1-1.60.0-0.20.5
Sr content in liver0.90.82.50.5-0.01.6-0.10.40.40.7-0.21.3-1.30.6-1.31.3
Zn content in liver2.53.06.22.52.31.62.3-2.0-2.0-1.4-2.21.4-1.30.6-0.50.2
Bone: minimum diameter0.50.91.8-1.2-0.7-1.3-0.60.20.20.01.0-1.21.3-0.01.1-1.3
Time in familiar zone, hab. session 11.61.85.4-0.40.6-1.40.6-0.8-0.8-1.7-0.3-1.41.9-1.62.3-1.5
Time in novel zone, hab. session 12.32.57.31.10.12.0-0.10.30.31.4-0.11.9-2.42.1-2.72.1
Total zone transitions, hab. session 10.71.03.0-0.6-1.1-0.5-1.21.61.51.00.5-0.50.2-1.7-0.40.5
Total locomotion distance, hab. session 10.30.41.00.80.30.70.20.30.30.0-0.70.7-0.7-1.0-0.60.9
Locomotion velocity, hab. session 10.20.22.00.40.20.20.10.30.3-0.1-0.60.3-0.2-1.4-0.10.4
Time in familiar zone, hab. session 21.82.14.91.01.7-0.21.8-1.5-1.5-1.8-1.9-0.30.7-2.21.4-0.7
Time in novel zone, hab. session 21.01.17.1-0.1-0.60.8-0.80.50.50.91.20.7-1.02.7-1.20.6
Total zone transitions, hab. session 20.91.22.4-1.3-1.3-0.9-1.41.61.51.01.0-1.00.7-1.10.10.3
Total locomotion distance, hab. session 20.50.71.1-0.9-0.8-0.9-1.01.01.00.60.9-0.90.7-0.80.20.2
Locomotion velocity, hab. session 20.60.81.2-1.0-0.9-0.9-1.11.11.10.61.0-0.90.7-0.90.20.1
Novel to familiar place preference ratio0.10.10.70.40.00.10.20.10.00.0-0.40.4-0.3-0.9-0.2-0.1
Novelty place preference0.10.20.50.50.00.40.10.20.10.2-0.40.7-0.7-0.6-0.50.2
Time in novel zone, NPP test0.20.30.60.80.40.60.4-0.2-0.2-0.1-0.70.8-0.7-0.5-0.40.2
Total zone transitions, NPP test1.42.03.6-1.9-1.6-1.7-1.51.51.40.51.3-1.81.5-1.41.1-0.6
Total locomotion distance, NPP test0.50.71.2-1.1-0.8-1.0-0.90.90.90.20.9-1.11.0-0.80.8-0.2
Locomotion velocity, NPP test0.91.22.1-1.4-1.3-1.1-1.41.41.40.71.1-1.10.9-1.10.40.0
Intraocular pressure2.74.49.6-1.7-2.7-1.3-2.63.13.03.11.7-1.20.0-1.7-1.50.9
Delta distance traveled before/after self-admin0.40.41.2-0.4-0.5-0.0-0.70.91.01.00.2-0.10.0-1.1-0.50.5
Delta ambulatory time before/after self-admin0.40.72.4-0.9-0.6-0.9-0.80.81.00.70.4-0.90.9-1.60.4-0.2
Parametrial fat weight0.30.82.10.20.8-0.80.5-0.8-0.8-1.3-0.1-0.71.00.51.5-1.0
Pavlov. Cond. lever latency0.70.92.3-0.2-0.60.6-0.71.11.11.50.10.5-0.8-0.7-1.31.5
Pavlov. Cond. magazine entry latency3.54.49.42.12.81.02.7-3.1-3.1-3.0-2.00.7-0.11.51.1-1.1
Pavlov. Cond. change in total contacts4.44.88.83.02.52.42.6-2.3-2.4-2.0-2.42.4-2.01.7-0.80.6
Pavlov. Cond. index score2.02.65.51.51.90.62.0-2.3-2.4-2.3-1.30.4-0.01.61.0-1.1
Pavlov. Cond. latency score1.62.14.81.11.60.21.7-2.1-2.2-2.2-0.90.10.31.41.2-1.4
Pavlov. Cond. lever contacts0.70.82.00.20.6-0.40.7-1.1-1.2-1.4-0.2-0.50.71.01.2-1.4
Pavlov. Cond. magazine entry number4.15.29.1-2.7-3.0-1.8-3.03.03.02.82.5-1.61.1-1.8-0.30.3
Pavlov. Cond. intertrial magazine entries0.60.72.1-0.4-0.9-0.1-0.91.21.21.40.40.0-0.4-1.0-1.00.8
Pavlov. Cond. lever-magazine prob. diff.2.43.06.31.72.20.92.2-2.5-2.5-2.5-1.50.7-0.31.80.8-0.9
Pavlov. Cond. response bias3.44.27.72.32.61.52.6-2.7-2.8-2.8-2.11.3-0.81.70.7-0.7
Pavlov. Cond. lever latency0.10.20.5-0.2-0.6-0.2-0.40.50.50.70.2-0.0-0.2-0.2-0.6-0.0
Pavlov. Cond. magazine entry latency0.10.10.4-0.3-0.2-0.3-0.30.30.30.30.2-0.50.3-0.70.20.0
Pavlov. Cond. change in total contacts0.20.41.80.30.31.10.1-0.1-0.00.1-0.10.7-0.80.7-0.71.3
Pavlov. Cond. index score0.00.00.1-0.30.1-0.0-0.10.10.1-0.10.1-0.30.3-0.20.30.3
Pavlov. Cond. latency score0.00.10.1-0.3-0.0-0.0-0.20.20.20.00.3-0.40.3-0.30.30.3
Pavlov. Cond. lever contacts0.10.20.60.00.4-0.00.3-0.5-0.5-0.8-0.1-0.20.30.10.7-0.1
Pavlov. Cond. magazine entry number0.10.10.4-0.1-0.4-0.0-0.30.20.20.30.40.2-0.20.6-0.3-0.1
Pavlov. Cond. intertrial magazine entries0.51.12.3-0.2-1.30.7-1.01.41.31.30.50.9-1.20.0-1.51.0
Pavlov. Cond. lever-magazine prob. diff.0.00.00.1-0.30.0-0.0-0.20.20.2-0.00.2-0.30.3-0.30.30.3
Pavlov. Cond. response bias0.30.40.90.40.90.20.7-0.8-0.8-1.0-0.6-0.00.20.20.7-0.2
Time in closed arm before self-admin0.91.53.61.51.21.90.8-0.4-0.6-0.8-1.31.6-1.5-0.0-0.81.9
Time in closed arm after self-admin0.50.62.10.70.61.40.5-0.5-0.4-0.3-0.61.1-0.9-0.8-0.60.8
Time in open arm before self-admin0.50.71.6-1.0-0.6-1.2-0.30.00.4-0.10.3-0.91.2-0.41.3-1.1
Time in open arm after self-admin0.10.10.3-0.3-0.4-0.3-0.20.30.40.60.1-0.20.2-0.0-0.1-0.3
Bone: periosteal estimation0.71.63.4-1.5-0.8-1.8-0.70.10.0-0.21.4-1.71.80.01.7-1.7
Bone: periosteal perimeter1.01.93.8-1.9-1.3-1.9-1.20.80.70.41.6-1.81.80.01.4-1.4
Bone: post-yield work0.50.92.1-1.4-1.4-0.8-1.21.00.90.61.4-0.70.60.10.4-0.3
Progressive ratio test 1 active lever presses0.10.20.70.60.50.30.5-0.1-0.5-0.4-0.60.2-0.2-0.90.10.2
Progressive ratio test 1 breakpoint0.10.10.60.50.40.30.30.0-0.4-0.3-0.50.2-0.2-0.8-0.00.2
Progressive ratio test 1 inactive lever presses0.20.61.11.10.80.90.9-1.0-1.0-0.7-0.90.9-0.7-0.3-0.20.1
Progressive ratio test 2 active lever presses0.20.30.50.70.50.70.5-0.4-0.6-0.3-0.40.5-0.70.4-0.50.4
Progressive ratio test 2 breakpoint0.20.30.60.70.60.70.5-0.5-0.6-0.4-0.50.4-0.60.4-0.40.4
Progressive ratio test 2 inactive lever presses0.00.10.50.40.20.5-0.00.3-0.00.1-0.20.4-0.5-0.0-0.60.7
Incentive Sensitization - Responses0.10.43.30.1-0.10.5-0.30.10.20.20.50.2-0.61.8-0.70.6
Incentive Sensitization - Breakpoint0.10.32.60.1-0.00.4-0.20.00.10.10.40.1-0.51.6-0.60.5
Sum of active levers in priming session hrs 5-61.21.22.20.51.1-0.61.1-1.3-1.2-1.4-1.0-0.40.9-1.01.5-1.4
Progressive ratio0.20.61.20.10.6-0.20.8-1.0-0.9-1.0-0.7-0.30.6-0.91.1-0.8
Food seeking constrained by brief footshock0.40.61.50.30.9-0.30.6-0.7-1.0-1.2-0.8-0.10.7-0.51.2-0.3
Seeking ratio, punishment vs. effort0.10.10.50.1-0.10.0-0.30.60.40.30.00.2-0.30.2-0.40.7
Retroperitoneal fat weight0.00.10.30.20.2-0.00.1-0.0-0.1-0.5-0.20.10.10.00.5-0.2
Reaction time number correct0.20.82.0-1.4-1.2-1.0-1.00.50.50.61.4-0.80.80.10.6-0.7
Reaction time mean minus median0.21.43.2-1.0-1.4-0.3-1.61.41.41.81.6-0.3-0.20.7-1.21.1
Reaction time mean minus median AUC0.10.71.6-0.5-0.80.1-1.00.80.81.31.2-0.1-0.30.9-1.00.8
Reaction time num false alarms0.40.72.0-0.60.2-0.80.5-0.8-0.8-0.9-0.1-0.91.1-0.41.4-1.3
Reaction time num false alarms AUC0.30.62.0-0.9-0.1-0.90.0-0.4-0.4-0.70.4-1.01.10.11.4-1.2
Reaction time trials correct on left0.20.82.0-1.4-1.2-1.0-1.00.50.50.61.4-0.80.80.10.6-0.7
Reaction time trials on left0.20.82.0-1.4-1.2-1.0-1.00.50.50.61.4-0.80.80.10.6-0.7
Reaction time mean0.40.91.81.20.91.10.7-0.4-0.4-0.0-1.01.1-1.2-0.1-1.21.3
Reaction time mean AUC0.40.91.81.41.01.10.9-0.6-0.6-0.1-1.01.1-1.20.0-1.21.1
Median of all reaction times1.21.93.81.91.71.41.6-1.2-1.2-0.8-1.81.4-1.4-0.1-1.01.2
Reaction time omissions0.20.30.50.60.60.70.6-0.7-0.7-0.3-0.50.5-0.50.2-0.30.1
Reaction time false alarm rate0.30.41.0-0.10.6-0.30.6-0.8-0.8-1.0-0.4-0.50.60.11.0-0.8
Reaction time premature initiation rate1.92.96.11.72.20.22.4-2.0-2.1-2.1-2.50.30.3-1.71.1-0.9
Reaction time premature initiations0.41.22.40.71.1-0.31.4-1.3-1.4-1.3-1.3-0.10.6-1.51.1-1.0
Std. dev. reaction times0.10.30.9-0.2-0.30.1-0.50.40.41.00.6-0.0-0.30.5-0.90.9
Reaction time trials completed0.20.82.0-1.4-1.2-1.0-1.00.50.50.61.4-0.80.80.10.6-0.7
Reaction time trials AUC0.20.72.1-1.4-1.2-0.8-1.10.60.60.81.5-0.60.60.30.4-0.4
Run reversals in cocaine runway, females0.40.51.60.8-0.10.50.00.40.20.3-0.51.0-1.0-1.3-0.90.0
Run reversals in cocaine runway, males0.10.10.40.70.40.10.3-0.3-0.20.0-0.60.3-0.4-0.3-0.40.1
Latency to leave start box in cocaine runway0.40.51.5-0.8-0.9-0.2-0.91.21.01.10.70.0-0.00.0-0.40.5
Latency to leave start box in cocaine runway, F0.20.30.6-0.6-0.8-0.6-0.60.60.40.80.4-0.30.3-0.8-0.1-0.4
Latency to leave start box in cocaine runway, M0.50.41.40.0-0.00.8-0.30.70.70.30.10.8-0.71.1-0.61.2
Std. dev. time between licks in bursts0.30.51.3-1.1-0.7-0.6-0.70.20.20.21.1-0.80.81.00.6-0.5
Total sessions with >9 infusions1.01.32.71.40.91.70.9-0.5-0.9-0.5-1.31.6-1.4-1.0-0.90.9
Short access day 1 total inactive lever presses0.51.02.31.51.11.30.9-0.6-1.0-0.6-1.01.1-1.20.0-0.80.9
Short access day 10 total inactive lever presses0.00.20.70.0-0.40.3-0.30.10.20.40.30.5-0.60.7-0.80.3
Short access day 1 total infusions1.22.44.52.11.71.61.8-1.2-1.7-1.3-2.11.6-1.2-1.8-0.30.3
Short access day 10 total infusions0.30.51.00.90.90.70.9-0.7-0.9-0.6-1.00.6-0.5-0.7-0.10.4
Short access total infusions1.11.53.21.61.41.11.5-1.0-1.5-1.1-1.81.1-0.8-1.4-0.10.1
Short access day 1 locomotion0.91.42.61.61.41.51.4-1.1-1.2-1.4-1.51.4-0.9-0.50.00.4
Short access day 10 total locomotion0.10.31.60.10.50.5-0.10.40.4-0.1-0.0-0.0-0.21.2-0.21.3
Short access total locomotion0.10.20.90.30.20.8-0.10.30.1-0.0-0.10.5-0.50.2-0.40.9
One hour access (0.3 mA shock)0.10.10.6-0.1-0.30.1-0.50.80.30.50.30.2-0.30.0-0.40.3
Compulsive drug intake1.11.65.40.6-0.31.8-0.30.20.21.1-0.22.0-2.10.6-2.31.3
One hour access (shock baseline)0.10.30.60.40.7-0.30.5-0.2-0.6-0.8-0.5-0.30.5-0.80.8-0.5
Social response proportion0.10.21.3-0.1-0.2-0.5-0.10.40.3-0.1-0.2-0.20.3-1.10.3-0.0
Social responses0.30.41.5-0.30.1-0.80.10.10.0-0.8-0.2-0.81.0-1.11.2-0.3
Social time0.91.44.1-1.4-0.9-2.0-1.00.50.50.21.5-1.71.60.31.1-1.1
Soleus weight0.82.45.7-1.7-0.5-2.2-0.4-0.2-0.2-0.71.1-2.22.4-1.02.4-2.0
Bone: stiffness0.61.23.20.00.7-0.70.8-1.2-1.3-1.6-0.2-0.61.2-0.31.8-1.7
Tibialis anterior weight0.72.36.0-1.6-1.4-2.3-1.11.11.00.70.8-1.91.8-2.41.1-1.4
Time to tail flick, vehicle, before self-admin1.21.53.4-1.2-1.5-0.4-1.61.81.51.41.3-0.70.01.4-0.71.0
Time to tail flick, vehicle, after self-admin0.40.82.7-0.8-0.8-0.8-0.90.30.0-0.01.4-0.90.71.70.5-1.0
Time to tail flick, test, before self-admin0.50.61.6-0.7-0.6-0.8-0.60.90.80.40.3-1.00.7-1.20.4-0.1
Time to tail flick, test, after self-admin0.70.81.5-1.2-0.9-0.8-0.90.71.00.61.1-1.10.81.00.4-0.1
Delta time to tail flick, vehicle, before/after SA1.11.23.5-0.40.3-1.20.1-1.0-0.8-1.00.8-1.21.31.11.5-1.9
Delta time to tail flick, test, before/after SA0.30.32.40.30.30.60.2-0.4-0.1-0.2-0.10.5-0.51.6-0.30.5
Tibia length1.23.27.3-2.1-1.5-2.7-1.20.90.80.41.4-2.52.5-1.81.8-2.1
Ambulatory time before self-admin0.00.10.30.40.20.10.4-0.1-0.5-0.3-0.30.1-0.0-0.10.1-0.4
Ambulatory time after self-admin0.60.94.0-0.7-0.5-1.2-0.40.60.40.30.2-1.21.3-2.00.9-0.9
Bone: tissue strength1.61.63.6-1.6-1.9-0.4-1.81.51.51.61.9-0.40.01.0-0.60.2
Total heroin consumption1.41.74.10.21.1-0.61.3-1.5-1.6-1.9-0.9-0.81.20.82.0-1.4
Bone: trabecular number2.24.29.61.52.60.42.4-3.1-3.0-3.1-1.40.20.51.61.8-1.9
Bone: trabecular spacing1.32.04.0-1.6-1.4-2.0-1.41.61.50.81.0-1.71.6-1.50.8-0.5
Bone: trabecular thickness0.10.21.1-0.5-0.1-0.2-0.1-0.3-0.2-0.10.4-0.30.31.10.3-0.4
Bone: trabecular tissue density0.91.64.01.0-0.01.8-0.10.50.50.8-0.31.9-2.00.4-1.91.8
Water consumed over 24 hours0.30.61.5-1.2-0.9-0.8-1.10.90.90.61.2-0.60.50.40.2-0.2
Number of responses in last shaping day0.81.12.70.80.61.60.2-0.0-0.30.4-0.61.5-1.40.3-1.61.6