Hub : Genes

Krt222

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc mRNA stability Krt222 0.02 0.02 4.7e-03 0.02 0.01 0.01 0.01 2.8e-03 1.0e-02 1.3e-02 1.8e-02
2 LHb mRNA stability Krt222 0.29 0.15 7.5e-05 0.24 0.18 0.17 0.02 2.4e-06 4.6e-05 6.8e-05 1.2e-01
3 NAcc gene expression Krt222 0.16 0.06 0.0e+00 0.17 0.15 0.15 0.16 8.6e-19 2.6e-17 2.1e-17 2.4e-18
4 OFC mRNA stability Krt222 0.22 0.14 3.8e-03 0.09 0.04 0.02 -0.01 4.7e-03 4.3e-02 1.0e-01 5.6e-01
5 Adipose gene expression Krt222 0.18 0.08 0.0e+00 0.15 0.16 0.18 0.18 1.2e-16 6.6e-18 1.6e-19 3.6e-19
6 Liver gene expression Krt222 0.03 0.02 3.0e-05 0.04 0.04 0.03 0.04 1.4e-05 2.1e-05 1.5e-04 3.7e-05
7 Brain mRNA stability Krt222 0.03 0.02 8.4e-04 0.04 0.02 0.02 0.03 3.2e-04 3.2e-03 2.8e-03 1.1e-03
8 PL mRNA stability Krt222 0.05 0.03 8.4e-05 0.04 0.03 0.03 0.04 1.5e-05 6.9e-04 6.6e-04 4.9e-05
9 OFC gene expression Krt222 0.61 0.17 1.8e-03 -0.01 0.08 0.04 -0.01 9.4e-01 7.1e-03 4.5e-02 6.6e-01
10 PL gene expression Krt222 0.2 0.08 4.3e-09 0.05 0.08 0.07 0.06 7.5e-06 6.3e-09 2.6e-08 1.0e-06
11 Brain alternative TSS NM_001398856.1 0.04 0.03 9.5e-03 -0 0.01 -0 -0 5.3e-01 2.8e-02 3.7e-01 4.6e-01
12 Brain gene expression Krt222 0.09 0.05 6.3e-04 0.04 0.03 0.02 0.02 2.8e-04 1.5e-03 2.5e-03 5.2e-03
13 BLA gene expression Krt222 0.16 0.09 1.5e-03 0.05 0.05 0.02 0.04 7.6e-04 1.5e-03 3.3e-02 2.9e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density1.22.06.0-1.6-2.4-2.4-2.4-0.7-1.0-1.0-1.00.71.00.4-0.6-0.7
Area under the delay curve0.60.61.2-0.2-0.9-0.9-0.9-0.6-1.1-1.1-1.1-0.1-0.0-1.00.50.5
BMI with tail1.24.010.03.21.81.81.82.92.12.22.21.91.51.2-1.2-1.2
BMI without tail0.10.30.80.90.80.80.80.40.70.50.5-0.1-0.20.20.10.1
Body weight2.18.822.94.82.42.42.44.53.03.23.23.22.51.7-1.6-1.6
Weight adjusted by age1.21.33.51.0-0.6-0.6-0.61.50.10.00.01.91.80.4-1.8-1.8
Bone surface0.71.23.30.4-1.0-1.0-1.01.10.40.50.51.71.81.3-1.2-1.2
Bone volume1.01.74.20.3-1.2-1.2-1.21.20.40.50.51.92.01.6-1.6-1.7
Breakpoint value in progressive ratio session0.10.20.7-0.8-0.5-0.5-0.5-0.1-0.2-0.2-0.40.30.40.2-0.3-0.3
Number of licking bursts0.70.82.50.2-0.2-0.2-0.20.90.60.30.30.91.31.6-1.3-1.4
Context. condit. distance diff. score1.41.75.60.50.60.60.6-0.9-0.5-0.6-0.6-1.3-1.6-2.12.42.2
Locomotion velocity, session 10.50.51.51.0-0.0-0.0-0.01.20.30.10.11.21.20.5-0.9-0.6
Locomotion distance, session 11.72.25.72.20.60.60.62.41.20.90.92.01.91.2-1.5-1.4
Locomotion velocity, session 20.10.10.20.1-0.1-0.1-0.10.2-0.4-0.5-0.50.20.3-0.2-0.10.2
Locomotion distance, session 21.01.43.50.9-0.4-0.4-0.41.60.40.40.41.71.91.2-1.8-1.7
Locomotion velocity, session 30.30.30.6-0.8-0.1-0.1-0.1-0.8-0.4-0.7-0.7-0.6-0.4-0.60.70.5
Locomotion distance, session 30.10.10.20.20.40.40.40.30.40.30.30.10.20.2-0.2-0.3
Stereotopy head waving bouts, day 31.61.93.4-1.9-1.5-1.5-1.5-1.6-1.7-1.6-1.6-0.6-0.6-1.30.70.7
Stereotopy head waving duration, day 30.30.40.8-0.3-0.9-0.9-0.9-0.4-0.8-0.6-0.60.30.0-0.80.40.4
Locomotion velocity, session 71.51.73.01.31.01.01.01.51.71.71.71.00.91.5-1.0-1.1
Locomotion distance, session 71.11.42.60.91.41.41.40.91.61.61.6-0.2-0.11.3-0.4-0.5
Stereotopy head waving bouts, day 70.80.92.0-0.6-1.4-1.4-1.4-0.2-1.1-1.1-1.10.90.9-0.5-0.2-0.2
Stereotopy head waving duration, day 71.21.42.6-0.5-1.6-1.6-1.6-0.2-1.5-1.6-1.61.11.0-0.9-0.2-0.2
Locomotion velocity, session 81.72.07.32.72.02.02.01.41.10.90.90.0-0.4-0.80.60.7
Locomotion distance, session 80.20.41.91.40.40.40.41.00.2-0.0-0.00.70.7-0.20.00.0
Degree of sensitization distance1.31.32.41.21.61.61.60.61.41.51.5-0.6-0.70.60.30.2
Degree of sensitization stereotypy0.91.01.8-0.6-1.4-1.4-1.4-0.2-1.2-1.3-1.30.90.9-0.4-0.5-0.5
Conditioned locomotion0.40.50.9-0.5-0.9-0.9-0.9-0.6-0.8-0.7-0.70.0-0.0-0.60.50.5
Cocaine response after cond. corrected1.51.73.60.1-1.5-1.5-1.50.8-0.8-0.8-0.81.81.90.2-1.6-1.6
Cocaine response after cond. not corrected1.61.83.7-0.1-1.7-1.7-1.70.8-0.5-0.5-0.51.81.90.5-1.6-1.7
Cocaine response before conditioning0.20.20.4-0.5-0.1-0.1-0.1-0.50.50.60.6-0.6-0.60.40.40.3
Saline control response0.40.51.70.8-0.2-0.2-0.21.10.20.20.21.31.20.5-0.9-0.9
Bone: connectivity density1.62.56.8-2.1-2.6-2.6-2.6-1.1-1.3-1.3-1.30.40.70.3-0.4-0.4
Bone: cortical apparent density3.14.010.3-3.2-1.0-1.0-1.0-3.1-2.2-2.0-2.0-2.5-2.1-1.21.41.4
Bone: cortical area0.00.10.2-0.4-0.2-0.2-0.2-0.00.20.30.30.10.20.4-0.1-0.1
Bone: cortical porosity0.80.92.20.1-1.1-1.1-1.10.80.40.30.31.51.50.6-1.0-1.0
Bone: cortical porosity1.11.23.10.4-1.2-1.2-1.21.10.30.30.31.81.70.6-1.3-1.3
Bone: cortical thickness0.81.33.0-1.7-1.3-1.3-1.3-1.5-1.2-1.1-1.1-0.7-0.6-0.90.80.7
Bone: cortical thickness5.15.910.5-2.7-3.1-3.1-3.1-2.4-3.2-3.1-3.1-0.30.0-1.90.90.9
Bone: cortical tissue density3.04.010.2-3.2-1.0-1.0-1.0-3.1-2.2-2.0-2.0-2.5-2.1-1.21.41.4
Condit. Reinf. active minus inactive responses1.41.62.7-1.6-0.9-0.9-0.9-1.6-1.4-1.6-1.6-1.2-0.9-1.40.90.7
Condit. Reinf. active-inactive response ratio2.02.24.3-1.9-1.0-1.0-1.0-2.1-1.5-1.5-1.5-1.5-1.3-1.51.61.3
Condit. Reinf. active responses1.01.22.6-1.6-0.6-0.6-0.6-1.5-1.2-1.5-1.5-1.2-0.9-1.10.70.4
Condit. Reinf. inactive responses0.10.10.7-0.10.00.00.00.2-0.0-0.3-0.30.20.40.2-0.8-0.8
Incentive salience index mean0.91.13.5-1.9-0.9-0.9-0.9-1.5-1.0-1.3-1.3-1.1-0.7-0.50.40.2
Condit. Reinf. lever presses0.20.20.9-0.9-0.1-0.1-0.1-0.40.40.10.1-0.5-0.10.8-0.4-0.6
Condit. Reinf. active minus inactive responses0.30.30.9-0.9-0.7-0.7-0.7-0.3-0.1-0.4-0.4-0.10.41.0-0.6-0.6
Condit. Reinf. active-inactive response ratio0.30.41.4-0.4-0.5-0.5-0.50.20.20.10.10.10.51.2-1.0-0.9
Condit. Reinf. active responses0.60.81.4-1.2-1.1-1.1-1.1-0.2-0.2-0.5-0.50.40.91.2-1.1-1.1
Condit. Reinf. inactive responses0.70.91.7-1.3-1.2-1.2-1.2-0.3-0.6-0.8-0.80.60.90.6-0.9-0.9
Condit. Reinf. lever presses0.20.20.5-0.7-0.5-0.5-0.5-0.5-0.4-0.7-0.7-0.10.1-0.10.30.3
Condit. Reinf. lever reinforcers received0.60.82.1-1.4-1.2-1.2-1.2-0.5-0.5-0.8-0.80.20.70.8-0.7-0.8
Conditioned reinforcement - actives0.20.20.6-0.8-0.0-0.0-0.0-0.7-0.0-0.1-0.1-0.7-0.60.40.20.2
Conditioned reinforcement - inactives0.80.93.3-1.20.10.10.1-1.5-0.2-0.2-0.1-1.8-1.70.20.90.9
Conditioned locomotion0.20.21.0-0.40.30.30.3-0.00.50.20.2-0.20.21.0-0.6-0.6
Patch foraging indifference point 0 sec0.81.35.3-2.3-0.3-0.3-0.3-1.9-0.2-0.1-0.1-1.8-1.40.31.01.0
Patch foraging indifference point AUC0.10.10.40.3-0.1-0.1-0.10.40.10.00.00.60.60.3-0.4-0.4
Delay disc. indifference point, 0s delay0.40.51.0-0.9-1.0-1.0-1.0-0.7-0.7-0.5-0.8-0.00.3-0.10.30.2
Delay disc. indifference point, 16s delay3.23.27.7-0.7-1.5-1.5-1.5-1.5-2.5-2.4-2.4-0.5-0.6-2.81.71.7
Delay disc. indifference point, 2s delay0.30.30.6-0.4-0.7-0.7-0.70.10.10.0-0.10.60.80.8-0.7-0.7
Delay disc. indifference point, 24s delay0.30.30.70.20.40.40.4-0.4-0.3-0.2-0.1-0.8-0.7-0.60.70.7
Delay disc. indifference point, 4s delay1.71.83.7-0.4-1.8-1.8-1.8-0.5-1.9-1.8-1.80.80.8-1.10.10.1
Delay disc. indifference point, 8s delay0.00.00.0-0.1-0.1-0.1-0.1-0.20.00.10.1-0.2-0.00.10.10.1
Indifference point function ln k0.40.61.5-0.5-0.1-0.1-0.1-0.9-0.5-0.4-0.3-0.9-1.0-1.01.21.2
Indifference point function log k0.40.61.5-0.5-0.1-0.1-0.1-0.9-0.5-0.4-0.3-0.9-1.0-1.01.21.2
Patch foraging total patch changes 0 sec0.61.04.0-2.0-0.1-0.1-0.1-1.60.10.20.2-1.7-1.30.51.00.9
Patch foraging total patch changes 12 sec1.21.55.1-2.2-1.6-1.6-1.6-1.0-0.4-0.7-0.70.20.81.4-0.9-0.9
Patch foraging total patch changes 18 sec0.20.21.0-1.00.00.00.0-0.40.50.30.3-0.5-0.11.0-0.2-0.3
Patch foraging total patch changes 24 sec0.70.82.2-1.5-1.4-1.4-1.4-0.7-0.8-0.7-0.70.30.60.2-0.2-0.3
Patch foraging total patch changes 6 sec0.50.73.6-1.9-0.7-0.7-0.7-1.3-0.6-0.5-0.5-0.9-0.50.40.30.3
Patch foraging time to switch 0 sec0.10.20.3-0.1-0.5-0.5-0.50.1-0.2-0.4-0.40.40.50.1-0.4-0.4
Patch foraging water rate 0 sec0.10.10.4-0.70.10.10.1-0.6-0.10.10.0-0.5-0.5-0.10.30.3
Patch foraging water rate 12 sec0.10.10.4-0.6-0.4-0.4-0.4-0.3-0.1-0.0-0.00.0-0.0-0.10.30.3
Patch foraging water rate 18 sec0.70.92.0-0.7-1.4-1.4-1.40.2-0.6-0.4-0.41.21.40.5-0.8-0.8
Patch foraging water rate 24 sec0.10.20.9-0.9-0.5-0.5-0.5-0.5-0.00.10.0-0.3-0.10.50.10.0
Patch foraging water rate 6 sec0.81.12.8-1.7-1.5-1.5-1.5-1.0-1.0-1.1-1.1-0.00.2-0.10.0-0.1
Seeking ratio, delayed vs. immediate footshock2.32.74.9-1.4-0.2-0.2-0.2-2.1-1.5-1.4-1.3-2.2-2.2-2.02.12.0
Distance traveled before self-admin0.20.20.50.1-0.3-0.3-0.30.5-0.2-0.2-0.10.70.60.2-0.7-0.7
Distance traveled after self-admin0.30.31.31.10.70.70.70.90.20.20.30.60.3-0.2-0.2-0.2
Extensor digitorum longus weight3.212.529.65.44.94.94.93.44.23.93.90.2-0.60.50.80.9
Bone: elastic displacement0.40.50.8-0.10.90.90.9-0.10.70.80.8-0.9-0.80.50.20.2
Bone: elastic work0.30.30.7-0.2-0.9-0.9-0.90.3-0.2-0.3-0.30.70.80.2-0.6-0.6
Bone: endosteal estimation2.34.99.92.91.31.31.33.22.42.42.42.52.22.2-1.9-1.9
Bone: endosteal perimeter1.32.64.31.91.71.71.71.92.12.02.01.00.91.7-0.9-0.8
Epididymis fat weight0.30.82.20.20.20.20.20.71.11.51.40.90.81.5-0.6-0.6
Delta time in closed arm before/after self-admin1.01.04.02.01.11.11.11.40.90.91.10.60.3-0.2-0.1-0.1
Delta time in open arm before/after self-admin0.10.10.5-0.1-0.3-0.3-0.3-0.3-0.4-0.4-0.4-0.2-0.5-0.70.30.3
Diff in mean of infusions in LGA sessions0.10.20.6-0.8-0.4-0.4-0.40.00.20.30.20.40.30.3-0.4-0.4
Delay discount exponential model param0.60.61.30.00.80.80.80.51.11.11.10.10.01.1-0.5-0.5
Extinction: sum of active levers before priming1.31.32.61.60.90.90.91.41.51.51.41.00.81.0-0.6-0.6
Active lever presses in extinction session 64.94.811.3-0.8-2.5-2.5-2.51.2-1.1-1.0-1.03.33.41.0-2.8-2.8
Bone: final force1.32.14.9-0.1-1.6-1.6-1.61.00.20.20.22.12.21.4-1.8-1.8
Bone: final moment1.21.94.50.0-1.4-1.4-1.41.20.40.40.42.12.11.4-1.8-1.8
Food consumed during 24 hour testing period0.40.51.11.00.90.90.90.80.80.80.80.30.20.30.10.0
Glucose0.20.30.90.2-0.7-0.7-0.70.30.10.20.20.90.90.5-0.3-0.3
Heart weight1.62.34.72.02.22.22.21.31.81.71.7-0.3-0.60.30.60.6
Delay discount hyperbolic model param0.60.61.20.10.90.90.90.51.11.11.10.0-0.01.0-0.5-0.5
Intermittent access intake day 1-15 change0.70.71.5-0.7-1.1-1.1-1.1-0.9-1.2-1.1-1.1-0.1-0.1-0.60.40.4
Intermittent access intake escalation0.90.92.0-0.7-1.3-1.3-1.3-0.8-1.4-1.3-1.30.10.1-0.70.20.2
Intermittent access intake escalation 20.10.10.20.1-0.3-0.3-0.3-0.0-0.3-0.4-0.40.30.3-0.1-0.2-0.2
Intermitt. access day 1 inactive lever presses2.52.65.9-1.5-2.4-2.4-2.4-1.0-2.2-1.8-1.80.90.8-1.0-0.1-0.1
Intermitt. access day 15 inactive lever presses2.22.45.8-2.4-1.9-1.9-1.9-1.9-1.8-1.5-1.5-0.7-0.6-0.80.50.5
Intermitt. access escalation Index0.70.62.41.3-0.2-0.2-0.21.20.10.20.21.61.3-0.3-0.3-0.3
Intermittent access day 1 total infusions0.00.00.2-0.2-0.2-0.2-0.2-0.1-0.4-0.1-0.1-0.00.00.0-0.2-0.2
Intermittent access day 15 total infusions1.31.43.5-0.7-1.5-1.5-1.5-1.0-1.9-1.6-1.6-0.0-0.1-1.20.60.6
Intermittent access terminal intake (last 3 days)0.80.92.1-0.5-1.2-1.2-1.2-0.7-1.4-1.3-1.30.00.0-0.80.20.2
Intermittent access total infusions0.50.51.3-0.2-0.9-0.9-0.9-0.5-1.1-1.0-1.00.0-0.1-0.80.20.2
Intermittent access day 1 locomotion0.30.30.5-0.30.60.60.6-0.40.40.60.7-0.7-0.60.50.20.2
Intermittent access day 15 total locomotion0.40.40.90.10.90.90.9-0.20.60.60.7-0.8-0.60.9-0.1-0.1
Intermittent access total locomotion0.30.31.0-0.60.20.20.2-0.9-0.2-0.2-0.2-1.0-0.90.10.40.4
Intermittent access standard deviation1.51.63.3-1.8-1.2-1.2-1.2-1.8-1.5-1.4-1.4-1.1-0.9-0.90.80.8
Left kidney weight0.30.82.70.8-0.5-0.5-0.50.5-0.8-1.0-1.01.10.6-1.61.00.9
Right kidney weight0.71.85.50.9-1.5-1.5-1.51.0-1.3-1.0-1.12.32.0-0.7-0.7-0.7
Cocaine induced anxiety1.72.05.81.8-0.3-0.3-0.32.20.1-0.1-0.12.42.30.1-1.8-1.8
Post-drug Anxiety0.50.51.10.6-0.6-0.6-0.60.8-0.7-0.6-0.61.10.9-0.6-0.8-0.8
Baseline Anxiety1.41.54.6-1.40.20.20.2-1.9-0.4-0.4-0.3-2.2-2.1-0.51.41.4
Tail length0.00.10.60.50.20.20.2-0.0-0.2-0.4-0.3-0.1-0.3-0.80.50.5
Length with tail0.41.35.42.30.80.80.81.90.80.80.81.61.0-0.30.0-0.1
Length without tail1.22.78.42.40.20.20.22.71.01.31.22.92.40.8-1.2-1.2
Times rat made contact with spout0.20.20.8-0.60.20.20.2-0.10.50.40.4-0.4-0.20.9-0.6-0.6
Lifetime Intake0.80.92.2-0.4-1.2-1.2-1.2-0.6-1.5-1.4-1.30.20.0-1.00.30.3
Liver weight, left0.00.00.1-0.1-0.3-0.3-0.3-0.1-0.2-0.1-0.10.10.30.1-0.0-0.1
Liver weight, right2.44.09.5-0.7-3.1-3.1-3.1-0.3-2.2-2.1-2.12.01.7-1.3-0.2-0.3
Locomotor activity0.81.23.2-0.5-1.1-1.1-1.10.6-0.4-0.5-0.61.41.81.1-1.5-1.5
Locomotor testing distance0.81.33.3-1.8-1.5-1.5-1.5-0.9-1.1-1.3-1.40.10.50.3-0.5-0.6
Locomotor testing rearing3.14.710.2-3.2-2.6-2.6-2.6-2.8-2.4-2.5-2.6-1.0-0.6-1.01.11.0
Locomotion in novel chamber2.63.26.4-2.5-2.4-2.4-2.4-1.5-2.4-2.2-2.2-0.00.1-1.0-0.4-0.4
Locomotion in novel chamber post-restriction0.60.73.3-0.6-0.1-0.1-0.10.5-0.00.0-0.00.60.91.3-1.7-1.8
Fecal boli incidents, locomotor time 11.01.12.70.91.61.61.60.71.21.21.0-0.5-0.50.7-0.5-0.5
Change in fecal boli incidents, locomotor task0.20.20.40.1-0.6-0.6-0.60.0-0.4-0.4-0.40.50.6-0.30.30.3
Time >=10cm from walls, locomotor time 10.50.51.1-0.70.00.00.0-1.0-0.4-0.6-0.7-1.1-1.0-0.51.01.0
Bouts of movement, locomotor time 10.30.31.00.4-0.1-0.1-0.10.80.10.10.21.00.70.0-1.0-1.0
Total resting periods, locomotor time 10.70.81.61.00.50.50.51.30.80.90.91.10.80.5-1.1-1.1
Rest time, locomotor task time 10.80.92.60.20.50.50.50.81.11.41.50.60.61.6-1.0-0.9
Distance moved, locomotor task time 11.01.13.60.0-0.9-0.9-0.9-0.5-1.5-1.7-1.9-0.10.0-1.60.50.5
Vertical activity count, locomotor time 10.10.10.20.4-0.1-0.1-0.10.1-0.2-0.3-0.4-0.00.1-0.40.30.2
Time >=10cm from walls, locomotor time 20.40.40.9-0.9-0.9-0.9-0.9-0.3-0.2-0.5-0.40.50.70.8-0.5-0.5
Bouts of movement, locomotor time 20.50.51.5-0.8-1.2-1.2-1.2-0.7-0.5-0.3-0.40.20.2-0.30.60.5
Total resting periods, locomotor time 20.50.51.3-0.8-1.1-1.1-1.1-0.8-0.6-0.4-0.40.1-0.0-0.50.80.7
Rest time, locomotor task time 20.60.71.51.10.90.90.90.91.11.11.20.40.20.7-0.4-0.3
Distance moved, locomotor task time 20.30.30.70.5-0.5-0.5-0.50.5-0.7-0.7-0.80.80.8-0.5-0.3-0.2
Vertical activity count, locomotor time 20.10.10.20.40.30.30.30.2-0.0-0.1-0.4-0.0-0.1-0.40.20.2
Light reinforcement 11.01.95.7-2.4-1.8-1.8-1.8-1.4-1.5-1.5-1.5-0.10.30.1-0.1-0.2
Light reinforcement 20.91.22.6-0.1-1.4-1.4-1.40.6-0.6-0.7-0.81.41.60.3-1.3-1.4
Bone: marrow area2.14.69.42.81.31.31.33.12.32.32.32.42.22.1-1.9-1.9
Bone: maximum diameter0.10.20.6-0.1-0.1-0.1-0.10.40.20.20.20.70.80.7-0.8-0.7
Bone: maximum force0.81.43.20.6-0.7-0.7-0.71.31.01.01.01.81.71.4-1.3-1.4
Bone: maximum moment0.81.32.70.8-0.4-0.4-0.41.41.11.11.11.71.61.3-1.3-1.3
Mean time between licks in bursts2.33.26.21.42.42.42.41.42.52.32.3-0.2-0.02.0-0.4-0.5
Mean num. licks in bursts0.50.61.9-0.60.20.20.2-1.0-0.5-0.2-0.2-1.2-1.4-1.10.80.9
Cd content in liver0.10.10.3-0.3-0.5-0.5-0.5-0.4-0.2-0.3-0.3-0.1-0.3-0.60.20.1
Co content in liver0.70.82.10.61.21.21.2-0.30.20.20.2-1.2-1.4-1.10.80.8
Cu content in liver0.60.71.6-0.7-0.0-0.0-0.0-1.0-0.7-0.7-0.7-1.2-1.2-1.30.91.0
Fe content in liver0.40.51.91.1-0.1-0.1-0.11.20.00.00.01.41.30.0-0.5-0.6
K content in liver2.82.86.4-1.4-2.5-2.5-2.5-0.7-2.0-2.0-2.01.11.2-0.7-0.3-0.3
Mg content in liver3.53.66.3-2.0-1.8-1.8-1.8-2.1-2.5-2.5-2.5-0.8-0.7-2.01.41.4
Mn content in liver2.42.75.2-2.1-1.9-1.9-1.9-1.7-2.2-2.3-2.3-0.30.1-1.00.70.7
Na content in liver2.22.35.60.1-1.8-1.8-1.81.1-0.5-0.5-0.52.42.30.8-1.8-1.8
Rb content in liver0.60.72.3-1.5-0.5-0.5-0.5-1.3-0.8-0.9-0.9-1.1-0.9-0.50.50.5
Se content in liver4.15.09.1-2.8-2.7-2.7-2.7-2.2-3.0-3.0-3.0-0.5-0.1-1.60.30.4
Sr content in liver0.50.51.1-0.70.20.20.2-1.0-0.2-0.2-0.2-1.1-1.0-0.41.01.0
Zn content in liver1.01.13.3-1.8-0.9-0.9-0.9-1.3-1.4-1.2-1.2-0.9-0.6-0.40.00.0
Bone: minimum diameter0.40.81.60.90.30.30.31.30.91.01.01.31.10.8-0.8-0.8
Time in familiar zone, hab. session 12.01.85.90.7-1.3-1.3-1.31.3-0.1-0.3-0.32.22.41.1-1.6-1.5
Time in novel zone, hab. session 12.62.58.1-1.60.90.90.9-2.1-0.3-0.1-0.1-2.8-2.8-1.11.71.6
Total zone transitions, hab. session 10.40.62.31.51.11.11.10.70.40.40.4-0.2-0.4-0.60.30.5
Total locomotion distance, hab. session 10.30.41.1-0.1-0.2-0.2-0.2-0.5-0.8-0.8-0.8-0.6-0.5-1.10.80.8
Locomotion velocity, hab. session 10.20.20.90.4-0.2-0.2-0.2-0.0-0.6-0.6-0.60.0-0.0-1.00.50.5
Time in familiar zone, hab. session 21.71.73.7-0.2-1.7-1.7-1.70.1-1.6-1.9-1.91.21.3-0.8-0.5-0.5
Time in novel zone, hab. session 20.70.71.4-0.80.70.70.7-0.80.91.11.1-1.2-1.20.60.40.4
Total zone transitions, hab. session 20.70.92.01.41.21.21.21.11.11.01.00.1-0.00.5-0.2-0.1
Total locomotion distance, hab. session 20.40.51.01.00.70.70.71.00.90.80.80.30.30.7-0.6-0.5
Locomotion velocity, hab. session 20.50.61.41.20.80.80.81.10.90.90.90.40.30.7-0.5-0.5
Novel to familiar place preference ratio0.20.21.60.4-0.1-0.1-0.1-0.1-0.6-0.4-0.40.0-0.3-1.30.50.4
Novelty place preference0.40.42.00.20.00.00.0-0.4-0.7-0.4-0.4-0.3-0.6-1.40.90.8
Time in novel zone, NPP test0.40.52.0-0.1-0.3-0.3-0.3-0.5-1.0-0.7-0.7-0.3-0.5-1.40.80.7
Total zone transitions, NPP test1.21.83.61.90.90.90.91.91.51.21.20.91.11.6-1.3-1.2
Total locomotion distance, NPP test0.60.81.70.90.40.40.41.20.90.80.80.60.81.3-1.1-1.0
Locomotion velocity, NPP test0.71.01.81.40.90.90.91.31.21.11.10.40.51.1-0.8-0.7
Intraocular pressure2.23.17.72.32.82.82.81.01.61.61.6-1.0-1.3-0.00.10.2
Delta distance traveled before/after self-admin0.30.31.21.10.80.80.80.40.30.20.20.0-0.2-0.60.50.5
Delta ambulatory time before/after self-admin0.30.41.51.20.60.60.61.00.40.40.40.70.5-0.0-0.3-0.3
Parametrial fat weight0.81.53.0-1.4-1.7-1.7-1.7-0.3-0.8-0.8-0.80.91.10.7-1.4-1.4
Pavlov. Cond. lever latency1.01.23.41.01.21.21.2-0.20.30.40.4-0.9-1.3-1.31.81.7
Pavlov. Cond. magazine entry latency2.83.68.6-2.9-2.6-2.6-2.6-1.4-2.0-2.1-2.10.40.90.2-1.3-1.1
Pavlov. Cond. change in total contacts3.84.110.5-3.2-2.1-2.1-2.1-2.6-2.4-2.4-2.4-1.4-1.0-1.10.60.7
Pavlov. Cond. index score1.72.15.3-2.3-1.9-1.9-1.9-0.8-1.2-1.2-1.20.40.91.0-1.7-1.4
Pavlov. Cond. latency score1.41.83.3-1.8-1.7-1.7-1.7-0.4-0.9-0.9-0.90.71.11.1-1.8-1.6
Pavlov. Cond. lever contacts0.80.93.4-0.8-0.6-0.6-0.60.40.10.10.10.71.11.5-1.9-1.7
Pavlov. Cond. magazine entry number3.13.810.73.32.52.52.51.92.22.32.30.3-0.30.00.80.6
Pavlov. Cond. intertrial magazine entries0.50.61.10.81.01.01.00.00.50.30.3-0.7-0.9-0.70.80.7
Pavlov. Cond. lever-magazine prob. diff.1.72.16.5-2.6-1.9-1.9-1.9-1.1-1.3-1.3-1.30.10.70.9-1.4-1.1
Pavlov. Cond. response bias2.42.98.4-2.9-2.3-2.3-2.3-1.7-1.8-1.9-1.9-0.20.30.1-0.7-0.4
Pavlov. Cond. lever latency0.10.10.60.80.30.30.30.30.10.30.3-0.0-0.3-0.40.30.3
Pavlov. Cond. magazine entry latency0.10.10.20.40.40.40.40.30.2-0.0-0.00.20.20.2-0.3-0.3
Pavlov. Cond. change in total contacts0.30.31.3-1.10.00.00.0-1.0-0.0-0.3-0.3-1.0-0.70.30.50.5
Pavlov. Cond. index score0.10.10.3-0.20.10.10.10.10.1-0.1-0.10.10.40.6-0.4-0.4
Pavlov. Cond. latency score0.10.10.4-0.00.30.30.30.20.30.10.10.10.30.6-0.4-0.4
Pavlov. Cond. lever contacts0.30.40.7-0.8-0.6-0.6-0.6-0.1-0.2-0.4-0.40.40.80.8-0.7-0.7
Pavlov. Cond. magazine entry number0.10.10.2-0.00.00.00.0-0.10.30.50.5-0.3-0.30.00.20.2
Pavlov. Cond. intertrial magazine entries0.81.02.20.41.01.01.0-0.50.40.70.7-1.2-1.4-0.71.51.5
Pavlov. Cond. lever-magazine prob. diff.0.00.10.2-0.10.10.10.10.10.1-0.1-0.10.10.30.5-0.3-0.3
Pavlov. Cond. response bias0.40.51.0-1.0-0.8-0.8-0.8-0.3-0.6-0.8-0.80.40.70.5-0.7-0.7
Time in closed arm before self-admin0.91.02.5-0.9-0.4-0.4-0.4-1.4-0.7-1.1-1.0-1.0-0.7-0.61.61.6
Time in closed arm after self-admin1.11.14.70.50.30.30.3-0.8-0.2-0.5-0.4-1.0-0.9-1.32.22.2
Time in open arm before self-admin0.60.61.60.90.40.40.41.20.60.80.71.10.90.4-0.9-0.9
Time in open arm after self-admin0.30.30.80.50.70.70.70.40.70.90.9-0.1-0.40.3-0.3-0.3
Bone: periosteal estimation0.81.63.01.10.30.30.31.71.21.21.21.71.61.5-1.4-1.4
Bone: periosteal perimeter1.11.83.21.40.90.90.91.81.51.51.51.41.41.6-1.2-1.2
Bone: post-yield work0.81.12.41.50.90.90.91.21.51.51.50.50.40.9-0.0-0.1
Progressive ratio test 1 active lever presses0.50.51.4-0.4-0.9-0.9-0.9-0.6-1.2-1.0-0.90.0-0.2-0.60.30.3
Progressive ratio test 1 breakpoint0.50.51.4-0.3-0.9-0.9-0.9-0.6-1.2-1.0-1.00.2-0.0-0.70.30.3
Progressive ratio test 1 inactive lever presses1.51.73.1-1.4-1.7-1.7-1.7-1.4-1.8-1.5-1.4-0.1-0.3-0.90.70.7
Progressive ratio test 2 active lever presses0.40.41.3-0.9-0.5-0.5-0.5-1.1-0.6-0.5-0.4-0.9-0.9-0.10.50.5
Progressive ratio test 2 breakpoint0.30.41.0-0.9-0.5-0.5-0.5-1.0-0.6-0.4-0.3-0.8-0.8-0.20.50.5
Progressive ratio test 2 inactive lever presses0.20.30.7-0.8-0.4-0.4-0.4-0.8-0.7-0.5-0.4-0.6-0.6-0.20.30.3
Incentive Sensitization - Responses0.80.82.4-1.00.70.70.7-0.80.90.91.0-1.6-1.21.1-0.0-0.0
Incentive Sensitization - Breakpoint0.60.61.8-0.90.60.60.6-0.70.80.80.9-1.3-1.01.0-0.1-0.1
Sum of active levers in priming session hrs 5-61.41.42.5-0.5-1.6-1.6-1.60.1-1.2-1.3-1.31.51.5-0.3-0.6-0.6
Progressive ratio0.40.51.0-0.2-0.6-0.6-0.60.4-0.4-0.2-0.31.01.00.6-1.0-1.0
Food seeking constrained by brief footshock0.60.71.6-0.4-1.0-1.0-1.00.4-0.8-0.7-0.81.21.30.4-0.9-0.9
Seeking ratio, punishment vs. effort0.10.10.20.10.20.20.2-0.20.0-0.1-0.0-0.4-0.4-0.30.50.4
Retroperitoneal fat weight0.10.21.10.4-0.3-0.3-0.30.60.10.40.41.10.90.4-0.3-0.2
Reaction time number correct0.50.81.80.80.80.80.81.01.01.31.40.50.41.0-0.4-0.4
Reaction time mean minus median1.01.42.80.51.71.71.70.11.31.41.5-1.0-1.10.70.40.4
Reaction time mean minus median AUC0.70.91.70.11.31.31.3-0.20.91.01.2-1.0-1.10.50.40.4
Reaction time num false alarms0.50.72.2-0.0-0.5-0.5-0.50.60.40.20.10.91.31.5-1.3-1.2
Reaction time num false alarms AUC0.60.93.8-0.0-0.2-0.2-0.20.70.80.60.50.81.31.9-1.3-1.3
Reaction time trials correct on left0.50.81.80.80.80.80.81.01.01.31.40.50.41.0-0.4-0.4
Reaction time trials on left0.50.81.90.80.80.80.81.01.11.31.40.40.31.1-0.3-0.4
Reaction time mean0.70.91.6-0.7-0.3-0.3-0.3-1.3-1.0-1.1-1.1-1.1-1.1-1.11.21.1
Reaction time mean AUC0.71.01.7-0.7-0.4-0.4-0.4-1.3-1.1-1.1-1.1-1.0-1.1-1.21.21.1
Median of all reaction times1.31.83.5-1.2-1.0-1.0-1.0-1.7-1.7-1.8-1.9-1.0-0.9-1.41.11.1
Reaction time omissions0.20.31.1-1.0-0.7-0.7-0.7-0.7-0.6-0.7-0.7-0.20.00.1-0.1-0.1
Reaction time false alarm rate0.30.41.3-0.4-0.6-0.6-0.60.10.2-0.1-0.20.51.01.2-1.0-0.9
Reaction time premature initiation rate2.33.16.9-0.9-2.2-2.2-2.2-0.4-2.4-2.6-2.51.21.1-1.6-0.3-0.3
Reaction time premature initiations0.91.22.3-0.2-1.4-1.4-1.40.2-1.4-1.5-1.41.31.1-0.9-0.3-0.4
Std. dev. reaction times0.40.51.0-0.01.01.01.0-0.30.60.50.6-0.9-1.00.30.40.5
Reaction time trials completed0.50.81.90.80.80.80.81.01.11.31.40.40.31.1-0.3-0.4
Reaction time trials AUC0.50.71.90.70.90.90.90.81.11.31.40.20.11.0-0.2-0.2
Run reversals in cocaine runway, females1.71.66.90.60.10.10.1-0.8-0.4-0.3-0.2-0.8-1.2-2.12.62.6
Run reversals in cocaine runway, males0.40.40.9-0.6-0.4-0.4-0.4-0.5-0.9-0.9-1.0-0.4-0.4-0.80.1-0.0
Latency to leave start box in cocaine runway0.40.40.80.90.90.90.90.40.50.40.4-0.1-0.1-0.30.70.7
Latency to leave start box in cocaine runway, F0.20.20.91.00.40.40.40.70.0-0.0-0.00.50.3-0.60.10.1
Latency to leave start box in cocaine runway, M0.60.61.9-0.90.10.10.1-1.1-0.1-0.0-0.1-1.0-0.8-0.31.31.4
Std. dev. time between licks in bursts0.50.62.10.30.50.50.50.81.11.01.00.50.71.5-0.7-0.8
Total sessions with >9 infusions1.31.42.4-1.0-1.3-1.3-1.3-1.2-1.5-1.5-1.4-0.4-0.4-1.21.21.2
Short access day 1 total inactive lever presses1.11.32.4-1.3-1.4-1.4-1.4-1.3-1.6-1.3-1.2-0.5-0.7-0.60.40.4
Short access day 10 total inactive lever presses0.10.20.30.1-0.6-0.6-0.60.1-0.6-0.3-0.20.50.4-0.4-0.1-0.1
Short access day 1 total infusions2.52.75.2-0.9-2.0-2.0-2.0-1.2-2.3-2.2-2.10.2-0.0-1.61.01.0
Short access day 10 total infusions0.30.30.8-0.2-0.7-0.7-0.7-0.0-0.9-0.9-0.80.50.5-0.1-0.4-0.4
Short access total infusions1.82.14.6-0.6-1.7-1.7-1.7-1.0-2.1-2.1-2.00.2-0.0-1.50.80.8
Short access day 1 locomotion1.81.94.3-2.1-1.7-1.7-1.7-1.6-1.7-1.6-1.6-0.4-0.1-0.50.50.5
Short access day 10 total locomotion0.30.31.2-0.70.40.40.4-0.40.50.50.5-0.5-0.31.1-0.5-0.5
Short access total locomotion0.50.51.3-0.70.00.00.0-1.1-0.1-0.1-0.1-1.0-1.0-0.01.11.1
One hour access (0.3 mA shock)0.10.10.2-0.1-0.1-0.1-0.1-0.4-0.4-0.0-0.0-0.3-0.4-0.30.50.5
Compulsive drug intake2.42.46.50.01.41.41.4-1.10.71.01.0-2.3-2.5-0.42.22.2
One hour access (shock baseline)0.70.81.5-0.2-1.2-1.2-1.20.1-0.9-0.8-0.81.11.1-0.2-0.8-0.8
Social response proportion0.10.10.40.60.00.00.00.60.1-0.3-0.20.50.4-0.4-0.1-0.1
Social responses0.40.51.70.3-0.5-0.5-0.50.8-0.0-0.3-0.31.21.30.5-0.8-0.8
Social time1.52.04.11.00.60.60.61.81.61.41.41.11.11.8-2.0-2.0
Soleus weight0.92.55.91.2-0.2-0.2-0.22.21.00.90.92.32.41.9-2.3-2.1
Bone: stiffness0.71.13.40.3-1.3-1.3-1.30.90.10.10.11.81.70.4-0.8-0.9
Tibialis anterior weight0.51.97.12.70.80.80.82.31.00.90.91.81.40.2-0.9-1.1
Time to tail flick, vehicle, before self-admin1.41.53.00.31.71.71.70.11.51.31.3-1.3-1.11.10.00.0
Time to tail flick, vehicle, after self-admin0.50.61.5-0.10.60.60.60.41.01.21.20.10.11.0-0.7-0.7
Time to tail flick, test, before self-admin0.70.71.91.41.21.21.20.70.80.90.70.0-0.10.20.20.2
Time to tail flick, test, after self-admin0.70.71.40.31.21.21.20.61.11.00.9-0.4-0.11.1-0.6-0.6
Delta time to tail flick, vehicle, before/after SA1.21.23.2-0.3-0.5-0.5-0.50.90.40.70.71.61.51.3-1.8-1.8
Delta time to tail flick, test, before/after SA0.20.21.1-1.10.00.00.0-0.5-0.1-0.3-0.2-0.8-0.40.4-0.3-0.3
Tibia length1.13.18.52.90.90.90.92.91.51.41.42.31.91.0-1.7-1.4
Ambulatory time before self-admin0.00.00.10.00.30.30.3-0.00.10.20.3-0.2-0.30.00.20.2
Ambulatory time after self-admin0.70.82.61.60.90.90.91.40.60.70.81.10.70.1-0.5-0.5
Bone: tissue strength1.91.84.90.91.61.61.60.72.22.02.0-0.6-0.51.30.20.1
Total heroin consumption1.51.74.1-1.3-1.2-1.2-1.20.4-0.1-0.2-0.21.41.81.8-2.0-2.0
Bone: trabecular number2.53.910.9-2.1-3.3-3.3-3.3-0.8-1.5-1.4-1.41.21.60.6-1.2-1.3
Bone: trabecular spacing1.31.74.22.01.31.31.32.10.91.01.01.10.90.6-1.3-1.3
Bone: trabecular thickness0.10.10.6-0.2-0.2-0.2-0.2-0.10.50.50.5-0.10.10.8-0.0-0.0
Bone: trabecular tissue density1.21.74.4-0.90.60.60.6-1.6-0.4-0.3-0.3-1.9-2.1-1.41.91.9
Water consumed over 24 hours0.40.40.90.40.70.70.70.51.00.90.90.10.20.9-0.0-0.1
Number of responses in last shaping day1.51.62.3-1.4-1.1-1.1-1.1-1.5-1.4-1.4-1.4-0.9-0.9-1.21.41.4