Hub : Genes

Krt222

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Krt222 0.03 0.02 3.0e-04 0.03 0.03 0.03 0.03 3.0e-04 9.7e-05 8.6e-04 7.2e-04
2 pVTA mRNA stability Krt222 0.04 0.04 3.5e-03 0.03 0.03 0.02 0.03 3.4e-03 2.8e-03 1.7e-02 3.1e-03
3 Adipose isoform ratio XM_006247443.5 0.08 0.06 2.7e-06 0.04 0.05 0.06 0.01 1.3e-05 3.4e-06 7.1e-07 1.2e-02
4 PL mRNA stability Krt222 0.05 0.03 1.1e-04 0.04 0.03 0.03 0.04 3.8e-05 2.2e-04 2.4e-04 2.8e-05
5 OFC mRNA stability Krt222 0.26 0.15 1.6e-03 0.09 0.07 0.07 -0.01 3.5e-03 1.2e-02 9.5e-03 7.0e-01
6 LHb mRNA stability Krt222 0.3 0.15 6.4e-05 0.23 0.22 0.19 0.02 2.7e-06 6.1e-06 2.5e-05 8.9e-02
7 NAcc gene expression Krt222 0.17 0.07 0.0e+00 0.17 0.16 0.17 0.17 2.2e-24 2.7e-23 9.2e-26 3.5e-25
8 Brain mRNA stability Krt222 0.04 0.02 6.3e-04 0.04 0.02 0.01 0.02 1.5e-04 5.2e-03 1.7e-02 2.8e-03
9 Adipose gene expression Krt222 0.22 0.1 0.0e+00 0.15 0.2 0.2 0.22 1.4e-16 1.7e-21 2.9e-21 1.7e-23
10 Brain gene expression Krt222 0.1 0.06 2.5e-04 0.02 0.05 0.04 0.04 8.6e-03 2.5e-05 1.2e-04 1.0e-04
11 IC gene expression Krt222 0.19 0.12 9.0e-04 0 0.05 0.09 0.03 2.9e-01 4.4e-03 1.3e-04 1.8e-02
12 PL gene expression Krt222 0.21 0.08 8.8e-09 0.04 0.07 0.06 0.06 2.1e-05 1.6e-08 2.5e-07 3.7e-07
13 BLA gene expression Krt222 0.16 0.08 5.7e-04 0.06 0.05 0.07 0.05 3.2e-04 8.2e-04 2.2e-04 1.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density1.32.35.31.01.7-0.31.82.32.32.10.90.10.4-1.41.31.7
Area under the delay curve0.70.81.91.31.1-0.71.00.60.51.01.40.7-0.51.20.1-0.5
BMI with tail1.55.311.6-3.0-2.33.4-2.0-1.6-1.6-1.4-2.2-3.22.91.51.81.8
BMI without tail1.03.17.3-2.1-1.42.7-1.3-1.1-1.1-0.5-1.3-2.62.42.01.71.2
Body weight3.113.726.8-4.7-3.85.2-3.3-2.9-2.8-1.8-3.3-4.84.63.33.02.9
Weight adjusted by age1.01.65.6-0.10.31.40.71.11.11.2-0.0-1.41.50.71.92.4
Bone surface0.81.54.6-0.90.01.20.21.01.01.1-0.8-1.41.6-0.12.02.1
Bone volume1.12.06.2-1.00.21.50.31.21.21.3-0.8-1.62.0-0.62.32.5
Breakpoint value in progressive ratio session0.20.30.80.20.30.10.90.80.60.60.6-0.00.20.10.60.9
Number of licking bursts0.40.61.6-0.9-0.30.9-0.10.20.30.5-0.5-1.11.1-0.51.21.3
Context. condit. distance diff. score0.70.92.10.5-0.3-1.0-0.2-0.8-0.8-0.90.61.2-1.30.7-1.5-1.2
Locomotion velocity, session 10.70.83.0-0.8-0.21.1-0.2-0.3-0.30.3-0.1-1.21.31.71.20.8
Locomotion distance, session 12.12.65.9-1.9-1.22.1-1.1-1.1-1.10.1-0.9-2.12.22.41.91.1
Locomotion velocity, session 20.10.21.8-0.1-0.10.00.20.00.00.20.4-0.10.11.40.30.3
Locomotion distance, session 21.01.33.3-0.9-0.31.5-0.2-0.1-0.00.7-0.4-1.61.71.61.81.4
Locomotion velocity, session 30.20.20.60.60.3-0.70.50.20.30.20.70.7-0.70.0-0.3-0.2
Locomotion distance, session 30.10.10.3-0.5-0.50.3-0.4-0.5-0.4-0.1-0.3-0.30.20.30.30.3
Stereotopy head waving bouts, day 31.92.24.42.11.9-1.61.81.81.71.11.61.6-1.3-0.3-0.6-0.6
Stereotopy head waving duration, day 30.30.40.80.80.9-0.40.80.90.90.50.60.4-0.10.50.1-0.1
Locomotion velocity, session 71.31.43.0-1.7-1.41.5-1.3-0.8-0.8-0.5-1.6-1.41.3-0.21.01.0
Locomotion distance, session 71.01.32.9-1.4-1.70.7-1.6-1.5-1.5-1.1-1.6-0.60.3-0.3-0.1-0.2
Stereotopy head waving bouts, day 71.01.12.31.01.4-0.21.41.41.41.51.20.20.3-0.10.90.7
Stereotopy head waving duration, day 71.21.52.81.21.6-0.21.71.51.51.71.60.20.30.71.00.7
Locomotion velocity, session 82.22.76.4-1.6-2.11.2-1.8-2.3-2.2-1.9-1.0-1.10.62.5-0.4-0.2
Locomotion distance, session 80.50.73.9-0.8-0.70.9-0.5-0.8-0.7-0.1-0.1-0.80.92.00.80.6
Degree of sensitization distance1.31.32.8-1.2-1.70.5-1.6-1.6-1.6-1.5-1.5-0.4-0.0-0.1-0.7-0.5
Degree of sensitization stereotypy1.01.12.20.91.3-0.01.41.31.31.51.3-0.00.40.11.00.9
Conditioned locomotion0.40.40.70.80.8-0.80.80.80.70.80.60.7-0.5-0.5-0.00.0
Cocaine response after cond. corrected1.41.73.70.41.21.01.11.21.21.90.9-1.01.41.31.91.5
Cocaine response after cond. not corrected1.51.84.10.31.11.11.11.41.42.00.6-1.01.41.12.01.8
Cocaine response before conditioning0.10.10.4-0.1-0.4-0.3-0.20.20.2-0.3-0.60.4-0.5-0.6-0.50.3
Saline control response0.40.61.6-0.7-0.61.3-0.3-0.1-0.10.1-0.4-0.80.91.00.91.1
Bone: connectivity density1.62.56.01.31.9-0.82.02.52.42.21.20.6-0.2-1.40.91.3
Bone: cortical apparent density3.64.910.72.72.2-3.31.91.51.40.52.12.9-2.8-2.0-2.0-2.1
Bone: cortical area0.10.21.5-0.00.1-0.00.20.60.60.5-0.20.10.1-1.20.40.5
Bone: cortical porosity0.91.02.60.11.00.60.81.21.11.40.2-0.71.20.01.61.4
Bone: cortical porosity1.11.23.2-0.10.71.10.61.01.01.30.1-1.11.50.51.81.6
Bone: cortical thickness1.01.72.71.61.4-1.51.51.41.41.11.31.5-1.2-1.4-0.4-0.2
Bone: cortical thickness4.75.59.83.03.0-2.13.12.92.92.83.02.0-1.3-0.10.30.2
Bone: cortical tissue density3.54.810.42.72.2-3.21.91.41.40.52.12.8-2.8-2.0-2.0-2.1
Condit. Reinf. active minus inactive responses1.21.32.91.71.2-1.41.10.60.60.71.61.5-1.4-0.3-1.0-0.8
Condit. Reinf. active-inactive response ratio1.81.94.21.81.2-1.91.10.60.60.61.52.0-1.9-0.9-1.2-1.1
Condit. Reinf. active responses0.91.12.31.51.1-1.21.10.60.60.51.51.3-1.3-0.1-1.0-0.7
Condit. Reinf. inactive responses0.10.10.20.00.30.40.30.30.30.10.2-0.50.40.40.30.4
Incentive salience index mean0.91.12.11.51.1-1.21.00.70.70.81.31.3-1.3-1.0-0.7-0.4
Condit. Reinf. lever presses0.20.32.00.40.2-0.40.40.50.60.60.20.5-0.4-1.40.00.5
Condit. Reinf. active minus inactive responses0.20.20.50.20.5-0.30.60.70.70.70.40.1-0.0-0.60.40.4
Condit. Reinf. active-inactive response ratio0.20.20.40.00.20.00.40.60.60.60.1-0.20.2-0.60.50.7
Condit. Reinf. active responses0.40.61.40.30.8-0.10.91.11.11.20.5-0.10.3-0.70.80.7
Condit. Reinf. inactive responses0.50.61.70.51.1-0.10.91.21.21.30.5-0.10.4-0.30.80.5
Condit. Reinf. lever presses0.10.20.50.40.4-0.70.50.30.30.50.50.6-0.40.0-0.1-0.3
Condit. Reinf. lever reinforcers received0.50.71.60.61.0-0.51.01.21.21.30.70.2-0.0-0.80.60.5
Conditioned reinforcement - actives0.20.41.2-0.1-0.6-0.4-0.6-0.8-0.7-0.5-0.20.3-0.6-0.4-0.7-1.1
Conditioned reinforcement - inactives0.30.51.80.1-0.3-0.7-0.4-0.3-0.3-0.8-0.20.5-1.0-0.4-1.3-1.1
Conditioned locomotion0.10.20.7-0.2-0.2-0.2-0.4-0.8-0.5-0.0-0.1-0.1-0.2-0.6-0.1-0.8
Patch foraging indifference point 0 sec0.91.78.00.90.1-1.80.20.40.40.1-0.21.8-1.9-2.8-1.3-0.8
Patch foraging indifference point AUC0.20.30.80.00.40.20.60.70.70.70.4-0.40.60.40.90.9
Delay disc. indifference point, 0s delay0.70.81.61.01.1-1.01.01.10.91.20.70.8-0.5-1.30.2-0.2
Delay disc. indifference point, 16s delay2.52.75.92.31.8-1.71.91.31.21.12.41.7-1.32.1-0.6-0.8
Delay disc. indifference point, 2s delay0.20.21.00.20.60.10.30.30.51.00.2-0.30.4-0.50.80.2
Delay disc. indifference point, 24s delay0.30.31.50.3-0.4-0.6-0.1-0.4-0.5-0.40.30.5-0.81.2-0.7-0.7
Delay disc. indifference point, 4s delay1.51.63.11.61.7-0.61.71.41.41.81.80.5-0.21.00.70.2
Delay disc. indifference point, 8s delay0.00.00.10.10.0-0.2-0.1-0.2-0.30.20.00.2-0.2-0.2-0.1-0.3
Indifference point function ln k0.30.51.40.70.1-1.00.0-0.3-0.3-0.20.41.2-1.10.1-1.0-1.1
Indifference point function log k0.30.51.40.70.1-1.00.0-0.3-0.3-0.20.41.2-1.10.1-1.0-1.1
Patch foraging total patch changes 0 sec0.81.47.70.4-0.3-1.6-0.20.00.0-0.3-0.61.5-1.7-2.8-1.3-0.8
Patch foraging total patch changes 12 sec1.21.63.80.81.3-0.81.41.92.01.70.50.5-0.2-2.00.80.7
Patch foraging total patch changes 18 sec0.30.43.3-0.3-0.4-0.40.00.50.5-0.1-0.60.2-0.4-1.8-0.20.5
Patch foraging total patch changes 24 sec0.50.91.90.70.9-0.71.01.41.41.30.40.6-0.2-1.20.60.9
Patch foraging total patch changes 6 sec0.50.84.00.70.3-1.10.50.90.90.40.01.0-1.1-2.0-0.50.0
Patch foraging time to switch 0 sec0.00.10.30.10.30.40.30.10.20.40.3-0.30.30.50.5-0.0
Patch foraging water rate 0 sec0.10.20.80.30.1-0.80.1-0.0-0.0-0.00.20.7-0.6-0.9-0.5-0.3
Patch foraging water rate 12 sec0.00.10.20.10.2-0.40.20.20.10.40.20.4-0.2-0.20.10.0
Patch foraging water rate 18 sec0.81.33.10.40.9-0.01.21.61.71.80.50.00.6-0.01.61.7
Patch foraging water rate 24 sec0.10.20.50.30.3-0.60.30.40.40.50.10.5-0.4-0.70.0-0.0
Patch foraging water rate 6 sec1.01.52.71.31.4-1.11.61.61.61.71.50.9-0.6-0.30.3-0.0
Seeking ratio, delayed vs. immediate footshock1.41.73.91.30.5-1.90.5-0.0-0.2-0.61.21.9-1.90.2-2.0-1.9
Distance traveled before self-admin0.50.71.40.40.60.51.00.81.10.90.7-0.50.60.81.01.2
Distance traveled after self-admin0.20.21.2-0.2-0.10.50.0-0.2-0.2-0.20.1-0.50.51.10.30.5
Extensor digitorum longus weight3.814.929.1-4.5-5.42.9-5.0-5.4-5.3-4.9-3.8-2.31.42.3-1.1-0.7
Bone: elastic displacement0.60.71.4-0.5-0.8-0.0-1.0-1.1-1.2-1.2-0.80.1-0.4-0.7-0.9-1.1
Bone: elastic work0.20.30.80.10.60.40.50.60.60.80.3-0.40.60.30.90.4
Bone: endosteal estimation2.35.09.7-3.0-2.13.1-2.0-1.4-1.3-0.8-2.5-3.02.91.12.11.9
Bone: endosteal perimeter1.32.75.9-2.4-2.01.9-1.9-1.5-1.5-1.3-2.1-1.91.60.10.80.7
Epididymis fat weight0.20.61.8-0.8-0.41.2-0.2-0.1-0.10.4-0.3-1.11.30.41.31.1
Delta time in closed arm before/after self-admin1.21.12.4-1.3-1.01.4-0.8-0.4-0.7-0.7-1.1-1.31.31.60.60.9
Delta time in open arm before/after self-admin0.20.20.50.70.5-0.30.50.10.3-0.20.60.4-0.30.7-0.5-0.0
Diff in mean of infusions in LGA sessions0.20.20.70.00.30.20.30.50.60.70.1-0.10.4-0.80.50.8
Delay discount exponential model param0.60.71.8-1.2-1.00.7-0.9-0.4-0.4-0.9-1.4-0.70.5-1.3-0.00.5
Extinction: sum of active levers before priming0.70.81.7-1.2-1.11.1-0.6-0.3-0.4-0.4-0.9-1.11.10.50.71.3
Active lever presses in extinction session 64.34.311.60.21.41.81.71.92.12.71.1-1.72.50.83.43.1
Bone: final force1.01.74.8-0.30.70.90.71.51.51.8-0.2-1.01.5-0.62.21.9
Bone: final moment0.91.54.4-0.40.51.00.61.31.31.6-0.3-1.11.6-0.62.11.8
Food consumed during 24 hour testing period0.40.50.9-0.9-0.90.8-1.0-0.9-0.9-0.6-0.9-0.60.50.50.10.1
Glucose0.50.82.6-0.70.20.80.00.60.60.8-0.7-1.01.4-0.11.61.4
Heart weight1.52.34.7-2.0-2.21.4-1.9-1.8-1.8-1.8-1.9-1.10.90.70.10.6
Delay discount hyperbolic model param0.50.51.4-1.1-0.80.5-0.7-0.3-0.3-0.8-1.2-0.60.5-1.1-0.00.5
Intermittent access intake day 1-15 change0.40.72.10.81.4-0.31.11.41.21.00.90.10.20.30.40.3
Intermittent access intake escalation0.30.71.90.81.4-0.41.11.31.10.90.80.10.10.40.30.2
Intermittent access intake escalation 20.10.10.3-0.30.20.40.10.1-0.0-0.10.0-0.60.60.50.30.1
Intermitt. access day 1 inactive lever presses0.83.06.02.12.3-1.32.32.52.42.11.81.2-0.60.10.50.6
Intermitt. access day 15 inactive lever presses0.81.73.71.51.1-1.90.60.80.50.40.71.8-1.7-1.3-1.5-1.6
Intermitt. access escalation Index0.71.03.5-0.40.11.10.40.40.60.70.2-0.91.41.91.61.5
Intermittent access day 1 total infusions0.10.10.20.3-0.1-0.3-0.1-0.50.0-0.20.20.3-0.50.4-0.4-0.3
Intermittent access day 15 total infusions0.50.81.71.11.3-0.71.00.81.10.71.10.6-0.41.1-0.1-0.1
Intermittent access terminal intake (last 3 days)0.50.61.31.11.2-0.80.90.50.80.61.10.5-0.50.9-0.2-0.4
Intermittent access total infusions0.40.51.30.90.8-0.70.70.30.70.41.00.6-0.61.1-0.4-0.3
Intermittent access day 1 locomotion0.20.30.8-0.2-0.4-0.3-0.6-0.9-0.5-0.6-0.40.2-0.4-0.4-0.6-0.9
Intermittent access day 15 total locomotion0.10.10.5-0.3-0.00.1-0.5-0.7-0.7-0.2-0.2-0.50.2-0.20.0-0.5
Intermittent access total locomotion0.30.30.80.60.6-0.80.40.20.20.10.70.5-0.7-0.1-0.6-0.9
Intermittent access standard deviation0.71.53.01.61.7-1.41.41.31.30.81.41.1-1.0-0.3-0.7-0.6
Left kidney weight0.20.93.60.00.40.70.70.40.40.91.1-0.40.91.91.31.2
Right kidney weight0.52.15.40.01.01.11.11.31.31.90.8-1.21.71.32.32.1
Cocaine induced anxiety0.91.35.5-0.7-0.71.6-0.5-0.8-0.6-0.1-0.1-1.31.32.41.11.2
Post-drug Anxiety0.20.21.50.1-0.30.40.0-0.0-0.2-0.20.4-0.1-0.01.2-0.20.8
Baseline Anxiety0.70.93.90.60.2-1.20.20.70.3-0.3-0.00.9-1.3-2.0-1.4-0.5
Tail length0.10.54.1-0.3-0.50.4-0.4-0.9-0.8-0.10.2-0.30.32.00.2-0.3
Length with tail0.73.15.3-2.1-1.92.3-1.5-1.5-1.4-0.5-1.3-2.02.02.31.61.4
Length without tail1.44.69.2-3.0-2.82.6-2.4-1.9-1.8-1.5-2.7-2.32.10.51.31.6
Times rat made contact with spout0.10.11.3-0.2-0.00.1-0.10.00.0-0.2-0.4-0.20.1-1.1-0.10.0
Lifetime Intake0.60.81.61.31.0-1.00.90.50.90.61.20.9-0.81.1-0.5-0.4
Liver weight, left0.40.71.2-1.1-1.01.1-0.6-0.4-0.3-0.2-0.7-1.11.00.81.01.1
Liver weight, right1.52.64.91.72.1-0.52.01.61.62.22.20.40.22.11.20.8
Locomotor activity0.71.13.9-0.00.90.40.90.91.01.70.7-0.81.20.42.01.2
Locomotor testing distance0.81.43.61.21.6-0.91.61.41.51.91.50.6-0.2-0.50.80.4
Locomotor testing rearing2.44.97.92.82.7-2.72.62.22.22.32.72.4-1.9-1.1-0.4-0.8
Locomotion in novel chamber1.92.45.32.12.0-1.12.22.32.01.71.81.0-0.8-0.60.10.4
Locomotion in novel chamber post-restriction0.10.20.6-0.30.20.80.40.40.10.20.2-0.70.7-0.30.70.3
Fecal boli incidents, locomotor time 10.60.91.9-1.1-1.10.8-1.3-1.0-1.3-1.4-1.3-0.80.3-0.2-0.6-0.3
Change in fecal boli incidents, locomotor task0.30.31.00.40.7-0.20.3-0.10.31.00.80.20.20.80.8-0.1
Time >=10cm from walls, locomotor time 10.50.61.40.60.1-0.90.4-0.2-0.2-0.10.81.1-1.2-0.9-1.0-1.1
Bouts of movement, locomotor time 10.30.41.1-0.4-0.21.00.10.10.2-0.0-0.0-0.70.70.80.61.1
Total resting periods, locomotor time 10.70.71.7-1.0-0.81.3-0.5-0.5-0.4-0.4-0.7-1.21.10.80.71.0
Rest time, locomotor task time 10.50.62.3-1.1-0.81.0-0.8-0.1-0.2-0.5-1.5-0.80.7-0.50.50.4
Distance moved, locomotor task time 10.50.82.61.21.0-0.51.10.70.60.81.60.5-0.31.2-0.00.1
Vertical activity count, locomotor time 10.10.10.8-0.1-0.10.1-0.3-0.6-0.4-0.00.1-0.10.10.90.0-0.4
Time >=10cm from walls, locomotor time 20.30.41.70.20.6-0.20.50.30.61.10.40.20.1-1.30.80.3
Bouts of movement, locomotor time 20.40.72.00.70.6-0.90.90.91.10.90.71.0-0.7-1.40.20.2
Total resting periods, locomotor time 20.40.61.60.80.5-0.80.80.91.00.70.71.0-0.7-1.30.00.2
Rest time, locomotor task time 20.40.51.0-1.0-1.00.9-0.8-0.6-0.6-0.7-0.9-0.80.60.40.20.0
Distance moved, locomotor task time 20.30.41.80.10.40.60.40.30.20.60.5-0.50.71.30.80.8
Vertical activity count, locomotor time 20.20.21.3-0.2-0.30.4-0.5-0.8-0.7-0.4-0.2-0.20.11.2-0.1-0.1
Light reinforcement 10.82.03.91.51.7-1.21.82.01.91.81.31.1-0.7-1.20.40.6
Light reinforcement 20.71.02.50.31.00.51.00.80.91.61.0-0.71.11.11.61.0
Bone: marrow area2.14.69.0-2.9-2.03.0-2.0-1.3-1.3-0.8-2.4-2.92.81.12.01.8
Bone: maximum diameter0.20.41.1-0.4-0.00.70.00.50.50.5-0.5-0.70.7-0.60.91.1
Bone: maximum force0.61.13.5-0.9-0.11.10.00.70.81.0-0.8-1.21.5-0.21.91.7
Bone: maximum moment0.61.12.9-1.0-0.21.2-0.20.50.50.8-0.9-1.21.5-0.21.71.6
Mean time between licks in bursts1.22.95.8-2.4-2.31.3-2.2-1.8-1.8-1.9-2.4-1.30.9-1.1-0.00.1
Mean num. licks in bursts0.40.51.60.90.4-0.80.1-0.1-0.2-0.50.40.9-1.0-0.2-1.3-1.2
Cd content in liver1.31.53.6-1.0-1.40.8-1.6-1.6-1.6-1.9-1.4-0.70.20.1-0.9-0.7
Co content in liver1.61.85.0-0.6-1.4-0.0-1.6-1.9-1.9-2.2-1.20.1-0.7-0.3-1.8-1.3
Cu content in liver0.60.71.61.10.4-0.90.50.20.2-0.20.71.2-1.2-0.9-1.3-0.5
Fe content in liver1.21.53.5-1.2-1.01.8-0.9-0.8-0.8-0.2-0.8-1.51.41.91.21.3
K content in liver3.23.15.81.92.3-0.92.42.42.42.22.11.0-0.30.30.81.1
Mg content in liver3.03.05.52.42.2-2.02.21.81.81.22.32.0-1.6-0.0-0.8-0.4
Mn content in liver1.71.94.01.61.6-2.01.51.21.11.01.71.8-1.4-0.5-0.6-0.6
Na content in liver2.72.96.50.01.41.21.42.02.02.10.6-1.31.90.72.52.5
Rb content in liver0.70.82.11.00.4-1.10.50.50.50.10.31.3-1.4-1.5-1.2-0.8
Se content in liver5.76.812.43.43.5-2.53.53.23.22.63.42.1-1.6-0.0-0.2-0.3
Sr content in liver1.00.82.50.5-0.0-1.6-0.1-0.4-0.4-0.70.21.3-1.3-0.6-1.3-1.3
Zn content in liver2.73.06.22.52.3-1.62.32.02.01.42.21.4-1.3-0.6-0.5-0.2
Bone: minimum diameter0.50.91.8-1.2-0.71.3-0.6-0.2-0.2-0.0-1.0-1.21.30.01.11.2
Time in familiar zone, hab. session 11.91.85.4-0.40.61.40.60.80.81.70.3-1.41.91.62.31.6
Time in novel zone, hab. session 12.62.67.31.10.1-2.0-0.1-0.3-0.3-1.40.11.9-2.4-2.1-2.7-2.2
Total zone transitions, hab. session 10.71.03.0-0.6-1.10.5-1.2-1.6-1.5-1.0-0.5-0.50.21.7-0.4-0.6
Total locomotion distance, hab. session 10.30.41.00.80.3-0.70.2-0.3-0.3-0.00.70.7-0.71.0-0.6-0.9
Locomotion velocity, hab. session 10.20.22.00.40.2-0.20.1-0.3-0.30.10.60.3-0.21.4-0.1-0.4
Time in familiar zone, hab. session 22.02.14.91.01.70.21.81.51.51.81.9-0.30.72.21.40.8
Time in novel zone, hab. session 21.11.17.1-0.1-0.6-0.8-0.8-0.5-0.5-0.9-1.20.7-1.0-2.7-1.2-0.6
Total zone transitions, hab. session 20.91.22.4-1.3-1.30.9-1.4-1.6-1.5-0.9-1.0-1.00.71.10.1-0.3
Total locomotion distance, hab. session 20.50.71.1-0.9-0.80.9-1.0-1.0-1.0-0.5-0.9-0.90.70.80.2-0.2
Locomotion velocity, hab. session 20.60.81.2-1.0-0.90.9-1.1-1.1-1.1-0.6-1.0-0.90.70.90.2-0.1
Novel to familiar place preference ratio0.10.10.70.40.0-0.10.2-0.1-0.0-0.00.40.4-0.30.9-0.20.0
Novelty place preference0.20.20.50.50.0-0.40.1-0.2-0.1-0.20.40.7-0.70.6-0.5-0.3
Time in novel zone, NPP test0.20.30.60.80.4-0.60.40.20.20.10.70.8-0.70.5-0.4-0.2
Total zone transitions, NPP test1.42.03.6-1.9-1.61.7-1.5-1.5-1.4-0.5-1.3-1.81.51.41.10.7
Total locomotion distance, NPP test0.50.81.2-1.1-0.81.0-0.9-0.9-0.9-0.2-0.9-1.11.00.80.80.3
Locomotion velocity, NPP test0.91.22.1-1.4-1.31.1-1.4-1.4-1.4-0.7-1.1-1.10.91.10.40.0
Intraocular pressure3.14.49.6-1.7-2.71.3-2.6-3.1-3.0-3.1-1.7-1.20.01.7-1.5-1.0
Delta distance traveled before/after self-admin0.40.41.2-0.4-0.50.0-0.7-0.9-1.0-1.0-0.2-0.10.01.1-0.5-0.6
Delta ambulatory time before/after self-admin0.60.72.4-0.9-0.60.9-0.8-0.8-1.0-0.7-0.4-0.90.91.60.40.1
Parametrial fat weight0.30.82.10.20.80.80.50.80.81.40.1-0.71.0-0.51.51.1
Pavlov. Cond. lever latency0.70.92.7-0.2-0.6-0.6-0.7-1.1-1.1-1.5-0.10.5-0.80.7-1.3-1.6
Pavlov. Cond. magazine entry latency3.54.59.42.12.8-1.02.73.13.13.02.00.7-0.1-1.51.11.2
Pavlov. Cond. change in total contacts4.54.88.83.02.5-2.42.62.32.42.02.42.4-2.0-1.7-0.8-0.4
Pavlov. Cond. index score2.12.65.51.51.9-0.62.02.32.42.31.30.4-0.0-1.61.01.3
Pavlov. Cond. latency score1.72.14.81.11.6-0.21.72.12.22.20.90.10.3-1.41.21.6
Pavlov. Cond. lever contacts0.70.82.20.20.60.40.71.11.21.40.2-0.50.7-1.01.21.5
Pavlov. Cond. magazine entry number4.25.29.1-2.7-3.01.8-3.0-3.0-3.0-2.8-2.5-1.61.11.8-0.3-0.5
Pavlov. Cond. intertrial magazine entries0.60.82.1-0.4-0.90.1-0.9-1.2-1.2-1.4-0.40.0-0.41.0-1.0-0.9
Pavlov. Cond. lever-magazine prob. diff.2.43.06.31.72.2-0.92.22.52.52.51.50.7-0.3-1.80.81.1
Pavlov. Cond. response bias3.44.27.72.32.6-1.52.62.72.82.82.11.3-0.8-1.70.70.9
Pavlov. Cond. lever latency0.10.20.6-0.2-0.60.2-0.4-0.5-0.5-0.7-0.2-0.0-0.20.2-0.6-0.0
Pavlov. Cond. magazine entry latency0.10.10.4-0.3-0.20.3-0.3-0.3-0.3-0.3-0.2-0.50.30.70.2-0.0
Pavlov. Cond. change in total contacts0.30.41.70.30.3-1.10.10.10.0-0.10.10.7-0.8-0.7-0.7-1.3
Pavlov. Cond. index score0.00.00.1-0.30.10.0-0.1-0.1-0.10.1-0.1-0.30.30.20.3-0.2
Pavlov. Cond. latency score0.00.10.1-0.3-0.00.0-0.2-0.2-0.2-0.0-0.3-0.40.30.30.3-0.3
Pavlov. Cond. lever contacts0.10.20.60.00.40.00.30.50.50.80.1-0.20.3-0.10.70.2
Pavlov. Cond. magazine entry number0.10.10.4-0.1-0.40.0-0.3-0.2-0.2-0.3-0.40.2-0.2-0.6-0.30.1
Pavlov. Cond. intertrial magazine entries0.71.12.3-0.2-1.3-0.7-1.0-1.4-1.3-1.3-0.50.9-1.2-0.0-1.5-1.0
Pavlov. Cond. lever-magazine prob. diff.0.00.00.1-0.30.00.0-0.2-0.2-0.20.0-0.2-0.30.30.30.3-0.3
Pavlov. Cond. response bias0.30.40.90.40.9-0.20.70.80.81.00.6-0.00.2-0.20.70.2
Time in closed arm before self-admin1.21.53.41.51.2-1.90.80.40.60.81.31.6-1.50.0-0.8-1.7
Time in closed arm after self-admin0.60.62.10.70.6-1.40.50.50.40.30.61.1-0.90.8-0.6-0.7
Time in open arm before self-admin0.60.71.6-1.0-0.61.2-0.3-0.0-0.40.1-0.3-0.91.20.41.31.0
Time in open arm after self-admin0.10.10.4-0.3-0.40.3-0.2-0.3-0.4-0.6-0.1-0.20.20.0-0.10.2
Bone: periosteal estimation0.71.63.4-1.5-0.81.8-0.7-0.1-0.00.2-1.4-1.71.8-0.01.71.7
Bone: periosteal perimeter1.11.93.8-1.9-1.31.9-1.2-0.8-0.7-0.4-1.6-1.81.8-0.01.41.3
Bone: post-yield work0.60.92.1-1.4-1.40.8-1.2-1.0-0.9-0.6-1.4-0.70.6-0.10.40.2
Progressive ratio test 1 active lever presses0.20.20.70.60.5-0.30.50.10.50.40.60.2-0.20.90.1-0.1
Progressive ratio test 1 breakpoint0.10.10.60.50.4-0.30.3-0.00.40.30.50.2-0.20.8-0.0-0.2
Progressive ratio test 1 inactive lever presses0.40.61.11.10.8-0.90.91.01.00.70.90.9-0.70.3-0.2-0.0
Progressive ratio test 2 active lever presses0.20.30.50.70.5-0.70.50.40.60.30.40.5-0.7-0.4-0.5-0.4
Progressive ratio test 2 breakpoint0.20.30.60.70.6-0.70.50.50.60.40.50.4-0.6-0.4-0.4-0.3
Progressive ratio test 2 inactive lever presses0.10.10.50.40.2-0.5-0.0-0.30.0-0.10.20.4-0.50.0-0.6-0.7
Incentive Sensitization - Responses0.30.43.30.1-0.1-0.5-0.3-0.1-0.2-0.2-0.50.2-0.6-1.8-0.7-0.6
Incentive Sensitization - Breakpoint0.20.32.60.1-0.0-0.4-0.2-0.0-0.1-0.1-0.40.1-0.5-1.6-0.6-0.5
Sum of active levers in priming session hrs 5-61.31.22.20.51.10.61.11.31.21.41.0-0.40.91.01.51.4
Progressive ratio0.40.61.20.10.60.20.81.00.91.00.7-0.30.60.91.10.8
Food seeking constrained by brief footshock0.50.61.50.30.90.30.60.71.01.20.8-0.10.70.51.20.4
Seeking ratio, punishment vs. effort0.10.10.50.1-0.1-0.0-0.3-0.6-0.4-0.3-0.00.2-0.3-0.2-0.4-0.7
Retroperitoneal fat weight0.00.10.30.20.20.00.10.00.10.50.20.10.1-0.00.50.2
Reaction time number correct0.40.82.0-1.4-1.21.0-1.0-0.5-0.5-0.6-1.4-0.80.8-0.10.60.6
Reaction time mean minus median0.61.43.2-1.0-1.40.3-1.6-1.4-1.4-1.8-1.6-0.3-0.2-0.7-1.2-1.2
Reaction time mean minus median AUC0.30.71.6-0.5-0.8-0.1-1.0-0.8-0.8-1.3-1.2-0.1-0.3-0.9-1.0-0.8
Reaction time num false alarms0.50.72.0-0.60.20.80.50.80.80.90.1-0.91.10.41.41.4
Reaction time num false alarms AUC0.40.62.0-0.9-0.10.90.00.40.40.7-0.4-1.01.1-0.11.41.2
Reaction time trials correct on left0.40.82.0-1.4-1.21.0-1.0-0.5-0.5-0.6-1.4-0.80.8-0.10.60.6
Reaction time trials on left0.40.82.0-1.4-1.21.0-1.0-0.5-0.5-0.6-1.4-0.80.8-0.10.60.6
Reaction time mean0.50.91.81.20.9-1.10.70.40.40.01.01.1-1.20.1-1.2-1.4
Reaction time mean AUC0.60.91.81.41.0-1.10.90.60.60.11.01.1-1.2-0.0-1.2-1.1
Median of all reaction times1.31.93.81.91.7-1.41.61.21.20.81.81.4-1.40.1-1.0-1.2
Reaction time omissions0.20.30.50.60.6-0.70.60.70.70.30.50.5-0.5-0.2-0.3-0.1
Reaction time false alarm rate0.30.41.0-0.10.60.30.60.80.81.00.4-0.50.6-0.11.00.9
Reaction time premature initiation rate2.12.96.11.72.2-0.22.42.02.12.12.50.30.31.71.10.9
Reaction time premature initiations0.71.22.40.71.10.31.41.31.41.31.3-0.10.61.51.11.0
Std. dev. reaction times0.20.30.9-0.2-0.3-0.1-0.5-0.4-0.4-1.0-0.6-0.0-0.3-0.5-0.9-0.9
Reaction time trials completed0.40.82.0-1.4-1.21.0-1.0-0.5-0.5-0.6-1.4-0.80.8-0.10.60.6
Reaction time trials AUC0.40.72.1-1.4-1.20.8-1.1-0.6-0.6-0.8-1.5-0.60.6-0.30.40.4
Run reversals in cocaine runway, females0.50.51.60.8-0.1-0.50.0-0.4-0.2-0.30.51.0-1.01.3-0.9-0.1
Run reversals in cocaine runway, males0.10.10.40.70.4-0.10.30.30.2-0.00.60.3-0.40.3-0.4-0.2
Latency to leave start box in cocaine runway0.50.51.5-0.8-0.90.2-0.9-1.2-1.0-1.1-0.70.0-0.0-0.0-0.4-0.5
Latency to leave start box in cocaine runway, F0.30.30.6-0.6-0.80.6-0.6-0.6-0.4-0.8-0.4-0.30.30.8-0.10.3
Latency to leave start box in cocaine runway, M0.50.41.20.0-0.0-0.8-0.3-0.7-0.7-0.3-0.10.8-0.7-1.1-0.6-1.1
Std. dev. time between licks in bursts0.40.51.3-1.1-0.70.6-0.7-0.2-0.2-0.2-1.1-0.80.8-1.00.60.5
Total sessions with >9 infusions1.01.32.71.40.9-1.70.90.50.90.41.31.6-1.41.0-0.9-0.9
Short access day 1 total inactive lever presses0.71.02.31.51.1-1.30.90.61.00.61.01.1-1.2-0.0-0.8-0.8
Short access day 10 total inactive lever presses0.10.20.70.0-0.4-0.3-0.3-0.1-0.2-0.5-0.30.5-0.6-0.7-0.8-0.3
Short access day 1 total infusions1.82.44.52.11.7-1.61.81.21.71.32.11.6-1.21.8-0.3-0.3
Short access day 10 total infusions0.40.51.00.90.9-0.70.90.70.90.61.00.6-0.50.7-0.1-0.3
Short access total infusions1.21.53.21.61.4-1.11.51.01.51.11.81.1-0.81.4-0.1-0.0
Short access day 1 locomotion1.21.42.61.61.4-1.51.41.11.21.41.51.4-0.90.50.0-0.3
Short access day 10 total locomotion0.10.31.40.10.5-0.5-0.1-0.4-0.40.10.0-0.0-0.2-1.2-0.2-1.2
Short access total locomotion0.10.20.70.30.2-0.8-0.1-0.3-0.10.00.10.5-0.5-0.2-0.4-0.9
One hour access (0.3 mA shock)0.10.10.6-0.1-0.3-0.1-0.5-0.8-0.3-0.5-0.30.2-0.3-0.0-0.4-0.4
Compulsive drug intake1.41.65.40.6-0.3-1.8-0.3-0.2-0.2-1.10.22.0-2.1-0.6-2.3-1.4
One hour access (shock baseline)0.20.30.60.40.70.30.50.20.60.80.5-0.30.50.80.80.5
Social response proportion0.10.21.3-0.1-0.20.5-0.1-0.4-0.30.10.2-0.20.31.10.30.1
Social responses0.40.51.5-0.30.10.80.1-0.1-0.00.80.2-0.81.01.11.20.4
Social time1.01.44.1-1.4-0.92.0-1.0-0.5-0.5-0.2-1.5-1.71.6-0.31.11.1
Soleus weight0.82.45.7-1.7-0.52.2-0.40.20.20.7-1.1-2.22.41.02.42.1
Bone: stiffness0.71.23.20.00.70.70.81.21.31.60.2-0.61.20.31.81.7
Tibialis anterior weight0.72.36.0-1.6-1.42.3-1.1-1.1-1.0-0.7-0.8-1.91.82.41.11.3
Time to tail flick, vehicle, before self-admin1.41.53.4-1.2-1.50.4-1.6-1.8-1.5-1.4-1.3-0.70.0-1.4-0.7-0.9
Time to tail flick, vehicle, after self-admin0.60.82.7-0.8-0.80.8-0.9-0.3-0.00.0-1.4-0.90.7-1.70.51.1
Time to tail flick, test, before self-admin0.50.61.6-0.7-0.60.8-0.6-0.9-0.8-0.4-0.3-1.00.71.20.40.0
Time to tail flick, test, after self-admin0.70.81.5-1.2-0.90.8-0.9-0.7-1.0-0.6-1.1-1.10.8-1.00.40.2
Delta time to tail flick, vehicle, before/after SA1.21.23.4-0.40.31.20.11.00.81.0-0.8-1.21.3-1.11.51.9
Delta time to tail flick, test, before/after SA0.30.32.40.30.3-0.60.20.40.10.20.10.5-0.5-1.6-0.3-0.4
Tibia length1.23.27.3-2.1-1.52.7-1.2-0.9-0.8-0.4-1.4-2.52.51.81.82.0
Ambulatory time before self-admin0.10.10.30.40.2-0.10.40.10.50.30.30.0-0.00.10.10.5
Ambulatory time after self-admin0.80.94.0-0.7-0.51.2-0.4-0.6-0.4-0.3-0.2-1.21.32.00.90.9
Bone: tissue strength1.61.63.6-1.6-1.90.4-1.8-1.5-1.5-1.6-1.9-0.40.0-1.0-0.6-0.3
Total heroin consumption1.51.74.10.21.10.61.31.51.61.90.9-0.81.2-0.82.01.6
Bone: trabecular number2.64.39.51.52.6-0.42.43.13.03.11.40.20.5-1.61.82.0
Bone: trabecular spacing1.52.04.0-1.6-1.42.0-1.4-1.6-1.5-0.8-1.0-1.71.61.50.80.5
Bone: trabecular thickness0.10.21.1-0.5-0.10.2-0.10.30.20.1-0.4-0.30.3-1.10.30.4
Bone: trabecular tissue density1.11.64.01.0-0.0-1.8-0.1-0.5-0.5-0.80.31.9-2.0-0.4-1.9-1.8
Water consumed over 24 hours0.50.61.5-1.2-0.90.8-1.1-0.9-0.9-0.6-1.2-0.60.5-0.40.20.2
Number of responses in last shaping day1.01.12.80.80.6-1.60.20.00.3-0.40.61.5-1.4-0.3-1.6-1.7