Hub : Genes

Krt20

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Krt20	0.03	0.01	1.3e-05	0.03	0.03	0.03	0.03	1.7e-05	1.2e-05	9.3e-06	3.1e-05
2	pVTA	gene expression	Krt20	0.04	0.03	1.6e-04	0.04	0.05	0.03	0.04	2.5e-04	1.2e-04	1.4e-03	5.2e-04
3	Brain	gene expression	Krt20	0.07	0.04	1.1e-06	0.05	0.06	0.05	0.05	2.0e-05	6.7e-06	2.9e-05	2.2e-05
4	Liver	gene expression	Krt20	0.2	0.09	0.0e+00	0.21	0.2	0.21	0.22	4.2e-23	7.5e-22	8.7e-23	1.7e-23

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.9	1.6	3.4	-1.8	1.1	1.2	0.8
Area under the delay curve	1.2	1.9	2.3	-1.0	1.5	1.4	1.5
BMI with tail	1.7	5.8	6.5	2.4	-2.5	-2.3	-2.3
BMI without tail	0.5	2.5	2.8	1.7	-1.7	-1.5	-1.5
Body weight	2.9	12.8	15.7	4.0	-3.6	-3.4	-3.4
Weight adjusted by age	0.1	0.2	0.3	-0.4	0.6	0.5	-0.3
Bone surface	0.2	0.3	0.7	0.0	-0.7	-0.4	-0.8
Bone volume	0.2	0.4	0.8	-0.2	-0.8	-0.4	-0.9
Breakpoint value in progressive ratio session	0.2	0.3	0.4	-0.6	0.5	0.6	0.4
Number of licking bursts	0.1	0.3	0.6	0.2	-0.8	-0.5	-0.5
Context. condit. distance diff. score	0.3	0.3	0.7	0.2	0.6	0.5	0.8
Locomotion velocity, session 1	0.1	0.2	0.4	0.4	-0.6	-0.3	-0.1
Locomotion distance, session 1	1.2	1.5	2.1	1.4	-1.4	-1.1	-1.0
Locomotion velocity, session 2	0.1	0.1	0.2	0.0	0.1	0.2	0.5
Locomotion distance, session 2	0.1	0.2	0.2	0.4	-0.5	-0.4	-0.4
Locomotion velocity, session 3	0.4	0.4	0.7	-0.4	0.7	0.7	0.8
Locomotion distance, session 3	0.1	0.1	0.2	0.5	-0.2	-0.2	-0.1
Stereotopy head waving bouts, day 3	2.7	3.2	4.0	-2.0	1.8	1.8	1.6
Stereotopy head waving duration, day 3	0.3	0.4	0.7	-0.8	0.7	0.7	0.3
Locomotion velocity, session 7	2.3	2.5	3.1	1.3	-1.6	-1.6	-1.8
Locomotion distance, session 7	1.9	2.4	2.8	1.6	-1.4	-1.7	-1.6
Stereotopy head waving bouts, day 7	1.4	1.7	2.0	-1.4	1.2	1.4	1.2
Stereotopy head waving duration, day 7	1.9	2.4	2.9	-1.5	1.5	1.7	1.5
Locomotion velocity, session 8	1.7	2.1	4.6	2.2	-1.3	-1.3	-0.6
Locomotion distance, session 8	0.1	0.1	0.5	0.7	-0.2	-0.1	0.1
Degree of sensitization distance	2.1	2.3	2.6	1.6	-1.3	-1.6	-1.5
Degree of sensitization stereotypy	1.5	1.7	1.9	-1.3	1.2	1.4	1.3
Conditioned locomotion	0.7	0.8	0.9	-1.0	0.8	0.9	0.8
Cocaine response after cond. corrected	0.6	0.9	1.1	-1.0	0.9	1.1	0.9
Cocaine response after cond. not corrected	0.4	0.6	0.9	-1.0	0.7	0.8	0.4
Cocaine response before conditioning	0.3	0.3	0.9	0.2	-0.3	-0.5	-0.9
Saline control response	0.1	0.2	0.3	0.5	-0.2	-0.3	-0.6
Bone: connectivity density	1.4	2.2	4.0	-2.0	1.3	1.4	1.0
Bone: cortical apparent density	2.7	4.2	5.3	-2.2	1.9	1.8	2.3
Bone: cortical area	0.0	0.0	0.1	-0.3	-0.1	-0.0	-0.2
Bone: cortical porosity	0.3	0.3	0.8	-0.9	0.4	0.7	0.0
Bone: cortical porosity	0.2	0.2	0.4	-0.6	0.3	0.5	-0.2
Bone: cortical thickness	1.4	2.3	2.4	-1.6	1.5	1.5	1.4
Bone: cortical thickness	7.8	9.5	9.7	-3.1	3.1	3.1	3.0
Bone: cortical tissue density	2.6	4.1	5.2	-2.1	1.9	1.8	2.3
Condit. Reinf. active minus inactive responses	2.2	2.5	3.7	-1.3	1.6	1.5	1.9
Condit. Reinf. active-inactive response ratio	2.5	2.7	3.6	-1.3	1.7	1.6	1.9
Condit. Reinf. active responses	1.6	2.0	3.0	-1.2	1.4	1.3	1.7
Condit. Reinf. inactive responses	0.0	0.0	0.1	-0.3	0.1	0.1	0.2
Incentive salience index mean	1.4	1.8	2.2	-1.3	1.4	1.3	1.5
Condit. Reinf. lever presses	0.1	0.2	0.4	-0.6	0.4	0.3	0.1
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	-0.5	0.1	0.2	0.2
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	-0.3	0.1	-0.1	-0.1
Condit. Reinf. active responses	0.2	0.2	0.7	-0.8	0.2	0.4	0.3
Condit. Reinf. inactive responses	0.3	0.5	1.1	-1.1	0.4	0.7	0.5
Condit. Reinf. lever presses	0.2	0.3	0.4	-0.5	0.4	0.6	0.6
Condit. Reinf. lever reinforcers received	0.4	0.5	1.1	-1.0	0.5	0.7	0.6
Conditioned reinforcement - actives	0.0	0.2	0.2	0.4	-0.3	-0.5	-0.5
Conditioned reinforcement - inactives	0.1	0.2	0.3	0.4	-0.3	-0.6	-0.4
Conditioned locomotion	0.0	0.0	0.1	0.2	-0.3	-0.3	-0.1
Patch foraging indifference point 0 sec	0.0	0.1	0.2	-0.5	0.5	0.1	-0.1
Patch foraging indifference point AUC	0.0	0.1	0.2	-0.3	0.3	0.5	0.1
Delay disc. indifference point, 0s delay	0.8	0.9	1.1	-1.1	1.0	0.9	0.9
Delay disc. indifference point, 16s delay	4.2	6.0	7.9	-1.8	2.6	2.5	2.8
Delay disc. indifference point, 2s delay	0.1	0.1	0.3	-0.6	0.2	0.3	0.2
Delay disc. indifference point, 24s delay	0.1	0.2	0.4	0.2	0.5	0.2	0.6
Delay disc. indifference point, 4s delay	2.8	2.9	3.5	-1.7	1.9	1.7	1.6
Delay disc. indifference point, 8s delay	0.0	0.0	0.0	0.0	0.1	0.0	0.1
Indifference point function ln k	0.0	0.1	0.2	-0.1	0.5	0.2	0.4
Indifference point function log k	0.0	0.1	0.2	-0.1	0.5	0.2	0.4
Patch foraging total patch changes 0 sec	0.0	0.1	0.2	-0.1	0.1	-0.3	-0.5
Patch foraging total patch changes 12 sec	0.5	0.7	1.9	-1.4	0.7	0.8	0.0
Patch foraging total patch changes 18 sec	0.1	0.3	0.4	0.2	-0.5	-0.5	-0.7
Patch foraging total patch changes 24 sec	0.2	0.6	1.1	-1.1	0.8	0.9	0.3
Patch foraging total patch changes 6 sec	0.1	0.2	0.4	-0.6	0.6	0.2	-0.3
Patch foraging time to switch 0 sec	0.0	0.1	0.1	-0.3	0.2	0.3	0.2
Patch foraging water rate 0 sec	0.0	0.0	0.0	-0.1	0.1	-0.0	0.1
Patch foraging water rate 12 sec	0.0	0.0	0.1	-0.2	0.1	0.2	0.4
Patch foraging water rate 18 sec	0.2	0.6	1.0	-1.0	0.7	0.7	0.5
Patch foraging water rate 24 sec	0.0	0.0	0.1	-0.3	0.2	0.1	-0.1
Patch foraging water rate 6 sec	1.2	1.8	2.2	-1.5	1.3	1.3	1.3
Seeking ratio, delayed vs. immediate footshock	0.8	1.1	2.4	-0.5	1.0	0.8	1.5
Distance traveled before self-admin	0.2	0.4	0.6	-0.7	0.8	0.7	0.4
Distance traveled after self-admin	0.0	0.0	0.0	0.2	0.1	0.1	0.1
Extensor digitorum longus weight	5.0	19.8	29.7	5.5	-4.2	-4.3	-3.7
Bone: elastic displacement	0.5	0.7	0.7	0.8	-0.8	-0.8	-0.8
Bone: elastic work	0.1	0.2	0.3	-0.5	0.3	0.5	0.2
Bone: endosteal estimation	2.6	6.4	7.7	2.3	-2.6	-2.4	-2.8
Bone: endosteal perimeter	2.0	5.0	5.8	2.1	-2.4	-2.2	-2.2
Epididymis fat weight	0.0	0.2	0.3	0.4	-0.4	-0.4	-0.5
Delta time in closed arm before/after self-admin	1.0	0.9	1.3	1.1	-1.0	-0.8	-0.9
Delta time in open arm before/after self-admin	0.2	0.3	0.4	-0.4	0.7	0.5	0.5
Diff in mean of infusions in LGA sessions	0.0	0.1	0.2	-0.4	0.1	0.3	0.1
Delay discount exponential model param	1.3	1.8	2.2	1.0	-1.5	-1.3	-1.5
Extinction: sum of active levers before priming	0.6	0.9	1.1	1.0	-0.9	-0.9	-1.1
Active lever presses in extinction session 6	1.3	1.3	2.3	-1.5	1.0	1.3	0.4
Bone: final force	0.1	0.2	0.4	-0.6	0.1	0.2	-0.4
Bone: final moment	0.1	0.1	0.3	-0.5	-0.1	0.1	-0.5
Food consumed during 24 hour testing period	0.3	0.6	1.0	1.0	-0.7	-0.7	-0.8
Glucose	0.2	0.2	0.5	0.0	-0.6	-0.3	-0.7
Heart weight	2.0	3.3	4.1	2.0	-1.8	-1.7	-1.7
Delay discount hyperbolic model param	1.1	1.4	1.7	0.8	-1.3	-1.2	-1.3
Intermittent access intake day 1-15 change	0.2	0.9	1.2	-1.1	0.6	1.0	1.1
Intermittent access intake escalation	0.1	0.8	1.1	-1.0	0.5	0.9	1.0
Intermittent access intake escalation 2	0.0	0.1	0.3	0.0	-0.5	-0.1	0.1
Intermitt. access day 1 inactive lever presses	0.3	4.2	4.9	-2.2	2.2	2.2	1.6
Intermitt. access day 15 inactive lever presses	0.1	0.8	1.1	-1.1	0.9	0.7	0.8
Intermitt. access escalation Index	0.0	0.1	0.2	-0.0	0.2	0.5	0.1
Intermittent access day 1 total infusions	0.0	0.1	0.2	-0.0	0.4	0.2	0.2
Intermittent access day 15 total infusions	0.6	1.4	1.5	-1.1	1.1	1.2	1.2
Intermittent access terminal intake (last 3 days)	0.6	1.0	1.0	-1.0	1.0	1.0	1.0
Intermittent access total infusions	0.7	0.8	1.0	-0.7	1.0	0.9	1.0
Intermittent access day 1 locomotion	0.1	0.2	0.2	0.4	-0.4	-0.5	-0.3
Intermittent access day 15 total locomotion	0.0	0.1	0.3	0.2	-0.6	-0.4	-0.2
Intermittent access total locomotion	0.2	0.2	0.3	-0.5	0.3	0.4	0.6
Intermittent access standard deviation	0.4	1.9	2.3	-1.5	1.2	1.3	1.4
Left kidney weight	0.1	0.7	1.3	-0.5	0.6	1.0	1.1
Right kidney weight	0.1	0.6	0.9	-0.9	0.6	1.0	0.6
Cocaine induced anxiety	0.0	0.1	0.3	0.6	0.1	0.1	0.0
Post-drug Anxiety	0.1	0.2	0.4	0.1	0.6	0.4	0.4
Baseline Anxiety	0.0	0.1	0.1	-0.3	0.0	-0.2	-0.3
Tail length	0.0	0.1	0.3	0.5	0.1	0.1	0.2
Length with tail	0.5	2.1	3.4	1.8	-1.3	-1.3	-1.3
Length without tail	1.3	6.6	7.4	2.7	-2.5	-2.5	-2.5
Times rat made contact with spout	0.2	0.2	0.3	0.1	-0.4	-0.5	-0.5
Lifetime Intake	1.0	1.2	1.7	-1.0	1.3	1.1	1.0
Liver weight, left	0.5	0.9	1.2	1.0	-0.8	-0.9	-1.1
Liver weight, right	2.5	4.4	5.3	-2.0	2.1	2.3	2.0
Locomotor activity	0.1	0.2	0.4	-0.7	0.2	0.6	0.3
Locomotor testing distance	0.7	1.8	2.6	-1.6	1.1	1.3	1.2
Locomotor testing rearing	1.7	6.2	7.5	-2.7	2.5	2.5	2.2
Locomotion in novel chamber	2.9	3.9	4.8	-2.2	2.2	1.9	1.5
Locomotion in novel chamber post-restriction	0.0	0.1	0.3	-0.1	-0.3	-0.3	-0.6
Fecal boli incidents, locomotor time 1	0.7	1.7	2.1	1.2	-1.5	-1.4	-1.2
Change in fecal boli incidents, locomotor task	0.7	0.7	1.0	-0.5	0.7	1.0	1.0
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	-0.2	0.4	0.2	0.5
Bouts of movement, locomotor time 1	0.1	0.1	0.3	0.2	-0.2	-0.2	-0.5
Total resting periods, locomotor time 1	0.7	0.8	1.2	0.8	-0.8	-0.9	-1.1
Rest time, locomotor task time 1	1.2	2.0	4.1	0.9	-1.2	-1.3	-2.0
Distance moved, locomotor task time 1	0.8	2.3	3.8	-0.9	1.5	1.5	1.9
Vertical activity count, locomotor time 1	0.0	0.1	0.3	0.1	0.0	0.1	0.6
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.4	-0.7	0.2	0.5	0.1
Bouts of movement, locomotor time 2	0.2	0.6	0.7	-0.8	0.8	0.8	0.6
Total resting periods, locomotor time 2	0.1	0.5	0.7	-0.7	0.8	0.8	0.5
Rest time, locomotor task time 2	0.8	1.3	1.9	1.0	-1.0	-1.1	-1.4
Distance moved, locomotor task time 2	0.2	0.3	0.4	-0.2	0.5	0.6	0.6
Vertical activity count, locomotor time 2	0.0	0.0	0.1	0.3	-0.1	-0.0	-0.0
Light reinforcement 1	0.5	2.1	3.3	-1.8	1.4	1.4	1.1
Light reinforcement 2	0.3	0.7	0.9	-0.8	0.7	1.0	0.8
Bone: marrow area	2.5	6.0	7.2	2.2	-2.6	-2.3	-2.7
Bone: maximum diameter	0.1	0.1	0.2	-0.0	-0.4	-0.3	-0.5
Bone: maximum force	0.2	0.3	0.8	0.1	-0.6	-0.3	-0.9
Bone: maximum moment	0.2	0.4	0.9	0.3	-0.7	-0.5	-1.0
Mean time between licks in bursts	1.0	5.8	6.6	2.2	-2.6	-2.4	-2.5
Mean num. licks in bursts	0.1	0.2	0.4	-0.3	0.7	0.3	0.4
Cd content in liver	1.4	1.6	2.0	1.4	-1.1	-1.4	-1.1
Co content in liver	0.9	1.0	1.8	1.4	-0.8	-1.1	-0.7
Cu content in liver	0.6	0.7	1.0	-0.7	1.0	0.7	1.0
Fe content in liver	0.4	0.5	1.2	1.1	-0.5	-0.5	-0.6
K content in liver	5.0	4.9	5.8	-2.4	2.1	2.4	2.0
Mg content in liver	4.8	5.2	5.6	-2.3	2.2	2.3	2.4
Mn content in liver	2.4	2.7	3.6	-1.8	1.2	1.6	1.9
Na content in liver	0.4	0.5	1.4	-1.2	0.3	0.7	-0.0
Rb content in liver	0.3	0.4	0.5	-0.7	0.7	0.5	0.6
Se content in liver	9.2	10.8	12.6	-3.6	3.1	3.2	3.2
Sr content in liver	0.1	0.1	0.3	0.0	0.2	0.1	0.5
Zn content in liver	4.5	5.2	5.8	-2.4	2.4	2.2	2.2
Bone: minimum diameter	0.5	0.9	1.2	0.7	-1.1	-0.8	-1.1
Time in familiar zone, hab. session 1	0.1	0.1	0.2	-0.4	0.0	0.4	0.1
Time in novel zone, hab. session 1	0.1	0.2	0.4	-0.3	0.3	0.0	0.6
Total zone transitions, hab. session 1	0.3	0.5	1.4	1.2	-0.3	-0.5	-0.0
Total locomotion distance, hab. session 1	0.4	0.5	0.8	-0.3	0.8	0.7	0.9
Locomotion velocity, hab. session 1	0.2	0.3	0.5	-0.1	0.7	0.6	0.6
Time in familiar zone, hab. session 2	2.2	2.5	3.1	-1.5	1.4	1.7	1.8
Time in novel zone, hab. session 2	0.6	0.6	1.1	0.5	-0.6	-0.9	-1.0
Total zone transitions, hab. session 2	1.1	1.4	2.0	1.4	-1.1	-1.2	-0.9
Total locomotion distance, hab. session 2	0.6	0.8	0.9	1.0	-0.8	-0.9	-0.9
Locomotion velocity, hab. session 2	0.7	0.9	1.0	1.0	-0.9	-0.9	-1.0
Novel to familiar place preference ratio	0.2	0.2	0.4	-0.1	0.6	0.5	0.5
Novelty place preference	0.2	0.3	0.5	-0.1	0.7	0.6	0.6
Time in novel zone, NPP test	0.5	0.6	0.8	-0.4	0.9	0.8	0.8
Total zone transitions, NPP test	1.6	2.4	3.0	1.7	-1.5	-1.5	-1.3
Total locomotion distance, NPP test	0.7	1.0	1.1	1.0	-1.0	-0.9	-1.0
Locomotion velocity, NPP test	1.1	1.6	2.1	1.4	-1.2	-1.2	-1.2
Intraocular pressure	2.2	3.6	6.5	2.5	-1.4	-1.9	-1.5
Delta distance traveled before/after self-admin	0.1	0.2	0.4	0.6	-0.4	-0.2	0.1
Delta ambulatory time before/after self-admin	0.3	0.4	0.8	0.9	-0.8	-0.5	-0.3
Parametrial fat weight	0.1	0.2	0.4	-0.6	0.4	0.3	-0.2
Pavlov. Cond. lever latency	0.2	0.3	0.6	0.8	-0.5	-0.3	0.2
Pavlov. Cond. magazine entry latency	3.8	4.9	8.6	-2.9	2.1	2.1	1.5
Pavlov. Cond. change in total contacts	6.2	6.7	8.0	-2.8	2.8	2.4	2.2
Pavlov. Cond. index score	1.8	2.3	4.6	-2.2	1.5	1.3	0.8
Pavlov. Cond. latency score	1.2	1.5	3.3	-1.8	1.2	1.0	0.4
Pavlov. Cond. lever contacts	0.2	0.3	0.7	-0.9	0.5	0.3	-0.2
Pavlov. Cond. magazine entry number	5.4	6.8	10.2	3.2	-2.6	-2.4	-2.1
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.9	0.9	-0.5	-0.6	-0.1
Pavlov. Cond. lever-magazine prob. diff.	2.4	3.0	5.8	-2.4	1.7	1.5	1.0
Pavlov. Cond. response bias	4.3	5.4	7.9	-2.8	2.4	2.2	1.8
Pavlov. Cond. lever latency	0.1	0.1	0.2	0.5	-0.1	-0.3	-0.2
Pavlov. Cond. magazine entry latency	0.1	0.2	0.2	0.4	-0.3	-0.4	-0.5
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	-0.1	-0.2	-0.1	-0.0
Pavlov. Cond. index score	0.0	0.1	0.2	0.2	-0.4	-0.2	-0.3
Pavlov. Cond. latency score	0.1	0.1	0.2	0.3	-0.5	-0.3	-0.3
Pavlov. Cond. lever contacts	0.0	0.0	0.1	-0.4	-0.0	0.2	0.0
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	0.1	-0.0	-0.2	-0.1
Pavlov. Cond. intertrial magazine entries	0.1	0.3	0.8	0.9	-0.1	-0.5	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	0.3	-0.4	-0.2	-0.3
Pavlov. Cond. response bias	0.2	0.2	0.5	-0.7	0.3	0.5	0.3
Time in closed arm before self-admin	1.2	2.0	3.2	-1.2	1.2	1.3	1.8
Time in closed arm after self-admin	1.0	1.1	2.5	-0.6	0.7	1.1	1.6
Time in open arm before self-admin	0.4	0.5	1.1	0.6	-0.7	-0.5	-1.1
Time in open arm after self-admin	0.3	0.3	0.7	0.4	-0.3	-0.5	-0.8
Bone: periosteal estimation	0.6	1.5	2.3	0.8	-1.3	-1.1	-1.5
Bone: periosteal perimeter	1.3	2.5	3.1	1.4	-1.8	-1.5	-1.7
Bone: post-yield work	0.8	1.4	1.8	1.3	-1.1	-1.1	-1.2
Progressive ratio test 1 active lever presses	0.2	0.3	0.5	-0.5	0.7	0.6	0.5
Progressive ratio test 1 breakpoint	0.1	0.2	0.3	-0.4	0.5	0.5	0.4
Progressive ratio test 1 inactive lever presses	0.3	0.7	1.2	-0.8	1.1	0.8	0.4
Progressive ratio test 2 active lever presses	0.2	0.3	0.4	-0.6	0.6	0.4	0.5
Progressive ratio test 2 breakpoint	0.2	0.3	0.4	-0.6	0.6	0.4	0.5
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.0	-0.2	0.2	0.1	0.2
Incentive Sensitization - Responses	0.0	0.1	0.2	-0.0	-0.2	-0.5	-0.2
Incentive Sensitization - Breakpoint	0.0	0.1	0.2	-0.1	-0.2	-0.4	-0.1
Sum of active levers in priming session hrs 5-6	0.9	0.9	1.3	-1.1	0.9	1.1	0.5
Progressive ratio	0.1	0.2	0.3	-0.5	0.4	0.4	-0.1
Food seeking constrained by brief footshock	0.3	0.3	0.5	-0.7	0.5	0.6	0.4
Seeking ratio, punishment vs. effort	0.0	0.0	0.1	0.2	-0.0	-0.0	0.4
Retroperitoneal fat weight	0.0	0.1	0.2	-0.2	0.4	0.4	0.4
Reaction time number correct	0.4	1.5	1.6	1.2	-1.2	-1.3	-1.2
Reaction time mean minus median	0.3	2.2	3.0	1.3	-1.4	-1.5	-1.7
Reaction time mean minus median AUC	0.1	0.9	1.3	0.8	-0.8	-1.0	-1.1
Reaction time num false alarms	0.1	0.1	0.3	-0.0	-0.5	-0.3	-0.3
Reaction time num false alarms AUC	0.2	0.5	0.9	0.3	-1.0	-0.6	-0.6
Reaction time trials correct on left	0.4	1.5	1.6	1.2	-1.2	-1.3	-1.2
Reaction time trials on left	0.4	1.5	1.6	1.2	-1.2	-1.2	-1.2
Reaction time mean	0.5	1.0	1.1	-1.0	1.0	1.0	1.0
Reaction time mean AUC	0.5	1.3	1.4	-1.2	1.1	1.1	1.1
Median of all reaction times	2.1	3.3	3.6	-1.8	1.7	1.8	1.9
Reaction time omissions	0.2	0.4	0.6	-0.8	0.6	0.5	0.6
Reaction time false alarm rate	0.0	0.1	0.2	-0.4	-0.2	0.1	0.1
Reaction time premature initiation rate	2.8	4.3	5.3	-2.0	2.1	2.3	1.8
Reaction time premature initiations	0.4	1.1	1.5	-1.0	1.1	1.2	0.8
Std. dev. reaction times	0.1	0.3	0.6	0.2	-0.5	-0.6	-0.8
Reaction time trials completed	0.4	1.5	1.6	1.2	-1.2	-1.2	-1.2
Reaction time trials AUC	0.5	1.6	1.7	1.3	-1.3	-1.3	-1.2
Run reversals in cocaine runway, females	0.8	0.9	1.4	-0.2	1.2	1.0	1.1
Run reversals in cocaine runway, males	0.2	0.2	0.4	-0.3	0.6	0.3	0.4
Latency to leave start box in cocaine runway	0.5	0.6	1.0	1.0	-0.9	-0.7	-0.4
Latency to leave start box in cocaine runway, F	0.2	0.3	0.6	0.8	-0.4	-0.4	-0.2
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	0.1	-0.3	-0.0	0.2
Std. dev. time between licks in bursts	0.5	0.9	1.4	0.5	-1.2	-0.8	-1.1
Total sessions with >9 infusions	1.1	1.3	1.8	-0.9	1.4	1.2	1.1
Short access day 1 total inactive lever presses	0.5	1.0	1.7	-1.1	1.3	0.9	0.4
Short access day 10 total inactive lever presses	0.0	0.1	0.1	0.3	-0.1	-0.4	-0.3
Short access day 1 total infusions	1.8	3.6	5.3	-1.7	2.3	2.0	1.5
Short access day 10 total infusions	0.4	0.7	0.9	-0.8	0.9	0.8	0.7
Short access total infusions	1.6	2.2	3.1	-1.4	1.8	1.5	1.2
Short access day 1 locomotion	1.6	2.6	3.3	-1.5	1.8	1.7	1.4
Short access day 10 total locomotion	0.0	0.1	0.2	-0.2	-0.4	-0.2	-0.1
Short access total locomotion	0.0	0.0	0.0	-0.1	0.1	0.2	0.2
One hour access (0.3 mA shock)	0.1	0.1	0.2	0.3	-0.2	-0.3	-0.4
Compulsive drug intake	0.0	0.0	0.1	0.1	0.2	-0.1	0.1
One hour access (shock baseline)	0.1	0.3	0.4	-0.6	0.6	0.7	0.4
Social response proportion	0.1	0.1	0.3	0.1	0.2	0.3	0.5
Social responses	0.0	0.1	0.1	-0.1	0.2	0.3	0.4
Social time	1.1	1.8	2.8	1.0	-1.2	-1.4	-1.7
Soleus weight	0.5	1.6	2.3	0.8	-1.4	-1.1	-1.5
Bone: stiffness	0.1	0.2	0.3	-0.5	0.4	0.6	-0.0
Tibialis anterior weight	0.5	1.6	2.7	1.6	-1.1	-1.1	-1.2
Time to tail flick, vehicle, before self-admin	1.8	2.3	2.9	1.4	-1.5	-1.7	-1.3
Time to tail flick, vehicle, after self-admin	0.5	1.0	2.2	0.6	-0.7	-1.0	-1.5
Time to tail flick, test, before self-admin	0.2	0.3	0.6	0.8	-0.5	-0.5	-0.2
Time to tail flick, test, after self-admin	1.3	1.4	1.7	1.1	-1.3	-1.2	-1.1
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	1.3	-0.2	-0.3	-0.4	-1.2
Delta time to tail flick, test, before/after SA	0.0	0.0	0.1	-0.2	0.0	-0.1	-0.2
Tibia length	0.8	2.2	2.5	1.6	-1.4	-1.4	-1.6
Ambulatory time before self-admin	0.1	0.2	0.3	-0.4	0.6	0.4	0.4
Ambulatory time after self-admin	0.1	0.1	0.3	0.5	-0.3	-0.3	-0.3
Bone: tissue strength	2.8	3.0	3.1	1.7	-1.7	-1.7	-1.7
Total heroin consumption	0.4	0.5	1.4	-1.2	0.4	0.6	0.2
Bone: trabecular number	1.8	3.5	6.7	-2.6	1.6	1.8	1.2
Bone: trabecular spacing	1.2	1.8	2.5	1.6	-1.2	-1.2	-1.3
Bone: trabecular thickness	0.2	0.2	0.5	0.1	-0.7	-0.5	-0.4
Bone: trabecular tissue density	0.2	0.3	0.6	-0.1	0.8	0.5	0.6
Water consumed over 24 hours	0.6	1.3	1.5	1.0	-1.2	-1.0	-1.2
Number of responses in last shaping day	0.1	0.1	0.2	-0.4	0.2	0.3	0.4