Krt2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	IL	intron excision ratio	chr7_134820595_134821630	0.42	0.21	7.6e-03	0.03	0.05	0.13	0.12	6.3e-02	2.4e-02	5.4e-04	9.7e-04
2	Liver	gene expression	Krt2	0.1	0.06	1.7e-04	0	0.03	0.03	0.02	3.7e-01	3.3e-04	6.3e-04	1.7e-03
3	Adipose	gene expression	Krt2	0.14	0.07	2.7e-07	0.06	0.07	0.07	0.07	5.3e-07	4.2e-08	7.1e-08	3.4e-08
4	NAcc	gene expression	Krt2	0.29	0.02	1.1e-06	0.04	0.04	0.04	0.04	1.0e-06	1.9e-07	3.4e-06	2.3e-07
5	PL	gene expression	Krt2	0.12	0.09	1.3e-03	0.03	0.03	0.03	0.03	3.5e-04	4.8e-04	1.5e-04	3.0e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.5	0.9	4.2	2.1	0.2	-0.1	-0.0	0.0
Area under the delay curve	0.1	0.2	0.8	0.9	0.3	0.2	0.1	-0.1
BMI with tail	1.1	3.7	15.8	4.0	1.3	1.0	0.5	-0.1
BMI without tail	0.2	1.1	4.0	2.0	0.9	0.7	0.4	-0.3
Body weight	0.3	1.3	6.4	2.5	0.3	-0.0	-0.4	0.3
Weight adjusted by age	1.2	3.5	6.0	0.6	-1.9	-1.4	-2.5	2.3
Bone surface	0.9	1.8	5.6	2.4	1.1	0.8	0.9	-0.9
Bone volume	0.9	1.8	5.5	2.3	1.2	0.8	0.9	-0.9
Breakpoint value in progressive ratio session	1.1	1.9	2.8	1.1	1.5	1.3	1.7	-1.3
Number of licking bursts	0.3	0.9	1.2	-1.1	0.8	0.9	0.9	-0.9
Context. condit. distance diff. score	1.7	2.1	3.8	-0.3	1.4	1.3	1.7	-2.0
Locomotion velocity, session 1	3.4	3.9	12.8	-3.6	-1.6	-1.7	-1.0	0.5
Locomotion distance, session 1	2.0	2.6	7.1	-2.7	-1.4	-1.3	-1.2	0.9
Locomotion velocity, session 2	3.8	4.5	6.3	-1.8	-2.3	-2.5	-2.1	1.8
Locomotion distance, session 2	1.7	2.4	6.7	-2.6	-1.4	-1.2	-1.1	0.7
Locomotion velocity, session 3	2.1	2.4	6.5	-2.6	-1.4	-1.7	-0.7	0.3
Locomotion distance, session 3	1.5	1.7	5.1	-2.3	-1.1	-1.3	-0.5	-0.0
Stereotopy head waving bouts, day 3	1.2	1.5	1.9	1.3	1.4	1.4	1.1	-0.8
Stereotopy head waving duration, day 3	0.2	0.3	0.3	0.4	0.6	0.5	0.5	-0.6
Locomotion velocity, session 7	1.6	1.8	3.8	-1.9	0.6	0.8	1.2	-1.6
Locomotion distance, session 7	1.6	2.0	7.0	-2.6	-1.2	-1.1	-0.6	0.0
Stereotopy head waving bouts, day 7	2.2	2.5	4.0	1.5	1.9	2.0	1.4	-0.9
Stereotopy head waving duration, day 7	1.6	2.0	2.8	1.4	1.7	1.6	1.3	-0.9
Locomotion velocity, session 8	0.8	1.0	1.8	-1.0	0.7	0.6	1.0	-1.3
Locomotion distance, session 8	1.0	1.5	6.5	-2.5	-0.7	-0.7	-0.1	-0.4
Degree of sensitization distance	0.1	0.1	0.3	0.1	0.3	0.6	0.1	-0.1
Degree of sensitization stereotypy	1.5	1.6	2.5	1.2	1.5	1.6	1.2	-0.7
Conditioned locomotion	0.4	0.5	2.2	-1.5	-0.2	-0.4	-0.1	-0.2
Cocaine response after cond. corrected	0.7	1.0	1.6	-0.8	-0.9	-0.7	-1.1	1.2
Cocaine response after cond. not corrected	0.6	0.8	1.2	-0.7	-1.0	-0.7	-1.0	1.1
Cocaine response before conditioning	0.4	0.5	1.1	-0.5	0.3	0.3	0.9	-1.1
Saline control response	0.6	0.8	1.4	-0.8	0.7	0.9	1.0	-1.2
Bone: connectivity density	0.1	0.2	0.6	0.8	-0.3	-0.3	-0.2	0.2
Bone: cortical apparent density	0.3	0.5	1.3	-0.5	-0.4	0.2	-0.9	1.1
Bone: cortical area	0.7	1.1	5.1	2.3	0.4	0.3	0.1	0.1
Bone: cortical porosity	0.3	0.3	0.7	-0.9	-0.6	-0.7	-0.2	-0.1
Bone: cortical porosity	0.3	0.3	0.6	-0.8	-0.7	-0.7	-0.3	0.0
Bone: cortical thickness	0.3	0.5	1.3	1.1	-0.4	-0.3	-0.7	0.8
Bone: cortical thickness	3.6	4.4	6.3	-0.3	-2.5	-2.1	-2.3	2.4
Bone: cortical tissue density	0.4	0.6	1.5	-0.6	-0.5	0.1	-1.0	1.2
Condit. Reinf. active minus inactive responses	0.3	0.4	1.4	-1.2	-0.3	-0.5	-0.2	0.2
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.8	-0.7	-0.6	-0.9	-0.5	0.6
Condit. Reinf. active responses	0.9	1.1	2.9	-1.7	-0.9	-1.1	-0.6	0.5
Condit. Reinf. inactive responses	0.9	1.1	3.4	-1.8	-0.9	-0.8	-0.6	0.3
Incentive salience index mean	0.1	0.1	0.4	-0.7	-0.1	-0.3	-0.0	0.2
Condit. Reinf. lever presses	0.1	0.1	0.3	0.0	0.5	0.4	0.4	-0.0
Condit. Reinf. active minus inactive responses	0.4	0.7	1.3	0.9	0.9	1.1	0.6	-0.4
Condit. Reinf. active-inactive response ratio	0.1	0.2	0.6	0.7	0.5	0.5	0.3	-0.2
Condit. Reinf. active responses	1.2	1.7	3.2	0.5	1.5	1.8	1.3	-1.2
Condit. Reinf. inactive responses	0.4	0.5	0.9	-0.6	0.7	1.0	0.8	-0.7
Condit. Reinf. lever presses	0.4	0.5	0.9	-0.9	0.3	0.5	0.7	-1.0
Condit. Reinf. lever reinforcers received	0.8	1.1	2.0	-0.0	1.1	1.4	1.1	-1.1
Conditioned reinforcement - actives	0.4	1.6	2.4	-1.5	1.1	1.2	1.4	-1.2
Conditioned reinforcement - inactives	0.1	0.4	1.1	-1.1	-0.6	-0.2	-0.3	0.3
Conditioned locomotion	0.9	1.3	1.9	-1.0	1.0	1.0	1.4	-1.3
Patch foraging indifference point 0 sec	0.3	1.0	4.7	-2.2	-0.0	0.1	0.3	-0.3
Patch foraging indifference point AUC	0.1	0.3	1.3	-1.1	0.1	0.3	-0.2	0.4
Delay disc. indifference point, 0s delay	0.3	0.3	0.8	0.2	-0.6	-0.4	-0.9	0.6
Delay disc. indifference point, 16s delay	0.1	0.2	0.8	0.9	0.2	0.1	0.0	0.1
Delay disc. indifference point, 2s delay	2.2	2.5	4.0	1.7	1.9	2.0	1.2	-0.6
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	0.5	0.3	0.2	0.3	-0.2
Delay disc. indifference point, 4s delay	0.4	0.5	0.7	0.8	0.8	0.6	0.5	-0.6
Delay disc. indifference point, 8s delay	0.0	0.0	0.1	0.3	-0.0	-0.2	0.0	-0.3
Indifference point function ln k	0.2	0.6	2.4	1.5	0.3	-0.2	0.3	-0.5
Indifference point function log k	0.2	0.6	2.4	1.5	0.3	-0.2	0.3	-0.5
Patch foraging total patch changes 0 sec	0.4	1.2	5.9	-2.4	-0.3	-0.2	0.0	-0.2
Patch foraging total patch changes 12 sec	0.9	1.3	5.7	-2.4	0.2	0.6	0.3	-0.3
Patch foraging total patch changes 18 sec	0.7	1.6	7.5	-2.7	0.0	0.5	0.4	-0.1
Patch foraging total patch changes 24 sec	0.4	1.3	2.8	-1.7	0.9	1.1	1.0	-0.8
Patch foraging total patch changes 6 sec	0.7	1.1	5.5	-2.3	0.1	0.4	-0.0	-0.1
Patch foraging time to switch 0 sec	0.0	0.1	0.1	0.3	-0.2	0.2	-0.3	0.4
Patch foraging water rate 0 sec	0.0	0.2	0.4	0.1	0.5	0.2	0.6	-0.5
Patch foraging water rate 12 sec	0.0	0.2	0.3	-0.3	-0.0	-0.3	0.5	-0.6
Patch foraging water rate 18 sec	0.2	0.5	0.8	-0.4	0.6	0.6	0.8	-0.9
Patch foraging water rate 24 sec	0.9	1.3	1.7	0.4	1.3	1.2	1.3	-1.3
Patch foraging water rate 6 sec	0.5	0.8	1.5	0.9	0.7	0.3	1.2	-1.0
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.2	0.0	-0.4	-0.3	-0.3	0.1
Distance traveled before self-admin	0.0	0.0	0.0	0.1	0.2	0.1	-0.0	-0.1
Distance traveled after self-admin	0.8	1.4	2.7	-0.6	0.9	0.6	1.6	-1.6
Extensor digitorum longus weight	2.5	10.0	31.4	5.6	3.1	2.9	1.0	-0.4
Bone: elastic displacement	1.4	1.8	7.2	-2.7	-0.6	-0.8	0.1	-0.9
Bone: elastic work	1.5	2.0	4.0	-1.0	-1.6	-2.0	-1.3	0.7
Bone: endosteal estimation	1.0	2.5	6.3	2.5	1.4	1.0	1.2	-1.3
Bone: endosteal perimeter	0.9	2.3	9.1	3.0	1.1	0.7	0.7	-0.5
Epididymis fat weight	0.5	2.5	6.0	-0.8	-2.0	-2.5	-1.2	0.6
Delta time in closed arm before/after self-admin	1.1	1.0	1.3	0.5	1.1	1.0	1.2	-1.0
Delta time in open arm before/after self-admin	3.1	3.7	5.7	-1.2	-2.4	-2.4	-1.9	1.4
Diff in mean of infusions in LGA sessions	0.4	0.7	1.1	0.9	-0.7	-0.4	-1.0	1.0
Delay discount exponential model param	0.2	0.3	1.1	-1.1	-0.4	-0.4	-0.2	0.2
Extinction: sum of active levers before priming	0.7	1.0	4.4	2.1	0.7	0.4	0.1	-0.1
Active lever presses in extinction session 6	0.4	0.4	0.6	0.5	0.7	0.4	0.7	-0.8
Bone: final force	0.9	1.5	7.5	2.7	0.3	-0.1	-0.1	0.1
Bone: final moment	1.0	1.7	7.9	2.8	0.6	0.1	0.1	-0.2
Food consumed during 24 hour testing period	0.1	0.2	0.5	-0.2	0.1	-0.0	0.5	-0.7
Glucose	0.3	0.5	1.6	-1.3	-0.6	-0.6	-0.5	0.2
Heart weight	0.2	0.3	1.0	1.0	-0.4	-0.4	-0.2	0.2
Delay discount hyperbolic model param	0.3	0.4	1.3	-1.2	-0.5	-0.5	-0.2	0.2
Intermittent access intake day 1-15 change	0.1	0.4	0.8	-0.5	0.5	0.2	0.8	-0.9
Intermittent access intake escalation	0.0	0.1	0.1	-0.3	0.1	-0.1	0.2	-0.3
Intermittent access intake escalation 2	0.0	0.0	0.2	-0.4	-0.1	-0.1	0.0	-0.2
Intermitt. access day 1 inactive lever presses	0.1	0.6	1.2	1.0	0.8	1.1	0.7	-0.2
Intermitt. access day 15 inactive lever presses	0.0	0.1	0.2	0.3	-0.4	-0.2	-0.3	0.4
Intermitt. access escalation Index	0.5	1.7	3.1	0.3	1.7	1.7	1.3	-0.8
Intermittent access day 1 total infusions	0.3	0.9	1.5	-1.2	0.8	0.8	1.1	-0.7
Intermittent access day 15 total infusions	0.5	1.1	3.6	-1.9	0.7	0.6	0.9	-0.6
Intermittent access terminal intake (last 3 days)	1.3	2.3	3.0	-1.7	1.4	1.4	1.7	-1.3
Intermittent access total infusions	1.8	2.2	2.8	-1.5	1.5	1.5	1.7	-1.2
Intermittent access day 1 locomotion	1.1	1.9	3.0	-1.2	1.4	1.2	1.7	-1.3
Intermittent access day 15 total locomotion	0.1	0.3	0.7	-0.4	0.2	-0.2	0.7	-0.8
Intermittent access total locomotion	1.0	1.2	2.2	-1.0	1.1	0.8	1.5	-1.1
Intermittent access standard deviation	0.1	0.6	1.2	-1.1	-0.8	-0.9	-0.6	0.3
Left kidney weight	0.2	1.8	2.8	1.0	-1.2	-1.2	-1.7	1.5
Right kidney weight	0.5	3.3	5.2	2.3	-1.3	-1.3	-2.1	1.9
Cocaine induced anxiety	0.3	0.8	1.3	0.3	1.0	0.5	1.2	-1.1
Post-drug Anxiety	1.2	1.4	2.5	0.7	1.2	0.8	1.6	-1.5
Baseline Anxiety	0.4	0.7	1.0	0.7	-1.0	-0.6	-0.9	0.9
Tail length	0.2	0.8	3.6	-1.9	-0.3	-0.4	-0.1	-0.5
Length with tail	0.1	0.4	0.6	-0.4	-0.7	-0.8	-0.7	0.3
Length without tail	0.1	0.3	1.4	1.2	-0.1	-0.3	-0.2	0.1
Times rat made contact with spout	0.1	0.1	0.4	-0.0	0.2	-0.1	0.5	-0.7
Lifetime Intake	2.0	2.5	3.7	-1.4	1.6	1.6	1.9	-1.4
Liver weight, left	1.4	2.4	8.2	2.9	1.2	0.5	1.0	-1.0
Liver weight, right	0.7	1.2	2.1	1.5	-0.9	-1.0	-1.2	1.0
Locomotor activity	0.0	0.1	0.2	-0.4	-0.1	0.0	-0.1	-0.3
Locomotor testing distance	0.2	0.6	1.7	-1.3	0.2	0.4	0.5	-1.0
Locomotor testing rearing	0.1	0.2	0.3	-0.5	-0.5	-0.5	-0.5	0.0
Locomotion in novel chamber	1.4	1.9	5.5	2.3	1.3	1.1	0.7	-0.6
Locomotion in novel chamber post-restriction	0.5	1.5	2.4	0.0	1.4	1.6	1.4	-1.1
Fecal boli incidents, locomotor time 1	0.6	1.6	3.4	-1.9	-1.3	-1.5	-0.8	0.2
Change in fecal boli incidents, locomotor task	0.3	0.3	0.6	0.4	0.6	0.8	0.4	-0.1
Time >=10cm from walls, locomotor time 1	0.2	0.3	0.9	-0.9	-0.2	-0.2	0.4	-0.4
Bouts of movement, locomotor time 1	0.5	0.7	1.1	-1.1	-0.9	-0.7	-0.7	0.7
Total resting periods, locomotor time 1	1.3	1.5	2.3	-1.5	-1.3	-1.3	-1.0	0.9
Rest time, locomotor task time 1	0.3	0.6	2.1	-1.4	-0.3	-0.7	-0.2	0.0
Distance moved, locomotor task time 1	0.4	1.2	2.7	0.6	1.1	1.6	1.0	-0.9
Vertical activity count, locomotor time 1	0.1	0.8	2.5	1.6	0.6	1.1	0.2	0.2
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.4	-0.6	0.1	0.2	0.4	-0.4
Bouts of movement, locomotor time 2	0.4	1.4	3.0	1.7	1.1	1.3	0.7	-0.6
Total resting periods, locomotor time 2	0.4	1.5	3.0	1.7	1.2	1.5	0.8	-0.6
Rest time, locomotor task time 2	0.2	0.3	1.6	-1.2	0.1	-0.2	0.1	0.1
Distance moved, locomotor task time 2	0.2	0.2	0.4	0.4	-0.5	-0.2	-0.6	0.6
Vertical activity count, locomotor time 2	0.2	0.4	1.0	1.0	-0.2	-0.2	-0.6	0.7
Light reinforcement 1	0.1	0.5	1.6	-1.3	-0.5	0.3	-0.3	0.6
Light reinforcement 2	0.7	1.7	2.5	-1.1	-1.4	-1.0	-1.3	1.6
Bone: marrow area	1.0	2.4	6.0	2.4	1.4	1.0	1.2	-1.3
Bone: maximum diameter	0.7	1.4	2.7	1.6	1.2	1.0	1.1	-0.9
Bone: maximum force	0.7	1.4	6.0	2.4	0.7	0.5	0.2	-0.3
Bone: maximum moment	0.8	1.6	6.2	2.5	0.9	0.6	0.4	-0.6
Mean time between licks in bursts	0.1	0.8	3.7	-1.9	-0.0	-0.1	0.2	-0.7
Mean num. licks in bursts	0.2	0.7	1.3	0.8	-0.8	-1.2	-0.6	0.5
Cd content in liver	0.5	0.5	1.4	-1.2	0.4	0.2	0.7	-0.8
Co content in liver	0.2	0.2	0.3	0.2	0.5	0.5	0.4	-0.5
Cu content in liver	5.7	6.8	8.9	2.5	2.7	2.1	3.0	-2.6
Fe content in liver	0.4	0.5	0.9	-0.6	0.7	0.6	0.7	-1.0
K content in liver	0.2	0.2	0.8	0.9	0.5	-0.0	0.2	-0.2
Mg content in liver	0.7	0.8	1.5	0.2	1.0	0.5	1.1	-1.2
Mn content in liver	0.1	0.1	0.2	-0.3	-0.2	-0.2	-0.4	0.2
Na content in liver	0.7	0.8	1.0	0.8	1.0	0.6	1.0	-0.9
Rb content in liver	3.9	4.5	7.7	-0.1	2.3	1.7	2.6	-2.8
Se content in liver	0.2	0.3	0.7	-0.9	-0.4	-0.6	-0.2	0.0
Sr content in liver	0.8	0.7	1.0	-0.2	-0.9	-0.9	-1.0	0.7
Zn content in liver	0.1	0.1	0.4	-0.6	-0.3	-0.4	0.3	-0.2
Bone: minimum diameter	1.0	1.8	7.2	2.7	0.9	0.7	0.6	-0.5
Time in familiar zone, hab. session 1	1.0	1.1	1.8	0.1	-1.2	-1.3	-1.1	1.0
Time in novel zone, hab. session 1	1.6	1.8	3.2	0.3	1.6	1.8	1.4	-1.1
Total zone transitions, hab. session 1	0.1	0.2	0.6	-0.8	-0.0	0.4	-0.1	0.3
Total locomotion distance, hab. session 1	1.0	1.4	2.1	-1.4	-1.3	-1.0	-1.0	1.1
Locomotion velocity, hab. session 1	1.1	1.5	1.9	-1.3	-1.4	-1.1	-1.2	1.2
Time in familiar zone, hab. session 2	0.1	0.1	0.6	0.7	0.2	-0.3	0.1	-0.2
Time in novel zone, hab. session 2	0.3	0.3	0.8	-0.4	0.5	0.9	0.4	-0.5
Total zone transitions, hab. session 2	0.6	0.8	1.0	-1.0	-1.0	-0.8	-0.8	0.9
Total locomotion distance, hab. session 2	2.2	2.9	3.8	-0.8	-2.0	-1.8	-1.8	1.9
Locomotion velocity, hab. session 2	2.7	3.6	4.8	-0.8	-2.2	-2.0	-2.0	2.1
Novel to familiar place preference ratio	0.2	0.2	0.9	0.9	0.1	0.2	-0.2	0.5
Novelty place preference	0.1	0.1	0.4	0.7	0.2	0.2	-0.1	0.2
Time in novel zone, NPP test	0.1	0.2	0.5	0.7	0.3	0.4	0.0	0.1
Total zone transitions, NPP test	1.6	2.4	5.2	-2.3	-1.5	-1.2	-1.2	1.3
Total locomotion distance, NPP test	5.0	6.9	8.8	-2.0	-3.0	-2.7	-2.6	2.8
Locomotion velocity, NPP test	5.6	8.0	10.3	-2.0	-3.2	-2.9	-2.8	3.0
Intraocular pressure	2.7	4.3	6.4	-2.2	1.5	1.7	2.4	-2.5
Delta distance traveled before/after self-admin	0.5	0.5	0.8	-0.8	-0.3	-0.6	0.8	-0.9
Delta ambulatory time before/after self-admin	0.3	0.6	1.4	-0.5	-0.0	-0.3	1.0	-1.2
Parametrial fat weight	0.9	2.0	3.9	-2.0	0.8	0.6	1.6	-1.6
Pavlov. Cond. lever latency	1.6	2.0	3.0	-0.5	-1.7	-1.7	-1.5	1.1
Pavlov. Cond. magazine entry latency	1.4	1.8	2.9	1.1	1.7	1.7	1.2	-0.8
Pavlov. Cond. change in total contacts	2.3	2.4	3.6	1.6	1.9	1.8	1.5	-0.9
Pavlov. Cond. index score	2.5	3.1	4.8	1.6	2.2	2.2	1.6	-1.0
Pavlov. Cond. latency score	3.0	3.8	5.6	1.5	2.4	2.4	1.9	-1.4
Pavlov. Cond. lever contacts	1.5	1.8	2.8	0.6	1.7	1.7	1.4	-1.0
Pavlov. Cond. magazine entry number	1.1	1.3	2.2	-0.9	-1.4	-1.5	-1.1	0.7
Pavlov. Cond. intertrial magazine entries	1.1	1.4	4.7	-2.2	-1.0	-1.0	-0.4	0.2
Pavlov. Cond. lever-magazine prob. diff.	2.5	3.1	4.8	1.5	2.2	2.2	1.6	-1.1
Pavlov. Cond. response bias	0.7	0.9	1.6	0.6	1.2	1.2	1.0	-0.6
Pavlov. Cond. lever latency	0.5	0.6	2.6	1.6	0.4	0.2	-0.3	0.4
Pavlov. Cond. magazine entry latency	2.3	3.3	4.8	-1.6	-2.2	-2.1	-1.7	1.4
Pavlov. Cond. change in total contacts	0.2	0.5	0.9	0.6	0.8	1.0	0.8	-0.4
Pavlov. Cond. index score	0.8	1.2	2.6	-1.6	-1.3	-1.0	-0.7	0.5
Pavlov. Cond. latency score	0.8	1.3	2.4	-1.6	-1.4	-1.1	-0.8	0.7
Pavlov. Cond. lever contacts	0.6	0.9	3.5	-1.9	-0.8	-0.5	0.1	-0.3
Pavlov. Cond. magazine entry number	0.7	0.9	1.5	0.9	1.2	1.0	0.8	-0.8
Pavlov. Cond. intertrial magazine entries	0.2	0.5	1.2	-1.1	0.1	-0.1	0.5	-0.9
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.9	1.5	-1.2	-1.2	-1.0	-0.7	0.6
Pavlov. Cond. response bias	0.5	0.6	2.2	-1.5	-0.8	-0.6	-0.1	-0.1
Time in closed arm before self-admin	0.3	0.5	1.1	0.5	-0.3	0.0	-1.0	1.0
Time in closed arm after self-admin	1.6	1.8	3.7	0.8	1.7	1.9	1.2	-0.7
Time in open arm before self-admin	2.3	2.8	4.1	0.7	2.0	1.8	1.9	-1.5
Time in open arm after self-admin	0.8	0.9	1.8	-0.2	-1.2	-1.3	-0.9	0.7
Bone: periosteal estimation	1.3	3.1	10.0	3.2	1.4	1.0	1.1	-1.0
Bone: periosteal perimeter	1.3	2.5	9.5	3.1	1.2	0.9	0.7	-0.4
Bone: post-yield work	0.5	0.9	1.9	1.4	0.9	0.8	0.6	-0.8
Progressive ratio test 1 active lever presses	1.4	2.5	6.9	-2.6	1.0	1.0	1.4	-1.1
Progressive ratio test 1 breakpoint	1.6	2.7	7.3	-2.7	1.1	1.0	1.6	-1.2
Progressive ratio test 1 inactive lever presses	0.1	0.3	1.0	-0.3	0.5	1.0	0.5	0.1
Progressive ratio test 2 active lever presses	2.3	3.2	5.4	-0.5	2.0	1.9	2.3	-1.7
Progressive ratio test 2 breakpoint	2.5	3.2	5.2	-0.4	2.0	2.0	2.3	-1.6
Progressive ratio test 2 inactive lever presses	0.3	1.0	1.9	-0.1	1.0	1.0	1.4	-0.9
Incentive Sensitization - Responses	0.6	1.7	2.2	1.1	1.5	1.4	1.5	-1.0
Incentive Sensitization - Breakpoint	0.8	1.8	2.4	1.3	1.5	1.5	1.5	-0.9
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.1	0.3	0.0	0.1	-0.2	0.3
Progressive ratio	0.1	0.2	0.3	-0.4	0.5	0.4	0.4	-0.6
Food seeking constrained by brief footshock	1.4	1.8	3.3	-0.5	1.4	1.5	1.8	-1.2
Seeking ratio, punishment vs. effort	0.1	0.1	0.3	0.1	0.3	0.4	0.6	-0.2
Retroperitoneal fat weight	0.7	3.1	12.1	-3.5	-0.9	-1.2	0.3	-0.9
Reaction time number correct	0.1	0.2	0.4	-0.7	0.0	-0.4	0.4	-0.6
Reaction time mean minus median	0.1	0.4	0.7	-0.0	-0.6	-0.3	-0.9	0.8
Reaction time mean minus median AUC	0.0	0.1	0.2	-0.0	-0.1	0.1	-0.4	0.5
Reaction time num false alarms	0.8	1.3	4.1	-2.0	-1.1	-0.6	-0.6	0.7
Reaction time num false alarms AUC	0.6	1.4	3.7	-1.9	-1.2	-0.6	-0.8	1.0
Reaction time trials correct on left	0.1	0.2	0.4	-0.7	0.0	-0.4	0.4	-0.6
Reaction time trials on left	0.1	0.2	0.4	-0.7	-0.1	-0.5	0.2	-0.5
Reaction time mean	0.1	0.3	1.1	1.1	-0.1	0.2	-0.3	0.2
Reaction time mean AUC	0.1	0.4	1.6	1.3	-0.1	0.1	-0.4	0.3
Median of all reaction times	0.2	0.4	1.8	1.3	0.1	0.2	-0.1	0.0
Reaction time omissions	2.6	4.2	5.8	0.1	-2.4	-2.0	-2.3	2.4
Reaction time false alarm rate	0.4	0.5	1.1	-1.1	-0.6	0.1	-0.5	0.9
Reaction time premature initiation rate	0.3	0.5	0.9	-0.9	0.2	0.1	0.8	-1.0
Reaction time premature initiations	0.2	0.5	1.0	-1.0	0.1	-0.3	0.7	-1.0
Std. dev. reaction times	0.2	0.5	1.0	0.5	-0.6	-0.3	-0.9	1.0
Reaction time trials completed	0.1	0.2	0.4	-0.7	-0.1	-0.5	0.2	-0.5
Reaction time trials AUC	0.0	0.2	0.3	-0.5	0.0	-0.3	0.4	-0.6
Run reversals in cocaine runway, females	0.5	0.6	0.8	0.6	-0.8	-0.8	-0.9	0.8
Run reversals in cocaine runway, males	1.2	1.3	2.8	0.2	-0.8	-0.7	-1.7	1.6
Latency to leave start box in cocaine runway	0.2	0.3	0.4	0.3	0.6	0.7	0.7	-0.4
Latency to leave start box in cocaine runway, F	0.0	0.1	0.1	-0.3	0.3	0.3	0.2	0.1
Latency to leave start box in cocaine runway, M	0.8	0.7	1.1	1.0	0.8	0.8	0.9	-0.7
Std. dev. time between licks in bursts	0.5	0.8	3.3	-1.8	-0.5	-0.7	-0.3	-0.0
Total sessions with >9 infusions	1.0	1.3	2.1	-0.6	1.3	1.3	1.4	-0.9
Short access day 1 total inactive lever presses	0.2	0.4	0.6	-0.4	0.6	0.7	0.8	-0.6
Short access day 10 total inactive lever presses	0.1	0.4	1.2	1.1	0.4	0.7	0.5	-0.1
Short access day 1 total infusions	0.4	0.7	1.4	-0.0	0.9	0.9	1.2	-0.8
Short access day 10 total infusions	0.9	1.5	2.1	-1.2	1.2	1.3	1.4	-1.0
Short access total infusions	1.5	2.1	3.2	-1.0	1.5	1.4	1.8	-1.4
Short access day 1 locomotion	0.1	0.1	0.2	0.3	0.4	0.3	0.4	-0.0
Short access day 10 total locomotion	0.0	0.1	0.1	0.3	0.4	0.4	0.3	-0.2
Short access total locomotion	0.2	0.3	0.5	-0.3	0.7	0.7	0.7	-0.4
One hour access (0.3 mA shock)	2.1	2.5	3.4	1.3	1.8	1.7	1.7	-1.2
Compulsive drug intake	1.7	2.4	3.1	1.5	1.7	1.6	1.8	-1.1
One hour access (shock baseline)	0.3	0.7	1.1	0.4	1.0	0.9	0.8	-0.7
Social response proportion	1.1	1.4	2.3	-0.6	-1.5	-1.4	-1.1	1.1
Social responses	2.3	3.1	4.2	-0.4	-2.0	-1.7	-2.0	2.0
Social time	3.0	4.7	6.3	0.1	-2.5	-2.4	-2.4	2.3
Soleus weight	0.1	0.2	0.8	0.9	0.0	-0.4	-0.2	0.1
Bone: stiffness	1.6	2.9	12.0	3.5	1.2	0.9	0.4	0.1
Tibialis anterior weight	2.8	9.8	20.4	4.5	3.5	3.6	1.5	-1.0
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.3	0.5	-0.1	0.2	-0.4	0.2
Time to tail flick, vehicle, after self-admin	0.6	1.1	1.8	1.3	-0.8	-0.8	-1.1	1.1
Time to tail flick, test, before self-admin	1.2	1.4	2.5	-0.2	-1.2	-0.8	-1.6	1.5
Time to tail flick, test, after self-admin	1.2	1.3	3.5	1.9	-0.6	-0.4	-1.1	1.0
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.3	0.5	-0.2	-0.4	-0.0	0.2
Delta time to tail flick, test, before/after SA	0.4	0.5	2.3	1.5	0.1	0.2	0.1	-0.1
Tibia length	0.4	1.0	1.8	1.4	0.8	0.7	0.9	-1.1
Ambulatory time before self-admin	0.0	0.0	0.1	-0.2	0.1	0.0	0.1	-0.1
Ambulatory time after self-admin	0.9	1.4	3.0	-0.2	0.9	0.6	1.7	-1.7
Bone: tissue strength	1.4	1.4	2.2	0.9	1.5	1.3	1.1	-1.2
Total heroin consumption	1.3	1.6	2.0	1.4	1.3	1.0	1.2	-1.3
Bone: trabecular number	0.2	0.5	1.1	1.1	-0.5	-0.7	-0.5	0.4
Bone: trabecular spacing	2.2	3.2	4.2	-0.6	1.9	2.0	2.0	-1.9
Bone: trabecular thickness	0.3	0.4	0.6	0.5	-0.6	-0.5	-0.8	0.8
Bone: trabecular tissue density	0.2	0.3	0.6	0.4	0.4	0.8	0.1	0.6
Water consumed over 24 hours	0.3	0.5	1.4	-0.8	0.4	0.2	0.6	-1.2
Number of responses in last shaping day	3.9	5.0	6.5	-0.8	-2.5	-2.4	-2.5	2.3