Hub : Genes

Krt16

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	OFC	gene expression	Krt16	0.28	0.17	1.0e-03	0.17	0.08	0.15	0.14	7.3e-05	5.9e-03	2.1e-04	3.7e-04
2	PL	gene expression	Krt16	0.23	0.07	0.0e+00	0.23	0.23	0.22	0.23	1.1e-24	1.1e-24	4.4e-24	5.2e-25
3	BLA	gene expression	Krt16	0.46	0.14	1.1e-11	0.12	0.14	0.11	0.14	9.4e-07	7.3e-08	1.4e-06	9.9e-08
4	IC	gene expression	Krt16	0.28	0.1	5.6e-13	0.28	0.28	0.27	0.29	2.9e-12	3.1e-12	6.0e-12	1.8e-12

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.1	0.1	0.4	0.3	-0.1	-0.6	-0.3
Area under the delay curve	0.3	0.4	0.6	-0.8	0.7	0.5	0.6
BMI with tail	0.1	0.2	0.7	0.4	0.1	0.8	0.3
BMI without tail	0.5	2.7	4.1	-1.1	1.5	2.0	1.7
Body weight	1.7	7.6	10.7	-2.7	2.4	3.3	2.5
Weight adjusted by age	1.3	3.8	6.0	-1.9	2.4	1.1	2.1
Bone surface	0.5	1.1	1.8	-1.3	1.1	0.8	0.8
Bone volume	0.2	0.5	0.9	-0.9	0.7	0.5	0.4
Breakpoint value in progressive ratio session	0.2	0.3	0.6	0.8	-0.3	-0.6	-0.2
Number of licking bursts	0.8	2.5	3.1	1.7	-1.6	-1.2	-1.8
Context. condit. distance diff. score	1.7	2.0	2.4	-1.3	1.4	1.4	1.5
Locomotion velocity, session 1	0.1	0.1	0.2	-0.0	0.5	0.1	0.4
Locomotion distance, session 1	1.2	1.5	2.1	-1.1	1.3	1.5	1.2
Locomotion velocity, session 2	0.0	0.0	0.1	-0.2	-0.0	-0.1	0.0
Locomotion distance, session 2	0.0	0.1	0.1	-0.3	0.2	0.1	0.2
Locomotion velocity, session 3	0.3	0.3	0.5	-0.5	0.6	0.5	0.7
Locomotion distance, session 3	1.6	1.8	2.2	-1.4	1.5	1.2	1.4
Stereotopy head waving bouts, day 3	1.9	2.2	2.6	1.4	-1.5	-1.6	-1.5
Stereotopy head waving duration, day 3	0.2	0.3	0.3	0.4	-0.5	-0.5	-0.6
Locomotion velocity, session 7	0.3	0.4	1.1	-0.4	0.4	1.0	0.4
Locomotion distance, session 7	4.2	5.4	5.6	-2.4	2.3	2.4	2.2
Stereotopy head waving bouts, day 7	2.6	3.0	3.3	1.8	-1.8	-1.7	-1.7
Stereotopy head waving duration, day 7	3.6	4.5	4.7	2.2	-2.2	-2.1	-2.0
Locomotion velocity, session 8	1.2	1.4	2.0	-1.4	1.1	1.0	1.2
Locomotion distance, session 8	0.7	1.1	1.3	-1.1	1.0	1.0	1.1
Degree of sensitization distance	1.1	1.2	1.6	-1.3	0.9	1.2	0.9
Degree of sensitization stereotypy	2.2	2.4	2.6	1.6	-1.6	-1.6	-1.5
Conditioned locomotion	0.9	1.0	2.0	1.4	-0.9	-0.8	-0.8
Cocaine response after cond. corrected	0.4	0.6	0.9	0.8	-0.6	-0.9	-0.7
Cocaine response after cond. not corrected	0.1	0.2	0.3	0.3	-0.4	-0.6	-0.5
Cocaine response before conditioning	0.5	0.6	1.3	-1.1	0.6	0.7	0.4
Saline control response	1.0	1.4	2.6	-1.6	1.2	0.6	1.1
Bone: connectivity density	0.2	0.3	0.7	0.4	-0.3	-0.8	-0.4
Bone: cortical apparent density	2.2	3.5	4.8	1.9	-1.5	-2.2	-1.8
Bone: cortical area	0.3	0.4	0.9	-0.9	0.7	0.4	0.4
Bone: cortical porosity	0.5	0.5	0.8	-0.6	0.9	0.6	0.8
Bone: cortical porosity	0.6	0.7	0.9	-0.7	0.9	0.7	0.9
Bone: cortical thickness	0.2	0.4	0.6	0.5	-0.5	-0.7	-0.7
Bone: cortical thickness	0.3	0.4	1.1	0.3	-0.3	-1.0	-0.5
Bone: cortical tissue density	2.2	3.5	4.8	1.9	-1.6	-2.2	-1.8
Condit. Reinf. active minus inactive responses	0.2	0.2	0.8	0.2	-0.2	-0.9	-0.1
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.8	0.6	-0.5	-0.9	-0.4
Condit. Reinf. active responses	0.1	0.2	0.6	-0.0	-0.1	-0.8	-0.1
Condit. Reinf. inactive responses	0.1	0.2	0.3	-0.6	0.5	0.1	0.3
Incentive salience index mean	0.3	0.4	0.8	0.5	-0.5	-0.9	-0.4
Condit. Reinf. lever presses	0.1	0.1	0.1	0.4	-0.2	-0.3	-0.2
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	0.0	-0.4	-0.4	-0.3
Condit. Reinf. active-inactive response ratio	0.0	0.1	0.1	-0.3	0.2	0.2	0.3
Condit. Reinf. active responses	0.2	0.2	0.4	0.2	-0.5	-0.6	-0.5
Condit. Reinf. inactive responses	0.3	0.5	0.9	0.5	-0.5	-0.9	-0.7
Condit. Reinf. lever presses	0.1	0.2	0.3	-0.5	0.4	0.3	0.5
Condit. Reinf. lever reinforcers received	0.2	0.3	0.5	0.3	-0.5	-0.7	-0.5
Conditioned reinforcement - actives	0.4	1.4	2.2	-0.8	1.5	1.0	1.4
Conditioned reinforcement - inactives	0.0	0.0	0.0	0.1	0.1	-0.0	-0.1
Conditioned locomotion	1.2	1.8	2.9	-0.8	1.7	1.1	1.6
Patch foraging indifference point 0 sec	0.0	0.1	0.2	-0.5	0.3	0.2	0.2
Patch foraging indifference point AUC	0.2	0.4	0.7	0.9	-0.7	-0.4	-0.5
Delay disc. indifference point, 0s delay	0.1	0.2	0.3	-0.6	0.4	0.2	0.3
Delay disc. indifference point, 16s delay	0.0	0.0	0.1	0.1	-0.0	-0.3	0.1
Delay disc. indifference point, 2s delay	0.2	0.2	0.7	-0.8	0.2	0.1	0.1
Delay disc. indifference point, 24s delay	0.8	1.3	1.7	-1.1	1.3	0.9	1.2
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	-0.5	0.3	-0.1	0.3
Delay disc. indifference point, 8s delay	0.9	1.6	1.7	-1.3	1.3	1.3	1.2
Indifference point function ln k	0.1	0.2	0.4	-0.7	0.4	0.3	0.2
Indifference point function log k	0.1	0.2	0.4	-0.7	0.4	0.3	0.2
Patch foraging total patch changes 0 sec	0.1	0.3	0.5	-0.7	0.5	0.5	0.4
Patch foraging total patch changes 12 sec	0.4	0.5	0.7	0.6	-0.8	-0.8	-0.7
Patch foraging total patch changes 18 sec	0.0	0.1	0.3	-0.1	0.0	0.5	0.2
Patch foraging total patch changes 24 sec	0.0	0.0	0.1	0.1	0.1	0.2	0.2
Patch foraging total patch changes 6 sec	0.2	0.4	0.5	-0.7	0.6	0.5	0.7
Patch foraging time to switch 0 sec	0.1	0.2	0.4	-0.4	0.6	0.3	0.6
Patch foraging water rate 0 sec	0.0	0.0	0.0	-0.2	-0.1	0.1	-0.1
Patch foraging water rate 12 sec	0.0	0.0	0.1	0.2	-0.0	-0.1	-0.3
Patch foraging water rate 18 sec	0.4	0.9	1.6	0.5	-1.0	-0.8	-1.3
Patch foraging water rate 24 sec	0.0	0.0	0.1	0.2	0.1	0.3	-0.0
Patch foraging water rate 6 sec	1.0	1.5	1.7	1.0	-1.3	-1.3	-1.3
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.2	0.4	0.3	-0.2	0.4
Distance traveled before self-admin	0.3	0.7	1.1	-1.0	0.9	0.3	0.9
Distance traveled after self-admin	0.1	0.2	0.4	0.6	-0.7	-0.3	-0.3
Extensor digitorum longus weight	6.2	24.8	27.5	-5.1	4.7	5.2	4.9
Bone: elastic displacement	3.0	3.8	4.5	-1.7	2.1	1.8	2.1
Bone: elastic work	1.4	1.9	2.5	-1.1	1.6	1.2	1.5
Bone: endosteal estimation	3.9	9.4	11.4	-3.4	3.0	3.0	2.9
Bone: endosteal perimeter	1.3	3.3	4.7	-2.2	1.7	1.8	1.5
Epididymis fat weight	0.0	0.1	0.2	-0.5	0.1	0.5	0.1
Delta time in closed arm before/after self-admin	0.2	0.1	0.2	0.4	-0.5	-0.1	-0.4
Delta time in open arm before/after self-admin	0.1	0.1	0.1	-0.2	-0.3	-0.3	-0.3
Diff in mean of infusions in LGA sessions	0.2	0.3	0.5	0.0	0.7	0.5	0.7
Delay discount exponential model param	0.3	0.4	0.6	0.8	-0.7	-0.5	-0.7
Extinction: sum of active levers before priming	3.2	4.8	5.1	-2.1	2.3	2.1	2.3
Active lever presses in extinction session 6	0.1	0.1	0.1	0.1	0.3	-0.1	0.3
Bone: final force	0.1	0.1	0.3	-0.2	-0.3	-0.0	-0.5
Bone: final moment	0.1	0.1	0.3	-0.6	0.1	0.2	-0.2
Food consumed during 24 hour testing period	0.2	0.3	0.5	0.7	-0.7	-0.2	-0.5
Glucose	0.2	0.3	0.9	-0.0	0.3	1.0	0.4
Heart weight	0.3	0.5	1.1	-0.8	0.2	1.0	0.3
Delay discount hyperbolic model param	0.4	0.6	0.9	0.9	-0.8	-0.5	-0.7
Intermittent access intake day 1-15 change	1.0	5.7	6.7	2.5	-2.5	-1.9	-2.6
Intermittent access intake escalation	1.1	6.1	7.2	2.6	-2.5	-2.1	-2.7
Intermittent access intake escalation 2	1.5	2.4	3.5	1.6	-1.6	-1.1	-1.9
Intermitt. access day 1 inactive lever presses	0.1	1.1	1.2	1.0	-1.1	-0.9	-1.1
Intermitt. access day 15 inactive lever presses	0.0	0.3	0.5	-0.7	0.7	0.0	0.2
Intermitt. access escalation Index	0.0	0.1	0.2	-0.2	-0.3	-0.0	-0.4
Intermittent access day 1 total infusions	0.3	1.0	1.8	-1.4	0.9	0.5	1.0
Intermittent access day 15 total infusions	0.4	0.9	1.3	0.8	-0.9	-1.2	-1.0
Intermittent access terminal intake (last 3 days)	0.2	0.3	0.7	0.5	-0.4	-0.8	-0.5
Intermittent access total infusions	0.1	0.1	0.2	-0.0	0.0	-0.5	-0.0
Intermittent access day 1 locomotion	0.1	0.1	0.2	-0.5	0.3	0.2	0.3
Intermittent access day 15 total locomotion	0.1	0.2	0.4	0.6	-0.5	-0.3	-0.5
Intermittent access total locomotion	0.5	0.6	0.8	0.8	-0.7	-0.9	-0.7
Intermittent access standard deviation	0.2	1.0	1.3	1.0	-0.9	-1.2	-1.0
Left kidney weight	0.3	2.4	3.6	1.0	-1.9	-1.3	-1.8
Right kidney weight	0.3	2.4	3.6	0.9	-1.9	-1.4	-1.8
Cocaine induced anxiety	0.4	1.0	1.3	-1.1	1.1	0.9	0.9
Post-drug Anxiety	1.1	1.2	2.0	-1.0	1.4	0.9	1.1
Baseline Anxiety	0.2	0.3	0.7	-0.3	0.8	0.5	0.6
Tail length	1.2	6.4	7.6	-2.8	2.5	2.3	2.5
Length with tail	1.5	6.7	9.1	-3.0	2.3	2.7	2.2
Length without tail	0.2	1.2	2.5	-1.6	0.5	1.4	0.4
Times rat made contact with spout	0.0	0.0	0.1	0.3	-0.0	-0.1	-0.1
Lifetime Intake	0.1	0.2	0.3	-0.5	0.6	-0.2	0.4
Liver weight, left	0.5	0.8	1.7	-1.3	0.8	0.7	0.7
Liver weight, right	2.6	4.5	6.1	1.2	-2.5	-2.2	-2.4
Locomotor activity	1.3	2.1	2.9	1.7	-1.3	-1.4	-1.3
Locomotor testing distance	0.8	2.0	2.9	1.5	-1.2	-1.7	-1.2
Locomotor testing rearing	0.1	0.4	1.2	0.5	-0.4	-1.1	-0.2
Locomotion in novel chamber	0.2	0.3	1.2	-0.2	0.1	-1.1	0.2
Locomotion in novel chamber post-restriction	0.0	0.1	0.4	-0.6	0.2	-0.1	-0.0
Fecal boli incidents, locomotor time 1	0.2	0.6	1.0	0.6	-1.0	-0.6	-0.8
Change in fecal boli incidents, locomotor task	1.7	1.8	2.3	1.4	-1.5	-1.0	-1.5
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.6	0.5	-0.4	-0.8	-0.4
Bouts of movement, locomotor time 1	0.0	0.1	0.1	-0.1	0.1	0.3	0.3
Total resting periods, locomotor time 1	0.2	0.2	0.4	-0.3	0.3	0.7	0.6
Rest time, locomotor task time 1	0.1	0.1	0.3	-0.0	-0.2	0.6	0.1
Distance moved, locomotor task time 1	0.2	0.5	1.0	-0.7	1.0	-0.3	0.6
Vertical activity count, locomotor time 1	0.2	1.5	2.4	-1.4	1.5	0.8	1.1
Time >=10cm from walls, locomotor time 2	0.7	2.0	2.2	1.5	-1.5	-1.3	-1.4
Bouts of movement, locomotor time 2	0.3	0.9	1.6	-0.1	1.2	1.0	1.1
Total resting periods, locomotor time 2	0.3	1.3	2.2	-0.3	1.5	1.1	1.3
Rest time, locomotor task time 2	0.1	0.2	0.5	0.3	0.2	0.7	0.1
Distance moved, locomotor task time 2	0.6	0.8	1.3	-1.1	1.0	0.4	1.0
Vertical activity count, locomotor time 2	1.2	2.9	3.9	-2.0	1.8	1.3	1.7
Light reinforcement 1	0.1	0.3	0.5	0.5	-0.5	-0.7	-0.4
Light reinforcement 2	0.0	0.0	0.1	0.3	0.1	-0.2	0.1
Bone: marrow area	3.7	9.0	11.0	-3.3	3.0	2.9	2.8
Bone: maximum diameter	0.2	0.5	1.3	-1.1	0.7	0.3	0.4
Bone: maximum force	0.6	1.2	1.8	-1.4	1.1	1.1	0.8
Bone: maximum moment	1.2	2.2	3.1	-1.8	1.5	1.4	1.2
Mean time between licks in bursts	0.1	0.5	0.8	0.9	-0.8	0.3	-0.7
Mean num. licks in bursts	1.0	2.7	3.7	-1.6	1.8	1.2	1.9
Cd content in liver	2.0	2.2	2.7	-1.0	1.5	1.6	1.6
Co content in liver	0.3	0.4	0.5	-0.7	0.6	0.6	0.7
Cu content in liver	0.9	1.1	1.3	1.0	-1.0	-1.2	-1.1
Fe content in liver	0.2	0.2	0.4	-0.5	0.3	0.6	0.3
K content in liver	6.4	6.3	7.2	2.3	-2.5	-2.7	-2.6
Mg content in liver	5.0	5.5	7.4	2.1	-2.2	-2.7	-2.3
Mn content in liver	10.7	12.0	13.4	3.3	-3.5	-3.4	-3.7
Na content in liver	0.1	0.1	0.2	0.0	-0.1	-0.5	-0.3
Rb content in liver	1.6	1.9	2.9	1.1	-1.3	-1.7	-1.3
Se content in liver	10.1	12.0	13.1	3.5	-3.4	-3.6	-3.3
Sr content in liver	0.0	0.0	0.0	-0.1	-0.2	0.1	-0.1
Zn content in liver	0.9	1.1	2.2	1.0	-0.8	-1.5	-0.7
Bone: minimum diameter	1.2	2.4	2.7	-1.7	1.7	1.4	1.5
Time in familiar zone, hab. session 1	1.1	1.2	1.6	1.3	-1.2	-0.7	-1.1
Time in novel zone, hab. session 1	0.0	0.0	0.0	-0.1	0.1	-0.0	0.1
Total zone transitions, hab. session 1	1.6	2.2	3.0	-1.1	1.6	1.5	1.7
Total locomotion distance, hab. session 1	0.2	0.3	0.5	-0.3	0.6	0.5	0.7
Locomotion velocity, hab. session 1	0.4	0.6	1.0	-0.5	0.9	0.6	1.0
Time in familiar zone, hab. session 2	3.5	4.0	5.3	2.3	-1.9	-2.0	-1.8
Time in novel zone, hab. session 2	0.7	0.7	1.2	-1.1	0.7	0.8	0.7
Total zone transitions, hab. session 2	1.0	1.2	1.6	-1.0	1.1	1.3	1.0
Total locomotion distance, hab. session 2	0.1	0.1	0.2	-0.3	0.3	0.5	0.2
Locomotion velocity, hab. session 2	0.3	0.3	0.7	-0.5	0.5	0.8	0.5
Novel to familiar place preference ratio	0.8	1.1	1.7	-1.3	1.1	0.5	1.1
Novelty place preference	0.7	0.8	1.4	-1.2	0.9	0.4	0.9
Time in novel zone, NPP test	0.2	0.3	0.6	-0.8	0.5	-0.0	0.5
Total zone transitions, NPP test	2.1	3.0	3.5	-1.5	1.8	1.9	1.8
Total locomotion distance, NPP test	0.7	0.9	1.1	-0.8	1.0	1.1	0.9
Locomotion velocity, NPP test	1.9	2.7	2.9	-1.5	1.7	1.7	1.6
Intraocular pressure	2.8	4.6	5.5	-2.0	2.3	2.0	2.3
Delta distance traveled before/after self-admin	2.5	2.7	3.7	1.8	-1.9	-1.2	-1.6
Delta ambulatory time before/after self-admin	0.9	1.5	2.5	1.2	-1.6	-0.6	-1.3
Parametrial fat weight	0.0	0.1	0.2	0.1	0.4	0.5	0.2
Pavlov. Cond. lever latency	0.3	0.4	0.7	-0.6	0.5	0.8	0.7
Pavlov. Cond. magazine entry latency	3.0	3.9	5.2	2.1	-1.6	-2.3	-1.8
Pavlov. Cond. change in total contacts	3.1	3.3	4.7	1.7	-1.6	-2.2	-1.7
Pavlov. Cond. index score	1.4	1.7	2.7	1.3	-1.0	-1.6	-1.2
Pavlov. Cond. latency score	1.1	1.4	2.2	1.1	-0.9	-1.5	-1.2
Pavlov. Cond. lever contacts	0.4	0.5	0.7	0.8	-0.5	-0.9	-0.7
Pavlov. Cond. magazine entry number	3.3	4.2	6.4	-2.1	1.6	2.5	1.9
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.6	-0.8	0.5	0.5	0.6
Pavlov. Cond. lever-magazine prob. diff.	2.0	2.5	3.4	1.7	-1.2	-1.8	-1.5
Pavlov. Cond. response bias	1.7	2.1	3.3	1.6	-1.0	-1.8	-1.3
Pavlov. Cond. lever latency	0.1	0.1	0.2	-0.3	0.4	0.2	0.4
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	0.0	-0.0	0.2	-0.0
Pavlov. Cond. change in total contacts	0.1	0.2	0.3	0.2	-0.4	-0.4	-0.5
Pavlov. Cond. index score	0.0	0.0	0.1	0.1	-0.3	0.0	-0.2
Pavlov. Cond. latency score	0.0	0.0	0.0	-0.0	-0.2	0.1	-0.1
Pavlov. Cond. lever contacts	0.0	0.1	0.1	0.2	-0.3	-0.1	-0.3
Pavlov. Cond. magazine entry number	0.2	0.2	0.3	-0.6	0.5	0.3	0.5
Pavlov. Cond. intertrial magazine entries	0.1	0.3	0.4	-0.6	0.4	0.6	0.4
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.1	-0.0	-0.3	0.1	-0.3
Pavlov. Cond. response bias	0.3	0.5	0.6	0.6	-0.7	-0.6	-0.8
Time in closed arm before self-admin	1.0	1.7	2.0	1.4	-1.4	-1.2	-1.2
Time in closed arm after self-admin	2.5	2.9	4.0	2.0	-1.9	-1.1	-1.6
Time in open arm before self-admin	0.1	0.1	0.2	-0.5	0.2	0.5	0.2
Time in open arm after self-admin	0.4	0.5	1.3	-1.1	0.6	0.5	0.3
Bone: periosteal estimation	1.7	4.1	5.8	-2.4	2.1	1.8	1.8
Bone: periosteal perimeter	0.7	1.4	1.9	-1.4	1.1	1.2	1.0
Bone: post-yield work	1.0	1.7	2.4	-1.6	1.1	1.4	1.1
Progressive ratio test 1 active lever presses	0.2	0.3	0.6	-0.6	0.8	0.0	0.7
Progressive ratio test 1 breakpoint	0.2	0.3	0.5	-0.6	0.7	0.1	0.6
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.1	-0.3	0.2	0.1	0.3
Progressive ratio test 2 active lever presses	0.2	0.2	0.5	-0.4	0.7	-0.1	0.4
Progressive ratio test 2 breakpoint	0.1	0.2	0.4	-0.3	0.6	-0.1	0.4
Progressive ratio test 2 inactive lever presses	0.0	0.2	0.3	-0.3	0.6	0.1	0.4
Incentive Sensitization - Responses	0.2	0.5	0.8	-0.7	0.9	0.3	0.7
Incentive Sensitization - Breakpoint	0.2	0.5	0.9	-0.7	0.9	0.3	0.7
Sum of active levers in priming session hrs 5-6	0.2	0.1	0.3	0.4	-0.2	-0.6	-0.2
Progressive ratio	0.1	0.2	0.4	-0.5	0.6	-0.2	0.5
Food seeking constrained by brief footshock	0.0	0.0	0.0	0.0	-0.1	0.1	-0.2
Seeking ratio, punishment vs. effort	0.0	0.1	0.1	0.1	-0.3	0.4	-0.3
Retroperitoneal fat weight	0.0	0.1	0.6	-0.1	0.1	0.7	0.1
Reaction time number correct	0.1	0.2	0.6	-0.5	0.3	0.7	0.4
Reaction time mean minus median	0.1	0.5	0.8	-0.2	0.9	0.8	0.7
Reaction time mean minus median AUC	0.0	0.2	0.4	0.0	0.6	0.4	0.4
Reaction time num false alarms	1.2	2.1	2.9	1.7	-1.6	-0.9	-1.5
Reaction time num false alarms AUC	0.8	1.9	2.5	1.5	-1.6	-0.7	-1.5
Reaction time trials correct on left	0.1	0.2	0.6	-0.5	0.3	0.7	0.4
Reaction time trials on left	0.1	0.2	0.5	-0.4	0.2	0.7	0.3
Reaction time mean	0.5	1.1	1.9	0.8	-0.8	-1.4	-1.0
Reaction time mean AUC	0.2	0.5	1.2	0.5	-0.4	-1.1	-0.7
Median of all reaction times	1.5	2.3	4.0	1.0	-1.4	-2.0	-1.6
Reaction time omissions	0.2	0.3	0.5	0.7	-0.4	-0.6	-0.4
Reaction time false alarm rate	1.3	1.7	2.1	1.4	-1.4	-0.9	-1.5
Reaction time premature initiation rate	0.1	0.2	0.6	0.4	-0.3	-0.8	-0.2
Reaction time premature initiations	0.0	0.0	0.0	0.1	-0.1	-0.2	0.1
Std. dev. reaction times	0.1	0.2	0.5	0.7	-0.2	-0.3	-0.3
Reaction time trials completed	0.1	0.2	0.5	-0.4	0.2	0.7	0.3
Reaction time trials AUC	0.0	0.2	0.4	-0.4	0.1	0.7	0.2
Run reversals in cocaine runway, females	0.9	1.0	2.1	-1.4	0.7	0.5	1.0
Run reversals in cocaine runway, males	1.5	1.6	2.4	-1.5	1.5	0.5	1.3
Latency to leave start box in cocaine runway	0.1	0.1	0.3	-0.0	0.1	0.5	0.3
Latency to leave start box in cocaine runway, F	0.3	0.4	0.6	-0.7	0.4	0.8	0.7
Latency to leave start box in cocaine runway, M	0.2	0.2	0.7	0.8	-0.3	-0.3	-0.2
Std. dev. time between licks in bursts	0.0	0.1	0.2	0.1	-0.2	0.4	-0.2
Total sessions with >9 infusions	0.2	0.3	0.5	-0.4	0.7	0.2	0.7
Short access day 1 total inactive lever presses	0.3	0.6	1.4	-0.6	1.2	0.2	0.8
Short access day 10 total inactive lever presses	0.2	1.2	1.7	-1.0	1.3	0.9	1.1
Short access day 1 total infusions	0.1	0.3	0.5	-0.6	0.7	-0.3	0.5
Short access day 10 total infusions	0.2	0.4	0.6	-0.8	0.7	0.2	0.6
Short access total infusions	0.3	0.4	0.6	-0.7	0.8	0.0	0.7
Short access day 1 locomotion	0.3	0.5	0.8	-0.6	0.9	-0.0	0.8
Short access day 10 total locomotion	0.2	1.0	1.1	1.0	-1.1	-1.0	-1.0
Short access total locomotion	0.0	0.0	0.0	-0.0	0.2	-0.1	0.1
One hour access (0.3 mA shock)	1.3	1.5	2.5	-1.4	1.6	0.8	1.1
Compulsive drug intake	0.1	0.2	0.5	-0.7	0.3	0.2	0.2
One hour access (shock baseline)	0.2	0.5	0.9	-0.7	0.9	0.4	0.8
Social response proportion	0.1	0.1	0.4	-0.2	-0.1	0.7	0.1
Social responses	0.1	0.2	0.3	0.5	-0.5	-0.0	-0.3
Social time	0.9	1.4	1.7	-0.9	1.3	1.2	1.2
Soleus weight	0.1	0.2	0.6	-0.3	0.3	0.8	0.4
Bone: stiffness	0.0	0.0	0.1	-0.1	-0.2	0.0	-0.4
Tibialis anterior weight	1.0	3.4	3.5	-1.9	1.8	1.8	1.8
Time to tail flick, vehicle, before self-admin	0.3	0.4	0.7	-0.8	0.6	0.6	0.6
Time to tail flick, vehicle, after self-admin	1.9	3.9	5.1	-1.4	2.0	2.2	2.3
Time to tail flick, test, before self-admin	0.5	0.5	0.9	-0.9	0.6	0.7	0.7
Time to tail flick, test, after self-admin	0.3	0.4	0.7	0.2	-0.8	-0.4	-0.8
Delta time to tail flick, vehicle, before/after SA	0.8	0.9	1.3	-0.3	1.0	1.1	1.1
Delta time to tail flick, test, before/after SA	0.3	0.3	0.4	0.5	-0.6	-0.6	-0.6
Tibia length	0.0	0.1	0.3	-0.4	-0.1	0.5	-0.1
Ambulatory time before self-admin	0.5	1.6	2.1	-1.4	1.4	0.8	1.4
Ambulatory time after self-admin	0.0	0.0	0.1	-0.2	-0.2	0.3	0.1
Bone: tissue strength	0.6	0.6	1.5	-0.7	0.4	1.2	0.4
Total heroin consumption	1.2	1.5	1.7	1.3	-1.2	-1.1	-1.2
Bone: trabecular number	0.7	1.3	2.1	1.2	-0.8	-1.4	-1.0
Bone: trabecular spacing	0.5	0.8	0.9	-0.9	0.8	0.9	0.8
Bone: trabecular thickness	0.0	0.1	0.1	0.3	-0.3	0.1	-0.3
Bone: trabecular tissue density	0.0	0.0	0.0	-0.2	-0.2	0.1	-0.2
Water consumed over 24 hours	0.9	1.8	2.6	1.2	-1.6	-0.9	-1.6
Number of responses in last shaping day	0.0	0.0	0.1	0.3	0.0	-0.0	-0.2