Hub : Genes

Krt16

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	Krt16	0.38	0.13	1.4e-11	0.11	0.14	0.16	0.16	1.7e-06	3.6e-08	3.9e-09	5.4e-09
2	PL	gene expression	Krt16	0.19	0.06	0.0e+00	0.22	0.2	0.21	0.22	3.3e-23	3.7e-21	3.4e-23	4.7e-24
3	OFC	gene expression	Krt16	0.22	0.13	2.3e-03	0.08	0.06	0.12	0.02	5.2e-03	1.9e-02	8.9e-04	9.0e-02
4	PL	alternative polyA	NM_001008752.2	0.1	0.04	2.9e-10	0.07	0.09	0.07	0.08	8.2e-08	3.8e-10	1.0e-07	5.0e-09
5	BLA	alternative polyA	NM_001008752.2	0.08	0.05	7.4e-03	-0	0	0	-0	5.8e-01	1.8e-01	1.8e-01	6.4e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	0.5	0.8	2.0	1.4	-0.4	0.6	-0.9	-0.7
Area under the delay curve	1.2	1.3	2.4	-0.6	0.9	-1.3	1.0	1.6
BMI with tail	0.2	0.5	0.9	-0.8	-0.6	0.6	-0.4	-1.0
BMI without tail	0.1	0.2	0.4	-0.5	0.3	0.0	0.7	0.1
Body weight	0.6	2.3	7.8	-2.8	0.7	-1.4	1.1	0.5
Weight adjusted by age	3.5	3.9	6.0	-0.7	2.4	-1.9	2.2	2.1
Bone surface	0.2	0.3	0.8	-0.4	0.8	-0.9	0.2	-0.0
Bone volume	0.1	0.2	0.5	-0.1	0.4	-0.1	-0.4	-0.7
Breakpoint value in progressive ratio session	0.7	0.8	1.7	1.3	-0.9	0.9	-0.6	-0.6
Number of licking bursts	2.6	3.0	3.9	1.1	-1.7	2.0	-1.9	-2.0
Context. condit. distance diff. score	2.6	3.1	5.4	-1.2	1.4	-1.8	1.9	2.3
Locomotion velocity, session 1	0.1	0.1	0.2	0.0	0.4	-0.1	0.2	-0.1
Locomotion distance, session 1	0.9	1.1	2.1	-1.5	1.1	-1.1	0.9	0.6
Locomotion velocity, session 2	0.1	0.1	0.3	0.2	0.1	-0.3	0.5	0.5
Locomotion distance, session 2	0.0	0.0	0.0	-0.0	0.1	-0.1	0.2	0.2
Locomotion velocity, session 3	0.5	0.5	1.1	-0.2	0.4	-0.8	0.9	1.1
Locomotion distance, session 3	1.3	1.4	1.9	-0.9	1.2	-1.4	1.2	1.2
Stereotopy head waving bouts, day 3	1.5	1.7	3.5	1.9	-1.5	1.0	-1.1	-0.7
Stereotopy head waving duration, day 3	0.1	0.2	0.4	0.6	-0.4	0.4	-0.4	-0.2
Locomotion velocity, session 7	0.3	0.4	1.6	-1.2	0.5	0.0	0.3	-0.2
Locomotion distance, session 7	3.2	4.1	5.5	-2.3	2.3	-1.6	2.0	1.7
Stereotopy head waving bouts, day 7	1.9	2.2	3.1	1.6	-1.8	1.2	-1.5	-1.2
Stereotopy head waving duration, day 7	2.8	3.4	4.6	2.1	-2.1	1.5	-1.9	-1.5
Locomotion velocity, session 8	1.3	1.6	2.3	-1.2	1.0	-1.2	1.2	1.5
Locomotion distance, session 8	0.8	1.2	2.0	-0.7	0.9	-1.2	1.2	1.4
Degree of sensitization distance	1.5	1.5	2.4	-1.5	1.2	-1.0	1.3	1.0
Degree of sensitization stereotypy	1.7	1.9	2.5	1.6	-1.6	1.1	-1.5	-1.1
Conditioned locomotion	0.5	0.6	1.1	1.1	-0.9	1.0	-0.4	-0.2
Cocaine response after cond. corrected	0.3	0.3	1.1	1.0	-0.4	0.5	-0.3	-0.3
Cocaine response after cond. not corrected	0.0	0.1	0.2	0.4	-0.3	-0.0	-0.1	-0.1
Cocaine response before conditioning	0.5	0.7	1.6	-1.3	0.4	-1.0	0.5	0.4
Saline control response	0.6	0.8	1.4	-0.8	0.8	-1.2	0.8	0.9
Bone: connectivity density	0.7	1.0	3.2	1.8	-0.6	0.7	-0.9	-0.6
Bone: cortical apparent density	2.7	3.6	4.9	2.1	-1.4	2.1	-2.2	-1.5
Bone: cortical area	0.2	0.3	0.9	-0.5	0.4	-1.0	0.3	0.1
Bone: cortical porosity	0.1	0.1	0.4	-0.1	0.7	-0.4	0.2	-0.1
Bone: cortical porosity	0.1	0.1	0.3	-0.0	0.6	-0.4	0.3	0.1
Bone: cortical thickness	0.2	0.4	0.9	0.9	-0.9	-0.2	-0.4	0.0
Bone: cortical thickness	0.7	0.8	3.0	1.7	-0.8	-0.2	-0.0	0.7
Bone: cortical tissue density	2.9	3.8	5.1	2.1	-1.5	2.1	-2.3	-1.6
Condit. Reinf. active minus inactive responses	0.3	0.4	1.6	1.3	-0.2	0.1	-0.0	0.5
Condit. Reinf. active-inactive response ratio	0.4	0.5	1.8	1.3	-0.5	0.1	0.1	0.5
Condit. Reinf. active responses	0.3	0.4	1.6	1.3	-0.1	0.1	-0.1	0.5
Condit. Reinf. inactive responses	0.1	0.1	0.2	0.3	0.5	-0.2	-0.1	0.2
Incentive salience index mean	0.3	0.4	1.4	1.2	-0.5	0.3	-0.2	0.3
Condit. Reinf. lever presses	0.0	0.0	0.1	0.3	-0.0	0.0	-0.1	0.2
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	0.4	-0.2	0.3	-0.3	-0.5
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.2	-0.4	0.4	-0.5	0.5	0.3
Condit. Reinf. active responses	0.4	0.5	0.9	0.7	-0.3	0.7	-0.7	-1.0
Condit. Reinf. inactive responses	1.1	1.3	1.8	1.2	-0.6	1.1	-1.3	-1.3
Condit. Reinf. lever presses	0.2	0.2	0.4	0.1	0.7	-0.6	0.5	0.5
Condit. Reinf. lever reinforcers received	0.3	0.5	0.8	0.9	-0.3	0.7	-0.7	-0.8
Conditioned reinforcement - actives	0.4	0.4	0.8	-0.4	0.9	-0.5	0.6	0.4
Conditioned reinforcement - inactives	0.6	0.7	1.3	0.3	-0.5	0.9	-1.0	-1.2
Conditioned locomotion	0.9	1.0	2.3	-0.3	1.5	-0.9	1.2	0.6
Patch foraging indifference point 0 sec	0.5	0.8	1.3	-0.2	0.7	-1.2	1.1	1.0
Patch foraging indifference point AUC	0.3	0.3	0.8	0.1	-0.9	0.4	-0.5	-0.7
Delay disc. indifference point, 0s delay	0.2	0.2	0.5	-0.3	0.6	-0.7	0.2	0.5
Delay disc. indifference point, 16s delay	0.9	0.9	2.8	0.3	0.1	-1.1	0.7	1.7
Delay disc. indifference point, 2s delay	0.1	0.2	0.6	-0.3	0.3	-0.8	0.1	-0.1
Delay disc. indifference point, 24s delay	2.8	2.7	4.7	-1.0	1.6	-1.5	1.8	2.2
Delay disc. indifference point, 4s delay	0.4	0.4	1.0	0.2	0.3	-0.9	0.4	1.0
Delay disc. indifference point, 8s delay	1.6	1.6	2.6	-1.4	1.6	-1.1	1.0	1.2
Indifference point function ln k	0.4	0.5	1.2	-0.4	0.7	-0.6	0.7	1.1
Indifference point function log k	0.4	0.5	1.2	-0.4	0.7	-0.6	0.7	1.1
Patch foraging total patch changes 0 sec	0.5	0.9	1.6	-0.4	0.7	-1.3	1.1	0.9
Patch foraging total patch changes 12 sec	0.9	1.2	1.7	1.3	-1.3	0.5	-0.9	-1.2
Patch foraging total patch changes 18 sec	0.1	0.1	0.2	-0.1	-0.3	-0.0	0.0	-0.5
Patch foraging total patch changes 24 sec	0.1	0.1	0.3	0.5	-0.3	-0.1	-0.2	-0.1
Patch foraging total patch changes 6 sec	0.4	0.6	1.1	-0.3	0.3	-1.0	1.1	0.9
Patch foraging time to switch 0 sec	0.1	0.1	0.2	0.4	0.3	0.1	0.3	0.2
Patch foraging water rate 0 sec	0.1	0.2	0.3	-0.5	0.3	-0.5	0.2	0.3
Patch foraging water rate 12 sec	0.0	0.0	0.1	0.1	-0.0	0.1	-0.2	-0.3
Patch foraging water rate 18 sec	0.4	0.5	1.0	0.5	-1.0	0.2	-1.0	-0.5
Patch foraging water rate 24 sec	0.0	0.0	0.1	-0.3	-0.0	-0.1	-0.0	-0.1
Patch foraging water rate 6 sec	0.7	1.1	1.5	1.2	-1.2	0.9	-1.1	-0.7
Seeking ratio, delayed vs. immediate footshock	0.2	0.3	0.8	0.6	-0.1	0.3	0.2	0.9
Distance traveled before self-admin	2.8	3.0	3.9	-0.9	1.9	-2.0	1.9	1.8
Distance traveled after self-admin	0.0	0.0	0.1	-0.1	-0.2	0.3	0.1	-0.0
Extensor digitorum longus weight	5.5	21.6	29.0	-5.4	5.0	-4.5	4.5	3.7
Bone: elastic displacement	1.3	1.5	2.9	-1.0	1.7	-1.1	1.3	0.8
Bone: elastic work	0.5	0.6	1.4	-0.1	1.2	-0.8	0.8	0.6
Bone: endosteal estimation	2.6	5.6	9.7	-3.1	2.9	-2.1	2.0	1.0
Bone: endosteal perimeter	0.7	1.5	3.0	-1.7	1.6	-1.0	0.9	0.1
Epididymis fat weight	0.1	0.3	1.2	-1.1	-0.0	-0.3	0.2	-0.3
Delta time in closed arm before/after self-admin	0.2	0.2	0.6	0.0	-0.1	0.8	-0.4	-0.2
Delta time in open arm before/after self-admin	0.2	0.2	0.5	-0.7	-0.5	-0.4	-0.3	-0.3
Diff in mean of infusions in LGA sessions	0.2	0.3	0.8	-0.1	0.9	-0.1	0.7	0.4
Delay discount exponential model param	1.3	1.4	2.9	0.6	-0.9	1.4	-1.1	-1.7
Extinction: sum of active levers before priming	1.6	1.6	2.6	-1.6	1.4	-1.1	1.2	0.7
Active lever presses in extinction session 6	0.6	0.6	1.5	1.2	-0.3	0.5	-0.7	-0.9
Bone: final force	0.1	0.1	0.3	-0.3	-0.3	-0.3	-0.4	-0.5
Bone: final moment	0.1	0.1	0.3	-0.4	0.0	-0.5	-0.2	-0.3
Food consumed during 24 hour testing period	0.2	0.2	0.5	0.0	-0.5	0.7	-0.5	-0.4
Glucose	0.5	0.7	1.5	0.2	-0.5	1.0	-0.8	-1.2
Heart weight	0.8	1.2	3.5	-1.9	0.5	-0.7	1.1	0.7
Delay discount hyperbolic model param	1.3	1.4	2.6	0.6	-0.9	1.4	-1.1	-1.6
Intermittent access intake day 1-15 change	5.2	5.1	8.3	1.3	-1.7	2.3	-2.9	-2.7
Intermittent access intake escalation	6.9	6.7	9.9	1.7	-2.3	2.7	-3.1	-2.9
Intermittent access intake escalation 2	4.7	4.6	6.8	1.3	-1.9	2.2	-2.6	-2.5
Intermitt. access day 1 inactive lever presses	1.0	1.0	1.8	1.3	-0.8	0.9	-1.3	-0.6
Intermitt. access day 15 inactive lever presses	0.9	1.0	2.2	1.1	-0.5	0.6	-1.5	-1.1
Intermitt. access escalation Index	0.3	0.3	0.6	-0.5	0.1	-0.7	0.4	0.6
Intermittent access day 1 total infusions	1.2	1.4	2.2	-0.8	1.1	-1.5	1.2	1.3
Intermittent access day 15 total infusions	0.6	0.7	1.3	0.9	-0.7	0.7	-1.1	-0.7
Intermittent access terminal intake (last 3 days)	0.3	0.4	0.8	0.7	-0.3	0.6	-0.9	-0.5
Intermittent access total infusions	0.1	0.1	0.2	0.1	0.4	-0.4	0.1	0.5
Intermittent access day 1 locomotion	0.7	0.7	1.3	-0.8	1.2	-1.1	0.6	0.1
Intermittent access day 15 total locomotion	1.0	1.0	3.2	0.1	-0.2	0.7	-1.2	-1.8
Intermittent access total locomotion	0.5	0.6	1.5	0.6	-0.2	0.5	-0.8	-1.2
Intermittent access standard deviation	2.4	2.6	3.8	1.7	-1.0	1.6	-1.9	-1.6
Left kidney weight	0.3	0.8	3.3	0.7	-1.8	0.2	-0.2	0.4
Right kidney weight	0.7	1.9	5.1	1.3	-2.3	1.2	-0.9	-0.6
Cocaine induced anxiety	0.4	0.4	1.5	-0.2	0.2	-0.4	0.6	1.2
Post-drug Anxiety	0.4	0.5	1.6	-0.2	0.2	-0.5	0.5	1.3
Baseline Anxiety	0.3	0.3	0.9	-0.2	0.9	-0.6	0.3	0.1
Tail length	1.2	3.7	5.0	-1.4	1.5	-2.2	2.1	2.1
Length with tail	1.6	5.9	8.6	-2.7	1.8	-2.9	2.2	2.4
Length without tail	0.6	1.2	3.0	-1.7	0.6	-1.5	0.4	0.6
Times rat made contact with spout	0.3	0.3	0.6	-0.1	-0.2	0.7	-0.6	-0.8
Lifetime Intake	0.5	0.6	1.1	-0.2	0.8	-0.8	0.6	1.0
Liver weight, left	0.1	0.1	0.4	0.0	0.6	-0.1	0.4	0.5
Liver weight, right	1.1	1.8	3.5	1.7	-1.9	1.0	-1.0	-0.7
Locomotor activity	1.5	2.4	3.8	1.9	-1.4	1.6	-1.2	-1.5
Locomotor testing distance	1.6	2.7	5.8	2.4	-1.2	1.7	-1.3	-1.3
Locomotor testing rearing	0.7	1.1	4.8	2.2	-0.5	0.7	-0.4	-0.2
Locomotion in novel chamber	0.7	0.9	3.3	1.8	-0.4	0.3	0.3	0.9
Locomotion in novel chamber post-restriction	0.3	0.4	0.7	0.5	0.2	0.7	-0.6	-0.9
Fecal boli incidents, locomotor time 1	1.4	1.5	2.6	0.3	-1.2	1.5	-1.1	-1.6
Change in fecal boli incidents, locomotor task	0.5	0.4	0.9	0.9	-0.9	0.6	-0.4	-0.1
Time >=10cm from walls, locomotor time 1	0.5	0.5	1.1	0.8	-0.7	1.0	-0.6	-0.3
Bouts of movement, locomotor time 1	0.1	0.1	0.3	-0.5	0.4	-0.2	0.0	0.2
Total resting periods, locomotor time 1	0.3	0.4	1.0	-1.0	0.6	-0.5	0.4	0.2
Rest time, locomotor task time 1	0.3	0.4	1.0	-0.8	-0.0	0.1	-0.4	-1.0
Distance moved, locomotor task time 1	0.6	0.7	1.9	0.8	0.4	-0.5	0.6	1.4
Vertical activity count, locomotor time 1	0.5	0.6	1.0	-0.1	1.0	-0.8	0.6	0.9
Time >=10cm from walls, locomotor time 2	2.3	2.5	3.0	1.6	-1.3	1.7	-1.6	-1.5
Bouts of movement, locomotor time 2	1.1	1.2	1.8	-0.2	1.3	-1.3	1.0	1.4
Total resting periods, locomotor time 2	1.5	1.6	2.6	-0.4	1.4	-1.4	1.2	1.6
Rest time, locomotor task time 2	0.2	0.3	1.2	-1.1	0.2	0.2	-0.0	-0.2
Distance moved, locomotor task time 2	0.6	0.7	1.2	-0.1	0.7	-1.1	0.9	1.1
Vertical activity count, locomotor time 2	1.5	1.6	2.6	-0.7	1.4	-1.6	1.3	1.3
Light reinforcement 1	0.3	0.5	1.2	1.1	-0.9	0.2	-0.6	-0.4
Light reinforcement 2	0.1	0.1	0.3	0.4	0.0	-0.5	0.1	0.3
Bone: marrow area	2.4	5.2	9.1	-3.0	2.8	-2.0	2.0	1.0
Bone: maximum diameter	0.1	0.2	0.5	-0.4	0.4	-0.7	0.2	-0.1
Bone: maximum force	0.5	0.9	1.5	-1.2	1.1	-1.1	0.6	0.2
Bone: maximum moment	0.8	1.4	2.0	-1.4	1.4	-1.4	0.9	0.5
Mean time between licks in bursts	1.3	1.8	3.3	-0.2	-1.0	1.7	-1.2	-1.8
Mean num. licks in bursts	1.9	2.3	2.9	-1.0	1.7	-1.4	1.6	1.6
Cd content in liver	0.1	0.2	0.3	-0.2	0.4	-0.1	0.5	0.6
Co content in liver	0.2	0.2	0.7	-0.3	-0.0	-0.2	0.6	0.8
Cu content in liver	0.2	0.2	0.7	0.1	-0.2	-0.5	0.4	0.8
Fe content in liver	0.1	0.1	0.2	-0.4	-0.1	-0.5	0.2	0.5
K content in liver	5.0	4.9	7.7	2.3	-2.8	1.9	-2.2	-1.8
Mg content in liver	4.2	4.3	7.0	2.6	-2.6	1.6	-2.0	-1.3
Mn content in liver	11.8	13.4	17.2	3.6	-4.1	3.6	-3.8	-3.1
Na content in liver	1.1	1.1	2.0	0.6	-0.2	1.1	-1.4	-1.4
Rb content in liver	1.7	2.1	3.6	1.9	-1.8	1.3	-1.1	-0.8
Se content in liver	5.0	6.1	10.5	3.2	-3.0	2.0	-2.1	-1.5
Sr content in liver	0.1	0.1	0.2	0.3	-0.5	0.2	0.2	0.1
Zn content in liver	0.4	0.4	0.8	0.9	-0.8	0.6	-0.4	-0.1
Bone: minimum diameter	0.5	1.0	1.7	-1.1	1.3	-1.0	0.9	0.4
Time in familiar zone, hab. session 1	2.4	2.2	4.4	1.2	-1.1	2.1	-1.5	-1.3
Time in novel zone, hab. session 1	0.2	0.1	0.3	-0.4	0.2	-0.5	0.5	0.2
Total zone transitions, hab. session 1	1.8	2.5	4.2	-1.3	1.7	-0.9	1.8	2.0
Total locomotion distance, hab. session 1	0.4	0.5	1.5	-0.0	0.6	-0.2	0.7	1.2
Locomotion velocity, hab. session 1	0.5	0.8	2.1	0.0	0.8	-0.4	0.9	1.4
Time in familiar zone, hab. session 2	3.6	3.7	4.5	2.1	-2.1	2.1	-1.9	-1.3
Time in novel zone, hab. session 2	0.7	0.7	1.1	-0.9	1.0	-0.7	1.0	0.4
Total zone transitions, hab. session 2	1.0	1.3	2.1	-1.5	1.2	-0.8	1.2	1.0
Total locomotion distance, hab. session 2	0.1	0.1	0.3	-0.6	0.3	-0.0	0.2	0.0
Locomotion velocity, hab. session 2	0.2	0.2	0.6	-0.8	0.5	-0.2	0.4	0.3
Novel to familiar place preference ratio	1.4	1.5	2.4	-0.2	1.0	-1.5	1.3	1.5
Novelty place preference	1.4	1.4	2.3	-0.2	0.8	-1.5	1.3	1.5
Time in novel zone, NPP test	0.7	0.7	1.3	0.2	0.4	-1.1	0.9	1.1
Total zone transitions, NPP test	1.7	2.4	4.0	-2.0	1.6	-1.4	1.5	1.1
Total locomotion distance, NPP test	0.4	0.5	0.9	-0.9	0.8	-0.5	0.7	0.4
Locomotion velocity, NPP test	1.3	1.9	2.4	-1.6	1.5	-1.3	1.3	1.1
Intraocular pressure	4.4	6.1	7.7	-2.4	2.1	-2.5	2.8	2.5
Delta distance traveled before/after self-admin	3.9	4.2	6.2	1.2	-2.4	2.5	-2.0	-1.9
Delta ambulatory time before/after self-admin	3.4	3.8	5.1	0.8	-2.3	2.3	-1.9	-2.0
Parametrial fat weight	0.0	0.0	0.1	0.4	0.1	-0.1	-0.0	-0.1
Pavlov. Cond. lever latency	0.3	0.4	0.9	-0.9	0.6	-0.3	0.6	0.1
Pavlov. Cond. magazine entry latency	3.7	4.8	8.0	2.8	-2.0	2.1	-2.2	-1.6
Pavlov. Cond. change in total contacts	1.7	1.8	4.7	2.2	-1.6	0.8	-1.0	-0.0
Pavlov. Cond. index score	1.4	1.7	3.3	1.8	-1.1	1.2	-1.5	-0.8
Pavlov. Cond. latency score	1.2	1.5	2.5	1.6	-1.1	1.1	-1.4	-0.8
Pavlov. Cond. lever contacts	0.2	0.2	0.5	0.7	-0.4	0.4	-0.6	-0.2
Pavlov. Cond. magazine entry number	3.5	4.3	8.5	-2.9	1.8	-2.0	2.1	1.2
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.4	-0.5	0.6	-0.4	0.5	0.5
Pavlov. Cond. lever-magazine prob. diff.	1.7	2.1	3.7	1.9	-1.4	1.3	-1.5	-0.9
Pavlov. Cond. response bias	1.2	1.4	4.2	2.0	-1.0	0.8	-1.0	-0.2
Pavlov. Cond. lever latency	0.1	0.2	0.4	-0.4	0.1	-0.4	0.4	0.6
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	-0.5	0.4	-0.0	0.3	0.1
Pavlov. Cond. change in total contacts	0.2	0.3	0.6	0.3	-0.1	0.7	-0.6	-0.8
Pavlov. Cond. index score	0.1	0.1	0.4	-0.0	0.0	0.4	-0.3	-0.6
Pavlov. Cond. latency score	0.1	0.1	0.3	-0.1	0.1	0.3	-0.2	-0.6
Pavlov. Cond. lever contacts	0.3	0.4	0.6	0.5	-0.3	0.7	-0.6	-0.8
Pavlov. Cond. magazine entry number	0.1	0.1	0.3	-0.0	0.0	-0.6	0.3	0.4
Pavlov. Cond. intertrial magazine entries	0.7	1.0	1.6	-1.1	0.1	-1.1	0.8	1.3
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.3	-0.2	0.0	0.3	-0.2	-0.5
Pavlov. Cond. response bias	0.3	0.4	0.7	0.7	-0.5	0.8	-0.6	-0.7
Time in closed arm before self-admin	1.3	1.4	2.5	1.6	-1.5	0.8	-0.9	-1.0
Time in closed arm after self-admin	1.6	1.7	2.9	1.7	-1.4	1.4	-0.9	-0.8
Time in open arm before self-admin	0.3	0.3	0.4	-0.5	0.6	-0.3	0.5	0.6
Time in open arm after self-admin	0.8	0.9	2.4	-1.6	0.8	-1.0	0.5	0.4
Bone: periosteal estimation	1.0	2.1	3.2	-1.8	1.8	-1.6	1.2	0.6
Bone: periosteal perimeter	0.3	0.5	1.0	-1.0	0.9	-0.7	0.5	-0.2
Bone: post-yield work	1.1	1.5	2.8	-1.7	1.1	-1.1	1.2	1.0
Progressive ratio test 1 active lever presses	0.3	0.3	0.4	-0.1	0.7	-0.6	0.4	0.6
Progressive ratio test 1 breakpoint	0.2	0.2	0.3	-0.0	0.6	-0.5	0.3	0.5
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.1	0.3	-0.1	-0.1	-0.1	0.3
Progressive ratio test 2 active lever presses	0.1	0.1	0.4	-0.2	0.6	-0.4	-0.2	-0.1
Progressive ratio test 2 breakpoint	0.2	0.2	0.7	-0.4	0.9	-0.5	-0.2	-0.1
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.2	0.1	0.4	0.0	-0.5	-0.2
Incentive Sensitization - Responses	0.6	0.6	1.8	-0.7	1.3	-0.7	-0.0	-0.3
Incentive Sensitization - Breakpoint	0.5	0.5	1.8	-0.6	1.3	-0.5	-0.2	-0.5
Sum of active levers in priming session hrs 5-6	1.2	1.1	2.2	1.5	-1.1	1.0	-0.9	-0.7
Progressive ratio	0.1	0.1	0.3	0.6	-0.1	0.1	-0.3	-0.2
Food seeking constrained by brief footshock	0.0	0.0	0.1	0.1	-0.1	-0.2	-0.3	-0.2
Seeking ratio, punishment vs. effort	0.1	0.1	0.3	-0.6	-0.0	-0.2	-0.0	-0.1
Retroperitoneal fat weight	0.0	0.2	0.3	-0.6	-0.1	-0.5	0.4	0.1
Reaction time number correct	0.1	0.2	0.9	-0.9	0.1	-0.1	0.1	-0.0
Reaction time mean minus median	0.5	0.6	1.6	-1.1	1.2	-0.2	0.6	0.2
Reaction time mean minus median AUC	0.3	0.4	1.3	-0.7	1.1	0.0	0.4	0.2
Reaction time num false alarms	1.9	2.6	4.2	0.6	-1.5	1.9	-1.7	-2.1
Reaction time num false alarms AUC	1.8	2.4	4.7	0.2	-1.3	1.7	-1.7	-2.2
Reaction time trials correct on left	0.1	0.2	0.9	-0.9	0.1	-0.1	0.1	-0.0
Reaction time trials on left	0.1	0.2	0.8	-0.9	0.1	0.0	0.1	-0.1
Reaction time mean	0.4	0.5	1.2	1.1	-0.6	0.6	-0.6	-0.4
Reaction time mean AUC	0.1	0.2	0.7	0.8	-0.2	0.2	-0.3	-0.1
Median of all reaction times	1.0	1.4	3.1	1.8	-1.3	0.9	-1.1	-0.7
Reaction time omissions	0.8	1.0	1.5	1.2	-0.9	1.0	-1.0	-0.9
Reaction time false alarm rate	1.4	2.0	3.6	0.6	-1.2	1.4	-1.5	-1.9
Reaction time premature initiation rate	0.3	0.4	1.4	1.2	-0.7	-0.0	-0.0	0.4
Reaction time premature initiations	0.1	0.1	0.2	0.4	-0.4	-0.1	0.2	0.4
Std. dev. reaction times	0.1	0.2	0.4	0.0	0.2	0.6	-0.3	-0.6
Reaction time trials completed	0.1	0.2	0.8	-0.9	0.1	0.0	0.1	-0.1
Reaction time trials AUC	0.1	0.2	0.7	-0.8	-0.1	0.1	-0.1	-0.2
Run reversals in cocaine runway, females	3.7	3.6	7.2	-0.4	1.4	-2.2	2.0	2.7
Run reversals in cocaine runway, males	1.3	1.3	2.3	-0.0	1.3	-1.1	1.1	1.5
Latency to leave start box in cocaine runway	0.0	0.0	0.1	-0.2	0.3	0.1	0.0	0.0
Latency to leave start box in cocaine runway, F	0.3	0.4	0.7	-0.4	0.5	-0.8	0.6	0.6
Latency to leave start box in cocaine runway, M	0.3	0.3	0.8	0.8	0.0	0.9	-0.3	-0.1
Std. dev. time between licks in bursts	0.3	0.3	1.0	-0.0	-0.2	0.4	-0.5	-1.0
Total sessions with >9 infusions	0.6	0.7	1.0	-0.3	0.9	-0.9	0.8	1.0
Short access day 1 total inactive lever presses	0.2	0.2	0.5	0.2	0.5	-0.2	0.3	0.7
Short access day 10 total inactive lever presses	1.0	1.1	1.6	-0.3	1.2	-1.1	1.1	1.3
Short access day 1 total infusions	0.8	0.9	2.4	0.2	0.4	-1.1	0.9	1.5
Short access day 10 total infusions	1.3	1.5	2.9	-0.9	1.7	-1.2	1.1	1.1
Short access total infusions	1.2	1.4	2.9	-0.1	1.1	-1.2	1.1	1.7
Short access day 1 locomotion	0.4	0.4	0.6	0.7	0.5	-0.7	0.6	0.8
Short access day 10 total locomotion	0.7	0.8	2.6	0.4	0.2	0.5	-0.9	-1.6
Short access total locomotion	0.3	0.4	0.9	-0.3	0.9	-0.8	0.4	0.2
One hour access (0.3 mA shock)	0.4	0.5	1.4	-0.4	1.2	-0.5	0.5	0.5
Compulsive drug intake	1.6	1.6	2.1	-1.1	1.4	-1.0	1.5	1.3
One hour access (shock baseline)	0.0	0.1	0.1	0.3	0.3	-0.2	-0.0	0.1
Social response proportion	0.4	0.4	0.8	-0.6	-0.1	-0.4	0.9	0.8
Social responses	0.1	0.2	0.6	0.2	-0.8	0.5	0.0	-0.0
Social time	1.0	1.3	2.7	-1.3	1.6	-0.6	1.0	0.6
Soleus weight	0.1	0.3	0.6	-0.7	0.4	0.3	-0.1	-0.8
Bone: stiffness	0.1	0.2	0.5	-0.7	-0.1	-0.6	0.0	0.1
Tibialis anterior weight	1.0	3.3	4.2	-2.0	2.0	-1.8	1.6	1.6
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.7	-0.8	0.1	-0.3	0.2	-0.1
Time to tail flick, vehicle, after self-admin	3.1	3.3	4.6	-2.1	1.7	-1.5	2.2	1.5
Time to tail flick, test, before self-admin	0.8	0.8	1.2	-1.0	0.8	-1.1	1.0	0.5
Time to tail flick, test, after self-admin	0.4	0.4	0.9	-0.1	-0.9	0.3	-0.5	-0.8
Delta time to tail flick, vehicle, before/after SA	0.8	0.8	1.5	-1.1	1.2	-0.6	0.8	0.2
Delta time to tail flick, test, before/after SA	0.2	0.2	0.5	0.3	-0.7	0.4	-0.3	-0.1
Tibia length	0.1	0.3	1.2	-1.1	-0.1	-0.5	0.0	0.2
Ambulatory time before self-admin	4.6	4.7	5.8	-1.5	2.2	-2.4	2.4	2.3
Ambulatory time after self-admin	0.2	0.2	0.3	-0.6	0.3	-0.1	0.6	0.3
Bone: tissue strength	0.3	0.3	1.5	-1.2	0.4	-0.1	0.0	-0.2
Total heroin consumption	1.8	2.2	2.9	1.3	-1.6	1.3	-1.3	-1.7
Bone: trabecular number	1.9	3.0	5.4	2.3	-1.2	1.8	-1.7	-1.5
Bone: trabecular spacing	0.8	1.1	2.0	-1.4	0.9	-1.1	0.9	0.7
Bone: trabecular thickness	0.4	0.4	1.1	0.2	-0.4	0.7	-0.6	-1.1
Bone: trabecular tissue density	0.5	0.7	1.4	-0.7	0.3	-1.2	0.6	1.1
Water consumed over 24 hours	1.6	1.9	2.5	0.6	-1.6	1.5	-1.4	-1.6
Number of responses in last shaping day	0.6	0.6	0.7	0.7	-0.6	0.8	-0.9	-0.8