Hub : Genes

Krt12

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Krt12	0.05	0.03	1.2e-04	0.03	0.04	0.03	0.02	1.3e-03	8.0e-05	1.8e-03	2.7e-03
2	PL	gene expression	Krt12	0.04	0.02	1.1e-04	0.03	0.03	0.03	0.03	4.6e-04	2.3e-04	3.8e-04	2.9e-04
3	NAcc	gene expression	Krt12	0.08	0.05	5.4e-05	0.04	0.04	0.04	0.04	1.8e-05	1.2e-05	9.0e-06	5.2e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	1.5	2.5	3.7	1.9	1.7	-1.0
Area under the delay curve	1.0	1.0	2.0	0.3	1.0	-1.4
BMI with tail	1.5	5.0	6.4	-2.5	-2.2	2.0
BMI without tail	0.1	0.3	0.4	-0.4	-0.6	0.5
Body weight	3.4	14.1	21.4	-4.6	-3.4	3.1
Weight adjusted by age	0.2	0.2	0.4	-0.6	0.3	0.3
Bone surface	0.1	0.1	0.3	0.0	0.0	0.5
Bone volume	0.1	0.2	0.3	0.4	0.1	0.5
Breakpoint value in progressive ratio session	0.3	0.3	0.5	0.7	0.6	-0.4
Number of licking bursts	0.1	0.1	0.2	0.5	-0.2	0.3
Context. condit. distance diff. score	0.5	0.6	1.3	-1.1	-0.1	-0.7
Locomotion velocity, session 1	0.1	0.1	0.2	-0.4	-0.3	0.1
Locomotion distance, session 1	1.3	1.6	2.6	-1.6	-1.2	0.9
Locomotion velocity, session 2	0.1	0.1	0.2	-0.3	0.1	-0.5
Locomotion distance, session 2	0.1	0.1	0.3	-0.6	-0.3	0.2
Locomotion velocity, session 3	0.2	0.3	0.5	0.2	0.4	-0.7
Locomotion distance, session 3	0.1	0.1	0.2	-0.5	-0.4	0.0
Stereotopy head waving bouts, day 3	2.5	3.0	3.6	1.7	1.9	-1.5
Stereotopy head waving duration, day 3	0.2	0.3	0.6	0.4	0.8	-0.3
Locomotion velocity, session 7	2.2	2.4	3.0	-1.3	-1.5	1.7
Locomotion distance, session 7	2.0	2.5	2.9	-1.5	-1.7	1.5
Stereotopy head waving bouts, day 7	1.3	1.4	2.0	1.0	1.4	-1.1
Stereotopy head waving duration, day 7	1.6	2.0	2.7	1.1	1.6	-1.4
Locomotion velocity, session 8	3.6	4.3	8.8	-3.0	-1.9	0.8
Locomotion distance, session 8	0.5	0.7	1.8	-1.3	-0.5	-0.2
Degree of sensitization distance	3.0	3.0	3.3	-1.8	-1.8	1.6
Degree of sensitization stereotypy	1.6	1.7	2.0	1.2	1.4	-1.3
Conditioned locomotion	0.5	0.6	0.7	0.6	0.9	-0.8
Cocaine response after cond. corrected	0.8	0.9	1.3	0.6	1.2	-1.0
Cocaine response after cond. not corrected	0.5	0.5	1.0	0.5	1.0	-0.5
Cocaine response before conditioning	0.2	0.3	0.7	-0.2	-0.3	0.8
Saline control response	0.2	0.3	0.6	-0.8	-0.2	0.4
Bone: connectivity density	2.2	3.5	5.0	2.2	2.0	-1.2
Bone: cortical apparent density	3.8	4.9	8.6	2.9	1.8	-1.8
Bone: cortical area	0.0	0.0	0.1	0.2	-0.0	0.2
Bone: cortical porosity	0.2	0.3	0.4	0.6	0.7	-0.1
Bone: cortical porosity	0.2	0.2	0.4	0.3	0.6	-0.2
Bone: cortical thickness	1.0	1.6	1.7	1.2	1.3	-1.3
Bone: cortical thickness	8.0	9.3	10.8	2.6	3.3	-3.3
Bone: cortical tissue density	3.8	4.9	8.6	2.9	1.8	-1.7
Condit. Reinf. active minus inactive responses	2.1	2.3	3.6	1.3	1.4	-1.9
Condit. Reinf. active-inactive response ratio	2.1	2.3	3.1	1.4	1.4	-1.8
Condit. Reinf. active responses	1.7	2.0	3.1	1.2	1.2	-1.8
Condit. Reinf. inactive responses	0.1	0.1	0.2	0.2	0.2	-0.4
Incentive salience index mean	1.5	1.9	2.1	1.4	1.2	-1.5
Condit. Reinf. lever presses	0.1	0.1	0.2	0.5	0.2	0.1
Condit. Reinf. active minus inactive responses	0.3	0.4	1.1	1.0	0.3	-0.3
Condit. Reinf. active-inactive response ratio	0.0	0.1	0.1	0.4	0.0	0.1
Condit. Reinf. active responses	0.8	1.1	2.6	1.6	0.7	-0.5
Condit. Reinf. inactive responses	1.5	1.8	3.4	1.9	1.1	-0.8
Condit. Reinf. lever presses	0.3	0.4	0.5	0.7	0.6	-0.7
Condit. Reinf. lever reinforcers received	1.1	1.6	3.1	1.8	1.0	-0.8
Conditioned reinforcement - actives	0.2	0.2	0.4	0.7	0.1	0.2
Conditioned reinforcement - inactives	0.5	0.6	1.5	1.2	-0.0	0.5
Conditioned locomotion	0.2	0.2	0.5	0.7	-0.1	0.5
Patch foraging indifference point 0 sec	0.2	0.3	0.8	0.9	0.3	-0.3
Patch foraging indifference point AUC	0.0	0.0	0.0	0.1	0.1	0.2
Delay disc. indifference point, 0s delay	1.2	1.3	1.9	1.1	1.0	-1.4
Delay disc. indifference point, 16s delay	3.8	3.8	6.7	0.7	2.1	-2.6
Delay disc. indifference point, 2s delay	0.3	0.4	0.8	0.9	0.5	-0.3
Delay disc. indifference point, 24s delay	0.3	0.3	0.5	-0.7	-0.2	-0.6
Delay disc. indifference point, 4s delay	2.6	2.7	3.8	1.0	1.8	-2.0
Delay disc. indifference point, 8s delay	0.0	0.0	0.0	0.0	-0.0	0.0
Indifference point function ln k	0.0	0.0	0.1	-0.3	0.1	-0.2
Indifference point function log k	0.0	0.0	0.1	-0.3	0.1	-0.2
Patch foraging total patch changes 0 sec	0.1	0.1	0.4	0.6	-0.0	0.0
Patch foraging total patch changes 12 sec	2.1	2.8	5.9	2.4	1.4	-0.7
Patch foraging total patch changes 18 sec	0.2	0.2	0.5	0.7	-0.2	0.2
Patch foraging total patch changes 24 sec	1.1	1.4	1.9	1.4	1.2	-0.9
Patch foraging total patch changes 6 sec	0.4	0.6	1.0	1.0	0.7	-0.4
Patch foraging time to switch 0 sec	0.2	0.2	0.3	0.5	0.4	-0.6
Patch foraging water rate 0 sec	0.0	0.0	0.0	0.1	-0.0	0.1
Patch foraging water rate 12 sec	0.0	0.0	0.1	0.2	0.1	-0.1
Patch foraging water rate 18 sec	0.3	0.4	0.8	0.5	0.9	-0.4
Patch foraging water rate 24 sec	0.1	0.2	0.3	0.6	0.3	0.3
Patch foraging water rate 6 sec	1.5	2.3	2.6	1.6	1.5	-1.4
Seeking ratio, delayed vs. immediate footshock	0.8	1.0	1.7	0.7	0.8	-1.3
Distance traveled before self-admin	0.1	0.1	0.1	-0.4	0.1	0.3
Distance traveled after self-admin	0.5	0.6	1.1	-1.0	-0.6	0.6
Extensor digitorum longus weight	6.6	26.0	35.9	-6.0	-5.0	4.1
Bone: elastic displacement	0.3	0.4	0.6	-0.1	-0.8	0.8
Bone: elastic work	0.2	0.2	0.3	0.5	0.5	-0.4
Bone: endosteal estimation	2.4	5.1	6.1	-2.2	-2.1	2.5
Bone: endosteal perimeter	1.7	3.6	4.4	-1.5	-2.0	2.1
Epididymis fat weight	0.4	1.0	2.2	-0.5	-0.7	1.5
Delta time in closed arm before/after self-admin	1.5	1.5	2.8	-1.7	-1.1	0.7
Delta time in open arm before/after self-admin	0.1	0.1	0.1	0.2	0.3	-0.3
Diff in mean of infusions in LGA sessions	0.1	0.1	0.2	0.4	0.3	-0.1
Delay discount exponential model param	0.9	0.9	1.8	-0.1	-0.9	1.4
Extinction: sum of active levers before priming	1.5	1.5	1.8	-1.4	-1.3	1.1
Active lever presses in extinction session 6	2.4	2.3	3.9	1.6	2.0	-0.8
Bone: final force	0.1	0.2	0.3	0.5	0.6	0.2
Bone: final moment	0.1	0.1	0.1	0.2	0.4	0.3
Food consumed during 24 hour testing period	0.6	0.7	1.0	-1.0	-0.8	0.7
Glucose	0.1	0.2	0.3	0.5	0.3	0.4
Heart weight	3.3	4.7	7.2	-2.7	-2.3	1.4
Delay discount hyperbolic model param	0.9	0.9	1.8	-0.2	-1.0	1.3
Intermittent access intake day 1-15 change	2.2	2.1	4.0	2.0	1.1	-1.1
Intermittent access intake escalation	2.6	2.6	4.2	2.0	1.4	-1.3
Intermittent access intake escalation 2	0.6	0.6	1.4	1.2	0.5	-0.6
Intermitt. access day 1 inactive lever presses	3.3	3.6	5.8	1.7	2.4	-1.4
Intermitt. access day 15 inactive lever presses	4.0	4.4	7.0	2.6	2.1	-1.5
Intermitt. access escalation Index	0.5	0.5	1.4	-1.2	-0.1	0.1
Intermittent access day 1 total infusions	0.0	0.0	0.1	-0.1	0.2	0.3
Intermittent access day 15 total infusions	1.9	2.2	2.5	1.5	1.6	-1.4
Intermittent access terminal intake (last 3 days)	1.2	1.3	1.6	1.3	1.3	-0.8
Intermittent access total infusions	0.5	0.5	0.8	0.6	0.9	-0.6
Intermittent access day 1 locomotion	0.4	0.4	1.0	0.2	-0.5	1.0
Intermittent access day 15 total locomotion	0.7	0.8	1.1	0.9	-0.7	1.1
Intermittent access total locomotion	0.5	0.6	1.6	1.3	0.1	0.3
Intermittent access standard deviation	3.1	3.3	5.9	2.4	1.6	-1.2
Left kidney weight	0.6	1.6	3.0	-1.2	0.6	-1.7
Right kidney weight	0.5	1.4	2.6	-0.2	1.2	-1.6
Cocaine induced anxiety	0.7	0.8	2.4	-1.5	0.0	-0.3
Post-drug Anxiety	0.3	0.4	0.6	-0.7	0.6	-0.5
Baseline Anxiety	0.3	0.4	1.0	1.0	0.1	0.3
Tail length	0.1	0.2	0.4	-0.7	0.0	-0.3
Length with tail	1.1	3.9	8.9	-3.0	-1.4	0.9
Length without tail	1.6	3.6	7.2	-2.7	-1.3	1.4
Times rat made contact with spout	0.1	0.2	0.3	0.5	-0.3	0.4
Lifetime Intake	0.7	0.8	1.4	0.6	1.2	-0.8
Liver weight, left	0.0	0.0	0.1	0.2	0.2	-0.2
Liver weight, right	2.7	4.5	7.3	1.4	2.7	-2.0
Locomotor activity	0.4	0.7	1.2	1.1	0.8	-0.6
Locomotor testing distance	1.7	2.8	4.7	2.2	1.4	-1.3
Locomotor testing rearing	5.2	8.1	11.0	3.3	2.8	-2.3
Locomotion in novel chamber	4.6	5.7	6.9	2.1	2.6	-2.4
Locomotion in novel chamber post-restriction	0.3	0.3	0.9	0.9	0.1	0.3
Fecal boli incidents, locomotor time 1	1.4	1.5	2.3	-0.5	-1.4	1.5
Change in fecal boli incidents, locomotor task	0.3	0.3	0.5	-0.0	0.6	-0.7
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.1	0.3	0.1	-0.3
Bouts of movement, locomotor time 1	0.1	0.2	0.3	-0.4	-0.1	0.5
Total resting periods, locomotor time 1	0.9	1.0	1.6	-1.0	-0.7	1.2
Rest time, locomotor task time 1	1.5	1.6	4.1	-0.0	-0.8	2.0
Distance moved, locomotor task time 1	1.9	2.1	4.8	0.2	1.2	-2.2
Vertical activity count, locomotor time 1	0.2	0.2	0.5	-0.2	0.1	-0.7
Time >=10cm from walls, locomotor time 2	0.6	0.7	1.5	1.2	0.7	-0.2
Bouts of movement, locomotor time 2	0.4	0.4	0.8	0.5	0.9	-0.4
Total resting periods, locomotor time 2	0.3	0.3	0.7	0.4	0.9	-0.4
Rest time, locomotor task time 2	1.2	1.4	1.8	-1.0	-1.1	1.4
Distance moved, locomotor task time 2	0.3	0.4	0.8	-0.3	0.5	-0.9
Vertical activity count, locomotor time 2	0.1	0.1	0.2	-0.5	-0.1	-0.4
Light reinforcement 1	1.8	3.2	4.8	2.2	1.8	-1.2
Light reinforcement 2	0.6	0.8	1.2	0.6	1.0	-1.1
Bone: marrow area	2.2	4.8	5.6	-2.1	-2.1	2.4
Bone: maximum diameter	0.0	0.0	0.1	0.2	-0.0	0.2
Bone: maximum force	0.2	0.3	0.8	-0.4	-0.3	0.9
Bone: maximum moment	0.3	0.5	1.0	-0.6	-0.5	1.0
Mean time between licks in bursts	3.0	4.2	5.6	-1.2	-2.4	2.4
Mean num. licks in bursts	0.0	0.0	0.1	-0.0	0.2	-0.3
Cd content in liver	0.1	0.1	0.3	0.1	0.5	-0.2
Co content in liver	0.4	0.5	1.1	-1.0	-0.5	0.1
Cu content in liver	0.3	0.4	0.9	0.0	0.5	-0.9
Fe content in liver	0.3	0.3	1.0	-1.0	-0.1	-0.1
K content in liver	4.3	4.2	5.0	2.0	2.2	-2.0
Mg content in liver	4.9	5.1	6.3	2.0	2.2	-2.5
Mn content in liver	5.3	6.0	7.4	2.7	2.3	-2.3
Na content in liver	0.8	0.8	1.3	1.1	1.1	-0.3
Rb content in liver	0.8	1.0	1.1	1.1	0.8	-1.0
Se content in liver	7.8	9.5	9.6	3.1	3.1	-3.1
Sr content in liver	0.0	0.0	0.0	0.2	0.1	-0.2
Zn content in liver	1.5	1.7	2.3	1.5	1.3	-1.1
Bone: minimum diameter	0.4	0.7	1.0	-0.8	-0.7	1.0
Time in familiar zone, hab. session 1	0.2	0.2	0.4	0.3	0.6	-0.3
Time in novel zone, hab. session 1	0.2	0.2	0.5	0.7	-0.1	-0.1
Total zone transitions, hab. session 1	1.1	1.5	3.4	-1.9	-1.0	0.3
Total locomotion distance, hab. session 1	0.2	0.3	0.8	-0.2	0.4	-0.9
Locomotion velocity, hab. session 1	0.2	0.3	0.4	-0.6	0.3	-0.7
Time in familiar zone, hab. session 2	2.8	2.9	4.2	1.2	1.7	-2.1
Time in novel zone, hab. session 2	0.7	0.7	1.6	-0.0	-0.8	1.3
Total zone transitions, hab. session 2	1.3	1.7	2.3	-1.5	-1.4	1.0
Total locomotion distance, hab. session 2	0.5	0.7	0.8	-0.8	-0.9	0.9
Locomotion velocity, hab. session 2	0.7	0.9	1.0	-1.0	-0.9	0.9
Novel to familiar place preference ratio	0.2	0.2	0.3	-0.6	0.3	-0.5
Novelty place preference	0.2	0.2	0.3	-0.6	0.2	-0.5
Time in novel zone, NPP test	0.3	0.3	0.6	-0.2	0.5	-0.8
Total zone transitions, NPP test	1.5	2.2	2.5	-1.6	-1.5	1.3
Total locomotion distance, NPP test	0.5	0.7	0.8	-0.8	-0.9	0.8
Locomotion velocity, NPP test	1.0	1.5	1.7	-1.3	-1.3	1.1
Intraocular pressure	3.3	4.6	7.3	-2.7	-2.3	1.1
Delta distance traveled before/after self-admin	0.2	0.2	0.4	-0.6	-0.5	0.0
Delta ambulatory time before/after self-admin	0.2	0.2	0.3	-0.5	-0.5	0.0
Parametrial fat weight	0.8	1.6	2.3	1.5	1.4	-0.7
Pavlov. Cond. lever latency	0.4	0.5	0.8	-0.9	-0.9	0.3
Pavlov. Cond. magazine entry latency	5.6	7.2	10.2	3.2	2.8	-2.0
Pavlov. Cond. change in total contacts	5.4	5.8	6.5	2.4	2.5	-2.2
Pavlov. Cond. index score	2.5	3.2	5.2	2.3	1.8	-1.0
Pavlov. Cond. latency score	1.6	2.0	3.3	1.8	1.5	-0.6
Pavlov. Cond. lever contacts	0.2	0.2	0.3	0.6	0.4	0.3
Pavlov. Cond. magazine entry number	6.4	8.0	11.2	-3.3	-2.8	2.2
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.8	-0.9	-0.8	0.2
Pavlov. Cond. lever-magazine prob. diff.	2.9	3.6	6.0	2.5	1.9	-1.1
Pavlov. Cond. response bias	4.4	5.3	6.7	2.6	2.4	-1.8
Pavlov. Cond. lever latency	0.3	0.4	0.9	-1.0	-0.4	0.3
Pavlov. Cond. magazine entry latency	0.1	0.1	0.1	-0.3	-0.3	0.3
Pavlov. Cond. change in total contacts	0.3	0.5	1.3	1.1	0.2	-0.1
Pavlov. Cond. index score	0.1	0.1	0.3	0.6	0.0	-0.0
Pavlov. Cond. latency score	0.1	0.1	0.2	0.4	-0.2	0.2
Pavlov. Cond. lever contacts	0.4	0.6	1.3	1.1	0.5	-0.4
Pavlov. Cond. magazine entry number	0.1	0.1	0.1	-0.3	-0.2	0.3
Pavlov. Cond. intertrial magazine entries	1.0	1.3	2.5	-1.6	-1.0	0.6
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	0.4	-0.0	0.1
Pavlov. Cond. response bias	0.7	1.0	1.7	1.3	0.8	-0.8
Time in closed arm before self-admin	0.9	1.0	1.6	1.3	0.8	-0.8
Time in closed arm after self-admin	0.2	0.2	0.4	0.0	0.2	-0.7
Time in open arm before self-admin	0.8	0.9	1.7	-1.3	-0.7	0.7
Time in open arm after self-admin	0.6	0.7	0.7	-0.9	-0.8	0.8
Bone: periosteal estimation	0.5	0.9	1.5	-0.8	-0.8	1.2
Bone: periosteal perimeter	0.9	1.6	2.3	-0.9	-1.3	1.5
Bone: post-yield work	1.8	2.5	3.1	-1.8	-1.5	1.4
Progressive ratio test 1 active lever presses	0.3	0.4	0.7	0.5	0.8	-0.3
Progressive ratio test 1 breakpoint	0.3	0.4	0.7	0.5	0.8	-0.3
Progressive ratio test 1 inactive lever presses	1.5	1.7	2.4	1.2	1.6	-1.1
Progressive ratio test 2 active lever presses	0.5	0.6	1.4	1.2	0.5	-0.2
Progressive ratio test 2 breakpoint	0.4	0.5	1.2	1.1	0.5	-0.1
Progressive ratio test 2 inactive lever presses	0.3	0.4	0.8	0.9	0.5	-0.3
Incentive Sensitization - Responses	0.6	0.6	0.8	0.9	-0.6	0.8
Incentive Sensitization - Breakpoint	0.5	0.5	1.0	1.0	-0.5	0.6
Sum of active levers in priming session hrs 5-6	1.8	1.8	2.5	1.0	1.6	-1.3
Progressive ratio	0.1	0.1	0.2	0.5	0.3	-0.2
Food seeking constrained by brief footshock	0.3	0.4	0.5	0.5	0.7	-0.7
Seeking ratio, punishment vs. effort	0.0	0.0	0.0	-0.1	-0.1	-0.1
Retroperitoneal fat weight	0.0	0.2	0.3	-0.6	-0.1	0.4
Reaction time number correct	1.3	1.8	2.6	-1.2	-1.2	1.6
Reaction time mean minus median	1.5	2.0	3.2	-0.7	-1.5	1.8
Reaction time mean minus median AUC	0.6	0.8	1.5	-0.3	-1.0	1.2
Reaction time num false alarms	0.2	0.2	0.7	0.8	0.1	-0.0
Reaction time num false alarms AUC	0.2	0.3	0.5	0.7	-0.3	0.4
Reaction time trials correct on left	1.3	1.8	2.6	-1.2	-1.2	1.6
Reaction time trials on left	1.3	1.8	2.6	-1.2	-1.2	1.6
Reaction time mean	0.6	0.8	1.1	1.0	0.8	-0.8
Reaction time mean AUC	0.7	1.0	1.1	1.1	1.0	-0.9
Median of all reaction times	2.1	2.8	3.1	1.8	1.6	-1.7
Reaction time omissions	0.7	0.9	1.6	1.3	0.9	-0.6
Reaction time false alarm rate	0.5	0.6	1.5	1.2	0.4	-0.5
Reaction time premature initiation rate	3.3	4.5	6.1	1.3	2.5	-2.3
Reaction time premature initiations	0.8	1.1	1.9	0.4	1.4	-1.0
Std. dev. reaction times	0.3	0.4	0.8	0.2	-0.6	0.9
Reaction time trials completed	1.3	1.8	2.6	-1.2	-1.2	1.6
Reaction time trials AUC	1.3	1.8	2.7	-1.1	-1.3	1.7
Run reversals in cocaine runway, females	1.2	1.1	2.9	-1.7	0.1	-0.8
Run reversals in cocaine runway, males	0.5	0.5	1.0	0.2	0.6	-1.0
Latency to leave start box in cocaine runway	0.5	0.5	0.9	-1.0	-0.8	0.1
Latency to leave start box in cocaine runway, F	0.4	0.4	1.1	-1.0	-0.3	0.0
Latency to leave start box in cocaine runway, M	0.2	0.2	0.3	0.5	0.1	-0.6
Std. dev. time between licks in bursts	0.3	0.4	0.7	0.1	-0.7	0.9
Total sessions with >9 infusions	1.2	1.3	1.7	0.9	1.3	-1.1
Short access day 1 total inactive lever presses	0.9	0.9	1.5	1.0	1.2	-0.5
Short access day 10 total inactive lever presses	0.1	0.1	0.2	-0.3	0.4	-0.1
Short access day 1 total infusions	1.8	2.0	3.6	0.8	1.9	-1.3
Short access day 10 total infusions	0.2	0.2	0.4	0.4	0.6	-0.0
Short access total infusions	1.3	1.5	2.7	0.6	1.6	-1.2
Short access day 1 locomotion	2.6	2.8	3.4	1.8	1.8	-1.3
Short access day 10 total locomotion	1.0	1.1	2.0	1.4	-0.2	1.1
Short access total locomotion	0.3	0.3	0.5	0.7	0.1	0.5
One hour access (0.3 mA shock)	0.0	0.0	0.1	0.2	0.2	0.0
Compulsive drug intake	1.4	1.4	1.8	-1.1	-1.4	1.1
One hour access (shock baseline)	0.7	0.9	1.3	0.9	1.2	-0.7
Social response proportion	0.3	0.4	0.8	-0.9	-0.1	-0.6
Social responses	0.1	0.1	0.2	-0.1	0.3	-0.5
Social time	1.1	1.5	2.2	-1.0	-1.2	1.5
Soleus weight	0.2	0.5	1.0	-0.4	-0.6	1.0
Bone: stiffness	0.1	0.1	0.2	-0.2	0.5	0.1
Tibialis anterior weight	0.8	2.7	5.3	-2.3	-1.2	1.1
Time to tail flick, vehicle, before self-admin	1.6	1.7	2.3	-0.7	-1.5	1.5
Time to tail flick, vehicle, after self-admin	1.0	1.1	2.2	-0.6	-0.8	1.5
Time to tail flick, test, before self-admin	0.9	0.9	1.1	-1.0	-1.0	0.7
Time to tail flick, test, after self-admin	0.8	0.8	1.5	-0.3	-0.9	1.2
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.5	0.3	0.1	0.7
Delta time to tail flick, test, before/after SA	0.1	0.1	0.3	0.6	0.2	0.1
Tibia length	1.3	3.8	6.9	-2.6	-1.5	1.5
Ambulatory time before self-admin	0.3	0.3	0.5	-0.7	-0.3	0.5
Ambulatory time after self-admin	1.2	1.3	2.3	-1.5	-0.9	0.9
Bone: tissue strength	3.0	3.0	3.6	-1.3	-1.9	1.9
Total heroin consumption	0.9	1.0	2.2	1.5	0.8	-0.3
Bone: trabecular number	3.5	5.5	8.0	2.8	2.5	-1.5
Bone: trabecular spacing	1.6	2.1	3.5	-1.9	-1.4	0.9
Bone: trabecular thickness	0.2	0.2	0.3	0.5	-0.2	0.5
Bone: trabecular tissue density	0.0	0.1	0.1	-0.3	-0.1	-0.2
Water consumed over 24 hours	0.3	0.4	0.6	-0.3	-0.7	0.8
Number of responses in last shaping day	1.4	1.5	2.2	1.5	1.1	-1.0