Hub : Genes

Kremen1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Kremen1	0.04	0.03	1.9e-04	0.04	0.03	0.04	0.04	1.8e-04	4.5e-04	9.7e-05	1.1e-04
2	Adipose	gene expression	Kremen1	0.13	0.09	3.2e-08	0.05	0.05	0.05	0.05	1.8e-06	2.6e-06	1.9e-06	1.8e-06
3	BLA	gene expression	Kremen1	0.16	0.09	3.1e-08	0.1	0.14	0.11	0.11	9.0e-06	1.1e-07	1.2e-06	1.7e-06
4	Liver	gene expression	Kremen1	0.04	0.03	5.0e-03	0.01	0	0	0	1.3e-02	7.3e-02	3.5e-01	9.5e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.1	0.2	0.4	-0.5	0.6	0.4	-0.2
Area under the delay curve	4.0	4.2	5.5	2.3	-2.2	-2.0	-1.6
BMI with tail	0.0	0.0	0.0	-0.2	0.1	0.1	0.1
BMI without tail	0.1	0.1	0.5	-0.0	0.2	0.3	-0.7
Body weight	1.4	5.7	6.8	2.6	-2.3	-2.3	-2.3
Weight adjusted by age	1.0	1.2	2.4	1.1	-0.8	-0.7	-1.5
Bone surface	0.2	0.3	0.4	0.5	-0.3	-0.6	-0.6
Bone volume	0.1	0.2	0.5	0.4	-0.2	-0.5	-0.7
Breakpoint value in progressive ratio session	1.7	1.8	2.3	1.5	-1.4	-1.3	-1.1
Number of licking bursts	3.1	3.6	4.3	2.1	-1.8	-1.9	-1.8
Context. condit. distance diff. score	4.1	4.9	6.2	-2.5	2.3	2.3	1.8
Locomotion velocity, session 1	0.6	0.6	2.2	-0.1	-0.3	-0.3	1.5
Locomotion distance, session 1	0.6	0.8	1.2	-1.0	1.1	1.0	0.1
Locomotion velocity, session 2	0.5	0.6	2.1	-0.3	-0.1	-0.3	1.4
Locomotion distance, session 2	2.1	3.0	3.8	-2.0	1.7	1.4	1.8
Locomotion velocity, session 3	2.8	3.2	4.3	-2.1	2.1	1.8	1.0
Locomotion distance, session 3	0.0	0.0	0.0	-0.1	0.2	-0.2	-0.1
Stereotopy head waving bouts, day 3	1.0	1.2	1.5	-1.2	1.2	1.1	0.6
Stereotopy head waving duration, day 3	1.8	2.1	2.5	-1.6	1.4	1.5	1.3
Locomotion velocity, session 7	0.1	0.1	0.2	0.3	-0.4	-0.4	-0.1
Locomotion distance, session 7	0.5	0.6	1.0	-0.8	0.7	0.5	1.0
Stereotopy head waving bouts, day 7	0.3	0.3	0.4	-0.6	0.6	0.7	0.4
Stereotopy head waving duration, day 7	0.1	0.1	0.2	-0.0	0.2	0.2	-0.5
Locomotion velocity, session 8	2.1	2.5	4.0	-1.7	1.3	1.2	2.0
Locomotion distance, session 8	8.6	12.6	15.8	-4.0	3.6	3.5	3.0
Degree of sensitization distance	2.1	2.1	3.1	-1.5	1.2	1.3	1.8
Degree of sensitization stereotypy	0.2	0.2	0.2	0.5	-0.4	-0.3	-0.5
Conditioned locomotion	1.1	1.3	1.9	-1.2	1.3	1.4	0.0
Cocaine response after cond. corrected	2.1	2.4	3.0	1.7	-1.6	-1.4	-1.4
Cocaine response after cond. not corrected	2.7	2.9	3.6	1.9	-1.6	-1.4	-1.9
Cocaine response before conditioning	0.3	0.3	0.5	-0.6	0.7	0.7	0.1
Saline control response	1.0	1.3	1.7	-1.3	1.1	0.9	1.3
Bone: connectivity density	0.2	0.4	0.6	-0.7	0.8	0.6	0.0
Bone: cortical apparent density	0.8	1.0	1.2	1.1	-1.0	-1.0	-1.0
Bone: cortical area	3.2	4.8	5.9	2.4	-2.2	-2.1	-2.1
Bone: cortical porosity	0.2	0.2	0.5	0.3	-0.2	-0.1	-0.7
Bone: cortical porosity	0.1	0.1	0.2	-0.3	0.4	0.4	-0.0
Bone: cortical thickness	2.2	3.6	5.4	2.0	-1.6	-1.6	-2.3
Bone: cortical thickness	0.5	0.6	0.9	-0.7	1.0	0.9	-0.5
Bone: cortical tissue density	0.8	1.1	1.3	1.2	-1.0	-1.0	-0.9
Condit. Reinf. active minus inactive responses	0.6	0.7	1.1	0.6	-0.9	-1.1	0.6
Condit. Reinf. active-inactive response ratio	1.0	1.1	4.2	-0.3	-0.3	-0.4	2.1
Condit. Reinf. active responses	0.2	0.2	0.5	0.3	-0.5	-0.7	0.4
Condit. Reinf. inactive responses	0.3	0.4	1.3	0.4	-0.1	-0.3	-1.1
Incentive salience index mean	0.7	0.8	1.5	0.9	-1.0	-1.2	0.0
Condit. Reinf. lever presses	0.1	0.2	0.2	0.4	-0.3	-0.4	-0.5
Condit. Reinf. active minus inactive responses	0.6	0.7	0.9	-0.9	0.8	0.7	0.9
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.3	0.2	0.1	0.4
Condit. Reinf. active responses	0.8	1.1	1.4	-1.1	0.9	0.9	1.2
Condit. Reinf. inactive responses	0.9	1.1	1.5	-1.1	0.9	0.9	1.2
Condit. Reinf. lever presses	0.6	0.8	1.0	-1.0	1.0	0.9	0.6
Condit. Reinf. lever reinforcers received	0.7	0.9	1.1	-1.1	0.9	0.8	1.1
Conditioned reinforcement - actives	0.0	0.0	0.0	0.1	-0.2	-0.0	0.1
Conditioned reinforcement - inactives	0.1	0.1	0.2	0.3	-0.4	-0.3	-0.0
Conditioned locomotion	0.1	0.2	0.3	0.4	-0.4	-0.1	-0.6
Patch foraging indifference point 0 sec	2.0	3.2	3.7	1.9	-1.8	-1.7	-1.7
Patch foraging indifference point AUC	0.1	0.1	0.2	0.3	-0.3	-0.4	0.0
Delay disc. indifference point, 0s delay	1.2	1.3	1.7	1.3	-1.1	-1.0	-1.1
Delay disc. indifference point, 16s delay	3.1	3.1	4.4	2.0	-2.1	-1.9	-0.7
Delay disc. indifference point, 2s delay	1.8	2.0	3.8	1.5	-1.2	-0.9	-1.9
Delay disc. indifference point, 24s delay	1.2	1.2	1.6	1.2	-1.2	-1.3	-0.3
Delay disc. indifference point, 4s delay	3.5	3.7	4.5	2.1	-1.8	-1.7	-1.9
Delay disc. indifference point, 8s delay	1.3	1.3	1.8	1.3	-1.4	-1.2	-0.6
Indifference point function ln k	0.1	0.1	0.3	-0.2	0.3	0.2	-0.5
Indifference point function log k	0.1	0.1	0.3	-0.2	0.3	0.2	-0.5
Patch foraging total patch changes 0 sec	1.9	3.1	3.7	1.9	-1.8	-1.8	-1.6
Patch foraging total patch changes 12 sec	1.3	1.7	2.1	1.4	-1.3	-1.3	-1.2
Patch foraging total patch changes 18 sec	1.8	2.3	3.3	1.7	-1.8	-1.8	-0.3
Patch foraging total patch changes 24 sec	0.9	1.1	2.0	-1.0	0.7	0.8	1.4
Patch foraging total patch changes 6 sec	1.6	2.3	2.9	1.6	-1.6	-1.7	-1.2
Patch foraging time to switch 0 sec	0.2	0.4	0.6	-0.6	0.6	0.8	0.4
Patch foraging water rate 0 sec	1.4	2.2	3.0	1.6	-1.6	-1.7	-0.8
Patch foraging water rate 12 sec	0.0	0.0	0.0	0.1	0.1	-0.2	0.1
Patch foraging water rate 18 sec	0.3	0.4	1.3	0.0	0.3	0.4	-1.1
Patch foraging water rate 24 sec	0.1	0.2	0.5	0.1	-0.3	-0.3	0.7
Patch foraging water rate 6 sec	0.3	0.5	0.6	0.8	-0.6	-0.6	-0.8
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.2	-0.3	0.2	0.5	0.4
Distance traveled before self-admin	0.9	0.9	2.3	0.9	-0.6	-0.5	-1.5
Distance traveled after self-admin	0.4	0.4	1.3	0.6	-0.3	-0.3	-1.1
Extensor digitorum longus weight	3.4	13.2	16.0	4.0	-3.5	-3.6	-3.4
Bone: elastic displacement	0.5	0.6	0.9	-0.7	0.9	0.9	-0.2
Bone: elastic work	0.3	0.4	1.4	0.3	0.0	0.1	-1.2
Bone: endosteal estimation	0.1	0.3	0.4	0.6	-0.5	-0.4	-0.5
Bone: endosteal perimeter	0.8	1.6	2.1	1.5	-1.4	-1.2	-0.9
Epididymis fat weight	0.3	0.8	1.1	-0.8	1.0	1.1	-0.4
Delta time in closed arm before/after self-admin	5.5	5.4	6.7	-2.6	2.4	2.6	1.5
Delta time in open arm before/after self-admin	9.0	8.7	11.3	3.4	-3.1	-3.0	-2.2
Diff in mean of infusions in LGA sessions	0.1	0.1	0.2	-0.2	0.2	0.5	-0.2
Delay discount exponential model param	3.6	3.8	4.9	-2.2	2.1	1.9	1.5
Extinction: sum of active levers before priming	0.4	0.4	0.6	0.6	-0.7	-0.8	0.0
Active lever presses in extinction session 6	0.5	0.5	1.1	0.7	-0.6	-0.3	-1.0
Bone: final force	0.4	0.6	0.7	0.8	-0.7	-0.7	-0.7
Bone: final moment	0.6	0.9	1.1	1.0	-0.9	-0.9	-1.0
Food consumed during 24 hour testing period	1.4	1.7	2.9	1.3	-1.4	-1.7	-0.1
Glucose	14.9	22.4	33.4	5.0	-5.6	-5.8	-0.2
Heart weight	0.9	1.2	2.7	-1.1	0.8	0.6	1.6
Delay discount hyperbolic model param	3.7	3.9	5.0	-2.2	2.1	1.9	1.6
Intermittent access intake day 1-15 change	0.2	0.2	0.3	0.2	-0.4	-0.6	0.5
Intermittent access intake escalation	0.1	0.1	0.2	0.0	-0.2	-0.4	0.5
Intermittent access intake escalation 2	0.1	0.1	0.1	0.1	-0.1	-0.3	0.4
Intermitt. access day 1 inactive lever presses	1.5	1.6	2.1	-1.4	1.2	0.9	1.4
Intermitt. access day 15 inactive lever presses	0.6	0.7	1.2	0.7	-0.9	-1.1	0.5
Intermitt. access escalation Index	0.1	0.1	0.2	0.1	-0.1	-0.3	0.5
Intermittent access day 1 total infusions	0.1	0.1	0.3	0.4	-0.3	0.3	-0.5
Intermittent access day 15 total infusions	0.4	0.4	0.7	0.8	-0.8	-0.5	-0.4
Intermittent access terminal intake (last 3 days)	0.3	0.3	0.5	0.7	-0.7	-0.4	-0.4
Intermittent access total infusions	0.3	0.4	0.5	0.7	-0.7	-0.3	-0.6
Intermittent access day 1 locomotion	0.4	0.4	0.9	-0.6	0.5	0.9	0.3
Intermittent access day 15 total locomotion	0.3	0.3	0.5	0.6	-0.7	-0.6	-0.1
Intermittent access total locomotion	0.5	0.5	0.8	0.9	-0.9	-0.5	-0.5
Intermittent access standard deviation	1.2	1.3	1.5	-1.2	1.1	1.2	0.9
Left kidney weight	0.0	0.1	0.3	-0.1	0.2	0.4	-0.5
Right kidney weight	0.6	1.6	2.9	-1.1	1.4	1.7	-0.2
Cocaine induced anxiety	2.4	2.7	3.6	1.9	-1.7	-1.9	-1.1
Post-drug Anxiety	0.7	0.8	1.2	1.1	-1.0	-1.1	-0.2
Baseline Anxiety	0.3	0.3	0.8	-0.5	0.3	0.4	0.9
Tail length	2.0	6.1	9.9	2.6	-2.1	-1.8	-3.2
Length with tail	2.5	9.2	11.6	3.4	-3.0	-2.7	-3.0
Length without tail	1.3	2.9	3.7	1.9	-1.9	-1.8	-0.9
Times rat made contact with spout	0.5	0.6	2.1	-0.1	-0.3	-0.4	1.4
Lifetime Intake	0.5	0.6	0.9	0.9	-0.8	-0.3	-0.9
Liver weight, left	1.2	2.0	3.5	-1.3	1.6	1.9	-0.2
Liver weight, right	2.5	4.1	6.5	-2.1	2.3	2.5	0.5
Locomotor activity	0.7	1.2	1.7	1.3	-1.3	-1.2	-0.1
Locomotor testing distance	0.5	0.8	1.9	0.9	-0.5	-0.4	-1.4
Locomotor testing rearing	1.9	3.0	3.8	2.0	-1.8	-1.7	-1.4
Locomotion in novel chamber	3.7	4.6	6.0	-2.3	2.3	2.5	1.2
Locomotion in novel chamber post-restriction	4.0	4.8	6.9	-2.3	1.9	1.8	2.6
Fecal boli incidents, locomotor time 1	0.4	0.4	0.6	-0.7	0.6	0.5	0.7
Change in fecal boli incidents, locomotor task	0.2	0.2	0.5	0.1	-0.3	-0.3	0.7
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.0	-0.1	0.1	0.1	0.2
Bouts of movement, locomotor time 1	0.6	0.6	0.9	0.7	-1.0	-0.9	0.4
Total resting periods, locomotor time 1	0.4	0.4	0.9	0.3	-0.6	-0.6	0.9
Rest time, locomotor task time 1	0.1	0.2	0.5	-0.1	-0.1	-0.2	0.7
Distance moved, locomotor task time 1	0.5	0.6	1.5	0.7	-0.4	-0.3	-1.2
Vertical activity count, locomotor time 1	0.2	0.3	0.6	0.5	-0.3	-0.2	-0.8
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.1	-0.2	0.1	0.3	0.4
Bouts of movement, locomotor time 2	0.0	0.0	0.0	0.1	-0.0	0.1	-0.0
Total resting periods, locomotor time 2	0.0	0.0	0.0	0.1	-0.1	0.0	0.0
Rest time, locomotor task time 2	0.1	0.1	0.2	-0.4	0.3	0.2	0.5
Distance moved, locomotor task time 2	0.1	0.1	0.1	-0.3	0.2	0.2	0.2
Vertical activity count, locomotor time 2	0.0	0.0	0.0	-0.1	0.1	0.1	-0.0
Light reinforcement 1	0.2	0.5	1.4	0.5	-0.3	-0.2	-1.2
Light reinforcement 2	0.5	0.7	1.9	0.7	-0.5	-0.2	-1.4
Bone: marrow area	0.1	0.2	0.2	0.5	-0.4	-0.3	-0.3
Bone: maximum diameter	4.4	8.2	10.2	3.2	-3.1	-3.2	-1.6
Bone: maximum force	0.4	0.6	1.0	0.8	-0.7	-0.6	-1.0
Bone: maximum moment	0.6	1.0	1.6	1.1	-0.8	-0.8	-1.3
Mean time between licks in bursts	0.6	0.8	1.1	0.7	-1.0	-1.0	0.9
Mean num. licks in bursts	2.9	3.5	6.4	-1.9	1.4	1.4	2.5
Cd content in liver	0.2	0.2	0.4	-0.5	0.6	0.6	0.0
Co content in liver	0.0	0.0	0.1	-0.2	0.3	0.1	-0.2
Cu content in liver	0.3	0.4	0.6	0.6	-0.6	-0.8	-0.3
Fe content in liver	1.2	1.4	4.7	-0.9	0.4	0.3	2.2
K content in liver	1.3	1.3	3.8	0.9	-0.4	-0.5	-2.0
Mg content in liver	0.4	0.4	1.0	0.5	-0.3	-0.5	-1.0
Mn content in liver	0.7	0.8	2.9	0.3	0.1	0.0	-1.7
Na content in liver	3.8	4.0	5.1	2.2	-2.2	-2.3	-0.9
Rb content in liver	3.6	4.5	5.9	2.3	-1.9	-1.8	-2.4
Se content in liver	1.7	2.0	2.8	1.5	-1.2	-1.3	-1.7
Sr content in liver	1.6	1.5	2.2	1.3	-1.5	-1.4	-0.1
Zn content in liver	0.4	0.4	0.8	0.6	-0.4	-0.5	-0.9
Bone: minimum diameter	0.0	0.1	0.2	0.1	0.0	0.0	-0.5
Time in familiar zone, hab. session 1	0.1	0.1	0.2	-0.4	0.4	0.4	0.1
Time in novel zone, hab. session 1	0.6	0.6	0.9	0.8	-0.7	-0.6	-0.9
Total zone transitions, hab. session 1	0.0	0.0	0.0	-0.1	0.0	-0.1	0.1
Total locomotion distance, hab. session 1	0.1	0.2	0.4	0.4	-0.3	-0.3	-0.6
Locomotion velocity, hab. session 1	0.0	0.0	0.0	0.0	-0.1	-0.1	0.1
Time in familiar zone, hab. session 2	1.7	1.7	2.0	-1.4	1.2	1.3	1.3
Time in novel zone, hab. session 2	2.4	2.4	2.7	1.7	-1.4	-1.6	-1.5
Total zone transitions, hab. session 2	0.5	0.7	0.9	0.9	-0.8	-0.9	-0.6
Total locomotion distance, hab. session 2	0.6	0.7	1.2	0.9	-0.9	-1.1	-0.3
Locomotion velocity, hab. session 2	0.8	1.1	1.5	1.1	-1.1	-1.2	-0.6
Novel to familiar place preference ratio	0.9	0.9	1.4	1.1	-1.2	-1.1	-0.0
Novelty place preference	1.0	1.0	1.5	1.1	-1.2	-1.2	-0.0
Time in novel zone, NPP test	0.9	1.0	1.4	1.1	-1.2	-1.1	-0.0
Total zone transitions, NPP test	0.5	0.6	1.0	-0.9	1.0	0.9	-0.0
Total locomotion distance, NPP test	0.1	0.1	0.2	-0.4	0.5	0.4	-0.0
Locomotion velocity, NPP test	0.0	0.0	0.0	-0.1	0.2	0.1	-0.2
Intraocular pressure	0.3	0.4	0.6	0.5	-0.7	-0.8	0.3
Delta distance traveled before/after self-admin	0.5	0.5	0.7	-0.8	0.7	0.5	0.9
Delta ambulatory time before/after self-admin	1.0	1.1	1.4	-1.2	1.1	0.8	1.1
Parametrial fat weight	1.7	3.3	4.9	1.8	-2.2	-2.2	0.2
Pavlov. Cond. lever latency	0.6	0.7	1.1	1.0	-1.1	-1.0	-0.1
Pavlov. Cond. magazine entry latency	2.5	3.2	4.2	-2.1	2.0	1.8	1.2
Pavlov. Cond. change in total contacts	0.5	0.6	0.9	0.8	-0.7	-0.9	-0.5
Pavlov. Cond. index score	2.7	3.4	4.5	-2.1	2.1	1.9	1.1
Pavlov. Cond. latency score	2.1	2.7	3.6	-1.9	1.9	1.7	0.9
Pavlov. Cond. lever contacts	1.2	1.4	2.0	-1.4	1.4	1.2	0.6
Pavlov. Cond. magazine entry number	3.1	3.9	5.1	2.3	-2.1	-1.8	-1.6
Pavlov. Cond. intertrial magazine entries	1.0	1.2	2.5	1.1	-0.8	-0.6	-1.6
Pavlov. Cond. lever-magazine prob. diff.	3.2	4.0	5.2	-2.3	2.2	2.0	1.2
Pavlov. Cond. response bias	1.7	2.1	2.9	-1.7	1.7	1.4	0.8
Pavlov. Cond. lever latency	4.9	6.6	9.0	2.8	-2.2	-2.2	-3.0
Pavlov. Cond. magazine entry latency	0.0	0.1	0.1	-0.3	0.3	0.1	0.1
Pavlov. Cond. change in total contacts	0.3	0.4	0.8	-0.6	0.4	0.5	0.9
Pavlov. Cond. index score	1.7	2.1	2.6	-1.6	1.3	1.3	1.6
Pavlov. Cond. latency score	1.7	2.1	2.7	-1.6	1.4	1.3	1.5
Pavlov. Cond. lever contacts	3.8	5.1	7.5	-2.4	1.9	1.9	2.7
Pavlov. Cond. magazine entry number	0.1	0.1	0.3	0.3	-0.2	-0.1	-0.6
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.0	-0.0	-0.0	-0.0	0.1
Pavlov. Cond. lever-magazine prob. diff.	1.5	1.9	2.4	-1.5	1.3	1.3	1.4
Pavlov. Cond. response bias	1.8	2.4	4.2	-1.6	1.2	1.2	2.0
Time in closed arm before self-admin	0.5	0.6	0.9	0.8	-0.5	-0.7	-0.9
Time in closed arm after self-admin	2.1	2.1	2.8	-1.7	1.7	1.5	0.8
Time in open arm before self-admin	2.7	2.9	3.6	-1.9	1.6	1.7	1.5
Time in open arm after self-admin	0.4	0.4	0.7	0.7	-0.9	-0.6	0.3
Bone: periosteal estimation	1.2	2.5	3.2	1.8	-1.6	-1.5	-1.5
Bone: periosteal perimeter	2.1	3.6	4.5	2.1	-1.9	-1.8	-1.6
Bone: post-yield work	0.2	0.3	0.4	0.6	-0.6	-0.6	-0.5
Progressive ratio test 1 active lever presses	0.1	0.1	0.2	0.4	-0.4	-0.2	-0.1
Progressive ratio test 1 breakpoint	0.0	0.0	0.1	0.0	-0.1	0.2	0.1
Progressive ratio test 1 inactive lever presses	2.1	2.3	2.7	1.7	-1.6	-1.6	-1.1
Progressive ratio test 2 active lever presses	0.1	0.1	0.2	0.4	-0.4	-0.2	-0.3
Progressive ratio test 2 breakpoint	0.1	0.1	0.2	0.4	-0.4	-0.2	-0.2
Progressive ratio test 2 inactive lever presses	0.6	0.7	1.1	0.9	-1.0	-0.9	-0.1
Incentive Sensitization - Responses	0.0	0.0	0.1	0.2	-0.3	-0.2	0.1
Incentive Sensitization - Breakpoint	0.0	0.0	0.0	0.1	-0.2	-0.2	0.2
Sum of active levers in priming session hrs 5-6	0.5	0.4	0.7	0.6	-0.6	-0.8	-0.6
Progressive ratio	0.0	0.0	0.1	-0.0	0.1	0.3	-0.3
Food seeking constrained by brief footshock	3.1	3.8	6.7	2.1	-1.5	-1.4	-2.6
Seeking ratio, punishment vs. effort	1.0	1.2	1.4	1.2	-1.0	-1.1	-1.2
Retroperitoneal fat weight	0.0	0.1	0.4	-0.3	0.2	0.1	0.6
Reaction time number correct	0.0	0.1	0.2	-0.0	-0.1	-0.2	0.5
Reaction time mean minus median	2.0	2.6	4.4	-1.7	1.3	1.2	2.1
Reaction time mean minus median AUC	1.3	1.7	2.0	-1.4	1.3	1.2	1.3
Reaction time num false alarms	0.2	0.3	0.9	0.2	0.0	-0.2	-1.0
Reaction time num false alarms AUC	0.2	0.3	1.3	0.1	0.2	-0.1	-1.2
Reaction time trials correct on left	0.0	0.1	0.2	-0.0	-0.1	-0.2	0.5
Reaction time trials on left	0.1	0.1	0.3	-0.1	-0.0	-0.2	0.5
Reaction time mean	0.9	1.3	1.7	-1.2	1.0	1.0	1.3
Reaction time mean AUC	1.3	1.7	2.0	-1.4	1.3	1.3	1.3
Median of all reaction times	0.4	0.6	0.8	-0.8	0.7	0.7	0.9
Reaction time omissions	1.6	2.2	2.8	-1.7	1.6	1.5	1.1
Reaction time false alarm rate	0.3	0.5	1.8	0.1	0.2	0.0	-1.4
Reaction time premature initiation rate	2.8	3.7	5.1	-2.1	2.3	2.2	0.8
Reaction time premature initiations	1.6	2.3	3.1	-1.7	1.8	1.6	0.8
Std. dev. reaction times	1.7	2.3	3.8	-1.6	1.3	1.2	1.9
Reaction time trials completed	0.1	0.1	0.3	-0.1	-0.0	-0.2	0.5
Reaction time trials AUC	0.0	0.1	0.1	0.1	-0.2	-0.3	0.3
Run reversals in cocaine runway, females	0.9	0.9	1.2	-1.1	0.9	0.8	0.9
Run reversals in cocaine runway, males	0.6	0.6	0.7	0.8	-0.8	-0.7	-0.7
Latency to leave start box in cocaine runway	0.1	0.1	0.3	0.1	0.0	-0.0	-0.5
Latency to leave start box in cocaine runway, F	0.6	0.6	1.4	0.8	-0.5	-0.6	-1.2
Latency to leave start box in cocaine runway, M	0.6	0.6	0.7	-0.8	0.7	0.8	0.6
Std. dev. time between licks in bursts	0.1	0.1	0.2	-0.2	0.1	-0.0	0.5
Total sessions with >9 infusions	0.1	0.1	0.4	0.1	0.0	0.2	-0.6
Short access day 1 total inactive lever presses	4.3	4.8	6.1	2.5	-2.1	-1.9	-2.3
Short access day 10 total inactive lever presses	0.5	0.5	0.7	-0.9	0.8	0.6	0.7
Short access day 1 total infusions	0.2	0.2	0.3	-0.1	0.3	0.6	-0.6
Short access day 10 total infusions	0.1	0.2	0.4	0.2	-0.1	0.4	-0.6
Short access total infusions	0.2	0.3	0.7	0.1	0.1	0.6	-0.8
Short access day 1 locomotion	1.0	1.1	2.1	-0.9	1.2	1.4	-0.3
Short access day 10 total locomotion	0.3	0.3	0.7	-0.4	0.5	0.8	-0.2
Short access total locomotion	2.1	2.2	3.9	-1.5	1.6	2.0	0.3
One hour access (0.3 mA shock)	0.1	0.1	0.2	0.5	-0.4	-0.1	-0.4
Compulsive drug intake	2.9	3.0	3.8	-1.9	1.9	1.7	1.3
One hour access (shock baseline)	1.4	1.6	2.3	1.5	-1.4	-1.1	-1.0
Social response proportion	1.2	1.3	2.5	1.0	-1.3	-1.6	0.5
Social responses	1.5	1.9	3.4	1.4	-1.6	-1.8	0.0
Social time	0.2	0.2	0.5	0.1	-0.3	-0.6	0.7
Soleus weight	1.2	3.5	5.5	2.0	-1.6	-1.4	-2.3
Bone: stiffness	0.0	0.0	0.0	0.0	-0.1	-0.0	0.0
Tibialis anterior weight	1.2	4.0	5.0	2.2	-2.2	-2.1	-1.4
Time to tail flick, vehicle, before self-admin	0.0	0.0	0.0	-0.0	0.2	0.2	-0.1
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.1	-0.1	0.2	0.2	-0.2
Time to tail flick, test, before self-admin	0.6	0.6	0.8	-0.9	0.8	0.8	0.5
Time to tail flick, test, after self-admin	3.3	3.4	4.5	1.9	-1.7	-1.7	-2.1
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.0	0.1	-0.1	-0.0	-0.2
Delta time to tail flick, test, before/after SA	2.0	1.8	2.1	1.4	-1.4	-1.4	-1.1
Tibia length	0.2	0.5	1.6	0.1	0.3	0.5	-1.3
Ambulatory time before self-admin	1.8	1.8	4.5	1.3	-0.9	-0.7	-2.1
Ambulatory time after self-admin	0.5	0.6	1.4	0.7	-0.4	-0.4	-1.2
Bone: tissue strength	0.1	0.1	0.1	0.3	-0.4	-0.3	0.1
Total heroin consumption	0.2	0.2	0.2	0.5	-0.4	-0.3	-0.5
Bone: trabecular number	0.1	0.1	0.4	-0.1	0.3	0.3	-0.6
Bone: trabecular spacing	1.0	1.3	1.7	1.3	-1.3	-1.3	-0.5
Bone: trabecular thickness	1.2	1.5	2.2	-1.3	1.5	1.4	0.2
Bone: trabecular tissue density	0.5	0.6	1.9	-0.7	0.3	0.3	1.4
Water consumed over 24 hours	1.0	1.2	2.0	1.1	-1.2	-1.4	0.1
Number of responses in last shaping day	0.1	0.1	0.1	-0.1	0.3	0.2	-0.4