Kpnb1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Kpnb1 0.07 0.06 3.3e-03 0.04 0.03 0.04 0.04 1.4e-04 1.5e-03 1.1e-04 2.4e-04
2 BLA gene expression Kpnb1 0.13 0.11 3.3e-03 0.06 0.03 0.04 0.06 2.2e-04 9.3e-03 1.9e-03 3.5e-04
3 PL mRNA stability Kpnb1 0.03 0.02 7.0e-03 0.02 0.01 0.01 0.02 2.7e-03 8.3e-03 1.9e-02 4.5e-03
4 Liver gene expression Kpnb1 0.04 0.02 1.9e-05 0.04 0.04 0.03 0.03 5.9e-05 3.6e-05 9.9e-05 1.5e-04
5 Brain mRNA stability Kpnb1 0.04 0.03 2.8e-04 0.05 0.04 0.03 0.04 4.0e-05 1.0e-04 7.4e-04 1.0e-04
6 OFC gene expression Kpnb1 0.14 0.1 8.6e-03 0.07 0.02 0 0.01 9.1e-03 9.8e-02 2.6e-01 1.4e-01
7 PL gene expression Kpnb1 0.05 0.05 9.9e-04 0.02 0.02 0.03 0.02 1.6e-03 4.6e-03 3.7e-04 1.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bone: apparent density1.11.92.8-1.3-1.31.41.61.6-1.70.1
Area under the delay curve0.60.61.31.11.1-0.3-0.8-0.50.50.8
BMI with tail8.427.140.1-4.3-4.36.35.96.0-6.0-2.4
BMI without tail0.91.83.3-0.3-0.21.71.41.8-1.7-1.1
Body weight0.52.35.02.22.21.40.21.3-0.8-1.4
Weight adjusted by age0.60.71.10.60.6-1.0-1.0-1.10.90.0
Bone surface0.20.30.80.00.10.70.50.9-0.8-0.2
Bone volume0.71.12.2-0.6-0.51.31.21.5-1.5-0.1
Breakpoint value in progressive ratio session3.74.16.31.91.9-2.5-2.4-2.51.80.3
Number of licking bursts0.10.10.3-0.2-0.3-0.4-0.1-0.30.20.5
Context. condit. distance diff. score0.30.31.0-0.1-0.10.30.40.7-0.6-1.0
Locomotion velocity, session 10.30.30.6-0.4-0.40.80.70.4-0.60.2
Locomotion distance, session 12.73.54.52.12.1-1.5-2.0-1.82.11.1
Locomotion velocity, session 21.41.63.41.81.8-0.9-1.3-1.11.1-0.1
Locomotion distance, session 23.14.35.82.42.3-1.8-2.3-2.12.30.8
Locomotion velocity, session 30.30.41.50.60.6-0.1-0.4-0.20.31.2
Locomotion distance, session 33.23.54.72.12.2-1.7-2.1-1.91.90.6
Stereotopy head waving bouts, day 33.64.35.8-2.0-2.02.12.42.3-2.4-0.5
Stereotopy head waving duration, day 32.22.63.7-1.3-1.31.91.91.9-1.9-0.3
Locomotion velocity, session 71.71.82.31.51.5-1.3-1.5-1.31.50.8
Locomotion distance, session 74.55.77.42.52.6-2.6-2.7-2.52.60.3
Stereotopy head waving bouts, day 70.80.91.6-1.3-1.30.71.00.7-0.9-0.4
Stereotopy head waving duration, day 70.40.51.2-1.1-1.10.50.70.3-0.5-0.2
Locomotion velocity, session 80.20.31.20.50.50.3-0.00.2-0.1-1.1
Locomotion distance, session 80.91.32.51.61.6-0.9-1.2-0.81.1-0.3
Degree of sensitization distance0.10.10.20.30.3-0.1-0.2-0.10.2-0.5
Degree of sensitization stereotypy0.30.31.1-1.0-1.0-0.30.1-0.30.1-0.0
Conditioned locomotion0.70.81.5-0.3-0.31.21.01.2-1.2-0.1
Cocaine response after cond. corrected3.94.47.9-1.3-1.22.52.42.8-2.8-0.1
Cocaine response after cond. not corrected2.12.34.4-0.6-0.61.81.72.1-2.1-0.0
Cocaine response before conditioning1.82.23.11.31.2-1.7-1.6-1.81.7-0.2
Saline control response0.40.52.7-0.1-0.1-0.6-0.4-0.50.61.6
Bone: connectivity density0.20.40.7-0.8-0.80.20.60.5-0.70.4
Bone: cortical apparent density3.44.59.80.50.5-3.1-2.2-3.02.61.0
Bone: cortical area0.00.10.20.40.30.10.00.2-0.1-0.2
Bone: cortical porosity0.40.50.7-0.6-0.60.80.80.7-0.70.6
Bone: cortical porosity0.30.40.8-0.3-0.30.80.60.6-0.60.9
Bone: cortical thickness0.30.40.60.70.7-0.7-0.7-0.70.7-0.1
Bone: cortical thickness1.11.21.61.31.3-1.2-1.2-1.11.00.6
Bone: cortical tissue density3.64.710.20.50.5-3.2-2.3-3.02.61.0
Condit. Reinf. active minus inactive responses0.10.10.5-0.0-0.0-0.4-0.2-0.30.1-0.7
Condit. Reinf. active-inactive response ratio0.30.30.6-0.7-0.60.40.60.3-0.6-0.7
Condit. Reinf. active responses0.00.10.1-0.4-0.4-0.3-0.0-0.20.0-0.1
Condit. Reinf. inactive responses0.20.31.2-0.2-0.2-0.6-0.3-0.50.31.1
Incentive salience index mean0.10.10.3-0.0-0.1-0.6-0.4-0.60.40.2
Condit. Reinf. lever presses0.50.71.3-0.0-0.1-1.0-0.8-1.11.11.0
Condit. Reinf. active minus inactive responses0.40.52.0-0.5-0.60.50.50.4-0.21.4
Condit. Reinf. active-inactive response ratio0.90.91.6-1.2-1.20.80.90.7-0.61.0
Condit. Reinf. active responses0.30.42.0-0.5-0.50.20.20.10.11.4
Condit. Reinf. inactive responses0.30.41.5-0.1-0.1-0.6-0.3-0.60.61.2
Condit. Reinf. lever presses0.60.81.90.60.6-0.8-0.8-0.91.01.4
Condit. Reinf. lever reinforcers received0.30.42.4-0.3-0.3-0.1-0.0-0.10.31.5
Conditioned reinforcement - actives1.61.62.3-1.4-1.51.31.41.2-1.30.7
Conditioned reinforcement - inactives0.70.82.4-0.5-0.6-0.8-0.5-0.80.81.5
Conditioned locomotion3.74.57.0-1.9-1.92.72.42.3-2.30.7
Patch foraging indifference point 0 sec0.81.42.6-0.6-0.71.21.21.3-1.31.6
Patch foraging indifference point AUC0.20.20.8-0.1-0.2-0.5-0.3-0.40.3-0.9
Delay disc. indifference point, 0s delay1.01.11.90.70.7-1.0-1.1-1.31.01.4
Delay disc. indifference point, 16s delay0.20.20.50.40.40.70.30.7-0.2-0.2
Delay disc. indifference point, 2s delay1.11.24.21.01.0-0.3-0.8-0.80.82.1
Delay disc. indifference point, 24s delay0.50.40.90.91.0-0.5-0.7-0.30.5-0.5
Delay disc. indifference point, 4s delay4.44.77.62.82.7-1.9-2.4-2.01.61.3
Delay disc. indifference point, 8s delay0.10.10.30.50.5-0.1-0.3-0.10.00.5
Indifference point function ln k0.10.10.20.40.50.20.00.3-0.20.4
Indifference point function log k0.10.10.20.40.50.20.00.3-0.20.4
Patch foraging total patch changes 0 sec0.71.22.0-0.4-0.41.21.11.3-1.31.4
Patch foraging total patch changes 12 sec0.91.14.4-0.9-1.00.40.80.7-0.82.1
Patch foraging total patch changes 18 sec1.62.02.6-1.6-1.61.51.51.3-1.31.0
Patch foraging total patch changes 24 sec1.01.32.1-1.0-1.01.21.31.2-1.50.3
Patch foraging total patch changes 6 sec1.01.51.8-1.2-1.21.21.31.3-1.21.0
Patch foraging time to switch 0 sec0.20.30.7-0.6-0.60.30.50.3-0.40.8
Patch foraging water rate 0 sec0.50.92.50.40.41.00.51.1-0.8-1.6
Patch foraging water rate 12 sec0.50.81.81.31.2-0.2-0.7-0.30.5-1.2
Patch foraging water rate 18 sec0.81.11.91.41.3-0.9-1.1-0.91.0-0.4
Patch foraging water rate 24 sec0.30.51.2-0.2-0.31.10.70.9-0.7-0.3
Patch foraging water rate 6 sec0.10.20.80.0-0.1-0.2-0.2-0.30.4-0.9
Seeking ratio, delayed vs. immediate footshock0.30.40.6-0.8-0.80.30.80.6-0.3-0.5
Distance traveled before self-admin0.50.60.80.80.9-0.7-0.9-0.80.50.7
Distance traveled after self-admin1.41.53.0-0.1-0.11.41.01.3-1.7-1.7
Extensor digitorum longus weight0.31.12.51.51.50.8-0.20.6-0.1-1.6
Bone: elastic displacement0.10.10.4-0.2-0.20.60.40.3-0.30.4
Bone: elastic work0.10.20.50.70.70.3-0.10.20.0-0.2
Bone: endosteal estimation0.30.61.10.60.60.90.41.0-0.9-0.9
Bone: endosteal perimeter0.20.51.20.20.10.90.61.1-1.0-0.4
Epididymis fat weight0.10.30.60.70.70.3-0.2-0.20.3-0.7
Delta time in closed arm before/after self-admin0.20.20.80.50.5-0.1-0.2-0.2-0.4-0.9
Delta time in open arm before/after self-admin0.20.20.4-0.3-0.3-0.5-0.3-0.30.60.4
Diff in mean of infusions in LGA sessions0.40.41.5-0.1-0.1-1.0-0.6-1.20.1-0.1
Delay discount exponential model param0.80.82.0-1.4-1.40.30.90.5-0.5-0.7
Extinction: sum of active levers before priming1.41.43.61.21.2-0.9-1.0-0.90.8-1.9
Active lever presses in extinction session 60.40.41.9-0.2-0.20.20.40.3-0.5-1.4
Bone: final force0.10.20.4-0.1-0.20.50.50.6-0.5-0.1
Bone: final moment0.10.20.4-0.1-0.10.60.50.7-0.60.2
Food consumed during 24 hour testing period0.91.11.71.00.9-1.3-1.2-1.21.20.2
Glucose0.30.41.00.60.51.00.50.8-0.6-0.1
Heart weight0.71.02.9-0.1-0.11.20.91.2-0.9-1.7
Delay discount hyperbolic model param1.11.22.4-1.6-1.50.51.10.8-0.7-1.0
Intermittent access intake day 1-15 change1.61.62.6-0.9-0.81.61.31.4-1.3-1.2
Intermittent access intake escalation1.71.62.7-1.1-0.91.61.41.5-1.4-0.7
Intermittent access intake escalation 21.31.32.1-0.8-0.71.51.21.3-1.1-1.2
Intermitt. access day 1 inactive lever presses0.40.41.2-0.3-0.4-0.7-0.4-0.60.71.1
Intermitt. access day 15 inactive lever presses1.61.74.1-2.0-2.00.21.00.5-0.61.5
Intermitt. access escalation Index1.91.63.7-0.4-0.51.61.41.7-1.90.0
Intermittent access day 1 total infusions0.10.20.70.20.1-0.5-0.3-0.20.2-0.8
Intermittent access day 15 total infusions0.40.40.8-0.4-0.50.60.60.6-0.8-0.9
Intermittent access terminal intake (last 3 days)0.40.40.6-0.7-0.80.50.60.5-0.8-0.6
Intermittent access total infusions0.20.21.30.0-0.10.10.20.2-0.5-1.1
Intermittent access day 1 locomotion0.10.10.10.20.1-0.3-0.3-0.30.10.2
Intermittent access day 15 total locomotion0.50.61.6-0.6-0.60.50.70.6-0.7-1.3
Intermittent access total locomotion0.60.71.0-0.7-0.71.01.01.0-1.0-0.5
Intermittent access standard deviation1.21.32.0-0.8-0.71.31.21.4-1.4-0.9
Left kidney weight1.33.510.13.23.1-0.2-1.2-0.00.6-1.8
Right kidney weight0.61.53.11.71.61.00.11.0-0.5-1.8
Cocaine induced anxiety0.10.10.30.20.10.20.00.3-0.2-0.5
Post-drug Anxiety0.50.51.0-0.5-0.5-0.8-0.5-0.80.91.0
Baseline Anxiety1.21.33.6-1.6-1.6-0.20.4-0.30.21.9
Tail length11.033.351.67.27.2-5.5-6.4-5.35.50.3
Length with tail8.932.758.97.77.6-4.8-6.2-4.75.3-0.1
Length without tail0.91.94.92.22.1-0.6-1.3-0.81.2-0.5
Times rat made contact with spout0.10.10.4-0.3-0.4-0.30.0-0.20.10.6
Lifetime Intake0.10.10.70.0-0.1-0.00.10.1-0.4-0.9
Liver weight, left0.81.31.71.11.1-1.2-1.3-1.21.3-0.9
Liver weight, right2.03.36.62.62.6-1.5-1.8-1.41.5-0.4
Locomotor activity0.91.52.6-1.6-1.60.81.31.0-1.20.5
Locomotor testing distance2.13.57.1-2.7-2.71.21.91.4-1.60.7
Locomotor testing rearing0.71.03.3-1.8-1.80.00.70.1-0.4-0.2
Locomotion in novel chamber0.50.61.20.60.6-1.1-0.9-1.10.7-0.4
Locomotion in novel chamber post-restriction2.22.63.9-2.0-1.81.61.71.5-1.61.0
Fecal boli incidents, locomotor time 11.82.03.2-1.2-1.31.61.61.8-1.4-0.6
Change in fecal boli incidents, locomotor task1.61.52.31.21.3-1.5-1.5-1.41.0-0.1
Time >=10cm from walls, locomotor time 10.10.10.3-0.5-0.4-0.5-0.1-0.30.10.1
Bouts of movement, locomotor time 10.10.10.20.30.30.10.10.40.30.1
Total resting periods, locomotor time 10.10.10.30.50.50.20.10.60.30.1
Rest time, locomotor task time 10.50.52.90.30.30.40.30.7-0.01.7
Distance moved, locomotor task time 10.60.71.40.70.7-1.2-1.0-1.00.3-0.6
Vertical activity count, locomotor time 10.60.63.60.20.2-0.6-0.4-0.4-0.3-1.9
Time >=10cm from walls, locomotor time 20.30.30.70.20.2-0.8-0.6-0.80.70.4
Bouts of movement, locomotor time 20.10.10.3-0.5-0.50.40.40.4-0.1-0.1
Total resting periods, locomotor time 20.20.20.3-0.6-0.60.40.40.5-0.10.2
Rest time, locomotor task time 20.60.71.40.10.2-1.2-0.9-0.91.21.0
Distance moved, locomotor task time 20.70.82.51.61.5-0.3-0.7-0.40.1-0.3
Vertical activity count, locomotor time 20.60.61.51.21.20.3-0.10.3-0.7-0.9
Light reinforcement 11.01.94.2-2.1-2.00.81.30.7-0.91.2
Light reinforcement 20.10.20.3-0.5-0.50.20.40.3-0.40.4
Bone: marrow area0.20.50.80.60.60.70.30.9-0.7-0.9
Bone: maximum diameter0.30.50.9-0.2-0.40.80.80.9-0.9-0.2
Bone: maximum force0.40.71.30.30.31.00.71.1-0.9-1.1
Bone: maximum moment0.40.71.30.40.41.10.71.1-0.9-0.8
Mean time between licks in bursts0.10.10.2-0.0-0.00.40.20.4-0.20.3
Mean num. licks in bursts0.00.00.10.20.2-0.2-0.3-0.20.20.2
Cd content in liver0.40.40.80.20.3-0.9-0.7-0.80.70.0
Co content in liver0.10.10.50.30.30.1-0.00.2-0.2-0.7
Cu content in liver1.11.32.30.70.6-1.5-1.3-1.51.30.7
Fe content in liver1.62.03.11.81.8-1.3-1.6-1.31.4-0.2
K content in liver0.10.10.1-0.00.00.30.30.3-0.4-0.1
Mg content in liver0.50.50.80.20.3-0.9-0.7-0.90.80.8
Mn content in liver1.21.43.00.0-0.0-1.7-1.2-1.71.50.3
Na content in liver1.11.11.7-1.3-1.31.01.10.8-0.91.0
Rb content in liver0.70.93.8-1.1-1.0-0.20.1-0.30.32.0
Se content in liver0.10.10.1-0.3-0.30.30.40.3-0.3-0.3
Sr content in liver1.81.72.31.51.5-1.3-1.5-1.31.3-0.2
Zn content in liver0.60.73.1-0.9-0.90.20.3-0.0-0.01.7
Bone: minimum diameter0.20.41.11.00.90.2-0.20.3-0.1-1.1
Time in familiar zone, hab. session 10.50.50.8-0.7-0.7-0.9-0.3-0.70.4-0.9
Time in novel zone, hab. session 12.12.13.2-1.0-1.01.81.61.8-1.61.0
Total zone transitions, hab. session 15.07.09.92.52.3-2.9-3.1-3.03.10.7
Total locomotion distance, hab. session 11.92.74.21.31.2-1.9-1.8-1.82.01.2
Locomotion velocity, hab. session 13.04.25.82.02.0-2.1-2.3-2.22.41.0
Time in familiar zone, hab. session 20.60.71.6-1.2-1.30.60.80.4-0.6-0.3
Time in novel zone, hab. session 20.30.30.70.70.7-0.2-0.30.00.20.8
Total zone transitions, hab. session 21.11.42.20.90.8-1.4-1.4-1.51.50.3
Total locomotion distance, hab. session 20.10.10.30.20.1-0.0-0.1-0.10.30.6
Locomotion velocity, hab. session 20.10.10.40.60.5-0.1-0.3-0.20.40.3
Novel to familiar place preference ratio1.41.52.71.61.6-1.0-1.2-0.80.8-1.1
Novelty place preference1.51.52.71.61.7-1.1-1.2-0.90.8-1.0
Time in novel zone, NPP test1.01.11.81.31.3-1.0-1.1-0.70.7-0.9
Total zone transitions, NPP test2.83.96.61.71.6-2.0-2.2-2.32.61.1
Total locomotion distance, NPP test0.81.12.10.70.7-0.8-1.0-1.11.51.3
Locomotion velocity, NPP test1.41.93.21.31.3-1.1-1.5-1.41.81.2
Intraocular pressure1.42.03.21.61.8-1.4-1.4-0.90.9-1.6
Delta distance traveled before/after self-admin2.93.15.3-1.2-1.11.91.81.9-1.9-2.3
Delta ambulatory time before/after self-admin2.52.74.1-1.1-1.12.01.81.9-1.7-1.7
Parametrial fat weight0.30.52.7-0.3-0.30.30.40.5-0.61.6
Pavlov. Cond. lever latency1.21.53.30.00.11.31.01.5-1.5-1.8
Pavlov. Cond. magazine entry latency0.30.41.2-1.0-1.1-0.10.40.1-0.20.6
Pavlov. Cond. change in total contacts1.01.12.6-0.2-0.2-1.6-1.0-1.51.20.1
Pavlov. Cond. index score0.50.71.8-0.8-0.9-0.8-0.3-0.80.61.3
Pavlov. Cond. latency score0.60.72.2-0.5-0.6-0.8-0.4-0.90.81.5
Pavlov. Cond. lever contacts1.21.42.5-0.0-0.1-1.4-1.1-1.61.51.4
Pavlov. Cond. magazine entry number0.70.92.31.51.50.5-0.20.4-0.2-0.9
Pavlov. Cond. intertrial magazine entries0.50.71.21.01.1-0.8-0.9-0.70.70.1
Pavlov. Cond. lever-magazine prob. diff.0.50.61.6-0.9-0.9-0.7-0.2-0.70.51.3
Pavlov. Cond. response bias0.60.71.2-1.0-1.1-0.7-0.2-0.80.61.1
Pavlov. Cond. lever latency0.50.60.90.70.8-1.0-0.9-0.80.7-0.5
Pavlov. Cond. magazine entry latency0.60.71.31.11.1-0.7-0.9-0.80.80.1
Pavlov. Cond. change in total contacts0.20.30.4-0.6-0.50.60.60.6-0.40.7
Pavlov. Cond. index score0.10.20.50.00.00.70.50.5-0.40.1
Pavlov. Cond. latency score0.10.10.20.30.40.50.20.3-0.20.0
Pavlov. Cond. lever contacts0.40.60.8-0.7-0.70.80.90.8-0.70.8
Pavlov. Cond. magazine entry number0.10.20.4-0.6-0.7-0.10.1-0.1-0.1-0.5
Pavlov. Cond. intertrial magazine entries1.21.52.60.70.7-1.6-1.5-1.61.60.4
Pavlov. Cond. lever-magazine prob. diff.0.20.20.60.10.10.80.50.6-0.40.1
Pavlov. Cond. response bias0.40.60.9-0.5-0.50.90.80.8-0.61.0
Time in closed arm before self-admin1.41.56.2-1.0-1.01.00.90.7-0.42.5
Time in closed arm after self-admin0.30.30.8-0.1-0.10.80.50.5-0.80.9
Time in open arm before self-admin0.30.32.00.30.3-0.2-0.1-0.2-0.1-1.4
Time in open arm after self-admin0.20.20.5-0.4-0.4-0.6-0.3-0.50.7-0.4
Bone: periosteal estimation0.20.40.90.30.20.80.61.0-0.8-0.6
Bone: periosteal perimeter0.20.30.60.40.30.60.40.7-0.6-0.6
Bone: post-yield work0.30.41.20.40.40.30.30.7-0.6-1.1
Progressive ratio test 1 active lever presses0.10.20.50.60.5-0.1-0.1-0.1-0.10.7
Progressive ratio test 1 breakpoint0.30.30.60.70.7-0.4-0.4-0.30.20.8
Progressive ratio test 1 inactive lever presses0.20.31.1-0.4-0.50.20.30.3-0.31.1
Progressive ratio test 2 active lever presses0.00.00.1-0.3-0.4-0.20.1-0.1-0.0-0.1
Progressive ratio test 2 breakpoint0.10.10.6-0.3-0.3-0.10.20.0-0.1-0.8
Progressive ratio test 2 inactive lever presses0.10.20.5-0.4-0.5-0.4-0.1-0.30.1-0.7
Incentive Sensitization - Responses0.10.10.4-0.5-0.60.10.30.1-0.1-0.4
Incentive Sensitization - Breakpoint0.20.20.4-0.5-0.70.30.50.4-0.3-0.6
Sum of active levers in priming session hrs 5-63.02.94.81.11.1-2.0-1.7-2.11.2-2.2
Progressive ratio1.01.14.60.50.5-0.6-0.7-1.00.92.1
Food seeking constrained by brief footshock0.40.50.8-0.5-0.60.90.90.9-0.7-0.1
Seeking ratio, punishment vs. effort1.31.56.5-0.4-0.40.70.91.2-1.1-2.5
Retroperitoneal fat weight0.20.81.51.10.81.20.51.1-0.70.4
Reaction time number correct0.30.40.80.30.4-0.3-0.6-0.50.90.9
Reaction time mean minus median0.40.52.7-0.5-0.5-0.5-0.1-0.30.21.6
Reaction time mean minus median AUC0.91.15.8-0.8-0.8-0.6-0.1-0.50.32.4
Reaction time num false alarms0.10.20.4-0.2-0.2-0.4-0.4-0.60.6-0.2
Reaction time num false alarms AUC0.20.20.60.00.1-0.5-0.5-0.70.70.3
Reaction time trials correct on left0.30.40.80.30.4-0.3-0.6-0.50.90.9
Reaction time trials on left0.30.40.80.30.4-0.3-0.6-0.50.90.9
Reaction time mean0.60.91.6-1.3-1.30.30.80.6-0.81.1
Reaction time mean AUC0.50.71.3-1.1-1.10.20.70.5-0.70.9
Median of all reaction times0.91.22.5-1.6-1.60.61.10.8-1.10.7
Reaction time omissions0.10.10.3-0.3-0.30.10.30.3-0.40.6
Reaction time false alarm rate0.00.00.1-0.2-0.2-0.1-0.0-0.20.1-0.3
Reaction time premature initiation rate0.60.83.40.60.6-0.6-0.6-0.60.51.8
Reaction time premature initiations1.01.34.40.80.9-0.8-1.0-1.01.12.1
Std. dev. reaction times0.30.52.8-0.4-0.4-0.30.1-0.10.01.7
Reaction time trials completed0.30.40.80.30.4-0.3-0.6-0.50.90.9
Reaction time trials AUC0.30.40.80.30.3-0.3-0.6-0.60.90.9
Run reversals in cocaine runway, females0.90.93.21.01.3-0.2-0.6-0.3-0.3-1.8
Run reversals in cocaine runway, males2.22.15.5-2.4-2.40.91.30.7-0.70.2
Latency to leave start box in cocaine runway1.51.62.9-0.8-0.81.71.41.5-1.4-0.9
Latency to leave start box in cocaine runway, F2.32.55.5-0.8-0.82.41.82.1-1.70.1
Latency to leave start box in cocaine runway, M1.31.26.4-0.5-0.50.50.70.6-0.8-2.5
Std. dev. time between licks in bursts0.91.11.6-1.0-1.01.21.21.3-1.2-0.0
Total sessions with >9 infusions0.40.50.8-0.3-0.30.80.80.9-0.9-0.6
Short access day 1 total inactive lever presses2.02.24.70.20.2-2.2-1.6-2.11.90.5
Short access day 10 total inactive lever presses1.01.12.6-0.1-0.1-1.2-0.8-1.11.31.6
Short access day 1 total infusions0.00.00.2-0.3-0.4-0.10.10.0-0.1-0.1
Short access day 10 total infusions0.60.62.4-0.2-0.30.50.60.7-0.9-1.5
Short access total infusions0.10.10.30.10.00.10.10.3-0.4-0.5
Short access day 1 locomotion0.60.61.0-0.6-0.71.00.90.9-0.90.2
Short access day 10 total locomotion0.30.30.6-0.6-0.30.80.60.6-0.40.6
Short access total locomotion0.50.51.1-0.4-0.31.00.80.9-0.70.4
One hour access (0.3 mA shock)0.30.30.80.10.1-0.9-0.6-0.90.50.1
Compulsive drug intake5.45.48.11.91.8-2.8-2.6-2.82.41.6
One hour access (shock baseline)2.12.43.1-1.5-1.51.71.71.7-1.8-1.0
Social response proportion1.41.52.81.41.6-1.0-1.1-0.60.91.7
Social responses0.00.10.20.20.3-0.2-0.10.00.10.5
Social time0.30.41.1-1.0-1.1-0.20.4-0.0-0.30.1
Soleus weight0.61.83.6-0.7-0.71.91.51.6-1.40.8
Bone: stiffness0.10.10.30.40.40.20.10.4-0.4-0.6
Tibialis anterior weight0.31.11.91.41.3-0.7-1.1-0.91.2-0.1
Time to tail flick, vehicle, before self-admin1.01.02.60.30.3-1.6-1.1-1.40.9-0.5
Time to tail flick, vehicle, after self-admin0.10.20.4-0.5-0.50.20.40.3-0.6-0.1
Time to tail flick, test, before self-admin0.40.42.4-0.1-0.1-0.10.10.2-0.2-1.5
Time to tail flick, test, after self-admin0.50.52.80.30.30.30.20.4-0.5-1.7
Delta time to tail flick, vehicle, before/after SA0.90.91.4-0.7-0.71.21.11.2-1.00.3
Delta time to tail flick, test, before/after SA0.40.30.70.80.8-0.2-0.4-0.40.20.8
Tibia length0.30.91.80.80.81.10.51.1-0.8-1.3
Ambulatory time before self-admin0.30.40.50.60.7-0.4-0.7-0.60.60.4
Ambulatory time after self-admin1.82.04.70.10.21.71.11.5-1.6-2.2
Bone: tissue strength0.10.10.2-0.2-0.20.30.40.4-0.4-0.5
Total heroin consumption1.01.22.60.20.2-1.6-1.1-1.51.0-0.9
Bone: trabecular number0.91.42.5-1.6-1.60.91.31.0-1.10.5
Bone: trabecular spacing0.00.10.2-0.2-0.20.0-0.1-0.30.40.2
Bone: trabecular thickness0.80.91.90.00.01.31.01.3-1.4-0.3
Bone: trabecular tissue density0.20.31.00.30.3-0.3-0.4-0.60.71.0
Water consumed over 24 hours0.30.31.4-0.0-0.1-0.6-0.3-0.50.51.2
Number of responses in last shaping day0.20.20.9-0.5-0.50.10.30.3-0.1-0.9