Hub : Genes

Kpna2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Kpna2 0.13 0.06 7.4e-10 0.06 0.07 0.05 0.06 3.0e-07 6.8e-08 1.4e-06 8.6e-07
2 BLA gene expression Kpna2 0.08 0.05 3.2e-04 0.07 0.06 0.07 0.07 1.6e-04 3.0e-04 1.9e-04 1.6e-04
3 Liver mRNA stability Kpna2 0.04 0.02 5.9e-04 0.01 0.01 0.01 0 2.0e-02 8.7e-03 1.6e-02 9.3e-02
4 Adipose mRNA stability Kpna2 0.04 0.02 3.4e-04 0.02 0.02 0.02 0.02 1.1e-03 1.5e-03 2.6e-03 5.2e-03
5 NAcc gene expression Kpna2 0.18 0.07 0.0e+00 0.22 0.2 0.22 0.22 1.2e-24 3.8e-23 2.1e-25 3.0e-25
6 Brain gene expression Kpna2 0.24 0.11 1.7e-14 0.14 0.13 0.16 0.15 4.2e-13 2.3e-12 2.7e-14 4.9e-14
7 IL gene expression Kpna2 0.29 0.12 4.3e-05 0.11 0.09 0.13 0.07 1.2e-03 3.5e-03 5.3e-04 8.7e-03
8 Adipose gene expression Kpna2 0.32 0.1 0.0e+00 0.34 0.34 0.36 0.35 2.4e-39 3.9e-39 2.1e-42 7.0e-41
9 Eye gene expression Kpna2 0.43 0.16 2.3e-03 0.06 0.1 0.21 0.04 5.2e-02 1.5e-02 3.8e-04 9.6e-02
10 PL gene expression Kpna2 0.13 0.05 4.1e-13 0.05 0.12 0.12 0.11 7.3e-06 6.4e-13 9.9e-13 1.8e-12
11 Brain isoform ratio NM_001270802.1 0.08 0.05 7.4e-04 0.02 0.02 0.02 0 6.3e-03 5.1e-03 8.0e-03 1.8e-01
12 Brain isoform ratio NM_053483.2 0.09 0.05 5.9e-04 0.02 0.02 0.02 0 5.6e-03 3.3e-03 4.1e-03 1.7e-01
13 LHb gene expression Kpna2 0.19 0.09 2.5e-03 0.08 0.11 0.11 0.11 6.6e-03 1.7e-03 1.6e-03 1.8e-03
14 pVTA gene expression Kpna2 0.12 0.07 3.5e-03 0.1 0.05 0.08 0.09 6.7e-05 3.4e-03 2.8e-04 1.0e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.61.02.50.60.91.4-1.61.11.50.70.61.5-0.90.2-0.20.70.9
Area under the delay curve0.90.92.50.3-0.20.8-1.00.60.9-0.3-0.31.6-1.2-1.21.21.01.6
BMI with tail1.03.310.43.20.61.51.40.42.42.5-1.00.2-1.8-1.71.71.42.6
BMI without tail2.75.519.44.41.92.90.41.83.03.1-0.0-0.6-2.6-1.61.62.52.1
Body weight1.76.919.54.43.03.6-2.12.93.93.50.6-0.6-2.6-0.20.22.21.7
Weight adjusted by age0.60.71.5-0.6-1.2-0.60.2-0.8-1.1-1.0-1.01.0-0.0-0.80.8-0.1-1.0
Bone surface2.44.314.51.12.92.5-3.82.72.51.52.00.4-1.01.9-1.91.00.2
Bone volume2.13.610.51.52.52.6-3.22.52.61.41.60.9-1.31.2-1.21.10.8
Breakpoint value in progressive ratio session0.40.51.00.4-0.5-0.2-0.8-0.1-0.3-0.6-0.2-0.90.80.8-0.8-1.0-1.0
Number of licking bursts0.20.20.6-0.5-0.0-0.4-0.8-0.2-0.4-0.3-0.4-0.20.50.7-0.7-0.5-0.5
Context. condit. distance diff. score0.10.10.3-0.0-0.1-0.10.4-0.2-0.2-0.1-0.1-0.50.50.5-0.5-0.4-0.0
Locomotion velocity, session 10.30.30.90.80.30.8-0.80.70.90.30.10.9-0.50.1-0.10.3-0.0
Locomotion distance, session 10.50.72.11.10.41.1-0.40.61.20.2-0.41.4-0.9-0.30.31.00.5
Locomotion velocity, session 21.21.46.60.30.3-0.3-0.6-0.1-0.4-0.6-0.0-0.71.42.0-2.0-1.3-2.6
Locomotion distance, session 20.40.52.10.5-0.3-0.1-0.7-0.3-0.2-0.6-1.10.50.61.0-1.0-0.5-1.4
Locomotion velocity, session 30.81.03.40.3-1.6-0.60.0-1.1-0.4-1.4-1.81.10.80.5-0.6-1.2-0.3
Locomotion distance, session 30.50.61.4-0.1-0.6-0.1-0.9-0.4-0.1-1.2-0.71.20.61.0-1.0-0.9-0.5
Stereotopy head waving bouts, day 30.40.51.3-0.4-1.1-0.40.5-0.5-0.2-0.4-0.70.5-0.3-1.11.10.11.1
Stereotopy head waving duration, day 30.40.51.3-0.2-1.0-0.30.0-0.5-0.2-0.8-1.00.6-0.2-1.01.0-0.11.1
Locomotion velocity, session 70.20.20.7-0.6-0.3-0.60.8-0.7-0.40.1-0.10.40.50.3-0.3-0.5-0.4
Locomotion distance, session 70.00.00.10.10.30.20.10.20.10.1-0.1-0.1-0.10.1-0.10.3-0.3
Stereotopy head waving bouts, day 71.01.12.7-0.5-1.7-1.20.1-1.3-1.1-1.4-1.5-0.41.20.4-0.4-1.3-0.3
Stereotopy head waving duration, day 72.83.46.4-1.7-2.5-2.30.2-2.2-2.3-2.5-1.9-0.32.20.8-0.9-2.2-1.0
Locomotion velocity, session 80.30.41.10.10.50.3-0.70.40.30.30.80.10.31.1-1.0-0.4-0.9
Locomotion distance, session 80.20.31.10.50.20.2-0.4-0.1-0.1-0.2-0.2-0.10.51.0-1.0-0.5-0.9
Degree of sensitization distance0.80.82.50.30.90.80.11.00.61.30.8-0.7-1.0-0.90.91.60.2
Degree of sensitization stereotypy2.32.64.6-0.6-1.9-1.80.5-1.8-1.7-1.9-1.8-1.02.11.4-1.4-2.0-1.3
Conditioned locomotion0.30.40.70.80.40.6-0.20.70.30.80.5-0.8-0.7-0.70.70.8-0.0
Cocaine response after cond. corrected0.50.62.6-1.6-0.7-0.7-0.6-0.7-0.7-0.8-0.71.20.1-0.40.40.00.2
Cocaine response after cond. not corrected1.71.95.6-2.4-1.1-1.6-0.8-1.5-1.8-1.7-1.10.51.40.9-0.9-1.3-1.1
Cocaine response before conditioning1.41.73.5-0.5-0.5-1.0-0.3-1.2-1.2-1.5-0.8-0.71.81.9-1.9-1.9-1.4
Saline control response0.91.28.72.20.50.80.20.80.51.20.5-2.9-0.2-0.20.20.1-0.2
Bone: connectivity density0.81.34.30.61.21.5-2.11.51.50.80.81.2-0.90.6-0.60.80.2
Bone: cortical apparent density1.72.25.2-0.2-1.6-0.92.3-1.6-0.1-0.5-2.02.3-0.3-1.51.5-0.12.3
Bone: cortical area1.82.78.83.01.92.3-1.51.42.71.50.00.7-1.10.9-0.90.61.8
Bone: cortical porosity2.83.17.61.22.00.7-2.00.90.20.41.3-2.51.22.8-2.7-1.3-2.4
Bone: cortical porosity1.71.95.01.41.70.8-1.90.60.4-0.00.4-1.50.82.2-2.2-1.0-1.6
Bone: cortical thickness1.93.212.21.4-1.9-0.72.2-2.40.4-0.5-3.52.80.1-0.80.7-0.92.4
Bone: cortical thickness1.41.75.10.4-0.8-1.12.1-2.1-0.5-0.5-2.31.61.10.8-0.8-1.40.3
Bone: cortical tissue density1.62.15.5-0.2-1.6-0.92.3-1.6-0.2-0.5-1.92.1-0.2-1.51.5-0.12.2
Condit. Reinf. active minus inactive responses1.21.45.31.71.91.2-1.11.20.50.00.9-2.30.11.0-1.0-0.1-0.5
Condit. Reinf. active-inactive response ratio0.50.62.80.40.90.4-0.70.5-0.3-0.30.6-1.70.51.0-1.0-0.5-0.7
Condit. Reinf. active responses1.61.95.52.12.31.7-1.61.61.00.51.1-2.2-0.40.9-0.90.2-0.4
Condit. Reinf. inactive responses1.11.32.81.51.71.6-1.41.41.50.80.6-0.1-1.2-0.10.10.90.5
Incentive salience index mean1.21.45.51.41.70.8-1.30.90.30.20.7-2.30.51.4-1.4-0.6-0.8
Condit. Reinf. lever presses0.60.73.10.60.3-0.4-0.5-0.3-0.6-0.2-0.2-1.81.11.1-1.1-1.3-0.9
Condit. Reinf. active minus inactive responses2.53.112.92.02.22.0-3.61.71.30.00.3-1.40.02.3-2.3-0.2-1.0
Condit. Reinf. active-inactive response ratio1.21.25.20.51.20.7-2.30.90.1-0.20.5-1.40.51.5-1.5-0.6-1.3
Condit. Reinf. active responses2.94.010.03.03.02.7-3.22.41.90.91.1-1.6-0.61.8-1.80.5-0.6
Condit. Reinf. inactive responses2.12.610.33.22.42.4-1.01.92.21.30.7-0.6-1.20.5-0.51.10.5
Condit. Reinf. lever presses1.41.95.92.42.11.2-1.00.80.80.70.4-2.20.31.7-1.7-0.3-0.8
Condit. Reinf. lever reinforcers received2.53.58.42.72.82.5-2.92.31.90.91.1-1.4-0.71.6-1.60.6-0.4
Conditioned reinforcement - actives0.20.21.20.90.20.5-0.50.30.10.2-0.0-1.1-0.3-0.30.30.0-0.4
Conditioned reinforcement - inactives1.21.33.31.71.51.8-0.71.51.81.01.0-0.5-1.10.3-0.30.90.0
Conditioned locomotion1.61.94.22.11.81.9-1.21.91.71.61.0-0.9-1.4-0.30.31.10.3
Patch foraging indifference point 0 sec3.65.814.43.83.63.5-2.13.03.22.31.3-1.1-2.20.2-0.21.91.1
Patch foraging indifference point AUC1.11.33.11.50.81.5-1.11.81.71.31.00.6-1.00.0-0.00.90.6
Delay disc. indifference point, 0s delay0.40.51.9-0.8-0.9-0.4-0.3-0.3-0.5-0.7-0.61.4-0.3-0.90.90.30.2
Delay disc. indifference point, 16s delay1.21.24.70.8-0.11.0-1.00.61.00.2-0.60.9-1.3-1.41.41.12.2
Delay disc. indifference point, 2s delay1.31.55.60.11.01.4-2.41.31.20.20.31.8-1.5-0.60.61.40.9
Delay disc. indifference point, 24s delay2.82.85.02.21.12.2-1.41.62.21.60.10.7-2.1-1.31.31.82.0
Delay disc. indifference point, 4s delay0.60.62.0-1.0-1.1-0.8-0.1-0.7-0.7-1.4-0.81.40.4-0.10.1-0.40.2
Delay disc. indifference point, 8s delay1.01.04.00.1-0.80.4-0.20.10.6-0.4-0.72.0-1.0-1.51.50.91.6
Indifference point function ln k0.40.62.20.1-0.1-0.50.3-1.3-0.7-1.0-1.50.40.70.5-0.5-1.0-0.1
Indifference point function log k0.40.62.20.1-0.1-0.50.3-1.3-0.7-1.0-1.50.40.70.5-0.5-1.0-0.1
Patch foraging total patch changes 0 sec3.55.713.33.63.43.5-2.33.13.22.31.3-0.9-2.30.1-0.12.11.1
Patch foraging total patch changes 12 sec4.05.212.72.73.03.1-2.53.62.82.32.1-0.7-2.10.1-0.12.00.6
Patch foraging total patch changes 18 sec1.82.36.32.51.72.0-1.32.32.11.51.0-1.3-1.10.4-0.41.00.1
Patch foraging total patch changes 24 sec3.54.39.93.12.53.1-2.12.92.91.80.80.2-2.2-0.10.11.81.0
Patch foraging total patch changes 6 sec2.43.69.22.73.02.6-1.72.52.61.91.4-0.5-1.50.6-0.61.30.6
Patch foraging time to switch 0 sec0.40.71.5-1.2-0.9-1.21.0-0.8-1.2-0.50.1-0.80.7-0.20.2-0.6-1.1
Patch foraging water rate 0 sec1.72.86.22.52.22.5-0.71.82.32.11.00.3-1.8-0.20.21.81.1
Patch foraging water rate 12 sec0.40.53.2-0.1-0.1-0.40.5-1.20.1-0.5-1.81.10.30.3-0.3-0.30.7
Patch foraging water rate 18 sec0.40.52.30.30.80.2-0.9-0.80.1-0.3-1.50.90.10.8-0.8-0.50.3
Patch foraging water rate 24 sec0.20.31.3-0.40.1-0.2-0.8-0.7-0.3-0.8-1.10.50.30.4-0.4-0.4-0.2
Patch foraging water rate 6 sec0.20.31.50.50.00.2-0.1-0.60.20.0-1.20.8-0.4-0.30.30.10.8
Seeking ratio, delayed vs. immediate footshock0.30.41.21.10.40.61.00.40.50.40.3-0.4-0.6-0.70.70.50.3
Distance traveled before self-admin1.41.53.9-1.7-1.5-1.3-0.9-1.0-1.2-2.0-1.21.21.30.8-0.8-1.2-0.1
Distance traveled after self-admin1.71.83.4-1.1-1.2-1.2-1.0-0.7-1.3-1.8-1.0-0.71.81.7-1.7-1.8-1.0
Extensor digitorum longus weight1.55.919.4-0.5-1.7-0.64.2-0.3-0.01.70.91.2-1.8-4.44.41.93.3
Bone: elastic displacement1.11.33.8-0.6-1.1-1.30.9-2.0-1.0-1.3-1.80.91.10.5-0.5-1.3-0.7
Bone: elastic work0.30.42.11.00.70.40.5-0.20.90.8-0.31.4-0.20.4-0.4-0.20.4
Bone: endosteal estimation6.814.738.72.76.24.2-5.15.23.33.25.0-4.0-1.23.2-3.21.8-1.4
Bone: endosteal perimeter7.114.736.23.05.74.8-6.05.63.93.04.6-2.7-1.82.8-2.82.0-0.4
Epididymis fat weight1.84.39.91.91.02.10.32.12.33.21.30.2-2.7-2.32.32.71.9
Delta time in closed arm before/after self-admin0.40.41.7-0.8-0.0-0.3-0.50.0-0.3-0.40.3-0.10.50.9-0.9-0.4-1.3
Delta time in open arm before/after self-admin0.90.93.00.1-0.9-0.00.90.0-0.0-0.3-0.20.8-0.7-1.71.70.61.7
Diff in mean of infusions in LGA sessions0.70.82.4-0.0-1.2-1.01.6-1.4-0.8-0.3-1.10.60.6-0.30.3-0.8-0.1
Delay discount exponential model param0.90.92.2-0.4-0.1-1.01.2-0.8-1.00.00.0-1.41.21.0-1.0-1.1-1.5
Extinction: sum of active levers before priming0.30.30.70.80.30.6-0.20.70.70.50.1-0.1-0.6-0.60.60.40.6
Active lever presses in extinction session 60.80.72.11.51.11.0-0.41.21.10.91.0-0.9-0.40.3-0.30.20.4
Bone: final force1.11.94.91.42.21.6-1.81.11.91.00.10.9-0.61.5-1.50.31.2
Bone: final moment1.11.85.31.42.31.6-1.81.11.91.00.20.8-0.51.6-1.60.21.0
Food consumed during 24 hour testing period2.32.75.92.41.41.9-0.62.12.32.41.1-1.2-1.7-0.80.81.61.5
Glucose0.71.12.4-1.1-1.4-1.40.4-1.5-1.3-1.2-1.20.41.00.2-0.2-0.9-0.8
Heart weight0.10.21.00.5-0.40.3-0.3-0.2-0.1-0.7-1.00.6-0.3-0.40.40.20.4
Delay discount hyperbolic model param0.90.92.7-0.3-0.1-0.91.2-0.7-0.90.10.1-1.61.21.1-1.1-1.1-1.4
Intermittent access intake day 1-15 change0.50.52.6-0.70.5-0.30.40.4-0.20.81.6-1.40.30.3-0.30.00.1
Intermittent access intake escalation0.40.41.7-0.80.3-0.40.60.1-0.40.61.3-1.30.30.1-0.1-0.00.3
Intermittent access intake escalation 20.80.84.5-0.51.10.30.11.00.31.52.1-1.1-0.20.2-0.20.60.1
Intermitt. access day 1 inactive lever presses2.02.25.42.31.71.7-2.31.41.60.40.5-1.6-0.01.7-1.7-0.3-0.2
Intermitt. access day 15 inactive lever presses0.80.92.91.71.21.20.51.01.11.21.3-1.0-0.6-0.10.10.50.1
Intermitt. access escalation Index3.53.16.8-2.6-2.1-2.3-0.3-2.2-2.1-1.8-1.90.52.01.2-1.2-1.8-0.3
Intermittent access day 1 total infusions0.80.93.21.81.01.4-1.20.81.50.2-0.70.0-1.1-0.30.30.60.7
Intermittent access day 15 total infusions0.50.51.10.81.10.8-0.30.70.80.80.5-1.0-0.7-0.30.30.50.9
Intermittent access terminal intake (last 3 days)1.61.83.81.42.01.7-1.11.71.71.61.4-1.1-1.3-0.20.21.10.7
Intermittent access total infusions1.82.04.72.22.12.0-1.51.71.91.10.7-1.1-1.20.1-0.10.80.5
Intermittent access day 1 locomotion2.12.26.92.62.12.2-1.61.82.01.20.5-0.8-1.40.0-0.00.9-0.1
Intermittent access day 15 total locomotion3.53.89.62.53.12.5-1.72.52.32.21.8-2.2-1.50.4-0.41.20.3
Intermittent access total locomotion5.56.315.53.93.93.5-1.93.13.22.61.7-1.9-2.20.2-0.21.60.5
Intermittent access standard deviation1.21.32.71.71.21.30.31.41.41.31.3-0.8-1.0-0.30.30.81.5
Left kidney weight0.51.49.40.9-0.5-0.40.0-1.6-0.2-1.4-3.10.90.90.9-0.9-1.1-0.4
Right kidney weight0.31.06.40.6-0.1-0.3-0.6-1.00.1-0.9-2.50.90.71.1-1.1-0.90.2
Cocaine induced anxiety0.10.10.4-0.0-0.1-0.20.6-0.6-0.4-0.4-0.3-0.10.30.1-0.1-0.1-0.1
Post-drug Anxiety0.40.40.9-0.7-0.9-0.50.7-0.6-0.8-0.5-0.30.7-0.2-0.90.90.3-0.1
Baseline Anxiety0.60.61.8-0.8-1.4-0.70.6-0.7-0.7-0.3-0.81.0-0.3-1.21.20.20.1
Tail length1.13.46.92.32.22.6-2.02.62.12.11.7-0.9-1.9-0.20.22.00.4
Length with tail1.03.512.51.52.42.4-3.52.72.21.41.6-0.2-1.41.0-1.01.20.4
Length without tail0.30.64.5-0.70.70.2-2.10.80.50.20.60.30.00.9-0.9-0.2-0.5
Times rat made contact with spout0.30.30.70.50.60.6-0.60.90.80.90.7-0.5-0.30.3-0.30.40.2
Lifetime Intake2.12.47.92.82.22.3-1.51.82.11.10.5-1.4-1.30.2-0.20.70.4
Liver weight, left0.40.75.0-0.00.80.8-2.21.00.90.30.3-0.2-0.30.8-0.80.20.3
Liver weight, right0.50.93.9-0.2-0.10.5-0.6-0.11.00.1-1.12.0-1.0-0.60.60.91.8
Locomotor activity1.11.85.42.31.20.6-0.7-0.30.7-0.2-1.1-1.61.12.2-2.2-1.3-0.5
Locomotor testing distance1.11.99.03.01.10.9-0.50.20.7-0.0-0.7-2.30.91.8-1.8-1.1-0.7
Locomotor testing rearing1.42.29.71.70.8-0.00.60.1-0.00.30.4-3.11.72.2-2.2-1.5-1.6
Locomotion in novel chamber0.60.72.0-0.9-0.1-0.4-1.3-0.5-0.7-1.1-0.50.10.71.1-1.1-0.8-1.4
Locomotion in novel chamber post-restriction1.62.07.80.32.21.7-2.81.71.51.21.30.1-1.20.4-0.41.40.4
Fecal boli incidents, locomotor time 10.20.20.5-0.7-0.6-0.3-0.4-0.0-0.4-0.6-0.00.7-0.1-0.60.6-0.10.3
Change in fecal boli incidents, locomotor task0.80.81.60.70.30.71.00.60.90.80.20.6-1.2-1.31.31.20.9
Time >=10cm from walls, locomotor time 12.52.53.9-1.9-1.2-1.80.1-1.9-1.9-1.7-1.5-0.01.81.5-1.5-1.7-2.0
Bouts of movement, locomotor time 10.60.62.50.20.2-0.11.6-0.20.20.60.4-0.9-0.6-1.31.30.60.9
Total resting periods, locomotor time 10.70.72.4-0.00.1-0.01.5-0.10.30.70.5-0.5-0.8-1.41.40.81.2
Rest time, locomotor task time 10.30.31.2-1.1-0.6-0.60.4-0.3-0.5-0.20.20.2-0.1-0.80.80.20.4
Distance moved, locomotor task time 10.40.41.31.00.50.9-0.50.60.81.10.4-0.4-0.60.0-0.00.60.0
Vertical activity count, locomotor time 10.20.20.60.40.40.6-0.80.30.40.6-0.0-0.3-0.10.5-0.50.2-0.2
Time >=10cm from walls, locomotor time 21.31.43.9-1.4-0.7-1.50.6-1.2-1.4-0.1-0.2-0.71.51.2-1.2-1.3-2.0
Bouts of movement, locomotor time 20.60.62.20.3-0.6-0.21.5-0.20.10.7-0.0-0.4-0.4-1.21.20.51.2
Total resting periods, locomotor time 20.50.52.40.1-0.8-0.41.5-0.5-0.10.2-0.3-0.2-0.2-1.11.10.31.1
Rest time, locomotor task time 22.52.97.7-2.5-2.8-1.80.9-1.6-1.9-1.9-1.52.10.3-1.71.7-0.4-0.1
Distance moved, locomotor task time 20.70.84.00.70.50.10.30.20.41.40.7-2.00.51.1-1.1-0.3-0.7
Vertical activity count, locomotor time 21.61.85.22.01.61.1-0.21.11.32.11.3-2.30.01.2-1.20.1-0.0
Light reinforcement 11.01.76.52.60.31.30.00.71.41.1-1.00.3-1.5-1.61.61.01.8
Light reinforcement 21.62.13.81.80.11.6-0.41.01.60.80.01.6-2.0-1.91.91.51.9
Bone: marrow area6.614.237.52.56.14.1-5.05.13.13.24.9-4.0-1.13.2-3.21.7-1.4
Bone: maximum diameter2.85.114.12.33.43.0-3.82.92.91.31.8-0.2-1.21.8-1.81.11.0
Bone: maximum force2.23.88.62.62.82.7-2.22.02.91.70.41.2-1.70.8-0.81.41.8
Bone: maximum moment2.13.78.52.62.92.7-2.02.02.91.80.61.0-1.60.9-0.91.31.6
Mean time between licks in bursts0.40.51.20.30.30.7-0.60.70.80.90.10.8-1.1-0.80.81.00.5
Mean num. licks in bursts0.70.91.41.10.31.00.60.91.01.00.70.1-1.1-1.11.11.21.1
Cd content in liver1.41.55.2-2.3-1.2-1.71.5-1.5-2.1-1.1-0.20.40.9-0.50.5-0.6-0.5
Co content in liver1.11.22.5-1.3-0.5-1.30.8-0.9-1.6-0.90.5-1.51.40.6-0.6-1.4-1.4
Cu content in liver0.30.40.90.40.40.40.40.60.50.40.7-0.3-0.7-0.90.90.60.8
Fe content in liver0.20.30.60.40.3-0.30.0-0.4-0.2-0.8-0.6-0.20.70.8-0.8-0.6-0.3
K content in liver0.70.76.1-0.20.50.5-2.50.60.3-0.30.10.50.11.0-1.0-0.4-0.8
Mg content in liver0.20.20.7-0.70.40.0-0.80.4-0.00.20.80.2-0.2-0.00.0-0.1-0.2
Mn content in liver0.50.63.3-0.10.60.3-1.80.00.2-0.8-0.71.10.11.0-1.0-0.4-0.1
Na content in liver1.11.24.20.2-0.4-0.2-2.1-0.2-0.5-1.4-0.70.01.01.4-1.4-1.5-1.5
Rb content in liver1.31.73.6-1.7-0.8-1.50.3-1.7-1.6-1.9-1.11.31.30.9-0.9-1.2-1.0
Se content in liver1.01.23.9-0.9-2.0-0.8-0.4-0.9-0.7-2.0-1.51.60.4-0.50.5-0.70.6
Sr content in liver0.10.10.40.40.30.5-0.60.20.40.4-0.30.4-0.20.4-0.4-0.1-0.2
Zn content in liver0.80.93.9-0.5-0.80.2-2.0-0.00.5-1.2-1.11.7-0.20.1-0.1-0.41.2
Bone: minimum diameter6.412.026.13.95.14.7-4.44.74.33.43.5-2.0-2.31.6-1.62.30.7
Time in familiar zone, hab. session 10.80.72.20.31.10.9-0.51.30.81.11.50.1-0.8-0.40.41.20.2
Time in novel zone, hab. session 10.70.71.9-0.3-1.0-0.91.2-1.4-0.6-0.6-1.40.10.80.2-0.2-1.00.3
Total zone transitions, hab. session 10.30.42.31.51.00.8-0.20.20.90.6-0.50.1-0.30.4-0.50.30.3
Total locomotion distance, hab. session 10.91.34.82.21.71.4-0.41.01.81.2-0.2-0.4-0.80.5-0.50.60.7
Locomotion velocity, hab. session 10.91.34.12.01.71.5-0.81.21.81.2-0.0-0.3-0.90.4-0.40.80.4
Time in familiar zone, hab. session 20.70.81.50.50.90.7-0.91.10.40.41.2-1.20.21.1-1.1-0.2-1.0
Time in novel zone, hab. session 20.70.72.4-0.6-0.5-0.40.9-0.80.1-0.1-0.91.5-0.6-1.21.20.71.1
Total zone transitions, hab. session 20.10.20.80.90.00.1-0.2-0.10.40.5-0.6-0.50.20.5-0.5-0.2-0.3
Total locomotion distance, hab. session 21.01.33.31.81.01.4-0.21.11.81.60.20.0-1.2-0.50.51.31.2
Locomotion velocity, hab. session 21.01.33.31.60.81.3-0.41.11.81.50.10.4-1.3-0.60.61.31.3
Novel to familiar place preference ratio0.70.73.70.91.91.0-0.40.81.10.80.8-0.5-0.70.3-0.30.40.4
Novelty place preference0.40.42.60.61.60.6-0.30.50.70.60.6-0.7-0.30.4-0.40.10.2
Time in novel zone, NPP test0.30.42.30.51.50.5-0.20.30.50.40.4-0.7-0.00.7-0.7-0.2-0.0
Total zone transitions, NPP test0.40.62.41.5-0.10.7-0.70.11.0-0.0-1.40.9-0.50.0-0.00.30.6
Total locomotion distance, NPP test0.71.02.91.61.11.4-0.61.01.71.1-0.10.3-1.00.1-0.10.90.5
Locomotion velocity, NPP test1.21.64.32.10.71.6-0.41.32.01.1-0.30.5-1.6-1.00.91.41.3
Intraocular pressure1.21.74.72.2-0.11.30.70.81.20.60.0-0.6-1.6-2.02.01.71.2
Delta distance traveled before/after self-admin0.50.62.90.5-0.5-0.50.6-0.5-0.3-0.2-0.9-1.70.80.7-0.7-1.1-0.5
Delta ambulatory time before/after self-admin0.20.21.70.70.10.2-0.10.30.40.3-0.2-1.30.10.3-0.3-0.3-0.0
Parametrial fat weight1.12.13.7-0.11.61.4-1.01.61.71.91.50.5-1.9-1.11.11.81.7
Pavlov. Cond. lever latency1.01.23.0-1.7-0.6-0.61.4-0.3-0.4-0.20.41.7-0.8-1.71.71.20.8
Pavlov. Cond. magazine entry latency1.21.63.92.01.61.2-1.81.20.90.30.6-1.90.11.3-1.3-0.6-0.9
Pavlov. Cond. change in total contacts1.21.34.32.11.10.8-0.90.70.60.40.4-2.00.51.4-1.4-1.2-0.8
Pavlov. Cond. index score1.31.64.12.01.21.1-1.80.90.80.20.2-1.90.41.7-1.7-1.1-0.9
Pavlov. Cond. latency score1.21.53.71.90.90.9-1.70.70.60.2-0.1-1.80.61.8-1.7-1.2-1.0
Pavlov. Cond. lever contacts0.91.03.31.40.30.1-0.80.20.10.3-0.1-1.81.01.5-1.5-1.4-1.0
Pavlov. Cond. magazine entry number1.01.23.4-1.7-1.3-1.01.5-0.9-0.60.1-0.51.8-0.1-1.11.10.80.8
Pavlov. Cond. intertrial magazine entries1.82.26.32.51.82.2-0.91.81.80.80.40.4-1.8-0.80.81.70.9
Pavlov. Cond. lever-magazine prob. diff.1.21.43.92.01.11.0-1.70.80.70.10.1-1.90.41.5-1.5-1.1-0.9
Pavlov. Cond. response bias1.11.43.61.91.20.9-1.70.80.6-0.00.2-1.90.41.4-1.4-1.0-0.8
Pavlov. Cond. lever latency0.40.61.5-0.8-0.6-0.31.1-0.10.10.40.20.9-0.6-1.21.20.61.0
Pavlov. Cond. magazine entry latency2.63.04.9-2.1-2.0-2.10.1-2.1-2.2-2.1-1.50.61.80.9-0.9-1.7-2.2
Pavlov. Cond. change in total contacts0.50.72.20.30.10.1-1.30.1-0.4-0.70.1-0.40.81.3-1.3-0.8-1.5
Pavlov. Cond. index score0.91.23.5-0.3-0.4-0.7-0.8-0.8-1.0-1.2-0.6-0.71.31.5-1.5-1.2-1.9
Pavlov. Cond. latency score1.31.64.2-0.5-0.6-0.9-0.8-1.0-1.3-1.5-0.8-0.61.61.7-1.7-1.4-2.1
Pavlov. Cond. lever contacts0.30.41.01.00.60.4-0.80.20.1-0.0-0.1-1.00.30.8-0.8-0.2-0.7
Pavlov. Cond. magazine entry number3.13.86.22.22.32.4-0.32.52.52.41.9-0.8-2.1-1.11.11.92.2
Pavlov. Cond. intertrial magazine entries9.111.922.63.83.94.4-1.94.84.54.43.7-1.0-3.7-1.31.33.52.6
Pavlov. Cond. lever-magazine prob. diff.0.91.23.3-0.5-0.4-0.7-0.9-0.8-1.1-1.3-0.7-0.51.31.5-1.5-1.2-1.8
Pavlov. Cond. response bias0.30.31.50.20.20.0-0.8-0.2-0.3-0.4-0.4-0.30.50.9-0.9-0.4-1.2
Time in closed arm before self-admin0.91.12.10.0-0.6-1.01.1-1.3-0.7-0.9-1.3-1.01.31.1-1.1-1.4-0.2
Time in closed arm after self-admin1.61.63.5-1.5-0.5-1.40.1-1.2-1.1-0.9-0.6-0.41.71.9-1.9-1.5-1.7
Time in open arm before self-admin0.60.72.2-1.5-0.9-1.20.1-1.1-1.2-0.5-0.50.30.80.3-0.3-0.6-0.9
Time in open arm after self-admin0.80.83.10.3-0.30.50.20.70.30.20.50.4-1.1-1.81.81.11.3
Bone: periosteal estimation5.110.527.83.55.34.1-4.24.23.82.93.1-2.0-1.52.5-2.51.50.5
Bone: periosteal perimeter2.54.214.91.92.92.5-3.92.42.41.11.3-0.4-0.62.3-2.30.30.6
Bone: post-yield work1.21.73.71.01.91.6-1.91.71.51.21.5-0.0-0.51.3-1.30.6-0.0
Progressive ratio test 1 active lever presses2.32.47.42.71.92.2-2.31.81.91.00.1-1.4-1.10.5-0.50.5-0.5
Progressive ratio test 1 breakpoint2.93.010.53.22.02.5-2.42.02.21.20.2-1.6-1.40.3-0.30.7-0.4
Progressive ratio test 1 inactive lever presses2.72.910.33.22.22.4-2.51.72.30.8-0.0-1.4-0.91.0-1.00.2-0.1
Progressive ratio test 2 active lever presses2.42.66.12.32.02.5-2.22.11.91.01.2-1.0-1.7-0.20.21.20.2
Progressive ratio test 2 breakpoint2.42.76.02.22.22.5-2.32.21.81.21.4-1.1-1.6-0.10.11.2-0.1
Progressive ratio test 2 inactive lever presses3.43.98.92.92.73.0-1.82.52.71.31.4-0.7-2.1-0.40.41.71.1
Incentive Sensitization - Responses1.21.33.70.91.21.7-1.91.61.10.81.4-0.2-1.2-0.20.21.10.1
Incentive Sensitization - Breakpoint1.11.14.00.71.11.5-2.01.51.00.71.4-0.2-1.1-0.10.10.90.1
Sum of active levers in priming session hrs 5-60.70.61.5-0.1-0.7-0.90.4-1.0-1.2-0.9-1.1-0.51.00.2-0.2-1.2-0.0
Progressive ratio0.30.32.0-1.4-0.6-0.0-1.10.3-0.2-0.50.30.5-0.3-0.30.30.4-0.1
Food seeking constrained by brief footshock1.72.17.00.61.31.0-1.31.70.61.82.3-1.70.11.3-1.30.2-2.6
Seeking ratio, punishment vs. effort0.81.02.61.61.30.60.10.70.41.41.0-1.40.31.0-1.0-0.2-1.3
Retroperitoneal fat weight1.44.514.02.22.92.4-0.72.62.83.71.9-1.2-2.0-0.20.22.21.0
Reaction time number correct0.50.72.7-0.8-0.7-0.5-0.5-0.7-0.3-1.1-1.71.3-0.1-0.60.50.20.8
Reaction time mean minus median0.20.31.3-0.8-0.4-0.61.1-0.2-0.40.20.4-0.3-0.1-0.90.90.2-0.1
Reaction time mean minus median AUC0.20.30.7-0.9-0.3-0.70.7-0.7-0.4-0.5-0.80.60.1-0.50.5-0.20.2
Reaction time num false alarms1.41.96.12.11.51.7-2.51.71.60.20.3-0.8-0.21.5-1.5-0.00.3
Reaction time num false alarms AUC1.52.16.92.01.81.9-2.61.91.70.50.6-0.8-0.41.4-1.40.20.3
Reaction time trials correct on left0.50.72.7-0.8-0.7-0.5-0.5-0.7-0.3-1.1-1.71.3-0.1-0.60.50.20.8
Reaction time trials on left0.40.62.5-0.8-0.6-0.4-0.5-0.6-0.2-1.1-1.61.3-0.2-0.60.60.30.9
Reaction time mean0.50.81.9-1.3-0.3-1.10.8-1.0-1.4-1.1-0.2-0.10.80.2-0.2-0.7-1.4
Reaction time mean AUC0.91.22.8-1.4-0.5-1.41.1-1.3-1.7-1.1-0.2-0.41.10.4-0.4-1.0-1.6
Median of all reaction times0.70.92.8-1.1-0.1-1.00.7-1.1-1.4-1.2-0.3-0.20.90.6-0.6-0.8-1.7
Reaction time omissions0.60.82.1-0.20.80.60.40.91.00.70.80.9-1.2-1.01.01.40.7
Reaction time false alarm rate1.41.93.51.91.61.5-1.91.71.30.81.3-1.50.01.7-1.7-0.2-0.3
Reaction time premature initiation rate0.81.14.42.11.21.40.01.01.41.10.40.0-0.8-0.20.20.61.2
Reaction time premature initiations0.60.92.71.50.71.1-0.40.71.20.5-0.50.8-0.9-0.60.60.81.7
Std. dev. reaction times0.30.41.8-1.3-0.0-0.71.0-0.2-0.6-0.00.8-0.10.1-0.40.40.1-0.6
Reaction time trials completed0.40.62.5-0.8-0.6-0.4-0.5-0.6-0.2-1.1-1.61.3-0.2-0.60.60.30.9
Reaction time trials AUC0.40.62.3-0.9-0.6-0.4-0.5-0.6-0.3-1.0-1.51.2-0.2-0.60.60.40.8
Run reversals in cocaine runway, females1.11.15.8-0.5-0.8-0.52.4-0.5-0.31.10.40.4-0.5-1.61.60.70.9
Run reversals in cocaine runway, males0.20.21.0-0.30.1-0.0-0.0-0.1-0.1-0.6-0.11.0-0.2-0.30.30.10.6
Latency to leave start box in cocaine runway0.50.61.1-0.5-0.8-1.00.5-1.0-0.7-0.7-0.9-0.11.00.6-0.6-0.9-0.6
Latency to leave start box in cocaine runway, F1.21.43.0-0.3-1.2-1.20.4-1.3-1.0-1.7-1.60.21.51.1-1.1-1.5-0.8
Latency to leave start box in cocaine runway, M0.20.20.7-0.80.3-0.40.6-0.2-0.40.80.7-0.60.1-0.10.10.1-0.2
Std. dev. time between licks in bursts0.30.30.90.4-0.30.20.50.20.40.70.20.3-0.6-1.01.00.60.7
Total sessions with >9 infusions0.70.84.52.10.21.0-0.7-0.00.8-0.5-1.7-0.2-0.7-0.50.50.00.3
Short access day 1 total inactive lever presses0.60.72.51.61.11.2-0.90.81.20.0-0.0-0.8-0.40.7-0.70.1-0.3
Short access day 10 total inactive lever presses1.11.24.31.21.51.20.01.21.61.01.2-0.3-0.7-0.00.00.72.1
Short access day 1 total infusions1.31.38.52.91.11.5-1.00.61.4-0.3-1.3-1.1-0.70.0-0.0-0.1-0.2
Short access day 10 total infusions4.44.913.53.73.03.1-1.52.83.32.31.2-1.1-2.1-0.10.11.51.0
Short access total infusions2.12.410.83.32.12.1-1.31.42.00.6-0.1-2.0-0.70.8-0.8-0.00.1
Short access day 1 locomotion3.53.815.53.92.12.9-1.12.02.61.60.0-0.4-2.2-0.90.91.41.2
Short access day 10 total locomotion6.37.017.84.23.53.6-1.73.63.43.02.4-2.2-2.2-0.10.11.80.4
Short access total locomotion3.94.017.34.22.42.8-1.12.32.81.90.6-1.6-1.7-0.20.21.00.6
One hour access (0.3 mA shock)0.50.61.30.91.10.8-1.20.60.50.40.4-1.1-0.00.8-0.8-0.2-0.9
Compulsive drug intake1.41.42.7-1.6-0.9-1.4-0.1-1.5-1.2-1.4-1.20.51.51.2-1.2-1.3-0.4
One hour access (shock baseline)1.01.23.01.71.31.5-0.71.51.11.21.0-1.1-1.1-0.40.40.8-0.0
Social response proportion0.10.10.4-0.2-0.1-0.40.4-0.6-0.2-0.4-0.40.50.3-0.00.00.00.5
Social responses0.50.61.60.90.8-0.0-0.2-0.4-0.00.1-0.6-1.20.81.3-1.3-0.8-0.4
Social time0.20.31.0-1.0-0.9-0.70.1-0.5-0.9-0.80.00.10.6-0.10.1-0.4-0.5
Soleus weight0.10.41.41.2-0.20.4-0.9-0.10.3-0.8-0.90.20.20.4-0.5-0.60.6
Bone: stiffness1.11.85.81.41.91.7-2.41.41.70.80.10.6-0.71.3-1.30.70.5
Tibialis anterior weight0.82.76.31.80.71.11.51.11.62.51.30.1-1.7-2.12.11.42.3
Time to tail flick, vehicle, before self-admin0.90.93.8-2.0-0.5-0.6-1.0-0.5-1.1-1.10.01.80.50.6-0.6-0.2-0.8
Time to tail flick, vehicle, after self-admin1.21.33.20.20.21.2-1.51.20.90.10.81.8-1.5-1.11.21.41.1
Time to tail flick, test, before self-admin0.60.62.8-1.7-0.1-1.01.1-0.6-1.2-0.10.8-0.10.4-0.20.3-0.1-0.4
Time to tail flick, test, after self-admin0.20.21.40.00.3-0.10.10.00.1-0.3-0.50.3-0.2-0.40.40.11.2
Delta time to tail flick, vehicle, before/after SA2.22.23.81.51.41.8-0.51.91.91.61.7-0.4-1.8-1.11.11.71.2
Delta time to tail flick, test, before/after SA0.20.20.70.30.50.4-0.90.20.3-0.5-0.50.4-0.20.2-0.20.00.8
Tibia length0.30.73.30.6-0.20.4-1.5-0.50.4-1.1-1.81.3-0.10.6-0.6-0.10.4
Ambulatory time before self-admin1.11.12.5-1.4-1.2-1.0-1.0-0.9-1.0-1.6-1.00.91.10.9-0.9-1.1-0.1
Ambulatory time after self-admin0.70.71.5-0.2-0.6-0.5-1.0-0.1-0.4-1.1-0.8-0.91.01.2-1.2-1.2-0.4
Bone: tissue strength0.80.82.9-0.6-1.1-0.7-0.3-1.1-0.6-1.4-1.71.20.50.2-0.2-0.3-0.2
Total heroin consumption0.60.71.80.20.2-0.1-1.2-0.0-0.2-1.2-0.8-0.20.91.3-1.3-1.1-0.4
Bone: trabecular number0.91.45.90.91.11.7-2.41.51.60.50.51.3-1.00.5-0.50.80.5
Bone: trabecular spacing0.50.61.6-0.6-0.7-1.11.0-0.7-1.1-0.4-0.1-1.30.80.0-0.0-0.8-1.1
Bone: trabecular thickness1.72.14.21.41.31.9-1.31.62.11.31.01.5-1.7-0.60.61.41.6
Bone: trabecular tissue density0.91.35.60.1-0.60.30.0-0.50.8-0.2-1.62.4-1.0-1.11.11.12.1
Water consumed over 24 hours0.40.51.31.00.50.60.20.41.11.1-0.20.1-0.6-0.20.20.61.1
Number of responses in last shaping day0.50.52.31.50.90.7-0.50.50.70.0-0.4-1.4-0.20.2-0.2-0.20.3