Hub : Genes

Kmt5c

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA intron excision ratio chr1_78132709_78133249 0.12 0.13 1.1e-03 0 -0 0.01 -0 1.3e-01 7.9e-01 5.3e-02 6.5e-01
2 NAcc intron excision ratio chr1_78132709_78133249 0.06 0.04 2.0e-07 0.05 0.05 0.05 0.05 4.1e-08 1.1e-07 1.3e-07 1.5e-07
3 Brain intron excision ratio chr1_78133358_78133698 0.02 0.02 9.3e-03 0.01 0.01 0 0.01 3.8e-02 5.2e-02 3.3e-01 8.5e-02
4 Brain intron excision ratio chr1_78133486_78133698 0.02 0.02 8.8e-03 0.01 0.01 0 0.01 2.3e-02 3.9e-02 2.3e-01 6.1e-02
5 LHb gene expression Kmt5c 0.17 0.11 2.2e-03 0.06 0.07 -0.01 0.06 1.8e-02 9.3e-03 5.5e-01 1.4e-02
6 BLA gene expression Kmt5c 0.06 0.04 6.5e-03 0.03 0.03 0.01 0.03 1.6e-02 1.2e-02 1.0e-01 1.3e-02
7 IC intron excision ratio chr1_78132709_78133249 0.14 0.09 5.0e-04 0.02 0.04 0.04 0.03 3.9e-02 9.1e-03 6.3e-03 1.5e-02
8 Brain intron excision ratio chr1_78132709_78133249 0.05 0.04 2.3e-05 0.04 0.04 0.04 0.04 8.7e-05 1.2e-04 1.9e-04 8.0e-05
9 PL intron excision ratio chr1_78133007_78133249 0.02 0.01 9.6e-03 0.01 0.01 0 0 4.8e-02 3.0e-02 7.6e-02 1.0e-01
10 PL intron excision ratio chr1_78132709_78133249 0.02 0.02 5.4e-03 0.01 0.02 0.01 0.01 1.2e-02 6.4e-03 1.3e-02 1.8e-02
11 Brain gene expression Kmt5c 0.11 0.06 7.5e-14 0.1 0.12 0.12 0.13 7.0e-10 4.7e-11 4.9e-11 3.4e-12
12 PL gene expression Kmt5c 0.03 0.02 1.6e-03 0.01 0.01 -0 0 9.2e-03 6.4e-02 5.2e-01 1.3e-01
13 RMTg gene expression Kmt5c 0.16 0.1 3.0e-04 0.03 0.13 0.08 0.1 5.0e-02 3.2e-04 3.8e-03 1.5e-03
14 NAcc gene expression Kmt5c 0.04 0.03 2.4e-04 0.01 0.02 0.02 0.02 6.5e-03 2.8e-04 5.1e-04 1.0e-03
15 IC intron excision ratio chr1_78132709_78132844 0.14 0.09 2.1e-03 0.05 0.01 0.01 0.02 4.6e-03 7.3e-02 8.9e-02 3.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.10.10.30.10.3-0.30.3-0.3-0.30.3-0.40.4-0.4-0.40.5-0.4-0.1-0.2
Area under the delay curve0.30.40.8-0.7-0.70.7-0.70.60.7-0.90.6-0.60.60.7-0.70.60.50.5
BMI with tail0.51.92.6-1.6-1.41.4-1.41.31.3-1.41.5-1.41.41.5-1.51.40.80.3
BMI without tail0.00.20.60.60.4-0.30.3-0.5-0.50.5-0.50.2-0.2-0.50.6-0.2-0.8-0.7
Body weight1.14.96.52.02.5-2.42.4-2.5-2.42.4-2.22.1-2.0-2.02.1-2.0-2.6-1.1
Weight adjusted by age0.20.61.20.40.7-0.90.9-0.8-0.80.7-0.81.1-1.1-0.70.8-1.1-0.10.4
Bone surface2.85.57.21.92.5-2.72.7-2.5-2.52.6-2.42.4-2.3-2.42.3-2.3-2.1-0.9
Bone volume2.14.25.41.62.2-2.32.3-2.2-2.22.2-2.12.1-2.1-2.12.2-2.0-1.8-0.9
Breakpoint value in progressive ratio session0.20.40.7-0.7-0.70.7-0.70.70.7-0.30.8-0.70.70.8-0.80.70.60.4
Number of licking bursts0.00.10.10.4-0.30.3-0.30.30.3-0.20.3-0.30.30.3-0.10.30.2-0.2
Context. condit. distance diff. score0.20.32.5-0.2-0.30.3-0.30.40.5-0.10.5-0.20.10.5-0.40.20.81.6
Locomotion velocity, session 10.70.85.6-0.5-0.40.5-0.50.50.6-0.50.20.3-0.50.10.1-0.52.12.4
Locomotion distance, session 11.92.44.01.41.4-1.51.5-1.4-1.31.6-1.61.9-2.0-1.71.6-2.00.11.2
Locomotion velocity, session 20.20.31.7-0.1-0.60.4-0.40.60.5-0.50.4-0.10.00.3-0.2-0.01.30.9
Locomotion distance, session 21.52.13.11.31.5-1.41.4-1.4-1.41.2-1.71.7-1.8-1.81.8-1.8-0.40.3
Locomotion velocity, session 30.00.00.2-0.1-0.30.1-0.10.30.3-0.20.2-0.10.10.2-0.20.10.50.2
Locomotion distance, session 30.20.20.40.40.2-0.50.5-0.3-0.20.5-0.40.5-0.6-0.40.3-0.60.40.6
Stereotopy head waving bouts, day 30.10.10.3-0.2-0.30.6-0.60.30.30.00.5-0.40.40.5-0.40.40.10.1
Stereotopy head waving duration, day 30.10.10.3-0.3-0.30.5-0.50.30.3-0.10.5-0.40.40.5-0.30.4-0.00.0
Locomotion velocity, session 70.10.10.40.10.1-0.00.0-0.0-0.00.3-0.00.3-0.3-0.10.1-0.30.40.6
Locomotion distance, session 70.10.10.8-0.10.00.2-0.20.10.1-0.10.20.2-0.30.2-0.1-0.30.80.9
Stereotopy head waving bouts, day 70.20.20.80.60.4-0.30.3-0.5-0.50.9-0.40.3-0.3-0.40.5-0.2-0.7-0.5
Stereotopy head waving duration, day 70.20.20.60.50.4-0.50.5-0.5-0.50.8-0.40.3-0.3-0.30.5-0.3-0.7-0.5
Locomotion velocity, session 80.20.21.6-0.2-0.20.3-0.30.30.30.10.10.1-0.20.10.1-0.21.11.3
Locomotion distance, session 80.20.32.50.30.4-0.20.2-0.2-0.20.4-0.30.6-0.7-0.40.4-0.70.61.6
Degree of sensitization distance0.00.00.1-0.00.10.1-0.1-0.0-0.00.10.10.1-0.10.10.1-0.10.10.3
Degree of sensitization stereotypy0.10.10.30.30.1-0.20.2-0.2-0.20.5-0.20.0-0.0-0.20.20.0-0.5-0.4
Conditioned locomotion0.10.11.1-0.00.1-0.20.2-0.00.00.30.10.3-0.30.1-0.1-0.30.51.0
Cocaine response after cond. corrected1.21.83.5-1.9-1.21.0-1.01.11.1-1.61.2-1.61.71.2-1.31.7-0.2-1.3
Cocaine response after cond. not corrected0.20.32.3-0.30.3-0.50.5-0.4-0.5-0.0-0.40.00.1-0.50.40.1-1.1-1.5
Cocaine response before conditioning6.98.410.23.03.0-2.92.9-3.0-2.93.1-3.23.1-3.2-3.23.2-3.1-1.8-0.0
Saline control response0.20.21.20.3-0.1-0.40.40.10.20.30.20.4-0.40.30.1-0.51.01.1
Bone: connectivity density0.00.10.3-0.6-0.20.0-0.00.20.2-0.30.2-0.20.20.2-0.20.20.1-0.1
Bone: cortical apparent density0.10.10.4-0.6-0.0-0.30.3-0.0-0.0-0.5-0.10.4-0.4-0.10.2-0.40.50.4
Bone: cortical area0.81.32.11.31.3-1.31.3-1.2-1.21.5-1.11.2-1.2-1.00.9-1.1-1.00.0
Bone: cortical porosity0.50.50.8-0.7-0.70.8-0.80.70.7-0.20.7-0.90.90.7-0.70.90.2-0.7
Bone: cortical porosity0.20.21.0-0.2-0.20.3-0.30.30.20.40.2-0.50.60.2-0.20.6-0.4-1.0
Bone: cortical thickness0.40.61.0-0.6-0.90.8-0.80.80.8-0.60.9-0.60.60.9-1.00.61.00.5
Bone: cortical thickness0.10.10.20.40.2-0.30.3-0.2-0.2-0.1-0.20.4-0.4-0.30.3-0.50.20.1
Bone: cortical tissue density0.10.10.5-0.7-0.0-0.30.30.0-0.0-0.6-0.10.3-0.3-0.10.1-0.40.50.4
Condit. Reinf. active minus inactive responses0.20.20.3-0.5-0.50.3-0.30.50.5-0.20.5-0.50.50.5-0.60.50.20.1
Condit. Reinf. active-inactive response ratio1.51.72.7-1.3-1.41.1-1.11.31.3-1.21.5-1.41.41.5-1.61.40.70.6
Condit. Reinf. active responses0.10.10.50.20.3-0.40.4-0.3-0.30.7-0.40.3-0.3-0.50.4-0.3-0.3-0.2
Condit. Reinf. inactive responses2.83.65.11.82.0-1.71.7-1.9-1.92.3-2.22.1-2.1-2.22.3-2.1-1.1-0.4
Incentive salience index mean0.10.10.20.10.2-0.40.4-0.3-0.30.4-0.30.3-0.3-0.30.1-0.3-0.20.1
Condit. Reinf. lever presses0.60.91.20.61.0-1.01.0-1.0-1.00.7-1.01.1-1.1-1.00.9-1.1-0.7-0.2
Condit. Reinf. active minus inactive responses3.25.09.23.02.4-2.22.2-2.3-2.32.5-2.22.3-2.3-2.12.2-2.3-1.6-0.6
Condit. Reinf. active-inactive response ratio4.26.78.93.02.8-2.62.6-2.8-2.82.7-2.72.5-2.5-2.62.6-2.5-2.4-1.6
Condit. Reinf. active responses2.94.29.53.12.1-1.91.9-2.0-1.92.5-1.92.2-2.2-1.92.0-2.2-1.00.2
Condit. Reinf. inactive responses0.10.21.70.80.10.1-0.10.00.10.60.00.2-0.20.00.1-0.20.61.3
Condit. Reinf. lever presses0.81.12.91.71.1-0.70.7-1.1-1.01.5-1.00.7-0.6-0.91.0-0.6-1.5-1.0
Condit. Reinf. lever reinforcers received3.95.411.83.42.4-2.22.2-2.3-2.22.8-2.22.5-2.5-2.22.3-2.5-1.20.2
Conditioned reinforcement - actives0.10.52.5-1.60.5-0.70.7-0.6-0.6-0.1-0.60.4-0.4-0.60.6-0.4-0.9-0.2
Conditioned reinforcement - inactives1.02.73.70.61.8-1.61.6-1.9-1.91.2-1.91.9-1.9-1.91.9-1.9-1.2-0.2
Conditioned locomotion0.10.21.0-1.00.4-0.50.5-0.4-0.40.1-0.40.3-0.2-0.40.4-0.2-0.7-0.1
Patch foraging indifference point 0 sec0.30.92.9-1.7-0.80.6-0.60.90.9-0.80.8-0.50.50.8-0.80.51.41.6
Patch foraging indifference point AUC0.30.71.2-0.6-1.01.1-1.10.90.9-0.90.8-0.90.90.8-0.80.90.6-0.1
Delay disc. indifference point, 0s delay0.20.21.1-0.8-0.30.3-0.30.20.2-0.30.30.2-0.30.3-0.3-0.31.01.0
Delay disc. indifference point, 16s delay0.40.61.40.1-0.70.7-0.70.70.7-0.60.6-1.11.20.6-0.71.2-0.3-0.7
Delay disc. indifference point, 2s delay0.70.82.3-1.1-0.90.9-0.90.80.8-1.50.9-0.60.60.9-0.70.60.90.4
Delay disc. indifference point, 24s delay0.30.51.0-0.4-0.80.8-0.80.80.8-0.70.7-1.01.00.7-0.71.00.1-0.1
Delay disc. indifference point, 4s delay0.10.10.20.30.2-0.20.2-0.3-0.3-0.1-0.30.2-0.2-0.30.2-0.2-0.4-0.3
Delay disc. indifference point, 8s delay0.10.10.3-0.5-0.40.4-0.40.30.4-0.50.3-0.30.20.3-0.40.20.40.5
Indifference point function ln k2.37.09.22.82.8-2.82.8-2.7-2.72.9-2.73.0-3.0-2.62.7-3.0-1.4-0.1
Indifference point function log k2.37.09.22.82.8-2.82.8-2.7-2.72.9-2.73.0-3.0-2.62.7-3.0-1.4-0.1
Patch foraging total patch changes 0 sec0.30.82.7-1.5-0.80.6-0.60.80.9-0.80.8-0.50.40.8-0.80.41.31.6
Patch foraging total patch changes 12 sec0.30.42.1-1.4-0.60.5-0.50.50.6-0.50.4-0.60.60.4-0.40.60.30.7
Patch foraging total patch changes 18 sec0.40.91.5-1.2-0.90.7-0.71.01.0-1.01.0-0.90.81.0-1.00.80.91.0
Patch foraging total patch changes 24 sec0.00.10.60.50.1-0.20.2-0.2-0.20.1-0.3-0.10.2-0.30.30.2-0.7-0.6
Patch foraging total patch changes 6 sec0.81.42.1-1.4-1.21.2-1.21.21.3-1.11.1-1.21.11.1-1.01.21.01.1
Patch foraging time to switch 0 sec0.83.16.5-1.7-1.61.5-1.51.51.4-1.81.6-2.42.51.6-1.62.6-0.8-1.6
Patch foraging water rate 0 sec0.20.81.61.00.7-0.70.7-0.7-0.60.9-0.81.2-1.2-0.80.7-1.30.51.2
Patch foraging water rate 12 sec0.83.06.12.51.7-1.71.7-1.5-1.41.8-1.62.1-2.2-1.61.7-2.20.11.2
Patch foraging water rate 18 sec0.51.12.31.50.9-0.90.9-0.9-0.91.2-1.01.4-1.4-1.00.9-1.50.20.7
Patch foraging water rate 24 sec0.71.01.71.21.0-1.11.1-0.9-0.91.0-1.01.2-1.3-1.00.9-1.3-0.10.4
Patch foraging water rate 6 sec6.08.816.04.03.1-3.13.1-3.0-3.03.0-3.02.9-2.9-3.03.1-2.9-2.3-1.3
Seeking ratio, delayed vs. immediate footshock0.30.42.9-0.7-0.10.1-0.10.10.10.30.10.5-0.50.1-0.2-0.51.11.7
Distance traveled before self-admin0.81.74.20.51.1-1.11.1-1.1-1.11.3-1.01.9-2.0-1.01.0-2.00.71.4
Distance traveled after self-admin0.50.93.3-0.9-0.80.8-0.80.80.90.00.9-0.20.10.9-0.90.11.81.8
Extensor digitorum longus weight0.20.92.01.01.1-1.11.1-1.1-1.11.1-0.80.8-0.8-0.70.7-0.7-1.4-0.8
Bone: elastic displacement0.50.61.4-0.7-0.71.2-1.20.80.8-0.10.8-0.60.50.8-0.70.51.10.8
Bone: elastic work0.30.40.80.80.8-0.40.4-0.7-0.60.7-0.60.9-0.9-0.50.7-0.9-0.10.6
Bone: endosteal estimation2.76.68.32.62.9-2.82.8-2.9-2.82.5-2.62.5-2.5-2.52.5-2.4-2.6-0.7
Bone: endosteal perimeter1.64.05.12.22.2-2.22.2-2.2-2.12.2-2.02.0-2.0-1.91.8-2.0-1.80.0
Epididymis fat weight0.10.31.90.60.2-0.10.1-0.3-0.30.1-0.1-0.30.4-0.0-0.10.5-1.4-1.2
Delta time in closed arm before/after self-admin0.10.10.5-0.7-0.30.3-0.30.30.3-0.60.1-0.20.2-0.00.00.20.30.0
Delta time in open arm before/after self-admin1.21.43.10.81.2-1.31.3-1.2-1.21.8-1.11.4-1.4-1.11.1-1.4-0.50.1
Diff in mean of infusions in LGA sessions0.10.10.7-0.3-0.1-0.10.10.00.0-0.30.00.3-0.40.0-0.0-0.40.70.8
Delay discount exponential model param0.20.30.60.50.6-0.60.6-0.5-0.50.7-0.50.5-0.5-0.50.6-0.5-0.4-0.4
Extinction: sum of active levers before priming0.10.10.40.2-0.30.5-0.50.30.40.10.4-0.20.10.4-0.40.10.70.5
Active lever presses in extinction session 60.20.21.20.10.0-0.10.10.0-0.00.00.1-0.50.60.1-0.10.6-1.0-1.1
Bone: final force2.13.54.32.02.1-2.02.0-2.0-2.01.5-1.92.0-1.9-1.91.9-1.9-1.6-0.6
Bone: final moment2.74.35.32.32.3-2.32.3-2.3-2.21.7-2.12.2-2.2-2.12.1-2.2-1.6-0.5
Food consumed during 24 hour testing period1.12.33.41.31.6-1.61.6-1.6-1.61.5-1.61.6-1.6-1.61.8-1.6-1.2-0.1
Glucose1.82.83.9-1.1-1.71.7-1.71.81.8-1.71.8-1.51.41.7-1.91.42.01.5
Heart weight1.52.43.41.11.6-1.61.6-1.6-1.71.6-1.71.3-1.3-1.71.7-1.2-1.8-1.2
Delay discount hyperbolic model param0.30.40.90.70.7-0.70.7-0.6-0.60.9-0.60.6-0.6-0.60.7-0.5-0.5-0.5
Intermittent access intake day 1-15 change0.20.91.30.71.1-1.01.0-1.1-1.10.9-0.91.0-1.0-0.90.9-1.0-0.9-0.6
Intermittent access intake escalation0.31.62.11.41.5-1.31.3-1.4-1.41.1-1.21.2-1.2-1.11.1-1.2-1.3-0.9
Intermittent access intake escalation 20.10.10.30.40.3-0.30.3-0.3-0.30.3-0.10.5-0.5-0.10.1-0.60.20.1
Intermitt. access day 1 inactive lever presses0.22.22.81.61.6-1.41.4-1.6-1.61.4-1.61.3-1.3-1.61.6-1.3-1.7-1.1
Intermitt. access day 15 inactive lever presses0.73.95.31.32.0-1.91.9-2.1-2.12.1-2.31.7-1.7-2.32.3-1.6-2.3-1.7
Intermitt. access escalation Index0.30.83.8-2.0-0.60.8-0.80.70.8-0.90.9-0.70.71.0-1.00.70.60.9
Intermittent access day 1 total infusions0.20.61.0-0.50.9-0.90.9-0.9-0.90.3-0.80.7-0.7-0.80.8-0.6-1.0-0.1
Intermittent access day 15 total infusions0.51.22.30.21.4-1.31.3-1.3-1.30.6-1.11.0-1.0-1.01.0-1.0-1.5-0.7
Intermittent access terminal intake (last 3 days)0.61.01.60.21.3-1.21.2-1.2-1.20.5-1.01.0-1.0-0.90.9-1.0-1.3-0.6
Intermittent access total infusions1.31.62.3-0.21.5-1.51.5-1.5-1.50.6-1.31.3-1.2-1.31.3-1.2-1.5-0.5
Intermittent access day 1 locomotion0.71.31.8-0.21.3-1.31.3-1.3-1.30.6-1.21.2-1.2-1.21.2-1.2-1.2-0.1
Intermittent access day 15 total locomotion0.41.42.51.11.4-1.31.3-1.3-1.30.7-1.11.5-1.6-1.01.0-1.6-0.50.3
Intermittent access total locomotion2.63.24.30.82.1-2.12.1-2.1-2.01.2-1.82.0-2.0-1.71.7-2.0-1.6-0.2
Intermittent access standard deviation0.10.40.8-0.7-0.40.4-0.40.50.5-0.80.8-0.40.40.9-0.90.40.50.4
Left kidney weight3.024.329.25.05.3-5.35.3-5.3-5.25.4-5.15.0-4.9-5.04.9-4.9-4.4-1.5
Right kidney weight3.524.430.64.55.4-5.25.2-5.4-5.35.5-5.34.8-4.8-5.35.1-4.7-4.8-1.8
Cocaine induced anxiety0.51.22.60.91.1-1.21.2-1.1-1.11.6-1.11.1-1.1-1.11.1-1.1-0.9-0.4
Post-drug Anxiety0.80.92.51.60.9-0.80.8-0.8-0.91.4-0.80.6-0.5-0.80.8-0.5-1.1-1.1
Baseline Anxiety0.40.61.1-0.0-0.70.9-0.90.80.8-1.00.9-0.90.90.9-0.90.90.4-0.1
Tail length2.413.115.33.83.9-3.93.9-3.8-3.83.9-3.83.6-3.5-3.73.8-3.5-3.2-1.6
Length with tail3.113.816.83.94.1-4.14.1-4.0-4.03.9-3.73.5-3.4-3.63.7-3.4-3.8-1.9
Length without tail1.05.09.81.82.6-2.62.6-2.5-2.52.3-2.21.8-1.7-2.01.9-1.7-3.1-1.8
Times rat made contact with spout0.10.10.6-0.8-0.20.3-0.30.20.2-0.20.2-0.30.40.2-0.10.4-0.2-0.2
Lifetime Intake0.91.11.7-0.51.2-1.21.2-1.2-1.20.4-1.11.0-1.0-1.11.1-1.0-1.3-0.5
Liver weight, left1.01.82.11.21.4-1.41.4-1.4-1.41.5-1.41.3-1.3-1.41.4-1.2-1.3-0.4
Liver weight, right0.00.10.6-0.50.10.0-0.0-0.1-0.00.2-0.20.1-0.1-0.10.1-0.0-0.10.8
Locomotor activity0.10.10.4-0.6-0.10.3-0.30.30.3-0.30.2-0.40.40.3-0.10.5-0.10.0
Locomotor testing distance0.10.10.7-0.10.3-0.30.3-0.3-0.30.2-0.3-0.10.1-0.20.30.2-0.9-0.7
Locomotor testing rearing0.20.81.20.21.0-1.11.1-1.0-0.91.0-1.00.8-0.8-1.00.9-0.7-1.10.0
Locomotion in novel chamber1.52.04.8-2.2-1.41.1-1.11.41.4-1.51.6-1.21.21.6-1.61.21.31.1
Locomotion in novel chamber post-restriction0.31.04.6-2.1-0.90.7-0.70.90.9-1.40.9-0.90.90.9-1.01.00.50.5
Fecal boli incidents, locomotor time 10.10.30.50.70.6-0.60.6-0.6-0.60.4-0.60.7-0.7-0.60.5-0.7-0.30.2
Change in fecal boli incidents, locomotor task3.03.14.4-2.0-1.81.8-1.81.91.8-2.11.9-1.71.71.9-1.81.61.70.8
Time >=10cm from walls, locomotor time 10.00.00.1-0.2-0.00.0-0.00.10.1-0.20.1-0.20.20.1-0.10.2-0.1-0.2
Bouts of movement, locomotor time 10.40.52.3-0.20.5-0.50.5-0.3-0.30.5-0.30.9-1.0-0.30.1-1.01.01.5
Total resting periods, locomotor time 10.20.21.6-0.30.0-0.00.00.10.2-0.10.20.3-0.40.1-0.4-0.41.01.3
Rest time, locomotor task time 11.01.62.31.51.5-1.51.5-1.3-1.31.0-1.31.3-1.2-1.41.2-1.2-1.1-0.4
Distance moved, locomotor task time 10.61.72.3-1.2-1.51.5-1.51.41.4-0.91.4-1.31.31.4-1.31.31.20.5
Vertical activity count, locomotor time 10.64.16.2-2.2-2.32.3-2.32.12.1-1.72.1-1.61.52.2-2.11.52.51.7
Time >=10cm from walls, locomotor time 20.30.81.1-0.8-0.80.8-0.80.90.9-1.00.9-1.01.10.9-0.91.10.4-0.3
Bouts of movement, locomotor time 20.00.00.00.10.2-0.20.2-0.1-0.10.1-0.20.1-0.1-0.20.0-0.1-0.10.2
Total resting periods, locomotor time 20.00.00.10.00.2-0.20.2-0.1-0.1-0.0-0.10.2-0.2-0.20.1-0.20.00.3
Rest time, locomotor task time 20.00.10.5-0.40.0-0.00.0-0.00.0-0.1-0.00.3-0.3-0.0-0.0-0.30.50.7
Distance moved, locomotor task time 20.10.20.2-0.2-0.50.5-0.50.50.5-0.10.5-0.40.40.5-0.40.40.40.0
Vertical activity count, locomotor time 20.10.30.5-0.4-0.60.6-0.60.50.6-0.50.5-0.40.40.6-0.70.30.70.7
Light reinforcement 10.10.52.7-1.7-0.60.1-0.10.50.5-0.40.40.1-0.20.4-0.3-0.21.41.3
Light reinforcement 21.02.33.3-1.6-1.71.4-1.41.61.6-1.71.8-1.31.21.8-1.81.21.70.5
Bone: marrow area2.76.68.42.62.9-2.82.8-2.9-2.82.6-2.62.5-2.5-2.52.5-2.4-2.7-0.8
Bone: maximum diameter1.02.12.91.61.6-1.61.6-1.6-1.61.7-1.41.3-1.3-1.31.1-1.2-1.7-0.3
Bone: maximum force2.85.67.02.52.6-2.62.6-2.6-2.62.2-2.42.4-2.4-2.32.4-2.3-2.2-0.7
Bone: maximum moment3.36.37.82.72.8-2.82.8-2.8-2.72.3-2.52.6-2.6-2.42.5-2.6-2.2-0.6
Mean time between licks in bursts0.20.92.1-0.7-1.01.1-1.11.01.0-1.01.0-0.70.61.0-0.70.61.40.9
Mean num. licks in bursts0.10.20.5-0.70.4-0.40.4-0.5-0.40.2-0.40.3-0.3-0.40.3-0.2-0.70.0
Cd content in liver2.12.33.11.31.6-1.81.8-1.6-1.61.6-1.61.7-1.7-1.61.6-1.7-1.0-0.2
Co content in liver0.60.71.60.80.7-0.90.9-0.7-0.80.3-0.61.2-1.2-0.61.1-1.30.2-0.1
Cu content in liver1.11.32.00.91.1-1.41.4-1.1-1.20.9-1.01.0-1.0-1.01.2-1.0-1.1-1.3
Fe content in liver0.30.40.70.80.6-0.80.8-0.6-0.60.6-0.50.6-0.6-0.50.5-0.6-0.6-0.7
K content in liver0.00.00.10.3-0.1-0.10.10.00.00.2-0.0-0.00.1-0.10.30.0-0.1-0.4
Mg content in liver0.10.10.8-0.2-0.2-0.00.00.20.2-0.10.2-0.40.50.2-0.10.5-0.4-0.9
Mn content in liver0.10.10.4-0.0-0.0-0.10.10.0-0.00.50.1-0.20.30.1-0.10.3-0.5-0.6
Na content in liver2.73.03.9-1.9-2.01.7-1.72.01.9-1.51.9-1.81.81.9-1.51.81.50.4
Rb content in liver3.03.54.61.71.9-1.91.9-1.9-1.92.1-2.01.6-1.5-2.02.0-1.5-2.0-1.7
Se content in liver1.92.33.9-1.6-1.51.4-1.41.51.5-1.11.7-1.81.81.8-2.01.80.60.5
Sr content in liver7.26.311.2-3.3-2.62.5-2.52.62.5-2.62.7-2.01.92.6-2.51.82.91.7
Zn content in liver0.40.51.3-0.7-0.50.3-0.30.50.5-0.80.4-0.91.00.4-0.41.0-0.5-1.1
Bone: minimum diameter3.26.28.02.72.7-2.72.7-2.7-2.62.8-2.62.5-2.5-2.62.5-2.5-2.0-0.1
Time in familiar zone, hab. session 12.73.04.81.91.8-1.91.9-1.8-1.61.3-1.52.1-2.2-1.51.6-2.2-0.41.4
Time in novel zone, hab. session 12.32.63.4-1.6-1.81.8-1.81.71.6-1.21.6-1.81.81.6-1.51.81.0-0.6
Total zone transitions, hab. session 10.50.81.70.50.5-0.70.7-0.5-0.50.6-0.81.2-1.3-0.90.8-1.30.91.1
Total locomotion distance, hab. session 10.20.31.40.30.2-0.20.2-0.1-0.10.2-0.40.7-0.8-0.40.2-0.81.01.2
Locomotion velocity, hab. session 10.10.20.70.20.1-0.20.2-0.1-0.10.1-0.40.6-0.6-0.40.2-0.70.80.8
Time in familiar zone, hab. session 23.23.75.12.22.0-2.12.1-2.1-2.01.7-2.01.6-1.6-1.92.0-1.5-2.3-1.2
Time in novel zone, hab. session 22.12.33.1-1.7-1.61.8-1.81.61.6-1.31.6-1.41.41.6-1.61.31.60.5
Total zone transitions, hab. session 22.02.53.71.31.5-1.61.6-1.5-1.41.8-1.71.9-1.9-1.81.6-1.9-0.31.1
Total locomotion distance, hab. session 20.20.32.4-0.4-0.00.0-0.00.10.10.1-0.10.3-0.4-0.2-0.1-0.40.91.5
Locomotion velocity, hab. session 20.20.32.7-0.5-0.20.2-0.20.20.3-0.10.00.2-0.3-0.0-0.2-0.31.11.6
Novel to familiar place preference ratio0.00.00.10.10.1-0.20.2-0.2-0.20.3-0.10.1-0.1-0.10.1-0.0-0.3-0.1
Novelty place preference0.10.10.30.40.4-0.40.4-0.4-0.40.5-0.30.3-0.3-0.30.3-0.3-0.4-0.0
Time in novel zone, NPP test0.10.20.30.40.5-0.50.5-0.5-0.40.6-0.40.4-0.4-0.40.3-0.3-0.50.0
Total zone transitions, NPP test0.30.41.20.50.5-0.50.5-0.4-0.40.4-0.70.8-0.8-0.80.8-0.80.31.1
Total locomotion distance, NPP test0.30.40.70.60.7-0.50.5-0.6-0.60.7-0.80.7-0.7-0.90.8-0.7-0.30.3
Locomotion velocity, NPP test0.30.40.80.70.6-0.50.5-0.6-0.50.8-0.80.7-0.8-0.90.8-0.8-0.10.5
Intraocular pressure0.00.10.2-0.0-0.30.2-0.20.30.2-0.30.3-0.10.20.3-0.10.10.3-0.4
Delta distance traveled before/after self-admin1.92.12.7-1.2-1.61.5-1.51.61.6-1.21.6-1.71.71.6-1.61.71.00.4
Delta ambulatory time before/after self-admin0.91.62.1-1.2-1.41.4-1.41.41.4-1.11.3-1.41.41.3-1.31.41.00.5
Parametrial fat weight1.73.95.0-1.9-2.02.2-2.22.02.1-2.12.0-2.12.12.0-2.12.11.40.8
Pavlov. Cond. lever latency0.10.10.30.0-0.40.3-0.30.40.4-0.20.5-0.30.30.5-0.30.30.5-0.1
Pavlov. Cond. magazine entry latency0.60.81.4-1.2-0.91.1-1.10.90.8-1.00.8-1.11.10.7-0.81.10.2-0.4
Pavlov. Cond. change in total contacts0.30.30.5-0.7-0.60.4-0.40.50.6-0.70.5-0.50.50.5-0.50.50.50.5
Pavlov. Cond. index score0.30.40.9-0.9-0.60.6-0.60.60.6-0.70.5-0.60.60.4-0.60.60.40.3
Pavlov. Cond. latency score0.20.30.8-0.9-0.50.5-0.50.40.5-0.60.3-0.50.50.3-0.50.50.20.3
Pavlov. Cond. lever contacts0.10.20.60.00.4-0.40.4-0.5-0.40.4-0.50.2-0.2-0.50.3-0.2-0.8-0.1
Pavlov. Cond. magazine entry number0.20.30.70.80.5-0.50.5-0.5-0.50.6-0.40.6-0.6-0.40.4-0.6-0.10.1
Pavlov. Cond. intertrial magazine entries0.30.42.70.2-0.40.2-0.20.40.50.10.40.2-0.20.3-0.2-0.31.51.6
Pavlov. Cond. lever-magazine prob. diff.0.30.40.8-0.9-0.60.6-0.60.60.6-0.70.5-0.60.60.5-0.60.60.30.3
Pavlov. Cond. response bias0.10.10.3-0.4-0.00.1-0.1-0.0-0.0-0.2-0.1-0.30.3-0.10.00.3-0.5-0.6
Pavlov. Cond. lever latency0.30.51.10.00.5-1.11.1-0.7-0.60.2-0.80.7-0.6-0.80.7-0.6-0.50.4
Pavlov. Cond. magazine entry latency0.70.91.7-0.5-0.91.3-1.31.00.9-0.71.0-1.11.11.1-1.11.10.5-0.3
Pavlov. Cond. change in total contacts0.10.21.01.00.40.0-0.0-0.3-0.30.8-0.10.4-0.40.00.3-0.50.1-0.4
Pavlov. Cond. index score0.10.20.80.3-0.20.7-0.70.20.20.20.3-0.30.30.4-0.30.30.0-0.9
Pavlov. Cond. latency score0.30.51.2-0.1-0.61.1-1.10.70.6-0.30.8-0.80.80.8-0.70.80.3-0.9
Pavlov. Cond. lever contacts0.10.20.60.3-0.20.7-0.70.30.30.10.4-0.40.30.5-0.40.30.2-0.7
Pavlov. Cond. magazine entry number0.50.61.10.20.7-1.01.0-0.8-0.70.7-0.90.8-0.8-0.90.9-0.8-0.40.4
Pavlov. Cond. intertrial magazine entries2.14.65.92.22.2-2.42.4-2.2-2.22.2-2.32.2-2.2-2.32.3-2.2-1.6-0.6
Pavlov. Cond. lever-magazine prob. diff.0.20.30.70.2-0.30.9-0.90.40.3-0.00.5-0.40.40.5-0.50.40.2-0.8
Pavlov. Cond. response bias0.20.20.90.80.40.2-0.2-0.3-0.40.7-0.30.3-0.3-0.20.3-0.3-0.4-0.9
Time in closed arm before self-admin0.61.01.31.01.0-1.21.2-1.0-1.01.2-1.01.0-1.0-0.90.9-1.0-0.9-0.5
Time in closed arm after self-admin0.20.20.90.30.2-0.40.4-0.3-0.30.1-0.50.1-0.0-0.50.5-0.0-0.7-0.9
Time in open arm before self-admin2.02.44.0-2.0-1.61.7-1.71.61.6-1.81.5-1.61.61.4-1.41.61.20.7
Time in open arm after self-admin0.30.30.8-0.9-0.40.6-0.60.50.5-0.20.6-0.30.20.6-0.60.20.80.9
Bone: periosteal estimation2.04.86.02.42.5-2.42.4-2.4-2.32.4-2.22.2-2.2-2.12.0-2.1-2.1-0.4
Bone: periosteal perimeter1.63.14.32.12.0-1.91.9-1.9-1.92.0-1.71.8-1.8-1.61.5-1.8-1.5-0.2
Bone: post-yield work3.15.47.42.62.4-2.72.7-2.5-2.42.4-2.32.0-1.9-2.22.1-1.9-2.6-1.5
Progressive ratio test 1 active lever presses0.40.71.5-1.20.8-0.80.8-0.8-0.80.5-0.81.1-1.1-0.80.8-1.1-0.10.7
Progressive ratio test 1 breakpoint0.40.71.2-1.10.8-0.80.8-0.8-0.80.4-0.81.1-1.1-0.80.8-1.1-0.20.7
Progressive ratio test 1 inactive lever presses1.33.34.60.82.0-1.81.8-2.0-2.01.5-2.12.0-2.0-2.12.1-2.0-1.4-0.5
Progressive ratio test 2 active lever presses0.50.71.6-0.61.0-0.90.9-0.9-1.00.4-0.80.7-0.6-0.80.8-0.6-1.3-0.6
Progressive ratio test 2 breakpoint0.60.81.9-0.41.1-1.01.0-1.0-1.10.5-0.90.7-0.7-0.90.9-0.7-1.4-0.7
Progressive ratio test 2 inactive lever presses1.34.15.10.92.3-2.22.2-2.3-2.31.8-2.22.2-2.2-2.22.2-2.1-1.8-0.8
Incentive Sensitization - Responses0.82.14.41.11.7-1.61.6-1.6-1.61.3-1.41.1-1.1-1.41.4-1.0-2.1-1.4
Incentive Sensitization - Breakpoint0.71.53.60.91.4-1.31.3-1.3-1.31.1-1.20.9-0.8-1.11.1-0.8-1.9-1.3
Sum of active levers in priming session hrs 5-60.10.10.4-0.1-0.20.2-0.20.20.20.30.30.0-0.10.3-0.3-0.10.60.6
Progressive ratio0.00.10.30.2-0.10.1-0.10.10.10.4-0.10.2-0.2-0.20.0-0.20.50.6
Food seeking constrained by brief footshock1.21.59.9-0.9-0.40.5-0.50.30.40.20.20.9-1.10.1-0.2-1.22.83.1
Seeking ratio, punishment vs. effort0.20.51.10.50.7-0.60.6-0.7-0.60.5-0.51.0-1.0-0.50.6-1.00.20.6
Retroperitoneal fat weight3.616.121.8-3.9-4.14.4-4.44.14.0-4.34.1-4.64.64.2-4.24.72.00.4
Reaction time number correct0.10.30.5-0.1-0.30.6-0.60.50.5-0.40.5-0.40.30.6-0.60.30.70.7
Reaction time mean minus median0.00.00.2-0.40.1-0.10.1-0.0-0.0-0.0-0.10.0-0.0-0.1-0.2-0.0-0.0-0.2
Reaction time mean minus median AUC0.00.10.5-0.70.1-0.10.10.00.0-0.10.0-0.10.10.0-0.30.1-0.2-0.3
Reaction time num false alarms0.10.11.0-1.00.1-0.30.30.0-0.0-0.20.10.0-0.00.2-0.2-0.00.0-0.4
Reaction time num false alarms AUC0.20.43.0-1.7-0.40.2-0.20.50.5-0.70.6-0.30.20.7-0.70.20.80.3
Reaction time trials correct on left0.10.30.5-0.1-0.30.6-0.60.50.5-0.40.5-0.40.30.6-0.60.30.70.7
Reaction time trials on left0.10.30.5-0.2-0.30.6-0.60.50.5-0.40.5-0.30.30.6-0.60.30.70.7
Reaction time mean0.61.22.71.01.0-1.21.2-1.1-1.11.0-1.10.8-0.8-1.11.1-0.8-1.3-1.6
Reaction time mean AUC0.20.62.30.50.6-0.80.8-0.7-0.70.5-0.70.4-0.3-0.70.7-0.3-1.1-1.5
Median of all reaction times0.81.33.51.21.0-1.11.1-1.0-1.10.9-1.10.8-0.7-1.11.2-0.7-1.4-1.9
Reaction time omissions0.10.10.8-0.9-0.1-0.00.00.30.3-0.40.30.0-0.00.4-0.5-0.10.70.1
Reaction time false alarm rate0.10.21.9-1.4-0.2-0.10.10.30.2-0.40.3-0.00.00.4-0.3-0.00.5-0.1
Reaction time premature initiation rate0.00.10.30.50.2-0.40.4-0.2-0.20.2-0.30.1-0.0-0.30.3-0.0-0.4-0.2
Reaction time premature initiations0.00.00.10.3-0.00.1-0.10.10.1-0.20.1-0.30.30.1-0.10.3-0.10.0
Std. dev. reaction times0.20.71.20.50.9-1.01.0-0.9-0.90.8-0.90.7-0.6-0.90.7-0.6-1.1-1.0
Reaction time trials completed0.10.30.5-0.2-0.30.6-0.60.50.5-0.40.5-0.30.30.6-0.60.30.70.7
Reaction time trials AUC0.10.20.4-0.1-0.20.5-0.50.40.4-0.30.4-0.30.30.5-0.60.30.50.6
Run reversals in cocaine runway, females0.40.51.1-0.50.6-0.70.7-0.7-0.70.7-0.70.4-0.4-0.80.8-0.3-1.0-0.9
Run reversals in cocaine runway, males0.00.00.10.10.1-0.10.1-0.1-0.1-0.3-0.00.1-0.00.00.2-0.0-0.2-0.4
Latency to leave start box in cocaine runway0.40.60.70.50.8-0.80.8-0.8-0.80.7-0.80.8-0.8-0.80.9-0.8-0.7-0.8
Latency to leave start box in cocaine runway, F0.10.10.2-0.10.3-0.30.3-0.3-0.30.1-0.30.3-0.3-0.30.3-0.3-0.3-0.4
Latency to leave start box in cocaine runway, M1.51.41.71.01.3-1.31.3-1.3-1.31.1-1.21.2-1.1-1.11.2-1.2-1.1-1.0
Std. dev. time between licks in bursts0.30.53.1-0.1-0.50.6-0.60.60.6-0.30.50.0-0.10.5-0.2-0.21.81.4
Total sessions with >9 infusions0.81.01.5-1.21.0-1.11.1-1.1-1.00.6-1.01.2-1.2-1.01.0-1.2-0.50.4
Short access day 1 total inactive lever presses0.51.12.20.81.2-1.11.1-1.1-1.10.7-1.10.8-0.7-1.01.0-0.7-1.5-1.0
Short access day 10 total inactive lever presses0.10.43.31.80.6-0.50.5-0.5-0.50.3-0.50.4-0.4-0.40.4-0.4-0.5-0.6
Short access day 1 total infusions0.00.10.7-0.80.0-0.00.0-0.0-0.1-0.4-0.10.1-0.1-0.10.1-0.10.00.1
Short access day 10 total infusions0.10.11.0-1.0-0.10.2-0.20.10.1-0.50.1-0.00.00.1-0.10.00.20.5
Short access total infusions0.20.33.0-1.7-0.20.3-0.30.20.2-0.90.2-0.20.20.2-0.20.20.20.3
Short access day 1 locomotion0.30.50.7-0.90.7-0.80.8-0.7-0.70.1-0.80.6-0.6-0.70.7-0.5-0.9-0.1
Short access day 10 total locomotion0.20.71.80.40.9-0.80.8-0.8-0.80.5-0.71.2-1.3-0.70.7-1.30.30.9
Short access total locomotion0.40.62.5-1.60.3-0.40.4-0.3-0.3-0.2-0.30.8-0.9-0.20.2-0.90.71.5
One hour access (0.3 mA shock)3.84.66.11.22.5-2.42.4-2.4-2.41.9-2.22.2-2.2-2.22.2-2.2-2.2-1.0
Compulsive drug intake1.72.56.92.61.7-1.51.5-1.6-1.61.8-1.41.5-1.5-1.41.4-1.5-1.3-0.9
One hour access (shock baseline)0.20.61.5-1.20.7-0.70.7-0.7-0.80.1-0.80.4-0.4-0.80.8-0.4-1.2-0.7
Social response proportion1.11.32.71.41.1-1.21.2-1.1-1.11.0-1.20.7-0.7-1.21.2-0.7-1.5-1.6
Social responses3.14.15.21.92.1-2.22.2-2.1-2.12.0-2.21.9-1.8-2.22.3-1.8-1.9-1.5
Social time2.64.16.01.72.0-2.02.0-2.0-2.02.3-2.22.4-2.4-2.32.2-2.4-0.60.7
Soleus weight0.00.10.3-0.10.5-0.50.5-0.4-0.40.4-0.20.3-0.3-0.10.1-0.3-0.50.5
Bone: stiffness2.54.55.42.32.3-2.32.3-2.3-2.32.0-2.22.1-2.1-2.12.2-2.1-2.0-1.0
Tibialis anterior weight0.72.44.1-1.8-1.31.5-1.51.31.4-1.41.7-1.71.71.9-2.01.80.41.0
Time to tail flick, vehicle, before self-admin0.30.40.70.90.6-0.50.5-0.6-0.50.7-0.50.8-0.8-0.50.5-0.90.10.2
Time to tail flick, vehicle, after self-admin0.30.72.91.70.8-0.80.8-0.7-0.80.4-0.60.4-0.4-0.60.6-0.4-1.1-1.1
Time to tail flick, test, before self-admin0.50.62.7-1.0-0.50.4-0.40.50.5-0.90.60.1-0.10.7-0.7-0.21.41.7
Time to tail flick, test, after self-admin0.20.21.2-1.1-0.50.5-0.50.40.4-0.10.3-0.50.60.3-0.30.60.1-0.1
Delta time to tail flick, vehicle, before/after SA0.20.20.80.8-0.1-0.00.00.10.1-0.80.2-0.50.50.3-0.30.5-0.6-0.9
Delta time to tail flick, test, before/after SA0.30.41.40.10.3-0.30.3-0.4-0.40.9-0.60.00.0-0.70.70.1-1.1-1.2
Tibia length3.710.412.92.93.5-3.33.3-3.5-3.43.6-3.53.1-3.1-3.53.4-3.0-3.1-1.1
Ambulatory time before self-admin0.51.53.40.51.1-1.11.1-1.1-1.11.5-1.01.7-1.8-1.01.0-1.80.41.0
Ambulatory time after self-admin0.30.42.3-0.7-0.20.1-0.10.20.20.80.20.5-0.50.2-0.2-0.61.31.5
Bone: tissue strength0.40.43.9-0.00.3-0.40.4-0.2-0.1-0.0-0.20.6-0.7-0.20.1-0.70.72.0
Total heroin consumption0.10.10.2-0.2-0.10.3-0.30.20.20.20.3-0.00.00.3-0.30.00.40.5
Bone: trabecular number0.10.30.8-0.9-0.50.5-0.50.50.5-0.60.4-0.40.40.4-0.30.40.60.5
Bone: trabecular spacing0.00.00.0-0.10.00.0-0.0-0.1-0.00.0-0.0-0.10.1-0.0-0.10.1-0.20.2
Bone: trabecular thickness0.00.00.1-0.40.0-0.20.2-0.1-0.10.0-0.00.1-0.1-0.00.1-0.0-0.1-0.1
Bone: trabecular tissue density0.50.81.5-1.2-0.90.9-0.90.90.9-0.70.8-1.21.20.8-0.81.20.1-0.5
Water consumed over 24 hours0.51.01.60.81.1-1.01.0-1.0-1.00.9-1.11.2-1.2-1.11.2-1.2-0.30.5
Number of responses in last shaping day0.10.11.0-1.00.0-0.10.1-0.1-0.1-0.4-0.3-0.10.1-0.30.30.1-0.5-0.4