Hub : Genes

Kmt2d

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Kmt2d 0.08 0.06 6.8e-09 0.09 0.09 0.08 0.09 1.2e-08 5.5e-09 4.3e-08 1.3e-08
2 BLA gene expression Kmt2d 0.16 0.12 3.4e-08 0.13 0.15 0.13 0.14 1.7e-07 2.8e-08 3.1e-07 1.3e-07
3 NAcc intron excision ratio chr7_131854309_131859157 0.06 0.05 8.4e-08 0.05 0.05 0.03 0.05 7.9e-08 5.5e-08 7.6e-06 8.3e-08
4 NAcc intron excision ratio chr7_131862597_131862698 0.02 0.02 2.3e-03 0.01 0.02 0.01 0.01 2.2e-03 1.4e-03 1.5e-02 3.0e-03
5 LHb gene expression Kmt2d 0.19 0.17 2.8e-03 0.06 0.05 0.04 0.04 1.9e-02 2.8e-02 4.1e-02 5.0e-02
6 PL isoform ratio NM_001427309.1 0.06 0.07 1.3e-05 0.05 0.04 0.03 0.04 8.9e-06 3.3e-05 1.7e-04 3.6e-05
7 PL alternative TSS NM_001427309.1 0.05 0.05 5.3e-05 0.04 0.03 0.04 0.04 2.1e-05 3.5e-04 6.0e-05 4.0e-05
8 PL alternative TSS XM_063262841.1 0.05 0.05 9.8e-05 0.04 0.03 0.04 0.04 1.3e-05 2.6e-04 8.6e-05 9.8e-05
9 PL alternative TSS XM_063262841.1 0.04 0.04 3.7e-04 0.04 0.02 0.03 0.03 4.7e-05 1.1e-03 1.3e-04 2.6e-04
10 PL gene expression Kmt2d 0.12 0.11 1.7e-09 0.08 0.08 0.07 0.08 2.8e-09 4.8e-09 1.4e-08 5.8e-09
11 pVTA gene expression Kmt2d 0.17 0.2 1.1e-07 0.09 0.09 0.08 0.09 8.2e-08 8.9e-08 3.6e-07 8.7e-08
12 NAcc gene expression Kmt2d 0.03 0.03 3.2e-05 0.03 0.03 0.02 0.02 5.4e-05 5.7e-05 4.9e-04 1.0e-04
13 IC gene expression Kmt2d 0.11 0.1 4.7e-04 0.04 0.04 0.04 0.04 5.8e-03 7.7e-03 7.0e-03 1.3e-02
14 PL isoform ratio XM_017595321.3 0.03 0.04 2.2e-03 0.02 0.02 0.02 0.01 3.2e-03 5.2e-03 6.4e-03 3.7e-02
15 PL alternative TSS NM_001427309.1 0.05 0.06 9.0e-05 0.04 0.03 0.04 0.04 7.7e-05 4.7e-04 7.0e-05 9.8e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density9.215.818.2-4.2-4.2-4.24.2-4.3-4.2-4.24.24.2-4.2-4.3-4.0-4.13.0-0.5
Area under the delay curve0.60.71.1-0.9-0.9-0.90.9-1.0-0.8-0.80.80.8-0.8-0.8-1.0-1.10.80.4
BMI with tail6.221.326.1-4.9-4.9-4.84.9-4.8-4.7-4.74.74.7-4.7-4.8-4.7-5.14.0-0.5
BMI without tail1.54.76.3-2.4-2.4-2.22.4-2.2-2.1-2.12.12.1-2.1-2.3-2.0-2.52.3-0.1
Body weight6.327.532.6-5.6-5.6-5.45.6-5.4-5.4-5.45.45.4-5.4-5.3-5.2-5.74.9-1.7
Weight adjusted by age2.53.87.3-1.9-2.0-1.92.0-1.9-1.8-1.81.81.8-1.8-1.9-1.8-2.12.7-1.7
Bone surface11.220.324.2-4.7-4.7-4.74.7-4.9-4.8-4.84.84.8-4.8-4.7-4.6-4.53.4-1.8
Bone volume8.615.418.5-4.1-4.1-4.14.1-4.3-4.2-4.24.24.2-4.2-4.1-3.9-3.92.9-1.2
Breakpoint value in progressive ratio session1.21.42.1-1.3-1.3-1.31.3-1.2-1.1-1.11.11.1-1.1-1.1-1.5-1.31.2-0.7
Number of licking bursts0.30.40.70.60.60.7-0.60.70.80.8-0.8-0.80.80.70.90.20.30.1
Context. condit. distance diff. score0.30.30.6-0.6-0.6-0.50.6-0.5-0.5-0.50.50.5-0.5-0.4-0.6-0.80.8-0.6
Locomotion velocity, session 10.80.92.11.01.00.9-1.00.80.90.9-0.9-0.90.91.00.91.0-0.7-1.4
Locomotion distance, session 12.83.55.31.91.91.8-1.91.91.81.8-1.8-1.81.81.91.62.0-2.31.7
Locomotion velocity, session 20.20.30.70.50.50.5-0.50.50.50.5-0.5-0.50.50.40.50.5-0.70.8
Locomotion distance, session 22.12.94.31.81.81.7-1.81.71.71.7-1.7-1.71.71.71.61.9-2.10.7
Locomotion velocity, session 33.74.24.82.22.22.2-2.22.12.12.1-2.1-2.12.12.12.12.2-2.10.9
Locomotion distance, session 34.65.06.32.42.42.4-2.42.22.22.2-2.2-2.22.22.22.42.5-2.31.0
Stereotopy head waving bouts, day 31.51.83.4-1.2-1.2-1.21.2-1.4-1.4-1.41.41.4-1.4-1.4-1.0-1.11.5-1.9
Stereotopy head waving duration, day 30.91.13.6-0.9-0.9-0.90.9-1.0-1.0-1.01.01.0-1.0-1.0-0.8-0.70.9-1.9
Locomotion velocity, session 70.20.21.20.50.50.5-0.50.30.20.2-0.2-0.20.20.30.60.5-0.1-1.1
Locomotion distance, session 71.21.62.61.41.41.5-1.41.31.11.1-1.1-1.11.11.31.61.3-0.8-0.8
Stereotopy head waving bouts, day 71.92.16.3-1.3-1.3-1.21.3-1.4-1.3-1.31.31.3-1.3-1.3-1.1-1.21.9-2.5
Stereotopy head waving duration, day 71.41.74.4-1.2-1.2-1.11.2-1.3-1.2-1.21.21.2-1.2-1.2-1.1-1.11.5-2.1
Locomotion velocity, session 80.00.00.1-0.0-0.1-0.00.10.10.10.1-0.1-0.10.10.0-0.1-0.20.10.3
Locomotion distance, session 81.11.52.31.31.31.2-1.31.31.31.3-1.3-1.31.31.31.11.2-1.50.4
Degree of sensitization distance0.60.61.1-0.7-0.7-0.70.7-0.7-0.8-0.80.80.8-0.8-0.7-0.6-0.81.0-1.1
Degree of sensitization stereotypy0.40.43.1-0.4-0.4-0.30.4-0.5-0.4-0.40.40.4-0.4-0.3-0.2-0.51.1-1.8
Conditioned locomotion0.40.56.2-0.1-0.1-0.10.1-0.2-0.3-0.30.30.3-0.3-0.2-0.0-0.10.8-2.5
Cocaine response after cond. corrected0.40.56.30.10.10.1-0.10.10.10.1-0.1-0.10.10.00.10.0-0.92.5
Cocaine response after cond. not corrected0.91.14.80.80.90.8-0.90.80.80.8-0.8-0.80.80.80.80.8-1.52.2
Cocaine response before conditioning3.44.15.12.12.22.1-2.22.02.12.1-2.1-2.12.12.12.02.3-1.7-0.5
Saline control response0.10.10.5-0.1-0.1-0.20.1-0.3-0.3-0.30.30.3-0.3-0.2-0.20.0-0.2-0.7
Bone: connectivity density6.39.911.8-3.3-3.3-3.33.3-3.4-3.4-3.43.43.4-3.4-3.4-3.2-3.22.1-0.5
Bone: cortical apparent density0.20.20.30.50.50.4-0.50.40.50.5-0.5-0.50.50.40.40.6-0.30.6
Bone: cortical area11.016.918.8-4.3-4.3-4.14.3-4.3-4.3-4.34.34.3-4.3-4.1-4.0-4.33.8-2.6
Bone: cortical porosity0.70.71.60.91.00.8-1.00.60.70.7-0.7-0.70.70.80.71.3-1.1-0.8
Bone: cortical porosity0.91.01.91.11.11.0-1.10.70.80.8-0.8-0.80.80.90.91.4-1.1-1.1
Bone: cortical thickness4.27.09.9-2.8-2.8-2.62.8-2.8-2.7-2.72.72.7-2.7-2.5-2.4-3.12.6-1.3
Bone: cortical thickness0.20.20.7-0.4-0.4-0.30.4-0.5-0.4-0.40.40.4-0.4-0.3-0.1-0.60.8-0.8
Bone: cortical tissue density0.30.30.40.60.60.5-0.60.50.60.6-0.6-0.60.60.50.50.7-0.40.6
Condit. Reinf. active minus inactive responses0.10.10.50.20.20.2-0.20.10.10.1-0.1-0.10.10.20.20.4-0.70.3
Condit. Reinf. active-inactive response ratio0.30.30.4-0.5-0.5-0.60.5-0.7-0.6-0.60.60.6-0.6-0.6-0.6-0.2-0.10.5
Condit. Reinf. active responses0.50.61.20.80.80.8-0.80.70.80.8-0.8-0.80.80.80.80.8-1.10.3
Condit. Reinf. inactive responses2.63.23.71.91.81.9-1.91.91.91.9-1.9-1.91.91.91.91.6-1.60.1
Incentive salience index mean0.00.00.0-0.2-0.2-0.10.2-0.2-0.2-0.20.20.2-0.2-0.1-0.1-0.2-0.10.1
Condit. Reinf. lever presses0.10.10.4-0.4-0.4-0.40.4-0.3-0.3-0.30.30.3-0.3-0.3-0.3-0.60.4-0.1
Condit. Reinf. active minus inactive responses0.00.00.10.10.20.1-0.20.10.20.2-0.2-0.20.20.10.10.4-0.10.0
Condit. Reinf. active-inactive response ratio0.30.40.50.60.60.6-0.60.70.70.7-0.7-0.70.70.60.60.7-0.50.5
Condit. Reinf. active responses0.20.30.60.50.50.5-0.50.50.50.5-0.5-0.50.50.40.50.7-0.50.4
Condit. Reinf. inactive responses0.50.60.90.80.90.8-0.90.80.80.8-0.8-0.80.80.80.81.0-0.60.2
Condit. Reinf. lever presses0.00.00.4-0.1-0.1-0.10.1-0.0-0.1-0.10.10.1-0.1-0.2-0.1-0.10.00.7
Condit. Reinf. lever reinforcers received0.50.71.10.80.90.8-0.90.80.80.8-0.8-0.80.80.70.81.0-0.70.6
Conditioned reinforcement - actives0.91.52.21.31.31.4-1.31.31.21.2-1.2-1.21.21.41.51.1-0.8-0.4
Conditioned reinforcement - inactives3.55.16.92.42.42.5-2.42.22.32.3-2.3-2.32.32.52.62.2-2.0-0.1
Conditioned locomotion0.20.31.90.50.50.5-0.50.50.40.4-0.4-0.40.40.40.50.5-0.1-1.4
Patch foraging indifference point 0 sec1.83.44.11.91.92.0-1.91.91.91.9-1.9-1.91.92.01.91.8-1.80.6
Patch foraging indifference point AUC0.60.91.31.01.11.1-1.10.90.90.9-0.9-0.90.91.11.10.9-0.9-0.4
Delay disc. indifference point, 0s delay1.31.42.5-1.1-1.1-1.11.1-1.3-1.2-1.21.21.2-1.2-1.1-1.1-1.21.1-1.6
Delay disc. indifference point, 16s delay0.70.81.2-0.9-0.9-0.90.9-0.9-0.8-0.80.80.8-0.8-0.8-0.9-1.11.1-0.4
Delay disc. indifference point, 2s delay1.11.21.6-1.2-1.2-1.21.2-1.1-1.1-1.11.11.1-1.1-1.2-1.3-1.11.1-0.1
Delay disc. indifference point, 24s delay1.01.21.6-1.1-1.1-1.11.1-1.1-1.0-1.01.01.0-1.0-1.0-1.2-1.31.2-0.9
Delay disc. indifference point, 4s delay0.40.41.8-0.6-0.6-0.60.6-0.4-0.5-0.50.50.5-0.5-0.6-0.6-0.60.21.3
Delay disc. indifference point, 8s delay1.72.03.0-1.5-1.5-1.51.5-1.6-1.4-1.41.41.4-1.4-1.4-1.4-1.71.40.5
Indifference point function ln k3.15.46.2-2.3-2.3-2.32.3-2.3-2.4-2.42.42.4-2.4-2.3-2.2-2.22.3-2.5
Indifference point function log k3.15.46.2-2.3-2.3-2.32.3-2.3-2.4-2.42.42.4-2.4-2.3-2.2-2.22.3-2.5
Patch foraging total patch changes 0 sec1.83.44.01.91.92.0-1.91.91.91.9-1.9-1.91.92.01.91.8-1.80.6
Patch foraging total patch changes 12 sec2.22.93.91.81.81.9-1.81.71.81.8-1.8-1.81.82.01.81.6-1.3-0.2
Patch foraging total patch changes 18 sec3.35.05.92.42.42.4-2.42.22.32.3-2.3-2.32.32.32.42.4-2.20.5
Patch foraging total patch changes 24 sec1.52.53.21.71.71.8-1.71.61.61.6-1.6-1.61.61.71.71.6-1.1-0.9
Patch foraging total patch changes 6 sec2.43.74.22.02.02.0-2.02.01.91.9-1.9-1.91.92.02.01.9-1.91.2
Patch foraging time to switch 0 sec1.93.84.21.91.91.9-1.92.02.12.1-2.1-2.12.11.91.72.0-1.71.9
Patch foraging water rate 0 sec2.65.46.2-2.4-2.4-2.32.4-2.4-2.4-2.42.42.4-2.4-2.3-2.1-2.52.3-2.0
Patch foraging water rate 12 sec2.75.66.2-2.4-2.4-2.32.3-2.3-2.5-2.52.52.5-2.5-2.4-2.3-2.22.3-1.9
Patch foraging water rate 18 sec0.30.40.8-0.7-0.7-0.60.7-0.6-0.6-0.60.60.6-0.6-0.6-0.6-0.80.9-0.3
Patch foraging water rate 24 sec3.04.26.0-2.1-2.1-2.12.1-1.9-2.0-2.02.02.0-2.0-2.2-2.0-2.02.4-1.6
Patch foraging water rate 6 sec4.46.47.0-2.5-2.5-2.52.5-2.6-2.6-2.62.62.6-2.6-2.6-2.3-2.52.6-2.2
Seeking ratio, delayed vs. immediate footshock0.10.20.9-0.4-0.4-0.30.3-0.3-0.4-0.40.40.4-0.4-0.3-0.4-0.5-0.30.9
Distance traveled before self-admin0.70.91.11.01.01.0-1.01.01.11.1-1.1-1.11.10.91.00.9-0.50.4
Distance traveled after self-admin0.30.31.00.50.50.5-0.50.50.50.5-0.5-0.50.50.40.60.5-0.91.0
Extensor digitorum longus weight3.714.719.6-4.0-4.1-3.94.1-3.9-3.8-3.83.83.8-3.8-3.6-3.8-4.44.2-2.2
Bone: elastic displacement4.55.36.02.32.32.1-2.22.42.42.4-2.4-2.42.42.21.92.4-2.12.3
Bone: elastic work0.00.10.4-0.1-0.0-0.30.1-0.1-0.0-0.00.00.0-0.0-0.2-0.40.3-0.20.7
Bone: endosteal estimation7.917.418.8-4.3-4.2-4.34.3-4.3-4.3-4.34.34.3-4.3-4.3-4.3-3.93.8-3.0
Bone: endosteal perimeter7.115.016.1-4.0-4.0-3.94.0-4.0-4.0-4.04.04.0-4.0-3.8-3.8-3.93.7-2.8
Epididymis fat weight0.82.83.3-1.7-1.7-1.81.7-1.7-1.8-1.81.81.8-1.8-1.8-1.7-1.51.3-0.9
Delta time in closed arm before/after self-admin0.00.00.30.10.10.1-0.10.10.00.0-0.0-0.00.00.1-0.00.3-0.50.1
Delta time in open arm before/after self-admin1.01.01.31.11.01.1-1.01.01.11.1-1.1-1.11.11.11.11.0-0.60.2
Diff in mean of infusions in LGA sessions0.91.11.4-1.1-1.1-1.21.1-1.0-1.0-1.01.01.0-1.0-1.2-1.1-0.90.8-0.2
Delay discount exponential model param0.60.61.00.90.90.8-0.90.80.70.7-0.7-0.70.70.80.91.0-0.8-0.6
Extinction: sum of active levers before priming1.61.82.7-1.4-1.4-1.41.4-1.2-1.3-1.31.31.3-1.3-1.3-1.4-1.31.3-1.6
Active lever presses in extinction session 61.31.31.6-1.1-1.1-1.11.1-1.2-1.3-1.31.31.3-1.3-1.1-1.1-1.20.8-0.8
Bone: final force10.717.220.3-4.3-4.3-4.34.3-4.5-4.3-4.34.34.3-4.3-4.2-4.3-4.23.4-2.3
Bone: final moment11.518.521.8-4.5-4.5-4.54.5-4.7-4.5-4.54.54.5-4.5-4.4-4.5-4.33.4-2.3
Food consumed during 24 hour testing period1.42.02.4-1.5-1.5-1.51.5-1.5-1.5-1.51.51.5-1.5-1.5-1.4-1.40.7-0.1
Glucose0.20.31.3-0.5-0.5-0.40.5-0.0-0.2-0.20.20.2-0.2-0.3-0.4-0.70.91.1
Heart weight0.10.21.2-0.3-0.3-0.30.3-0.2-0.2-0.20.20.2-0.2-0.3-0.3-0.50.11.1
Delay discount hyperbolic model param0.60.70.90.90.90.8-0.90.80.70.7-0.7-0.70.70.80.91.0-0.7-1.0
Intermittent access intake day 1-15 change0.00.10.20.30.30.4-0.30.30.20.2-0.2-0.20.20.20.50.0-0.40.3
Intermittent access intake escalation0.00.00.00.10.10.1-0.10.1-0.0-0.00.00.0-0.0-0.00.2-0.2-0.20.2
Intermittent access intake escalation 20.20.21.30.40.40.5-0.40.40.40.4-0.4-0.40.40.30.60.1-0.51.1
Intermitt. access day 1 inactive lever presses0.41.34.71.11.11.0-1.11.21.11.1-1.1-1.11.11.20.81.3-0.5-2.2
Intermitt. access day 15 inactive lever presses0.61.31.71.21.21.2-1.21.31.11.1-1.1-1.11.11.21.31.1-1.1-0.9
Intermitt. access escalation Index0.40.61.5-0.8-0.8-0.80.8-0.7-0.5-0.50.50.5-0.5-0.8-0.9-0.81.11.2
Intermittent access day 1 total infusions0.91.41.51.21.21.2-1.21.11.21.2-1.2-1.21.21.21.21.0-1.11.1
Intermittent access day 15 total infusions0.71.11.61.11.11.2-1.11.11.11.1-1.1-1.11.11.11.30.7-0.70.6
Intermittent access terminal intake (last 3 days)1.21.52.21.31.31.4-1.31.21.31.3-1.3-1.31.31.21.51.0-1.00.9
Intermittent access total infusions1.82.22.91.51.51.6-1.51.41.51.5-1.5-1.51.51.51.71.1-1.11.2
Intermittent access day 1 locomotion0.10.10.30.40.30.4-0.30.30.40.4-0.4-0.40.40.40.30.30.1-0.6
Intermittent access day 15 total locomotion0.20.31.60.50.50.6-0.50.40.40.4-0.4-0.40.40.40.60.30.1-1.3
Intermittent access total locomotion1.21.41.81.31.31.3-1.31.11.21.2-1.2-1.21.21.21.31.1-0.6-0.8
Intermittent access standard deviation0.30.71.90.70.70.8-0.70.80.80.8-0.8-0.80.80.80.80.3-0.61.4
Left kidney weight0.83.54.3-2.0-2.0-1.92.0-2.1-1.9-1.91.91.9-1.9-2.0-1.8-2.01.01.7
Right kidney weight3.917.620.1-4.5-4.5-4.44.5-4.3-4.3-4.34.34.3-4.3-4.5-4.2-4.53.8-0.4
Cocaine induced anxiety2.83.94.8-2.0-2.0-2.02.0-1.9-2.0-2.02.02.0-2.0-1.9-1.9-2.22.1-1.8
Post-drug Anxiety3.43.64.5-1.9-1.9-1.91.9-1.8-2.0-2.02.02.0-2.0-1.9-1.9-2.11.7-1.5
Baseline Anxiety0.00.00.2-0.1-0.1-0.10.1-0.1-0.2-0.20.20.2-0.2-0.1-0.1-0.3-0.10.5
Tail length0.00.00.1-0.1-0.1-0.00.10.1-0.0-0.00.00.0-0.0-0.10.0-0.10.30.2
Length with tail1.66.87.4-2.7-2.7-2.62.7-2.5-2.7-2.72.72.7-2.7-2.5-2.5-2.72.7-1.8
Length without tail5.216.919.9-4.3-4.4-4.34.3-4.3-4.3-4.34.34.3-4.3-4.1-4.2-4.53.4-1.4
Times rat made contact with spout0.30.32.70.20.20.3-0.20.40.40.4-0.4-0.40.40.40.30.0-0.51.6
Lifetime Intake2.32.83.81.71.71.9-1.71.61.81.8-1.8-1.81.81.71.91.2-1.21.6
Liver weight, left9.515.717.7-4.1-4.1-4.04.1-4.2-4.1-4.14.14.1-4.1-4.1-3.9-4.23.8-1.7
Liver weight, right2.44.25.3-2.2-2.2-2.22.2-2.3-2.1-2.12.12.1-2.1-2.3-2.2-2.01.80.1
Locomotor activity1.11.82.81.41.41.5-1.41.21.41.4-1.4-1.41.41.31.71.3-0.8-0.0
Locomotor testing distance2.64.66.42.32.32.4-2.32.02.32.3-2.3-2.32.32.22.52.1-1.50.5
Locomotor testing rearing1.93.85.12.02.02.1-2.02.02.12.1-2.1-2.12.11.92.31.9-1.20.8
Locomotion in novel chamber1.41.82.5-1.3-1.3-1.31.3-1.2-1.4-1.41.41.4-1.4-1.2-1.2-1.31.5-1.6
Locomotion in novel chamber post-restriction0.00.00.10.20.20.2-0.20.20.10.1-0.1-0.10.10.10.20.1-0.1-0.3
Fecal boli incidents, locomotor time 11.82.64.31.51.51.6-1.51.71.51.5-1.5-1.51.51.61.51.4-1.92.1
Change in fecal boli incidents, locomotor task1.01.03.0-0.9-0.9-1.00.9-0.9-1.0-1.01.01.0-1.0-1.0-0.9-0.71.0-1.7
Time >=10cm from walls, locomotor time 10.20.22.4-0.2-0.2-0.20.2-0.2-0.1-0.10.10.1-0.1-0.3-0.2-0.30.01.5
Bouts of movement, locomotor time 10.10.11.00.00.0-0.00.00.10.10.1-0.1-0.10.1-0.1-0.20.2-0.21.0
Total resting periods, locomotor time 10.50.53.20.50.50.5-0.50.60.60.6-0.6-0.60.60.40.30.7-0.71.8
Rest time, locomotor task time 10.40.52.00.60.60.6-0.50.80.70.7-0.7-0.70.70.60.50.6-0.61.4
Distance moved, locomotor task time 10.10.10.4-0.2-0.1-0.20.1-0.1-0.3-0.30.30.3-0.3-0.2-0.2-0.10.2-0.7
Vertical activity count, locomotor time 10.71.72.3-1.3-1.3-1.21.2-1.3-1.5-1.51.51.5-1.5-1.2-1.1-1.40.9-0.7
Time >=10cm from walls, locomotor time 20.60.81.20.90.91.0-0.90.90.90.9-0.9-0.90.90.91.10.8-0.71.0
Bouts of movement, locomotor time 22.23.54.1-1.8-1.8-1.81.8-1.8-1.9-1.91.91.9-1.9-1.9-1.9-1.82.0-1.9
Total resting periods, locomotor time 22.23.94.6-1.9-1.9-1.91.9-1.9-2.0-2.02.02.0-2.0-2.0-2.0-1.92.1-2.1
Rest time, locomotor task time 20.00.00.4-0.1-0.1-0.10.10.20.10.1-0.1-0.10.10.0-0.1-0.20.00.6
Distance moved, locomotor task time 20.10.10.20.30.30.2-0.30.20.10.1-0.1-0.10.10.20.30.4-0.2-0.5
Vertical activity count, locomotor time 20.10.21.0-0.2-0.2-0.10.2-0.4-0.5-0.50.50.5-0.5-0.20.0-0.40.4-1.0
Light reinforcement 12.04.86.52.42.42.4-2.42.12.22.2-2.2-2.22.22.42.42.6-1.4-1.1
Light reinforcement 20.71.01.51.11.11.2-1.11.01.01.0-1.0-1.01.01.21.21.2-0.60.0
Bone: marrow area7.716.918.3-4.2-4.2-4.24.2-4.2-4.3-4.34.34.3-4.3-4.2-4.2-3.83.8-3.0
Bone: maximum diameter4.17.68.9-2.8-2.9-2.72.8-2.9-2.9-2.92.92.9-2.9-2.6-2.5-3.02.7-2.0
Bone: maximum force15.527.530.3-5.4-5.4-5.55.4-5.5-5.5-5.55.55.5-5.5-5.4-5.5-5.14.4-3.1
Bone: maximum moment16.428.832.4-5.6-5.5-5.75.5-5.6-5.6-5.65.65.6-5.6-5.6-5.7-5.14.4-3.1
Mean time between licks in bursts0.10.20.30.50.50.4-0.50.40.40.4-0.4-0.40.40.30.30.6-0.60.4
Mean num. licks in bursts0.10.21.7-0.1-0.0-0.20.0-0.1-0.1-0.10.10.1-0.1-0.1-0.30.2-1.01.3
Cd content in liver1.11.34.51.00.90.9-0.91.31.01.0-1.0-1.01.01.00.80.9-1.22.1
Co content in liver0.20.20.50.40.40.6-0.40.50.50.5-0.5-0.50.50.60.70.00.1-0.0
Cu content in liver1.11.32.5-1.2-1.3-1.21.3-1.2-1.0-1.01.01.0-1.0-1.1-1.2-1.61.20.5
Fe content in liver1.92.32.91.51.51.6-1.51.41.71.7-1.7-1.71.71.71.61.2-1.20.9
K content in liver0.00.00.3-0.1-0.2-0.10.2-0.2-0.0-0.00.00.0-0.00.1-0.1-0.60.50.1
Mg content in liver0.10.10.20.30.30.4-0.30.20.30.3-0.3-0.30.30.30.40.2-0.2-0.1
Mn content in liver0.00.00.20.00.1-0.0-0.10.10.00.0-0.0-0.00.0-0.1-0.10.30.1-0.4
Na content in liver0.10.10.10.20.10.2-0.10.30.30.3-0.3-0.30.30.30.1-0.30.4-0.1
Rb content in liver0.20.21.50.10.00.1-0.00.20.30.3-0.3-0.30.30.30.1-0.40.41.2
Se content in liver1.62.02.71.31.31.4-1.41.31.41.4-1.4-1.41.41.41.61.1-1.21.7
Sr content in liver1.71.51.7-1.2-1.2-1.21.2-1.3-1.2-1.21.21.2-1.2-1.2-1.1-1.31.3-1.3
Zn content in liver0.80.91.21.01.01.1-1.00.81.11.1-1.1-1.11.11.11.10.8-0.60.3
Bone: minimum diameter9.617.518.6-4.3-4.3-4.24.3-4.3-4.3-4.34.34.3-4.3-4.2-4.2-4.24.0-3.1
Time in familiar zone, hab. session 10.20.20.70.50.50.4-0.50.40.40.4-0.4-0.40.40.50.40.5-0.8-0.5
Time in novel zone, hab. session 10.70.75.3-0.5-0.5-0.50.5-0.7-0.7-0.70.70.7-0.7-0.5-0.4-0.51.0-2.3
Total zone transitions, hab. session 10.40.62.40.70.70.7-0.70.70.60.6-0.6-0.60.60.80.70.6-0.4-1.5
Total locomotion distance, hab. session 10.00.10.5-0.1-0.1-0.20.1-0.1-0.2-0.20.20.2-0.2-0.2-0.20.2-0.1-0.7
Locomotion velocity, hab. session 10.10.10.6-0.2-0.1-0.20.2-0.2-0.3-0.30.30.3-0.3-0.3-0.30.1-0.0-0.8
Time in familiar zone, hab. session 20.30.30.5-0.6-0.6-0.60.6-0.5-0.5-0.50.50.5-0.5-0.5-0.7-0.40.0-0.2
Time in novel zone, hab. session 20.20.20.80.50.50.5-0.50.40.40.4-0.4-0.40.40.40.50.50.2-0.9
Total zone transitions, hab. session 20.20.30.70.60.60.6-0.60.60.50.5-0.5-0.50.50.70.50.5-0.8-0.2
Total locomotion distance, hab. session 20.10.10.50.30.30.2-0.30.30.10.1-0.1-0.10.10.10.20.5-0.70.3
Locomotion velocity, hab. session 20.00.00.30.10.10.1-0.10.2-0.0-0.00.00.0-0.0-0.00.00.4-0.60.4
Novel to familiar place preference ratio1.61.83.4-1.4-1.4-1.41.4-1.4-1.2-1.21.21.2-1.2-1.4-1.4-1.41.80.1
Novelty place preference1.21.32.8-1.2-1.2-1.21.2-1.2-1.1-1.11.11.1-1.1-1.1-1.2-1.11.7-0.2
Time in novel zone, NPP test1.01.12.7-1.1-1.1-1.11.1-1.1-0.9-0.90.90.9-0.9-1.0-1.1-1.01.6-0.3
Total zone transitions, NPP test1.21.72.31.41.41.4-1.41.41.31.3-1.3-1.31.31.41.31.3-1.50.9
Total locomotion distance, NPP test1.52.12.91.51.51.4-1.51.41.41.4-1.4-1.41.41.31.41.7-1.71.1
Locomotion velocity, NPP test0.81.21.91.11.11.0-1.11.11.01.0-1.0-1.01.00.91.11.2-1.41.3
Intraocular pressure6.39.111.33.23.23.2-3.23.03.13.1-3.1-3.13.13.03.13.4-2.81.3
Delta distance traveled before/after self-admin0.10.11.0-0.1-0.1-0.10.0-0.1-0.2-0.20.20.2-0.2-0.10.00.0-0.61.0
Delta ambulatory time before/after self-admin0.10.10.80.20.20.2-0.20.20.10.1-0.1-0.10.10.10.30.1-0.40.9
Parametrial fat weight0.92.22.91.51.51.6-1.51.41.51.5-1.5-1.51.51.51.71.3-1.40.7
Pavlov. Cond. lever latency0.10.20.6-0.3-0.3-0.50.3-0.2-0.3-0.30.30.3-0.3-0.5-0.70.10.2-0.8
Pavlov. Cond. magazine entry latency0.10.10.60.20.20.2-0.20.00.10.1-0.1-0.10.10.20.10.2-0.50.8
Pavlov. Cond. change in total contacts0.00.00.3-0.1-0.2-0.00.1-0.2-0.1-0.10.10.1-0.10.00.0-0.50.30.1
Pavlov. Cond. index score0.00.10.4-0.1-0.10.00.1-0.1-0.1-0.10.10.1-0.10.00.2-0.50.30.7
Pavlov. Cond. latency score0.00.00.3-0.1-0.10.10.1-0.1-0.1-0.10.10.1-0.10.10.3-0.50.20.5
Pavlov. Cond. lever contacts0.50.51.00.70.70.9-0.70.60.70.7-0.7-0.70.70.91.00.2-0.50.9
Pavlov. Cond. magazine entry number0.00.00.5-0.1-0.0-0.10.1-0.1-0.1-0.10.10.1-0.1-0.1-0.10.10.1-0.7
Pavlov. Cond. intertrial magazine entries0.40.50.70.60.60.6-0.60.70.70.7-0.7-0.70.70.60.50.7-0.80.9
Pavlov. Cond. lever-magazine prob. diff.0.10.10.5-0.3-0.4-0.20.4-0.3-0.3-0.30.30.3-0.3-0.2-0.1-0.70.50.6
Pavlov. Cond. response bias0.20.21.30.40.40.5-0.40.40.40.4-0.4-0.40.40.50.50.2-0.51.1
Pavlov. Cond. lever latency0.10.10.6-0.3-0.3-0.40.3-0.4-0.3-0.30.30.3-0.3-0.3-0.4-0.20.4-0.8
Pavlov. Cond. magazine entry latency1.21.42.5-1.2-1.2-1.21.2-1.3-1.2-1.21.21.2-1.2-1.1-1.2-1.20.9-1.6
Pavlov. Cond. change in total contacts1.32.13.3-1.6-1.6-1.51.6-1.3-1.4-1.41.41.4-1.4-1.5-1.4-1.81.50.4
Pavlov. Cond. index score0.60.81.2-1.0-1.0-0.91.0-0.8-0.9-0.90.90.9-0.9-0.9-0.9-1.10.8-0.1
Pavlov. Cond. latency score0.50.71.0-0.9-0.9-0.90.9-0.8-0.8-0.80.80.8-0.8-0.8-0.8-1.00.8-0.2
Pavlov. Cond. lever contacts0.00.00.30.10.10.2-0.10.20.20.2-0.2-0.20.20.20.3-0.0-0.20.5
Pavlov. Cond. magazine entry number2.43.03.31.81.81.7-1.81.81.71.7-1.7-1.71.71.71.71.8-1.81.6
Pavlov. Cond. intertrial magazine entries5.68.49.03.03.03.0-3.02.92.92.9-2.9-2.92.93.03.03.0-2.92.1
Pavlov. Cond. lever-magazine prob. diff.0.81.11.6-1.1-1.2-1.11.1-1.0-1.0-1.01.01.0-1.0-1.1-1.0-1.31.0-0.3
Pavlov. Cond. response bias0.00.10.1-0.3-0.3-0.20.3-0.2-0.2-0.20.20.2-0.2-0.2-0.2-0.40.20.2
Time in closed arm before self-admin2.53.24.4-1.7-1.8-1.71.8-1.8-1.7-1.71.71.7-1.7-1.7-1.7-1.82.0-2.1
Time in closed arm after self-admin0.20.21.3-0.4-0.4-0.40.4-0.5-0.4-0.40.40.4-0.4-0.3-0.4-0.20.4-1.1
Time in open arm before self-admin0.00.00.10.20.20.2-0.20.30.10.1-0.1-0.10.10.20.10.0-0.10.1
Time in open arm after self-admin0.00.00.10.20.20.1-0.10.30.20.2-0.2-0.20.20.20.10.1-0.10.1
Bone: periosteal estimation13.027.429.7-5.4-5.4-5.35.4-5.4-5.5-5.55.55.5-5.5-5.2-5.2-5.24.8-3.7
Bone: periosteal perimeter10.918.720.6-4.5-4.5-4.44.5-4.5-4.5-4.54.54.5-4.5-4.3-4.3-4.43.7-2.4
Bone: post-yield work9.413.714.6-3.7-3.7-3.73.7-3.8-3.8-3.83.83.8-3.8-3.7-3.7-3.43.5-3.7
Progressive ratio test 1 active lever presses5.66.97.82.72.62.8-2.62.62.82.8-2.8-2.82.82.62.72.3-1.62.4
Progressive ratio test 1 breakpoint5.16.37.22.62.52.7-2.52.52.72.7-2.7-2.72.72.52.62.2-1.52.3
Progressive ratio test 1 inactive lever presses2.02.83.51.81.71.8-1.71.61.81.8-1.8-1.81.81.81.91.6-1.10.7
Progressive ratio test 2 active lever presses1.72.02.81.61.51.6-1.51.71.41.4-1.4-1.41.41.41.71.3-0.7-0.1
Progressive ratio test 2 breakpoint1.61.82.71.51.51.6-1.51.61.41.4-1.4-1.41.41.31.61.2-0.7-0.1
Progressive ratio test 2 inactive lever presses1.01.72.51.41.41.5-1.41.51.21.2-1.2-1.21.21.31.61.2-0.8-0.9
Incentive Sensitization - Responses0.60.98.3-0.4-0.4-0.30.4-0.4-0.8-0.80.80.8-0.8-0.6-0.1-0.50.6-2.9
Incentive Sensitization - Breakpoint0.50.76.5-0.3-0.3-0.20.3-0.3-0.7-0.70.70.7-0.7-0.5-0.1-0.40.5-2.5
Sum of active levers in priming session hrs 5-60.00.00.1-0.1-0.1-0.20.10.0-0.1-0.10.10.1-0.1-0.1-0.3-0.1-0.1-0.3
Progressive ratio0.20.30.70.50.50.6-0.60.40.40.4-0.4-0.40.40.40.70.5-0.70.8
Food seeking constrained by brief footshock0.91.11.31.01.01.1-1.01.01.11.1-1.1-1.11.11.11.20.7-0.81.1
Seeking ratio, punishment vs. effort0.00.00.10.10.10.1-0.10.20.30.3-0.3-0.30.30.2-0.0-0.00.10.0
Retroperitoneal fat weight0.31.21.51.11.11.2-1.11.11.11.1-1.1-1.11.11.21.21.1-1.20.6
Reaction time number correct1.12.22.7-1.4-1.4-1.51.4-1.5-1.6-1.61.61.6-1.6-1.6-1.5-1.01.0-1.6
Reaction time mean minus median4.711.712.23.43.43.4-3.43.43.53.5-3.5-3.53.53.43.33.2-3.53.4
Reaction time mean minus median AUC3.28.28.92.92.82.8-2.83.02.92.9-2.9-2.92.92.82.72.7-2.93.0
Reaction time num false alarms1.42.03.01.41.51.4-1.51.41.41.4-1.4-1.41.41.41.41.5-1.70.6
Reaction time num false alarms AUC2.03.15.01.81.81.7-1.81.81.71.7-1.7-1.71.71.61.71.8-2.21.4
Reaction time trials correct on left1.12.22.7-1.4-1.4-1.51.4-1.5-1.6-1.61.61.6-1.6-1.6-1.5-1.01.0-1.6
Reaction time trials on left0.91.72.3-1.2-1.2-1.31.2-1.4-1.5-1.51.51.5-1.5-1.4-1.3-0.80.8-1.5
Reaction time mean0.61.01.21.01.01.1-1.01.11.01.0-1.0-1.01.01.01.00.7-0.91.0
Reaction time mean AUC0.40.61.20.70.70.8-0.70.80.70.7-0.7-0.70.70.70.80.5-0.71.1
Median of all reaction times0.00.00.1-0.1-0.1-0.00.1-0.0-0.2-0.20.20.2-0.2-0.10.0-0.30.2-0.1
Reaction time omissions9.413.715.83.93.93.8-3.93.93.73.7-3.7-3.73.73.83.84.0-3.81.9
Reaction time false alarm rate2.63.64.41.91.91.9-1.91.91.91.9-1.9-1.91.91.91.91.7-2.11.6
Reaction time premature initiation rate5.37.39.42.82.82.9-2.82.72.82.8-2.8-2.82.83.03.12.4-2.01.3
Reaction time premature initiations1.83.34.61.91.92.0-1.91.81.81.8-1.8-1.81.82.02.11.8-1.40.6
Std. dev. reaction times4.88.89.53.03.03.0-3.03.13.03.0-3.0-3.03.03.03.02.8-3.02.4
Reaction time trials completed0.91.72.3-1.2-1.2-1.31.2-1.4-1.5-1.51.51.5-1.5-1.4-1.3-0.80.8-1.5
Reaction time trials AUC1.42.73.2-1.6-1.5-1.71.6-1.7-1.8-1.81.81.8-1.8-1.8-1.7-1.11.2-1.7
Run reversals in cocaine runway, females0.10.10.8-0.1-0.1-0.10.1-0.1-0.2-0.20.20.2-0.2-0.1-0.20.10.1-0.9
Run reversals in cocaine runway, males1.31.31.61.11.11.1-1.11.01.31.3-1.3-1.31.31.11.11.1-0.90.9
Latency to leave start box in cocaine runway0.00.00.10.20.20.2-0.20.10.20.2-0.2-0.20.20.20.20.2-0.2-0.1
Latency to leave start box in cocaine runway, F0.91.11.41.11.11.1-1.11.01.01.0-1.0-1.01.01.11.21.1-0.8-0.4
Latency to leave start box in cocaine runway, M1.51.41.8-1.3-1.3-1.31.3-1.3-1.2-1.21.21.2-1.2-1.3-1.3-1.31.0-0.0
Std. dev. time between licks in bursts0.81.01.71.11.11.2-1.11.01.11.1-1.1-1.11.11.01.30.9-0.70.0
Total sessions with >9 infusions2.22.74.11.61.61.8-1.61.51.61.6-1.6-1.61.61.72.01.2-1.12.0
Short access day 1 total inactive lever presses1.82.32.81.61.51.7-1.51.51.61.6-1.6-1.61.61.61.71.2-1.20.9
Short access day 10 total inactive lever presses0.10.20.60.40.40.3-0.40.50.50.5-0.5-0.50.50.50.20.5-0.3-0.8
Short access day 1 total infusions0.81.03.90.90.91.1-0.90.81.01.0-1.0-1.01.00.91.10.6-0.62.0
Short access day 10 total infusions1.72.13.31.41.41.6-1.41.21.51.5-1.5-1.51.51.51.70.9-1.01.8
Short access total infusions2.53.14.31.81.72.0-1.81.61.81.8-1.8-1.81.81.82.11.3-1.21.9
Short access day 1 locomotion0.30.31.60.50.40.6-0.40.40.60.6-0.6-0.60.60.50.60.20.11.2
Short access day 10 total locomotion0.20.40.50.60.60.6-0.60.50.70.7-0.7-0.70.70.60.60.6-0.0-0.5
Short access total locomotion0.91.01.31.11.01.1-1.11.01.11.1-1.1-1.11.11.11.10.9-0.30.0
One hour access (0.3 mA shock)0.10.20.40.40.40.5-0.40.30.40.4-0.4-0.40.40.40.60.0-0.10.6
Compulsive drug intake0.00.00.10.00.00.0-0.0-0.00.10.1-0.1-0.10.10.1-0.00.3-0.4-0.1
One hour access (shock baseline)0.00.00.20.00.00.2-0.0-0.0-0.1-0.10.10.1-0.1-0.00.3-0.40.3-0.4
Social response proportion0.20.20.40.40.40.4-0.40.50.40.4-0.4-0.40.40.40.50.2-0.30.6
Social responses7.39.410.63.13.13.2-3.13.23.23.2-3.2-3.23.23.23.32.9-2.71.9
Social time0.10.22.5-0.1-0.1-0.10.1-0.0-0.0-0.00.00.0-0.0-0.0-0.1-0.0-0.71.6
Soleus weight0.51.42.0-1.3-1.3-1.31.3-1.2-1.1-1.11.11.1-1.1-1.2-1.4-1.31.10.4
Bone: stiffness18.229.633.3-5.6-5.6-5.65.6-5.8-5.7-5.75.75.7-5.7-5.6-5.5-5.44.8-3.5
Tibialis anterior weight0.72.56.6-1.7-1.8-1.51.8-1.4-1.3-1.31.31.3-1.3-1.3-1.5-2.32.60.3
Time to tail flick, vehicle, before self-admin1.51.52.31.31.31.2-1.31.41.21.2-1.2-1.21.21.21.01.5-1.50.4
Time to tail flick, vehicle, after self-admin0.20.32.6-0.3-0.3-0.30.3-0.4-0.4-0.40.40.4-0.4-0.4-0.2-0.30.8-1.6
Time to tail flick, test, before self-admin0.20.30.70.50.50.4-0.50.50.30.3-0.3-0.30.30.60.30.7-0.6-0.9
Time to tail flick, test, after self-admin0.70.81.0-0.8-0.8-0.90.8-0.9-1.0-1.01.01.0-1.0-0.8-0.9-0.80.5-0.5
Delta time to tail flick, vehicle, before/after SA0.50.50.7-0.7-0.7-0.70.7-0.8-0.7-0.70.70.7-0.7-0.7-0.5-0.80.8-0.6
Delta time to tail flick, test, before/after SA0.30.30.8-0.5-0.5-0.50.5-0.6-0.4-0.40.40.4-0.4-0.6-0.4-0.60.40.9
Tibia length7.420.323.2-4.7-4.7-4.64.7-4.6-4.6-4.64.64.6-4.6-4.6-4.4-4.84.4-2.5
Ambulatory time before self-admin1.72.63.11.61.61.6-1.61.71.81.8-1.8-1.81.81.61.61.6-1.20.9
Ambulatory time after self-admin1.11.31.71.21.21.2-1.21.21.21.2-1.2-1.21.21.21.31.0-1.00.9
Bone: tissue strength1.01.01.7-1.0-1.0-1.21.0-1.0-1.0-1.01.01.0-1.0-1.1-1.3-0.80.8-0.4
Total heroin consumption1.21.45.3-1.0-1.0-1.01.0-0.9-1.0-1.01.01.0-1.0-1.0-1.0-1.11.7-2.3
Bone: trabecular number5.89.611.8-3.3-3.3-3.33.2-3.3-3.3-3.33.33.3-3.3-3.4-3.2-3.11.80.1
Bone: trabecular spacing2.22.93.61.81.81.9-1.81.71.81.8-1.8-1.81.81.91.91.6-0.7-1.2
Bone: trabecular thickness0.20.21.80.20.20.3-0.20.20.30.3-0.3-0.30.30.20.40.2-0.51.4
Bone: trabecular tissue density0.10.11.30.10.10.1-0.1-0.00.00.0-0.0-0.00.00.00.10.20.4-1.1
Water consumed over 24 hours0.10.10.2-0.3-0.3-0.30.3-0.4-0.4-0.40.40.4-0.4-0.4-0.4-0.20.0-0.0
Number of responses in last shaping day0.20.21.40.30.30.4-0.30.40.20.2-0.2-0.20.20.20.4-0.10.4-1.2