Klhl26

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	mRNA stability	Klhl26	0.07	0.04	1.1e-08	0.11	0.08	0.1	0.1	3.1e-10	3.3e-08	3.1e-09	1.3e-09
2	IL	gene expression	Klhl26	0.19	0.1	4.1e-04	0.1	0.12	0.13	0.06	1.9e-03	1.1e-03	4.9e-04	1.6e-02
3	Liver	gene expression	Klhl26	0.07	0.03	5.3e-12	0.07	0.09	0.09	0.08	1.4e-08	3.3e-10	9.8e-10	8.0e-09
4	Liver	mRNA stability	Klhl26	0.03	0.02	2.6e-05	0.01	0.04	0.03	0.03	8.1e-03	6.3e-05	3.7e-04	5.4e-04
5	RMTg	gene expression	Klhl26	0.14	0.08	1.1e-03	0.07	0.11	0.08	0.09	8.1e-03	9.4e-04	4.5e-03	2.9e-03
6	Adipose	mRNA stability	Klhl26	0.05	0.03	5.3e-05	0.04	0.04	0.02	0.04	1.6e-05	5.6e-05	2.0e-03	3.8e-05
7	NAcc	gene expression	Klhl26	0.06	0.04	1.2e-03	0.01	0.01	0.01	0	3.6e-02	1.8e-02	3.4e-02	6.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7
Bone: apparent density	1.0	1.8	6.6	0.7	-1.8	0.5	0.3	0.9	-0.9	-2.6
Area under the delay curve	0.1	0.1	0.5	-0.5	0.4	0.0	-0.0	0.2	0.0	-0.7
BMI with tail	1.6	5.4	7.1	2.4	-2.6	2.6	2.7	-2.4	2.3	0.3
BMI without tail	3.0	9.1	12.6	2.9	-3.4	3.5	3.5	-3.2	2.8	0.9
Body weight	3.9	16.9	28.6	4.6	-5.4	4.8	4.7	-3.6	3.0	-0.8
Weight adjusted by age	1.8	2.7	3.4	1.8	-1.8	1.7	1.8	-1.7	1.4	1.1
Bone surface	0.5	0.9	3.8	0.5	-1.4	0.4	0.3	0.5	-0.1	-1.9
Bone volume	0.8	1.5	4.1	1.0	-2.0	1.0	0.9	0.1	0.0	-1.9
Breakpoint value in progressive ratio session	0.2	0.2	0.4	-0.1	0.4	0.1	0.2	-0.5	0.7	0.6
Number of licking bursts	0.2	0.4	1.4	-0.3	0.3	-0.3	-0.4	0.6	-0.7	-1.2
Context. condit. distance diff. score	0.3	0.4	1.5	0.3	0.1	-0.5	-0.6	0.7	-1.2	-0.2
Locomotion velocity, session 1	0.4	0.4	1.1	-0.5	0.5	-0.2	-0.0	-0.5	1.1	1.0
Locomotion distance, session 1	1.2	1.5	2.3	-1.5	1.2	-1.5	-1.4	1.3	-0.6	-0.6
Locomotion velocity, session 2	1.7	1.9	3.1	0.7	-0.8	1.5	1.6	-1.8	1.7	1.2
Locomotion distance, session 2	1.7	2.4	4.3	-2.1	1.7	-1.8	-1.7	1.5	-0.8	-0.6
Locomotion velocity, session 3	0.7	0.7	1.7	-0.7	1.3	-0.8	-0.7	0.2	-0.4	1.3
Locomotion distance, session 3	0.9	1.0	2.0	-0.7	0.3	-1.1	-1.1	1.3	-1.4	-0.8
Stereotopy head waving bouts, day 3	1.6	1.9	3.2	-0.6	1.6	-1.4	-1.5	1.5	-1.8	-0.8
Stereotopy head waving duration, day 3	0.4	0.5	1.0	-0.2	1.0	-0.6	-0.7	0.7	-1.0	-0.3
Locomotion velocity, session 7	0.8	0.8	1.6	-1.1	1.3	-1.1	-1.0	0.5	-0.5	0.7
Locomotion distance, session 7	0.9	1.2	1.6	-1.2	1.2	-1.2	-1.2	1.1	-0.8	-0.6
Stereotopy head waving bouts, day 7	0.2	0.2	0.8	0.1	0.2	-0.3	-0.3	0.4	-0.9	-0.2
Stereotopy head waving duration, day 7	0.2	0.2	0.5	0.6	-0.1	0.4	0.4	-0.4	-0.2	0.7
Locomotion velocity, session 8	1.3	1.6	3.5	-1.2	1.9	-1.4	-1.2	0.4	-0.5	1.5
Locomotion distance, session 8	0.7	1.0	1.5	-1.0	0.8	-1.2	-1.2	1.1	-0.9	-0.5
Degree of sensitization distance	0.2	0.2	0.6	-0.5	0.8	-0.2	-0.2	-0.1	0.4	0.4
Degree of sensitization stereotypy	0.1	0.1	0.3	0.5	-0.6	0.2	0.2	0.1	-0.5	-0.2
Conditioned locomotion	0.2	0.3	1.1	0.3	-0.1	-0.3	-0.4	0.6	-0.3	-1.0
Cocaine response after cond. corrected	0.2	0.3	1.3	0.6	-0.0	-0.1	-0.3	0.4	-1.2	-0.3
Cocaine response after cond. not corrected	0.3	0.3	1.1	-0.1	0.7	-0.5	-0.6	0.4	-1.0	0.3
Cocaine response before conditioning	0.8	1.0	2.2	-1.5	1.4	-0.6	-0.4	-0.2	0.8	1.2
Saline control response	0.1	0.1	0.4	-0.6	0.1	-0.4	-0.4	0.3	-0.2	0.3
Bone: connectivity density	0.9	1.3	4.6	0.6	-1.9	0.6	0.4	0.5	-0.2	-2.2
Bone: cortical apparent density	0.2	0.2	0.8	-0.9	0.3	-0.0	0.1	-0.2	0.8	0.4
Bone: cortical area	3.7	5.6	10.6	3.0	-3.3	2.8	2.7	-1.9	1.1	-0.3
Bone: cortical porosity	0.1	0.1	0.3	-0.3	0.2	-0.1	-0.0	-0.2	0.6	-0.0
Bone: cortical porosity	0.1	0.1	0.3	-0.2	0.1	-0.2	-0.1	0.0	0.5	-0.3
Bone: cortical thickness	1.9	3.1	7.3	2.5	-2.7	1.9	1.8	-0.9	0.1	-1.0
Bone: cortical thickness	2.0	2.4	6.0	1.8	-1.6	0.3	0.0	1.0	-1.9	-2.4
Bone: cortical tissue density	0.2	0.3	0.9	-1.0	0.4	-0.1	0.0	-0.2	0.7	0.4
Condit. Reinf. active minus inactive responses	0.7	0.8	3.2	0.6	-0.8	0.1	-0.1	0.7	-1.0	-1.8
Condit. Reinf. active-inactive response ratio	1.2	1.2	4.7	0.5	-0.8	-0.1	-0.3	1.1	-1.3	-2.2
Condit. Reinf. active responses	0.5	0.6	2.0	0.8	-0.9	0.4	0.2	0.3	-0.6	-1.4
Condit. Reinf. inactive responses	0.6	0.7	1.0	0.7	-0.8	0.9	0.9	-1.0	0.9	0.6
Incentive salience index mean	0.4	0.5	2.2	0.6	-0.7	0.4	0.3	0.1	-0.2	-1.5
Condit. Reinf. lever presses	0.3	0.4	0.9	0.4	-0.6	0.7	0.7	-0.4	0.5	-1.0
Condit. Reinf. active minus inactive responses	0.2	0.2	0.3	-0.6	0.5	-0.6	-0.5	0.3	0.1	0.4
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.4	0.6	-0.6	0.5	0.5	-0.4	0.3	0.2
Condit. Reinf. active responses	0.8	1.1	2.1	-1.4	1.4	-1.1	-1.0	0.4	0.3	1.1
Condit. Reinf. inactive responses	1.7	2.2	4.4	-1.9	2.1	-1.4	-1.2	0.3	0.5	1.8
Condit. Reinf. lever presses	0.7	1.0	2.4	-0.0	0.3	0.5	0.6	-1.1	1.6	1.5
Condit. Reinf. lever reinforcers received	0.4	0.5	1.5	-0.8	0.9	-0.5	-0.3	-0.2	0.8	1.2
Conditioned reinforcement - actives	1.3	2.2	4.3	1.8	-2.1	1.6	1.6	-1.3	0.8	0.3
Conditioned reinforcement - inactives	5.1	7.5	14.2	3.4	-3.8	3.2	3.0	-2.3	1.3	0.2
Conditioned locomotion	1.5	2.0	3.9	2.0	-1.9	1.5	1.5	-1.2	0.6	0.4
Patch foraging indifference point 0 sec	1.9	3.5	5.3	2.3	-1.6	2.2	2.2	-2.1	1.5	0.5
Patch foraging indifference point AUC	0.4	0.6	2.0	-0.5	0.8	0.3	0.4	-0.7	1.4	0.5
Delay disc. indifference point, 0s delay	2.0	2.2	5.0	-2.0	2.2	-1.5	-1.4	1.1	-0.8	-0.4
Delay disc. indifference point, 16s delay	0.3	0.4	1.3	-0.9	1.1	-0.4	-0.4	0.3	0.2	-0.3
Delay disc. indifference point, 2s delay	0.9	1.0	1.8	-1.3	1.2	-0.9	-0.9	0.9	-0.8	-1.0
Delay disc. indifference point, 24s delay	0.4	0.4	0.9	0.1	-0.2	0.8	0.7	-0.8	0.9	0.3
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	-0.5	0.3	-0.0	-0.0	0.1	0.1	-0.3
Delay disc. indifference point, 8s delay	0.2	0.2	0.5	0.2	-0.1	0.7	0.6	-0.5	0.5	-0.3
Indifference point function ln k	0.6	1.0	3.2	1.5	-1.8	0.8	0.6	-0.2	-0.4	-0.8
Indifference point function log k	0.6	1.0	3.2	1.5	-1.8	0.8	0.6	-0.2	-0.4	-0.8
Patch foraging total patch changes 0 sec	2.9	5.4	8.0	2.8	-2.1	2.8	2.8	-2.6	1.8	0.5
Patch foraging total patch changes 12 sec	0.9	1.1	1.9	0.9	-0.2	1.1	1.2	-1.4	1.4	0.9
Patch foraging total patch changes 18 sec	0.3	0.4	0.8	-0.0	0.8	0.1	0.2	-0.6	0.9	0.9
Patch foraging total patch changes 24 sec	0.2	0.3	1.0	1.0	-0.3	0.5	0.5	-0.5	0.4	-0.1
Patch foraging total patch changes 6 sec	1.6	2.4	4.0	1.5	-0.6	1.7	1.8	-2.0	1.8	1.2
Patch foraging time to switch 0 sec	0.8	1.6	4.1	-2.0	1.7	-1.3	-1.2	0.8	-0.4	0.7
Patch foraging water rate 0 sec	0.7	1.5	2.4	1.6	-1.3	1.5	1.4	-1.1	1.0	-0.6
Patch foraging water rate 12 sec	0.4	0.9	2.1	1.2	-1.5	0.8	0.7	-0.3	0.2	-1.1
Patch foraging water rate 18 sec	0.3	0.4	2.6	-0.0	-0.4	-0.1	-0.2	0.5	0.1	-1.6
Patch foraging water rate 24 sec	0.6	0.8	3.3	0.5	-1.3	0.5	0.4	0.2	0.4	-1.8
Patch foraging water rate 6 sec	1.3	1.9	4.0	2.0	-2.0	1.4	1.3	-0.9	0.6	-0.6
Seeking ratio, delayed vs. immediate footshock	0.4	0.5	1.2	-1.1	0.8	-0.7	-0.6	0.2	-0.2	0.8
Distance traveled before self-admin	0.9	1.2	2.0	0.7	-0.8	1.2	1.2	-1.4	1.0	1.2
Distance traveled after self-admin	1.1	1.4	2.0	1.1	-1.0	1.2	1.3	-1.4	1.1	1.0
Extensor digitorum longus weight	0.2	0.8	1.2	1.0	-0.6	1.0	1.0	-1.1	0.9	0.7
Bone: elastic displacement	0.3	0.4	0.7	-0.8	0.3	-0.6	-0.6	0.7	-0.6	-0.3
Bone: elastic work	1.0	1.3	2.5	1.3	-1.6	1.4	1.3	-0.9	0.6	-0.1
Bone: endosteal estimation	0.3	0.6	1.5	0.5	-0.6	0.9	0.9	-0.9	1.2	-0.0
Bone: endosteal perimeter	0.9	1.9	3.1	1.8	-1.6	1.6	1.5	-1.3	1.0	0.3
Epididymis fat weight	1.0	3.5	5.3	1.0	-2.2	2.2	2.3	-1.9	2.2	0.2
Delta time in closed arm before/after self-admin	0.2	0.2	0.6	0.3	0.0	0.5	0.4	-0.3	0.7	-0.4
Delta time in open arm before/after self-admin	0.6	0.6	1.8	-1.3	0.9	-0.8	-0.7	0.5	-0.1	0.2
Diff in mean of infusions in LGA sessions	2.5	3.0	5.0	1.0	-0.5	1.6	1.8	-2.2	2.1	2.2
Delay discount exponential model param	0.1	0.1	0.5	0.2	-0.1	-0.2	-0.1	-0.0	-0.0	0.7
Extinction: sum of active levers before priming	0.6	0.6	2.2	-1.5	0.8	-0.6	-0.5	0.6	-0.2	-0.6
Active lever presses in extinction session 6	0.2	0.2	0.5	-0.6	0.6	-0.3	-0.3	-0.0	0.2	0.7
Bone: final force	5.3	8.4	12.7	3.6	-3.4	3.4	3.3	-2.5	2.3	-0.6
Bone: final moment	5.0	8.0	12.5	3.5	-3.4	3.4	3.2	-2.4	2.1	-0.6
Food consumed during 24 hour testing period	0.5	0.7	0.8	-0.9	0.7	-0.9	-0.9	0.9	-0.4	-0.9
Glucose	1.6	2.5	4.3	1.3	-1.0	1.7	1.8	-1.9	2.1	0.9
Heart weight	0.8	1.2	3.4	1.8	-1.8	0.6	0.4	0.2	-0.9	-0.9
Delay discount hyperbolic model param	0.1	0.1	0.5	0.2	-0.2	-0.1	-0.1	-0.1	0.1	0.7
Intermittent access intake day 1-15 change	0.1	0.2	0.8	0.5	-0.9	0.1	0.1	0.3	-0.5	-0.5
Intermittent access intake escalation	0.2	0.3	0.6	0.2	-0.7	-0.1	-0.2	0.6	-0.8	-0.8
Intermittent access intake escalation 2	0.4	0.5	1.4	0.4	-1.2	0.8	0.8	-0.5	0.4	-0.1
Intermitt. access day 1 inactive lever presses	0.1	0.4	1.2	0.6	-0.7	0.4	0.4	-0.5	0.2	1.1
Intermitt. access day 15 inactive lever presses	0.1	0.2	0.3	0.6	-0.3	-0.3	-0.3	0.2	-0.4	0.5
Intermitt. access escalation Index	0.5	0.6	0.9	-0.8	0.5	-0.8	-0.8	0.9	-0.7	-0.9
Intermittent access day 1 total infusions	1.0	1.6	3.2	1.8	-1.0	1.3	1.3	-1.4	0.9	0.9
Intermittent access day 15 total infusions	0.3	0.5	1.6	1.0	-1.3	0.5	0.4	-0.1	-0.3	-0.5
Intermittent access terminal intake (last 3 days)	0.4	0.5	1.4	1.0	-1.2	0.7	0.6	-0.3	0.0	-0.6
Intermittent access total infusions	1.3	1.5	2.7	1.6	-1.5	1.4	1.4	-1.1	0.6	0.2
Intermittent access day 1 locomotion	2.3	2.9	4.3	2.1	-1.7	1.9	1.9	-1.9	1.4	0.9
Intermittent access day 15 total locomotion	0.2	0.4	0.8	0.9	-0.9	0.6	0.5	-0.3	0.1	-0.5
Intermittent access total locomotion	2.0	2.4	3.7	1.9	-1.8	1.8	1.8	-1.6	1.0	0.5
Intermittent access standard deviation	0.2	0.4	0.9	0.7	-0.9	0.7	0.7	-0.6	0.4	0.2
Left kidney weight	0.5	2.6	4.0	1.2	-1.1	1.7	1.8	-2.0	1.9	1.3
Right kidney weight	1.7	7.7	13.0	1.8	-2.2	2.9	3.2	-3.2	3.6	1.8
Cocaine induced anxiety	1.7	2.5	4.6	1.9	-0.7	1.4	1.5	-1.9	1.0	2.1
Post-drug Anxiety	0.3	0.4	1.6	0.4	0.2	0.2	0.3	-0.7	0.3	1.3
Baseline Anxiety	2.7	3.2	6.4	-2.5	1.5	-1.8	-1.8	1.9	-1.0	-1.4
Tail length	0.8	2.9	4.5	1.4	-2.0	2.1	2.1	-1.7	1.6	0.3
Length with tail	1.4	6.0	9.5	2.5	-3.1	3.0	3.0	-2.2	1.9	-0.3
Length without tail	0.8	2.6	5.5	2.2	-2.3	1.7	1.6	-0.7	0.1	-1.3
Times rat made contact with spout	0.4	0.4	1.6	-0.6	0.4	-0.4	-0.4	0.6	0.3	-1.3
Lifetime Intake	2.1	2.5	4.9	2.2	-2.0	1.8	1.7	-1.4	0.7	0.3
Liver weight, left	0.4	0.6	2.0	-1.4	0.9	-0.8	-0.7	0.6	-0.3	0.1
Liver weight, right	1.6	2.8	4.4	0.8	-1.5	1.9	2.1	-2.0	2.1	0.8
Locomotor activity	0.3	0.4	1.7	-0.9	-0.0	-0.1	-0.1	0.5	0.1	-1.3
Locomotor testing distance	0.5	0.9	2.2	-1.1	0.1	-0.7	-0.8	1.2	-0.7	-1.5
Locomotor testing rearing	0.2	0.5	1.5	-1.2	0.4	-0.5	-0.5	0.6	-0.2	-0.7
Locomotion in novel chamber	0.2	0.2	0.8	-0.3	-0.4	0.4	0.4	-0.0	0.4	-0.9
Locomotion in novel chamber post-restriction	1.1	1.9	8.8	-0.3	-0.9	-0.2	-0.4	1.3	-1.3	-3.0
Fecal boli incidents, locomotor time 1	0.0	0.1	0.3	-0.4	0.1	-0.1	-0.0	0.2	0.1	-0.5
Change in fecal boli incidents, locomotor task	0.4	0.4	1.4	-0.6	1.2	-0.4	-0.4	-0.1	0.2	0.8
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.6	0.3	0.1	0.3	0.4	-0.7	0.7	0.8
Bouts of movement, locomotor time 1	0.2	0.2	0.9	-1.0	0.7	-0.3	-0.2	-0.0	0.1	0.0
Total resting periods, locomotor time 1	0.4	0.4	1.4	-1.2	0.9	-0.6	-0.5	0.3	-0.0	-0.2
Rest time, locomotor task time 1	0.0	0.0	0.1	0.0	0.2	-0.1	-0.1	0.0	0.1	-0.1
Distance moved, locomotor task time 1	0.1	0.1	0.5	-0.2	0.2	-0.1	-0.0	-0.2	0.1	0.7
Vertical activity count, locomotor time 1	0.1	0.2	1.0	-1.0	-0.1	-0.1	0.0	-0.0	0.2	0.2
Time >=10cm from walls, locomotor time 2	0.8	1.2	2.0	-0.5	0.8	-1.3	-1.4	1.4	-1.3	-0.5
Bouts of movement, locomotor time 2	0.1	0.2	0.5	-0.4	0.7	-0.5	-0.5	0.3	-0.5	0.2
Total resting periods, locomotor time 2	0.1	0.1	0.4	-0.1	0.6	-0.3	-0.3	0.1	-0.4	0.3
Rest time, locomotor task time 2	0.3	0.4	0.7	0.3	-0.1	0.8	0.8	-0.8	0.7	0.2
Distance moved, locomotor task time 2	0.2	0.2	0.6	-0.1	-0.1	-0.6	-0.6	0.5	-0.8	0.4
Vertical activity count, locomotor time 2	0.4	0.6	2.3	-0.2	-0.1	-0.7	-0.7	0.9	-1.5	-0.1
Light reinforcement 1	0.2	0.4	1.9	0.0	0.1	0.5	0.6	-0.7	1.4	0.3
Light reinforcement 2	0.5	0.8	1.4	0.3	0.3	0.9	0.9	-1.2	1.1	1.0
Bone: marrow area	0.2	0.5	1.3	0.4	-0.5	0.8	0.8	-0.8	1.1	-0.2
Bone: maximum diameter	1.6	3.0	6.4	2.5	-2.3	2.0	1.8	-1.3	0.3	-0.2
Bone: maximum force	4.4	7.9	11.8	3.3	-3.4	3.3	3.2	-2.3	2.2	-0.8
Bone: maximum moment	3.9	6.9	10.7	3.2	-3.3	3.1	3.0	-2.1	2.0	-0.8
Mean time between licks in bursts	1.4	3.4	4.8	1.7	-2.0	2.2	2.2	-1.9	1.9	0.3
Mean num. licks in bursts	0.0	0.1	0.1	0.0	-0.3	-0.0	-0.0	0.2	0.3	-0.3
Cd content in liver	1.7	1.9	5.8	1.5	-1.8	0.8	0.5	0.5	-0.9	-2.4
Co content in liver	0.0	0.0	0.1	-0.0	0.3	-0.1	-0.2	0.2	-0.4	-0.1
Cu content in liver	2.0	2.3	3.2	-1.2	1.1	-1.7	-1.8	1.8	-1.7	-1.2
Fe content in liver	0.7	0.8	2.0	-1.4	1.3	-0.9	-0.9	0.6	-0.3	0.3
K content in liver	1.6	1.6	2.4	-1.3	1.5	-1.5	-1.5	1.2	-1.1	-0.1
Mg content in liver	0.2	0.2	0.5	-0.0	0.2	-0.5	-0.5	0.4	-0.7	0.0
Mn content in liver	0.1	0.1	0.4	0.4	-0.4	-0.0	-0.0	-0.1	-0.5	0.6
Na content in liver	1.8	1.9	4.4	-2.1	1.6	-1.6	-1.5	1.1	-0.7	0.1
Rb content in liver	1.0	1.2	3.7	1.9	-1.4	0.8	0.6	-0.0	-1.0	-0.8
Se content in liver	0.4	0.5	0.9	-0.5	0.6	-0.9	-0.8	0.7	-1.0	0.2
Sr content in liver	0.2	0.2	0.6	-0.8	0.2	-0.0	0.1	-0.2	0.8	0.5
Zn content in liver	0.2	0.2	0.7	-0.4	0.3	-0.1	-0.0	-0.3	0.7	0.9
Bone: minimum diameter	2.0	3.7	5.2	1.6	-2.1	2.2	2.3	-1.9	2.1	0.2
Time in familiar zone, hab. session 1	0.6	0.6	2.0	0.2	-0.7	0.7	0.8	-0.8	1.4	0.3
Time in novel zone, hab. session 1	0.7	0.7	1.6	0.1	-0.0	-0.4	-0.6	1.0	-1.2	-1.3
Total zone transitions, hab. session 1	0.2	0.3	1.1	-1.0	0.5	-0.5	-0.5	0.4	0.2	-0.5
Total locomotion distance, hab. session 1	1.0	1.4	3.3	-1.8	0.9	-1.1	-1.1	1.2	-0.2	-1.3
Locomotion velocity, hab. session 1	0.7	1.0	3.1	-1.8	1.0	-1.0	-0.9	0.8	0.2	-0.7
Time in familiar zone, hab. session 2	0.3	0.3	0.5	0.4	-0.6	0.4	0.5	-0.6	0.7	0.6
Time in novel zone, hab. session 2	0.2	0.2	0.5	-0.2	0.2	-0.2	-0.3	0.5	-0.5	-0.7
Total zone transitions, hab. session 2	0.1	0.1	0.3	-0.1	0.3	-0.5	-0.5	0.4	-0.5	-0.1
Total locomotion distance, hab. session 2	0.6	0.8	1.5	-0.5	0.1	-0.9	-1.0	1.2	-1.1	-1.1
Locomotion velocity, hab. session 2	0.6	0.8	1.3	-0.7	0.3	-1.0	-1.0	1.1	-0.9	-1.0
Novel to familiar place preference ratio	0.2	0.2	0.4	-0.0	-0.4	0.6	0.6	-0.3	0.6	-0.3
Novelty place preference	0.1	0.1	0.2	-0.1	-0.2	0.4	0.4	-0.2	0.5	-0.3
Time in novel zone, NPP test	0.1	0.1	0.3	-0.4	0.1	0.2	0.1	0.0	0.5	-0.4
Total zone transitions, NPP test	0.8	1.2	1.5	-0.9	0.9	-1.2	-1.2	1.2	-0.8	-1.2
Total locomotion distance, NPP test	1.9	2.6	3.8	-1.4	1.0	-1.7	-1.8	1.9	-1.2	-1.9
Locomotion velocity, NPP test	1.5	2.1	2.8	-1.4	1.1	-1.6	-1.6	1.7	-1.1	-1.5
Intraocular pressure	0.6	0.8	1.7	1.3	-1.2	1.1	1.0	-0.6	-0.4	0.0
Delta distance traveled before/after self-admin	0.5	0.6	0.9	0.3	-0.7	0.9	0.9	-0.9	0.8	0.4
Delta ambulatory time before/after self-admin	0.1	0.1	0.1	0.1	-0.2	0.3	0.3	-0.4	0.1	0.3
Parametrial fat weight	3.9	9.1	12.1	2.8	-2.9	3.5	3.5	-3.3	3.1	1.4
Pavlov. Cond. lever latency	0.1	0.1	0.6	0.4	-0.3	0.0	-0.0	-0.1	-0.1	0.8
Pavlov. Cond. magazine entry latency	0.2	0.3	0.5	0.3	-0.4	0.6	0.6	-0.4	0.7	-0.5
Pavlov. Cond. change in total contacts	0.5	0.5	1.0	0.7	-0.5	0.9	0.8	-0.5	0.7	-1.0
Pavlov. Cond. index score	0.1	0.1	0.4	-0.4	0.3	0.1	0.2	-0.1	0.5	-0.6
Pavlov. Cond. latency score	0.1	0.2	0.4	-0.6	0.6	-0.1	-0.0	0.1	0.4	-0.6
Pavlov. Cond. lever contacts	0.1	0.1	0.4	-0.3	0.2	0.3	0.4	-0.3	0.6	-0.4
Pavlov. Cond. magazine entry number	0.3	0.4	1.0	-0.4	0.5	-0.7	-0.8	0.7	-1.0	0.2
Pavlov. Cond. intertrial magazine entries	1.9	2.3	6.6	0.1	-0.4	-0.9	-1.2	1.8	-2.6	-1.9
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.3	-0.3	0.2	0.1	0.2	-0.2	0.5	-0.4
Pavlov. Cond. response bias	0.2	0.2	0.6	0.2	-0.4	0.5	0.5	-0.3	0.6	-0.7
Pavlov. Cond. lever latency	1.4	1.9	3.3	-0.4	-0.0	-1.2	-1.4	1.8	-1.8	-1.8
Pavlov. Cond. magazine entry latency	0.7	0.8	1.4	0.5	-0.0	0.9	1.0	-1.2	1.0	1.1
Pavlov. Cond. change in total contacts	0.8	1.3	2.3	0.5	0.1	1.0	1.1	-1.5	1.4	1.5
Pavlov. Cond. index score	1.4	1.9	3.3	0.7	-0.1	1.3	1.5	-1.8	1.6	1.7
Pavlov. Cond. latency score	0.9	1.2	2.4	0.4	0.2	0.9	1.1	-1.4	1.3	1.5
Pavlov. Cond. lever contacts	1.1	1.5	3.3	0.4	0.2	1.0	1.1	-1.6	1.6	1.8
Pavlov. Cond. magazine entry number	1.8	2.3	3.9	-0.9	0.5	-1.6	-1.8	2.0	-1.8	-1.5
Pavlov. Cond. intertrial magazine entries	0.4	0.6	1.0	-0.7	0.2	-1.0	-1.0	1.0	-0.7	-0.8
Pavlov. Cond. lever-magazine prob. diff.	1.5	2.0	3.4	0.8	-0.2	1.4	1.5	-1.8	1.6	1.6
Pavlov. Cond. response bias	1.6	2.2	3.8	0.7	-0.2	1.4	1.5	-1.9	1.8	1.9
Time in closed arm before self-admin	5.6	7.2	9.4	3.0	-2.5	2.7	2.7	-3.1	1.7	2.9
Time in closed arm after self-admin	4.4	4.6	8.0	2.8	-2.2	2.4	2.3	-2.3	1.2	1.5
Time in open arm before self-admin	1.1	1.2	1.9	-1.4	1.0	-1.1	-1.1	1.2	-0.7	-1.2
Time in open arm after self-admin	2.7	2.9	4.2	-2.1	1.4	-1.9	-1.8	2.0	-1.3	-1.4
Bone: periosteal estimation	1.5	3.1	5.2	2.0	-2.3	2.1	2.0	-1.5	1.3	-0.3
Bone: periosteal perimeter	3.1	5.4	10.0	3.2	-3.0	2.7	2.5	-2.0	1.0	0.2
Bone: post-yield work	0.2	0.3	1.7	-0.1	-0.0	-0.3	-0.4	0.6	-0.2	-1.3
Progressive ratio test 1 active lever presses	2.6	3.2	6.2	2.5	-1.8	1.9	1.9	-1.9	1.2	0.8
Progressive ratio test 1 breakpoint	2.3	2.9	5.8	2.4	-1.7	1.8	1.8	-1.8	1.1	0.7
Progressive ratio test 1 inactive lever presses	1.5	2.1	3.3	1.6	-1.8	1.4	1.4	-1.5	0.9	1.4
Progressive ratio test 2 active lever presses	0.9	1.1	1.9	1.4	-1.3	1.2	1.2	-1.0	0.5	0.3
Progressive ratio test 2 breakpoint	0.7	0.8	1.4	1.2	-1.1	1.0	1.0	-0.9	0.4	0.2
Progressive ratio test 2 inactive lever presses	0.9	1.4	3.8	2.0	-1.6	1.2	1.0	-0.8	0.1	-0.2
Incentive Sensitization - Responses	0.1	0.1	0.2	0.3	-0.4	0.3	0.2	-0.1	0.1	-0.5
Incentive Sensitization - Breakpoint	0.0	0.1	0.3	0.0	-0.2	0.1	0.1	0.1	0.0	-0.5
Sum of active levers in priming session hrs 5-6	5.6	5.2	7.8	-2.3	1.7	-2.3	-2.4	2.8	-2.0	-2.3
Progressive ratio	0.1	0.1	0.3	-0.2	0.2	-0.3	-0.4	0.5	-0.4	-0.5
Food seeking constrained by brief footshock	2.2	2.7	6.4	-0.2	0.0	-1.1	-1.3	2.1	-2.3	-2.5
Seeking ratio, punishment vs. effort	0.7	1.0	2.5	-0.5	0.1	-0.7	-0.8	1.2	-1.1	-1.6
Retroperitoneal fat weight	2.4	10.4	17.2	3.5	-4.2	3.8	3.7	-3.0	2.3	-0.0
Reaction time number correct	0.1	0.2	0.8	-0.6	-0.3	-0.2	-0.1	0.1	0.9	-0.1
Reaction time mean minus median	0.1	0.2	0.7	-0.2	0.6	0.1	0.1	-0.5	0.8	0.5
Reaction time mean minus median AUC	0.1	0.2	0.5	0.4	0.3	0.2	0.2	-0.6	0.7	0.7
Reaction time num false alarms	0.4	0.6	1.2	1.1	-0.5	0.8	0.8	-0.9	0.3	0.8
Reaction time num false alarms AUC	0.2	0.3	0.6	0.8	-0.1	0.6	0.6	-0.6	-0.0	0.7
Reaction time trials correct on left	0.1	0.2	0.8	-0.6	-0.3	-0.2	-0.1	0.1	0.9	-0.1
Reaction time trials on left	0.1	0.2	1.0	-0.6	-0.4	-0.1	0.0	-0.0	1.0	-0.1
Reaction time mean	1.1	1.7	2.5	1.1	-0.6	1.3	1.4	-1.6	1.5	1.4
Reaction time mean AUC	0.8	1.4	2.8	0.6	0.0	0.9	1.0	-1.4	1.6	1.7
Median of all reaction times	1.1	1.5	2.1	1.2	-0.8	1.3	1.3	-1.5	1.2	1.3
Reaction time omissions	1.9	2.8	5.3	1.0	-0.6	1.7	1.8	-2.1	2.3	1.5
Reaction time false alarm rate	0.3	0.4	1.3	1.2	-0.3	0.8	0.6	-0.5	-0.5	0.1
Reaction time premature initiation rate	0.4	0.5	1.3	-0.3	0.6	-0.8	-0.8	0.8	-0.5	-1.1
Reaction time premature initiations	0.1	0.2	0.5	-0.4	0.2	-0.5	-0.4	0.4	0.3	-0.7
Std. dev. reaction times	0.6	1.1	2.2	0.5	-0.2	1.0	1.1	-1.3	1.5	1.0
Reaction time trials completed	0.1	0.2	1.0	-0.6	-0.4	-0.1	0.0	-0.0	1.0	-0.1
Reaction time trials AUC	0.1	0.2	1.1	-0.4	-0.6	0.1	0.2	-0.2	1.1	-0.1
Run reversals in cocaine runway, females	2.9	2.9	4.6	2.1	-2.1	2.0	1.9	-1.6	1.0	0.2
Run reversals in cocaine runway, males	1.0	1.0	1.8	-1.1	1.3	-1.2	-1.1	0.7	-0.6	0.2
Latency to leave start box in cocaine runway	0.2	0.3	1.0	0.4	-0.6	0.4	0.4	-0.3	1.0	-0.2
Latency to leave start box in cocaine runway, F	0.5	0.5	1.1	0.7	-1.0	0.7	0.6	-0.4	0.9	-0.5
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	-0.2	0.5	-0.3	-0.3	0.0	0.1	0.4
Std. dev. time between licks in bursts	1.6	2.2	3.1	1.5	-1.8	1.8	1.7	-1.2	1.5	-0.6
Total sessions with >9 infusions	3.8	4.7	9.3	3.0	-2.6	2.3	2.2	-2.0	1.2	0.8
Short access day 1 total inactive lever presses	1.4	1.9	4.8	2.1	-2.2	1.4	1.1	-0.7	0.3	-0.3
Short access day 10 total inactive lever presses	0.4	1.0	4.6	-0.3	1.1	-0.6	-0.5	-0.4	0.3	2.1
Short access day 1 total infusions	2.9	3.8	8.1	2.4	-2.9	2.2	2.1	-1.5	0.9	-0.4
Short access day 10 total infusions	1.1	1.3	3.5	1.8	-1.9	1.1	0.9	-0.5	0.2	-0.7
Short access total infusions	2.2	2.8	5.3	2.3	-2.2	1.9	1.7	-1.4	1.0	0.0
Short access day 1 locomotion	5.1	6.3	11.2	3.3	-3.4	2.8	2.7	-2.1	1.3	0.6
Short access day 10 total locomotion	1.0	1.9	5.1	2.0	-2.3	1.3	1.2	-0.7	0.4	-0.4
Short access total locomotion	2.4	2.9	6.6	2.6	-2.5	1.8	1.7	-1.2	0.5	-0.2
One hour access (0.3 mA shock)	0.6	0.7	2.0	0.9	-0.9	0.6	0.3	0.3	-0.9	-1.4
Compulsive drug intake	1.2	1.4	1.6	-1.3	1.2	-1.2	-1.3	1.2	-1.2	-0.8
One hour access (shock baseline)	1.5	2.3	4.5	2.1	-2.0	1.8	1.7	-1.3	0.4	0.2
Social response proportion	1.6	1.8	4.2	1.6	-1.8	0.9	0.7	0.3	-1.0	-2.1
Social responses	1.0	1.3	5.2	-0.1	-0.7	-0.1	-0.3	1.1	-1.3	-2.3
Social time	0.3	0.4	1.5	-0.0	0.3	-0.4	-0.5	0.8	-1.2	-0.6
Soleus weight	1.2	3.4	5.0	1.8	-1.6	2.2	2.2	-2.0	2.0	0.2
Bone: stiffness	3.5	5.7	8.9	3.0	-2.7	2.7	2.7	-2.2	2.2	-0.1
Tibialis anterior weight	0.1	0.2	0.6	0.0	-0.5	0.4	0.5	-0.3	0.8	-0.4
Time to tail flick, vehicle, before self-admin	0.2	0.2	1.1	1.0	-0.4	0.1	0.0	0.1	0.2	-0.6
Time to tail flick, vehicle, after self-admin	0.6	0.8	3.3	0.2	-0.3	0.4	0.6	-1.0	1.0	1.8
Time to tail flick, test, before self-admin	1.1	1.1	2.8	1.7	-1.3	1.2	1.0	-0.8	-0.2	0.3
Time to tail flick, test, after self-admin	0.6	0.6	1.0	-0.6	0.7	-0.8	-0.9	1.0	-0.6	-0.6
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	1.3	-0.5	0.2	-0.3	-0.1	-0.2	0.2	1.2
Delta time to tail flick, test, before/after SA	0.9	1.0	1.7	-1.3	0.7	-1.0	-1.0	1.1	-0.3	-1.1
Tibia length	0.4	1.0	2.2	1.5	-1.3	1.1	1.0	-0.6	0.3	-0.6
Ambulatory time before self-admin	1.5	2.3	3.9	0.8	-1.0	1.6	1.7	-2.0	1.5	1.7
Ambulatory time after self-admin	2.1	2.4	3.8	1.2	-1.3	1.7	1.8	-1.9	1.5	1.3
Bone: tissue strength	1.1	1.2	3.3	0.1	0.0	0.6	0.8	-1.2	1.8	1.5
Total heroin consumption	0.4	0.5	0.9	-0.4	0.4	0.6	0.7	-1.0	0.9	0.8
Bone: trabecular number	1.0	1.6	4.5	0.8	-2.1	1.0	0.8	0.2	-0.0	-2.1
Bone: trabecular spacing	0.2	0.3	1.2	-0.4	0.8	-0.1	-0.1	-0.4	0.1	1.1
Bone: trabecular thickness	0.8	1.0	4.0	0.7	-1.3	0.4	0.3	0.5	-0.4	-2.0
Bone: trabecular tissue density	0.2	0.3	0.9	-1.0	0.9	-0.5	-0.3	-0.0	0.2	0.3
Water consumed over 24 hours	0.3	0.4	2.6	-0.1	-0.1	-0.1	-0.1	0.5	0.0	-1.6
Number of responses in last shaping day	0.7	0.8	3.7	0.6	-0.9	0.3	0.1	0.5	-0.7	-1.9