Hub : Genes

Klhl18

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Klhl18 0.06 0.05 1.9e-05 0.05 0.05 0.05 0.04 3.1e-05 3.0e-05 1.8e-05 4.7e-05
2 Eye mRNA stability Klhl18 0.42 0.27 7.1e-04 0.09 0.15 0.21 0.13 1.9e-02 3.0e-03 4.0e-04 5.5e-03
3 Eye alternative TSS XM_006244007.3 0.53 0.24 1.8e-04 0.12 0.15 0.14 0.16 6.3e-03 2.8e-03 3.7e-03 1.8e-03
4 PL gene expression Klhl18 0.02 0.03 5.4e-03 0.01 0.01 0.01 0.01 9.9e-03 8.6e-03 1.1e-02 1.4e-02
5 Eye intron excision ratio chr8_110427892_110459176 0.7 0.17 3.8e-09 0.22 0.35 0.25 0.24 2.6e-04 2.0e-06 9.2e-05 1.5e-04
6 Eye intron excision ratio chr8_110427892_110437437 0.65 0.19 4.2e-08 0.17 0.35 0.27 0.27 1.2e-03 2.0e-06 4.1e-05 4.5e-05
7 PL mRNA stability Klhl18 0.04 0.04 1.0e-04 0.03 0.03 0.02 0.03 2.3e-04 1.9e-04 1.5e-03 2.2e-04
8 Liver gene expression Klhl18 0.18 0.11 0.0e+00 0.15 0.15 0.15 0.16 1.4e-16 8.7e-17 1.1e-16 6.4e-17
9 NAcc mRNA stability Klhl18 0.04 0.03 2.7e-04 0.03 0.03 0.03 0.03 1.4e-04 1.7e-04 1.3e-04 1.7e-04
10 LHb gene expression Klhl18 0.41 0.34 4.7e-03 0.03 0.02 0.02 0.02 6.4e-02 1.1e-01 1.4e-01 8.8e-02
11 Brain mRNA stability Klhl18 0.04 0.04 1.4e-03 0.03 0.03 0.02 0.02 1.0e-03 2.1e-03 4.8e-03 3.6e-03
12 OFC mRNA stability Klhl18 0.15 0.13 8.3e-03 0.07 0.07 0.08 0.08 1.1e-02 1.1e-02 7.1e-03 5.6e-03
13 Adipose gene expression Klhl18 0.13 0.09 2.6e-08 0.07 0.07 0.06 0.07 4.0e-08 2.0e-08 7.3e-07 4.8e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.00.00.10.20.40.2-0.2-0.20.20.20.0-0.20.2-0.2-0.00.1
Area under the delay curve2.12.22.6-1.6-1.4-1.51.61.5-1.5-1.5-1.51.4-1.61.3-1.4-1.5
BMI with tail0.31.01.90.71.21.4-1.0-1.01.01.01.0-0.91.1-1.01.20.4
BMI without tail1.63.33.81.71.91.9-1.9-1.91.91.91.8-1.82.0-1.81.51.5
Body weight6.527.329.15.25.35.4-5.3-5.35.35.35.1-5.35.3-5.24.94.8
Weight adjusted by age0.20.20.30.50.50.5-0.5-0.50.50.50.5-0.40.5-0.4-0.10.5
Bone surface0.10.10.4-0.3-0.1-0.20.30.3-0.3-0.3-0.50.4-0.30.4-0.6-0.4
Bone volume0.00.00.2-0.10.1-0.00.10.1-0.1-0.1-0.30.1-0.10.1-0.4-0.2
Breakpoint value in progressive ratio session0.20.20.50.40.40.3-0.3-0.30.30.30.3-0.60.4-0.60.70.3
Number of licking bursts0.20.20.4-0.4-0.7-0.60.40.4-0.5-0.4-0.50.4-0.30.2-0.1-0.4
Context. condit. distance diff. score0.00.00.00.0-0.1-0.0-0.0-0.00.00.0-0.10.10.00.1-0.10.0
Locomotion velocity, session 10.10.10.3-0.3-0.2-0.20.30.3-0.3-0.3-0.20.4-0.20.5-0.3-0.4
Locomotion distance, session 10.70.91.40.91.21.2-1.0-1.01.01.01.0-0.91.1-0.70.90.7
Locomotion velocity, session 20.30.30.6-0.7-0.5-0.40.60.6-0.6-0.6-0.50.6-0.50.7-0.6-0.7
Locomotion distance, session 20.10.10.2-0.30.10.00.10.2-0.2-0.2-0.10.40.00.5-0.5-0.5
Locomotion velocity, session 30.10.10.30.20.60.4-0.3-0.30.30.30.1-0.1-0.1-0.1-0.20.0
Locomotion distance, session 31.21.41.9-1.2-0.9-1.01.11.1-1.1-1.1-1.31.2-1.31.2-1.4-1.3
Stereotopy head waving bouts, day 30.00.10.20.2-0.10.1-0.2-0.20.20.20.2-0.30.2-0.30.40.2
Stereotopy head waving duration, day 30.30.30.50.60.30.3-0.6-0.60.60.60.5-0.60.7-0.60.60.7
Locomotion velocity, session 70.20.20.30.50.60.2-0.5-0.50.50.50.1-0.40.5-0.4-0.10.5
Locomotion distance, session 70.81.01.9-0.9-0.8-1.20.90.9-0.9-0.9-1.21.0-0.80.9-1.4-0.9
Stereotopy head waving bouts, day 70.00.00.1-0.2-0.1-0.10.20.2-0.2-0.2-0.10.2-0.30.2-0.2-0.2
Stereotopy head waving duration, day 70.30.30.50.50.60.7-0.5-0.50.50.50.7-0.50.4-0.50.60.5
Locomotion velocity, session 80.20.20.50.30.70.6-0.4-0.40.40.40.4-0.40.4-0.30.20.1
Locomotion distance, session 80.10.20.60.30.80.6-0.5-0.50.50.50.4-0.20.5-0.1-0.10.1
Degree of sensitization distance1.41.41.91.31.01.0-1.2-1.21.21.21.1-1.21.4-1.21.21.3
Degree of sensitization stereotypy0.00.00.10.10.30.3-0.1-0.10.10.10.3-0.1-0.1-0.10.10.2
Conditioned locomotion3.03.53.8-1.9-1.8-1.91.91.9-1.9-1.9-1.91.8-1.91.9-2.0-1.7
Cocaine response after cond. corrected0.30.30.70.50.30.5-0.5-0.50.50.50.6-0.60.4-0.60.80.6
Cocaine response after cond. not corrected1.82.02.51.41.21.4-1.4-1.41.41.41.4-1.41.3-1.51.61.4
Cocaine response before conditioning1.01.22.01.11.41.4-1.2-1.21.21.21.1-0.91.1-0.90.80.9
Saline control response1.41.92.21.51.51.3-1.4-1.41.41.41.3-1.31.4-1.21.21.5
Bone: connectivity density0.20.30.5-0.5-0.3-0.50.50.5-0.5-0.5-0.50.5-0.60.4-0.7-0.4
Bone: cortical apparent density0.20.30.4-0.6-0.4-0.50.60.5-0.5-0.5-0.50.5-0.70.5-0.7-0.4
Bone: cortical area0.10.20.4-0.4-0.6-0.50.40.4-0.4-0.4-0.40.5-0.30.5-0.6-0.4
Bone: cortical porosity0.00.00.0-0.0-0.0-0.20.10.1-0.1-0.1-0.20.1-0.10.0-0.20.1
Bone: cortical porosity0.10.10.2-0.3-0.3-0.40.40.4-0.4-0.4-0.40.3-0.30.2-0.4-0.2
Bone: cortical thickness0.10.10.20.40.10.3-0.4-0.40.40.40.3-0.30.4-0.30.30.3
Bone: cortical thickness0.00.00.00.1-0.0-0.1-0.1-0.10.10.1-0.0-0.00.1-0.00.10.1
Bone: cortical tissue density0.20.30.5-0.6-0.4-0.50.60.6-0.6-0.6-0.50.6-0.70.5-0.6-0.5
Condit. Reinf. active minus inactive responses0.10.10.20.40.20.2-0.3-0.30.30.30.4-0.30.4-0.40.30.5
Condit. Reinf. active-inactive response ratio0.30.30.50.60.30.4-0.5-0.50.50.50.6-0.50.6-0.50.60.7
Condit. Reinf. active responses0.00.00.1-0.1-0.2-0.20.10.1-0.1-0.10.00.1-0.20.0-0.20.0
Condit. Reinf. inactive responses0.60.81.3-0.9-0.8-0.80.90.9-0.9-0.9-0.80.8-1.20.8-1.0-0.9
Incentive salience index mean0.10.10.1-0.3-0.3-0.30.20.3-0.3-0.3-0.20.3-0.20.2-0.3-0.2
Condit. Reinf. lever presses1.62.22.5-1.6-1.4-1.41.51.5-1.5-1.5-1.51.5-1.41.4-1.5-1.6
Condit. Reinf. active minus inactive responses2.12.62.91.61.61.7-1.6-1.61.61.61.5-1.61.7-1.71.71.4
Condit. Reinf. active-inactive response ratio1.71.82.31.31.31.3-1.3-1.31.31.31.3-1.41.3-1.51.51.2
Condit. Reinf. active responses1.82.52.91.61.61.7-1.6-1.61.61.61.5-1.61.6-1.61.61.5
Condit. Reinf. inactive responses0.00.00.1-0.1-0.1-0.00.10.1-0.1-0.1-0.10.2-0.00.3-0.2-0.1
Condit. Reinf. lever presses2.53.43.81.81.91.9-1.8-1.81.81.81.8-1.91.8-1.81.91.6
Condit. Reinf. lever reinforcers received2.02.83.11.71.61.8-1.7-1.71.71.71.6-1.71.7-1.61.71.6
Conditioned reinforcement - actives0.40.40.6-0.7-0.7-0.70.60.6-0.6-0.6-0.70.7-0.40.6-0.3-0.7
Conditioned reinforcement - inactives1.01.11.6-1.1-1.3-1.21.01.0-1.0-1.0-1.11.0-1.01.0-1.0-1.0
Conditioned locomotion0.40.40.6-0.8-0.6-0.60.70.7-0.7-0.7-0.60.8-0.50.7-0.3-0.7
Patch foraging indifference point 0 sec0.91.52.01.41.31.1-1.3-1.31.31.31.2-1.21.3-1.00.81.3
Patch foraging indifference point AUC0.10.10.40.20.40.3-0.3-0.30.30.30.4-0.60.2-0.50.50.2
Delay disc. indifference point, 0s delay0.00.00.1-0.3-0.2-0.20.20.2-0.2-0.2-0.20.0-0.2-0.00.2-0.2
Delay disc. indifference point, 16s delay1.11.11.9-1.0-0.9-1.01.01.0-1.0-1.0-1.01.1-1.01.0-1.4-1.0
Delay disc. indifference point, 2s delay0.30.30.4-0.6-0.5-0.60.60.6-0.6-0.6-0.60.4-0.60.4-0.7-0.6
Delay disc. indifference point, 24s delay0.90.91.7-1.0-0.8-0.90.90.9-0.9-0.9-0.90.8-1.00.7-1.3-0.9
Delay disc. indifference point, 4s delay2.22.32.6-1.6-1.5-1.61.61.5-1.5-1.6-1.61.4-1.61.3-1.4-1.5
Delay disc. indifference point, 8s delay2.12.22.5-1.5-1.4-1.51.51.5-1.5-1.5-1.51.4-1.61.3-1.5-1.4
Indifference point function ln k0.30.41.1-0.6-0.4-0.30.50.5-0.5-0.5-0.50.9-0.41.0-1.1-0.8
Indifference point function log k0.30.41.1-0.6-0.4-0.30.50.5-0.5-0.5-0.50.9-0.41.0-1.1-0.8
Patch foraging total patch changes 0 sec1.11.82.31.51.41.2-1.4-1.41.41.41.3-1.31.5-1.11.01.4
Patch foraging total patch changes 12 sec1.01.31.71.31.21.1-1.1-1.11.11.11.1-1.30.9-1.21.01.2
Patch foraging total patch changes 18 sec2.73.54.31.91.61.5-1.8-1.81.81.81.8-2.02.1-2.02.01.9
Patch foraging total patch changes 24 sec3.23.94.42.11.91.9-2.0-2.02.02.01.9-2.12.0-1.92.11.9
Patch foraging total patch changes 6 sec0.10.20.30.50.50.4-0.4-0.40.40.40.4-0.50.3-0.40.30.5
Patch foraging time to switch 0 sec0.10.20.4-0.4-0.6-0.50.40.4-0.4-0.4-0.40.5-0.50.4-0.4-0.3
Patch foraging water rate 0 sec0.10.20.50.40.50.5-0.4-0.40.40.40.5-0.40.7-0.30.50.3
Patch foraging water rate 12 sec0.30.41.00.60.50.5-0.7-0.70.60.70.6-0.71.0-0.60.80.5
Patch foraging water rate 18 sec0.00.00.10.00.10.1-0.1-0.10.10.1-0.00.10.40.20.1-0.2
Patch foraging water rate 24 sec0.81.11.41.01.01.1-1.0-1.01.01.01.2-1.11.0-1.01.21.0
Patch foraging water rate 6 sec0.30.40.70.70.80.9-0.7-0.70.70.70.7-0.40.7-0.30.50.5
Seeking ratio, delayed vs. immediate footshock2.52.93.6-1.7-1.9-1.81.81.8-1.8-1.8-1.91.5-1.71.7-0.8-1.7
Distance traveled before self-admin0.00.00.10.0-0.2-0.1-0.0-0.00.00.1-0.20.10.00.2-0.10.1
Distance traveled after self-admin0.40.41.0-0.5-0.7-0.70.50.5-0.5-0.5-0.70.6-0.51.0-0.8-0.5
Extensor digitorum longus weight0.20.71.0-0.9-0.9-0.80.80.8-0.8-0.8-1.00.7-0.80.6-0.7-0.8
Bone: elastic displacement0.00.10.20.20.10.3-0.2-0.20.20.20.2-0.20.3-0.20.40.2
Bone: elastic work0.40.60.80.70.70.9-0.8-0.80.80.80.7-0.70.8-0.70.70.6
Bone: endosteal estimation0.10.20.40.50.40.2-0.4-0.40.40.40.3-0.50.6-0.40.10.5
Bone: endosteal perimeter1.22.53.5-1.7-1.5-1.51.61.6-1.6-1.6-1.51.6-1.41.6-1.9-1.6
Epididymis fat weight0.30.82.00.80.60.8-0.8-0.80.80.80.9-1.00.7-1.11.40.8
Delta time in closed arm before/after self-admin0.10.10.1-0.3-0.3-0.30.40.4-0.4-0.4-0.30.3-0.30.1-0.1-0.4
Delta time in open arm before/after self-admin0.20.20.30.50.40.3-0.5-0.50.50.50.3-0.30.5-0.2-0.50.5
Diff in mean of infusions in LGA sessions0.00.00.1-0.1-0.20.10.10.1-0.1-0.1-0.00.0-0.1-0.10.4-0.0
Delay discount exponential model param2.52.63.01.71.61.7-1.7-1.71.71.71.7-1.51.7-1.41.61.6
Extinction: sum of active levers before priming0.00.00.20.10.10.0-0.1-0.10.10.10.0-0.40.2-0.40.20.1
Active lever presses in extinction session 60.30.30.80.60.50.4-0.5-0.50.50.50.2-0.50.7-0.9-0.20.6
Bone: final force0.81.31.71.21.11.3-1.2-1.21.21.21.3-1.11.2-1.01.01.1
Bone: final moment1.11.72.21.31.31.5-1.3-1.31.31.31.4-1.31.4-1.11.21.2
Food consumed during 24 hour testing period1.41.72.21.31.41.5-1.3-1.31.31.31.4-1.21.4-1.21.21.2
Glucose0.30.50.80.60.90.8-0.6-0.60.60.60.7-0.80.5-0.90.90.5
Heart weight2.63.74.72.01.82.2-1.9-1.91.91.92.2-1.81.8-1.81.91.8
Delay discount hyperbolic model param2.52.63.01.71.61.7-1.7-1.71.71.71.7-1.41.7-1.41.51.6
Intermittent access intake day 1-15 change0.70.71.4-0.8-0.9-0.70.80.8-0.8-0.8-0.80.7-0.80.8-1.2-0.7
Intermittent access intake escalation0.60.61.4-0.8-0.8-0.70.70.7-0.7-0.7-0.80.6-0.60.7-1.2-0.6
Intermittent access intake escalation 20.00.00.30.10.00.2-0.1-0.10.10.10.1-0.00.20.2-0.50.1
Intermitt. access day 1 inactive lever presses0.00.00.1-0.00.00.10.00.1-0.1-0.10.00.20.10.3-0.1-0.1
Intermitt. access day 15 inactive lever presses0.80.81.1-0.9-1.0-1.00.90.9-0.9-0.9-1.01.0-0.80.9-1.0-0.8
Intermitt. access escalation Index0.00.00.20.00.2-0.0-0.0-0.00.00.0-0.0-0.00.10.2-0.40.0
Intermittent access day 1 total infusions0.00.00.1-0.2-0.2-0.30.20.2-0.2-0.2-0.30.20.00.1-0.2-0.2
Intermittent access day 15 total infusions0.50.51.3-0.7-0.7-0.70.60.6-0.6-0.6-0.80.7-0.50.7-1.2-0.6
Intermittent access terminal intake (last 3 days)0.20.30.9-0.5-0.4-0.50.40.4-0.4-0.4-0.60.6-0.20.5-1.0-0.4
Intermittent access total infusions0.60.71.3-0.8-0.8-0.80.70.8-0.8-0.8-0.90.9-0.50.8-1.1-0.8
Intermittent access day 1 locomotion0.10.10.3-0.4-0.5-0.60.30.4-0.4-0.3-0.50.4-0.20.4-0.2-0.4
Intermittent access day 15 total locomotion0.70.71.3-0.9-0.7-0.90.80.8-0.8-0.8-0.90.9-0.70.9-1.1-0.8
Intermittent access total locomotion1.21.41.7-1.3-1.0-1.11.21.2-1.2-1.2-1.11.3-1.01.2-1.2-1.2
Intermittent access standard deviation0.10.10.30.40.20.3-0.4-0.40.40.40.3-0.20.5-0.10.00.4
Left kidney weight0.72.03.51.21.81.9-1.4-1.41.41.41.5-1.41.0-1.41.11.0
Right kidney weight0.20.51.40.51.21.1-0.7-0.70.70.70.7-0.60.2-0.50.10.4
Cocaine induced anxiety0.60.70.9-0.8-0.8-0.70.80.8-0.8-0.8-0.70.9-0.90.9-0.8-0.8
Post-drug Anxiety0.20.20.4-0.4-0.5-0.40.50.5-0.5-0.5-0.40.4-0.70.5-0.4-0.4
Baseline Anxiety0.20.20.4-0.4-0.4-0.60.40.4-0.4-0.4-0.60.2-0.40.2-0.5-0.3
Tail length6.921.023.14.84.64.4-4.7-4.74.74.74.6-4.74.6-4.54.04.7
Length with tail9.735.538.56.26.05.9-6.1-6.16.16.15.9-6.15.9-5.95.25.9
Length without tail6.614.415.93.93.84.0-3.8-3.83.83.83.8-3.93.7-3.73.73.7
Times rat made contact with spout0.50.60.90.80.70.9-0.7-0.70.70.70.9-0.60.7-0.60.80.7
Lifetime Intake0.40.50.7-0.7-0.7-0.70.60.7-0.7-0.7-0.80.8-0.40.6-0.9-0.7
Liver weight, left0.10.10.20.40.40.2-0.3-0.30.30.30.2-0.40.2-0.40.30.5
Liver weight, right1.32.22.91.51.71.6-1.5-1.51.51.51.5-1.51.2-1.51.41.4
Locomotor activity5.58.79.63.02.92.8-3.1-3.13.13.12.9-2.83.1-2.82.63.0
Locomotor testing distance5.18.59.53.12.92.6-3.1-3.13.13.12.7-2.93.1-2.92.62.9
Locomotor testing rearing0.20.30.70.60.20.0-0.6-0.60.60.60.1-0.60.8-0.60.50.7
Locomotion in novel chamber0.20.20.3-0.5-0.6-0.30.50.5-0.5-0.5-0.30.5-0.50.40.4-0.5
Locomotion in novel chamber post-restriction0.81.02.10.90.91.0-1.0-1.01.01.01.1-1.00.9-0.71.40.9
Fecal boli incidents, locomotor time 10.40.51.10.70.50.6-0.6-0.60.60.60.6-0.70.8-0.61.00.6
Change in fecal boli incidents, locomotor task0.10.10.60.20.10.1-0.1-0.10.10.10.2-0.3-0.1-0.30.80.2
Time >=10cm from walls, locomotor time 10.10.10.2-0.3-0.2-0.30.30.3-0.3-0.3-0.30.3-0.40.3-0.4-0.3
Bouts of movement, locomotor time 10.00.00.20.20.10.1-0.1-0.10.10.10.1-0.10.2-0.00.40.2
Total resting periods, locomotor time 10.00.00.30.20.10.1-0.1-0.10.10.10.1-0.10.20.00.60.1
Rest time, locomotor task time 10.50.60.9-0.7-0.9-0.90.80.8-0.8-0.8-0.80.7-0.70.80.1-0.8
Distance moved, locomotor task time 11.82.02.41.31.41.6-1.4-1.41.41.41.5-1.41.5-1.51.01.3
Vertical activity count, locomotor time 10.90.91.31.01.01.2-1.0-1.01.01.01.1-0.81.0-0.80.90.9
Time >=10cm from walls, locomotor time 21.61.72.11.41.31.2-1.3-1.31.31.31.3-1.31.4-1.31.31.3
Bouts of movement, locomotor time 20.00.00.00.0-0.1-0.2-0.0-0.00.00.0-0.1-0.10.1-0.1-0.10.0
Total resting periods, locomotor time 20.10.10.3-0.3-0.4-0.50.20.2-0.2-0.2-0.40.2-0.20.2-0.4-0.3
Rest time, locomotor task time 20.10.10.2-0.1-0.4-0.40.20.2-0.2-0.2-0.30.3-0.20.40.3-0.2
Distance moved, locomotor task time 21.11.32.01.11.31.4-1.1-1.11.11.11.3-1.11.3-1.20.51.0
Vertical activity count, locomotor time 20.10.10.30.30.50.5-0.3-0.30.30.30.4-0.20.6-0.2-0.10.2
Light reinforcement 10.71.31.71.11.21.1-1.1-1.11.11.11.1-1.31.0-1.21.01.1
Light reinforcement 20.10.20.5-0.40.0-0.20.30.3-0.3-0.3-0.40.3-0.70.4-0.7-0.4
Bone: marrow area0.10.20.40.50.40.2-0.4-0.40.40.40.3-0.50.6-0.40.20.5
Bone: maximum diameter0.40.81.0-0.9-1.0-0.80.90.9-0.9-0.9-0.71.0-0.71.0-0.9-0.9
Bone: maximum force0.71.21.41.21.11.1-1.1-1.11.11.11.1-1.11.2-1.00.81.1
Bone: maximum moment0.81.41.71.21.11.2-1.2-1.21.21.21.2-1.21.3-1.10.91.2
Mean time between licks in bursts1.11.61.8-1.3-1.3-1.31.31.3-1.3-1.3-1.31.2-1.31.1-1.1-1.4
Mean num. licks in bursts0.60.71.30.91.11.2-0.9-0.90.90.91.0-0.70.7-0.50.50.8
Cd content in liver2.52.83.51.81.31.4-1.6-1.61.61.61.6-1.81.8-1.81.91.8
Co content in liver0.00.00.40.1-0.1-0.2-0.1-0.10.10.10.10.10.20.1-0.70.1
Cu content in liver4.35.26.82.32.12.1-2.2-2.22.22.22.3-2.42.3-2.32.62.2
Fe content in liver2.02.43.81.71.11.2-1.4-1.41.41.51.7-1.61.6-1.61.91.8
K content in liver0.80.81.10.81.01.0-0.8-0.80.80.81.0-0.90.7-0.81.00.6
Mg content in liver0.00.00.1-0.10.20.20.00.0-0.0-0.00.30.0-0.10.00.0-0.3
Mn content in liver0.60.61.40.81.21.0-0.8-0.80.80.80.9-0.70.7-0.70.30.6
Na content in liver0.40.50.70.80.60.5-0.6-0.60.60.60.8-0.60.7-0.60.60.8
Rb content in liver1.21.52.81.40.70.6-1.2-1.21.21.21.0-1.41.4-1.41.31.7
Se content in liver0.10.10.20.10.30.4-0.2-0.20.20.20.5-0.2-0.1-0.10.50.1
Sr content in liver0.00.00.1-0.10.30.3-0.0-0.00.00.00.00.1-0.10.1-0.1-0.3
Zn content in liver4.65.16.62.22.22.3-2.2-2.22.22.22.4-2.22.3-2.22.62.0
Bone: minimum diameter0.40.71.4-0.9-0.8-0.80.80.8-0.8-0.8-0.80.9-0.70.9-1.2-0.9
Time in familiar zone, hab. session 11.41.32.3-1.1-1.5-1.51.11.1-1.1-1.1-1.21.1-0.91.1-1.1-0.9
Time in novel zone, hab. session 10.60.61.30.81.01.1-0.8-0.80.80.80.9-0.50.6-0.50.60.7
Total zone transitions, hab. session 10.50.71.40.81.21.0-0.9-0.90.90.90.9-0.60.8-0.50.40.5
Total locomotion distance, hab. session 10.20.30.60.50.80.7-0.6-0.60.60.60.6-0.60.5-0.60.50.4
Locomotion velocity, hab. session 10.30.40.70.50.80.8-0.6-0.60.60.60.7-0.60.5-0.60.50.4
Time in familiar zone, hab. session 20.50.51.0-0.8-1.0-0.90.70.8-0.8-0.7-0.70.7-0.50.6-0.6-0.7
Time in novel zone, hab. session 20.00.00.10.20.30.2-0.2-0.20.20.20.10.00.10.0-0.00.2
Total zone transitions, hab. session 20.00.00.20.10.40.4-0.2-0.20.20.20.20.10.10.1-0.1-0.2
Total locomotion distance, hab. session 20.30.30.50.50.70.7-0.6-0.60.60.50.6-0.60.5-0.60.60.3
Locomotion velocity, hab. session 20.20.20.40.40.70.7-0.4-0.40.40.40.6-0.50.3-0.50.50.2
Novel to familiar place preference ratio0.90.91.60.91.21.0-0.9-0.90.90.90.9-0.91.3-0.90.70.9
Novelty place preference0.90.91.61.01.21.0-0.9-0.90.90.90.9-0.81.3-0.90.60.9
Time in novel zone, NPP test1.21.22.01.11.31.1-1.1-1.11.11.11.0-1.01.4-1.00.81.1
Total zone transitions, NPP test2.02.84.71.52.22.1-1.7-1.71.71.71.8-1.41.6-1.41.31.2
Total locomotion distance, NPP test1.01.32.01.01.31.4-1.1-1.11.11.11.3-1.11.0-1.11.20.8
Locomotion velocity, NPP test1.01.52.31.11.41.5-1.2-1.21.21.21.3-1.11.1-1.11.20.9
Intraocular pressure1.21.62.21.31.11.0-1.3-1.21.31.31.3-1.31.3-1.31.51.5
Delta distance traveled before/after self-admin0.20.20.6-0.5-0.4-0.50.40.4-0.4-0.4-0.50.4-0.40.6-0.8-0.4
Delta ambulatory time before/after self-admin0.20.20.40.50.50.3-0.6-0.50.50.50.3-0.60.7-0.40.10.5
Parametrial fat weight1.12.22.71.51.61.5-1.5-1.51.51.51.5-1.61.3-1.51.31.4
Pavlov. Cond. lever latency5.67.08.22.92.72.6-2.7-2.72.72.72.7-2.62.6-2.52.32.8
Pavlov. Cond. magazine entry latency7.09.09.7-3.1-3.1-3.03.03.0-3.0-3.0-3.03.0-2.93.0-2.8-3.0
Pavlov. Cond. change in total contacts1.81.92.6-1.4-1.6-1.51.41.4-1.4-1.4-1.41.3-1.31.3-1.0-1.3
Pavlov. Cond. index score6.98.79.7-3.1-3.1-3.03.03.0-3.0-3.0-3.02.9-2.82.9-2.6-3.0
Pavlov. Cond. latency score6.78.69.5-3.1-3.0-2.92.93.0-3.0-3.0-2.92.9-2.82.9-2.6-3.0
Pavlov. Cond. lever contacts3.23.84.6-2.1-1.9-1.82.02.0-2.0-2.0-1.92.0-1.91.9-1.6-2.1
Pavlov. Cond. magazine entry number7.99.810.93.33.33.2-3.2-3.23.23.23.1-3.13.0-3.02.93.1
Pavlov. Cond. intertrial magazine entries0.40.50.60.70.70.5-0.7-0.70.70.70.7-0.70.6-0.70.50.8
Pavlov. Cond. lever-magazine prob. diff.6.17.68.8-2.9-3.0-2.82.82.8-2.8-2.8-2.82.7-2.62.7-2.4-2.8
Pavlov. Cond. response bias7.49.010.0-3.2-3.2-3.03.03.0-3.1-3.1-3.03.0-2.92.9-2.7-3.1
Pavlov. Cond. lever latency0.40.50.8-0.7-0.8-0.90.70.7-0.7-0.7-0.70.6-0.90.7-0.7-0.5
Pavlov. Cond. magazine entry latency0.10.20.4-0.5-0.3-0.30.40.4-0.4-0.4-0.40.4-0.30.3-0.3-0.6
Pavlov. Cond. change in total contacts2.33.23.91.81.71.8-1.8-1.81.81.81.8-1.82.0-1.81.91.6
Pavlov. Cond. index score0.10.10.20.20.30.4-0.3-0.30.30.30.2-0.20.4-0.30.4-0.0
Pavlov. Cond. latency score0.00.00.10.10.20.3-0.2-0.20.20.20.2-0.10.3-0.20.3-0.1
Pavlov. Cond. lever contacts1.01.31.61.11.21.3-1.2-1.11.11.11.1-1.11.3-1.21.20.9
Pavlov. Cond. magazine entry number0.40.50.80.80.70.6-0.7-0.70.70.70.7-0.70.5-0.60.60.9
Pavlov. Cond. intertrial magazine entries0.40.50.8-0.6-0.8-0.90.70.7-0.7-0.7-0.70.7-0.40.8-0.9-0.4
Pavlov. Cond. lever-magazine prob. diff.0.00.10.10.10.30.4-0.2-0.20.20.20.2-0.20.3-0.30.3-0.1
Pavlov. Cond. response bias0.00.10.20.10.30.4-0.2-0.20.20.20.1-0.20.4-0.30.3-0.1
Time in closed arm before self-admin1.51.61.91.31.21.2-1.4-1.41.41.41.3-1.31.3-1.21.11.3
Time in closed arm after self-admin0.00.00.10.10.20.2-0.1-0.10.10.10.3-0.30.1-0.30.40.1
Time in open arm before self-admin0.91.01.3-1.0-1.0-0.91.11.1-1.1-1.1-1.11.0-0.80.8-0.8-1.1
Time in open arm after self-admin0.30.41.9-0.4-0.4-0.50.40.4-0.4-0.4-0.60.6-0.30.6-1.4-0.4
Bone: periosteal estimation0.00.00.10.10.00.0-0.1-0.10.10.10.1-0.10.3-0.0-0.20.1
Bone: periosteal perimeter1.32.12.9-1.5-1.4-1.41.41.4-1.4-1.4-1.31.5-1.31.5-1.7-1.4
Bone: post-yield work0.00.00.10.20.20.2-0.2-0.20.20.20.1-0.20.3-0.1-0.00.1
Progressive ratio test 1 active lever presses0.00.00.0-0.2-0.1-0.20.10.1-0.1-0.1-0.20.00.1-0.0-0.2-0.1
Progressive ratio test 1 breakpoint0.00.00.1-0.3-0.2-0.30.20.2-0.2-0.2-0.30.1-0.10.1-0.2-0.2
Progressive ratio test 1 inactive lever presses0.40.40.7-0.7-0.8-0.80.70.7-0.7-0.7-0.70.6-0.50.7-0.3-0.7
Progressive ratio test 2 active lever presses1.01.11.3-1.2-1.0-1.11.01.0-1.0-1.0-1.11.1-0.90.9-1.1-1.0
Progressive ratio test 2 breakpoint0.80.91.1-1.1-0.9-0.90.91.0-1.0-1.0-0.91.0-0.80.9-1.0-1.0
Progressive ratio test 2 inactive lever presses2.42.83.1-1.7-1.8-1.71.61.6-1.6-1.6-1.71.8-1.41.8-1.7-1.7
Incentive Sensitization - Responses1.71.82.0-1.4-1.3-1.31.31.3-1.3-1.3-1.31.4-1.31.3-1.2-1.3
Incentive Sensitization - Breakpoint1.71.72.0-1.4-1.3-1.31.31.3-1.3-1.3-1.31.4-1.31.3-1.3-1.3
Sum of active levers in priming session hrs 5-60.50.50.60.80.70.7-0.7-0.70.70.70.7-0.70.8-0.60.50.7
Progressive ratio3.54.15.32.12.12.1-2.0-2.02.02.02.1-1.91.9-1.82.31.9
Food seeking constrained by brief footshock0.81.01.9-1.0-0.8-0.71.01.0-1.0-1.0-0.81.2-0.91.2-1.4-1.0
Seeking ratio, punishment vs. effort5.66.98.8-2.8-2.6-2.52.62.6-2.6-2.6-2.62.7-2.42.5-3.0-2.6
Retroperitoneal fat weight0.62.02.51.51.61.5-1.5-1.51.51.51.5-1.41.2-1.41.11.4
Reaction time number correct0.40.51.0-0.7-0.8-0.80.70.7-0.7-0.7-0.70.9-0.20.9-1.0-0.6
Reaction time mean minus median0.10.10.30.10.40.4-0.2-0.20.20.20.2-0.4-0.2-0.50.40.1
Reaction time mean minus median AUC0.30.40.80.50.60.5-0.5-0.50.50.50.5-0.80.2-0.90.90.4
Reaction time num false alarms0.30.41.4-0.6-0.7-0.90.60.6-0.6-0.6-0.70.5-0.50.5-1.2-0.5
Reaction time num false alarms AUC0.10.10.9-0.2-0.2-0.40.20.2-0.2-0.2-0.20.2-0.20.3-1.0-0.1
Reaction time trials correct on left0.40.51.0-0.7-0.8-0.80.70.7-0.7-0.7-0.70.9-0.20.9-1.0-0.6
Reaction time trials on left0.40.61.1-0.7-0.8-0.80.70.7-0.7-0.7-0.70.9-0.20.9-1.0-0.6
Reaction time mean0.00.00.10.10.00.0-0.1-0.10.10.10.2-0.20.0-0.30.20.1
Reaction time mean AUC0.00.00.10.00.0-0.1-0.0-0.00.00.00.1-0.1-0.1-0.30.10.1
Median of all reaction times0.00.00.00.1-0.0-0.0-0.1-0.10.10.10.2-0.00.2-0.10.00.2
Reaction time omissions0.20.20.4-0.4-0.7-0.70.50.5-0.5-0.5-0.40.4-0.40.0-0.3-0.3
Reaction time false alarm rate0.00.00.3-0.1-0.1-0.20.10.1-0.1-0.1-0.1-0.0-0.30.0-0.5-0.0
Reaction time premature initiation rate2.22.93.41.71.81.7-1.7-1.71.71.71.7-1.81.5-1.81.61.7
Reaction time premature initiations1.01.41.51.21.21.2-1.2-1.21.21.21.1-1.21.2-1.20.81.2
Std. dev. reaction times0.10.20.50.30.40.3-0.4-0.30.30.30.4-0.50.1-0.70.40.3
Reaction time trials completed0.40.61.1-0.7-0.8-0.80.70.7-0.7-0.7-0.70.9-0.20.9-1.0-0.6
Reaction time trials AUC0.50.71.2-0.8-0.9-0.90.80.8-0.8-0.8-0.81.0-0.21.0-1.1-0.7
Run reversals in cocaine runway, females1.91.92.7-1.3-1.2-1.21.31.3-1.3-1.3-1.21.6-1.61.5-1.6-1.2
Run reversals in cocaine runway, males0.60.60.80.90.70.9-0.8-0.80.80.80.8-0.60.8-0.60.80.7
Latency to leave start box in cocaine runway0.50.51.40.70.60.8-0.6-0.60.60.60.8-0.80.6-0.71.20.6
Latency to leave start box in cocaine runway, F1.41.51.81.21.11.3-1.2-1.21.21.21.3-1.31.3-1.21.21.1
Latency to leave start box in cocaine runway, M0.30.30.5-0.4-0.6-0.50.60.6-0.6-0.6-0.40.3-0.70.40.3-0.5
Std. dev. time between licks in bursts4.35.16.2-2.3-2.5-2.42.22.3-2.3-2.2-2.42.2-2.02.2-2.1-2.3
Total sessions with >9 infusions0.10.10.3-0.4-0.5-0.40.20.3-0.3-0.3-0.40.1-0.1-0.20.3-0.3
Short access day 1 total inactive lever presses3.84.35.5-2.2-2.3-2.32.12.1-2.1-2.1-2.31.9-1.81.8-1.6-2.1
Short access day 10 total inactive lever presses0.00.00.0-0.0-0.2-0.10.10.1-0.1-0.1-0.1-0.0-0.10.00.0-0.1
Short access day 1 total infusions0.80.91.3-1.1-1.1-1.11.01.0-1.0-1.0-1.10.7-0.90.5-0.4-1.0
Short access day 10 total infusions0.10.10.1-0.3-0.2-0.30.20.2-0.3-0.2-0.30.40.00.3-0.4-0.3
Short access total infusions0.50.60.7-0.9-0.8-0.90.80.8-0.8-0.8-0.90.8-0.60.6-0.7-0.8
Short access day 1 locomotion0.10.10.1-0.3-0.3-0.20.20.2-0.2-0.2-0.20.3-0.10.10.2-0.3
Short access day 10 total locomotion0.00.00.20.10.20.2-0.2-0.10.10.10.20.00.20.20.50.1
Short access total locomotion0.00.00.1-0.2-0.1-0.10.10.1-0.1-0.1-0.10.30.00.30.3-0.2
One hour access (0.3 mA shock)0.20.20.9-0.5-0.3-0.50.40.4-0.4-0.4-0.60.5-0.20.4-1.0-0.4
Compulsive drug intake0.00.00.1-0.00.1-0.10.10.1-0.1-0.1-0.1-0.0-0.1-0.0-0.2-0.0
One hour access (shock baseline)0.10.20.5-0.4-0.4-0.40.30.3-0.3-0.3-0.40.5-0.00.5-0.7-0.4
Social response proportion0.60.60.80.90.80.9-0.8-0.80.80.80.8-0.70.7-0.70.40.9
Social responses0.40.50.70.70.90.9-0.7-0.70.70.70.6-0.70.8-0.70.40.7
Social time0.50.71.6-0.7-0.7-0.60.80.7-0.7-0.7-0.90.9-0.90.8-1.3-0.7
Soleus weight3.811.211.83.43.43.4-3.4-3.43.43.43.4-3.43.4-3.33.33.1
Bone: stiffness0.10.20.30.50.50.5-0.5-0.50.50.50.5-0.50.5-0.40.20.6
Tibialis anterior weight0.00.00.10.10.10.2-0.1-0.10.10.10.0-0.30.1-0.30.20.1
Time to tail flick, vehicle, before self-admin2.22.34.11.61.21.3-1.4-1.41.41.41.4-1.61.3-1.82.01.5
Time to tail flick, vehicle, after self-admin0.50.60.70.80.70.8-0.8-0.80.80.80.8-0.60.8-0.50.70.7
Time to tail flick, test, before self-admin0.10.10.40.30.60.5-0.2-0.30.30.30.5-0.30.3-0.40.10.2
Time to tail flick, test, after self-admin0.10.10.2-0.3-0.4-0.30.40.4-0.4-0.4-0.30.3-0.10.3-0.1-0.4
Delta time to tail flick, vehicle, before/after SA0.60.61.3-0.8-0.6-0.50.70.7-0.7-0.7-0.70.8-0.61.1-0.8-0.8
Delta time to tail flick, test, before/after SA0.40.40.6-0.6-0.8-0.70.60.6-0.6-0.6-0.70.6-0.50.7-0.2-0.6
Tibia length6.518.321.54.34.64.6-4.4-4.44.44.44.3-4.24.2-3.93.93.9
Ambulatory time before self-admin0.10.10.2-0.3-0.4-0.50.30.3-0.3-0.3-0.40.3-0.30.4-0.4-0.2
Ambulatory time after self-admin0.10.10.4-0.2-0.4-0.40.10.1-0.1-0.1-0.50.2-0.10.5-0.6-0.1
Bone: tissue strength3.13.03.41.81.61.7-1.8-1.71.71.81.7-1.81.8-1.71.61.7
Total heroin consumption1.21.42.31.21.01.0-1.2-1.21.21.21.0-1.21.5-1.21.01.2
Bone: trabecular number0.61.01.7-1.0-0.6-0.91.00.9-1.0-1.0-1.11.0-1.00.9-1.3-1.0
Bone: trabecular spacing1.41.92.21.41.11.2-1.4-1.41.41.41.5-1.41.4-1.41.51.4
Bone: trabecular thickness0.00.00.20.10.50.4-0.1-0.10.10.10.1-0.10.0-0.20.1-0.0
Bone: trabecular tissue density0.20.30.50.60.70.6-0.6-0.60.60.60.6-0.60.6-0.60.40.6
Water consumed over 24 hours0.00.00.0-0.1-0.10.20.10.1-0.1-0.10.10.2-0.00.2-0.0-0.2
Number of responses in last shaping day0.90.91.2-1.0-1.0-1.10.90.9-0.9-0.9-1.10.7-0.80.7-1.1-0.9