Hub : Genes

Klhl18

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Eye isoform ratio XR_005488466.2 0.28 0.21 7.1e-03 0.07 0.06 -0.02 0.03 3.4e-02 5.1e-02 6.5e-01 1.0e-01
2 Liver gene expression Klhl18 0.16 0.1 1.7e-16 0.13 0.14 0.13 0.14 1.2e-14 4.5e-15 1.5e-14 8.5e-15
3 Eye intron excision ratio chr8_119306289_119337569 0.68 0.18 6.3e-09 0.32 0.36 0.32 0.37 7.2e-06 1.7e-06 7.2e-06 9.8e-07
4 Eye intron excision ratio chr8_119306289_119315833 0.66 0.19 2.7e-08 0.28 0.37 0.33 0.38 3.2e-05 9.4e-07 5.5e-06 8.3e-07
5 NAcc gene expression Klhl18 0.02 0.02 1.9e-03 0.01 0.01 0.01 0.01 6.4e-03 3.8e-03 1.1e-02 1.0e-02
6 NAcc mRNA stability Klhl18 0.03 0.03 3.1e-05 0.02 0.03 0.02 0.02 4.5e-04 9.3e-05 1.1e-03 9.2e-04
7 Eye mRNA stability Klhl18 0.5 0.25 5.2e-05 0.24 0.23 0.32 0.23 1.5e-04 2.1e-04 8.7e-06 1.6e-04
8 Brain mRNA stability Klhl18 0.06 0.06 4.7e-04 0.03 0.03 0.03 0.03 4.1e-04 9.6e-04 2.0e-03 1.0e-03
9 Brain gene expression Klhl18 0.05 0.04 8.1e-05 0.04 0.05 0.04 0.04 1.2e-04 2.8e-05 4.3e-05 5.6e-05
10 PL mRNA stability Klhl18 0.04 0.04 1.6e-04 0.04 0.03 0.03 0.03 1.0e-04 1.5e-04 1.2e-04 1.4e-04
11 Adipose gene expression Klhl18 0.09 0.08 9.1e-05 0.02 0.04 0.03 0.03 1.5e-03 3.3e-05 6.9e-04 4.6e-04
12 LHb gene expression Klhl18 0.66 0.23 9.3e-03 0.03 0.03 0.08 0.03 5.9e-02 5.6e-02 5.3e-03 7.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.00.00.0-0.00.0-0.00.00.00.0-0.2-0.0-0.10.00.10.0
Area under the delay curve1.61.92.21.5-1.51.5-1.5-1.5-1.51.4-1.41.4-1.2-1.40.6
BMI with tail0.10.42.9-0.80.6-0.60.50.50.5-0.40.3-0.40.3-0.11.7
BMI without tail0.51.41.9-1.41.3-1.31.11.31.2-1.31.1-1.21.10.91.0
Body weight4.519.725.1-5.04.9-4.84.74.84.8-4.54.4-4.64.44.0-0.1
Weight adjusted by age0.00.00.00.10.0-0.0-0.00.00.00.10.1-0.00.00.00.1
Bone surface0.10.30.60.4-0.40.4-0.5-0.5-0.50.4-0.70.5-0.5-0.60.8
Bone volume0.10.10.30.2-0.20.2-0.3-0.2-0.20.1-0.40.3-0.3-0.30.6
Breakpoint value in progressive ratio session0.10.10.30.4-0.40.5-0.4-0.4-0.40.5-0.30.4-0.1-0.3-0.0
Number of licking bursts0.20.30.60.7-0.50.5-0.5-0.5-0.50.8-0.60.5-0.4-0.4-0.3
Context. condit. distance diff. score0.00.00.0-0.1-0.0-0.00.0-0.0-0.0-0.0-0.20.0-0.1-0.10.1
Locomotion velocity, session 10.10.10.20.1-0.30.3-0.2-0.3-0.30.1-0.20.3-0.4-0.40.4
Locomotion distance, session 10.81.01.8-1.31.0-1.11.01.01.0-1.30.9-0.90.70.51.0
Locomotion velocity, session 20.40.51.20.4-0.60.6-0.6-0.7-0.70.5-0.80.7-0.8-0.91.1
Locomotion distance, session 20.20.32.3-0.1-0.10.1-0.1-0.2-0.2-0.2-0.40.3-0.5-0.61.5
Locomotion velocity, session 30.20.31.9-0.50.4-0.50.30.30.3-0.60.0-0.30.2-0.01.4
Locomotion distance, session 31.11.23.50.8-0.90.9-1.0-1.0-1.00.7-1.11.0-1.0-1.21.9
Stereotopy head waving bouts, day 30.00.00.2-0.10.1-0.10.10.10.10.20.1-0.10.10.2-0.5
Stereotopy head waving duration, day 30.30.31.2-0.30.5-0.50.50.50.5-0.20.5-0.50.50.6-1.1
Locomotion velocity, session 70.30.30.6-0.30.6-0.60.50.60.6-0.80.3-0.60.70.60.1
Locomotion distance, session 70.50.71.21.1-0.70.7-0.9-0.7-0.70.6-1.00.8-0.7-0.80.9
Stereotopy head waving bouts, day 70.00.00.0-0.1-0.10.1-0.0-0.2-0.2-0.1-0.00.1-0.1-0.1-0.1
Stereotopy head waving duration, day 70.30.30.5-0.70.5-0.60.60.50.5-0.70.6-0.50.50.5-0.2
Locomotion velocity, session 80.30.41.8-0.80.6-0.60.50.50.5-0.70.3-0.40.30.11.3
Locomotion distance, session 80.30.53.0-0.70.5-0.50.50.40.4-1.00.0-0.30.1-0.11.7
Degree of sensitization distance1.41.52.1-0.91.2-1.11.21.21.2-1.11.2-1.21.31.4-1.4
Degree of sensitization stereotypy0.00.10.2-0.30.1-0.20.30.10.1-0.50.2-0.10.20.2-0.2
Conditioned locomotion2.83.33.92.0-2.02.0-2.0-1.9-1.91.6-1.81.9-1.9-1.70.5
Cocaine response after cond. corrected0.20.30.4-0.50.5-0.50.50.50.5-0.20.5-0.50.60.5-0.5
Cocaine response after cond. not corrected1.51.72.1-1.41.4-1.51.41.41.4-1.11.4-1.41.41.3-0.5
Cocaine response before conditioning1.01.21.7-1.31.2-1.31.21.11.1-1.31.0-1.11.00.90.4
Saline control response0.91.11.4-1.01.0-1.01.11.01.0-1.11.1-1.11.01.2-1.1
Bone: connectivity density0.20.40.50.7-0.70.7-0.6-0.7-0.70.4-0.60.6-0.6-0.5-0.3
Bone: cortical apparent density0.20.20.30.4-0.50.4-0.4-0.5-0.50.3-0.40.5-0.5-0.50.2
Bone: cortical area0.20.30.60.5-0.40.5-0.5-0.4-0.40.7-0.80.5-0.5-0.50.2
Bone: cortical porosity0.10.10.40.5-0.40.4-0.4-0.3-0.30.1-0.30.3-0.2-0.1-0.6
Bone: cortical porosity0.10.10.80.4-0.30.4-0.3-0.2-0.20.1-0.20.2-0.10.0-0.9
Bone: cortical thickness0.00.10.1-0.30.3-0.30.30.30.40.00.0-0.30.30.3-0.1
Bone: cortical thickness0.00.00.00.10.00.0-0.00.00.00.1-0.2-0.00.10.0-0.1
Bone: cortical tissue density0.10.20.30.4-0.50.4-0.4-0.5-0.50.3-0.40.5-0.5-0.50.2
Condit. Reinf. active minus inactive responses0.20.21.1-0.20.3-0.40.40.40.4-0.30.4-0.40.50.6-1.0
Condit. Reinf. active-inactive response ratio0.40.51.7-0.40.6-0.60.60.60.6-0.40.7-0.60.70.8-1.3
Condit. Reinf. active responses0.00.00.20.2-0.10.0-0.1-0.1-0.10.2-0.10.00.10.1-0.5
Condit. Reinf. inactive responses0.60.80.90.8-0.90.8-0.9-0.9-0.90.9-1.00.9-0.8-0.90.9
Incentive salience index mean0.00.00.10.2-0.20.2-0.2-0.2-0.20.2-0.30.2-0.2-0.2-0.1
Condit. Reinf. lever presses1.42.02.41.3-1.41.4-1.4-1.4-1.41.3-1.61.5-1.5-1.61.2
Condit. Reinf. active minus inactive responses1.41.82.3-1.51.5-1.51.41.51.5-1.31.3-1.41.21.20.0
Condit. Reinf. active-inactive response ratio1.31.52.0-1.41.4-1.41.31.31.3-1.21.2-1.31.21.10.2
Condit. Reinf. active responses1.21.62.2-1.51.4-1.31.41.41.4-1.21.4-1.41.11.2-0.5
Condit. Reinf. inactive responses0.10.10.30.2-0.30.4-0.3-0.3-0.30.4-0.20.3-0.5-0.3-0.5
Condit. Reinf. lever presses1.92.73.4-1.81.8-1.81.71.81.8-1.71.6-1.71.61.50.1
Condit. Reinf. lever reinforcers received1.52.12.7-1.61.6-1.51.51.61.6-1.31.5-1.51.31.4-0.5
Conditioned reinforcement - actives1.93.34.41.9-1.81.9-1.9-1.8-1.82.1-2.01.9-1.7-1.90.8
Conditioned reinforcement - inactives2.02.93.91.9-1.71.7-1.8-1.7-1.71.9-2.01.7-1.4-1.71.0
Conditioned locomotion0.40.50.70.6-0.70.8-0.7-0.7-0.70.7-0.80.8-0.7-0.80.2
Patch foraging indifference point 0 sec1.01.82.9-1.41.3-1.31.41.31.4-1.71.3-1.31.01.3-1.2
Patch foraging indifference point AUC0.00.00.2-0.10.2-0.20.10.10.1-0.30.1-0.10.40.10.3
Delay disc. indifference point, 0s delay0.00.00.1-0.0-0.10.0-0.0-0.1-0.10.3-0.10.10.2-0.1-0.0
Delay disc. indifference point, 16s delay0.91.01.41.0-1.01.1-1.1-1.0-1.00.9-1.01.0-1.2-1.00.6
Delay disc. indifference point, 2s delay0.30.30.40.6-0.60.6-0.6-0.6-0.60.5-0.50.6-0.3-0.60.2
Delay disc. indifference point, 24s delay0.91.01.11.1-1.11.0-1.1-1.0-1.10.9-1.01.0-0.9-1.00.4
Delay disc. indifference point, 4s delay1.71.82.11.4-1.41.4-1.4-1.4-1.41.4-1.31.4-1.1-1.40.5
Delay disc. indifference point, 8s delay1.82.12.41.5-1.61.5-1.6-1.5-1.61.4-1.51.5-1.4-1.40.6
Indifference point function ln k0.30.62.10.3-0.50.6-0.6-0.6-0.60.4-0.80.6-1.0-0.91.5
Indifference point function log k0.30.62.10.3-0.50.6-0.6-0.6-0.60.4-0.80.6-1.0-0.91.5
Patch foraging total patch changes 0 sec1.01.92.9-1.51.4-1.31.51.41.4-1.71.4-1.41.11.4-1.2
Patch foraging total patch changes 12 sec1.01.31.7-1.11.1-1.21.21.11.1-1.31.1-1.11.21.1-1.0
Patch foraging total patch changes 18 sec2.03.03.6-1.51.7-1.61.71.81.8-1.61.7-1.81.91.9-1.8
Patch foraging total patch changes 24 sec2.03.43.9-1.92.0-1.92.01.91.9-2.01.8-1.91.91.8-0.9
Patch foraging total patch changes 6 sec0.20.30.9-0.50.5-0.50.60.50.4-0.90.6-0.50.40.5-0.7
Patch foraging time to switch 0 sec0.20.30.60.7-0.60.6-0.6-0.6-0.60.8-0.40.5-0.4-0.4-0.4
Patch foraging water rate 0 sec0.10.30.4-0.60.6-0.60.60.50.5-0.60.6-0.50.50.4-0.2
Patch foraging water rate 12 sec0.20.40.5-0.70.7-0.70.70.70.7-0.60.7-0.60.40.50.2
Patch foraging water rate 18 sec0.10.21.2-0.40.4-0.50.30.30.3-0.30.2-0.20.1-0.01.1
Patch foraging water rate 24 sec0.71.01.5-1.11.1-1.11.01.01.0-0.91.2-1.01.01.0-0.3
Patch foraging water rate 6 sec0.50.71.3-0.90.9-1.00.90.80.8-1.10.9-0.80.80.60.3
Seeking ratio, delayed vs. immediate footshock2.02.43.21.7-1.61.7-1.7-1.6-1.61.8-1.71.6-1.0-1.50.9
Distance traveled before self-admin0.20.30.70.7-0.50.5-0.6-0.5-0.50.9-0.40.5-0.6-0.50.2
Distance traveled after self-admin0.20.20.30.5-0.40.3-0.5-0.4-0.40.5-0.40.4-0.4-0.40.4
Extensor digitorum longus weight0.20.70.90.8-0.80.8-0.8-0.8-0.81.0-0.90.8-0.8-0.90.4
Bone: elastic displacement0.10.10.4-0.20.2-0.20.20.20.20.00.2-0.20.20.3-0.6
Bone: elastic work0.30.40.5-0.70.7-0.70.60.70.7-0.50.4-0.60.60.50.3
Bone: endosteal estimation0.00.10.1-0.10.3-0.20.20.40.4-0.40.2-0.30.30.4-0.3
Bone: endosteal perimeter1.22.53.21.5-1.61.7-1.6-1.6-1.61.5-1.71.6-1.8-1.70.8
Epididymis fat weight0.31.01.3-1.11.1-1.01.01.11.1-0.71.1-1.11.01.1-0.6
Delta time in closed arm before/after self-admin0.40.30.40.5-0.60.6-0.6-0.6-0.60.5-0.70.6-0.6-0.60.2
Delta time in open arm before/after self-admin0.30.30.4-0.40.6-0.60.50.60.6-0.60.6-0.60.50.6-0.1
Diff in mean of infusions in LGA sessions0.00.00.3-0.20.00.1-0.10.00.00.5-0.0-0.00.30.0-0.3
Delay discount exponential model param1.92.12.4-1.51.5-1.51.61.51.6-1.41.5-1.51.31.4-0.6
Extinction: sum of active levers before priming0.00.10.10.2-0.20.3-0.3-0.1-0.10.3-0.30.20.4-0.10.1
Active lever presses in extinction session 60.10.10.2-0.10.3-0.10.20.30.3-0.10.2-0.30.40.3-0.3
Bone: final force0.91.41.9-1.41.3-1.31.31.31.3-1.11.0-1.21.11.1-0.2
Bone: final moment1.01.62.2-1.51.4-1.41.41.41.4-1.21.1-1.31.31.2-0.1
Food consumed during 24 hour testing period1.21.62.3-1.51.4-1.31.41.41.4-1.31.3-1.31.11.2-0.2
Glucose0.91.41.8-1.31.3-1.21.21.21.2-1.31.2-1.21.21.1-0.0
Heart weight1.42.22.7-1.71.6-1.61.61.61.6-1.01.4-1.51.61.4-0.8
Delay discount hyperbolic model param2.12.42.7-1.61.6-1.61.71.61.7-1.51.6-1.61.41.5-0.7
Intermittent access intake day 1-15 change0.71.42.11.4-1.21.2-1.2-1.2-1.21.3-1.51.2-1.1-1.20.6
Intermittent access intake escalation1.02.03.01.6-1.41.5-1.5-1.4-1.41.4-1.71.4-1.3-1.40.7
Intermittent access intake escalation 20.20.20.40.6-0.40.4-0.4-0.4-0.40.5-0.70.4-0.4-0.40.2
Intermitt. access day 1 inactive lever presses0.00.10.30.3-0.40.4-0.4-0.4-0.40.5-0.60.4-0.1-0.40.1
Intermitt. access day 15 inactive lever presses1.02.12.71.6-1.51.4-1.5-1.5-1.51.6-1.61.5-1.5-1.40.8
Intermitt. access escalation Index0.00.00.10.1-0.10.1-0.1-0.1-0.1-0.2-0.00.1-0.3-0.10.2
Intermittent access day 1 total infusions0.30.50.60.8-0.70.7-0.8-0.7-0.60.6-0.80.7-0.8-0.70.5
Intermittent access day 15 total infusions1.72.63.51.8-1.61.6-1.7-1.6-1.61.5-1.91.6-1.7-1.60.9
Intermittent access terminal intake (last 3 days)1.41.82.51.5-1.31.4-1.4-1.3-1.31.1-1.61.3-1.4-1.30.8
Intermittent access total infusions2.12.43.21.7-1.51.6-1.7-1.5-1.51.4-1.81.6-1.7-1.60.9
Intermittent access day 1 locomotion0.00.10.2-0.10.3-0.20.20.30.3-0.40.1-0.20.10.20.1
Intermittent access day 15 total locomotion0.30.61.00.8-0.70.8-0.9-0.7-0.70.5-1.00.7-1.0-0.80.5
Intermittent access total locomotion1.01.21.71.1-1.11.1-1.1-1.1-1.10.8-1.31.1-1.2-1.10.6
Intermittent access standard deviation0.00.00.10.3-0.00.1-0.1-0.00.00.2-0.30.00.2-0.00.1
Left kidney weight0.62.83.9-2.01.9-1.71.71.81.8-1.71.7-1.81.61.60.1
Right kidney weight0.31.21.7-1.31.2-1.11.11.11.1-1.21.2-1.10.90.90.1
Cocaine induced anxiety0.00.00.1-0.20.1-0.10.20.10.1-0.20.3-0.10.30.1-0.1
Post-drug Anxiety0.00.00.00.0-0.20.1-0.1-0.2-0.20.10.00.1-0.1-0.10.0
Baseline Anxiety0.10.10.20.4-0.30.3-0.3-0.3-0.30.3-0.30.3-0.4-0.20.2
Tail length4.818.820.7-4.44.5-4.44.44.54.5-4.54.5-4.64.54.5-2.1
Length with tail8.536.941.5-6.46.4-6.36.36.46.4-6.16.2-6.46.16.1-2.4
Length without tail6.721.726.1-5.15.0-5.04.95.05.0-4.64.7-4.94.64.5-1.5
Times rat made contact with spout0.50.50.8-0.90.7-0.70.80.70.7-0.70.8-0.70.70.7-0.8
Lifetime Intake2.22.63.41.8-1.61.7-1.7-1.6-1.61.5-1.81.6-1.7-1.71.0
Liver weight, left0.61.01.5-1.01.0-1.01.01.01.0-0.91.0-1.11.21.1-0.7
Liver weight, right1.52.63.6-1.61.7-1.71.71.71.7-1.91.6-1.71.81.6-0.5
Locomotor activity5.58.69.9-3.03.1-3.03.03.13.2-3.13.2-3.12.82.9-1.1
Locomotor testing distance4.27.59.2-2.73.0-2.82.83.03.0-2.82.8-2.92.72.8-1.0
Locomotor testing rearing0.10.20.5-0.00.4-0.20.20.50.5-0.20.3-0.40.40.5-0.7
Locomotion in novel chamber0.10.20.30.2-0.40.4-0.3-0.5-0.50.6-0.20.5-0.5-0.5-0.1
Locomotion in novel chamber post-restriction0.40.71.0-1.00.8-0.80.90.80.8-0.80.9-0.80.70.8-0.6
Fecal boli incidents, locomotor time 10.30.40.6-0.50.6-0.60.70.70.7-0.30.6-0.60.80.6-0.4
Change in fecal boli incidents, locomotor task0.00.00.00.1-0.00.1-0.1-0.0-0.00.1-0.20.00.0-0.00.1
Time >=10cm from walls, locomotor time 10.10.10.10.3-0.30.3-0.2-0.3-0.30.0-0.20.3-0.3-0.30.4
Bouts of movement, locomotor time 10.00.10.3-0.10.2-0.10.10.20.2-0.20.2-0.20.50.30.1
Total resting periods, locomotor time 10.00.00.2-0.00.1-0.10.10.10.2-0.10.1-0.20.50.20.1
Rest time, locomotor task time 10.50.61.50.9-0.80.9-0.8-0.8-0.81.2-0.80.8-0.2-0.70.3
Distance moved, locomotor task time 11.11.62.1-1.51.3-1.41.31.31.3-1.31.3-1.31.01.2-0.7
Vertical activity count, locomotor time 10.41.01.4-1.21.0-1.01.01.01.0-1.11.0-1.00.80.9-0.5
Time >=10cm from walls, locomotor time 21.01.51.8-1.31.3-1.31.31.31.3-1.01.3-1.31.31.2-0.7
Bouts of movement, locomotor time 20.00.00.00.20.00.0-0.10.00.10.1-0.1-0.0-0.2-0.10.1
Total resting periods, locomotor time 20.10.10.20.4-0.20.3-0.3-0.2-0.20.3-0.40.2-0.5-0.30.3
Rest time, locomotor task time 20.00.10.20.4-0.20.2-0.3-0.2-0.20.2-0.30.2-0.1-0.20.2
Distance moved, locomotor task time 21.01.21.8-1.31.1-1.11.21.01.0-1.01.1-1.11.11.0-0.7
Vertical activity count, locomotor time 20.00.10.2-0.40.2-0.20.30.20.2-0.30.2-0.20.20.1-0.3
Light reinforcement 10.41.01.2-1.11.1-1.11.01.01.0-1.11.0-1.00.90.9-0.0
Light reinforcement 20.20.32.50.1-0.20.2-0.4-0.3-0.3-0.2-0.40.3-0.5-0.51.6
Bone: marrow area0.00.10.2-0.10.4-0.30.20.40.4-0.40.2-0.40.40.4-0.3
Bone: maximum diameter0.40.81.00.8-0.91.0-0.9-0.9-0.91.0-1.00.9-1.0-1.00.4
Bone: maximum force0.61.01.3-1.11.1-1.11.11.11.1-1.00.8-1.11.01.0-0.3
Bone: maximum moment0.61.11.4-1.21.2-1.21.11.21.2-1.10.9-1.11.11.0-0.2
Mean time between licks in bursts0.82.02.71.4-1.41.5-1.5-1.4-1.41.4-1.41.4-1.7-1.50.8
Mean num. licks in bursts0.60.91.5-1.20.9-1.01.00.90.9-1.21.1-0.90.80.8-0.2
Cd content in liver0.10.10.20.2-0.30.4-0.3-0.3-0.30.2-0.30.4-0.4-0.40.2
Co content in liver1.21.42.01.4-1.21.2-1.2-1.2-1.21.4-1.31.2-1.0-1.0-0.0
Cu content in liver3.74.45.1-2.22.3-2.22.22.22.2-2.12.1-2.22.12.1-0.9
Fe content in liver1.31.53.4-1.01.1-1.11.21.21.2-0.81.3-1.21.31.4-1.8
K content in liver0.20.20.8-0.50.5-0.50.40.40.4-0.60.3-0.40.40.10.9
Mg content in liver1.41.45.80.8-0.90.8-1.0-1.0-1.00.6-1.21.1-1.1-1.42.4
Mn content in liver0.30.33.2-0.30.2-0.30.10.10.1-0.6-0.2-0.10.1-0.31.8
Na content in liver0.70.82.5-0.60.7-0.60.80.70.8-0.61.0-0.80.91.0-1.6
Rb content in liver1.11.36.8-0.40.8-0.70.90.90.9-0.51.0-0.91.21.3-2.6
Se content in liver0.10.10.5-0.40.2-0.20.20.20.2-0.20.1-0.20.10.10.7
Sr content in liver0.90.88.7-0.3-0.0-0.1-0.2-0.1-0.2-0.3-0.40.2-0.4-0.82.9
Zn content in liver1.92.12.6-1.61.6-1.51.51.51.5-1.61.4-1.51.41.3-0.0
Bone: minimum diameter0.61.01.61.1-0.91.0-1.1-0.9-0.91.0-1.31.0-1.1-1.00.8
Time in familiar zone, hab. session 11.41.32.31.5-1.21.3-1.2-1.1-1.11.5-1.01.1-0.9-0.8-0.7
Time in novel zone, hab. session 10.70.71.1-1.10.8-0.90.90.80.8-1.00.9-0.80.70.70.1
Total zone transitions, hab. session 10.60.91.7-1.21.0-1.00.90.90.9-1.30.6-0.80.70.51.1
Total locomotion distance, hab. session 10.30.40.6-0.80.7-0.70.70.60.6-0.80.6-0.60.60.50.6
Locomotion velocity, hab. session 10.30.50.8-0.90.7-0.70.70.60.6-0.90.6-0.60.60.50.6
Time in familiar zone, hab. session 20.70.71.21.0-0.80.9-0.9-0.8-0.81.1-0.90.8-0.8-0.80.2
Time in novel zone, hab. session 20.10.10.2-0.20.2-0.20.30.20.2-0.40.3-0.20.20.3-0.5
Total zone transitions, hab. session 20.20.32.3-0.60.3-0.40.30.30.2-0.6-0.0-0.20.0-0.21.5
Total locomotion distance, hab. session 20.30.40.8-0.90.7-0.70.70.60.6-0.80.6-0.60.60.40.6
Locomotion velocity, hab. session 20.20.30.7-0.80.6-0.60.60.50.5-0.70.5-0.50.50.30.7
Novel to familiar place preference ratio0.80.81.9-0.81.0-0.80.80.91.0-1.41.0-0.90.90.9-0.1
Novelty place preference0.80.82.0-0.80.9-0.80.80.90.9-1.41.0-0.90.90.9-0.2
Time in novel zone, NPP test1.01.12.2-0.81.1-1.00.91.11.1-1.51.2-1.11.11.1-0.4
Total zone transitions, NPP test2.23.25.2-2.31.9-1.91.81.81.8-2.21.5-1.71.51.11.7
Total locomotion distance, NPP test1.01.42.3-1.51.2-1.31.21.21.2-1.31.1-1.11.10.90.6
Locomotion velocity, NPP test1.11.52.6-1.61.3-1.41.31.21.2-1.51.1-1.21.10.90.7
Intraocular pressure1.11.74.4-0.91.2-1.01.11.21.2-0.81.4-1.31.31.5-2.1
Delta distance traveled before/after self-admin0.00.00.1-0.20.2-0.30.20.20.2-0.30.3-0.20.20.10.1
Delta ambulatory time before/after self-admin0.81.01.7-0.91.1-1.11.01.11.1-1.30.9-1.11.11.0-0.2
Parametrial fat weight0.81.92.7-1.61.5-1.51.51.41.4-1.61.5-1.41.11.20.2
Pavlov. Cond. lever latency4.35.56.1-2.22.3-2.32.42.42.4-2.32.3-2.42.42.5-2.0
Pavlov. Cond. magazine entry latency7.49.610.63.1-3.23.2-3.2-3.2-3.23.1-3.33.2-3.3-3.21.7
Pavlov. Cond. change in total contacts1.61.72.11.4-1.41.4-1.4-1.3-1.31.5-1.21.3-1.3-1.20.2
Pavlov. Cond. index score6.38.08.82.8-2.92.9-2.9-2.9-2.92.9-2.92.9-3.0-2.91.6
Pavlov. Cond. latency score6.17.88.52.8-2.82.9-2.9-2.9-2.82.8-2.92.9-2.9-2.91.8
Pavlov. Cond. lever contacts2.73.23.71.6-1.81.8-1.8-1.8-1.81.8-1.81.8-1.9-1.91.7
Pavlov. Cond. magazine entry number7.59.410.5-3.13.2-3.23.23.23.2-3.23.2-3.23.23.1-1.4
Pavlov. Cond. intertrial magazine entries0.40.50.7-0.60.7-0.70.60.80.8-0.50.7-0.80.90.8-0.4
Pavlov. Cond. lever-magazine prob. diff.5.77.07.82.6-2.72.8-2.7-2.7-2.72.8-2.72.7-2.8-2.71.5
Pavlov. Cond. response bias6.88.49.42.8-3.03.0-3.0-3.0-3.03.0-3.03.0-3.1-3.01.8
Pavlov. Cond. lever latency0.60.81.11.0-1.01.0-0.9-1.0-1.01.0-0.80.9-0.8-0.7-0.7
Pavlov. Cond. magazine entry latency0.20.31.80.3-0.30.3-0.4-0.3-0.40.3-0.50.4-0.4-0.61.4
Pavlov. Cond. change in total contacts2.03.24.0-1.92.0-1.91.82.02.0-1.71.8-1.91.71.70.0
Pavlov. Cond. index score0.20.31.1-0.60.6-0.60.40.50.5-0.40.4-0.50.40.21.0
Pavlov. Cond. latency score0.20.21.3-0.40.4-0.40.30.40.4-0.30.2-0.30.20.11.1
Pavlov. Cond. lever contacts0.91.21.5-1.21.2-1.21.11.21.2-1.21.0-1.11.00.90.4
Pavlov. Cond. magazine entry number0.30.31.4-0.40.4-0.40.50.40.4-0.40.5-0.50.60.7-1.2
Pavlov. Cond. intertrial magazine entries0.60.81.31.1-1.01.0-0.9-0.9-0.91.0-0.90.9-0.8-0.6-1.0
Pavlov. Cond. lever-magazine prob. diff.0.20.31.4-0.50.5-0.50.30.50.4-0.40.3-0.40.30.11.2
Pavlov. Cond. response bias0.10.21.0-0.40.4-0.40.30.40.4-0.30.2-0.30.20.11.0
Time in closed arm before self-admin0.60.81.1-0.81.0-1.01.01.01.0-0.81.0-1.00.70.9-0.5
Time in closed arm after self-admin0.20.20.30.3-0.50.4-0.4-0.5-0.50.5-0.40.5-0.4-0.50.1
Time in open arm before self-admin0.91.01.50.8-1.11.2-1.1-1.1-1.11.0-1.01.1-0.6-1.00.4
Time in open arm after self-admin0.20.20.30.5-0.40.5-0.5-0.4-0.40.0-0.50.4-0.4-0.40.4
Bone: periosteal estimation0.00.00.10.10.10.0-0.00.10.10.0-0.2-0.00.00.0-0.0
Bone: periosteal perimeter1.01.82.31.3-1.31.4-1.4-1.3-1.31.3-1.51.4-1.4-1.40.5
Bone: post-yield work0.00.00.1-0.10.1-0.10.10.10.1-0.2-0.1-0.1-0.0-0.00.1
Progressive ratio test 1 active lever presses0.00.00.10.2-0.10.1-0.2-0.1-0.1-0.2-0.20.1-0.2-0.10.2
Progressive ratio test 1 breakpoint0.00.00.10.2-0.10.2-0.2-0.1-0.1-0.2-0.30.1-0.2-0.10.2
Progressive ratio test 1 inactive lever presses0.40.61.00.8-0.70.8-0.8-0.7-0.70.9-1.00.8-0.9-0.80.4
Progressive ratio test 2 active lever presses2.32.73.31.6-1.71.8-1.7-1.7-1.71.7-1.81.7-1.7-1.70.8
Progressive ratio test 2 breakpoint2.42.73.31.6-1.71.8-1.7-1.7-1.71.7-1.81.7-1.7-1.70.8
Progressive ratio test 2 inactive lever presses2.54.15.12.0-2.02.1-2.1-2.0-2.02.3-2.12.1-2.2-2.11.0
Incentive Sensitization - Responses2.23.14.11.8-1.81.8-1.8-1.8-1.82.0-1.91.8-1.6-1.80.8
Incentive Sensitization - Breakpoint2.43.14.11.8-1.81.8-1.8-1.8-1.82.0-2.01.8-1.6-1.80.8
Sum of active levers in priming session hrs 5-60.00.00.1-0.1-0.00.1-0.0-0.0-0.0-0.0-0.0-0.00.30.1-0.2
Progressive ratio2.33.64.6-2.11.9-2.02.11.91.9-1.91.9-1.92.11.8-1.0
Food seeking constrained by brief footshock1.01.21.60.9-1.21.1-1.0-1.2-1.21.1-1.01.2-1.1-1.20.5
Seeking ratio, punishment vs. effort4.26.07.52.6-2.52.5-2.5-2.5-2.52.5-2.42.5-2.7-2.51.2
Retroperitoneal fat weight1.66.68.0-2.82.7-2.72.72.72.7-2.72.7-2.72.42.5-0.8
Reaction time number correct0.20.50.60.8-0.70.7-0.7-0.7-0.70.7-0.40.7-0.8-0.7-0.1
Reaction time mean minus median0.10.10.5-0.50.3-0.40.30.30.3-0.60.1-0.30.00.20.7
Reaction time mean minus median AUC0.10.30.8-0.60.6-0.70.60.60.6-0.90.4-0.60.40.50.5
Reaction time num false alarms0.30.40.70.8-0.60.7-0.7-0.6-0.50.6-0.80.6-0.6-0.4-0.3
Reaction time num false alarms AUC0.10.10.20.5-0.30.4-0.3-0.3-0.30.2-0.40.3-0.4-0.1-0.4
Reaction time trials correct on left0.20.50.60.8-0.70.7-0.7-0.7-0.70.7-0.40.7-0.8-0.7-0.1
Reaction time trials on left0.30.50.70.8-0.80.8-0.7-0.7-0.70.7-0.40.7-0.8-0.7-0.1
Reaction time mean0.00.00.0-0.10.1-0.00.10.10.1-0.20.1-0.1-0.10.2-0.2
Reaction time mean AUC0.00.00.0-0.00.00.00.00.00.1-0.2-0.0-0.0-0.20.1-0.2
Median of all reaction times0.00.00.20.1-0.10.2-0.1-0.0-0.00.0-0.10.0-0.20.1-0.4
Reaction time omissions0.20.31.90.4-0.40.5-0.3-0.3-0.30.4-0.10.3-0.30.0-1.4
Reaction time false alarm rate0.00.00.10.2-0.10.2-0.1-0.1-0.10.0-0.40.1-0.10.1-0.3
Reaction time premature initiation rate2.12.93.3-1.71.8-1.81.81.81.8-1.71.7-1.81.41.8-0.6
Reaction time premature initiations0.81.41.8-1.21.3-1.31.31.31.3-1.21.3-1.30.81.2-0.5
Std. dev. reaction times0.10.20.5-0.50.4-0.40.40.40.4-0.70.4-0.40.10.40.0
Reaction time trials completed0.30.50.70.8-0.80.8-0.7-0.7-0.70.7-0.40.7-0.8-0.7-0.1
Reaction time trials AUC0.30.70.90.9-0.90.9-0.9-0.9-0.80.9-0.50.9-0.9-0.8-0.1
Run reversals in cocaine runway, females0.90.91.30.9-1.11.0-1.0-1.1-1.11.0-0.81.0-1.1-0.90.4
Run reversals in cocaine runway, males1.01.01.4-1.11.0-1.11.11.01.0-0.91.0-1.01.20.9-0.5
Latency to leave start box in cocaine runway0.20.30.4-0.60.5-0.60.60.50.5-0.40.6-0.50.50.5-0.2
Latency to leave start box in cocaine runway, F0.70.81.0-1.01.0-1.01.01.01.0-0.91.0-0.90.70.8-0.4
Latency to leave start box in cocaine runway, M0.80.81.60.8-0.91.0-0.9-0.9-0.91.3-0.60.9-0.7-0.80.2
Std. dev. time between licks in bursts4.05.46.62.6-2.32.4-2.5-2.3-2.32.5-2.52.3-2.2-2.41.3
Total sessions with >9 infusions0.60.81.40.9-0.80.9-0.9-0.8-0.81.2-1.00.9-0.8-0.90.4
Short access day 1 total inactive lever presses3.74.86.02.4-2.12.2-2.4-2.1-2.12.4-2.42.2-2.3-2.21.2
Short access day 10 total inactive lever presses0.00.10.2-0.20.3-0.30.20.30.30.10.1-0.30.40.3-0.1
Short access day 1 total infusions2.93.94.72.1-2.02.0-2.1-2.0-2.02.1-2.22.0-1.9-2.01.1
Short access day 10 total infusions2.22.83.31.8-1.71.8-1.8-1.7-1.71.6-1.81.7-1.7-1.71.0
Short access total infusions3.24.15.02.2-2.12.1-2.2-2.1-2.01.9-2.22.1-2.1-2.11.1
Short access day 1 locomotion0.60.81.60.9-0.90.9-0.9-0.9-0.91.3-1.00.9-0.8-0.90.3
Short access day 10 total locomotion0.00.00.2-0.10.2-0.10.10.20.2-0.40.1-0.10.50.10.0
Short access total locomotion0.10.10.10.2-0.30.3-0.3-0.3-0.30.3-0.30.3-0.1-0.30.1
One hour access (0.3 mA shock)0.70.81.21.0-0.90.9-1.0-0.8-0.80.6-1.10.9-0.7-0.90.7
Compulsive drug intake0.50.60.80.9-0.90.8-0.8-0.8-0.90.7-0.80.8-0.6-0.80.5
One hour access (shock baseline)0.40.60.80.8-0.80.9-0.9-0.8-0.70.8-0.90.8-0.8-0.80.4
Social response proportion0.40.41.2-0.70.5-0.60.80.50.5-0.60.7-0.60.40.7-1.1
Social responses0.30.40.8-0.80.7-0.70.70.60.6-0.90.7-0.60.20.6-0.1
Social time0.40.50.80.6-0.70.7-0.7-0.7-0.70.8-0.70.7-0.9-0.70.7
Soleus weight3.811.113.0-3.53.6-3.63.53.53.5-3.43.3-3.53.53.2-0.5
Bone: stiffness0.10.20.3-0.50.5-0.50.50.50.5-0.50.3-0.50.40.5-0.2
Tibialis anterior weight0.00.00.1-0.20.2-0.10.10.20.20.0-0.0-0.10.10.00.2
Time to tail flick, vehicle, before self-admin1.81.93.4-1.31.4-1.41.51.41.4-1.21.3-1.41.91.4-0.8
Time to tail flick, vehicle, after self-admin0.20.20.4-0.40.5-0.60.60.40.4-0.50.6-0.4-0.00.3-0.3
Time to tail flick, test, before self-admin0.00.00.2-0.1-0.0-0.00.1-0.1-0.1-0.40.10.0-0.3-0.1-0.1
Time to tail flick, test, after self-admin0.20.20.30.5-0.40.5-0.4-0.4-0.40.6-0.30.5-0.3-0.50.0
Delta time to tail flick, vehicle, before/after SA0.50.51.40.7-0.70.6-0.7-0.7-0.70.6-0.60.7-1.2-0.80.4
Delta time to tail flick, test, before/after SA0.20.20.50.6-0.50.5-0.5-0.5-0.40.7-0.50.5-0.4-0.40.2
Tibia length5.916.321.4-4.64.4-4.44.34.34.3-4.43.9-4.23.93.60.4
Ambulatory time before self-admin0.60.91.71.1-1.00.9-1.0-1.0-1.01.3-0.80.9-1.0-0.90.4
Ambulatory time after self-admin0.00.00.10.3-0.1-0.0-0.1-0.1-0.10.1-0.10.1-0.2-0.10.2
Bone: tissue strength2.92.93.4-1.71.9-1.91.81.91.9-1.51.7-1.81.81.7-0.6
Total heroin consumption1.61.92.4-1.31.5-1.41.31.51.6-1.11.5-1.51.41.5-0.7
Bone: trabecular number0.50.91.01.0-1.01.0-1.0-1.0-1.00.7-1.01.0-1.0-0.90.3
Bone: trabecular spacing1.41.82.2-1.41.4-1.51.41.41.4-1.11.3-1.51.51.4-0.6
Bone: trabecular thickness0.10.10.4-0.40.2-0.20.20.20.2-0.50.2-0.20.10.10.6
Bone: trabecular tissue density0.40.50.8-0.90.8-0.80.80.70.7-0.90.7-0.70.60.60.3
Water consumed over 24 hours0.00.00.1-0.30.2-0.20.20.10.10.00.1-0.10.10.00.2
Number of responses in last shaping day0.40.40.80.8-0.60.6-0.7-0.6-0.60.8-0.90.6-0.5-0.50.4