Hub : Genes

Klhl11

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Klhl11 0.05 0.03 8.8e-04 0 0.01 0.01 0 2.2e-01 1.3e-02 5.7e-02 2.8e-01
2 Adipose mRNA stability Klhl11 0.06 0.04 3.0e-04 0.02 0 0 0.01 1.9e-03 1.2e-01 3.3e-01 2.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density0.20.40.50.7-0.6
Area under the delay curve0.00.00.10.20.3
BMI with tail1.03.55.2-2.31.3
BMI without tail2.78.49.3-3.02.7
Body weight1.88.012.9-3.61.8
Weight adjusted by age1.01.52.2-0.91.5
Bone surface0.10.10.20.0-0.4
Bone volume0.10.10.3-0.1-0.5
Breakpoint value in progressive ratio session0.30.40.40.70.5
Number of licking bursts0.40.60.60.8-0.8
Context. condit. distance diff. score2.12.64.4-0.82.1
Locomotion velocity, session 10.10.10.2-0.4-0.0
Locomotion distance, session 10.91.11.6-1.30.8
Locomotion velocity, session 20.20.20.50.7-0.1
Locomotion distance, session 20.00.10.1-0.3-0.2
Locomotion velocity, session 30.40.40.9-0.10.9
Locomotion distance, session 30.70.71.0-0.71.0
Stereotopy head waving bouts, day 31.31.51.91.1-1.4
Stereotopy head waving duration, day 30.40.50.90.2-1.0
Locomotion velocity, session 70.20.20.4-0.6-0.1
Locomotion distance, session 71.11.31.6-1.31.0
Stereotopy head waving bouts, day 72.02.23.31.8-1.1
Stereotopy head waving duration, day 72.73.24.32.1-1.5
Locomotion velocity, session 81.82.13.4-1.90.9
Locomotion distance, session 80.81.21.9-0.61.4
Degree of sensitization distance0.30.30.6-0.80.1
Degree of sensitization stereotypy1.61.73.01.7-0.7
Conditioned locomotion0.30.30.60.8-0.2
Cocaine response after cond. corrected0.10.10.10.3-0.4
Cocaine response after cond. not corrected0.50.50.90.4-1.0
Cocaine response before conditioning0.60.71.30.1-1.1
Saline control response0.10.20.3-0.3-0.5
Bone: connectivity density0.50.81.01.0-0.7
Bone: cortical apparent density4.05.46.12.2-2.5
Bone: cortical area0.81.21.80.8-1.3
Bone: cortical porosity0.90.91.8-0.21.3
Bone: cortical porosity1.11.22.0-0.61.4
Bone: cortical thickness2.13.43.92.0-1.7
Bone: cortical thickness3.44.06.92.6-1.0
Bone: cortical tissue density3.85.25.92.1-2.4
Condit. Reinf. active minus inactive responses0.20.20.40.6-0.1
Condit. Reinf. active-inactive response ratio0.40.40.90.90.1
Condit. Reinf. active responses0.30.30.50.7-0.4
Condit. Reinf. inactive responses0.20.30.60.1-0.8
Incentive salience index mean0.40.50.80.9-0.4
Condit. Reinf. lever presses0.20.40.50.4-0.7
Condit. Reinf. active minus inactive responses1.31.62.51.6-0.9
Condit. Reinf. active-inactive response ratio0.20.20.40.7-0.2
Condit. Reinf. active responses1.42.02.91.7-1.1
Condit. Reinf. inactive responses1.01.31.41.1-1.2
Condit. Reinf. lever presses0.20.30.50.70.3
Condit. Reinf. lever reinforcers received1.31.82.91.7-0.9
Conditioned reinforcement - actives1.11.92.5-1.11.6
Conditioned reinforcement - inactives0.30.50.5-0.6-0.7
Conditioned locomotion2.63.45.0-1.42.2
Patch foraging indifference point 0 sec0.40.71.31.1-0.2
Patch foraging indifference point AUC0.30.40.70.9-0.2
Delay disc. indifference point, 0s delay0.10.20.20.4-0.3
Delay disc. indifference point, 16s delay0.40.40.70.80.4
Delay disc. indifference point, 2s delay0.10.10.10.3-0.3
Delay disc. indifference point, 24s delay0.10.10.20.10.5
Delay disc. indifference point, 4s delay0.00.00.10.30.0
Delay disc. indifference point, 8s delay0.10.10.2-0.4-0.0
Indifference point function ln k0.30.60.80.6-0.9
Indifference point function log k0.30.60.80.6-0.9
Patch foraging total patch changes 0 sec0.20.40.70.9-0.1
Patch foraging total patch changes 12 sec1.21.52.41.5-0.8
Patch foraging total patch changes 18 sec0.20.30.40.40.7
Patch foraging total patch changes 24 sec0.20.40.70.80.1
Patch foraging total patch changes 6 sec0.10.20.30.60.3
Patch foraging time to switch 0 sec0.30.61.1-0.31.0
Patch foraging water rate 0 sec0.00.00.0-0.10.0
Patch foraging water rate 12 sec0.10.10.10.4-0.4
Patch foraging water rate 18 sec1.82.83.91.3-2.0
Patch foraging water rate 24 sec0.10.20.4-0.10.6
Patch foraging water rate 6 sec1.42.12.41.6-1.3
Seeking ratio, delayed vs. immediate footshock0.20.20.4-0.10.6
Distance traveled before self-admin0.91.12.0-0.51.4
Distance traveled after self-admin0.70.91.7-0.31.3
Extensor digitorum longus weight5.722.627.9-5.34.2
Bone: elastic displacement3.13.64.7-1.62.2
Bone: elastic work1.21.62.5-0.91.6
Bone: endosteal estimation2.14.66.4-2.51.7
Bone: endosteal perimeter0.81.82.9-1.70.8
Epididymis fat weight0.00.10.3-0.5-0.1
Delta time in closed arm before/after self-admin0.30.30.5-0.7-0.0
Delta time in open arm before/after self-admin0.10.10.10.1-0.4
Diff in mean of infusions in LGA sessions1.11.42.5-0.51.6
Delay discount exponential model param0.10.10.1-0.2-0.3
Extinction: sum of active levers before priming2.32.52.7-1.61.5
Active lever presses in extinction session 60.50.50.8-0.50.9
Bone: final force1.82.84.21.2-2.1
Bone: final moment1.32.23.50.9-1.9
Food consumed during 24 hour testing period0.00.00.0-0.1-0.1
Glucose1.01.61.8-1.21.3
Heart weight0.40.71.4-1.20.0
Delay discount hyperbolic model param0.00.10.1-0.1-0.3
Intermittent access intake day 1-15 change0.91.83.00.8-1.7
Intermittent access intake escalation1.22.54.10.9-2.0
Intermittent access intake escalation 20.50.61.10.2-1.0
Intermitt. access day 1 inactive lever presses0.00.00.00.1-0.2
Intermitt. access day 15 inactive lever presses0.30.61.00.4-1.0
Intermitt. access escalation Index0.00.00.00.2-0.1
Intermittent access day 1 total infusions0.10.20.2-0.40.5
Intermittent access day 15 total infusions0.50.81.30.6-1.1
Intermittent access terminal intake (last 3 days)0.40.50.90.4-0.9
Intermittent access total infusions0.10.10.10.1-0.3
Intermittent access day 1 locomotion0.10.10.2-0.30.4
Intermittent access day 15 total locomotion0.00.10.1-0.4-0.0
Intermittent access total locomotion0.10.10.10.3-0.3
Intermittent access standard deviation0.20.50.90.2-1.0
Left kidney weight0.31.61.71.2-1.3
Right kidney weight0.21.11.60.8-1.3
Cocaine induced anxiety0.40.50.8-0.90.5
Post-drug Anxiety1.01.11.3-1.10.9
Baseline Anxiety0.50.60.9-0.61.0
Tail length0.31.31.6-1.01.2
Length with tail0.41.73.0-1.70.6
Length without tail0.20.60.9-0.6-0.9
Times rat made contact with spout0.50.51.0-1.00.2
Lifetime Intake0.00.10.10.1-0.3
Liver weight, left0.10.20.20.4-0.4
Liver weight, right2.64.65.12.2-2.0
Locomotor activity0.50.81.21.1-0.6
Locomotor testing distance0.61.12.01.4-0.5
Locomotor testing rearing0.51.01.91.40.4
Locomotion in novel chamber1.01.22.21.5-0.5
Locomotion in novel chamber post-restriction0.20.30.6-0.80.2
Fecal boli incidents, locomotor time 10.00.10.1-0.30.1
Change in fecal boli incidents, locomotor task1.21.21.31.1-1.0
Time >=10cm from walls, locomotor time 11.92.02.31.3-1.5
Bouts of movement, locomotor time 10.20.20.4-0.6-0.0
Total resting periods, locomotor time 10.60.61.2-1.10.4
Rest time, locomotor task time 10.40.50.6-0.70.6
Distance moved, locomotor task time 10.20.30.30.4-0.6
Vertical activity count, locomotor time 10.10.30.5-0.70.4
Time >=10cm from walls, locomotor time 22.33.44.32.1-1.6
Bouts of movement, locomotor time 20.20.30.4-0.30.7
Total resting periods, locomotor time 20.20.40.5-0.50.7
Rest time, locomotor task time 20.81.02.0-1.40.4
Distance moved, locomotor task time 20.10.10.10.2-0.3
Vertical activity count, locomotor time 21.01.42.2-0.71.5
Light reinforcement 10.51.11.71.3-0.7
Light reinforcement 20.10.20.40.60.3
Bone: marrow area2.04.46.1-2.51.6
Bone: maximum diameter0.50.91.50.5-1.2
Bone: maximum force0.10.30.5-0.0-0.7
Bone: maximum moment0.10.10.2-0.3-0.5
Mean time between licks in bursts0.20.40.8-0.90.3
Mean num. licks in bursts1.42.12.9-1.71.2
Cd content in liver8.99.910.8-3.03.3
Co content in liver0.40.40.8-0.10.9
Cu content in liver0.80.91.41.2-0.7
Fe content in liver0.00.00.00.1-0.0
K content in liver8.48.110.73.3-2.3
Mg content in liver7.27.49.33.1-2.3
Mn content in liver14.616.217.34.2-3.9
Na content in liver0.20.20.30.1-0.6
Rb content in liver3.43.95.12.2-1.7
Se content in liver4.24.96.62.6-1.8
Sr content in liver0.10.10.20.4-0.0
Zn content in liver0.50.61.01.00.5
Bone: minimum diameter0.40.71.0-1.00.6
Time in familiar zone, hab. session 10.90.91.10.8-1.0
Time in novel zone, hab. session 10.50.50.7-0.40.9
Total zone transitions, hab. session 11.82.52.6-1.61.6
Total locomotion distance, hab. session 10.20.30.5-0.00.7
Locomotion velocity, hab. session 10.40.61.0-0.31.0
Time in familiar zone, hab. session 20.80.81.01.0-0.8
Time in novel zone, hab. session 20.10.10.2-0.20.4
Total zone transitions, hab. session 21.01.31.4-1.21.1
Total locomotion distance, hab. session 20.50.60.8-0.70.9
Locomotion velocity, hab. session 20.91.21.6-0.91.3
Novel to familiar place preference ratio0.40.40.6-0.40.8
Novelty place preference0.10.20.3-0.10.6
Time in novel zone, NPP test0.10.10.10.20.2
Total zone transitions, NPP test2.02.93.6-1.91.4
Total locomotion distance, NPP test0.60.81.0-1.00.7
Locomotion velocity, NPP test1.52.12.7-1.61.2
Intraocular pressure3.34.85.7-2.02.4
Delta distance traveled before/after self-admin0.30.30.50.7-0.4
Delta ambulatory time before/after self-admin0.00.00.1-0.0-0.3
Parametrial fat weight0.20.40.7-0.80.1
Pavlov. Cond. lever latency1.72.13.0-1.11.7
Pavlov. Cond. magazine entry latency3.95.05.72.4-2.1
Pavlov. Cond. change in total contacts4.75.06.32.5-1.9
Pavlov. Cond. index score3.34.14.71.9-2.2
Pavlov. Cond. latency score3.13.95.01.7-2.2
Pavlov. Cond. lever contacts1.72.12.91.1-1.7
Pavlov. Cond. magazine entry number5.97.58.0-2.82.6
Pavlov. Cond. intertrial magazine entries1.31.61.6-1.21.3
Pavlov. Cond. lever-magazine prob. diff.3.74.64.82.1-2.2
Pavlov. Cond. response bias4.55.56.82.6-2.1
Pavlov. Cond. lever latency0.20.30.5-0.7-0.2
Pavlov. Cond. magazine entry latency0.00.10.1-0.10.3
Pavlov. Cond. change in total contacts0.60.91.51.2-0.6
Pavlov. Cond. index score0.10.10.20.40.3
Pavlov. Cond. latency score0.10.10.10.30.3
Pavlov. Cond. lever contacts0.20.20.40.60.1
Pavlov. Cond. magazine entry number0.20.30.5-0.70.3
Pavlov. Cond. intertrial magazine entries0.50.71.10.5-1.1
Pavlov. Cond. lever-magazine prob. diff.0.10.10.30.50.1
Pavlov. Cond. response bias0.50.61.21.1-0.4
Time in closed arm before self-admin0.70.91.81.3-0.2
Time in closed arm after self-admin0.30.30.30.60.6
Time in open arm before self-admin0.10.10.2-0.50.0
Time in open arm after self-admin0.20.20.4-0.2-0.6
Bone: periosteal estimation0.20.30.7-0.80.1
Bone: periosteal perimeter0.10.20.5-0.70.2
Bone: post-yield work0.30.50.6-0.70.6
Progressive ratio test 1 active lever presses0.00.00.00.1-0.2
Progressive ratio test 1 breakpoint0.00.00.00.1-0.2
Progressive ratio test 1 inactive lever presses0.00.00.00.10.0
Progressive ratio test 2 active lever presses0.20.20.40.2-0.6
Progressive ratio test 2 breakpoint0.20.20.40.2-0.6
Progressive ratio test 2 inactive lever presses0.10.20.3-0.5-0.4
Incentive Sensitization - Responses0.10.10.2-0.1-0.5
Incentive Sensitization - Breakpoint0.10.10.2-0.1-0.4
Sum of active levers in priming session hrs 5-60.40.30.40.60.5
Progressive ratio0.00.00.00.1-0.0
Food seeking constrained by brief footshock0.20.20.30.6-0.4
Seeking ratio, punishment vs. effort0.00.10.10.2-0.3
Retroperitoneal fat weight0.10.40.6-0.40.8
Reaction time number correct0.20.40.6-0.80.3
Reaction time mean minus median0.00.00.0-0.2-0.1
Reaction time mean minus median AUC0.10.10.20.4-0.3
Reaction time num false alarms0.20.20.40.6-0.3
Reaction time num false alarms AUC0.20.40.40.7-0.6
Reaction time trials correct on left0.20.40.6-0.80.3
Reaction time trials on left0.10.30.5-0.70.2
Reaction time mean2.43.85.42.3-1.5
Reaction time mean AUC1.72.74.22.0-1.1
Median of all reaction times4.15.88.22.9-1.8
Reaction time omissions1.11.72.91.7-0.7
Reaction time false alarm rate0.40.50.70.8-0.5
Reaction time premature initiation rate0.10.10.10.30.3
Reaction time premature initiations0.10.20.3-0.30.5
Std. dev. reaction times0.40.70.80.9-0.7
Reaction time trials completed0.10.30.5-0.70.2
Reaction time trials AUC0.10.20.5-0.70.2
Run reversals in cocaine runway, females0.30.30.4-0.40.6
Run reversals in cocaine runway, males0.00.00.1-0.30.0
Latency to leave start box in cocaine runway0.70.81.3-1.10.5
Latency to leave start box in cocaine runway, F2.52.93.6-1.91.5
Latency to leave start box in cocaine runway, M1.21.11.21.0-1.1
Std. dev. time between licks in bursts0.10.10.2-0.10.4
Total sessions with >9 infusions0.00.00.10.00.3
Short access day 1 total inactive lever presses0.00.00.0-0.1-0.1
Short access day 10 total inactive lever presses0.30.70.8-0.70.9
Short access day 1 total infusions0.50.70.70.9-0.7
Short access day 10 total infusions0.00.10.1-0.3-0.2
Short access total infusions0.00.00.10.2-0.2
Short access day 1 locomotion0.20.30.60.8-0.0
Short access day 10 total locomotion0.20.40.80.3-0.9
Short access total locomotion0.00.00.10.0-0.3
One hour access (0.3 mA shock)0.10.20.3-0.50.2
Compulsive drug intake0.20.20.50.7-0.1
One hour access (shock baseline)0.20.30.5-0.70.3
Social response proportion1.41.62.5-0.91.6
Social responses0.30.30.70.20.8
Social time0.50.71.4-1.2-0.0
Soleus weight0.41.12.1-1.40.4
Bone: stiffness1.11.82.71.0-1.6
Tibialis anterior weight0.93.13.5-1.91.6
Time to tail flick, vehicle, before self-admin0.50.50.8-0.90.5
Time to tail flick, vehicle, after self-admin3.64.85.7-2.02.4
Time to tail flick, test, before self-admin0.20.20.3-0.20.6
Time to tail flick, test, after self-admin0.80.91.40.5-1.2
Delta time to tail flick, vehicle, before/after SA1.01.01.2-1.10.8
Delta time to tail flick, test, before/after SA0.80.81.00.8-1.0
Tibia length0.20.50.6-0.8-0.6
Ambulatory time before self-admin1.21.83.0-0.71.7
Ambulatory time after self-admin1.61.82.4-1.11.6
Bone: tissue strength0.50.50.9-1.0-0.1
Total heroin consumption0.50.61.21.1-0.3
Bone: trabecular number0.91.51.91.4-1.1
Bone: trabecular spacing0.91.11.9-1.40.6
Bone: trabecular thickness0.00.00.10.0-0.3
Bone: trabecular tissue density1.01.51.61.2-1.3
Water consumed over 24 hours0.40.61.10.0-1.1
Number of responses in last shaping day0.20.30.5-0.70.2