Klhdc8b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Klhdc8b	0.06	0.04	8.9e-04	0.02	0.02	0.02	0.02	1.4e-03	6.5e-03	1.3e-03	6.0e-03
2	Brain	gene expression	Klhdc8b	0.16	0.1	6.3e-08	0.08	0.08	0.08	0.08	5.6e-08	1.1e-07	8.2e-08	1.4e-07
3	Brain	isoform ratio	XM_039081332.1	0.03	0.03	9.3e-04	0.02	0.02	0.01	0.01	4.4e-03	6.0e-03	1.5e-02	1.6e-02
4	Adipose	gene expression	Klhdc8b	0.07	0.04	5.6e-09	0.05	0.06	0.05	0.05	2.1e-06	3.3e-07	5.3e-06	5.2e-06
5	Brain	alternative TSS	XM_039081332.1	0.04	0.03	8.7e-04	0.02	0.02	0.02	0.02	4.1e-03	2.3e-03	2.6e-03	6.0e-03
6	Brain	alternative TSS	XM_039081332.1	0.03	0.03	6.9e-04	0.03	0.03	0.02	0.03	1.3e-03	4.2e-04	2.7e-03	1.4e-03
7	NAcc	gene expression	Klhdc8b	0.13	0.07	5.2e-10	0.1	0.1	0.09	0.1	4.0e-12	1.5e-11	8.9e-11	6.7e-12
8	NAcc	isoform ratio	NM_001007685.1	0.03	0.02	4.2e-03	0.01	0.02	0.02	0.02	6.1e-02	2.2e-03	4.1e-03	3.9e-03
9	PL	gene expression	Klhdc8b	0.04	0.03	1.2e-05	0.06	0.05	0.06	0.05	9.9e-07	3.9e-06	8.5e-07	2.1e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	0.8	1.4	1.9	-0.4	-1.0	1.0	-1.2	-1.2	-1.3	-1.3	1.4	-1.3
Area under the delay curve	0.9	0.9	5.2	2.3	-0.4	0.4	-0.3	-0.4	-0.5	-0.8	1.0	-0.8
BMI with tail	2.1	6.9	61.1	-7.8	-0.3	0.3	-0.1	-0.1	0.0	-0.7	-0.4	-0.0
BMI without tail	3.4	6.9	55.9	-7.5	-1.1	1.1	-0.9	-0.9	-0.8	-1.2	0.2	-0.6
Body weight	2.4	10.1	86.7	-9.3	-0.7	0.7	-0.9	-0.6	-0.4	-0.6	-1.2	-0.0
Weight adjusted by age	3.8	4.3	34.3	-5.9	-0.1	0.1	0.5	0.5	0.6	1.1	-1.1	1.1
Bone surface	0.0	0.1	0.2	0.0	-0.0	0.0	-0.1	-0.1	-0.1	-0.5	0.3	-0.3
Bone volume	0.2	0.3	0.7	-0.9	-0.4	0.4	-0.5	-0.5	-0.5	-0.8	0.6	-0.6
Breakpoint value in progressive ratio session	0.3	0.3	0.7	0.8	-0.3	0.3	-0.6	-0.6	-0.6	-0.7	0.5	-0.6
Number of licking bursts	5.4	6.4	28.8	5.4	2.1	-2.1	1.9	1.9	1.9	1.8	-1.8	1.7
Context. condit. distance diff. score	0.4	0.5	4.4	-2.1	0.1	-0.1	0.2	0.2	0.2	0.3	-0.3	0.3
Locomotion velocity, session 1	0.2	0.2	0.3	-0.0	-0.3	0.3	-0.4	-0.4	-0.4	-0.5	0.5	-0.5
Locomotion distance, session 1	4.1	5.3	30.8	-5.5	-1.5	1.5	-1.4	-1.4	-1.4	-1.6	1.2	-1.4
Locomotion velocity, session 2	1.1	1.3	11.7	-3.4	-0.3	0.3	0.2	0.2	0.2	0.1	-0.1	0.1
Locomotion distance, session 2	4.9	6.8	46.4	-6.8	-1.7	1.7	-1.2	-1.2	-1.2	-1.4	1.3	-1.2
Locomotion velocity, session 3	3.6	4.2	20.0	-4.5	-1.5	1.5	-1.4	-1.4	-1.4	-1.7	1.5	-1.5
Locomotion distance, session 3	2.2	2.4	15.8	-4.0	-0.9	0.9	-0.6	-0.7	-0.7	-1.1	1.1	-0.9
Stereotopy head waving bouts, day 3	2.1	2.5	3.5	1.0	1.5	-1.5	1.5	1.6	1.6	1.8	-1.9	1.8
Stereotopy head waving duration, day 3	1.4	1.7	8.3	2.9	1.0	-1.0	0.8	0.9	0.9	1.0	-1.1	1.0
Locomotion velocity, session 7	1.6	1.8	2.4	1.0	-1.2	1.2	-1.3	-1.4	-1.4	-1.3	1.5	-1.5
Locomotion distance, session 7	0.5	0.6	1.2	0.9	-0.6	0.6	-0.5	-0.6	-0.6	-0.8	1.1	-0.9
Stereotopy head waving bouts, day 7	0.2	0.2	0.3	-0.2	-0.5	0.5	-0.4	-0.5	-0.5	-0.4	0.5	-0.4
Stereotopy head waving duration, day 7	0.3	0.3	0.5	-0.7	-0.6	0.6	-0.6	-0.6	-0.6	-0.6	0.5	-0.5
Locomotion velocity, session 8	2.1	2.5	11.2	-3.3	-1.2	1.2	-1.1	-1.1	-1.1	-1.4	1.0	-1.2
Locomotion distance, session 8	8.7	12.8	77.5	-8.8	-2.5	2.5	-2.0	-2.1	-2.0	-2.2	2.0	-2.0
Degree of sensitization distance	2.8	2.8	24.8	5.0	0.3	-0.3	-0.1	-0.1	-0.1	0.1	-0.2	-0.1
Degree of sensitization stereotypy	1.0	1.1	1.4	0.2	-1.0	1.0	-1.1	-1.1	-1.1	-1.0	1.2	-1.2
Conditioned locomotion	3.2	3.8	33.2	5.8	0.3	-0.3	0.2	0.1	0.0	-0.2	0.7	-0.4
Cocaine response after cond. corrected	2.0	2.3	3.5	-0.9	1.4	-1.4	1.4	1.5	1.5	1.6	-1.9	1.7
Cocaine response after cond. not corrected	2.4	2.6	18.3	-4.3	0.4	-0.4	0.6	0.6	0.7	0.9	-1.3	1.1
Cocaine response before conditioning	6.2	7.5	46.8	-6.8	-1.9	1.9	-1.6	-1.6	-1.6	-1.5	1.3	-1.3
Saline control response	3.2	4.2	5.5	-2.3	-2.1	2.1	-2.2	-2.2	-2.2	-1.7	1.9	-1.8
Bone: connectivity density	1.2	1.9	3.2	0.9	-1.2	1.2	-1.3	-1.4	-1.5	-1.4	1.8	-1.5
Bone: cortical apparent density	0.1	0.2	1.0	1.0	-0.2	0.2	-0.2	-0.2	-0.3	-0.2	0.5	-0.3
Bone: cortical area	2.8	4.2	4.7	1.9	2.0	-2.0	2.1	2.1	2.1	2.0	-2.2	2.0
Bone: cortical porosity	2.2	2.4	6.8	2.6	-1.1	1.1	-1.3	-1.4	-1.4	-1.2	1.6	-1.5
Bone: cortical porosity	2.0	2.2	3.1	1.8	-1.3	1.3	-1.4	-1.4	-1.5	-1.2	1.8	-1.5
Bone: cortical thickness	2.9	4.7	6.7	0.9	2.2	-2.2	2.2	2.2	2.3	2.2	-2.6	2.3
Bone: cortical thickness	0.4	0.5	3.0	1.7	0.5	-0.5	0.4	0.4	0.4	0.4	-0.4	0.3
Bone: cortical tissue density	0.2	0.2	0.7	0.8	-0.3	0.3	-0.3	-0.4	-0.4	-0.3	0.6	-0.4
Condit. Reinf. active minus inactive responses	5.0	5.7	40.0	6.3	1.6	-1.6	1.0	1.0	1.0	1.1	-1.0	0.9
Condit. Reinf. active-inactive response ratio	4.6	5.0	27.7	5.3	1.8	-1.8	1.3	1.4	1.4	1.5	-1.5	1.3
Condit. Reinf. active responses	2.7	3.3	22.3	4.7	1.3	-1.3	0.9	0.9	0.9	0.9	-0.8	0.7
Condit. Reinf. inactive responses	0.3	0.4	2.9	-1.7	-0.4	0.4	-0.2	-0.2	-0.2	-0.1	0.4	-0.4
Incentive salience index mean	3.5	4.3	31.7	5.6	1.3	-1.3	0.9	0.9	0.9	0.7	-0.7	0.5
Condit. Reinf. lever presses	1.5	2.0	14.4	3.8	1.0	-1.0	0.8	0.7	0.7	0.3	-0.3	0.2
Condit. Reinf. active minus inactive responses	0.0	0.0	0.1	-0.4	-0.0	0.0	-0.2	-0.2	-0.1	-0.3	-0.2	-0.2
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.4	-0.6	0.3	-0.3	0.2	0.2	0.3	0.0	-0.6	0.2
Condit. Reinf. active responses	0.1	0.2	1.3	1.2	0.0	-0.0	-0.2	-0.2	-0.1	-0.2	-0.2	-0.3
Condit. Reinf. inactive responses	0.4	0.5	4.7	2.2	0.0	-0.0	-0.0	-0.0	-0.1	0.0	0.1	-0.2
Condit. Reinf. lever presses	0.1	0.1	0.2	-0.3	-0.3	0.3	-0.4	-0.3	-0.3	-0.4	-0.2	-0.5
Condit. Reinf. lever reinforcers received	0.3	0.4	2.9	1.7	0.1	-0.1	-0.2	-0.2	-0.1	-0.2	-0.2	-0.3
Conditioned reinforcement - actives	0.2	0.2	1.0	-1.0	-0.5	0.5	-0.2	-0.2	-0.2	0.2	0.3	-0.0
Conditioned reinforcement - inactives	5.5	6.2	18.9	4.3	2.2	-2.2	2.2	2.2	2.2	2.4	-2.0	2.0
Conditioned locomotion	1.0	1.2	5.0	-2.2	-0.9	0.9	-0.8	-0.8	-0.9	-0.8	1.2	-0.7
Patch foraging indifference point 0 sec	2.7	4.3	13.2	-3.6	-2.0	2.0	-2.0	-1.9	-1.9	-1.5	1.5	-1.5
Patch foraging indifference point AUC	1.4	1.6	5.5	2.3	-0.4	0.4	-1.1	-1.1	-1.1	-1.5	1.2	-1.3
Delay disc. indifference point, 0s delay	3.5	3.9	31.4	5.6	1.2	-1.2	0.2	0.2	0.2	-0.3	0.1	-0.2
Delay disc. indifference point, 16s delay	1.6	1.6	13.3	3.6	0.0	-0.0	-0.1	-0.2	-0.2	-0.5	0.6	-0.6
Delay disc. indifference point, 2s delay	0.4	0.4	3.7	1.9	0.3	-0.3	0.0	-0.0	-0.0	-0.3	0.3	-0.2
Delay disc. indifference point, 24s delay	0.3	0.3	1.6	1.3	-0.2	0.2	-0.2	-0.3	-0.3	-0.5	0.7	-0.5
Delay disc. indifference point, 4s delay	4.9	5.2	44.1	6.6	0.9	-0.9	0.6	0.5	0.5	-0.0	0.0	-0.0
Delay disc. indifference point, 8s delay	1.3	1.3	5.8	-2.4	-1.1	1.1	-0.6	-0.7	-0.7	-0.7	1.2	-0.7
Indifference point function ln k	4.1	5.7	50.7	-7.1	-0.6	0.6	0.1	0.1	0.1	-0.1	0.1	0.2
Indifference point function log k	4.1	5.7	50.7	-7.1	-0.6	0.6	0.1	0.1	0.1	-0.1	0.1	0.2
Patch foraging total patch changes 0 sec	2.2	3.5	14.3	-3.8	-1.7	1.7	-1.6	-1.6	-1.6	-1.0	1.1	-1.1
Patch foraging total patch changes 12 sec	0.3	0.4	0.7	-0.5	-0.5	0.5	-0.8	-0.8	-0.8	-0.6	0.5	-0.6
Patch foraging total patch changes 18 sec	1.8	2.3	6.8	2.6	-1.0	1.0	-1.6	-1.5	-1.5	-1.2	1.2	-1.3
Patch foraging total patch changes 24 sec	1.0	1.2	8.0	-2.8	-0.6	0.6	-0.8	-0.7	-0.7	-0.5	0.2	-0.4
Patch foraging total patch changes 6 sec	1.3	2.0	2.7	0.3	-1.1	1.1	-1.6	-1.6	-1.6	-1.6	1.7	-1.5
Patch foraging time to switch 0 sec	2.0	3.1	10.4	3.2	1.6	-1.6	1.5	1.5	1.5	1.5	-1.4	1.4
Patch foraging water rate 0 sec	0.1	0.2	1.1	1.1	-0.3	0.3	-0.3	-0.3	-0.3	-0.0	0.1	-0.2
Patch foraging water rate 12 sec	0.1	0.1	0.7	-0.8	-0.4	0.4	-0.2	-0.2	-0.2	-0.2	0.0	-0.3
Patch foraging water rate 18 sec	0.5	0.6	1.6	-1.2	0.5	-0.5	0.8	0.8	0.8	0.6	-0.9	0.6
Patch foraging water rate 24 sec	0.3	0.4	2.6	-1.6	-0.4	0.4	-0.2	-0.2	-0.1	0.1	-0.2	0.1
Patch foraging water rate 6 sec	0.5	0.7	3.9	-2.0	-0.6	0.6	-0.6	-0.6	-0.6	-0.7	0.5	-0.5
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	1.3	-1.1	-0.4	0.4	-0.3	-0.3	-0.4	-0.6	0.9	-0.5
Distance traveled before self-admin	0.9	1.0	1.4	-0.9	0.7	-0.7	1.0	1.0	1.0	1.2	-1.1	1.2
Distance traveled after self-admin	1.0	1.1	3.8	1.9	1.0	-1.0	0.9	0.9	0.8	0.7	-0.7	0.8
Extensor digitorum longus weight	0.3	1.2	1.5	-0.0	1.0	-1.0	1.2	1.2	1.2	1.2	-1.1	1.2
Bone: elastic displacement	0.8	0.9	1.2	-0.5	1.0	-1.0	0.9	1.0	1.0	1.0	-1.1	1.1
Bone: elastic work	0.6	0.8	1.3	-0.5	1.0	-1.0	0.8	0.9	0.9	0.7	-1.2	0.8
Bone: endosteal estimation	0.7	1.5	8.7	3.0	-0.5	0.5	-0.8	-0.8	-0.8	-0.8	0.8	-0.9
Bone: endosteal perimeter	0.1	0.2	1.3	1.1	0.0	-0.0	0.3	0.2	0.2	0.0	0.2	-0.1
Epididymis fat weight	0.1	0.2	1.4	-1.2	-0.0	0.0	0.0	0.0	0.1	-0.0	-0.3	0.0
Delta time in closed arm before/after self-admin	1.6	1.5	12.5	3.5	0.7	-0.7	0.2	0.1	0.1	-0.3	0.3	-0.2
Delta time in open arm before/after self-admin	0.1	0.1	0.2	0.4	-0.2	0.2	-0.4	-0.4	-0.4	-0.4	0.3	-0.4
Diff in mean of infusions in LGA sessions	2.0	2.2	3.4	-0.4	1.2	-1.2	1.5	1.5	1.6	1.8	-1.8	1.7
Delay discount exponential model param	0.5	0.6	3.1	-1.8	0.4	-0.4	0.2	0.3	0.3	0.6	-0.9	0.6
Extinction: sum of active levers before priming	1.8	1.8	5.9	-2.4	-1.3	1.3	-1.1	-1.1	-1.1	-0.9	1.0	-1.0
Active lever presses in extinction session 6	1.7	1.7	7.0	2.6	-0.3	0.3	-1.0	-1.0	-1.0	-1.4	1.1	-1.2
Bone: final force	1.3	2.0	7.1	2.7	1.3	-1.3	1.0	1.1	1.1	1.0	-1.6	1.0
Bone: final moment	1.1	1.8	3.1	1.7	1.4	-1.4	1.1	1.2	1.3	1.1	-1.8	1.1
Food consumed during 24 hour testing period	1.1	1.3	10.9	-3.3	-0.6	0.6	-0.4	-0.4	-0.3	-0.1	-0.1	-0.1
Glucose	1.2	1.8	2.6	0.7	-1.2	1.2	-1.4	-1.5	-1.4	-1.5	1.4	-1.6
Heart weight	2.4	3.4	24.4	-4.9	-0.2	0.2	0.4	0.5	0.6	1.2	-1.5	1.1
Delay discount hyperbolic model param	0.8	0.8	5.3	-2.3	0.3	-0.3	0.2	0.3	0.3	0.6	-0.9	0.7
Intermittent access intake day 1-15 change	2.9	2.9	4.3	1.2	1.5	-1.5	1.8	1.8	1.8	2.1	-1.7	1.8
Intermittent access intake escalation	2.3	2.3	3.3	0.5	1.5	-1.5	1.6	1.6	1.6	1.8	-1.5	1.6
Intermittent access intake escalation 2	3.0	2.9	3.9	-1.4	1.6	-1.6	1.7	1.7	1.7	1.9	-1.8	2.0
Intermitt. access day 1 inactive lever presses	1.6	1.7	14.7	3.8	0.4	-0.4	0.2	0.2	0.2	0.3	-0.2	0.0
Intermitt. access day 15 inactive lever presses	6.0	6.6	33.8	5.8	2.0	-2.0	1.8	1.8	1.8	1.6	-1.6	1.5
Intermitt. access escalation Index	0.4	0.4	0.9	-0.6	-0.3	0.3	-0.5	-0.5	-0.6	-1.0	0.7	-0.5
Intermittent access day 1 total infusions	0.8	0.9	8.1	2.9	0.1	-0.1	-0.1	-0.1	-0.1	-0.0	0.2	-0.3
Intermittent access day 15 total infusions	2.2	2.5	15.9	4.0	1.1	-1.1	0.9	0.9	0.9	1.1	-0.7	0.6
Intermittent access terminal intake (last 3 days)	3.0	3.3	26.3	5.1	0.9	-0.9	0.5	0.5	0.5	0.7	-0.4	0.2
Intermittent access total infusions	1.9	2.1	17.2	4.1	0.6	-0.6	0.4	0.4	0.4	0.6	-0.2	0.0
Intermittent access day 1 locomotion	1.3	1.4	12.1	3.5	0.2	-0.2	-0.1	-0.1	-0.1	-0.2	0.3	-0.5
Intermittent access day 15 total locomotion	0.2	0.3	0.9	0.6	-0.2	0.2	-0.3	-0.4	-0.4	-0.5	0.9	-0.6
Intermittent access total locomotion	0.6	0.7	3.9	2.0	-0.2	0.2	-0.3	-0.4	-0.5	-0.6	1.0	-0.7
Intermittent access standard deviation	5.4	5.7	17.8	4.2	2.1	-2.1	1.9	1.9	2.0	2.3	-2.2	1.9
Left kidney weight	4.6	13.0	78.7	-8.9	-2.4	2.4	-2.2	-2.2	-2.1	-2.5	1.7	-1.9
Right kidney weight	2.5	7.1	29.0	-5.4	-2.2	2.2	-2.0	-2.0	-2.0	-2.4	1.9	-2.0
Cocaine induced anxiety	2.0	2.3	15.7	-4.0	0.4	-0.4	0.7	0.7	0.7	1.0	-0.9	1.1
Post-drug Anxiety	0.4	0.4	1.6	1.3	0.4	-0.4	0.5	0.5	0.5	0.6	-0.5	0.5
Baseline Anxiety	0.2	0.2	0.5	0.2	-0.7	0.7	-0.2	-0.3	-0.3	-0.1	0.5	-0.4
Tail length	1.5	4.6	24.6	-5.0	-1.7	1.7	-1.9	-1.7	-1.6	-1.0	0.2	-1.0
Length with tail	1.4	5.2	33.9	-5.8	-1.4	1.4	-1.8	-1.5	-1.4	-0.8	-0.5	-0.7
Length without tail	0.3	0.8	5.3	-2.3	-0.3	0.3	-0.7	-0.5	-0.4	0.0	-0.8	-0.0
Times rat made contact with spout	0.7	0.8	6.2	2.5	0.5	-0.5	0.2	0.3	0.3	0.4	-0.6	0.3
Lifetime Intake	1.1	1.2	10.7	3.3	0.3	-0.3	0.1	0.1	0.1	0.3	0.2	-0.2
Liver weight, left	2.2	3.5	21.5	4.6	-0.7	0.7	-1.2	-1.2	-1.3	-1.1	1.3	-1.3
Liver weight, right	2.1	3.5	5.4	-2.3	-1.8	1.8	-1.9	-1.9	-1.9	-1.7	1.5	-1.8
Locomotor activity	7.8	12.4	91.7	-9.6	-2.3	2.3	-1.8	-1.6	-1.5	-0.8	0.4	-0.8
Locomotor testing distance	8.8	14.6	107.5	-10.4	-2.4	2.4	-1.9	-1.8	-1.7	-1.0	0.7	-0.9
Locomotor testing rearing	0.4	0.6	5.2	-2.3	-0.2	0.2	-0.1	-0.1	-0.1	0.3	-0.1	0.3
Locomotion in novel chamber	1.4	1.7	4.7	2.2	1.5	-1.5	1.1	1.1	1.1	0.8	-1.0	1.0
Locomotion in novel chamber post-restriction	0.9	1.1	1.3	-1.1	-1.0	1.0	-1.1	-1.1	-1.1	-1.0	0.9	-1.0
Fecal boli incidents, locomotor time 1	2.0	2.2	18.6	-4.3	-0.5	0.5	-0.3	-0.2	-0.2	0.2	-0.3	0.2
Change in fecal boli incidents, locomotor task	0.7	0.6	4.1	2.0	-0.4	0.4	-0.3	-0.4	-0.4	-0.5	0.6	-0.5
Time >=10cm from walls, locomotor time 1	1.7	1.8	7.7	-2.8	-1.2	1.2	-0.9	-0.9	-0.9	-0.8	1.1	-0.9
Bouts of movement, locomotor time 1	0.6	0.6	4.8	2.2	0.5	-0.5	0.1	0.2	0.2	0.1	-0.3	0.0
Total resting periods, locomotor time 1	0.5	0.5	4.4	2.1	0.3	-0.3	0.1	0.1	0.1	0.1	-0.2	0.0
Rest time, locomotor task time 1	2.6	2.8	24.9	5.0	0.5	-0.5	0.2	0.2	0.1	-0.2	0.2	-0.2
Distance moved, locomotor task time 1	3.6	3.9	34.0	-5.8	-0.6	0.6	-0.1	-0.0	-0.0	0.5	-0.5	0.5
Vertical activity count, locomotor time 1	6.0	6.3	51.3	-7.2	-1.4	1.4	-0.7	-0.6	-0.6	0.0	0.0	-0.1
Time >=10cm from walls, locomotor time 2	0.8	0.8	4.8	-2.2	-0.5	0.5	-0.7	-0.7	-0.6	-0.4	0.2	-0.5
Bouts of movement, locomotor time 2	3.0	3.3	21.4	4.6	1.3	-1.3	1.0	1.0	1.0	0.8	-0.8	0.7
Total resting periods, locomotor time 2	3.0	3.2	21.6	4.6	1.2	-1.2	1.0	1.0	0.9	0.7	-0.7	0.6
Rest time, locomotor task time 2	2.9	3.3	29.1	5.4	0.4	-0.4	-0.0	-0.0	-0.0	-0.4	0.2	-0.3
Distance moved, locomotor task time 2	4.9	5.7	49.2	-7.0	-0.9	0.9	-0.2	-0.2	-0.1	0.5	-0.3	0.4
Vertical activity count, locomotor time 2	6.5	7.1	59.8	-7.7	-1.3	1.3	-0.5	-0.5	-0.5	0.1	0.2	-0.0
Light reinforcement 1	0.1	0.1	0.5	-0.7	-0.1	0.1	-0.4	-0.3	-0.3	-0.5	-0.0	-0.3
Light reinforcement 2	1.3	1.8	9.5	3.1	-0.2	0.2	-0.7	-0.8	-0.7	-1.5	1.0	-1.3
Bone: marrow area	0.6	1.3	6.8	2.6	-0.6	0.6	-0.8	-0.8	-0.8	-0.8	0.9	-1.0
Bone: maximum diameter	1.6	2.9	6.0	2.4	1.6	-1.6	1.7	1.7	1.7	1.5	-1.6	1.4
Bone: maximum force	1.1	1.8	12.4	3.5	1.0	-1.0	0.5	0.6	0.6	0.5	-1.0	0.4
Bone: maximum moment	0.7	1.3	6.1	2.5	1.0	-1.0	0.6	0.7	0.7	0.6	-1.1	0.6
Mean time between licks in bursts	0.8	1.1	7.2	2.7	0.7	-0.7	0.7	0.6	0.6	0.4	-0.2	0.3
Mean num. licks in bursts	3.7	4.5	14.0	-3.7	-1.9	1.9	-1.9	-1.9	-1.9	-1.8	1.7	-1.7
Cd content in liver	3.0	3.3	22.1	4.7	1.1	-1.1	0.5	0.7	0.7	1.1	-1.2	0.9
Co content in liver	1.1	1.3	2.4	1.5	1.0	-1.0	1.1	1.1	1.1	1.0	-1.1	1.0
Cu content in liver	1.2	1.5	3.1	1.8	-1.0	1.0	-1.4	-1.3	-1.3	-1.0	0.7	-1.2
Fe content in liver	5.0	6.0	48.4	7.0	1.1	-1.1	0.5	0.6	0.6	1.1	-1.0	0.7
K content in liver	2.3	2.3	12.1	-3.5	-1.2	1.2	-1.1	-1.0	-1.0	-1.2	0.6	-1.0
Mg content in liver	2.3	2.3	16.2	-4.0	-1.0	1.0	-0.7	-0.7	-0.6	-1.0	0.6	-0.7
Mn content in liver	2.8	3.2	6.8	-2.6	-1.7	1.7	-1.6	-1.6	-1.6	-1.7	1.5	-1.6
Na content in liver	2.2	2.3	17.2	4.2	-0.4	0.4	-0.8	-0.7	-0.8	-0.4	0.6	-0.8
Rb content in liver	7.2	8.9	64.4	8.0	1.7	-1.7	1.0	1.1	1.1	1.7	-1.5	1.2
Se content in liver	1.0	1.2	10.4	-3.2	-0.4	0.4	-0.2	-0.2	-0.2	-0.4	0.0	-0.2
Sr content in liver	2.9	2.7	20.5	-4.5	-0.8	0.8	-0.5	-0.5	-0.5	-0.8	0.5	-0.6
Zn content in liver	2.0	2.3	11.0	-3.3	-1.1	1.1	-1.4	-1.3	-1.2	-1.1	0.5	-0.9
Bone: minimum diameter	0.2	0.4	1.2	-1.1	0.4	-0.4	0.7	0.6	0.6	0.5	-0.4	0.6
Time in familiar zone, hab. session 1	9.2	8.6	59.4	7.7	1.7	-1.7	1.5	1.5	1.5	1.5	-1.1	1.2
Time in novel zone, hab. session 1	1.7	1.6	12.8	-3.6	-0.6	0.6	-0.6	-0.5	-0.5	-0.5	0.3	-0.4
Total zone transitions, hab. session 1	5.8	8.2	52.3	-7.2	-1.8	1.8	-1.6	-1.6	-1.5	-1.8	1.4	-1.4
Total locomotion distance, hab. session 1	1.7	2.5	15.3	-3.9	-1.0	1.0	-0.9	-0.9	-0.9	-1.0	0.8	-0.8
Locomotion velocity, hab. session 1	2.0	2.9	14.5	-3.8	-1.2	1.2	-1.2	-1.2	-1.2	-1.3	1.1	-1.1
Time in familiar zone, hab. session 2	4.9	5.1	28.0	5.3	1.7	-1.7	1.6	1.5	1.5	1.4	-1.3	1.2
Time in novel zone, hab. session 2	1.8	1.8	10.1	-3.2	-1.0	1.0	-0.9	-0.9	-0.9	-0.7	0.9	-0.6
Total zone transitions, hab. session 2	8.2	10.6	90.0	-9.5	-1.1	1.1	-0.6	-0.7	-0.6	-1.0	0.5	-0.3
Total locomotion distance, hab. session 2	2.7	3.6	25.4	-5.0	-1.0	1.0	-0.9	-0.9	-0.9	-1.1	0.7	-0.7
Locomotion velocity, hab. session 2	3.0	4.1	28.5	-5.3	-1.1	1.1	-1.0	-1.0	-1.0	-1.2	0.8	-0.8
Novel to familiar place preference ratio	10.2	10.5	23.0	-4.8	-3.2	3.2	-3.0	-3.0	-3.0	-2.6	3.0	-2.8
Novelty place preference	11.0	11.2	21.3	-4.6	-3.4	3.4	-3.2	-3.2	-3.2	-2.7	3.1	-2.9
Time in novel zone, NPP test	9.1	9.4	17.5	-4.2	-3.1	3.1	-2.9	-2.9	-3.0	-2.4	2.8	-2.7
Total zone transitions, NPP test	15.8	22.6	151.3	-12.3	-2.9	2.9	-2.5	-2.5	-2.4	-2.8	2.0	-2.2
Total locomotion distance, NPP test	6.3	8.6	65.2	-8.1	-1.5	1.5	-1.3	-1.3	-1.2	-1.2	0.8	-0.9
Locomotion velocity, NPP test	7.2	10.2	72.3	-8.5	-1.8	1.8	-1.6	-1.6	-1.6	-1.5	1.2	-1.3
Intraocular pressure	0.6	0.8	1.4	1.2	-0.9	0.9	-1.1	-1.0	-1.1	-0.3	0.7	-0.7
Delta distance traveled before/after self-admin	0.4	0.4	2.9	1.7	0.0	-0.0	-0.3	-0.3	-0.3	-0.5	0.4	-0.4
Delta ambulatory time before/after self-admin	0.4	0.5	1.6	1.3	-0.3	0.3	-0.7	-0.7	-0.6	-0.8	0.5	-0.7
Parametrial fat weight	0.3	0.7	1.1	-0.2	-0.6	0.6	-1.0	-1.0	-0.9	-1.1	0.6	-0.9
Pavlov. Cond. lever latency	1.2	1.6	3.4	-1.9	-1.2	1.2	-1.5	-1.4	-1.4	-0.8	0.6	-0.8
Pavlov. Cond. magazine entry latency	2.9	3.7	5.3	1.9	2.0	-2.0	2.3	2.2	2.1	1.7	-1.3	1.7
Pavlov. Cond. change in total contacts	10.1	10.8	74.2	8.6	2.2	-2.2	1.7	1.7	1.6	1.3	-1.2	1.2
Pavlov. Cond. index score	4.3	5.4	17.9	4.2	2.1	-2.1	2.3	2.2	2.1	1.7	-1.3	1.6
Pavlov. Cond. latency score	2.9	3.7	11.2	3.3	1.8	-1.8	2.0	1.9	1.8	1.3	-1.0	1.3
Pavlov. Cond. lever contacts	1.3	1.6	5.7	2.4	1.2	-1.2	1.3	1.2	1.2	0.6	-0.6	0.7
Pavlov. Cond. magazine entry number	4.0	5.0	15.2	-3.9	-2.1	2.1	-2.3	-2.1	-2.1	-1.7	1.2	-1.6
Pavlov. Cond. intertrial magazine entries	0.5	0.7	3.1	-1.8	-0.7	0.7	-0.7	-0.7	-0.7	-0.4	0.4	-0.5
Pavlov. Cond. lever-magazine prob. diff.	5.3	6.5	18.4	4.3	2.4	-2.4	2.6	2.5	2.4	2.0	-1.7	1.9
Pavlov. Cond. response bias	4.5	5.5	12.7	3.6	2.3	-2.3	2.5	2.4	2.3	1.8	-1.5	1.8
Pavlov. Cond. lever latency	0.0	0.0	0.1	0.3	0.2	-0.2	0.1	0.1	0.1	0.3	0.1	0.3
Pavlov. Cond. magazine entry latency	0.8	0.9	6.2	2.5	0.6	-0.6	0.5	0.5	0.5	0.1	-0.4	0.0
Pavlov. Cond. change in total contacts	0.4	0.5	3.8	1.9	0.3	-0.3	-0.0	0.1	0.1	-0.1	-0.6	-0.1
Pavlov. Cond. index score	0.3	0.3	1.7	1.3	0.4	-0.4	0.4	0.4	0.5	0.1	-0.6	0.1
Pavlov. Cond. latency score	0.1	0.1	0.3	0.5	0.3	-0.3	0.4	0.4	0.4	0.1	-0.5	0.1
Pavlov. Cond. lever contacts	0.2	0.3	0.6	0.1	-0.6	0.6	-0.6	-0.6	-0.6	-0.7	0.3	-0.8
Pavlov. Cond. magazine entry number	3.7	4.6	36.6	-6.1	-1.1	1.1	-0.8	-0.8	-0.8	-0.3	0.5	-0.1
Pavlov. Cond. intertrial magazine entries	1.0	1.2	9.9	-3.1	-0.2	0.2	0.2	0.2	0.2	0.7	-0.0	0.7
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	1.3	1.1	0.5	-0.5	0.5	0.5	0.5	0.1	-0.6	0.1
Pavlov. Cond. response bias	0.6	0.8	7.0	2.7	0.3	-0.3	0.2	0.2	0.3	-0.1	-0.3	-0.2
Time in closed arm before self-admin	0.0	0.0	0.1	-0.1	-0.0	0.0	-0.2	-0.1	-0.1	0.0	-0.3	0.1
Time in closed arm after self-admin	0.9	1.0	6.0	2.4	0.8	-0.8	0.5	0.5	0.5	0.3	-0.4	0.4
Time in open arm before self-admin	0.1	0.1	0.1	-0.2	0.2	-0.2	0.4	0.3	0.3	0.3	-0.1	0.3
Time in open arm after self-admin	1.5	1.6	2.5	1.3	-0.8	0.8	-1.2	-1.2	-1.2	-1.6	1.6	-1.5
Bone: periosteal estimation	0.5	1.0	6.3	2.5	0.7	-0.7	0.6	0.6	0.6	0.4	-0.6	0.4
Bone: periosteal perimeter	0.8	1.4	4.9	2.2	0.9	-0.9	1.2	1.1	1.1	0.9	-0.7	0.8
Bone: post-yield work	0.2	0.3	2.1	1.5	0.0	-0.0	-0.2	-0.2	-0.1	-0.4	0.2	-0.4
Progressive ratio test 1 active lever presses	1.0	1.1	3.6	1.9	-0.6	0.6	-0.8	-0.9	-0.9	-0.9	1.1	-1.1
Progressive ratio test 1 breakpoint	1.0	1.1	3.3	1.8	-0.7	0.7	-0.8	-0.9	-0.9	-0.9	1.1	-1.2
Progressive ratio test 1 inactive lever presses	2.8	3.1	18.1	4.3	1.3	-1.3	1.1	1.1	1.1	1.1	-1.0	0.8
Progressive ratio test 2 active lever presses	0.6	0.6	5.2	2.3	0.2	-0.2	0.3	0.2	0.2	0.4	0.1	-0.0
Progressive ratio test 2 breakpoint	0.4	0.4	3.0	1.7	0.3	-0.3	0.3	0.3	0.3	0.5	-0.1	0.2
Progressive ratio test 2 inactive lever presses	4.7	5.4	12.5	3.5	2.0	-2.0	2.2	2.2	2.2	2.3	-2.0	2.0
Incentive Sensitization - Responses	1.1	1.1	2.8	1.7	0.9	-0.9	1.1	1.0	1.0	1.1	-0.8	0.9
Incentive Sensitization - Breakpoint	0.8	0.8	1.2	0.7	0.7	-0.7	1.1	1.0	1.0	1.1	-0.8	1.0
Sum of active levers in priming session hrs 5-6	1.2	1.2	4.8	-2.2	-1.0	1.0	-0.9	-0.9	-0.9	-0.7	0.6	-0.7
Progressive ratio	2.3	2.6	8.4	-2.9	-1.6	1.6	-1.6	-1.5	-1.5	-1.1	0.8	-1.2
Food seeking constrained by brief footshock	1.8	2.2	15.6	4.0	1.0	-1.0	0.8	0.8	0.7	0.4	-0.3	0.4
Seeking ratio, punishment vs. effort	2.3	2.8	5.7	2.4	1.5	-1.5	1.9	1.8	1.7	1.5	-1.0	1.4
Retroperitoneal fat weight	1.0	3.4	20.5	-4.5	-1.3	1.3	-1.2	-1.2	-1.1	-1.1	0.8	-0.9
Reaction time number correct	2.4	3.5	26.9	5.2	0.8	-0.8	0.8	0.8	0.8	0.8	-0.4	0.4
Reaction time mean minus median	0.2	0.3	0.5	-0.7	-0.4	0.4	-0.5	-0.5	-0.5	-0.7	0.4	-0.6
Reaction time mean minus median AUC	0.5	0.6	2.2	1.5	-0.4	0.4	-0.7	-0.7	-0.6	-0.8	0.6	-0.8
Reaction time num false alarms	0.9	1.3	7.8	-2.8	-1.2	1.2	-0.4	-0.4	-0.5	0.2	0.5	-0.2
Reaction time num false alarms AUC	1.4	1.9	9.1	-3.0	-1.6	1.6	-0.8	-0.8	-0.9	-0.2	0.8	-0.6
Reaction time trials correct on left	2.4	3.5	26.9	5.2	0.8	-0.8	0.8	0.8	0.8	0.8	-0.4	0.4
Reaction time trials on left	2.5	3.6	27.9	5.3	0.8	-0.8	0.8	0.8	0.7	0.8	-0.4	0.4
Reaction time mean	0.5	0.7	4.8	2.2	-0.3	0.3	-0.4	-0.4	-0.5	-0.4	0.5	-0.5
Reaction time mean AUC	1.3	1.7	12.7	3.6	-0.3	0.3	-0.6	-0.6	-0.6	-0.6	0.7	-0.8
Median of all reaction times	1.2	1.7	14.5	3.8	-0.2	0.2	-0.3	-0.3	-0.4	-0.2	0.4	-0.5
Reaction time omissions	2.7	3.7	32.4	5.7	0.5	-0.5	0.3	0.3	0.2	0.6	-0.1	0.2
Reaction time false alarm rate	2.9	4.0	28.2	-5.3	-1.6	1.6	-0.8	-0.8	-0.9	-0.2	0.7	-0.4
Reaction time premature initiation rate	0.1	0.2	0.5	0.3	0.0	-0.0	-0.6	-0.5	-0.5	-0.7	0.1	-0.5
Reaction time premature initiations	0.6	0.9	7.3	2.7	0.4	-0.4	-0.1	-0.0	0.0	-0.2	-0.2	-0.2
Std. dev. reaction times	0.9	1.3	5.4	2.3	-0.7	0.7	-0.9	-0.9	-0.9	-1.0	0.9	-1.1
Reaction time trials completed	2.5	3.6	27.9	5.3	0.8	-0.8	0.8	0.8	0.7	0.8	-0.4	0.4
Reaction time trials AUC	2.6	3.8	29.7	5.5	0.9	-0.9	0.9	0.8	0.8	0.8	-0.4	0.4
Run reversals in cocaine runway, females	1.2	1.1	6.3	-2.5	0.3	-0.3	0.9	0.8	0.8	1.0	-0.4	0.8
Run reversals in cocaine runway, males	0.6	0.6	3.2	-1.8	-0.2	0.2	0.2	0.3	0.3	0.8	-0.9	0.6
Latency to leave start box in cocaine runway	0.1	0.1	0.6	0.8	0.4	-0.4	-0.0	0.0	0.0	0.0	-0.3	0.0
Latency to leave start box in cocaine runway, F	0.5	0.6	1.5	-0.6	0.6	-0.6	0.5	0.6	0.7	1.0	-1.2	0.8
Latency to leave start box in cocaine runway, M	0.7	0.6	2.2	1.5	0.1	-0.1	-0.6	-0.6	-0.6	-1.1	0.9	-0.8
Std. dev. time between licks in bursts	3.9	4.7	6.4	0.9	2.1	-2.1	2.5	2.5	2.4	2.3	-1.9	2.3
Total sessions with >9 infusions	3.2	3.6	17.6	4.2	1.5	-1.5	1.3	1.3	1.3	1.4	-1.2	1.1
Short access day 1 total inactive lever presses	2.5	2.8	14.6	3.8	1.0	-1.0	1.4	1.3	1.3	1.4	-0.5	0.8
Short access day 10 total inactive lever presses	16.0	17.7	112.6	10.6	3.0	-3.0	2.2	2.3	2.3	2.1	-2.4	1.8
Short access day 1 total infusions	0.7	0.8	2.3	1.5	0.9	-0.9	0.8	0.8	0.8	0.7	-0.4	0.6
Short access day 10 total infusions	1.5	1.7	14.6	3.8	0.1	-0.1	-0.2	-0.2	-0.2	-0.1	0.4	-0.6
Short access total infusions	0.6	0.7	5.8	2.4	0.1	-0.1	-0.0	-0.1	-0.1	-0.1	0.6	-0.4
Short access day 1 locomotion	1.7	1.9	12.6	3.6	1.2	-1.2	0.6	0.5	0.5	0.3	-0.3	0.4
Short access day 10 total locomotion	0.6	0.6	1.1	0.8	-0.5	0.5	-0.8	-0.8	-0.8	-0.9	1.0	-0.9
Short access total locomotion	1.1	1.2	4.0	2.0	-0.5	0.5	-0.9	-0.9	-0.9	-1.0	1.1	-1.1
One hour access (0.3 mA shock)	1.6	1.9	15.7	4.0	0.2	-0.2	-0.2	-0.3	-0.3	-0.5	0.7	-0.6
Compulsive drug intake	0.7	0.8	1.9	-0.0	-0.6	0.6	-0.8	-0.8	-0.8	-1.4	1.2	-0.9
One hour access (shock baseline)	1.1	1.3	9.7	3.1	0.5	-0.5	0.3	0.3	0.3	0.8	-0.4	0.1
Social response proportion	0.5	0.6	4.6	2.1	0.5	-0.5	0.1	0.2	0.2	0.2	-0.2	0.1
Social responses	0.3	0.4	0.5	0.5	-0.6	0.6	-0.7	-0.6	-0.6	-0.5	0.4	-0.7
Social time	2.2	2.9	3.4	-1.7	1.6	-1.6	1.8	1.8	1.8	1.6	-1.8	1.8
Soleus weight	1.1	3.2	25.9	-5.1	-0.7	0.7	-0.9	-0.7	-0.6	-0.6	-0.5	-0.3
Bone: stiffness	1.5	2.4	21.2	4.6	0.5	-0.5	0.1	0.2	0.2	0.1	-0.3	-0.1
Tibialis anterior weight	0.3	0.9	4.6	-2.1	0.6	-0.6	0.7	0.7	0.7	0.6	-0.8	0.8
Time to tail flick, vehicle, before self-admin	0.7	0.7	3.6	-1.9	-0.8	0.8	-0.7	-0.7	-0.6	-0.3	0.2	-0.4
Time to tail flick, vehicle, after self-admin	4.6	5.0	40.2	-6.3	-0.8	0.8	0.2	0.3	0.3	1.1	-1.0	0.9
Time to tail flick, test, before self-admin	1.7	1.7	2.5	1.3	-0.8	0.8	-1.3	-1.3	-1.3	-1.6	1.4	-1.5
Time to tail flick, test, after self-admin	0.5	0.5	2.4	-1.6	0.2	-0.2	0.5	0.5	0.5	0.7	-0.7	0.7
Delta time to tail flick, vehicle, before/after SA	2.4	2.4	14.3	-3.8	0.1	-0.1	0.9	0.9	0.9	1.4	-1.0	1.2
Delta time to tail flick, test, before/after SA	0.7	0.7	1.0	-0.5	0.6	-0.6	0.9	0.9	0.9	1.0	-0.9	0.9
Tibia length	1.8	5.1	30.9	-5.6	-1.3	1.3	-1.7	-1.5	-1.3	-1.8	0.0	-1.2
Ambulatory time before self-admin	1.2	1.3	2.3	1.5	1.0	-1.0	1.1	1.1	1.1	1.2	-1.1	1.1
Ambulatory time after self-admin	0.7	0.8	6.7	2.6	0.5	-0.5	0.1	0.1	0.1	-0.2	0.1	-0.0
Bone: tissue strength	0.8	0.8	1.9	-0.1	1.0	-1.0	0.7	0.8	0.8	0.8	-1.4	1.0
Total heroin consumption	2.3	2.7	22.1	-4.7	-0.9	0.9	-0.2	-0.1	-0.1	0.6	-0.6	0.4
Bone: trabecular number	1.1	1.7	3.2	0.1	-1.2	1.2	-1.1	-1.2	-1.3	-1.5	1.8	-1.5
Bone: trabecular spacing	1.5	1.9	3.4	-1.7	1.1	-1.1	1.1	1.2	1.2	1.4	-1.8	1.5
Bone: trabecular thickness	1.5	1.8	2.6	-0.8	-1.2	1.2	-1.4	-1.4	-1.4	-1.6	1.5	-1.5
Bone: trabecular tissue density	0.5	0.7	4.4	2.1	-0.3	0.3	-0.6	-0.6	-0.6	-0.6	0.4	-0.7
Water consumed over 24 hours	2.4	2.9	10.0	3.2	1.6	-1.6	1.3	1.4	1.4	1.2	-1.5	1.2
Number of responses in last shaping day	1.4	1.4	2.7	1.7	1.1	-1.1	1.2	1.2	1.1	1.1	-1.0	1.1