Kl

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose alternative TSS XM_039089809.1 0.06 0.04 1.9e-06 0.04 0.04 0.03 0.04 5.2e-05 1.8e-05 9.5e-05 3.0e-05
2 NAcc alternative TSS NM_031336.2 0.07 0.05 2.0e-05 0.04 0.04 0.04 0.04 1.8e-05 1.2e-05 3.2e-05 4.1e-05
3 BLA alternative TSS NM_031336.2 0.11 0.07 2.1e-03 0.04 0.06 0.04 0.04 5.1e-03 6.8e-04 2.0e-03 5.0e-03
4 BLA alternative TSS XM_039089809.1 0.11 0.07 1.9e-03 0.04 0.06 0.04 0.04 4.4e-03 6.2e-04 2.0e-03 4.8e-03
5 NAcc alternative TSS XM_039089809.1 0.06 0.04 3.9e-05 0.04 0.04 0.03 0.03 3.4e-05 3.4e-05 7.9e-05 9.6e-05
6 BLA gene expression Kl 0.12 0.08 9.3e-04 0.01 0.04 0.06 0.02 5.3e-02 3.2e-03 4.4e-04 1.9e-02
7 Adipose gene expression Kl 0.13 0.07 1.1e-11 0.06 0.08 0.08 0.08 6.4e-07 1.4e-09 2.6e-09 2.7e-09
8 NAcc gene expression Kl 0.28 0.11 0.0e+00 0.26 0.28 0.27 0.27 1.5e-30 1.3e-32 1.6e-31 3.7e-31
9 Brain gene expression Kl 0.03 0.02 5.3e-03 0.02 0.02 0 0.01 3.3e-03 6.3e-03 1.2e-01 1.8e-02
10 PL gene expression Kl 0.03 0.02 2.5e-03 0.02 0.02 0.03 0.02 3.6e-03 1.5e-03 3.6e-04 2.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density2.13.57.71.32.82.6-2.62.2-0.80.22.1-1.3-0.9
Area under the delay curve3.33.55.80.7-2.1-1.81.8-2.4-1.3-1.7-2.32.11.7
BMI with tail0.72.46.62.60.81.2-1.2-0.7-0.2-2.3-0.72.31.5
BMI without tail1.32.79.33.00.00.1-0.1-1.01.2-2.5-1.11.72.2
Body weight3.414.154.87.43.73.9-3.80.2-2.0-4.90.12.82.6
Weight adjusted by age0.91.01.80.11.31.1-1.11.30.40.61.3-1.2-0.6
Bone surface1.62.96.32.22.52.5-2.51.4-1.1-0.81.30.0-0.1
Bone volume1.72.96.71.22.62.6-2.61.8-1.20.01.7-0.4-0.8
Breakpoint value in progressive ratio session1.61.82.81.1-1.3-1.21.2-1.70.4-1.5-1.61.51.4
Number of licking bursts0.70.91.50.21.21.0-1.01.2-0.20.61.2-1.1-0.6
Context. condit. distance diff. score1.51.86.02.5-0.4-0.50.5-1.10.5-2.0-1.11.11.8
Locomotion velocity, session 10.70.81.5-0.1-1.2-1.21.2-1.00.9-0.4-1.00.60.8
Locomotion distance, session 10.60.71.7-1.0-1.3-1.31.3-0.60.60.4-0.6-0.10.3
Locomotion velocity, session 20.50.51.00.1-1.0-1.01.0-0.80.6-0.4-0.80.30.6
Locomotion distance, session 20.91.33.2-1.0-1.5-1.81.8-0.41.30.7-0.6-0.90.3
Locomotion velocity, session 30.30.30.60.6-0.4-0.40.4-0.50.6-0.7-0.60.50.8
Locomotion distance, session 30.30.30.9-0.60.20.0-0.10.60.10.80.6-1.0-0.6
Stereotopy head waving bouts, day 30.81.02.21.31.51.4-1.31.0-0.6-0.30.9-0.5-0.2
Stereotopy head waving duration, day 30.20.30.60.10.70.8-0.80.4-0.70.10.50.0-0.4
Locomotion velocity, session 72.22.44.00.5-1.7-1.51.5-2.00.9-1.4-1.91.91.6
Locomotion distance, session 71.82.23.50.5-1.8-1.91.9-1.61.6-1.0-1.60.81.6
Stereotopy head waving bouts, day 70.30.30.7-0.7-0.8-0.80.8-0.3-0.10.3-0.3-0.2-0.2
Stereotopy head waving duration, day 70.20.20.5-0.7-0.5-0.50.5-0.2-0.40.3-0.2-0.0-0.4
Locomotion velocity, session 80.60.71.20.8-0.6-0.50.5-0.90.0-1.0-0.91.11.1
Locomotion distance, session 80.71.02.31.5-0.6-0.60.6-1.00.6-1.4-1.00.91.5
Degree of sensitization distance1.51.52.70.1-1.6-1.61.6-1.41.0-0.7-1.40.91.1
Degree of sensitization stereotypy0.20.20.6-0.4-0.8-0.70.7-0.5-0.2-0.0-0.50.3-0.1
Conditioned locomotion0.50.60.9-0.40.80.8-0.80.9-0.90.70.9-0.6-0.9
Cocaine response after cond. corrected1.71.94.3-0.21.72.1-2.10.7-2.00.20.90.9-1.1
Cocaine response after cond. not corrected0.80.92.40.20.91.3-1.3-0.1-1.5-0.40.21.4-0.4
Cocaine response before conditioning1.72.03.30.9-1.7-1.81.8-1.51.1-1.1-1.50.61.6
Saline control response0.30.41.81.30.3-0.20.20.50.3-0.30.3-1.20.4
Bone: connectivity density1.52.45.12.22.32.1-2.01.6-0.2-0.71.3-0.80.2
Bone: cortical apparent density0.50.71.20.0-1.0-0.90.9-1.10.4-0.6-1.11.10.7
Bone: cortical area1.01.54.92.2-0.10.1-0.1-0.90.2-2.0-1.01.51.4
Bone: cortical porosity0.10.20.50.00.40.3-0.30.4-0.70.20.4-0.4-0.4
Bone: cortical porosity0.10.10.3-0.2-0.5-0.60.6-0.10.00.1-0.2-0.4-0.1
Bone: cortical thickness0.81.34.42.10.10.2-0.2-0.80.2-1.8-0.81.31.3
Bone: cortical thickness0.50.52.01.4-0.3-0.40.4-0.40.6-1.0-0.60.21.0
Bone: cortical tissue density0.40.50.9-0.2-0.9-0.80.8-0.90.3-0.5-0.90.90.5
Condit. Reinf. active minus inactive responses0.30.30.7-0.3-0.7-0.50.5-0.8-0.5-0.2-0.70.90.2
Condit. Reinf. active-inactive response ratio0.50.51.60.1-0.6-0.40.4-1.0-0.5-0.7-0.91.30.4
Condit. Reinf. active responses0.40.51.2-0.3-1.1-1.11.1-0.80.2-0.2-0.80.30.4
Condit. Reinf. inactive responses0.91.12.8-0.5-1.5-1.71.7-0.61.20.2-0.7-0.50.5
Incentive salience index mean0.30.40.9-0.5-1.0-0.90.9-0.7-0.0-0.0-0.70.30.2
Condit. Reinf. lever presses0.40.51.3-0.3-1.0-1.21.1-0.60.80.1-0.6-0.10.4
Condit. Reinf. active minus inactive responses2.22.74.12.0-1.4-1.41.4-1.61.3-2.0-1.81.22.0
Condit. Reinf. active-inactive response ratio2.42.53.51.5-1.6-1.61.6-1.71.3-1.7-1.81.11.9
Condit. Reinf. active responses2.33.24.82.2-1.5-1.61.6-1.81.3-2.2-1.91.32.1
Condit. Reinf. inactive responses0.10.20.60.8-0.3-0.40.4-0.30.1-0.6-0.40.10.4
Condit. Reinf. lever presses0.30.40.50.7-0.7-0.70.7-0.60.6-0.7-0.70.30.7
Condit. Reinf. lever reinforcers received2.43.44.51.9-1.8-1.81.9-1.91.4-2.1-2.01.22.1
Conditioned reinforcement - actives1.01.04.82.20.1-0.10.2-0.11.3-1.3-0.3-0.31.2
Conditioned reinforcement - inactives0.60.61.80.10.80.6-0.61.0-1.30.50.9-1.1-0.2
Conditioned locomotion0.60.73.92.00.2-0.10.1-0.2-0.7-1.2-0.3-0.11.1
Patch foraging indifference point 0 sec1.93.15.0-1.21.71.4-1.52.2-1.11.92.1-2.0-2.0
Patch foraging indifference point AUC0.10.10.40.60.30.1-0.10.3-0.6-0.10.3-0.60.1
Delay disc. indifference point, 0s delay2.52.710.21.6-0.40.2-0.2-2.00.1-2.3-1.63.21.5
Delay disc. indifference point, 16s delay1.31.32.20.2-1.5-1.41.4-1.4-0.7-0.8-1.40.81.0
Delay disc. indifference point, 2s delay3.33.77.80.5-2.1-1.61.6-2.7-0.7-1.8-2.52.81.4
Delay disc. indifference point, 24s delay0.90.91.7-0.1-1.1-1.01.0-1.1-1.3-0.5-1.10.80.8
Delay disc. indifference point, 4s delay1.81.94.20.5-1.3-1.01.0-1.8-1.1-1.3-1.72.01.1
Delay disc. indifference point, 8s delay1.71.72.80.3-1.7-1.61.6-1.5-1.3-0.9-1.50.91.1
Indifference point function ln k0.40.52.7-0.3-0.2-0.50.50.51.60.60.3-1.2-0.2
Indifference point function log k0.40.52.7-0.3-0.2-0.50.50.51.60.60.3-1.2-0.2
Patch foraging total patch changes 0 sec2.33.86.2-1.41.81.4-1.42.5-1.02.22.3-2.5-2.2
Patch foraging total patch changes 12 sec1.11.41.9-0.41.31.2-1.21.4-1.21.01.4-1.0-1.3
Patch foraging total patch changes 18 sec2.83.65.2-1.11.91.6-1.62.3-2.21.92.2-2.0-2.0
Patch foraging total patch changes 24 sec1.21.45.6-0.90.4-0.0-0.01.50.41.51.3-2.4-1.2
Patch foraging total patch changes 6 sec1.92.84.3-0.81.71.4-1.42.1-1.61.62.0-2.0-1.8
Patch foraging time to switch 0 sec1.01.58.6-0.50.41.2-1.2-1.0-1.3-0.6-0.52.9-0.2
Patch foraging water rate 0 sec1.42.210.70.41.10.3-0.32.10.71.11.7-3.3-0.7
Patch foraging water rate 12 sec0.40.63.20.0-0.4-0.80.80.61.10.50.2-1.8-0.0
Patch foraging water rate 18 sec1.41.85.40.2-1.6-1.91.9-0.82.3-0.3-1.0-0.61.0
Patch foraging water rate 24 sec0.30.41.61.20.1-0.30.30.40.6-0.30.2-1.20.5
Patch foraging water rate 6 sec0.50.85.30.20.0-0.30.30.52.30.30.4-1.40.1
Seeking ratio, delayed vs. immediate footshock2.62.911.4-2.20.70.7-0.81.33.42.01.4-1.2-1.6
Distance traveled before self-admin1.11.22.00.3-1.4-1.31.3-1.4-0.2-0.8-1.31.01.0
Distance traveled after self-admin0.50.50.90.2-0.9-1.01.0-0.6-1.0-0.3-0.7-0.10.5
Extensor digitorum longus weight1.03.820.44.51.21.1-1.0-0.30.4-2.9-0.40.92.1
Bone: elastic displacement0.20.20.40.40.60.5-0.50.5-0.10.00.5-0.5-0.1
Bone: elastic work0.81.03.11.71.41.2-1.20.8-0.5-0.70.7-0.40.1
Bone: endosteal estimation0.61.22.20.51.41.2-1.21.5-0.60.51.3-1.4-0.6
Bone: endosteal perimeter0.10.21.21.10.30.1-0.00.30.2-0.40.1-0.60.3
Epididymis fat weight0.20.40.80.8-0.3-0.20.2-0.70.4-0.9-0.60.90.6
Delta time in closed arm before/after self-admin0.90.93.20.7-0.8-0.80.8-0.8-1.8-0.8-0.90.50.9
Delta time in open arm before/after self-admin1.41.46.9-1.8-0.6-0.50.50.02.61.20.1-0.4-1.1
Diff in mean of infusions in LGA sessions0.20.30.70.2-0.7-0.80.8-0.30.3-0.1-0.4-0.30.6
Delay discount exponential model param3.63.86.1-0.62.32.1-2.12.51.11.72.4-2.0-1.7
Extinction: sum of active levers before priming0.80.81.7-0.6-1.3-1.21.2-0.91.00.0-0.90.30.4
Active lever presses in extinction session 60.00.00.00.20.0-0.00.00.00.1-0.1-0.0-0.10.2
Bone: final force0.71.15.32.30.50.5-0.5-0.3-0.1-1.7-0.40.81.1
Bone: final moment0.50.84.02.00.60.6-0.6-0.1-0.3-1.4-0.20.60.8
Food consumed during 24 hour testing period0.91.11.7-0.41.21.1-1.11.3-0.60.91.3-1.2-1.1
Glucose0.30.41.3-0.1-0.7-0.40.4-0.80.1-0.5-0.81.10.5
Heart weight0.91.33.50.6-1.5-1.91.9-0.70.3-0.4-0.9-0.81.1
Delay discount hyperbolic model param3.23.45.8-0.62.21.9-1.92.41.21.62.3-2.1-1.5
Intermittent access intake day 1-15 change1.01.02.00.31.20.9-0.91.30.90.61.2-1.4-0.5
Intermittent access intake escalation0.80.83.60.50.70.3-0.30.91.90.30.7-1.3-0.0
Intermittent access intake escalation 20.50.51.9-0.40.2-0.10.10.71.40.70.6-1.3-0.3
Intermitt. access day 1 inactive lever presses0.91.02.1-0.21.10.9-0.91.30.40.81.2-1.5-0.6
Intermitt. access day 15 inactive lever presses2.52.76.7-0.81.92.2-2.21.3-2.60.91.50.2-1.4
Intermitt. access escalation Index1.71.510.0-0.2-1.0-1.21.2-0.53.20.1-0.5-0.50.5
Intermittent access day 1 total infusions1.61.86.5-0.1-1.6-1.61.6-1.22.6-0.4-1.20.41.0
Intermittent access day 15 total infusions1.21.411.30.0-0.5-0.70.70.03.40.2-0.1-0.90.3
Intermittent access terminal intake (last 3 days)0.70.86.4-0.4-0.5-0.60.6-0.02.50.4-0.1-0.6-0.1
Intermittent access total infusions1.01.15.7-0.1-1.1-1.11.1-0.92.4-0.3-0.90.40.6
Intermittent access day 1 locomotion1.71.83.2-0.4-1.7-1.61.6-1.51.8-0.4-1.40.81.0
Intermittent access day 15 total locomotion2.02.19.40.8-1.3-1.51.5-1.03.1-0.8-1.1-0.01.4
Intermittent access total locomotion2.12.44.80.1-1.9-1.91.9-1.62.2-0.8-1.60.71.4
Intermittent access standard deviation2.42.53.8-0.52.01.9-1.91.8-1.91.11.8-0.9-1.4
Left kidney weight1.95.425.55.12.32.1-2.10.6-1.7-2.80.40.41.6
Right kidney weight1.64.519.04.42.42.2-2.20.7-1.5-2.40.60.61.3
Cocaine induced anxiety0.40.51.0-0.1-1.0-1.01.0-0.8-0.2-0.3-0.80.50.7
Post-drug Anxiety1.92.14.0-0.8-2.0-1.71.7-1.90.7-0.6-1.71.71.0
Baseline Anxiety0.91.02.8-1.0-0.9-0.40.4-1.11.7-0.1-0.91.70.2
Tail length1.85.427.35.20.90.7-0.7-0.80.5-3.6-0.91.62.8
Length with tail3.312.057.77.63.03.0-2.90.0-1.3-4.8-0.11.92.8
Length without tail2.76.018.94.32.62.8-2.80.4-2.6-2.80.31.51.1
Times rat made contact with spout0.30.41.31.2-0.1-0.20.2-0.40.7-0.9-0.40.20.8
Lifetime Intake0.50.63.5-0.3-0.7-0.50.5-0.61.9-0.1-0.60.50.3
Liver weight, left2.33.65.9-0.22.42.2-2.22.3-1.61.22.2-1.7-1.8
Liver weight, right0.91.53.92.01.61.4-1.40.9-1.4-0.70.8-0.40.1
Locomotor activity1.52.45.52.4-1.3-1.71.7-1.30.7-1.8-1.50.21.8
Locomotor testing distance0.10.20.60.80.2-0.10.10.30.4-0.10.3-0.80.0
Locomotor testing rearing0.50.71.4-0.80.50.3-0.41.0-0.41.11.0-1.1-1.2
Locomotion in novel chamber0.40.54.40.60.1-0.10.10.22.1-0.20.1-0.50.1
Locomotion in novel chamber post-restriction0.70.93.41.8-0.5-0.80.8-0.40.9-1.2-0.6-0.51.0
Fecal boli incidents, locomotor time 10.40.51.41.2-0.3-0.50.5-0.30.9-0.8-0.4-0.00.9
Change in fecal boli incidents, locomotor task0.50.50.9-0.80.70.9-0.90.5-0.10.60.70.2-1.0
Time >=10cm from walls, locomotor time 10.80.81.6-0.6-1.1-0.70.7-1.30.8-0.4-1.11.20.3
Bouts of movement, locomotor time 10.20.21.41.20.20.0-0.00.0-0.1-0.6-0.0-0.10.2
Total resting periods, locomotor time 10.20.21.41.2-0.0-0.10.1-0.1-0.3-0.7-0.20.00.2
Rest time, locomotor task time 10.20.20.70.80.30.3-0.3-0.10.6-0.6-0.10.3-0.1
Distance moved, locomotor task time 10.50.51.0-0.2-0.9-1.01.0-0.6-1.0-0.1-0.60.00.8
Vertical activity count, locomotor time 10.60.72.60.3-0.9-1.11.1-0.4-1.6-0.3-0.6-0.40.6
Time >=10cm from walls, locomotor time 21.01.03.51.2-0.00.4-0.3-1.10.6-1.5-0.91.90.6
Bouts of movement, locomotor time 20.20.21.31.20.20.1-0.10.1-0.1-0.6-0.0-0.3-0.0
Total resting periods, locomotor time 20.20.21.01.00.50.4-0.40.3-0.2-0.40.2-0.3-0.3
Rest time, locomotor task time 20.10.10.2-0.4-0.2-0.10.1-0.10.50.2-0.00.1-0.4
Distance moved, locomotor task time 20.20.21.70.10.30.1-0.10.4-1.30.20.3-0.40.0
Vertical activity count, locomotor time 20.50.52.11.00.60.4-0.40.6-1.5-0.20.4-0.90.0
Light reinforcement 11.62.84.70.0-2.2-2.02.0-1.82.1-0.9-1.91.11.3
Light reinforcement 20.10.10.3-0.50.10.1-0.10.3-0.20.50.3-0.6-0.6
Bone: marrow area0.61.32.50.41.51.2-1.21.6-0.50.61.4-1.5-0.7
Bone: maximum diameter0.40.72.11.41.11.1-1.00.4-0.4-0.70.40.20.2
Bone: maximum force0.40.73.71.90.70.6-0.60.2-0.0-1.10.00.10.7
Bone: maximum moment0.30.52.61.60.80.7-0.70.4-0.2-0.80.2-0.10.4
Mean time between licks in bursts0.40.62.6-1.6-0.4-0.50.50.30.11.20.3-0.7-0.7
Mean num. licks in bursts0.30.40.60.3-0.7-0.60.6-0.80.4-0.6-0.80.70.6
Cd content in liver1.51.64.1-1.8-0.8-1.21.10.41.31.70.5-2.0-0.6
Co content in liver1.41.73.5-0.51.41.1-1.11.80.01.31.7-1.9-1.0
Cu content in liver0.40.51.8-0.70.30.1-0.10.70.30.90.7-1.3-0.8
Fe content in liver0.70.92.61.6-0.4-0.60.6-0.71.4-1.1-0.6-0.11.1
K content in liver0.10.10.40.20.00.1-0.1-0.1-0.6-0.2-0.10.1-0.0
Mg content in liver0.10.10.50.70.30.3-0.30.1-0.4-0.40.00.00.2
Mn content in liver0.50.51.2-1.10.50.6-0.60.4-0.71.00.8-0.5-0.9
Na content in liver0.40.40.80.8-0.3-0.20.2-0.70.0-0.9-0.70.90.7
Rb content in liver0.40.52.2-1.5-0.6-0.60.5-0.1-0.30.9-0.0-0.3-0.6
Se content in liver1.62.03.71.6-0.8-0.50.5-1.81.0-1.9-1.51.91.7
Sr content in liver2.32.13.4-0.61.81.7-1.71.8-0.81.31.8-1.3-1.2
Zn content in liver2.02.24.80.92.22.0-2.01.8-0.70.31.7-1.0-0.5
Bone: minimum diameter0.00.00.1-0.10.10.1-0.10.3-0.10.20.2-0.3-0.2
Time in familiar zone, hab. session 11.91.82.4-1.21.41.5-1.51.4-1.21.31.5-0.7-1.6
Time in novel zone, hab. session 10.70.71.21.1-0.6-0.60.6-0.90.3-1.1-0.90.71.0
Total zone transitions, hab. session 11.31.84.3-0.6-2.0-2.12.1-1.40.9-0.1-1.40.40.8
Total locomotion distance, hab. session 10.60.81.7-0.2-1.3-1.21.2-1.20.2-0.4-1.10.80.6
Locomotion velocity, hab. session 11.11.53.3-0.5-1.8-1.71.7-1.40.5-0.3-1.40.80.7
Time in familiar zone, hab. session 20.30.30.9-0.10.70.9-0.90.3-0.50.00.40.5-0.3
Time in novel zone, hab. session 20.60.61.6-0.2-1.1-1.31.2-0.60.5-0.1-0.7-0.20.4
Total zone transitions, hab. session 20.20.30.50.5-0.6-0.70.7-0.50.4-0.4-0.50.10.7
Total locomotion distance, hab. session 20.20.30.8-0.1-0.8-0.90.9-0.60.2-0.1-0.60.10.3
Locomotion velocity, hab. session 20.20.30.8-0.1-0.8-0.90.9-0.50.2-0.1-0.50.00.3
Novel to familiar place preference ratio0.10.10.30.1-0.5-0.60.6-0.4-0.1-0.2-0.40.10.2
Novelty place preference0.20.20.5-0.1-0.7-0.70.7-0.4-0.0-0.1-0.50.00.2
Time in novel zone, NPP test0.10.10.40.0-0.6-0.60.6-0.4-0.0-0.2-0.40.10.2
Total zone transitions, NPP test0.40.60.90.4-0.9-0.90.9-0.80.7-0.6-0.80.40.9
Total locomotion distance, NPP test1.21.72.50.6-1.6-1.51.5-1.60.7-1.1-1.61.11.3
Locomotion velocity, NPP test1.41.93.20.7-1.7-1.81.8-1.60.9-1.1-1.60.81.4
Intraocular pressure0.20.31.41.20.50.3-0.30.2-0.9-0.40.3-0.4-0.0
Delta distance traveled before/after self-admin0.30.31.6-0.30.30.0-0.10.7-0.30.60.5-1.2-0.4
Delta ambulatory time before/after self-admin0.30.31.1-0.70.1-0.10.00.60.20.80.5-1.1-0.6
Parametrial fat weight0.50.92.2-0.11.41.5-1.51.0-0.50.31.0-0.0-0.9
Pavlov. Cond. lever latency0.81.12.41.31.51.4-1.41.0-0.6-0.30.9-0.4-0.1
Pavlov. Cond. magazine entry latency0.40.50.90.8-0.6-0.60.6-0.80.9-0.8-0.70.50.9
Pavlov. Cond. change in total contacts1.21.32.70.3-1.2-0.90.9-1.50.5-1.0-1.41.70.9
Pavlov. Cond. index score0.50.61.00.2-0.9-0.80.8-1.00.8-0.6-0.90.80.7
Pavlov. Cond. latency score0.70.91.50.0-1.2-1.11.1-1.20.9-0.6-1.10.90.8
Pavlov. Cond. lever contacts0.60.71.5-1.0-1.2-1.11.1-0.90.50.1-0.80.60.2
Pavlov. Cond. magazine entry number0.80.91.7-1.00.80.9-0.90.9-1.31.00.9-0.5-1.1
Pavlov. Cond. intertrial magazine entries0.40.51.6-1.3-0.3-0.40.40.4-0.01.00.3-0.9-0.6
Pavlov. Cond. lever-magazine prob. diff.0.30.40.70.1-0.7-0.50.5-0.80.6-0.5-0.70.80.5
Pavlov. Cond. response bias0.50.60.80.5-0.8-0.80.8-0.90.9-0.7-0.80.60.7
Pavlov. Cond. lever latency2.22.94.3-0.82.12.1-2.11.9-1.31.42.0-1.1-1.8
Pavlov. Cond. magazine entry latency2.42.84.70.1-2.2-1.91.9-2.20.7-1.2-2.11.81.4
Pavlov. Cond. change in total contacts1.41.93.60.4-1.8-1.91.9-1.41.2-0.8-1.50.51.3
Pavlov. Cond. index score2.53.25.70.3-2.4-2.42.4-2.01.3-1.1-2.11.11.7
Pavlov. Cond. latency score2.22.84.80.2-2.2-2.12.1-2.01.1-1.1-2.01.21.5
Pavlov. Cond. lever contacts1.72.33.50.6-1.9-1.81.8-1.81.0-1.2-1.81.11.5
Pavlov. Cond. magazine entry number2.02.55.00.22.22.1-2.11.9-0.90.71.8-1.0-1.2
Pavlov. Cond. intertrial magazine entries0.10.10.40.60.30.1-0.10.40.4-0.10.3-0.60.2
Pavlov. Cond. lever-magazine prob. diff.2.73.56.20.3-2.5-2.52.5-2.11.4-1.1-2.11.11.7
Pavlov. Cond. response bias2.93.96.70.4-2.6-2.52.5-2.31.3-1.3-2.31.31.9
Time in closed arm before self-admin0.60.61.60.71.00.7-0.71.10.30.20.9-1.3-0.6
Time in closed arm after self-admin0.70.73.91.0-0.3-0.60.60.1-2.0-0.4-0.2-0.90.4
Time in open arm before self-admin0.60.71.80.8-0.6-0.60.6-0.8-0.9-0.9-0.80.71.4
Time in open arm after self-admin0.20.21.4-0.60.00.2-0.2-0.01.20.30.10.2-0.4
Bone: periosteal estimation0.30.62.91.70.80.7-0.70.4-0.2-0.90.2-0.10.5
Bone: periosteal perimeter0.61.02.31.5-0.7-0.70.7-0.80.7-1.3-1.00.51.3
Bone: post-yield work0.10.10.20.30.40.3-0.30.50.20.00.3-0.4-0.1
Progressive ratio test 1 active lever presses0.10.10.60.80.10.0-0.0-0.10.3-0.5-0.1-0.00.5
Progressive ratio test 1 breakpoint0.10.10.70.80.1-0.00.0-0.2-0.0-0.6-0.20.10.5
Progressive ratio test 1 inactive lever presses0.20.21.20.70.30.0-0.00.50.1-0.00.4-1.10.2
Progressive ratio test 2 active lever presses0.80.91.71.3-0.8-1.11.1-0.61.0-1.0-0.8-0.31.2
Progressive ratio test 2 breakpoint1.11.22.11.1-1.2-1.41.4-0.90.9-1.0-1.1-0.21.3
Progressive ratio test 2 inactive lever presses0.70.83.80.90.80.3-0.31.2-0.70.20.9-1.9-0.0
Incentive Sensitization - Responses0.70.72.00.1-1.2-1.41.4-0.60.4-0.2-0.7-0.60.7
Incentive Sensitization - Breakpoint0.80.82.20.1-1.2-1.51.5-0.60.7-0.2-0.7-0.70.8
Sum of active levers in priming session hrs 5-60.30.32.0-0.2-0.10.3-0.3-0.60.1-0.3-0.41.4-0.1
Progressive ratio0.30.31.0-1.00.50.6-0.60.50.00.80.6-0.2-0.6
Food seeking constrained by brief footshock2.63.25.7-2.21.41.2-1.22.00.82.42.0-1.9-2.0
Seeking ratio, punishment vs. effort0.20.30.70.10.60.4-0.40.7-0.30.30.6-0.8-0.5
Retroperitoneal fat weight0.41.47.5-0.3-0.70.0-0.0-1.6-0.4-0.9-1.32.70.5
Reaction time number correct0.50.72.7-0.20.60.2-0.21.20.50.91.0-1.7-0.6
Reaction time mean minus median5.67.410.61.9-2.9-2.72.8-3.32.0-2.7-3.22.52.9
Reaction time mean minus median AUC3.24.16.70.6-2.5-2.62.6-2.12.4-1.3-2.20.91.9
Reaction time num false alarms2.53.45.90.6-2.3-2.32.3-1.72.4-1.1-1.91.01.7
Reaction time num false alarms AUC1.72.33.70.6-1.8-1.91.9-1.41.8-1.0-1.60.81.4
Reaction time trials correct on left0.50.72.7-0.20.60.2-0.21.20.50.91.0-1.7-0.6
Reaction time trials on left0.40.62.5-0.10.50.1-0.11.10.50.80.9-1.6-0.6
Reaction time mean2.53.45.9-0.2-2.4-2.12.1-2.41.3-1.1-2.32.11.3
Reaction time mean AUC2.53.46.0-0.4-2.4-2.22.2-2.31.5-1.0-2.21.81.3
Median of all reaction times1.42.03.7-1.0-1.9-1.61.6-1.80.8-0.4-1.71.70.6
Reaction time omissions1.31.72.90.2-1.7-1.51.5-1.60.9-1.0-1.61.21.1
Reaction time false alarm rate2.12.94.00.8-2.0-1.91.9-1.91.5-1.4-2.01.61.7
Reaction time premature initiation rate1.11.42.90.9-1.1-1.01.0-1.31.7-1.1-1.31.01.3
Reaction time premature initiations0.60.83.60.7-0.8-0.90.9-0.71.9-0.6-0.70.20.9
Std. dev. reaction times3.34.77.40.9-2.5-2.32.3-2.71.6-1.9-2.62.22.0
Reaction time trials completed0.40.62.5-0.10.50.1-0.11.10.50.80.9-1.6-0.6
Reaction time trials AUC0.40.62.7-0.30.4-0.00.01.10.60.90.9-1.6-0.6
Run reversals in cocaine runway, females0.30.21.1-0.8-0.00.0-0.00.30.20.60.3-0.3-1.1
Run reversals in cocaine runway, males0.60.62.5-0.6-0.2-0.60.50.7-1.00.90.5-1.6-0.1
Latency to leave start box in cocaine runway0.60.73.40.3-0.4-0.30.3-0.71.8-0.6-0.60.91.0
Latency to leave start box in cocaine runway, F0.50.51.70.30.91.0-1.00.2-1.3-0.20.30.70.1
Latency to leave start box in cocaine runway, M3.33.216.3-0.2-1.9-2.02.0-1.14.0-0.2-1.2-0.11.3
Std. dev. time between licks in bursts0.40.51.10.5-0.7-0.90.9-0.41.0-0.4-0.5-0.20.7
Total sessions with >9 infusions0.30.31.40.4-0.3-0.30.3-0.51.2-0.5-0.50.50.7
Short access day 1 total inactive lever presses0.30.30.5-0.10.70.7-0.70.60.40.40.6-0.4-0.4
Short access day 10 total inactive lever presses2.52.85.40.52.32.2-2.21.8-2.00.51.8-1.0-1.0
Short access day 1 total infusions0.91.02.4-1.50.81.0-1.00.8-0.71.21.0-0.0-1.1
Short access day 10 total infusions0.30.30.9-1.0-0.6-0.50.5-0.20.70.5-0.2-0.2-0.3
Short access total infusions0.30.31.2-0.60.20.5-0.5-0.21.10.1-0.01.0-0.3
Short access day 1 locomotion2.52.711.10.1-1.6-1.41.4-1.63.3-0.9-1.51.41.2
Short access day 10 total locomotion0.20.20.6-0.80.30.3-0.40.40.60.60.4-0.2-0.6
Short access total locomotion0.70.83.9-0.4-0.7-0.40.4-0.92.0-0.3-0.71.10.4
One hour access (0.3 mA shock)0.80.94.1-0.3-0.6-1.11.10.41.00.70.2-2.00.1
Compulsive drug intake0.90.93.9-2.0-0.6-0.70.60.20.21.40.2-0.8-1.0
One hour access (shock baseline)0.80.91.81.3-0.7-1.01.0-0.41.1-0.9-0.7-0.61.2
Social response proportion3.33.610.63.3-0.7-0.70.7-1.80.2-2.9-1.81.72.4
Social responses0.91.13.21.8-0.6-0.90.9-0.61.1-1.3-0.8-0.11.5
Social time1.62.14.8-0.9-2.2-2.22.2-1.51.1-0.1-1.50.40.8
Soleus weight0.20.62.61.61.00.8-0.80.60.3-0.60.5-0.50.4
Bone: stiffness0.71.12.21.5-0.9-1.01.0-0.90.9-1.3-1.10.41.4
Tibialis anterior weight1.65.526.35.11.11.2-1.1-0.70.3-3.6-0.81.82.6
Time to tail flick, vehicle, before self-admin1.92.03.60.3-1.4-1.11.1-1.81.8-1.1-1.61.90.9
Time to tail flick, vehicle, after self-admin1.01.11.90.2-1.3-1.41.4-1.10.7-0.6-1.10.41.3
Time to tail flick, test, before self-admin0.70.64.60.70.60.5-0.50.4-2.1-0.20.3-0.10.4
Time to tail flick, test, after self-admin0.50.52.00.50.30.6-0.6-0.4-0.7-0.7-0.31.40.7
Delta time to tail flick, vehicle, before/after SA0.50.51.7-0.8-0.1-0.40.40.5-1.30.80.4-1.2-0.2
Delta time to tail flick, test, before/after SA0.20.20.9-0.40.20.4-0.40.01.00.20.20.5-0.3
Tibia length1.33.69.03.02.52.7-2.60.8-1.3-1.70.71.20.4
Ambulatory time before self-admin2.02.13.20.8-1.8-1.71.7-1.8-0.1-1.3-1.81.11.4
Ambulatory time after self-admin0.60.61.30.1-1.1-1.11.1-0.8-0.5-0.4-0.90.10.7
Bone: tissue strength2.32.33.2-1.11.61.5-1.51.8-1.21.51.7-1.4-1.7
Total heroin consumption2.52.96.7-1.0-2.6-2.62.5-1.80.3-0.2-1.80.70.9
Bone: trabecular number1.21.94.31.82.12.0-2.01.3-0.5-0.51.2-0.4-0.1
Bone: trabecular spacing0.60.73.6-1.9-0.9-0.80.8-0.30.01.1-0.2-0.1-0.6
Bone: trabecular thickness1.01.23.61.91.61.5-1.50.8-0.2-0.80.70.00.3
Bone: trabecular tissue density5.17.211.11.9-2.8-2.52.5-3.31.4-2.9-3.32.82.8
Water consumed over 24 hours0.60.81.51.11.21.0-1.01.0-0.2-0.10.9-0.9-0.3
Number of responses in last shaping day0.10.10.60.00.30.2-0.20.4-0.80.20.3-0.5-0.4