Hub : Genes

Kif20b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Kif20b	0.04	0.03	3.3e-03	0.02	0.01	0.02	0.02	1.2e-02	1.9e-02	4.2e-03	5.3e-03
2	Liver	gene expression	Kif20b	0.11	0.06	3.4e-13	0.1	0.07	0.08	0.05	1.3e-11	1.7e-08	1.3e-09	3.2e-06
3	LHb	gene expression	Kif20b	0.13	0.09	8.7e-03	0.04	-0	-0	0.01	4.5e-02	4.3e-01	3.5e-01	1.7e-01
4	NAcc	intron excision ratio	chr1_241886058_241887753	0.02	0.01	2.9e-03	0.01	0.01	0	0.01	6.0e-03	2.4e-02	6.4e-02	1.9e-02
5	pVTA	gene expression	Kif20b	0.04	0.03	2.9e-03	0	0.03	0.02	0.01	1.4e-01	2.6e-03	1.8e-02	4.6e-02
6	NAcc	intron excision ratio	chr1_241886040_241887753	0.02	0.02	2.6e-03	0.01	0.01	0	0.01	1.6e-02	2.1e-02	7.4e-02	2.7e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	3.9	6.7	10.6	3.3	-3.1	0.8	-2.6	2.6	2.3
Area under the delay curve	2.2	2.6	5.4	2.3	-1.2	-1.2	-1.9	0.7	1.7
BMI with tail	0.8	2.8	6.0	-1.8	0.6	0.8	2.4	-1.2	-2.3
BMI without tail	0.8	2.3	4.8	-0.5	0.8	-1.4	1.9	-1.6	-2.2
Body weight	1.1	4.7	11.6	1.8	-0.8	-3.4	1.9	-1.6	-2.4
Weight adjusted by age	0.1	0.2	0.6	-0.0	0.4	-0.2	-0.7	0.1	0.5
Bone surface	3.0	5.5	9.8	3.1	-2.5	0.1	-2.6	2.4	2.1
Bone volume	3.3	6.0	11.8	3.4	-2.8	-0.1	-2.6	2.3	2.1
Breakpoint value in progressive ratio session	0.8	1.0	1.9	0.9	-0.3	-1.4	1.0	-1.0	-1.2
Number of licking bursts	5.6	9.1	13.7	-2.7	3.1	-1.8	3.1	-3.7	-3.4
Context. condit. distance diff. score	0.3	0.4	0.6	0.0	-0.7	0.7	0.8	0.3	-0.8
Locomotion velocity, session 1	1.1	1.2	4.2	-2.0	1.5	0.7	0.1	-0.7	-0.2
Locomotion distance, session 1	0.2	0.2	0.5	-0.7	0.3	0.7	0.0	-0.1	-0.1
Locomotion velocity, session 2	1.1	1.3	3.6	-1.9	1.2	1.6	0.2	-0.4	-0.3
Locomotion distance, session 2	0.7	1.0	1.8	-1.1	1.0	-0.6	0.9	-1.3	-1.0
Locomotion velocity, session 3	0.2	0.3	0.4	0.4	-0.6	-0.4	0.6	-0.1	-0.7
Locomotion distance, session 3	0.5	0.5	1.0	0.6	-0.8	-0.5	1.0	-0.2	-1.0
Stereotopy head waving bouts, day 3	1.1	1.3	2.7	-0.7	0.5	1.3	-1.5	0.8	1.6
Stereotopy head waving duration, day 3	1.0	1.1	3.0	-0.2	0.1	0.9	-1.5	0.9	1.7
Locomotion velocity, session 7	0.2	0.2	0.5	0.7	-0.5	-0.6	0.3	-0.2	-0.4
Locomotion distance, session 7	0.4	0.5	1.7	1.3	-1.1	-0.4	-0.3	0.3	0.2
Stereotopy head waving bouts, day 7	0.1	0.2	0.5	-0.7	0.7	0.2	0.1	0.0	0.0
Stereotopy head waving duration, day 7	0.2	0.2	0.6	-0.8	0.6	0.3	0.3	-0.0	0.0
Locomotion velocity, session 8	0.1	0.1	0.4	0.2	-0.6	0.0	-0.1	0.5	0.0
Locomotion distance, session 8	0.2	0.3	0.7	-0.5	-0.4	0.6	0.7	-0.1	-0.9
Degree of sensitization distance	0.2	0.2	0.5	0.6	-0.1	-0.1	-0.7	0.1	0.7
Degree of sensitization stereotypy	0.1	0.1	0.2	0.3	-0.3	-0.4	0.3	0.2	-0.2
Conditioned locomotion	1.4	1.6	3.4	1.7	-1.8	-0.5	-1.1	1.2	0.7
Cocaine response after cond. corrected	0.4	0.4	1.0	1.0	-0.6	0.2	-0.7	0.7	0.6
Cocaine response after cond. not corrected	0.7	0.9	3.2	1.8	-0.8	-0.8	-0.6	0.4	0.5
Cocaine response before conditioning	0.7	0.8	2.9	1.2	0.0	-1.7	0.0	-0.7	-0.2
Saline control response	2.1	2.8	7.0	2.6	-2.6	-0.4	-0.7	1.4	0.4
Bone: connectivity density	2.8	4.4	6.6	2.1	-2.0	1.0	-2.6	2.2	2.3
Bone: cortical apparent density	1.2	1.7	4.1	0.1	-0.1	1.0	-1.8	1.2	2.0
Bone: cortical area	2.0	3.0	10.5	3.2	-2.0	-1.1	-1.2	1.0	0.5
Bone: cortical porosity	0.1	0.1	0.4	-0.2	0.3	0.3	0.3	-0.2	-0.6
Bone: cortical porosity	0.1	0.1	0.3	0.2	0.2	-0.2	0.2	-0.3	-0.6
Bone: cortical thickness	0.7	1.2	4.2	2.0	-0.6	-1.5	-0.2	-0.3	-0.5
Bone: cortical thickness	0.5	0.6	1.5	1.2	-0.6	-0.8	-0.8	0.3	0.4
Bone: cortical tissue density	1.1	1.5	3.8	-0.1	0.0	1.1	-1.7	1.1	1.9
Condit. Reinf. active minus inactive responses	0.5	0.5	1.2	-0.1	1.1	-0.8	0.5	-0.8	-0.6
Condit. Reinf. active-inactive response ratio	0.8	0.8	2.3	-1.2	1.5	0.3	0.6	-0.6	-0.7
Condit. Reinf. active responses	0.3	0.4	0.9	0.5	0.1	-0.9	0.6	-0.5	-0.6
Condit. Reinf. inactive responses	0.4	0.5	0.9	0.9	-1.0	-1.0	0.5	-0.2	-0.4
Incentive salience index mean	0.7	0.9	1.8	0.3	0.9	-1.4	0.8	-1.0	-1.0
Condit. Reinf. lever presses	0.4	0.5	1.4	0.1	0.6	-1.2	0.6	-0.7	-0.8
Condit. Reinf. active minus inactive responses	0.5	0.7	1.0	-0.2	0.8	-0.7	0.9	-1.0	-1.0
Condit. Reinf. active-inactive response ratio	0.4	0.5	0.7	-0.5	0.8	0.1	0.8	-0.8	-0.9
Condit. Reinf. active responses	0.3	0.4	0.7	0.4	0.1	-0.7	0.7	-0.7	-0.9
Condit. Reinf. inactive responses	0.3	0.4	1.0	1.0	-0.7	-1.0	0.1	-0.1	-0.3
Condit. Reinf. lever presses	0.1	0.2	0.6	-0.2	0.8	-0.3	0.1	-0.4	-0.5
Condit. Reinf. lever reinforcers received	0.4	0.5	0.9	0.1	0.5	-0.8	0.8	-0.9	-1.0
Conditioned reinforcement - actives	0.7	1.2	3.9	1.6	-2.0	-0.3	-0.1	0.7	0.3
Conditioned reinforcement - inactives	2.2	3.2	6.9	2.2	-2.6	0.6	-1.2	2.0	1.3
Conditioned locomotion	2.3	2.9	6.9	1.5	-2.6	1.2	-1.1	2.1	1.2
Patch foraging indifference point 0 sec	0.8	1.5	6.0	1.3	0.2	-2.5	-1.0	-0.3	0.4
Patch foraging indifference point AUC	0.4	0.6	1.5	1.0	-0.9	-1.2	-0.2	-0.0	-0.1
Delay disc. indifference point, 0s delay	1.6	1.7	5.8	2.4	-1.6	-1.1	-0.5	0.3	0.4
Delay disc. indifference point, 16s delay	3.3	3.7	6.6	2.6	-1.7	-1.0	-2.2	1.3	2.2
Delay disc. indifference point, 2s delay	2.1	2.4	4.3	1.8	-1.2	-0.6	-2.1	1.1	2.0
Delay disc. indifference point, 24s delay	3.0	3.3	7.3	2.7	-1.8	-1.2	-1.8	1.2	1.8
Delay disc. indifference point, 4s delay	1.0	1.1	3.4	1.9	-1.1	-1.3	0.1	-0.2	-0.2
Delay disc. indifference point, 8s delay	1.1	1.3	3.2	1.2	-0.1	-0.9	-1.8	0.2	1.6
Indifference point function ln k	0.1	0.2	0.3	-0.4	0.6	0.5	0.6	-0.1	-0.5
Indifference point function log k	0.1	0.2	0.3	-0.4	0.6	0.5	0.6	-0.1	-0.5
Patch foraging total patch changes 0 sec	0.7	1.4	6.0	1.1	0.4	-2.5	-0.8	-0.4	0.2
Patch foraging total patch changes 12 sec	0.6	0.8	1.5	1.1	-0.7	-1.2	-1.0	0.3	0.8
Patch foraging total patch changes 18 sec	0.3	0.4	1.8	0.5	-0.3	-1.4	-0.1	-0.4	-0.1
Patch foraging total patch changes 24 sec	0.9	1.6	7.0	1.3	-0.1	-2.7	-0.5	-0.6	0.2
Patch foraging total patch changes 6 sec	1.2	1.8	4.7	2.1	-0.8	-2.2	-1.0	0.3	0.4
Patch foraging time to switch 0 sec	0.6	1.2	2.7	-1.6	0.8	0.5	1.3	-1.0	-0.9
Patch foraging water rate 0 sec	0.6	1.3	2.4	1.4	-0.4	-0.4	-1.5	1.2	1.3
Patch foraging water rate 12 sec	0.4	0.9	1.7	1.3	-0.1	-1.0	-1.2	0.4	1.0
Patch foraging water rate 18 sec	0.1	0.2	0.7	0.8	-0.1	-0.5	-0.3	0.2	0.4
Patch foraging water rate 24 sec	1.4	1.9	5.9	2.4	-1.4	-1.1	-0.9	0.5	1.2
Patch foraging water rate 6 sec	0.2	0.3	0.6	0.1	0.2	0.3	-0.7	0.6	0.8
Seeking ratio, delayed vs. immediate footshock	0.4	0.4	1.1	-0.7	0.2	0.5	1.0	-0.4	-0.8
Distance traveled before self-admin	0.5	0.6	2.0	-1.4	1.1	0.7	0.2	-0.4	-0.1
Distance traveled after self-admin	0.8	0.9	3.1	-0.3	-0.8	1.8	-0.7	1.0	0.5
Extensor digitorum longus weight	0.2	0.7	1.8	0.4	-0.8	0.3	1.2	-0.4	-1.3
Bone: elastic displacement	2.0	2.3	3.6	-1.9	1.5	1.6	-1.4	0.9	1.6
Bone: elastic work	2.7	3.6	6.6	-1.1	0.3	2.6	-2.0	2.1	2.2
Bone: endosteal estimation	2.4	5.3	10.1	3.2	-3.0	-0.1	-1.8	2.5	1.7
Bone: endosteal perimeter	1.2	2.6	4.6	2.0	-2.1	0.8	-1.2	2.0	1.1
Epididymis fat weight	0.4	1.4	3.8	1.9	-1.8	-0.9	0.1	0.5	-0.3
Delta time in closed arm before/after self-admin	1.2	1.2	3.3	-0.9	1.8	-1.2	0.4	-1.1	-0.3
Delta time in open arm before/after self-admin	0.9	0.9	2.3	0.7	-1.5	1.2	-0.2	1.0	0.2
Diff in mean of infusions in LGA sessions	1.9	2.3	4.2	-2.0	1.2	0.3	1.6	-1.3	-1.9
Delay discount exponential model param	2.4	2.7	5.9	-2.4	1.3	1.3	1.8	-0.7	-1.7
Extinction: sum of active levers before priming	0.1	0.1	0.2	0.2	0.1	-0.3	0.3	-0.4	-0.3
Active lever presses in extinction session 6	0.6	0.6	1.1	0.8	-1.0	-0.5	0.9	-0.4	-1.1
Bone: final force	1.2	2.0	6.9	2.6	-1.7	-1.2	-0.6	0.6	0.1
Bone: final moment	1.5	2.4	7.4	2.7	-1.7	-1.0	-1.2	1.1	0.7
Food consumed during 24 hour testing period	0.4	0.6	2.0	0.4	0.2	-1.4	0.3	-0.7	-0.9
Glucose	0.0	0.0	0.1	0.1	-0.2	-0.0	-0.1	0.3	-0.1
Heart weight	0.5	0.7	1.8	0.8	-0.4	-0.4	-1.3	0.8	1.1
Delay discount hyperbolic model param	2.2	2.4	4.8	-2.2	1.1	1.1	1.9	-0.7	-1.7
Intermittent access intake day 1-15 change	0.0	0.1	0.3	0.6	-0.2	0.1	-0.2	0.4	0.3
Intermittent access intake escalation	0.1	0.2	0.5	0.7	-0.5	0.5	-0.0	0.5	0.2
Intermittent access intake escalation 2	0.3	0.3	1.0	-0.5	0.1	1.0	0.5	0.1	-0.4
Intermitt. access day 1 inactive lever presses	0.0	0.1	0.2	0.1	-0.1	0.4	-0.2	0.4	0.2
Intermitt. access day 15 inactive lever presses	1.0	2.1	3.0	1.2	-1.7	1.5	-1.2	1.7	1.1
Intermitt. access escalation Index	0.2	0.3	0.9	-0.4	0.5	0.3	0.6	-0.2	-0.9
Intermittent access day 1 total infusions	0.6	0.9	3.6	1.1	-1.9	0.2	0.3	0.7	-0.3
Intermittent access day 15 total infusions	0.8	1.3	3.6	1.7	-1.9	0.3	0.4	0.9	-0.4
Intermittent access terminal intake (last 3 days)	0.9	1.2	3.4	1.2	-1.9	0.9	0.4	1.0	-0.3
Intermittent access total infusions	0.9	1.0	3.2	1.1	-1.8	0.6	0.6	0.8	-0.6
Intermittent access day 1 locomotion	0.6	0.7	2.2	0.3	-1.5	0.2	1.0	0.3	-1.0
Intermittent access day 15 total locomotion	0.9	1.6	4.5	1.1	-2.1	1.1	-0.2	1.6	0.3
Intermittent access total locomotion	1.0	1.2	4.2	0.7	-2.1	0.9	0.6	1.1	-0.4
Intermittent access standard deviation	0.1	0.2	0.4	0.7	-0.6	0.1	0.1	0.3	-0.1
Left kidney weight	0.6	2.6	6.4	1.2	-0.1	-2.5	1.5	-1.5	-1.8
Right kidney weight	1.3	5.9	14.7	1.2	0.0	-3.8	2.3	-2.3	-2.9
Cocaine induced anxiety	0.0	0.0	0.1	0.3	0.1	-0.2	-0.1	-0.1	-0.2
Post-drug Anxiety	0.6	0.6	1.6	0.2	-0.0	0.8	-1.3	0.8	0.9
Baseline Anxiety	1.2	1.4	2.3	0.3	-0.5	1.5	-1.4	1.3	1.5
Tail length	1.6	6.2	17.5	3.9	-1.9	-4.2	-0.7	-0.2	-0.2
Length with tail	2.2	9.4	25.1	5.0	-2.5	-4.9	-0.2	-0.5	-0.5
Length without tail	1.4	4.5	11.1	3.3	-2.5	-2.6	0.9	-0.3	-1.2
Times rat made contact with spout	0.6	0.7	1.4	0.5	-0.4	-1.1	0.8	-0.7	-1.2
Lifetime Intake	0.7	0.8	2.6	1.0	-1.6	0.6	0.5	0.7	-0.4
Liver weight, left	0.3	0.4	1.0	1.0	-0.4	-1.0	0.3	-0.0	-0.6
Liver weight, right	0.3	0.5	1.0	0.6	-0.2	-1.0	0.9	-0.5	-0.8
Locomotor activity	1.2	1.8	2.8	-1.0	1.7	-1.2	1.4	-1.5	-1.2
Locomotor testing distance	2.5	4.4	6.3	-2.1	2.5	-1.5	2.1	-2.4	-1.9
Locomotor testing rearing	1.5	2.9	4.1	-1.5	1.6	-1.1	2.0	-2.0	-1.8
Locomotion in novel chamber	0.6	0.8	3.5	-0.5	-0.4	1.9	0.2	0.9	-0.2
Locomotion in novel chamber post-restriction	0.5	0.7	1.8	-0.6	0.4	0.1	1.1	-0.9	-1.3
Fecal boli incidents, locomotor time 1	0.3	0.4	1.5	0.3	-1.2	0.5	0.1	0.7	-0.2
Change in fecal boli incidents, locomotor task	1.0	1.0	1.5	-0.5	1.2	-0.8	0.9	-1.2	-1.1
Time >=10cm from walls, locomotor time 1	0.6	0.6	1.8	1.1	-1.4	-0.2	0.4	0.1	-0.7
Bouts of movement, locomotor time 1	1.1	1.3	2.5	0.3	0.3	-1.4	1.6	-1.4	-1.1
Total resting periods, locomotor time 1	1.2	1.3	2.7	1.1	-0.5	-1.6	1.3	-1.0	-0.9
Rest time, locomotor task time 1	0.1	0.2	0.5	0.1	-0.4	-0.7	0.4	-0.3	-0.2
Distance moved, locomotor task time 1	0.5	0.7	1.7	-0.2	1.3	-0.8	0.6	-0.9	-0.8
Vertical activity count, locomotor time 1	0.3	0.8	2.0	-1.0	1.4	0.2	0.5	-0.7	-0.9
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.5	0.7	-0.2	-0.3	-0.4	-0.0	0.5
Bouts of movement, locomotor time 2	0.3	0.4	1.4	0.4	0.6	-1.2	0.3	-0.7	0.4
Total resting periods, locomotor time 2	0.4	0.7	2.4	0.7	0.5	-1.6	0.4	-0.8	0.3
Rest time, locomotor task time 2	1.4	1.7	3.5	0.5	-0.5	-1.9	1.4	-1.2	-1.7
Distance moved, locomotor task time 2	0.6	0.7	3.0	-0.9	1.7	0.6	0.1	-0.4	0.4
Vertical activity count, locomotor time 2	0.8	1.1	3.2	-1.2	1.8	0.9	-0.7	-0.2	0.8
Light reinforcement 1	0.2	0.5	1.2	0.1	0.6	-0.6	-1.1	0.3	1.1
Light reinforcement 2	1.3	2.0	4.7	-0.4	1.1	0.7	-2.1	0.9	2.2
Bone: marrow area	2.5	5.6	10.4	3.2	-3.1	0.0	-1.9	2.6	1.8
Bone: maximum diameter	3.5	6.5	12.1	3.5	-3.5	0.8	-2.0	2.8	1.7
Bone: maximum force	2.0	3.6	9.6	3.1	-2.2	-0.7	-1.7	1.7	1.0
Bone: maximum moment	2.5	4.4	10.0	3.2	-2.1	-0.6	-2.2	2.0	1.6
Mean time between licks in bursts	0.8	1.9	5.0	-2.2	2.1	1.0	0.2	-0.7	-0.3
Mean num. licks in bursts	5.7	8.9	12.8	3.1	-3.3	1.3	-3.0	3.6	3.0
Cd content in liver	0.4	0.4	0.9	-0.5	0.7	-0.3	-0.9	0.1	1.0
Co content in liver	0.5	0.5	1.4	-1.2	0.7	1.0	-0.3	0.3	0.5
Cu content in liver	0.4	0.4	1.4	-0.6	1.2	-0.6	-0.2	-0.6	0.3
Fe content in liver	2.1	2.5	3.4	-1.8	1.8	-0.7	1.6	-1.7	-1.6
K content in liver	0.4	0.4	0.7	-0.6	0.7	0.3	0.8	-0.5	-0.7
Mg content in liver	0.4	0.5	0.8	-0.7	0.8	0.3	0.9	-0.6	-0.7
Mn content in liver	2.5	2.8	3.8	-1.7	1.9	-0.3	1.9	-1.8	-1.8
Na content in liver	1.3	1.3	2.1	-0.9	1.3	-0.4	1.5	-1.1	-1.4
Rb content in liver	0.4	0.4	1.1	0.4	0.3	-0.7	0.6	-0.7	-1.0
Se content in liver	12.9	15.3	29.3	-4.8	5.4	-2.0	2.8	-4.3	-3.0
Sr content in liver	1.3	1.1	3.1	-1.4	0.7	1.8	-0.5	0.5	0.7
Zn content in liver	1.6	1.8	4.5	-1.7	2.1	-0.6	0.9	-1.4	-0.7
Bone: minimum diameter	1.6	3.0	8.7	3.0	-2.4	-0.3	-0.8	1.6	0.4
Time in familiar zone, hab. session 1	0.1	0.1	0.4	0.4	-0.6	0.3	0.1	0.2	0.1
Time in novel zone, hab. session 1	1.8	1.8	4.2	-1.8	2.0	-0.4	0.7	-1.3	-0.8
Total zone transitions, hab. session 1	0.1	0.2	0.3	0.2	-0.6	-0.4	0.4	-0.3	-0.5
Total locomotion distance, hab. session 1	0.2	0.3	0.4	-0.0	-0.1	-0.5	0.7	-0.6	-0.7
Locomotion velocity, hab. session 1	0.2	0.2	0.4	0.3	-0.5	-0.4	0.6	-0.3	-0.6
Time in familiar zone, hab. session 2	0.9	1.0	2.2	0.5	-0.2	0.7	-1.5	0.9	1.5
Time in novel zone, hab. session 2	0.4	0.4	0.8	-0.9	0.5	-0.2	0.7	-0.4	-0.8
Total zone transitions, hab. session 2	0.1	0.2	0.6	0.0	0.1	-0.8	0.2	-0.6	-0.3
Total locomotion distance, hab. session 2	0.2	0.3	0.7	-0.6	0.5	-0.3	0.5	-0.8	-0.5
Locomotion velocity, hab. session 2	0.3	0.4	0.9	-0.6	0.4	-0.4	0.7	-1.0	-0.7
Novel to familiar place preference ratio	0.4	0.5	1.2	-0.3	0.4	-0.4	1.0	-0.6	-1.1
Novelty place preference	0.3	0.3	1.0	-0.2	0.2	-0.2	0.9	-0.4	-1.0
Time in novel zone, NPP test	0.7	0.7	1.7	-0.5	0.7	-0.2	1.2	-0.7	-1.3
Total zone transitions, NPP test	0.2	0.3	1.2	0.2	0.0	-1.1	0.0	-0.6	-0.3
Total locomotion distance, NPP test	0.0	0.1	0.1	-0.4	0.2	-0.3	-0.2	-0.3	0.1
Locomotion velocity, NPP test	0.0	0.1	0.2	-0.2	0.0	-0.4	-0.0	-0.4	-0.0
Intraocular pressure	0.4	0.5	1.3	0.7	0.0	-0.0	-1.2	0.6	1.0
Delta distance traveled before/after self-admin	1.3	1.4	3.2	0.8	-1.8	1.3	-0.8	1.4	0.5
Delta ambulatory time before/after self-admin	2.1	2.6	6.0	1.3	-2.4	1.4	-1.2	1.9	0.9
Parametrial fat weight	1.3	3.1	7.5	0.5	0.5	-2.7	1.5	-2.2	-1.9
Pavlov. Cond. lever latency	0.1	0.2	0.4	-0.2	-0.2	0.5	-0.3	0.4	0.6
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	0.2	0.4	-0.4	-0.2	-0.3	-0.1
Pavlov. Cond. change in total contacts	0.5	0.5	1.1	-0.3	1.0	-0.9	0.3	-0.8	-0.7
Pavlov. Cond. index score	0.3	0.4	0.9	0.2	0.6	-1.0	0.3	-0.8	-0.6
Pavlov. Cond. latency score	0.3	0.4	1.1	0.4	0.4	-1.0	0.3	-0.7	-0.7
Pavlov. Cond. lever contacts	0.4	0.4	0.7	-0.1	0.8	-0.8	0.4	-0.8	-0.7
Pavlov. Cond. magazine entry number	0.1	0.1	0.4	-0.1	-0.6	0.3	0.4	0.1	-0.0
Pavlov. Cond. intertrial magazine entries	0.5	0.6	1.6	1.3	-1.0	-0.8	-0.0	0.3	0.2
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.7	-0.0	0.8	-0.8	0.4	-0.8	-0.7
Pavlov. Cond. response bias	0.2	0.3	1.0	-0.2	1.0	-0.5	-0.1	-0.5	-0.3
Pavlov. Cond. lever latency	0.7	1.0	2.7	-0.9	0.0	0.6	1.6	-0.7	-1.3
Pavlov. Cond. magazine entry latency	0.5	0.6	1.5	-0.5	1.2	-1.1	-0.2	-0.7	-0.2
Pavlov. Cond. change in total contacts	0.2	0.3	0.8	0.9	-0.0	-0.9	-0.6	0.0	0.3
Pavlov. Cond. index score	0.3	0.5	1.5	0.6	0.4	-1.2	-0.8	-0.1	0.4
Pavlov. Cond. latency score	0.4	0.5	1.2	0.8	0.2	-1.1	-0.9	0.1	0.5
Pavlov. Cond. lever contacts	0.7	0.9	2.5	0.9	-0.2	-0.4	-1.6	0.8	1.2
Pavlov. Cond. magazine entry number	0.5	0.6	2.3	0.1	-0.9	1.5	0.1	0.7	0.3
Pavlov. Cond. intertrial magazine entries	1.1	1.7	3.6	0.1	0.1	-1.3	1.9	-1.5	-1.7
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	1.5	0.4	0.6	-1.2	-0.6	-0.3	0.3
Pavlov. Cond. response bias	0.5	0.7	1.9	0.6	0.5	-1.4	-1.1	0.0	0.7
Time in closed arm before self-admin	1.1	1.4	2.9	-1.2	0.8	-0.2	1.3	-1.2	-1.7
Time in closed arm after self-admin	1.4	1.5	3.0	-1.2	1.7	-1.1	0.7	-1.5	-0.9
Time in open arm before self-admin	0.2	0.3	0.6	-0.6	0.8	0.2	-0.7	0.2	0.4
Time in open arm after self-admin	0.4	0.4	1.1	0.8	-1.0	0.6	-0.1	0.7	0.1
Bone: periosteal estimation	3.1	6.6	15.8	4.0	-3.3	-0.3	-2.0	2.5	1.6
Bone: periosteal perimeter	1.2	2.1	6.7	2.6	-2.1	-0.4	-0.5	1.1	0.1
Bone: post-yield work	1.8	2.6	8.1	2.5	-1.1	-2.8	-0.4	-0.1	0.1
Progressive ratio test 1 active lever presses	2.5	3.0	7.3	1.7	-2.7	1.3	-0.9	2.1	1.0
Progressive ratio test 1 breakpoint	2.1	2.6	6.5	1.6	-2.5	1.2	-0.8	1.9	0.9
Progressive ratio test 1 inactive lever presses	1.8	2.5	5.1	2.1	-2.3	-0.0	-1.2	1.6	1.2
Progressive ratio test 2 active lever presses	1.3	1.5	5.5	1.4	-2.3	0.5	0.5	1.1	-0.2
Progressive ratio test 2 breakpoint	1.6	1.8	6.4	1.6	-2.5	0.6	0.2	1.3	0.0
Progressive ratio test 2 inactive lever presses	0.6	1.0	3.5	0.9	-1.9	0.8	0.4	1.0	-0.3
Incentive Sensitization - Responses	0.5	0.7	1.3	0.8	-1.1	-0.7	1.1	-0.1	-0.7
Incentive Sensitization - Breakpoint	0.6	0.7	1.8	1.1	-1.3	-0.6	0.9	0.1	-0.5
Sum of active levers in priming session hrs 5-6	0.4	0.4	0.7	-0.7	0.8	-0.5	0.3	-0.8	-0.5
Progressive ratio	0.1	0.1	0.3	0.3	0.1	-0.5	0.2	-0.4	-0.4
Food seeking constrained by brief footshock	1.2	1.4	3.1	-0.7	0.7	-0.5	1.8	-1.4	-1.5
Seeking ratio, punishment vs. effort	0.6	0.9	1.4	-1.0	1.0	-0.5	1.0	-1.2	-0.8
Retroperitoneal fat weight	0.3	1.2	2.4	-0.1	0.4	-1.6	1.2	-1.3	-1.3
Reaction time number correct	1.2	2.3	4.7	1.7	-0.6	0.1	-2.0	1.4	2.2
Reaction time mean minus median	0.1	0.3	0.6	-0.7	0.5	0.8	-0.5	0.4	0.4
Reaction time mean minus median AUC	0.2	0.5	1.0	-0.6	0.4	0.7	-1.0	0.6	0.9
Reaction time num false alarms	1.0	1.4	2.4	-0.2	0.7	-1.1	1.4	-1.5	-1.6
Reaction time num false alarms AUC	1.3	2.0	3.3	-0.4	1.1	-1.4	1.4	-1.8	-1.8
Reaction time trials correct on left	1.2	2.3	4.7	1.7	-0.6	0.1	-2.0	1.4	2.2
Reaction time trials on left	1.2	2.2	4.7	1.6	-0.5	0.1	-2.0	1.3	2.2
Reaction time mean	0.5	0.7	2.2	-1.5	1.1	0.6	0.6	-0.5	-0.3
Reaction time mean AUC	0.5	0.8	2.5	-1.6	1.1	0.9	0.3	-0.3	-0.1
Median of all reaction times	0.6	0.9	2.6	-1.6	1.1	0.8	0.7	-0.6	-0.3
Reaction time omissions	0.4	0.6	1.6	-1.3	1.2	0.5	-0.3	-0.4	0.4
Reaction time false alarm rate	2.7	3.7	7.3	-1.1	1.1	-1.2	2.4	-2.3	-2.7
Reaction time premature initiation rate	0.9	1.3	1.9	1.1	-1.2	-1.3	1.3	-0.4	-1.4
Reaction time premature initiations	0.8	1.4	4.3	2.1	-1.5	-1.2	-0.1	0.5	0.0
Std. dev. reaction times	0.2	0.4	1.3	-1.1	1.1	0.3	-0.2	-0.3	0.2
Reaction time trials completed	1.2	2.2	4.7	1.6	-0.5	0.1	-2.0	1.3	2.2
Reaction time trials AUC	1.1	2.1	4.9	1.5	-0.4	0.1	-2.0	1.3	2.2
Run reversals in cocaine runway, females	0.5	0.5	1.0	0.0	-0.4	0.4	-0.9	0.8	1.0
Run reversals in cocaine runway, males	1.9	1.9	2.9	-0.6	1.0	-1.4	1.6	-1.7	-1.7
Latency to leave start box in cocaine runway	0.6	0.7	1.5	-1.1	0.3	1.2	0.8	0.0	-0.8
Latency to leave start box in cocaine runway, F	1.5	1.7	3.5	-1.9	1.1	0.8	1.4	-0.9	-1.4
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	0.4	-0.4	0.4	0.2	0.5	-0.1
Std. dev. time between licks in bursts	1.9	2.5	7.0	-2.6	2.6	0.7	0.0	-0.9	0.1
Total sessions with >9 infusions	0.5	0.6	1.5	1.2	-1.2	-0.5	-0.1	0.3	0.4
Short access day 1 total inactive lever presses	1.1	1.4	3.3	1.1	-1.8	1.3	-0.4	1.4	0.3
Short access day 10 total inactive lever presses	0.4	1.0	3.1	1.8	-1.0	-1.3	-0.2	-0.1	-0.2
Short access day 1 total infusions	0.4	0.5	1.7	1.0	-1.3	0.1	0.2	0.4	-0.2
Short access day 10 total infusions	0.4	0.5	0.8	0.6	-0.9	0.6	-0.7	0.9	0.7
Short access total infusions	0.8	1.0	2.4	1.3	-1.5	0.5	-0.5	1.0	0.7
Short access day 1 locomotion	0.1	0.1	0.2	0.0	-0.5	0.3	0.3	0.2	-0.5
Short access day 10 total locomotion	0.2	0.4	0.9	-1.0	-0.0	0.4	0.8	-0.2	-0.7
Short access total locomotion	0.2	0.2	0.4	-0.6	-0.2	0.4	0.7	-0.0	-0.6
One hour access (0.3 mA shock)	2.7	3.1	7.1	2.2	-2.7	0.8	-1.1	1.9	1.1
Compulsive drug intake	0.3	0.4	0.8	0.9	-0.6	-0.5	-0.7	0.5	0.4
One hour access (shock baseline)	0.1	0.2	0.6	0.1	-0.5	0.2	0.7	-0.0	-0.6
Social response proportion	0.6	0.7	3.1	-0.4	-0.5	1.8	0.2	0.9	0.1
Social responses	0.2	0.2	0.8	-0.2	-0.3	0.9	-0.0	0.5	-0.2
Social time	0.2	0.2	0.5	-0.1	0.7	-0.7	-0.0	-0.5	-0.2
Soleus weight	0.5	1.5	3.4	0.4	-1.0	1.8	-1.3	1.3	1.0
Bone: stiffness	1.3	2.0	7.0	2.6	-1.7	-1.4	-0.4	0.4	-0.1
Tibialis anterior weight	0.4	1.2	3.5	1.3	-1.9	0.5	0.8	0.5	-0.8
Time to tail flick, vehicle, before self-admin	0.4	0.4	1.1	-0.5	-0.0	1.0	-0.6	0.8	0.4
Time to tail flick, vehicle, after self-admin	1.4	1.8	7.2	1.3	-0.2	-2.7	0.6	-1.1	-0.6
Time to tail flick, test, before self-admin	0.5	0.6	1.7	0.1	-0.6	1.3	-0.5	0.8	0.6
Time to tail flick, test, after self-admin	0.6	0.6	1.6	0.4	-0.6	-0.2	-0.9	0.7	1.3
Delta time to tail flick, vehicle, before/after SA	2.9	2.8	7.7	1.8	-0.9	-2.8	1.3	-1.3	-1.3
Delta time to tail flick, test, before/after SA	0.2	0.2	1.3	-0.1	0.1	-1.1	0.3	-0.3	-0.0
Tibia length	1.0	2.8	8.4	2.9	-1.9	-1.8	-0.8	0.7	0.3
Ambulatory time before self-admin	0.7	1.0	3.3	-1.8	1.4	0.6	0.4	-0.6	-0.2
Ambulatory time after self-admin	1.0	1.2	5.0	-0.7	-1.0	2.2	0.1	0.9	-0.1
Bone: tissue strength	0.1	0.1	0.6	0.0	0.3	-0.7	-0.4	0.2	0.2
Total heroin consumption	1.5	1.7	3.3	0.8	-0.3	-1.5	1.7	-1.1	-1.8
Bone: trabecular number	2.3	3.7	6.9	2.6	-2.1	0.1	-2.1	1.9	1.7
Bone: trabecular spacing	1.5	2.0	3.0	-0.9	1.0	-1.6	1.5	-1.7	-1.5
Bone: trabecular thickness	2.6	3.3	5.5	2.3	-1.8	0.7	-2.0	1.7	1.9
Bone: trabecular tissue density	0.7	1.0	2.0	0.9	-1.4	1.4	-0.2	1.1	0.5
Water consumed over 24 hours	1.1	1.4	2.7	0.1	0.6	-1.3	1.3	-1.4	-1.6
Number of responses in last shaping day	0.9	1.0	1.9	1.3	-1.1	0.4	-0.9	1.4	0.6