Kcnn1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL alternative TSS XM_063275662.1 0.02 0.02 5.5e-03 0.01 0.02 0.01 0.01 1.8e-02 1.4e-03 1.1e-02 8.0e-03
2 Liver gene expression Kcnn1 0.19 0.07 0.0e+00 0.22 0.23 0.22 0.23 1.7e-23 1.4e-25 5.1e-24 5.0e-25
3 PL isoform ratio XM_063275658.1 0.04 0.03 9.0e-04 0.04 0.02 0.03 0.03 8.3e-05 1.3e-03 4.4e-04 4.7e-04
4 NAcc alternative TSS XM_063275666.1 0.03 0.02 3.6e-06 0.04 0.03 0.03 0.03 2.1e-06 1.3e-05 2.1e-05 2.6e-05
5 Brain isoform ratio XM_063275658.1 0.03 0.02 7.1e-03 0.01 0.02 0.02 0.01 2.2e-02 4.0e-03 8.3e-03 1.4e-02
6 NAcc alternative TSS XM_063275660.1 0.02 0.02 1.3e-03 0.02 0.02 0.02 0.02 8.7e-04 9.7e-04 5.3e-04 4.7e-04
7 NAcc isoform ratio XM_063275658.1 0.02 0.01 1.5e-03 0.01 0.01 0 0.01 1.6e-02 1.7e-02 2.1e-01 3.7e-02
8 BLA intron excision ratio chr16_18613158_18613961 0.08 0.06 5.7e-03 0.03 0.03 0.02 0.03 1.8e-02 7.3e-03 3.1e-02 1.3e-02
9 PL alternative TSS XM_063275666.1 0.04 0.02 4.9e-05 0.04 0.04 0.04 0.04 2.7e-05 1.2e-05 2.9e-05 2.8e-05
10 Brain alternative TSS XM_063275660.1 0.06 0.04 3.5e-06 0.07 0.05 0.04 0.05 9.3e-07 1.2e-05 1.1e-04 2.0e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density0.50.91.9-1.40.70.70.70.7-0.81.2-0.60.8-1.2
Area under the delay curve0.10.10.20.5-0.4-0.4-0.5-0.30.30.10.1-0.10.1
BMI with tail1.75.99.5-2.83.12.22.42.7-2.41.9-2.42.2-1.9
BMI without tail3.310.014.0-3.53.72.82.93.4-3.02.9-3.33.1-2.8
Body weight5.323.131.5-5.65.64.44.75.2-4.74.3-4.64.5-4.3
Weight adjusted by age2.23.34.1-2.02.01.61.81.9-1.72.0-1.81.7-1.7
Bone surface0.20.30.7-0.80.60.50.50.5-0.60.5-0.20.3-0.5
Bone volume0.81.42.4-1.61.21.11.11.2-1.21.3-0.91.0-1.2
Breakpoint value in progressive ratio session0.10.10.30.00.4-0.6-0.10.20.2-0.20.3-0.40.3
Number of licking bursts0.10.10.20.4-0.5-0.2-0.3-0.40.3-0.20.3-0.30.2
Context. condit. distance diff. score0.10.10.2-0.3-0.10.50.3-0.1-0.00.3-0.00.1-0.4
Locomotion velocity, session 10.50.61.90.10.4-0.6-0.4-0.10.6-1.40.7-0.91.1
Locomotion distance, session 12.12.64.01.2-1.1-1.5-1.5-1.41.6-2.01.8-1.91.9
Locomotion velocity, session 21.21.43.4-1.51.80.60.71.5-0.90.9-1.31.1-1.0
Locomotion distance, session 22.63.74.41.5-1.4-2.1-2.1-1.72.0-2.12.0-2.12.1
Locomotion velocity, session 30.30.30.60.3-0.3-0.7-0.7-0.50.8-0.50.5-0.60.3
Locomotion distance, session 30.60.61.00.6-0.8-0.6-0.6-0.80.8-0.91.0-0.90.8
Stereotopy head waving bouts, day 30.30.40.70.3-0.8-0.6-0.7-0.80.8-0.40.8-0.70.3
Stereotopy head waving duration, day 30.00.00.1-0.1-0.3-0.1-0.2-0.20.3-0.00.2-0.1-0.2
Locomotion velocity, session 71.21.41.71.3-1.2-1.0-1.0-1.21.3-1.11.2-1.21.3
Locomotion distance, session 71.62.02.91.7-1.6-1.2-1.3-1.51.3-1.21.4-1.31.5
Stereotopy head waving bouts, day 70.10.10.7-0.90.50.10.10.4-0.10.1-0.10.2-0.4
Stereotopy head waving duration, day 70.70.82.0-1.41.20.70.61.0-0.60.7-0.80.8-1.1
Locomotion velocity, session 81.01.32.00.7-0.6-1.1-1.2-1.01.4-1.21.2-1.31.2
Locomotion distance, session 80.71.01.60.6-0.7-0.9-0.9-0.91.1-1.21.2-1.21.1
Degree of sensitization distance0.30.30.80.9-0.6-0.5-0.5-0.60.4-0.20.3-0.30.5
Degree of sensitization stereotypy0.40.41.2-1.10.80.60.60.7-0.50.3-0.40.4-0.5
Conditioned locomotion0.10.10.20.3-0.40.30.3-0.2-0.2-0.50.2-0.10.2
Cocaine response after cond. corrected0.30.41.00.1-0.60.60.6-0.1-0.51.0-0.40.6-0.9
Cocaine response after cond. not corrected0.10.10.60.5-0.8-0.0-0.1-0.50.20.40.10.0-0.3
Cocaine response before conditioning1.31.52.60.9-0.3-1.6-1.5-0.81.5-1.41.1-1.31.4
Saline control response0.10.20.4-0.00.0-0.6-0.5-0.30.5-0.30.4-0.50.4
Bone: connectivity density0.20.30.6-0.80.50.60.60.5-0.70.4-0.30.4-0.7
Bone: cortical apparent density0.20.30.90.4-0.0-0.9-0.9-0.30.7-0.30.2-0.30.2
Bone: cortical area6.610.213.6-3.73.33.03.03.4-3.33.1-3.03.0-2.8
Bone: cortical porosity0.20.30.90.30.0-0.3-0.3-0.10.4-0.80.6-0.60.9
Bone: cortical porosity0.20.20.70.20.0-0.2-0.2-0.10.3-0.80.6-0.60.9
Bone: cortical thickness4.27.010.9-3.32.72.62.62.7-2.82.6-2.32.4-2.4
Bone: cortical thickness2.22.64.2-2.00.92.11.81.3-1.71.8-1.11.4-1.6
Bone: cortical tissue density0.30.41.10.6-0.2-1.0-1.0-0.40.8-0.50.3-0.40.3
Condit. Reinf. active minus inactive responses0.20.30.8-0.90.40.60.60.5-0.50.4-0.20.3-0.3
Condit. Reinf. active-inactive response ratio0.20.20.4-0.60.00.60.50.3-0.60.6-0.20.4-0.5
Condit. Reinf. active responses0.40.51.3-1.10.80.80.80.8-0.70.5-0.40.4-0.5
Condit. Reinf. inactive responses0.30.40.8-0.70.90.60.70.7-0.50.4-0.50.4-0.3
Incentive salience index mean0.40.51.7-1.31.10.50.60.9-0.60.3-0.40.3-0.4
Condit. Reinf. lever presses0.50.72.6-1.51.60.30.41.2-0.6-0.0-0.40.3-0.2
Condit. Reinf. active minus inactive responses0.20.30.40.3-0.2-0.6-0.5-0.40.6-0.40.5-0.60.6
Condit. Reinf. active-inactive response ratio0.30.40.6-0.80.70.60.60.7-0.70.6-0.60.6-0.5
Condit. Reinf. active responses1.11.62.31.1-0.8-1.5-1.4-1.11.5-1.11.2-1.31.4
Condit. Reinf. inactive responses2.53.24.12.0-1.4-2.0-1.9-1.72.0-1.61.6-1.71.8
Condit. Reinf. lever presses0.10.10.4-0.20.6-0.1-0.00.40.00.3-0.40.3-0.2
Condit. Reinf. lever reinforcers received0.30.40.80.6-0.3-0.9-0.8-0.50.8-0.40.5-0.60.7
Conditioned reinforcement - actives1.62.74.7-1.51.42.21.81.6-1.91.3-1.61.6-1.4
Conditioned reinforcement - inactives7.911.613.8-3.43.03.73.43.4-3.73.3-3.33.5-3.3
Conditioned locomotion2.22.95.5-1.41.22.32.01.4-1.91.6-1.71.7-1.6
Patch foraging indifference point 0 sec2.74.96.3-2.32.52.22.32.3-2.12.1-2.22.1-2.1
Patch foraging indifference point AUC0.10.10.30.30.2-0.6-0.5-0.10.4-0.1-0.1-0.0-0.2
Delay disc. indifference point, 0s delay2.62.83.91.7-1.6-1.9-2.0-1.71.8-1.41.5-1.51.5
Delay disc. indifference point, 16s delay0.70.81.91.4-1.1-1.0-0.9-1.00.8-0.40.6-0.60.7
Delay disc. indifference point, 2s delay0.91.01.80.8-0.8-1.1-1.3-0.91.1-0.91.0-1.00.8
Delay disc. indifference point, 24s delay0.20.20.5-0.20.40.30.10.4-0.30.7-0.70.6-0.5
Delay disc. indifference point, 4s delay0.10.10.2-0.10.1-0.4-0.5-0.10.5-0.10.1-0.20.0
Delay disc. indifference point, 8s delay0.20.20.70.00.1-0.00.20.3-0.20.8-0.60.6-0.6
Indifference point function ln k0.61.02.2-0.90.61.51.50.9-1.30.6-0.70.9-0.4
Indifference point function log k0.61.02.2-0.90.61.51.50.9-1.30.6-0.70.9-0.4
Patch foraging total patch changes 0 sec4.07.69.2-2.93.02.72.82.9-2.72.6-2.72.6-2.6
Patch foraging total patch changes 12 sec1.01.32.2-1.21.40.80.81.1-0.71.3-1.31.2-1.5
Patch foraging total patch changes 18 sec0.00.00.00.20.1-0.1-0.0-0.10.1-0.1-0.0-0.1-0.1
Patch foraging total patch changes 24 sec0.30.51.0-0.70.71.01.00.7-0.70.6-0.60.6-0.8
Patch foraging total patch changes 6 sec1.82.84.4-1.82.11.31.41.7-1.11.9-1.71.6-1.8
Patch foraging time to switch 0 sec1.22.44.41.4-1.2-2.1-2.0-1.51.8-1.01.4-1.51.4
Patch foraging water rate 0 sec1.12.22.9-1.71.71.51.51.7-1.51.0-1.51.4-1.3
Patch foraging water rate 12 sec0.30.71.4-0.90.71.21.20.9-1.10.4-0.70.7-0.4
Patch foraging water rate 18 sec0.20.30.90.3-0.2-0.1-0.1-0.20.3-0.90.6-0.61.0
Patch foraging water rate 24 sec0.20.30.7-0.80.70.50.50.6-0.5-0.3-0.30.20.1
Patch foraging water rate 6 sec1.52.34.1-1.41.22.02.01.5-1.81.0-1.41.4-1.0
Seeking ratio, delayed vs. immediate footshock0.70.91.60.6-0.5-1.2-1.1-0.91.3-0.90.6-0.71.1
Distance traveled before self-admin0.81.12.1-1.21.50.40.71.2-0.71.1-1.11.0-1.0
Distance traveled after self-admin1.21.42.9-1.51.70.51.11.5-0.91.2-1.11.1-1.0
Extensor digitorum longus weight0.41.62.8-1.71.70.91.01.3-0.91.3-1.31.2-1.2
Bone: elastic displacement0.40.40.70.3-0.4-0.8-0.8-0.50.8-0.60.7-0.70.7
Bone: elastic work1.82.43.5-1.91.61.41.31.6-1.41.6-1.51.5-1.5
Bone: endosteal estimation0.10.20.40.00.30.50.50.4-0.60.4-0.60.5-0.3
Bone: endosteal perimeter1.02.23.4-1.21.31.81.81.5-1.81.3-1.41.5-1.1
Epididymis fat weight0.62.14.7-1.72.20.91.01.8-1.31.1-1.61.4-1.2
Delta time in closed arm before/after self-admin0.20.20.60.10.10.50.30.1-0.20.8-0.40.3-0.5
Delta time in open arm before/after self-admin1.11.13.00.9-0.7-1.7-1.3-0.81.2-1.00.9-0.90.8
Diff in mean of infusions in LGA sessions1.31.63.2-1.21.80.51.01.4-0.81.6-1.41.2-1.2
Delay discount exponential model param0.00.00.1-0.10.20.10.20.1-0.1-0.40.1-0.10.2
Extinction: sum of active levers before priming1.01.12.50.7-0.4-1.6-1.5-0.71.2-0.81.0-1.11.0
Active lever presses in extinction session 60.20.20.50.4-0.2-0.7-0.6-0.40.6-0.10.3-0.40.4
Bone: final force8.413.515.4-3.93.73.63.63.8-3.83.5-3.63.6-3.5
Bone: final moment7.912.814.3-3.73.53.63.63.7-3.83.5-3.53.5-3.4
Food consumed during 24 hour testing period0.50.71.10.5-0.5-0.9-0.9-0.70.9-0.91.0-1.01.0
Glucose1.42.23.7-1.51.91.31.31.8-1.51.1-1.51.4-1.3
Heart weight1.52.33.9-2.01.31.81.91.4-1.41.6-1.11.2-1.2
Delay discount hyperbolic model param0.00.00.1-0.10.10.20.20.1-0.1-0.30.1-0.10.2
Intermittent access intake day 1-15 change0.10.10.3-0.50.20.50.50.4-0.60.1-0.20.3-0.2
Intermittent access intake escalation0.00.00.1-0.2-0.10.20.20.0-0.2-0.20.1-0.1-0.0
Intermittent access intake escalation 20.30.40.5-0.70.70.30.40.7-0.60.6-0.70.6-0.6
Intermitt. access day 1 inactive lever presses0.10.40.7-0.70.60.80.60.6-0.70.5-0.60.7-0.6
Intermitt. access day 15 inactive lever presses0.10.10.5-0.0-0.20.70.6-0.0-0.4-0.20.10.00.2
Intermitt. access escalation Index0.50.71.10.9-1.1-0.8-0.8-1.00.8-0.40.8-0.70.9
Intermittent access day 1 total infusions1.11.83.3-0.80.91.81.81.1-1.51.2-1.31.3-1.4
Intermittent access day 15 total infusions0.30.41.1-0.40.20.71.00.5-0.90.4-0.50.6-0.6
Intermittent access terminal intake (last 3 days)0.30.41.0-0.20.20.71.00.5-0.90.6-0.50.6-0.5
Intermittent access total infusions1.51.82.7-1.01.01.31.61.2-1.51.4-1.31.4-1.5
Intermittent access day 1 locomotion2.63.35.8-1.31.52.42.11.7-2.11.6-1.71.7-1.8
Intermittent access day 15 total locomotion0.20.30.8-0.20.30.90.90.4-0.90.3-0.30.4-0.5
Intermittent access total locomotion2.63.14.3-1.41.52.11.91.6-1.91.8-1.61.6-1.9
Intermittent access standard deviation0.20.40.5-0.60.50.60.70.6-0.70.7-0.70.7-0.6
Left kidney weight0.52.35.0-1.92.21.11.21.8-1.31.2-1.51.3-1.3
Right kidney weight1.25.711.7-2.73.41.61.82.8-2.02.0-2.52.2-2.0
Cocaine induced anxiety1.72.53.5-1.41.71.61.91.5-1.41.9-1.51.4-1.5
Post-drug Anxiety0.10.10.6-0.30.40.00.40.3-0.10.7-0.30.2-0.1
Baseline Anxiety3.84.47.01.8-1.9-2.6-2.5-2.02.1-1.91.9-1.82.0
Tail length0.93.65.4-2.22.31.31.42.1-1.62.0-2.01.9-1.8
Length with tail2.08.612.4-3.53.52.42.53.3-2.72.8-2.92.7-2.8
Length without tail1.55.07.3-2.72.32.22.22.4-2.22.1-1.92.0-2.2
Times rat made contact with spout0.30.40.40.6-0.5-0.6-0.6-0.60.6-0.60.6-0.60.6
Lifetime Intake2.93.54.9-1.51.42.22.21.7-2.11.9-1.81.8-1.8
Liver weight, left0.61.02.00.5-0.3-1.4-1.4-0.71.1-1.00.9-1.01.0
Liver weight, right1.22.04.3-1.62.10.70.91.7-1.21.2-1.61.4-1.3
Locomotor activity0.20.30.8-0.40.4-0.9-0.90.10.6-0.40.4-0.50.5
Locomotor testing distance0.40.71.20.3-0.5-1.1-1.1-0.61.0-0.80.8-0.90.8
Locomotor testing rearing0.51.01.60.6-0.3-1.3-1.2-0.71.1-1.01.1-1.21.0
Locomotion in novel chamber0.10.10.2-0.40.4-0.2-0.30.3-0.10.3-0.10.1-0.2
Locomotion in novel chamber post-restriction0.10.10.4-0.1-0.1-0.1-0.3-0.1-0.0-0.30.7-0.60.5
Fecal boli incidents, locomotor time 10.20.30.50.7-0.7-0.7-0.4-0.50.6-0.40.3-0.30.4
Change in fecal boli incidents, locomotor task0.30.30.40.6-0.4-0.4-0.6-0.40.3-0.70.4-0.50.5
Time >=10cm from walls, locomotor time 10.00.00.10.30.0-0.10.3-0.00.00.2-0.20.1-0.1
Bouts of movement, locomotor time 10.50.60.90.8-0.3-0.8-1.0-0.60.8-1.00.7-0.70.9
Total resting periods, locomotor time 11.11.21.81.2-0.7-1.0-1.2-1.01.1-1.31.0-1.11.3
Rest time, locomotor task time 10.00.00.10.3-0.3-0.00.0-0.20.3-0.30.00.00.2
Distance moved, locomotor task time 10.00.00.10.1-0.1-0.3-0.2-0.1-0.10.20.1-0.1-0.1
Vertical activity count, locomotor time 10.10.21.0-0.20.3-0.9-1.00.10.30.30.0-0.10.0
Time >=10cm from walls, locomotor time 20.60.92.11.0-1.5-0.7-0.5-1.20.9-0.60.8-0.80.7
Bouts of movement, locomotor time 20.10.10.30.1-0.0-0.3-0.4-0.20.5-0.50.4-0.50.3
Total resting periods, locomotor time 20.00.00.1-0.00.0-0.1-0.1-0.10.3-0.30.3-0.30.2
Rest time, locomotor task time 20.40.50.8-0.80.90.40.30.9-0.50.8-0.80.8-0.6
Distance moved, locomotor task time 20.10.20.60.6-0.8-0.2-0.1-0.60.1-0.10.3-0.20.3
Vertical activity count, locomotor time 20.10.10.2-0.2-0.4-0.3-0.2-0.30.30.40.1-0.0-0.2
Light reinforcement 10.00.00.10.20.20.0-0.00.2-0.2-0.1-0.30.2-0.1
Light reinforcement 20.30.51.2-0.00.40.30.30.4-0.41.1-0.90.9-1.0
Bone: marrow area0.10.10.30.10.20.40.40.3-0.50.3-0.40.4-0.2
Bone: maximum diameter3.15.86.9-2.62.22.62.62.4-2.62.4-2.22.3-2.1
Bone: maximum force7.012.416.0-4.03.83.43.43.8-3.63.4-3.43.3-3.1
Bone: maximum moment6.210.813.3-3.63.43.23.23.5-3.43.2-3.13.1-2.9
Mean time between licks in bursts1.63.85.1-2.12.31.61.72.2-2.01.9-2.12.0-1.6
Mean num. licks in bursts0.00.00.0-0.10.0-0.00.10.1-0.1-0.00.1-0.00.1
Cd content in liver1.71.92.8-1.20.51.61.51.1-1.71.7-1.21.5-1.3
Co content in liver0.00.00.0-0.10.1-0.0-0.00.1-0.10.1-0.00.0-0.2
Cu content in liver1.82.23.51.1-1.3-1.1-1.2-1.41.3-1.91.8-1.81.6
Fe content in liver0.91.12.11.1-1.0-1.4-1.4-1.01.0-0.90.9-0.90.8
K content in liver2.22.13.01.6-1.7-1.2-1.3-1.61.3-1.31.5-1.41.4
Mg content in liver0.10.10.30.3-0.50.10.0-0.40.2-0.40.4-0.30.2
Mn content in liver0.10.10.2-0.20.10.50.40.2-0.3-0.30.1-0.00.2
Na content in liver3.73.94.41.8-1.6-2.1-2.1-1.92.1-2.12.0-2.12.1
Rb content in liver2.32.64.0-1.30.62.01.91.2-1.81.9-1.41.7-1.8
Se content in liver0.30.40.60.4-0.6-0.4-0.5-0.60.6-0.80.8-0.70.6
Sr content in liver0.40.30.60.7-0.3-0.8-0.8-0.50.6-0.50.4-0.50.4
Zn content in liver0.10.10.20.20.0-0.3-0.4-0.10.3-0.50.3-0.30.3
Bone: minimum diameter2.13.85.2-2.12.31.61.72.2-2.02.0-2.01.9-1.6
Time in familiar zone, hab. session 10.10.10.3-0.30.60.10.20.5-0.30.0-0.40.3-0.3
Time in novel zone, hab. session 10.00.00.1-0.0-0.40.20.1-0.20.00.10.1-0.0-0.1
Total zone transitions, hab. session 10.71.01.50.8-0.6-1.1-1.0-0.81.0-1.21.0-1.11.1
Total locomotion distance, hab. session 12.13.04.61.4-1.2-1.8-1.8-1.41.7-2.11.8-1.91.9
Locomotion velocity, hab. session 12.02.94.51.5-1.1-1.8-1.8-1.41.7-2.11.7-1.82.0
Time in familiar zone, hab. session 20.10.10.2-0.20.40.30.40.3-0.40.3-0.30.3-0.2
Time in novel zone, hab. session 20.00.00.10.1-0.3-0.1-0.2-0.10.10.10.00.1-0.1
Total zone transitions, hab. session 20.20.20.50.4-0.4-0.1-0.1-0.40.3-0.70.6-0.50.7
Total locomotion distance, hab. session 20.40.51.00.4-0.6-0.4-0.4-0.60.7-1.01.0-0.91.0
Locomotion velocity, hab. session 20.60.81.30.5-0.6-0.7-0.7-0.70.9-1.11.1-1.11.2
Novel to familiar place preference ratio0.10.10.4-0.00.10.0-0.00.2-0.30.4-0.50.5-0.6
Novelty place preference0.10.10.20.1-0.1-0.0-0.10.1-0.20.2-0.30.4-0.4
Time in novel zone, NPP test0.10.10.20.4-0.4-0.3-0.4-0.20.1-0.0-0.00.1-0.1
Total zone transitions, NPP test1.01.52.41.0-1.0-0.9-1.0-1.11.2-1.61.4-1.41.4
Total locomotion distance, NPP test2.23.04.11.4-1.4-1.4-1.5-1.61.8-2.02.0-2.02.0
Locomotion velocity, NPP test2.02.83.81.4-1.4-1.5-1.5-1.61.8-2.01.9-1.91.9
Intraocular pressure1.52.23.0-1.51.11.41.31.4-1.51.5-1.61.7-1.7
Delta distance traveled before/after self-admin0.40.51.2-0.91.1-0.20.31.0-0.50.5-0.70.7-0.6
Delta ambulatory time before/after self-admin0.10.10.2-0.40.5-0.10.10.5-0.30.2-0.30.3-0.2
Parametrial fat weight3.58.210.8-2.52.92.62.83.0-2.82.6-3.33.2-2.8
Pavlov. Cond. lever latency0.20.20.80.8-0.90.50.4-0.3-0.30.1-0.10.3-0.1
Pavlov. Cond. magazine entry latency0.20.30.5-0.60.70.20.30.5-0.20.7-0.60.5-0.5
Pavlov. Cond. change in total contacts1.21.32.8-1.71.60.60.61.2-0.71.3-1.11.0-1.1
Pavlov. Cond. index score0.10.10.4-0.50.6-0.6-0.50.20.40.00.0-0.20.1
Pavlov. Cond. latency score0.20.20.6-0.50.6-0.8-0.60.10.6-0.10.2-0.40.2
Pavlov. Cond. lever contacts0.20.31.2-0.91.1-0.5-0.30.50.20.1-0.2-0.0-0.0
Pavlov. Cond. magazine entry number0.30.40.90.7-0.9-0.3-0.4-0.70.3-0.70.7-0.60.6
Pavlov. Cond. intertrial magazine entries0.10.10.5-0.2-0.70.30.1-0.40.1-0.10.7-0.50.3
Pavlov. Cond. lever-magazine prob. diff.0.10.10.4-0.50.7-0.4-0.30.20.30.1-0.1-0.10.0
Pavlov. Cond. response bias0.20.20.7-0.70.80.10.20.5-0.20.5-0.40.3-0.3
Pavlov. Cond. lever latency0.91.32.61.3-1.6-0.3-0.4-1.20.6-1.31.3-1.11.2
Pavlov. Cond. magazine entry latency0.81.01.7-1.11.30.30.51.0-0.61.3-1.11.0-1.2
Pavlov. Cond. change in total contacts0.81.32.5-1.41.60.50.61.2-0.71.4-1.31.1-1.2
Pavlov. Cond. index score1.41.93.4-1.61.80.60.81.5-0.91.7-1.61.4-1.6
Pavlov. Cond. latency score0.91.22.2-1.21.50.20.41.1-0.61.4-1.21.1-1.3
Pavlov. Cond. lever contacts0.71.02.2-1.21.50.30.41.1-0.51.2-1.21.0-1.1
Pavlov. Cond. magazine entry number2.12.64.21.8-2.1-0.8-0.9-1.71.2-1.91.8-1.61.7
Pavlov. Cond. intertrial magazine entries1.11.72.91.5-1.4-0.7-0.7-1.21.0-1.61.4-1.41.7
Pavlov. Cond. lever-magazine prob. diff.1.62.13.7-1.71.90.60.81.5-1.01.8-1.71.5-1.6
Pavlov. Cond. response bias1.21.63.2-1.41.80.60.71.4-0.91.4-1.51.3-1.3
Time in closed arm before self-admin6.68.410.6-3.33.22.43.03.1-2.52.8-3.02.9-2.8
Time in closed arm after self-admin6.46.88.5-2.42.22.72.82.4-2.42.9-2.72.8-2.7
Time in open arm before self-admin1.21.32.21.0-0.8-0.8-1.4-1.11.0-1.11.4-1.51.4
Time in open arm after self-admin2.93.24.41.2-1.2-1.8-2.1-1.61.7-2.02.0-2.11.9
Bone: periosteal estimation2.04.15.1-2.12.02.02.02.1-2.32.0-2.02.0-1.7
Bone: periosteal perimeter5.39.110.9-3.12.83.23.23.1-3.32.9-2.82.9-2.6
Bone: post-yield work0.10.10.20.3-0.4-0.0-0.1-0.20.1-0.30.4-0.30.5
Progressive ratio test 1 active lever presses3.74.57.5-1.92.02.72.52.0-2.22.1-1.91.8-2.0
Progressive ratio test 1 breakpoint3.44.16.9-1.81.92.62.41.9-2.11.9-1.81.7-1.9
Progressive ratio test 1 inactive lever presses1.62.32.8-1.61.51.71.61.6-1.61.2-1.51.4-1.4
Progressive ratio test 2 active lever presses1.11.21.9-0.80.81.21.41.0-1.21.2-1.11.1-1.2
Progressive ratio test 2 breakpoint0.80.91.4-0.60.71.01.20.8-1.01.0-0.91.0-1.0
Progressive ratio test 2 inactive lever presses1.32.13.8-1.31.11.82.01.4-1.71.3-1.21.3-1.2
Incentive Sensitization - Responses0.10.10.20.5-0.5-0.30.3-0.1-0.10.1-0.10.2-0.1
Incentive Sensitization - Breakpoint0.10.10.60.7-0.7-0.50.0-0.40.1-0.10.10.00.1
Sum of active levers in priming session hrs 5-64.94.65.82.1-2.4-1.9-2.3-2.21.9-1.82.3-2.22.1
Progressive ratio0.00.10.20.3-0.4-0.2-0.2-0.30.10.00.1-0.00.3
Food seeking constrained by brief footshock0.40.41.60.6-1.3-0.3-0.2-0.80.3-0.30.9-0.60.5
Seeking ratio, punishment vs. effort0.30.40.70.5-0.7-0.5-0.5-0.60.5-0.70.8-0.80.5
Retroperitoneal fat weight2.912.514.2-3.73.73.43.53.7-3.53.1-3.83.7-3.2
Reaction time number correct0.30.51.30.20.1-0.6-0.6-0.30.5-1.10.8-0.91.1
Reaction time mean minus median0.00.00.20.10.3-0.4-0.20.00.2-0.20.1-0.20.2
Reaction time mean minus median AUC0.00.00.1-0.10.30.20.40.2-0.2-0.1-0.0-0.00.1
Reaction time num false alarms0.81.11.6-1.01.01.21.11.1-1.10.8-0.91.0-1.2
Reaction time num false alarms AUC0.50.71.2-0.80.80.90.80.9-0.90.7-0.80.8-1.1
Reaction time trials correct on left0.30.51.30.20.1-0.6-0.6-0.30.5-1.10.8-0.91.1
Reaction time trials on left0.20.41.20.10.2-0.6-0.5-0.20.5-1.10.7-0.81.1
Reaction time mean0.91.42.0-0.81.01.01.11.1-1.21.4-1.41.4-1.3
Reaction time mean AUC0.30.40.7-0.20.60.50.60.6-0.70.8-0.90.8-0.7
Median of all reaction times1.21.72.7-0.80.91.21.21.1-1.41.6-1.51.5-1.5
Reaction time omissions1.11.63.3-1.21.80.91.01.6-1.30.9-1.31.1-1.1
Reaction time false alarm rate1.01.42.5-1.00.81.31.11.1-1.21.2-1.11.3-1.6
Reaction time premature initiation rate0.30.40.90.3-0.3-0.4-0.3-0.50.5-0.80.9-0.90.9
Reaction time premature initiations0.30.61.40.20.0-0.5-0.4-0.30.5-1.10.9-1.11.2
Std. dev. reaction times0.30.51.2-0.61.10.40.50.9-0.80.5-0.80.7-0.7
Reaction time trials completed0.20.41.20.10.2-0.6-0.5-0.20.5-1.10.7-0.81.1
Reaction time trials AUC0.10.30.8-0.00.3-0.4-0.4-0.00.3-0.90.5-0.60.9
Run reversals in cocaine runway, females4.24.25.6-2.01.92.32.12.1-2.41.9-1.92.0-1.8
Run reversals in cocaine runway, males1.61.62.21.3-1.0-1.1-1.1-1.21.2-1.41.4-1.41.5
Latency to leave start box in cocaine runway0.00.00.20.10.10.00.40.1-0.1-0.5-0.10.00.1
Latency to leave start box in cocaine runway, F0.20.30.5-0.60.60.50.70.6-0.6-0.0-0.40.4-0.3
Latency to leave start box in cocaine runway, M0.40.41.01.0-0.8-0.6-0.2-0.80.6-0.60.4-0.40.5
Std. dev. time between licks in bursts2.02.83.3-1.81.81.41.51.8-1.71.6-1.71.7-1.5
Total sessions with >9 infusions6.27.515.8-2.42.34.03.02.5-3.22.3-2.42.4-2.4
Short access day 1 total inactive lever presses2.12.85.4-1.30.82.32.11.3-2.01.6-1.51.7-1.3
Short access day 10 total inactive lever presses0.00.10.30.3-0.2-0.2-0.3-0.40.5-0.20.3-0.40.4
Short access day 1 total infusions4.35.89.1-2.42.13.02.42.3-2.72.2-2.22.3-2.1
Short access day 10 total infusions1.51.95.6-1.10.82.41.81.1-1.70.9-1.01.1-1.0
Short access total infusions3.24.19.0-1.71.63.02.31.8-2.51.8-1.81.8-1.7
Short access day 1 locomotion7.99.812.9-3.12.73.63.33.0-3.22.9-3.13.1-3.2
Short access day 10 total locomotion1.52.85.4-1.81.62.32.01.6-1.91.3-1.21.2-1.2
Short access total locomotion4.15.09.9-2.11.83.12.62.0-2.61.9-1.81.9-2.0
One hour access (0.3 mA shock)0.60.61.0-0.60.10.90.90.5-0.90.9-0.80.9-1.0
Compulsive drug intake1.31.52.31.4-1.5-1.3-1.3-1.31.1-1.11.1-1.01.0
One hour access (shock baseline)2.53.84.6-1.81.62.02.11.8-2.02.2-1.92.0-2.0
Social response proportion2.42.73.8-1.91.21.71.61.5-1.61.9-1.31.5-1.9
Social responses0.10.10.5-0.70.20.0-0.10.3-0.10.40.10.0-0.3
Social time0.10.10.3-0.5-0.00.2-0.00.2-0.10.4-0.00.2-0.4
Soleus weight1.13.34.2-1.51.81.71.81.9-1.91.7-2.02.0-1.8
Bone: stiffness5.89.411.8-3.43.33.03.03.2-3.13.0-2.92.9-2.7
Tibialis anterior weight0.10.20.9-0.81.0-0.10.00.5-0.20.1-0.20.1-0.0
Time to tail flick, vehicle, before self-admin0.30.31.20.4-0.41.11.0-0.0-0.8-0.10.00.10.1
Time to tail flick, vehicle, after self-admin0.20.30.6-0.60.80.50.20.5-0.30.7-0.70.5-0.5
Time to tail flick, test, before self-admin2.62.73.9-1.61.32.01.71.5-1.61.7-1.41.6-1.9
Time to tail flick, test, after self-admin0.50.51.81.1-1.30.1-0.6-0.90.2-0.10.7-0.50.5
Delta time to tail flick, vehicle, before/after SA0.10.10.3-0.20.2-0.4-0.5-0.10.6-0.00.0-0.20.2
Delta time to tail flick, test, before/after SA1.71.72.71.6-1.5-1.1-1.3-1.41.0-1.21.2-1.21.5
Tibia length0.71.92.8-1.71.41.41.51.4-1.41.5-1.21.3-1.2
Ambulatory time before self-admin1.21.73.7-1.61.90.10.81.6-0.71.4-1.51.3-1.3
Ambulatory time after self-admin2.02.45.2-2.02.30.31.21.9-1.01.5-1.51.4-1.4
Bone: tissue strength0.10.10.5-0.20.70.10.10.5-0.20.1-0.40.3-0.1
Total heroin consumption0.10.10.4-0.20.6-0.2-0.40.5-0.20.3-0.30.2-0.3
Bone: trabecular number0.71.12.1-1.41.10.80.81.0-0.91.2-0.80.9-1.3
Bone: trabecular spacing0.10.10.30.5-0.3-0.4-0.4-0.30.2-0.40.2-0.20.4
Bone: trabecular thickness0.40.51.1-1.10.70.70.70.7-0.60.7-0.50.5-0.7
Bone: trabecular tissue density0.60.91.70.8-0.4-1.0-0.9-0.71.0-1.00.9-1.01.3
Water consumed over 24 hours0.00.10.2-0.00.1-0.1-0.1-0.00.1-0.50.3-0.40.3
Number of responses in last shaping day0.20.20.8-0.50.10.90.60.4-0.80.2-0.20.3-0.0