Kcnj15

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	IC	gene expression	Kcnj15	0.17	0.12	1.1e-03	0.01	0.03	0.05	0.02	1.4e-01	2.6e-02	3.3e-03	7.1e-02
2	Adipose	alternative TSS	XM_006248135.4	0.04	0.03	2.5e-03	0.02	0.01	0.01	0.01	3.5e-03	4.0e-02	1.8e-02	2.1e-02
3	Liver	mRNA stability	Kcnj15	0.14	0.08	1.5e-13	0.09	0.1	0.1	0.11	7.9e-10	1.1e-11	2.2e-11	7.7e-12
4	NAcc	gene expression	Kcnj15	0.02	0.02	7.1e-03	0.01	0.01	0.01	0.01	3.4e-02	5.6e-03	9.5e-03	1.6e-02
5	OFC	gene expression	Kcnj15	0.19	0.11	1.6e-03	0.1	0.16	0.07	0.14	2.7e-03	1.6e-04	1.1e-02	4.4e-04
6	PL	gene expression	Kcnj15	0.11	0.09	9.0e-03	0	0.01	0.02	0.01	2.2e-01	1.9e-02	1.7e-03	9.1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.4	0.6	1.2	-0.5	-1.1	1.1	-0.7	-0.6	-0.6
Area under the delay curve	1.0	1.2	2.8	-0.9	0.6	-0.6	-1.0	-1.7	-1.4
BMI with tail	0.2	0.7	1.5	-0.9	-1.0	0.7	-0.8	-1.2	-0.0
BMI without tail	0.2	0.6	2.1	-0.1	0.3	-0.9	-0.3	-1.4	0.4
Body weight	0.2	0.8	1.7	1.3	0.5	-1.1	1.0	-0.1	0.9
Weight adjusted by age	1.5	2.2	3.2	1.1	1.7	-1.7	1.8	0.4	1.7
Bone surface	1.7	3.2	6.9	-1.3	-2.6	1.7	-1.4	-0.8	-2.2
Bone volume	1.7	3.0	6.1	-1.3	-2.5	1.9	-1.5	-0.9	-1.9
Breakpoint value in progressive ratio session	1.8	2.2	7.3	2.7	-0.2	-0.4	1.8	1.3	0.9
Number of licking bursts	0.1	0.2	0.7	-0.1	0.2	-0.1	-0.6	-0.8	-0.2
Context. condit. distance diff. score	0.5	0.6	1.4	1.2	0.9	-0.1	0.7	0.8	0.2
Locomotion velocity, session 1	0.2	0.2	0.8	-0.0	-0.5	0.9	-0.4	0.3	-0.1
Locomotion distance, session 1	0.7	0.8	2.1	0.4	-1.1	1.5	-0.6	0.5	-1.0
Locomotion velocity, session 2	0.4	0.4	1.5	1.2	-0.2	-0.1	0.6	0.7	0.2
Locomotion distance, session 2	0.3	0.4	0.8	0.8	-0.6	0.3	-0.4	-0.3	-0.9
Locomotion velocity, session 3	1.2	1.4	3.4	0.0	-1.7	1.9	-0.7	1.1	-0.3
Locomotion distance, session 3	0.2	0.2	0.5	0.4	-0.7	-0.5	0.4	-0.2	0.4
Stereotopy head waving bouts, day 3	1.4	1.7	4.4	-2.1	-0.8	1.7	-1.4	0.4	0.1
Stereotopy head waving duration, day 3	1.7	2.0	4.1	-2.0	-1.0	1.9	-1.7	0.2	-0.3
Locomotion velocity, session 7	1.4	1.5	2.1	1.3	1.3	-1.3	1.4	0.6	1.3
Locomotion distance, session 7	2.1	2.7	6.7	1.5	1.8	-2.6	1.8	-0.2	0.8
Stereotopy head waving bouts, day 7	1.4	1.5	4.3	-0.4	-1.6	2.1	-0.6	1.3	0.4
Stereotopy head waving duration, day 7	1.3	1.5	4.0	0.4	-1.4	2.0	-0.2	1.7	0.5
Locomotion velocity, session 8	0.7	0.8	2.3	-0.1	-1.2	1.5	-0.6	0.9	-0.1
Locomotion distance, session 8	0.3	0.5	2.3	1.5	0.3	0.0	0.2	0.3	-0.6
Degree of sensitization distance	0.8	0.8	3.3	0.2	1.8	-1.1	0.7	0.1	0.2
Degree of sensitization stereotypy	1.1	1.2	3.4	0.3	-1.6	1.8	-0.5	1.0	-0.1
Conditioned locomotion	1.4	1.6	4.1	2.0	1.0	-0.8	1.2	0.8	1.3
Cocaine response after cond. corrected	0.6	0.8	2.9	1.7	0.0	0.4	0.5	1.2	0.0
Cocaine response after cond. not corrected	0.9	1.0	3.7	1.9	0.4	-0.3	0.9	1.2	0.1
Cocaine response before conditioning	0.2	0.2	0.5	-0.2	0.1	-0.6	-0.1	-0.5	-0.7
Saline control response	0.7	0.9	1.9	0.8	-0.9	1.0	0.7	1.4	0.8
Bone: connectivity density	0.9	1.5	3.1	-0.8	-1.8	1.1	-1.1	-1.0	-1.4
Bone: cortical apparent density	0.8	1.1	1.8	-0.9	-1.0	1.3	-1.1	-0.3	-1.3
Bone: cortical area	0.4	0.6	2.0	0.7	0.0	-0.1	1.0	1.4	0.1
Bone: cortical porosity	0.2	0.2	0.4	-0.2	0.3	0.3	-0.7	-0.5	-0.6
Bone: cortical porosity	0.1	0.1	0.3	-0.0	0.4	0.2	-0.5	-0.3	-0.5
Bone: cortical thickness	1.7	2.8	4.2	1.7	1.7	-1.3	2.0	1.9	1.1
Bone: cortical thickness	0.4	0.5	1.0	0.8	0.5	-0.6	1.0	0.6	0.7
Bone: cortical tissue density	0.9	1.3	1.9	-1.0	-1.1	1.4	-1.2	-0.4	-1.4
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	0.0	0.3	-0.4	0.3	0.2	0.2
Condit. Reinf. active-inactive response ratio	1.0	1.1	2.0	0.7	1.0	-0.7	1.3	1.0	1.4
Condit. Reinf. active responses	0.2	0.2	1.1	0.0	-0.4	0.2	-0.4	-0.2	-1.0
Condit. Reinf. inactive responses	0.8	1.0	2.4	-0.1	-1.2	1.0	-1.1	-0.2	-1.5
Incentive salience index mean	0.2	0.3	1.1	0.3	0.6	-1.0	0.5	0.0	-0.0
Condit. Reinf. lever presses	0.3	0.4	0.9	0.5	0.9	-1.0	0.4	0.1	-0.3
Condit. Reinf. active minus inactive responses	0.3	0.4	1.2	0.1	-0.5	0.8	-0.4	0.1	-1.1
Condit. Reinf. active-inactive response ratio	0.5	0.6	1.3	-0.6	0.2	-0.1	-0.8	-1.1	-1.1
Condit. Reinf. active responses	0.5	0.7	1.9	0.5	-0.8	1.4	0.2	1.3	0.1
Condit. Reinf. inactive responses	1.1	1.5	3.9	0.8	-0.9	1.3	0.9	2.0	1.0
Condit. Reinf. lever presses	0.2	0.2	0.5	0.4	-0.1	-0.4	0.7	0.7	0.0
Condit. Reinf. lever reinforcers received	0.5	0.6	1.4	0.6	-0.8	1.2	0.3	1.2	0.0
Conditioned reinforcement - actives	0.6	1.0	2.0	1.2	1.4	-1.4	0.7	0.1	0.0
Conditioned reinforcement - inactives	3.1	4.5	6.1	2.3	2.5	-2.3	2.2	1.8	1.6
Conditioned locomotion	0.7	0.9	1.5	1.2	0.8	-0.7	1.2	1.1	0.3
Patch foraging indifference point 0 sec	2.8	5.2	8.7	1.8	2.1	-1.4	3.0	2.6	2.4
Patch foraging indifference point AUC	0.9	1.3	2.6	1.5	-1.1	1.2	0.7	1.6	0.2
Delay disc. indifference point, 0s delay	1.1	1.2	2.1	-1.3	-0.3	0.4	-1.0	-1.4	-1.5
Delay disc. indifference point, 16s delay	0.4	0.5	1.4	-0.4	0.2	-0.2	-0.9	-1.2	-0.5
Delay disc. indifference point, 2s delay	1.1	1.2	2.4	-1.2	-0.2	0.1	-1.1	-1.5	-1.4
Delay disc. indifference point, 24s delay	0.9	1.0	1.8	0.0	0.9	-1.1	-0.9	-1.2	-1.3
Delay disc. indifference point, 4s delay	1.1	1.1	2.0	-1.4	-0.0	-0.1	-0.9	-1.4	-1.4
Delay disc. indifference point, 8s delay	0.7	0.8	2.1	-0.3	1.4	-1.1	-0.2	-0.8	-0.8
Indifference point function ln k	0.3	0.5	1.4	-0.4	1.2	-1.0	0.1	-0.5	-0.1
Indifference point function log k	0.3	0.5	1.4	-0.4	1.2	-1.0	0.1	-0.5	-0.1
Patch foraging total patch changes 0 sec	2.6	4.8	8.5	1.7	1.8	-1.1	2.9	2.6	2.5
Patch foraging total patch changes 12 sec	2.3	2.9	6.8	1.5	-0.1	0.3	2.2	2.6	1.9
Patch foraging total patch changes 18 sec	0.9	1.4	4.3	1.4	-0.4	1.0	1.0	2.1	0.4
Patch foraging total patch changes 24 sec	0.2	0.4	1.3	0.5	0.1	0.4	0.9	1.2	0.0
Patch foraging total patch changes 6 sec	2.3	3.6	9.1	2.0	0.1	0.4	2.2	3.0	1.8
Patch foraging time to switch 0 sec	0.7	1.5	3.5	-1.0	-0.6	0.2	-1.9	-1.8	-1.1
Patch foraging water rate 0 sec	0.5	1.1	2.8	-0.3	-0.7	0.9	1.2	1.7	1.1
Patch foraging water rate 12 sec	0.9	1.9	4.0	1.0	2.0	-1.2	1.5	1.3	1.0
Patch foraging water rate 18 sec	0.1	0.2	0.9	-0.9	-0.1	0.0	0.1	-0.4	0.1
Patch foraging water rate 24 sec	1.1	1.5	3.1	1.3	1.2	-1.4	1.8	0.6	0.8
Patch foraging water rate 6 sec	0.1	0.2	0.6	-0.1	0.8	-0.6	0.5	0.2	-0.1
Seeking ratio, delayed vs. immediate footshock	1.1	1.3	2.2	-1.4	-0.9	0.6	-1.5	-1.4	-1.0
Distance traveled before self-admin	0.3	0.4	1.1	0.5	-0.3	0.6	0.6	1.1	0.6
Distance traveled after self-admin	0.5	0.6	1.4	-0.7	0.3	-1.0	0.1	-1.2	0.6
Extensor digitorum longus weight	3.6	14.1	22.4	-3.5	-4.7	4.7	-4.0	-1.5	-3.2
Bone: elastic displacement	0.2	0.2	0.8	-0.9	0.3	0.2	-0.3	-0.1	0.4
Bone: elastic work	0.2	0.3	1.2	-1.1	0.1	0.6	-0.4	0.2	0.1
Bone: endosteal estimation	1.3	2.9	4.6	-1.7	-2.2	1.6	-1.7	-1.3	-1.6
Bone: endosteal perimeter	0.4	0.9	2.2	-0.0	-1.5	1.3	-0.6	0.1	-1.2
Epididymis fat weight	0.1	0.4	1.0	0.4	-1.0	0.4	-0.3	-0.1	-0.9
Delta time in closed arm before/after self-admin	1.8	1.7	4.4	-1.8	-0.0	-0.3	-1.4	-2.1	-0.8
Delta time in open arm before/after self-admin	0.2	0.2	0.9	-0.1	0.0	-0.5	0.4	0.1	1.0
Diff in mean of infusions in LGA sessions	1.4	1.7	3.0	1.7	-1.3	1.6	0.5	1.7	0.0
Delay discount exponential model param	1.0	1.1	2.4	0.9	-0.6	0.4	1.0	1.5	1.4
Extinction: sum of active levers before priming	1.2	1.3	2.9	1.7	-0.0	0.1	1.4	1.5	1.0
Active lever presses in extinction session 6	2.1	2.1	4.7	0.6	0.7	-0.4	1.6	2.2	2.1
Bone: final force	0.3	0.5	1.3	0.4	0.2	-0.1	1.0	1.1	0.7
Bone: final moment	0.3	0.5	1.4	0.5	0.1	-0.0	1.0	1.2	0.6
Food consumed during 24 hour testing period	0.2	0.3	0.9	0.9	0.5	0.1	-0.2	0.5	-0.3
Glucose	2.3	3.6	8.0	-1.4	-2.8	2.6	-1.6	0.1	-1.6
Heart weight	0.6	0.9	1.9	-1.0	-0.2	-0.1	-1.1	-1.4	-1.0
Delay discount hyperbolic model param	0.9	1.0	2.2	0.9	-0.4	0.3	1.0	1.5	1.3
Intermittent access intake day 1-15 change	0.3	0.6	2.2	0.8	0.4	0.2	0.5	1.5	0.3
Intermittent access intake escalation	0.3	0.6	2.0	0.7	0.4	0.1	0.6	1.4	0.5
Intermittent access intake escalation 2	0.5	0.6	2.5	0.5	-0.0	0.4	0.7	1.6	0.1
Intermitt. access day 1 inactive lever presses	1.1	4.1	7.1	2.0	2.7	-2.5	2.0	1.1	1.5
Intermitt. access day 15 inactive lever presses	1.0	2.0	3.5	1.8	1.4	-1.1	1.5	1.9	0.2
Intermitt. access escalation Index	0.6	0.9	1.8	1.1	1.1	-1.4	0.9	0.1	0.7
Intermittent access day 1 total infusions	0.7	1.1	2.5	1.6	1.0	-1.2	1.3	0.5	-0.1
Intermittent access day 15 total infusions	1.8	2.6	3.9	2.0	1.7	-1.3	1.8	1.9	0.5
Intermittent access terminal intake (last 3 days)	1.7	2.2	3.2	1.8	1.6	-1.5	1.7	1.6	0.2
Intermittent access total infusions	2.1	2.5	3.5	1.8	1.7	-1.8	1.9	1.4	0.4
Intermittent access day 1 locomotion	1.5	1.9	3.8	1.7	1.7	-2.0	1.2	0.2	-0.3
Intermittent access day 15 total locomotion	1.1	2.0	4.3	1.9	1.0	-0.5	1.7	2.1	-0.1
Intermittent access total locomotion	3.5	4.2	7.9	2.8	2.1	-1.7	2.3	2.1	0.2
Intermittent access standard deviation	0.5	1.1	3.5	0.9	0.4	-0.1	1.1	1.9	0.9
Left kidney weight	1.0	4.6	11.4	2.3	2.9	-3.4	1.4	-0.9	0.4
Right kidney weight	1.0	4.7	9.7	2.6	3.1	-2.8	1.8	0.3	0.7
Cocaine induced anxiety	0.2	0.3	0.8	0.9	0.3	0.1	0.1	0.7	-0.8
Post-drug Anxiety	0.7	0.7	3.1	0.9	-0.3	0.4	-0.4	0.4	-1.8
Baseline Anxiety	0.8	0.9	1.9	-0.9	-0.5	0.2	-1.1	-1.4	-1.1
Tail length	1.2	4.8	7.2	2.6	2.4	-2.7	2.2	1.3	1.6
Length with tail	0.4	1.6	3.3	1.8	1.3	-1.6	1.2	0.7	0.4
Length without tail	0.0	0.2	0.6	0.3	-0.0	0.1	0.4	0.8	-0.3
Times rat made contact with spout	2.2	2.5	6.9	1.7	2.6	-1.6	1.1	1.0	1.0
Lifetime Intake	1.0	1.2	2.9	0.8	1.3	-1.7	1.4	0.5	0.3
Liver weight, left	3.4	5.6	8.9	1.7	3.0	-2.9	2.5	0.3	2.7
Liver weight, right	1.5	2.6	5.4	0.4	2.0	-1.6	1.8	0.3	2.3
Locomotor activity	3.1	4.9	9.0	1.7	3.0	-2.8	2.4	0.7	1.9
Locomotor testing distance	1.1	2.1	4.0	0.8	2.0	-1.8	1.6	0.7	1.2
Locomotor testing rearing	0.4	0.9	2.0	1.0	1.3	-1.4	0.7	-0.1	0.0
Locomotion in novel chamber	0.2	0.3	1.0	0.1	-0.2	0.4	-0.7	0.1	-1.0
Locomotion in novel chamber post-restriction	1.4	2.3	5.5	-2.3	-1.3	0.8	-1.8	-1.2	-1.2
Fecal boli incidents, locomotor time 1	0.6	0.8	1.7	-0.6	0.8	-0.9	-0.5	-1.3	-1.1
Change in fecal boli incidents, locomotor task	0.9	0.9	2.0	-0.8	1.3	-1.4	-0.4	-0.7	-0.4
Time >=10cm from walls, locomotor time 1	0.6	0.7	2.3	-0.2	1.5	-1.2	0.2	0.3	-0.3
Bouts of movement, locomotor time 1	0.4	0.5	1.1	0.3	-0.9	1.0	-0.8	0.1	-0.2
Total resting periods, locomotor time 1	0.2	0.3	0.6	0.8	-0.5	0.7	-0.3	0.4	0.2
Rest time, locomotor task time 1	0.2	0.2	0.4	0.6	-0.0	-0.0	-0.0	-0.6	-0.6
Distance moved, locomotor task time 1	0.3	0.4	1.4	-0.8	0.2	-0.2	0.3	0.5	1.2
Vertical activity count, locomotor time 1	0.1	0.3	0.5	-0.7	-0.1	0.2	0.3	0.7	0.7
Time >=10cm from walls, locomotor time 2	0.5	0.8	3.0	-1.7	-0.5	0.1	-0.8	-0.9	-0.4
Bouts of movement, locomotor time 2	0.5	0.7	2.4	0.8	-1.6	0.8	0.0	0.0	-0.8
Total resting periods, locomotor time 2	0.2	0.3	1.0	1.0	-0.8	0.1	0.4	0.1	-0.5
Rest time, locomotor task time 2	0.2	0.3	0.8	0.5	0.9	-0.1	-0.3	0.0	-0.7
Distance moved, locomotor task time 2	0.6	0.7	2.0	-1.4	-1.1	0.4	-0.2	-0.5	0.7
Vertical activity count, locomotor time 2	0.4	0.5	2.4	-1.5	-0.6	-0.1	0.0	-0.5	0.1
Light reinforcement 1	0.6	1.5	3.7	-0.7	-0.6	-0.3	-1.2	-1.7	-1.9
Light reinforcement 2	1.5	2.3	6.5	0.2	-2.0	1.0	-1.2	-0.9	-2.5
Bone: marrow area	1.5	3.2	5.1	-1.7	-2.3	1.7	-1.8	-1.4	-1.8
Bone: maximum diameter	0.3	0.5	0.9	0.2	-0.9	0.9	0.0	0.8	-0.7
Bone: maximum force	0.3	0.5	1.3	0.1	-0.4	0.6	0.7	1.1	0.7
Bone: maximum moment	0.2	0.4	1.2	0.2	-0.4	0.4	0.8	1.1	0.5
Mean time between licks in bursts	0.2	0.6	2.7	-0.3	1.6	-0.7	-0.1	-0.3	0.3
Mean num. licks in bursts	0.8	1.2	2.6	1.1	1.1	-0.5	1.2	1.6	1.0
Cd content in liver	0.9	1.0	3.5	-1.9	-0.8	-0.6	-0.6	-1.1	-0.3
Co content in liver	1.0	1.2	3.1	-0.6	-0.3	-0.3	-0.9	-1.6	-1.8
Cu content in liver	0.9	1.0	1.7	1.0	0.6	-1.2	1.3	0.6	1.1
Fe content in liver	0.7	0.8	2.2	0.8	-0.1	-0.2	0.9	1.5	1.2
K content in liver	0.1	0.1	0.1	-0.2	-0.1	-0.4	0.2	-0.3	0.2
Mg content in liver	0.1	0.1	0.3	-0.5	-0.5	0.0	-0.1	-0.4	-0.2
Mn content in liver	0.4	0.4	1.3	0.3	-0.6	0.2	-0.5	-0.5	-1.1
Na content in liver	0.7	0.7	3.0	0.2	-1.7	0.6	-0.4	0.3	-0.9
Rb content in liver	0.2	0.2	0.8	-0.1	0.5	-0.9	0.3	-0.4	0.1
Se content in liver	0.3	0.4	0.5	0.7	0.4	-0.7	0.5	0.6	0.6
Sr content in liver	0.7	0.6	1.5	0.7	1.2	-1.2	0.4	-0.3	0.0
Zn content in liver	0.2	0.3	1.2	-0.2	0.4	-1.1	0.3	-0.1	-0.0
Bone: minimum diameter	1.9	3.5	6.3	-2.1	-2.3	2.5	-1.6	-0.2	-1.5
Time in familiar zone, hab. session 1	0.7	0.7	2.1	-0.0	-0.3	0.9	-1.0	-0.4	-1.4
Time in novel zone, hab. session 1	0.6	0.6	2.0	-1.4	-0.6	0.1	-0.2	-0.6	0.8
Total zone transitions, hab. session 1	1.3	1.8	3.9	1.4	1.8	-2.0	1.3	0.3	-0.1
Total locomotion distance, hab. session 1	1.0	1.4	3.8	0.8	1.7	-1.9	1.1	0.0	0.2
Locomotion velocity, hab. session 1	1.2	1.7	4.0	1.2	1.6	-2.0	1.4	0.2	0.4
Time in familiar zone, hab. session 2	0.9	1.0	1.8	-0.6	-0.5	1.0	-1.3	-0.9	-1.3
Time in novel zone, hab. session 2	0.6	0.6	1.8	0.1	0.2	-0.6	1.0	0.5	1.3
Total zone transitions, hab. session 2	0.5	0.6	1.8	1.3	1.0	-0.7	0.6	-0.0	-0.4
Total locomotion distance, hab. session 2	0.8	1.1	2.3	1.5	1.4	-1.0	1.0	-0.1	0.3
Locomotion velocity, hab. session 2	0.9	1.2	2.8	1.7	1.3	-1.0	1.1	-0.0	0.4
Novel to familiar place preference ratio	0.2	0.2	0.6	0.1	-0.3	-0.8	0.4	-0.4	0.6
Novelty place preference	0.2	0.2	0.6	-0.2	-0.7	-0.5	0.1	-0.8	0.3
Time in novel zone, NPP test	0.3	0.3	0.8	-0.5	-0.8	-0.3	-0.2	-0.9	0.1
Total zone transitions, NPP test	0.2	0.3	1.1	1.1	0.2	0.2	0.2	0.5	-0.4
Total locomotion distance, NPP test	0.1	0.2	0.6	0.8	0.3	-0.4	0.3	-0.1	0.1
Locomotion velocity, NPP test	0.3	0.4	1.5	1.2	0.3	-0.5	0.5	0.0	0.3
Intraocular pressure	1.2	1.7	2.8	-1.7	-1.3	1.2	-1.7	-1.2	-0.4
Delta distance traveled before/after self-admin	1.9	2.0	6.9	-1.1	0.7	-1.6	-0.8	-2.6	-0.7
Delta ambulatory time before/after self-admin	1.5	1.9	6.3	-0.7	1.0	-1.7	-0.5	-2.5	-0.5
Parametrial fat weight	1.9	4.6	11.2	-3.3	-1.8	1.4	-2.2	-2.3	-1.0
Pavlov. Cond. lever latency	0.2	0.2	0.6	-0.7	0.0	0.6	-0.2	-0.3	0.4
Pavlov. Cond. magazine entry latency	0.1	0.2	0.4	-0.4	0.6	-0.6	-0.1	-0.2	-0.3
Pavlov. Cond. change in total contacts	0.5	0.5	2.3	0.3	-0.2	-0.5	-0.5	-0.5	-1.5
Pavlov. Cond. index score	0.2	0.2	0.9	0.3	0.4	-0.9	0.2	-0.1	-0.3
Pavlov. Cond. latency score	0.3	0.3	1.4	0.5	0.5	-1.2	0.3	-0.2	-0.3
Pavlov. Cond. lever contacts	0.4	0.4	1.1	1.1	0.1	-0.8	0.7	0.6	-0.0
Pavlov. Cond. magazine entry number	0.2	0.2	0.4	0.7	-0.4	0.5	0.3	0.5	0.4
Pavlov. Cond. intertrial magazine entries	1.8	2.1	4.8	-0.8	-2.1	2.2	-0.2	1.6	0.7
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.6	0.2	0.2	-0.8	0.0	-0.2	-0.4
Pavlov. Cond. response bias	0.1	0.1	0.3	-0.1	0.2	0.1	-0.3	0.1	-0.5
Pavlov. Cond. lever latency	0.2	0.3	1.2	0.0	0.5	-0.2	0.3	-0.2	1.1
Pavlov. Cond. magazine entry latency	0.3	0.3	0.6	0.8	0.6	-0.7	0.6	0.4	0.0
Pavlov. Cond. change in total contacts	0.3	0.5	2.0	0.1	-0.7	0.4	-0.7	-0.3	-1.4
Pavlov. Cond. index score	0.2	0.2	0.5	0.6	0.3	-0.4	0.3	0.7	-0.3
Pavlov. Cond. latency score	0.2	0.3	0.5	0.6	0.5	-0.7	0.4	0.5	-0.4
Pavlov. Cond. lever contacts	0.3	0.4	1.8	-0.2	-0.6	0.3	-0.6	-0.0	-1.3
Pavlov. Cond. magazine entry number	0.1	0.1	0.3	0.0	-0.1	-0.0	0.4	0.4	0.5
Pavlov. Cond. intertrial magazine entries	0.3	0.5	1.4	-0.3	-0.6	1.2	0.3	0.8	0.6
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.5	0.6	0.3	-0.3	0.3	0.7	-0.4
Pavlov. Cond. response bias	0.2	0.3	1.0	0.1	-0.6	0.5	-0.4	0.3	-1.0
Time in closed arm before self-admin	0.1	0.2	0.5	0.3	-0.2	0.2	-0.5	-0.3	-0.7
Time in closed arm after self-admin	5.3	5.7	13.4	-2.4	-0.8	0.1	-2.8	-3.7	-2.6
Time in open arm before self-admin	0.4	0.4	1.5	-1.2	-0.4	0.5	-0.3	-0.6	-0.4
Time in open arm after self-admin	0.6	0.7	1.9	0.1	-0.3	0.5	0.9	1.4	1.1
Bone: periosteal estimation	0.4	0.7	2.0	-0.6	-1.4	1.1	-0.4	0.2	-0.9
Bone: periosteal perimeter	0.4	0.7	1.4	0.8	-0.9	1.1	0.2	1.2	-0.4
Bone: post-yield work	0.4	0.5	1.5	-0.3	-0.8	1.2	-0.0	0.9	0.1
Progressive ratio test 1 active lever presses	1.0	1.2	2.5	1.2	1.4	-1.6	1.0	0.1	-0.2
Progressive ratio test 1 breakpoint	1.0	1.2	2.6	1.1	1.5	-1.6	1.0	0.1	-0.2
Progressive ratio test 1 inactive lever presses	1.3	1.9	3.2	1.4	1.5	-1.8	1.6	0.8	0.7
Progressive ratio test 2 active lever presses	1.5	1.8	2.6	1.6	1.5	-1.2	1.6	1.3	0.6
Progressive ratio test 2 breakpoint	1.5	1.7	2.3	1.5	1.5	-1.1	1.5	1.3	0.6
Progressive ratio test 2 inactive lever presses	3.0	4.8	10.3	3.2	1.8	-1.4	2.4	2.6	0.9
Incentive Sensitization - Responses	0.9	1.2	2.3	1.2	0.7	-0.3	1.4	1.5	0.9
Incentive Sensitization - Breakpoint	1.0	1.3	2.8	1.4	0.7	-0.2	1.4	1.7	0.9
Sum of active levers in priming session hrs 5-6	5.0	4.7	7.8	2.3	0.7	-0.9	2.8	2.5	2.8
Progressive ratio	0.2	0.3	0.9	-0.9	-0.3	0.0	-0.7	-0.0	-0.5
Food seeking constrained by brief footshock	0.8	1.0	3.0	0.8	1.1	-1.7	0.8	0.0	0.8
Seeking ratio, punishment vs. effort	0.5	0.8	1.1	1.1	0.9	-0.9	0.9	0.0	1.0
Retroperitoneal fat weight	1.0	4.2	6.8	-2.2	-2.6	1.6	-2.2	-2.0	-1.5
Reaction time number correct	0.4	0.7	2.7	1.6	-0.7	0.5	0.3	0.9	-0.0
Reaction time mean minus median	0.5	1.2	3.9	2.0	0.2	0.0	1.0	1.2	0.8
Reaction time mean minus median AUC	0.5	1.2	4.3	2.1	-0.4	0.5	0.7	1.4	0.3
Reaction time num false alarms	1.1	1.6	4.0	0.2	2.0	-0.8	1.1	0.8	1.6
Reaction time num false alarms AUC	0.8	1.3	4.2	0.1	2.1	-0.8	1.0	0.5	1.2
Reaction time trials correct on left	0.4	0.7	2.7	1.6	-0.7	0.5	0.3	0.9	-0.0
Reaction time trials on left	0.4	0.7	2.8	1.7	-0.6	0.5	0.3	0.9	-0.0
Reaction time mean	0.2	0.3	0.7	-0.9	-0.4	0.6	-0.4	-0.5	0.2
Reaction time mean AUC	0.0	0.1	0.2	-0.3	-0.1	0.4	-0.0	-0.0	0.4
Median of all reaction times	0.8	1.1	3.4	-1.8	-0.6	0.8	-1.0	-1.2	-0.2
Reaction time omissions	0.1	0.2	0.5	0.4	0.4	-0.4	0.7	0.0	0.6
Reaction time false alarm rate	0.9	1.2	4.3	-0.8	2.1	-0.9	0.7	-0.0	1.0
Reaction time premature initiation rate	0.8	1.1	1.9	-1.0	-1.1	0.6	-1.2	-0.7	-1.4
Reaction time premature initiations	0.3	0.6	1.5	0.3	-1.2	0.8	-0.6	0.2	-1.0
Std. dev. reaction times	0.3	0.6	1.7	1.3	0.4	-0.2	0.8	0.7	1.0
Reaction time trials completed	0.4	0.7	2.8	1.7	-0.6	0.5	0.3	0.9	-0.0
Reaction time trials AUC	0.4	0.7	2.2	1.5	-0.8	0.7	0.2	0.8	-0.1
Run reversals in cocaine runway, females	0.1	0.1	0.2	-0.2	0.3	-0.4	0.1	-0.1	0.3
Run reversals in cocaine runway, males	1.0	1.0	3.9	2.0	-0.4	0.8	0.2	1.0	-0.3
Latency to leave start box in cocaine runway	1.5	1.7	3.0	-1.2	-0.7	1.3	-1.5	-1.1	-1.7
Latency to leave start box in cocaine runway, F	0.7	0.8	1.7	-1.1	-0.2	0.3	-0.9	-1.3	-0.9
Latency to leave start box in cocaine runway, M	1.2	1.1	2.4	-0.3	-0.7	1.5	-1.1	0.0	-1.6
Std. dev. time between licks in bursts	0.3	0.3	1.0	0.3	0.8	-0.4	0.5	1.0	0.0
Total sessions with >9 infusions	0.5	0.6	2.2	-0.8	0.5	-1.5	0.6	-0.5	0.4
Short access day 1 total inactive lever presses	1.9	2.5	3.9	1.3	2.0	-1.9	1.5	1.3	1.3
Short access day 10 total inactive lever presses	0.2	0.4	0.9	0.8	0.1	-0.1	0.7	0.8	0.9
Short access day 1 total infusions	0.5	0.7	1.5	-0.2	0.3	-1.2	0.9	-0.4	1.2
Short access day 10 total infusions	0.5	0.7	1.7	-1.1	0.5	-1.3	0.1	-1.0	-0.1
Short access total infusions	0.6	0.8	2.5	-0.7	0.7	-1.6	0.8	-0.6	0.6
Short access day 1 locomotion	1.0	1.2	2.9	-0.0	1.0	-1.7	1.2	-0.2	1.3
Short access day 10 total locomotion	0.2	0.3	1.2	0.7	0.2	-0.2	1.1	0.3	-0.0
Short access total locomotion	0.3	0.4	1.3	0.0	0.5	-1.1	0.9	-0.1	0.1
One hour access (0.3 mA shock)	1.4	1.6	2.6	1.6	1.3	-1.0	1.4	1.6	-0.0
Compulsive drug intake	0.6	0.7	1.6	-1.3	-0.7	0.2	-0.8	-0.9	-0.8
One hour access (shock baseline)	2.0	3.1	5.3	2.1	1.7	-1.1	2.0	2.3	0.8
Social response proportion	0.2	0.3	1.1	-0.1	1.1	-0.3	0.0	-0.1	0.6
Social responses	0.4	0.5	0.9	-0.4	0.9	-0.9	-0.4	-0.9	-0.7
Social time	0.1	0.1	0.4	0.1	0.2	-0.4	0.5	0.1	0.7
Soleus weight	0.1	0.2	0.8	0.1	-0.5	-0.9	0.5	-0.2	-0.3
Bone: stiffness	0.8	1.2	2.2	1.2	0.4	-0.2	1.5	1.4	1.3
Tibialis anterior weight	5.2	17.7	32.6	-4.1	-5.7	4.6	-4.3	-2.0	-3.6
Time to tail flick, vehicle, before self-admin	0.6	0.6	1.7	-0.8	1.3	-0.9	-0.3	0.3	0.5
Time to tail flick, vehicle, after self-admin	2.8	3.6	8.0	-1.9	-1.0	0.8	-2.4	-1.7	-2.8
Time to tail flick, test, before self-admin	1.3	1.4	2.8	-1.2	1.2	-1.4	-0.6	-1.7	-0.6
Time to tail flick, test, after self-admin	0.7	0.7	1.9	0.4	0.9	-1.4	0.1	-1.2	-0.3
Delta time to tail flick, vehicle, before/after SA	1.6	1.5	4.7	-0.5	-1.2	0.8	-1.1	-0.9	-2.2
Delta time to tail flick, test, before/after SA	0.4	0.4	1.2	1.1	0.2	-0.2	0.6	0.5	0.5
Tibia length	0.0	0.1	0.4	0.0	0.3	-0.7	0.1	-0.3	0.1
Ambulatory time before self-admin	0.6	0.9	2.0	0.8	-0.8	1.2	0.5	1.4	0.7
Ambulatory time after self-admin	0.2	0.2	0.6	-0.3	-0.1	-0.5	0.1	-0.8	0.7
Bone: tissue strength	0.3	0.3	0.8	-0.5	0.9	-0.6	-0.2	-0.5	-0.2
Total heroin consumption	7.2	8.5	20.6	4.5	1.4	-1.9	3.7	2.4	2.1
Bone: trabecular number	0.4	0.6	1.1	-0.3	-1.0	0.9	-0.7	-0.7	-0.7
Bone: trabecular spacing	0.8	1.1	3.9	0.3	2.0	-1.3	0.8	0.0	0.4
Bone: trabecular thickness	1.7	2.2	5.7	-0.8	-1.8	2.4	-1.6	-0.4	-0.9
Bone: trabecular tissue density	0.1	0.2	0.9	0.2	0.9	0.1	-0.2	-0.3	-0.4
Water consumed over 24 hours	0.5	0.7	1.6	1.1	1.3	-0.5	0.5	0.7	0.6
Number of responses in last shaping day	0.6	0.7	1.8	0.6	1.2	-1.4	0.3	-0.6	0.0