Kcnh7

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	IC	mRNA stability	Kcnh7	0.1	0.07	3.4e-03	0.02	0.04	0	0.02	4.8e-02	7.4e-03	2.7e-01	4.1e-02
2	IC	gene expression	Kcnh7	0.12	0.07	1.3e-05	0.06	0.1	0.1	0.09	1.7e-03	5.3e-05	7.0e-05	1.3e-04
3	PL	mRNA stability	Kcnh7	0.03	0.02	1.7e-04	0.03	0.03	0.02	0.02	3.6e-04	4.9e-04	3.2e-03	2.5e-03
4	PL	gene expression	Kcnh7	0.07	0.05	2.8e-07	0.06	0.06	0.05	0.05	2.7e-07	6.1e-07	2.3e-06	1.6e-06
5	Brain	gene expression	Kcnh7	0.06	0.04	4.8e-08	0.09	0.08	0.07	0.07	1.5e-08	5.7e-08	3.4e-07	2.3e-07
6	Adipose	gene expression	Kcnh7	0.03	0.03	4.9e-04	0.03	0.03	0.02	0.02	7.6e-04	8.6e-04	5.5e-03	1.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.2	0.4	1.3	-0.3	-0.6	0.3	0.3	0.8	1.1
Area under the delay curve	0.1	0.2	0.5	0.7	0.4	-0.4	-0.5	-0.2	0.2
BMI with tail	0.1	0.3	1.3	-1.1	0.1	0.3	0.3	0.1	-0.3
BMI without tail	0.2	1.3	2.0	-1.4	-1.0	1.2	1.3	1.0	0.9
Body weight	0.4	1.5	5.3	-2.3	-0.8	1.0	1.0	1.0	0.5
Weight adjusted by age	0.5	1.3	3.6	1.9	0.9	-1.0	-1.0	-1.0	-0.6
Bone surface	1.0	1.9	3.3	-1.0	-1.5	1.1	1.1	1.7	1.8
Bone volume	0.6	1.1	2.0	-1.1	-1.0	0.7	0.7	1.3	1.4
Breakpoint value in progressive ratio session	4.3	7.8	9.6	2.4	2.9	-2.9	-3.1	-3.0	-2.4
Number of licking bursts	0.0	0.0	0.1	0.0	-0.2	0.2	0.2	-0.1	0.3
Context. condit. distance diff. score	0.0	0.0	0.1	-0.0	-0.1	-0.1	-0.1	0.2	0.3
Locomotion velocity, session 1	0.4	0.4	0.7	-0.0	-0.7	0.8	0.8	0.6	0.6
Locomotion distance, session 1	0.1	0.1	0.2	0.3	-0.4	0.3	0.2	0.2	0.5
Locomotion velocity, session 2	1.8	2.1	3.5	1.9	1.3	-1.6	-1.6	-1.5	-0.6
Locomotion distance, session 2	0.1	0.2	0.4	-0.5	-0.4	0.3	0.2	0.2	0.6
Locomotion velocity, session 3	0.8	0.9	1.4	1.2	0.8	-1.0	-1.0	-1.0	-0.3
Locomotion distance, session 3	0.3	0.4	0.9	-0.1	-0.6	0.5	0.5	0.7	1.0
Stereotopy head waving bouts, day 3	0.4	0.4	1.7	-1.3	-0.4	0.5	0.4	0.5	0.3
Stereotopy head waving duration, day 3	0.1	0.1	0.3	-0.6	-0.2	0.1	0.0	0.1	0.3
Locomotion velocity, session 7	0.0	0.0	0.1	0.3	-0.0	-0.0	-0.0	-0.0	0.2
Locomotion distance, session 7	0.0	0.0	0.0	-0.0	0.0	-0.0	-0.1	-0.1	0.1
Stereotopy head waving bouts, day 7	0.1	0.1	0.3	-0.5	-0.3	0.3	0.3	0.4	0.1
Stereotopy head waving duration, day 7	0.3	0.3	0.4	-0.5	-0.6	0.5	0.6	0.6	0.6
Locomotion velocity, session 8	0.1	0.1	0.2	0.3	0.0	-0.3	-0.3	-0.2	0.5
Locomotion distance, session 8	0.1	0.1	0.2	0.1	0.2	-0.4	-0.5	-0.3	0.1
Degree of sensitization distance	0.8	0.9	1.3	0.2	1.0	-0.9	-1.0	-1.1	-1.2
Degree of sensitization stereotypy	0.0	0.0	0.1	0.1	0.1	-0.2	-0.0	0.0	-0.2
Conditioned locomotion	0.9	1.0	1.5	1.2	0.8	-1.2	-1.2	-1.0	-0.3
Cocaine response after cond. corrected	5.7	8.6	11.8	2.0	3.1	-3.1	-3.1	-3.4	-2.6
Cocaine response after cond. not corrected	3.6	5.3	8.4	1.2	2.4	-2.5	-2.6	-2.9	-1.8
Cocaine response before conditioning	2.4	2.9	3.6	-1.8	-1.8	1.6	1.6	1.5	1.9
Saline control response	0.2	0.3	0.5	0.3	0.5	-0.4	-0.4	-0.7	-0.6
Bone: connectivity density	0.3	0.5	1.4	0.0	-0.7	0.3	0.3	0.8	1.2
Bone: cortical apparent density	0.2	0.3	0.4	-0.4	-0.5	0.5	0.5	0.6	0.6
Bone: cortical area	4.0	6.6	10.6	-3.3	-2.5	2.4	2.4	2.7	2.0
Bone: cortical porosity	2.2	2.4	2.9	-1.7	-1.5	1.5	1.5	1.7	1.4
Bone: cortical porosity	4.5	5.0	5.6	-2.3	-2.2	2.3	2.3	2.4	1.8
Bone: cortical thickness	3.0	5.1	9.2	-3.0	-2.0	2.2	2.2	2.2	1.4
Bone: cortical thickness	5.5	6.7	10.1	-3.2	-2.5	2.6	2.7	2.6	1.8
Bone: cortical tissue density	0.1	0.2	0.3	-0.3	-0.5	0.4	0.4	0.5	0.6
Condit. Reinf. active minus inactive responses	6.1	6.9	7.5	-2.6	-2.7	2.5	2.6	2.7	2.6
Condit. Reinf. active-inactive response ratio	2.4	2.6	3.5	-1.6	-1.6	1.6	1.6	1.9	1.4
Condit. Reinf. active responses	4.7	6.1	7.5	-2.1	-2.6	2.4	2.4	2.5	2.7
Condit. Reinf. inactive responses	1.3	1.7	2.0	-1.0	-1.4	1.3	1.3	1.3	1.4
Incentive salience index mean	5.5	7.1	7.8	-2.5	-2.8	2.6	2.6	2.8	2.8
Condit. Reinf. lever presses	0.7	1.0	1.2	-0.8	-1.1	1.0	1.0	1.0	1.1
Condit. Reinf. active minus inactive responses	2.6	4.0	4.8	-1.8	-2.1	1.9	1.9	2.1	2.2
Condit. Reinf. active-inactive response ratio	1.4	2.3	2.8	-1.1	-1.7	1.5	1.4	1.6	1.6
Condit. Reinf. active responses	2.7	3.9	5.3	-2.3	-1.9	1.9	1.9	2.0	1.7
Condit. Reinf. inactive responses	0.1	0.2	0.9	-1.0	0.0	0.1	0.2	0.2	-0.2
Condit. Reinf. lever presses	2.9	4.2	6.2	-2.1	-2.1	1.9	1.9	1.8	2.5
Condit. Reinf. lever reinforcers received	1.8	2.5	2.8	-1.6	-1.6	1.6	1.5	1.7	1.5
Conditioned reinforcement - actives	0.6	2.4	4.5	-2.1	-1.3	1.5	1.4	1.7	0.8
Conditioned reinforcement - inactives	0.0	0.1	0.3	-0.5	-0.0	0.3	0.3	0.1	-0.5
Conditioned locomotion	0.1	0.2	0.7	-0.9	0.3	-0.1	-0.2	0.2	-0.4
Patch foraging indifference point 0 sec	0.1	0.2	0.6	-0.8	0.2	0.1	0.2	-0.0	-0.7
Patch foraging indifference point AUC	0.5	1.1	3.4	1.6	-0.8	0.3	0.2	0.3	1.8
Delay disc. indifference point, 0s delay	0.0	0.0	0.1	-0.3	0.0	0.1	0.0	0.1	-0.2
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	-0.3	-0.2	0.3	0.2	0.5	0.5
Delay disc. indifference point, 2s delay	0.3	0.3	0.7	0.3	-0.5	0.6	0.5	0.8	0.6
Delay disc. indifference point, 24s delay	0.3	0.5	1.6	1.2	0.5	-0.7	-0.7	-0.4	-0.2
Delay disc. indifference point, 4s delay	0.6	0.6	1.8	1.3	0.7	-0.7	-0.8	-0.6	-0.1
Delay disc. indifference point, 8s delay	0.2	0.3	0.5	0.6	0.4	-0.6	-0.7	-0.4	0.2
Indifference point function ln k	0.1	0.5	1.5	-1.2	-0.1	0.6	0.6	-0.0	-0.7
Indifference point function log k	0.1	0.5	1.5	-1.2	-0.1	0.6	0.6	-0.0	-0.7
Patch foraging total patch changes 0 sec	0.1	0.2	0.8	-0.4	0.5	-0.2	-0.1	-0.4	-0.9
Patch foraging total patch changes 12 sec	1.3	1.7	3.3	-1.0	-1.5	1.2	1.3	1.0	1.8
Patch foraging total patch changes 18 sec	0.7	1.6	2.7	-0.9	-1.4	1.2	1.2	1.0	1.7
Patch foraging total patch changes 24 sec	0.4	1.2	1.8	-1.1	-1.2	1.0	1.1	0.8	1.4
Patch foraging total patch changes 6 sec	0.1	0.2	0.4	0.7	0.4	-0.4	-0.4	-0.4	-0.3
Patch foraging time to switch 0 sec	0.2	0.8	2.7	-0.9	0.9	-0.5	-0.5	-0.2	-1.6
Patch foraging water rate 0 sec	0.9	3.3	4.1	-1.6	-1.9	1.9	1.9	1.4	2.0
Patch foraging water rate 12 sec	0.8	3.2	3.9	-1.9	-1.9	1.9	2.0	1.1	1.8
Patch foraging water rate 18 sec	2.2	4.9	6.1	-2.0	-2.3	2.4	2.5	2.1	2.0
Patch foraging water rate 24 sec	2.3	3.3	4.2	-1.2	-1.9	1.9	2.1	1.8	1.8
Patch foraging water rate 6 sec	3.5	5.1	7.2	-2.2	-2.3	2.7	2.7	1.7	1.7
Seeking ratio, delayed vs. immediate footshock	0.2	0.3	0.9	-1.0	-0.4	0.2	0.3	0.5	0.2
Distance traveled before self-admin	1.8	4.0	8.6	-2.9	-1.7	2.1	2.1	1.6	0.9
Distance traveled after self-admin	1.6	2.8	4.7	-2.2	-1.5	1.9	1.7	1.4	1.1
Extensor digitorum longus weight	0.2	0.8	1.4	-1.2	-0.8	0.9	0.9	1.0	0.3
Bone: elastic displacement	0.1	0.1	0.6	0.0	0.4	-0.1	-0.1	-0.0	-0.8
Bone: elastic work	0.1	0.1	0.5	-0.3	0.1	0.2	0.2	0.4	-0.7
Bone: endosteal estimation	0.4	0.9	1.9	-0.7	-1.2	0.7	0.7	1.0	1.4
Bone: endosteal perimeter	0.6	1.6	2.3	-0.8	-1.5	1.0	1.0	1.5	1.5
Epididymis fat weight	5.1	25.7	27.9	5.3	5.2	-5.1	-5.1	-4.9	-4.8
Delta time in closed arm before/after self-admin	1.5	1.4	1.9	0.9	1.2	-1.3	-1.4	-1.1	-0.9
Delta time in open arm before/after self-admin	1.6	1.9	2.9	-1.1	-1.3	1.7	1.6	1.5	0.8
Diff in mean of infusions in LGA sessions	7.2	12.9	16.0	3.4	3.8	-3.8	-4.0	-3.3	-3.1
Delay discount exponential model param	0.2	0.3	0.8	-0.9	-0.4	0.5	0.6	0.3	-0.1
Extinction: sum of active levers before priming	0.2	0.4	1.0	-0.5	0.5	-0.4	-0.4	-1.0	-0.6
Active lever presses in extinction session 6	0.4	0.4	2.1	-1.4	0.2	0.1	0.0	-0.1	-0.2
Bone: final force	3.8	6.2	7.8	-2.3	-2.6	2.5	2.5	2.8	2.1
Bone: final moment	3.7	5.9	7.5	-2.3	-2.5	2.5	2.5	2.7	2.0
Food consumed during 24 hour testing period	0.3	0.6	1.5	-1.0	-0.7	0.4	0.4	0.3	1.2
Glucose	0.4	0.6	1.0	-1.0	-0.6	0.8	0.8	0.8	0.5
Heart weight	0.3	0.5	0.7	-0.5	-0.7	0.9	0.7	0.7	0.6
Delay discount hyperbolic model param	0.2	0.3	0.9	-1.0	-0.3	0.4	0.5	0.2	-0.2
Intermittent access intake day 1-15 change	1.0	5.6	7.4	-2.5	-2.4	2.7	2.7	2.0	1.7
Intermittent access intake escalation	0.9	5.0	6.7	-2.3	-2.3	2.5	2.6	2.0	1.6
Intermittent access intake escalation 2	2.1	3.6	5.4	-1.8	-1.9	2.2	2.3	1.7	1.1
Intermitt. access day 1 inactive lever presses	0.1	1.9	2.4	1.2	1.5	-1.3	-1.3	-1.3	-1.5
Intermitt. access day 15 inactive lever presses	0.0	0.1	0.5	0.2	0.3	-0.2	-0.2	-0.3	-0.7
Intermitt. access escalation Index	0.2	0.5	1.1	0.3	-0.6	0.7	0.7	0.8	1.0
Intermittent access day 1 total infusions	0.1	0.3	0.5	-0.0	0.6	-0.7	-0.7	0.2	-0.4
Intermittent access day 15 total infusions	0.8	2.0	2.8	-1.7	-1.3	1.3	1.3	1.6	1.1
Intermittent access terminal intake (last 3 days)	1.6	2.8	4.1	-1.8	-1.6	1.7	1.7	2.0	1.3
Intermittent access total infusions	0.7	0.8	1.7	-1.0	-0.7	0.7	0.6	1.3	0.8
Intermittent access day 1 locomotion	1.3	2.5	3.7	0.7	1.8	-1.7	-1.8	-1.1	-1.9
Intermittent access day 15 total locomotion	0.1	0.3	1.2	-1.1	-0.3	0.4	0.3	0.6	0.1
Intermittent access total locomotion	0.1	0.1	0.4	-0.7	0.2	-0.1	-0.1	0.5	-0.2
Intermittent access standard deviation	0.5	2.4	5.4	-2.3	-1.3	1.6	1.6	1.4	0.6
Left kidney weight	0.2	1.8	2.6	-1.3	-1.5	1.3	1.3	1.0	1.6
Right kidney weight	0.6	4.5	5.4	-2.3	-2.2	2.1	2.1	2.0	1.9
Cocaine induced anxiety	0.2	0.5	1.5	1.2	0.6	-0.5	-0.5	-0.2	-0.5
Post-drug Anxiety	0.3	0.4	0.7	-0.6	-0.6	0.8	0.8	0.5	0.1
Baseline Anxiety	1.4	2.3	6.0	-2.5	-1.4	1.5	1.5	0.9	0.6
Tail length	0.8	4.4	7.1	-1.8	-2.3	1.9	1.9	1.9	2.7
Length with tail	0.6	2.8	4.2	-2.1	-1.7	1.5	1.5	1.5	1.8
Length without tail	0.5	2.8	4.9	-2.2	-1.5	1.6	1.6	1.8	1.2
Times rat made contact with spout	4.4	5.1	7.7	1.8	2.3	-2.5	-2.4	-2.8	-1.6
Lifetime Intake	0.6	0.8	1.8	-1.4	-0.6	0.5	0.5	1.2	0.7
Liver weight, left	0.5	0.8	2.2	-1.5	-0.8	0.9	0.9	0.6	0.4
Liver weight, right	0.2	0.3	0.6	-0.8	0.4	-0.3	-0.3	-0.6	-0.7
Locomotor activity	2.5	3.8	4.6	-2.1	-2.1	1.9	1.9	1.6	2.0
Locomotor testing distance	3.5	8.5	9.4	-3.1	-3.1	3.0	3.0	2.5	2.7
Locomotor testing rearing	2.4	8.9	10.0	-3.2	-3.1	3.1	3.1	2.7	2.6
Locomotion in novel chamber	1.2	1.6	2.8	0.3	1.3	-1.4	-1.4	-1.7	-0.9
Locomotion in novel chamber post-restriction	0.4	1.3	2.1	-1.5	-0.8	1.2	1.2	1.5	0.1
Fecal boli incidents, locomotor time 1	0.1	0.2	0.4	0.5	-0.1	0.5	0.6	0.3	-0.7
Change in fecal boli incidents, locomotor task	0.1	0.1	0.4	-0.7	-0.1	-0.1	-0.1	0.0	0.4
Time >=10cm from walls, locomotor time 1	0.3	0.4	1.0	-1.0	-0.6	0.6	0.7	0.6	0.3
Bouts of movement, locomotor time 1	2.0	2.5	3.1	1.8	1.7	-1.5	-1.5	-1.4	-1.6
Total resting periods, locomotor time 1	1.8	2.1	2.8	1.7	1.5	-1.4	-1.3	-1.2	-1.5
Rest time, locomotor task time 1	1.2	2.0	3.4	1.8	1.5	-1.3	-1.3	-1.3	-1.2
Distance moved, locomotor task time 1	1.2	3.4	5.0	-2.2	-1.7	1.8	1.6	2.0	1.6
Vertical activity count, locomotor time 1	0.1	0.6	0.9	-0.9	-0.7	0.9	0.6	0.9	0.5
Time >=10cm from walls, locomotor time 2	0.0	0.1	0.4	-0.7	-0.2	-0.0	-0.1	-0.3	0.3
Bouts of movement, locomotor time 2	0.5	1.7	3.2	0.7	1.5	-1.2	-1.1	-1.3	-1.8
Total resting periods, locomotor time 2	0.4	1.7	2.9	0.9	1.5	-1.2	-1.1	-1.2	-1.7
Rest time, locomotor task time 2	0.3	0.5	0.9	0.9	0.8	-0.6	-0.6	-0.4	-1.0
Distance moved, locomotor task time 2	0.9	1.2	2.0	-1.4	-1.0	1.1	0.8	1.0	1.0
Vertical activity count, locomotor time 2	0.0	0.0	0.0	0.2	0.1	0.1	-0.2	-0.0	-0.1
Light reinforcement 1	0.1	0.5	0.9	-0.3	-0.8	0.9	0.9	0.3	0.6
Light reinforcement 2	0.4	0.9	2.0	0.8	-1.0	0.9	0.8	0.8	1.4
Bone: marrow area	0.4	1.0	2.1	-0.7	-1.2	0.7	0.7	1.0	1.4
Bone: maximum diameter	1.3	2.7	4.4	-2.1	-1.7	1.3	1.4	1.6	1.6
Bone: maximum force	3.3	6.6	8.1	-2.6	-2.6	2.6	2.6	2.8	2.1
Bone: maximum moment	3.4	6.5	7.9	-2.6	-2.6	2.6	2.6	2.8	2.0
Mean time between licks in bursts	0.0	0.1	0.6	-0.2	-0.3	0.2	0.2	-0.1	0.8
Mean num. licks in bursts	0.7	2.0	2.6	0.9	1.5	-1.6	-1.6	-1.5	-1.2
Cd content in liver	0.1	0.1	0.1	0.2	0.3	-0.3	-0.3	-0.3	-0.4
Co content in liver	0.1	0.1	0.2	-0.5	-0.1	-0.2	-0.2	-0.0	0.4
Cu content in liver	0.6	0.8	1.4	0.4	-1.0	0.9	0.9	0.8	1.2
Fe content in liver	0.1	0.2	0.5	0.6	0.1	0.1	0.1	-0.0	-0.7
K content in liver	0.8	0.8	1.7	0.0	-1.0	0.8	0.8	0.8	1.3
Mg content in liver	1.3	1.5	1.9	-0.6	-1.4	1.3	1.3	1.1	1.4
Mn content in liver	9.8	11.0	14.9	-2.4	-3.6	3.3	3.3	3.3	3.9
Na content in liver	3.9	4.5	5.5	-1.7	-2.3	2.3	2.4	2.0	1.9
Rb content in liver	1.2	1.4	1.7	-1.0	-1.2	1.2	1.1	1.1	1.3
Se content in liver	0.8	0.9	1.0	0.9	0.9	-1.0	-1.0	-0.8	-1.0
Sr content in liver	0.4	0.3	0.4	-0.7	-0.6	0.4	0.5	0.5	0.6
Zn content in liver	0.3	0.4	0.8	-0.1	0.7	-0.6	-0.6	-0.6	-0.9
Bone: minimum diameter	0.8	1.5	2.3	-1.5	-1.2	1.0	1.0	1.5	0.8
Time in familiar zone, hab. session 1	0.3	0.3	0.7	0.8	0.1	-0.4	-0.4	-0.4	0.7
Time in novel zone, hab. session 1	0.5	0.6	2.2	0.1	0.8	-0.5	-0.5	-0.5	-1.5
Total zone transitions, hab. session 1	1.4	1.9	3.1	-1.2	-1.5	1.4	1.2	1.1	1.8
Total locomotion distance, hab. session 1	1.5	2.1	4.2	-0.8	-1.6	1.4	1.3	1.3	2.0
Locomotion velocity, hab. session 1	1.3	1.8	3.4	-0.8	-1.5	1.4	1.2	1.1	1.8
Time in familiar zone, hab. session 2	2.2	2.5	2.9	1.6	1.6	-1.7	-1.7	-1.5	-1.4
Time in novel zone, hab. session 2	1.5	1.6	2.6	-1.6	-1.1	1.3	1.3	1.2	0.9
Total zone transitions, hab. session 2	1.0	1.2	1.9	-1.4	-1.1	1.1	1.0	0.9	1.1
Total locomotion distance, hab. session 2	0.6	0.8	0.9	-0.8	-0.9	1.0	0.9	0.8	0.9
Locomotion velocity, hab. session 2	0.4	0.6	0.8	-0.6	-0.8	0.9	0.8	0.7	0.9
Novel to familiar place preference ratio	0.6	0.8	1.4	-0.0	1.0	-0.9	-0.9	-0.8	-1.2
Novelty place preference	0.7	0.9	1.5	0.0	1.1	-1.0	-1.0	-0.9	-1.2
Time in novel zone, NPP test	0.8	0.9	1.9	-0.1	1.1	-1.0	-1.0	-0.8	-1.4
Total zone transitions, NPP test	0.1	0.1	0.4	-0.1	-0.4	0.3	0.2	0.2	0.7
Total locomotion distance, NPP test	0.7	1.0	2.1	-0.5	-1.2	1.0	0.9	0.8	1.4
Locomotion velocity, NPP test	0.8	1.2	2.4	-0.5	-1.2	1.1	1.0	0.9	1.6
Intraocular pressure	1.1	1.8	2.5	-1.6	-1.4	1.4	1.5	1.1	1.1
Delta distance traveled before/after self-admin	0.5	0.5	1.4	1.2	0.7	-0.6	-0.8	-0.7	-0.3
Delta ambulatory time before/after self-admin	0.1	0.2	0.3	0.0	-0.5	0.5	0.4	0.3	0.5
Parametrial fat weight	2.8	6.5	7.3	2.6	2.6	-2.4	-2.4	-2.5	-2.7
Pavlov. Cond. lever latency	0.3	0.4	1.0	1.0	0.5	-0.5	-0.6	-0.4	-0.1
Pavlov. Cond. magazine entry latency	0.1	0.1	0.4	-0.6	-0.1	0.1	0.2	0.0	-0.2
Pavlov. Cond. change in total contacts	1.2	1.3	1.4	-1.1	-1.2	1.1	1.2	1.1	0.9
Pavlov. Cond. index score	0.4	0.5	1.3	-1.1	-0.7	0.7	0.8	0.6	0.3
Pavlov. Cond. latency score	0.4	0.5	1.3	-1.1	-0.6	0.6	0.6	0.5	0.2
Pavlov. Cond. lever contacts	0.7	0.8	1.7	-1.3	-0.9	0.9	0.9	0.7	0.5
Pavlov. Cond. magazine entry number	0.3	0.4	0.5	0.7	0.6	-0.6	-0.7	-0.6	-0.3
Pavlov. Cond. intertrial magazine entries	0.9	1.1	2.1	-1.1	-1.1	0.8	0.8	0.8	1.5
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	1.4	-1.2	-0.7	0.7	0.8	0.7	0.3
Pavlov. Cond. response bias	0.3	0.4	0.7	-0.8	-0.7	0.7	0.8	0.6	0.3
Pavlov. Cond. lever latency	1.5	2.1	3.7	1.9	1.4	-1.2	-1.1	-0.8	-1.9
Pavlov. Cond. magazine entry latency	1.0	1.3	2.6	0.1	1.1	-1.4	-1.4	-1.6	-0.5
Pavlov. Cond. change in total contacts	0.3	0.8	2.2	-0.7	-1.0	0.7	0.7	0.4	1.5
Pavlov. Cond. index score	0.2	0.3	0.6	-0.7	0.1	-0.4	-0.4	-0.8	0.6
Pavlov. Cond. latency score	0.2	0.4	1.2	-0.4	0.4	-0.6	-0.7	-1.1	0.4
Pavlov. Cond. lever contacts	1.3	1.9	3.5	-1.8	-1.3	1.1	1.1	0.8	1.9
Pavlov. Cond. magazine entry number	1.2	1.5	2.6	-0.5	-1.2	1.5	1.5	1.6	0.5
Pavlov. Cond. intertrial magazine entries	1.3	2.8	3.9	-1.5	-1.7	1.9	1.9	2.0	1.0
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.8	-0.5	0.2	-0.5	-0.5	-0.9	0.5
Pavlov. Cond. response bias	0.6	0.8	2.3	-1.5	-0.7	0.5	0.5	0.3	1.2
Time in closed arm before self-admin	0.0	0.0	0.0	0.2	-0.0	-0.1	-0.0	0.1	0.0
Time in closed arm after self-admin	0.2	0.3	0.4	0.4	0.6	-0.6	-0.6	-0.4	-0.4
Time in open arm before self-admin	3.4	4.2	5.1	1.9	2.0	-2.3	-2.1	-2.1	-1.7
Time in open arm after self-admin	0.1	0.1	0.4	-0.0	0.3	-0.3	-0.3	-0.3	-0.6
Bone: periosteal estimation	2.1	4.9	6.6	-2.6	-2.3	2.0	2.0	2.3	2.0
Bone: periosteal perimeter	1.8	3.6	4.5	-2.1	-2.0	1.8	1.8	2.1	1.6
Bone: post-yield work	0.6	1.0	1.3	-0.9	-1.1	1.1	1.1	1.0	0.8
Progressive ratio test 1 active lever presses	1.1	1.9	4.5	-2.1	-1.0	1.2	1.1	1.6	0.8
Progressive ratio test 1 breakpoint	1.1	1.8	4.3	-2.1	-1.0	1.2	1.1	1.5	0.8
Progressive ratio test 1 inactive lever presses	0.0	0.1	0.5	-0.7	0.0	0.1	0.1	0.3	-0.2
Progressive ratio test 2 active lever presses	0.8	1.1	2.1	-0.8	-1.0	0.8	0.8	1.5	1.1
Progressive ratio test 2 breakpoint	0.9	1.1	2.1	-0.9	-1.0	0.9	0.8	1.4	1.1
Progressive ratio test 2 inactive lever presses	0.3	0.9	1.7	-0.6	-1.0	1.0	1.0	1.3	0.9
Incentive Sensitization - Responses	0.2	0.7	1.3	-0.1	-0.8	0.6	0.6	1.1	1.1
Incentive Sensitization - Breakpoint	0.3	0.7	1.3	-0.0	-0.8	0.6	0.6	1.1	1.1
Sum of active levers in priming session hrs 5-6	3.4	3.2	6.0	1.2	1.9	-1.5	-1.7	-2.5	-1.7
Progressive ratio	0.4	1.3	4.4	-2.1	-0.6	0.8	0.9	1.2	0.1
Food seeking constrained by brief footshock	0.3	0.4	0.7	-0.2	-0.5	0.8	0.7	0.4	0.9
Seeking ratio, punishment vs. effort	0.2	0.5	1.5	1.2	0.4	-0.4	-0.5	-1.0	0.1
Retroperitoneal fat weight	3.9	17.4	18.2	4.3	4.2	-4.2	-4.2	-3.9	-4.1
Reaction time number correct	0.1	0.2	0.9	-0.9	-0.2	0.4	0.4	0.2	0.2
Reaction time mean minus median	0.3	2.2	5.3	2.3	1.1	-1.6	-1.6	-1.2	-0.1
Reaction time mean minus median AUC	0.6	3.8	8.3	2.9	1.6	-2.1	-2.1	-1.7	-0.3
Reaction time num false alarms	1.5	2.5	4.1	-1.1	-1.8	1.5	1.5	1.4	2.0
Reaction time num false alarms AUC	1.4	3.1	5.0	-1.4	-2.0	1.6	1.6	1.7	2.2
Reaction time trials correct on left	0.1	0.2	0.9	-0.9	-0.2	0.4	0.4	0.2	0.2
Reaction time trials on left	0.1	0.2	0.8	-0.9	-0.3	0.4	0.4	0.2	0.3
Reaction time mean	1.3	2.8	9.4	3.1	1.2	-1.6	-1.5	-1.1	-0.2
Reaction time mean AUC	1.5	3.6	10.4	3.2	1.6	-1.9	-1.8	-1.3	-0.6
Median of all reaction times	1.2	1.9	7.3	2.7	0.9	-1.2	-1.1	-0.7	-0.1
Reaction time omissions	0.8	1.3	3.3	1.8	1.0	-1.2	-1.1	-1.0	-0.1
Reaction time false alarm rate	1.2	1.6	3.2	-0.6	-1.5	1.1	1.1	1.2	1.8
Reaction time premature initiation rate	0.3	0.5	0.9	1.0	0.5	-0.6	-0.5	-0.8	-0.6
Reaction time premature initiations	0.0	0.1	0.3	0.4	0.3	-0.3	-0.2	-0.5	-0.3
Std. dev. reaction times	0.7	2.4	6.6	2.6	1.1	-1.6	-1.6	-1.1	-0.0
Reaction time trials completed	0.1	0.2	0.8	-0.9	-0.3	0.4	0.4	0.2	0.3
Reaction time trials AUC	0.2	0.6	1.4	-1.2	-0.6	0.8	0.8	0.6	0.6
Run reversals in cocaine runway, females	0.2	0.2	0.7	0.1	0.3	0.1	0.1	-0.6	-0.8
Run reversals in cocaine runway, males	0.3	0.4	1.3	1.1	0.3	-0.6	-0.6	-0.1	0.3
Latency to leave start box in cocaine runway	0.6	0.9	1.6	1.1	0.7	-0.9	-1.0	-1.3	-0.5
Latency to leave start box in cocaine runway, F	0.5	0.6	1.4	0.6	0.6	-0.8	-0.8	-1.2	-0.4
Latency to leave start box in cocaine runway, M	0.8	0.8	1.8	1.3	0.7	-0.9	-0.9	-0.8	-0.6
Std. dev. time between licks in bursts	1.4	2.6	3.0	-1.5	-1.6	1.6	1.7	1.4	1.7
Total sessions with >9 infusions	0.3	0.4	2.2	-1.5	-0.1	0.1	0.0	0.4	-0.1
Short access day 1 total inactive lever presses	0.5	1.0	2.0	0.5	1.0	-1.1	-1.1	-1.4	-0.8
Short access day 10 total inactive lever presses	0.2	1.0	1.7	1.2	0.9	-0.8	-0.7	-1.3	-1.0
Short access day 1 total infusions	0.3	0.6	1.3	-1.2	-0.5	0.5	0.5	0.9	0.9
Short access day 10 total infusions	0.6	1.0	3.8	-1.9	-0.5	0.5	0.5	1.0	0.4
Short access total infusions	0.2	0.3	1.5	-1.2	-0.0	-0.0	-0.1	0.6	0.2
Short access day 1 locomotion	0.2	0.3	0.4	-0.7	0.6	-0.5	-0.5	-0.3	-0.5
Short access day 10 total locomotion	0.1	0.2	0.4	-0.2	0.7	-0.4	-0.5	0.1	-0.6
Short access total locomotion	0.3	0.4	0.5	-0.7	0.7	-0.6	-0.7	-0.1	-0.7
One hour access (0.3 mA shock)	1.4	1.6	2.7	-1.4	-1.2	1.1	1.0	1.7	1.2
Compulsive drug intake	6.7	9.9	11.2	2.7	3.3	-3.2	-3.3	-3.0	-3.4
One hour access (shock baseline)	2.8	7.3	9.0	-2.5	-2.7	2.6	2.6	3.0	2.8
Social response proportion	0.8	1.0	2.4	1.5	0.9	-1.0	-1.0	-0.7	0.2
Social responses	1.9	2.5	5.3	-1.0	-1.6	1.5	1.5	1.2	2.3
Social time	0.5	0.9	2.0	1.4	0.6	-0.9	-0.9	-1.0	-0.1
Soleus weight	0.0	0.1	0.4	-0.4	0.1	0.1	0.1	-0.1	-0.6
Bone: stiffness	4.5	8.1	8.9	-2.9	-2.9	2.8	2.8	3.0	2.7
Tibialis anterior weight	0.2	0.8	1.6	0.3	1.0	-1.0	-0.9	-0.7	-1.3
Time to tail flick, vehicle, before self-admin	2.5	3.1	5.3	1.1	1.7	-1.5	-1.8	-2.3	-1.9
Time to tail flick, vehicle, after self-admin	1.9	3.9	5.4	2.3	2.1	-2.0	-2.0	-1.2	-2.0
Time to tail flick, test, before self-admin	0.1	0.2	0.9	1.0	0.0	0.1	0.0	-0.0	0.2
Time to tail flick, test, after self-admin	0.2	0.2	0.8	0.2	0.4	-0.3	-0.3	-0.3	-0.9
Delta time to tail flick, vehicle, before/after SA	0.9	1.0	2.7	-0.0	-0.8	0.8	0.9	1.6	1.0
Delta time to tail flick, test, before/after SA	0.6	0.7	1.0	0.5	0.8	-1.0	-1.0	-0.8	-0.9
Tibia length	6.5	18.2	22.1	-4.5	-4.3	3.9	3.9	4.2	4.7
Ambulatory time before self-admin	1.2	3.5	7.8	-2.8	-1.6	1.9	1.9	1.5	1.0
Ambulatory time after self-admin	0.9	1.5	2.7	-1.6	-1.1	1.4	1.3	0.8	0.8
Bone: tissue strength	0.6	0.6	0.9	-0.4	-0.8	0.8	0.8	0.8	1.0
Total heroin consumption	1.9	2.3	3.9	0.3	1.8	-1.3	-1.5	-1.6	-2.0
Bone: trabecular number	0.1	0.3	0.6	0.0	-0.5	0.3	0.3	0.7	0.8
Bone: trabecular spacing	0.3	0.4	0.9	0.0	0.7	-0.6	-0.5	-0.9	-0.6
Bone: trabecular thickness	1.1	1.5	2.5	-0.9	-1.3	1.1	1.1	1.6	1.3
Bone: trabecular tissue density	0.4	0.7	1.1	-0.8	-0.9	0.8	0.8	0.7	1.1
Water consumed over 24 hours	0.3	0.6	3.0	-1.7	-0.4	0.5	0.5	0.2	0.3
Number of responses in last shaping day	1.2	1.5	2.1	-1.1	-1.1	1.2	1.1	1.4	1.4