Hub : Genes

Kcnh3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL alternative TSS XM_039078511.1 0.03 0.03 2.0e-03 0.01 0.02 0.02 0.02 7.0e-03 1.8e-03 5.2e-03 6.1e-03
2 PL alternative TSS NM_017108.1 0.03 0.02 2.4e-04 0.03 0.03 0.03 0.03 4.0e-04 2.9e-04 4.9e-04 5.4e-04
3 BLA gene expression Kcnh3 0.29 0.15 0.0e+00 0.29 0.31 0.3 0.3 1.1e-15 4.3e-17 1.0e-16 1.0e-16
4 Brain intron excision ratio chr7_130367391_130367495 0.03 0.03 8.3e-04 0.03 0.03 0.03 0.03 1.1e-03 3.9e-04 7.6e-04 9.0e-04
5 PL alternative TSS NM_017108.1 0.05 0.04 2.2e-06 0.05 0.05 0.05 0.05 3.4e-06 2.2e-06 4.6e-06 3.5e-06
6 NAcc gene expression Kcnh3 0.04 0.04 5.1e-05 0.03 0.04 0.04 0.03 7.9e-05 3.9e-05 3.1e-05 8.1e-05
7 Brain gene expression Kcnh3 0.56 0.12 0.0e+00 0.67 0.69 0.69 0.69 6.0e-84 1.3e-87 5.8e-87 1.5e-87
8 BLA mRNA stability Kcnh3 0.06 0.06 4.9e-03 0.04 0.03 0.02 0.04 3.3e-03 6.7e-03 2.7e-02 4.7e-03
9 PL gene expression Kcnh3 0.15 0.08 0.0e+00 0.17 0.16 0.16 0.17 1.4e-18 2.0e-17 9.1e-18 2.5e-18
10 PL isoform ratio NM_017108.1 0.02 0.02 3.1e-03 0.03 0.02 0.02 0.02 4.9e-04 2.3e-03 1.5e-03 1.2e-03
11 PL mRNA stability Kcnh3 0.18 0.15 6.4e-11 0.09 0.1 0.09 0.09 5.8e-10 1.3e-10 2.5e-10 2.8e-10
12 OFC mRNA stability Kcnh3 0.21 0.18 2.1e-03 0.07 0.13 0.06 0.07 9.8e-03 6.3e-04 1.7e-02 1.0e-02
13 NAcc mRNA stability Kcnh3 0.08 0.05 8.3e-05 0.03 0.04 0.02 0.03 3.2e-04 1.9e-05 8.2e-04 6.3e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density10.317.218.84.3-4.3-4.3-4.2-4.34.1-4.24.24.34.3-4.1-4.0-3.3
Area under the delay curve0.90.91.71.0-1.0-1.0-1.0-1.01.3-1.00.91.00.9-0.8-0.8-0.4
BMI with tail3.912.814.93.9-3.8-3.8-3.8-3.83.8-3.73.73.53.6-3.4-3.3-2.1
BMI without tail0.10.21.2-0.10.10.10.20.20.30.2-0.2-0.3-0.20.50.51.1
Body weight5.723.929.75.1-5.1-5.1-5.0-5.05.4-5.05.04.84.9-4.7-4.6-3.4
Weight adjusted by age1.92.12.51.4-1.4-1.4-1.4-1.41.5-1.41.41.51.5-1.5-1.6-1.4
Bone surface11.921.023.44.8-4.8-4.7-4.7-4.74.6-4.74.64.84.7-4.5-4.4-3.3
Bone volume9.015.317.24.1-4.1-4.1-4.0-4.14.1-4.03.94.14.1-3.7-3.6-2.5
Breakpoint value in progressive ratio session0.20.30.30.5-0.5-0.5-0.5-0.50.5-0.50.60.50.4-0.6-0.5-0.6
Number of licking bursts0.70.82.2-0.90.91.00.90.9-1.50.9-0.9-0.8-0.90.70.50.3
Context. condit. distance diff. score0.20.20.30.5-0.5-0.5-0.5-0.50.6-0.50.60.40.4-0.5-0.5-0.5
Locomotion velocity, session 11.01.11.9-1.31.21.21.21.2-1.41.1-1.0-1.0-1.00.70.6-0.3
Locomotion distance, session 12.43.13.7-1.91.91.91.81.9-1.81.8-1.7-1.8-1.81.61.60.8
Locomotion velocity, session 20.20.20.4-0.50.50.50.50.5-0.70.5-0.5-0.3-0.40.40.40.2
Locomotion distance, session 22.02.83.8-1.91.81.81.81.8-1.91.7-1.7-1.6-1.61.51.50.6
Locomotion velocity, session 33.84.55.8-2.32.32.32.32.2-2.42.2-2.2-2.0-2.01.91.81.2
Locomotion distance, session 34.85.26.0-2.32.32.32.42.4-2.02.4-2.5-2.1-2.22.42.32.0
Stereotopy head waving bouts, day 31.11.32.01.0-1.1-1.0-1.0-1.10.8-1.11.11.21.3-1.3-1.4-1.4
Stereotopy head waving duration, day 30.60.71.70.7-0.7-0.7-0.7-0.80.4-0.80.90.80.8-1.0-1.1-1.3
Locomotion velocity, session 70.30.40.6-0.80.70.80.70.7-0.80.6-0.6-0.4-0.40.20.1-0.6
Locomotion distance, session 71.82.33.0-1.71.71.71.71.7-1.61.6-1.6-1.4-1.41.31.10.4
Stereotopy head waving bouts, day 70.80.91.31.0-1.0-0.9-0.9-0.90.9-0.90.91.11.1-0.9-1.0-0.5
Stereotopy head waving duration, day 71.11.31.71.2-1.2-1.2-1.2-1.21.2-1.21.11.31.2-1.1-1.2-0.6
Locomotion velocity, session 80.10.10.4-0.10.00.00.00.0-0.5-0.10.1-0.0-0.0-0.2-0.3-0.6
Locomotion distance, session 81.01.41.8-1.41.31.31.31.3-1.21.2-1.2-1.3-1.31.11.10.4
Degree of sensitization distance0.40.40.90.6-0.6-0.6-0.6-0.60.5-0.70.70.60.6-0.8-0.8-1.0
Degree of sensitization stereotypy0.10.20.40.5-0.4-0.4-0.4-0.40.6-0.30.30.50.4-0.2-0.20.5
Conditioned locomotion0.10.10.10.2-0.2-0.2-0.2-0.2-0.4-0.20.10.30.3-0.3-0.3-0.4
Cocaine response after cond. corrected0.00.00.1-0.00.00.00.00.00.40.0-0.0-0.0-0.10.10.10.0
Cocaine response after cond. not corrected0.50.50.7-0.70.70.70.70.7-0.40.7-0.7-0.7-0.80.80.80.7
Cocaine response before conditioning3.34.04.7-2.02.02.02.02.0-2.22.0-2.0-1.9-2.02.01.91.6
Saline control response0.20.20.70.3-0.4-0.4-0.4-0.4-0.3-0.40.40.50.4-0.6-0.6-0.8
Bone: connectivity density7.511.713.43.5-3.5-3.4-3.5-3.53.0-3.53.43.73.5-3.5-3.5-3.0
Bone: cortical apparent density0.20.30.4-0.60.60.60.60.6-0.20.6-0.6-0.5-0.70.60.60.4
Bone: cortical area8.913.415.83.8-3.8-3.7-3.7-3.83.5-3.73.74.03.8-3.6-3.7-2.6
Bone: cortical porosity0.50.61.0-0.70.70.70.70.7-0.50.7-0.7-0.9-0.70.91.01.0
Bone: cortical porosity0.91.01.4-0.90.90.90.90.9-0.71.0-1.0-1.1-0.91.11.21.2
Bone: cortical thickness2.94.86.12.3-2.3-2.2-2.2-2.22.0-2.22.22.52.3-2.2-2.3-1.5
Bone: cortical thickness0.10.10.40.1-0.2-0.1-0.1-0.2-0.2-0.20.20.40.3-0.4-0.5-0.6
Bone: cortical tissue density0.30.40.6-0.70.70.70.70.7-0.30.7-0.7-0.6-0.70.70.70.4
Condit. Reinf. active minus inactive responses0.00.00.1-0.30.30.30.20.2-0.10.2-0.2-0.2-0.20.10.1-0.1
Condit. Reinf. active-inactive response ratio0.30.30.70.5-0.5-0.5-0.5-0.50.6-0.50.50.60.5-0.6-0.6-0.8
Condit. Reinf. active responses0.60.70.8-0.90.90.90.90.9-0.90.9-0.9-0.9-0.80.70.70.3
Condit. Reinf. inactive responses2.83.33.7-1.91.91.91.91.9-1.91.9-1.9-1.9-1.91.81.71.3
Incentive salience index mean0.00.00.00.1-0.1-0.1-0.1-0.10.2-0.10.10.10.1-0.1-0.2-0.2
Condit. Reinf. lever presses0.10.10.50.4-0.4-0.4-0.4-0.40.7-0.30.20.30.4-0.2-0.10.2
Condit. Reinf. active minus inactive responses0.10.10.90.1-0.0-0.1-0.0-0.0-0.10.1-0.1-0.1-0.00.40.41.0
Condit. Reinf. active-inactive response ratio0.50.52.8-0.30.40.40.40.4-0.50.5-0.6-0.5-0.60.91.01.7
Condit. Reinf. active responses0.20.30.9-0.30.40.40.40.4-0.40.4-0.5-0.5-0.40.60.70.9
Condit. Reinf. inactive responses0.50.60.8-0.90.90.90.90.9-0.60.8-0.8-0.9-0.80.70.70.4
Condit. Reinf. lever presses0.00.00.10.0-0.0-0.0-0.0-0.0-0.4-0.0-0.0-0.00.00.00.00.0
Condit. Reinf. lever reinforcers received0.50.71.2-0.70.80.70.80.8-0.90.8-0.8-0.8-0.70.91.01.1
Conditioned reinforcement - actives1.71.71.9-1.31.31.31.31.3-1.21.3-1.4-1.2-1.21.41.31.4
Conditioned reinforcement - inactives2.22.52.9-1.61.61.71.71.6-1.71.7-1.6-1.4-1.31.61.41.3
Conditioned locomotion0.40.50.7-0.70.70.70.70.7-0.80.7-0.7-0.6-0.50.70.70.8
Patch foraging indifference point 0 sec2.43.96.6-2.32.22.22.22.1-2.62.0-1.9-1.9-1.91.51.30.3
Patch foraging indifference point AUC0.40.41.0-0.50.50.60.60.6-1.00.6-0.7-0.3-0.30.70.61.0
Delay disc. indifference point, 0s delay1.21.31.61.3-1.2-1.2-1.2-1.21.3-1.21.11.31.2-1.0-1.0-0.3
Delay disc. indifference point, 16s delay0.80.81.21.0-1.0-0.9-0.9-0.91.1-0.90.90.90.9-0.8-0.8-0.3
Delay disc. indifference point, 2s delay1.51.72.91.4-1.4-1.4-1.4-1.31.7-1.31.31.21.2-1.2-1.1-0.8
Delay disc. indifference point, 24s delay1.31.21.61.1-1.1-1.1-1.1-1.11.0-1.11.11.21.3-1.1-1.1-0.9
Delay disc. indifference point, 4s delay0.30.30.90.6-0.6-0.7-0.6-0.61.0-0.60.50.40.4-0.4-0.2-0.1
Delay disc. indifference point, 8s delay2.32.42.91.6-1.6-1.6-1.6-1.61.7-1.61.51.71.6-1.5-1.5-1.1
Indifference point function ln k4.05.67.72.5-2.5-2.5-2.5-2.52.8-2.52.32.32.3-2.2-2.1-1.5
Indifference point function log k4.05.67.72.5-2.5-2.5-2.5-2.52.8-2.52.32.32.3-2.2-2.1-1.5
Patch foraging total patch changes 0 sec2.33.76.5-2.22.12.22.12.1-2.52.0-1.9-1.9-1.91.51.30.4
Patch foraging total patch changes 12 sec2.43.14.7-2.02.02.02.01.9-2.21.9-1.9-1.6-1.61.41.20.7
Patch foraging total patch changes 18 sec4.55.79.8-2.62.52.62.62.5-3.12.5-2.6-2.2-2.22.11.91.2
Patch foraging total patch changes 24 sec2.42.94.7-1.91.81.91.91.8-2.21.8-1.8-1.5-1.61.41.20.8
Patch foraging total patch changes 6 sec2.84.16.6-2.32.22.32.32.2-2.62.1-2.2-1.8-1.81.61.40.6
Patch foraging time to switch 0 sec2.23.34.3-2.01.91.91.91.9-1.71.9-1.9-2.1-2.01.71.70.8
Patch foraging water rate 0 sec2.64.25.22.2-2.2-2.1-2.1-2.12.1-2.12.12.32.2-1.9-1.9-0.9
Patch foraging water rate 12 sec3.75.66.42.4-2.4-2.4-2.4-2.41.9-2.42.52.52.5-2.4-2.4-1.9
Patch foraging water rate 18 sec0.30.40.80.6-0.6-0.6-0.6-0.60.9-0.60.80.50.5-0.5-0.5-0.3
Patch foraging water rate 24 sec3.14.35.32.3-2.3-2.3-2.2-2.22.1-2.22.22.12.0-1.9-1.8-1.0
Patch foraging water rate 6 sec3.65.36.62.6-2.5-2.5-2.4-2.52.5-2.42.42.42.4-2.0-1.9-0.9
Seeking ratio, delayed vs. immediate footshock0.20.30.40.6-0.6-0.6-0.6-0.6-0.0-0.50.50.60.6-0.4-0.4-0.0
Distance traveled before self-admin1.11.11.6-1.31.21.21.21.2-0.71.1-1.1-1.2-1.10.90.80.1
Distance traveled after self-admin0.10.20.3-0.50.50.50.50.5-0.20.5-0.4-0.5-0.30.30.2-0.1
Extensor digitorum longus weight3.513.818.94.1-4.0-4.0-4.0-3.94.3-3.93.83.83.7-3.3-3.2-1.7
Bone: elastic displacement3.94.45.7-2.42.32.32.22.2-2.42.1-2.0-2.3-2.41.81.70.6
Bone: elastic work0.10.10.50.1-0.1-0.2-0.2-0.20.6-0.20.3-0.0-0.0-0.3-0.2-0.7
Bone: endosteal estimation7.816.918.74.3-4.3-4.3-4.3-4.34.1-4.24.24.24.3-4.0-3.8-3.0
Bone: endosteal perimeter6.313.115.23.9-3.9-3.8-3.8-3.83.5-3.73.73.93.7-3.4-3.4-2.1
Epididymis fat weight0.20.41.00.5-0.6-0.6-0.6-0.60.4-0.60.60.40.6-0.7-0.7-1.0
Delta time in closed arm before/after self-admin0.30.20.30.5-0.5-0.5-0.5-0.50.2-0.50.40.60.5-0.5-0.6-0.5
Delta time in open arm before/after self-admin4.34.15.2-2.12.12.12.12.1-2.32.1-2.0-2.1-2.01.91.91.4
Diff in mean of infusions in LGA sessions1.61.82.21.4-1.4-1.4-1.4-1.41.5-1.41.41.31.2-1.3-1.3-1.0
Delay discount exponential model param0.80.81.7-1.01.01.01.01.0-1.30.9-0.9-0.9-0.90.80.70.4
Extinction: sum of active levers before priming0.60.61.10.8-0.7-0.8-0.8-0.81.1-0.80.80.60.6-0.7-0.7-0.6
Active lever presses in extinction session 60.40.40.50.6-0.6-0.6-0.7-0.70.5-0.70.70.70.7-0.7-0.7-0.7
Bone: final force10.116.318.64.3-4.3-4.3-4.2-4.24.3-4.24.14.14.1-3.8-3.7-2.6
Bone: final moment10.917.620.34.5-4.5-4.5-4.4-4.44.5-4.34.34.34.2-3.9-3.7-2.7
Food consumed during 24 hour testing period1.72.02.61.5-1.5-1.5-1.5-1.51.3-1.51.41.61.6-1.4-1.4-0.8
Glucose0.10.10.6-0.0-0.00.0-0.0-0.0-0.6-0.10.10.10.1-0.4-0.5-0.8
Heart weight0.10.10.20.3-0.3-0.3-0.3-0.30.5-0.30.30.20.3-0.3-0.3-0.3
Delay discount hyperbolic model param0.80.91.8-1.01.01.01.01.0-1.30.9-0.9-0.9-0.80.80.70.5
Intermittent access intake day 1-15 change1.81.73.2-1.21.21.21.31.2-1.01.3-1.4-1.2-1.11.51.51.8
Intermittent access intake escalation1.31.33.1-0.91.01.01.01.0-0.61.1-1.2-1.0-0.91.41.41.7
Intermittent access intake escalation 22.02.04.0-1.21.21.31.31.3-0.91.4-1.5-1.3-1.21.61.62.0
Intermitt. access day 1 inactive lever presses2.32.43.6-1.51.51.41.51.5-1.01.5-1.4-1.9-1.91.71.81.4
Intermitt. access day 15 inactive lever presses1.21.31.9-1.01.11.01.11.1-0.81.1-1.1-1.3-1.11.31.41.3
Intermitt. access escalation Index0.30.30.5-0.60.50.50.50.5-0.60.4-0.4-0.7-0.70.20.2-0.4
Intermittent access day 1 total infusions1.11.31.6-1.21.21.31.21.2-1.11.2-1.2-1.1-1.21.11.00.8
Intermittent access day 15 total infusions2.93.33.8-1.81.81.91.91.9-1.61.9-2.0-1.7-1.71.91.81.7
Intermittent access terminal intake (last 3 days)3.23.44.1-1.91.91.91.91.9-1.61.9-2.0-1.7-1.71.91.91.8
Intermittent access total infusions2.93.23.7-1.81.81.91.91.8-1.51.9-1.9-1.7-1.71.91.81.7
Intermittent access day 1 locomotion0.80.91.1-1.11.01.01.01.0-1.10.9-0.9-1.0-1.00.80.70.2
Intermittent access day 15 total locomotion1.71.92.1-1.41.41.41.41.4-1.41.4-1.4-1.3-1.21.41.31.2
Intermittent access total locomotion3.43.84.8-2.12.12.12.12.1-2.22.0-2.0-1.9-1.91.81.71.2
Intermittent access standard deviation0.70.71.9-0.60.70.70.70.7-0.40.8-0.8-0.8-0.81.01.11.4
Left kidney weight0.51.35.01.2-1.1-1.1-1.1-1.12.2-1.01.01.01.1-0.8-0.7-0.1
Right kidney weight2.67.211.42.8-2.8-2.7-2.7-2.73.4-2.72.62.72.9-2.5-2.5-1.8
Cocaine induced anxiety1.01.22.01.1-1.1-1.1-1.1-1.11.4-1.11.11.11.1-1.0-1.0-0.7
Post-drug Anxiety5.05.67.72.5-2.5-2.4-2.4-2.42.8-2.42.42.32.4-2.2-2.2-1.6
Baseline Anxiety0.91.01.11.0-1.0-1.0-1.0-1.01.0-1.01.01.01.0-1.0-0.9-0.8
Tail length0.10.30.6-0.60.60.60.60.60.00.6-0.6-0.6-0.50.70.60.8
Length with tail1.97.010.52.7-2.7-2.7-2.7-2.73.2-2.72.62.62.8-2.5-2.5-1.9
Length without tail7.416.116.94.1-4.1-4.1-4.1-4.14.0-4.14.14.04.1-4.0-4.0-3.3
Times rat made contact with spout0.10.20.4-0.30.30.40.40.4-0.30.4-0.4-0.5-0.50.40.40.7
Lifetime Intake2.93.33.9-1.91.91.91.91.9-1.71.9-2.0-1.6-1.61.81.71.6
Liver weight, left1.72.83.11.7-1.7-1.7-1.7-1.71.5-1.71.71.71.7-1.7-1.6-1.3
Liver weight, right1.42.43.41.6-1.6-1.6-1.6-1.61.8-1.61.51.51.4-1.5-1.4-1.0
Locomotor activity1.11.72.3-1.51.41.51.51.5-0.41.5-1.4-1.2-1.21.41.31.2
Locomotor testing distance2.84.75.9-2.42.42.42.42.4-1.62.3-2.3-2.1-2.12.12.01.5
Locomotor testing rearing2.33.64.1-2.02.02.02.02.0-1.62.0-2.0-2.0-1.91.91.81.3
Locomotion in novel chamber0.50.71.11.1-1.0-1.0-0.9-0.90.9-0.80.70.80.8-0.4-0.30.6
Locomotion in novel chamber post-restriction0.10.10.30.3-0.2-0.3-0.2-0.20.2-0.20.10.10.20.10.10.6
Fecal boli incidents, locomotor time 12.12.32.8-1.61.61.61.61.6-1.31.6-1.6-1.7-1.41.51.51.3
Change in fecal boli incidents, locomotor task1.71.62.01.2-1.2-1.2-1.2-1.20.9-1.31.41.21.4-1.3-1.3-1.4
Time >=10cm from walls, locomotor time 10.20.21.00.2-0.3-0.2-0.3-0.3-0.1-0.30.40.40.3-0.6-0.7-1.0
Bouts of movement, locomotor time 10.00.00.10.1-0.1-0.1-0.1-0.10.1-0.10.2-0.0-0.0-0.1-0.1-0.2
Total resting periods, locomotor time 10.20.20.3-0.50.50.40.40.4-0.60.4-0.3-0.5-0.50.30.3-0.1
Rest time, locomotor task time 10.40.40.6-0.70.70.70.70.7-0.70.6-0.5-0.8-0.70.50.50.2
Distance moved, locomotor task time 10.00.10.20.1-0.2-0.2-0.2-0.20.0-0.20.10.20.3-0.3-0.3-0.5
Vertical activity count, locomotor time 11.31.42.11.2-1.2-1.1-1.1-1.21.3-1.11.01.31.5-1.1-1.2-0.9
Time >=10cm from walls, locomotor time 20.60.70.8-0.80.80.80.80.8-0.60.8-0.9-0.8-0.70.90.90.9
Bouts of movement, locomotor time 22.52.73.31.8-1.8-1.8-1.7-1.71.8-1.71.71.61.7-1.5-1.4-0.9
Total resting periods, locomotor time 22.93.13.61.9-1.9-1.9-1.9-1.91.9-1.81.81.71.8-1.6-1.5-1.0
Rest time, locomotor task time 20.00.00.4-0.0-0.0-0.0-0.0-0.0-0.1-0.10.2-0.1-0.1-0.2-0.2-0.6
Distance moved, locomotor task time 20.00.00.1-0.20.20.20.20.2-0.10.2-0.2-0.1-0.10.20.20.1
Vertical activity count, locomotor time 20.10.10.30.1-0.1-0.1-0.1-0.10.2-0.0-0.10.40.40.10.00.6
Light reinforcement 12.95.25.9-2.22.22.32.32.3-1.92.3-2.4-2.2-2.22.42.42.4
Light reinforcement 20.91.32.8-0.91.01.01.01.0-0.01.1-1.2-1.1-1.01.31.41.7
Bone: marrow area7.616.518.14.3-4.2-4.2-4.2-4.24.0-4.24.14.24.2-4.0-3.8-3.0
Bone: maximum diameter3.25.87.62.5-2.5-2.4-2.4-2.42.2-2.42.42.82.6-2.5-2.6-1.8
Bone: maximum force14.825.528.85.3-5.3-5.3-5.3-5.35.4-5.25.15.05.1-4.8-4.6-3.6
Bone: maximum moment15.727.031.05.5-5.4-5.5-5.5-5.45.6-5.45.35.15.2-4.9-4.7-3.7
Mean time between licks in bursts0.00.00.1-0.20.20.10.20.20.20.2-0.1-0.2-0.20.20.2-0.1
Mean num. licks in bursts0.10.10.90.4-0.3-0.4-0.3-0.30.9-0.30.30.20.2-0.10.10.3
Cd content in liver0.80.91.2-0.90.90.91.00.9-1.11.0-1.0-0.8-0.90.90.90.8
Co content in liver0.91.01.7-1.01.01.11.11.0-0.61.1-1.0-0.9-0.91.11.01.3
Cu content in liver0.50.71.00.8-0.8-0.8-0.9-0.80.4-0.91.00.50.6-0.9-0.9-1.0
Fe content in liver0.50.60.9-0.80.80.80.80.8-0.70.7-0.8-0.8-1.00.60.50.3
K content in liver0.20.20.70.3-0.3-0.3-0.3-0.30.2-0.40.40.10.4-0.5-0.6-0.8
Mg content in liver0.00.00.2-0.20.20.20.20.2-0.40.2-0.2-0.1-0.00.10.00.0
Mn content in liver0.10.10.20.4-0.4-0.4-0.4-0.40.5-0.40.30.20.3-0.4-0.3-0.4
Na content in liver0.10.10.2-0.30.30.30.30.3-0.40.3-0.2-0.4-0.40.20.2-0.2
Rb content in liver0.60.72.0-1.00.91.00.90.9-1.40.8-0.8-0.8-0.80.50.4-0.0
Se content in liver0.81.02.5-1.11.11.11.11.1-1.61.0-1.1-1.0-0.90.70.60.3
Sr content in liver0.20.20.70.4-0.4-0.3-0.3-0.4-0.0-0.30.20.90.6-0.4-0.5-0.1
Zn content in liver2.22.53.0-1.71.61.71.71.7-1.71.6-1.6-1.5-1.61.41.31.1
Bone: minimum diameter8.716.318.74.3-4.3-4.2-4.2-4.24.1-4.14.14.34.1-3.9-3.8-2.6
Time in familiar zone, hab. session 10.30.20.4-0.40.40.40.40.4-0.30.5-0.4-0.6-0.60.60.60.7
Time in novel zone, hab. session 10.20.20.40.4-0.5-0.4-0.5-0.50.3-0.50.50.50.5-0.6-0.6-0.6
Total zone transitions, hab. session 10.30.40.6-0.60.70.60.60.6-0.50.6-0.6-0.6-0.70.70.70.6
Total locomotion distance, hab. session 10.10.11.0-0.0-0.0-0.0-0.0-0.1-0.2-0.10.10.20.2-0.3-0.4-1.0
Locomotion velocity, hab. session 10.10.11.00.1-0.1-0.1-0.1-0.2-0.1-0.20.20.30.3-0.4-0.4-1.0
Time in familiar zone, hab. session 20.40.40.80.8-0.7-0.8-0.7-0.70.9-0.70.60.60.6-0.4-0.30.1
Time in novel zone, hab. session 20.30.30.9-0.70.70.70.60.6-0.90.5-0.5-0.5-0.60.20.1-0.4
Total zone transitions, hab. session 20.30.40.5-0.60.60.60.60.6-0.70.6-0.6-0.5-0.60.60.60.5
Total locomotion distance, hab. session 20.10.10.4-0.40.30.30.30.3-0.60.3-0.3-0.2-0.20.10.1-0.4
Locomotion velocity, hab. session 20.00.00.2-0.20.20.10.20.1-0.50.1-0.2-0.1-0.00.0-0.0-0.4
Novel to familiar place preference ratio1.61.71.91.4-1.4-1.4-1.4-1.41.2-1.41.41.11.2-1.3-1.3-1.0
Novelty place preference1.21.21.41.1-1.1-1.1-1.2-1.10.9-1.21.21.01.0-1.2-1.1-1.0
Time in novel zone, NPP test1.01.01.21.0-1.0-1.0-1.1-1.00.7-1.11.10.90.9-1.1-1.1-1.0
Total zone transitions, NPP test1.31.82.5-1.61.51.51.51.5-1.61.4-1.3-1.3-1.31.11.00.3
Total locomotion distance, NPP test1.52.13.8-1.71.61.61.61.6-2.01.5-1.5-1.4-1.41.21.10.1
Locomotion velocity, NPP test0.91.22.5-1.31.21.21.21.2-1.61.1-1.1-1.0-1.00.80.8-0.0
Intraocular pressure7.410.311.2-3.33.33.33.33.3-3.03.3-3.3-3.2-3.23.23.22.6
Delta distance traveled before/after self-admin0.10.10.10.3-0.3-0.3-0.3-0.30.0-0.30.40.30.4-0.2-0.2-0.0
Delta ambulatory time before/after self-admin0.00.00.10.1-0.1-0.1-0.0-0.0-0.2-0.00.00.10.10.10.10.3
Parametrial fat weight2.24.34.7-2.12.12.12.12.1-2.12.1-2.1-2.2-2.12.12.01.8
Pavlov. Cond. lever latency0.30.42.60.3-0.3-0.4-0.5-0.40.1-0.50.70.30.3-0.8-0.7-1.6
Pavlov. Cond. magazine entry latency0.10.10.60.2-0.2-0.2-0.2-0.20.7-0.10.0-0.00.10.20.30.7
Pavlov. Cond. change in total contacts0.20.21.60.2-0.2-0.1-0.1-0.10.7-0.0-0.10.10.10.30.41.3
Pavlov. Cond. index score0.10.21.50.2-0.1-0.1-0.0-0.00.50.1-0.20.00.10.40.31.2
Pavlov. Cond. latency score0.10.21.70.1-0.00.00.10.10.30.2-0.3-0.00.10.40.41.3
Pavlov. Cond. lever contacts0.91.04.0-0.70.70.80.80.8-0.30.9-1.0-0.8-0.81.21.22.0
Pavlov. Cond. magazine entry number0.10.10.70.1-0.1-0.1-0.1-0.1-0.4-0.20.30.20.2-0.4-0.4-0.9
Pavlov. Cond. intertrial magazine entries0.50.62.3-0.90.80.90.80.8-1.50.6-0.5-0.5-0.60.1-0.1-1.1
Pavlov. Cond. lever-magazine prob. diff.0.20.20.80.5-0.4-0.4-0.3-0.40.8-0.30.20.30.40.00.00.9
Pavlov. Cond. response bias0.20.21.2-0.20.20.30.30.30.30.4-0.4-0.3-0.30.60.61.1
Pavlov. Cond. lever latency0.10.21.80.3-0.3-0.3-0.3-0.31.3-0.20.20.20.10.00.10.5
Pavlov. Cond. magazine entry latency1.21.43.20.9-1.0-1.0-1.0-1.0-0.0-1.11.21.21.2-1.4-1.5-1.8
Pavlov. Cond. change in total contacts1.01.41.71.3-1.3-1.2-1.2-1.20.4-1.21.21.11.3-1.3-1.3-0.9
Pavlov. Cond. index score0.50.72.20.5-0.6-0.6-0.6-0.6-0.7-0.70.70.70.8-1.0-1.2-1.5
Pavlov. Cond. latency score0.60.72.20.6-0.6-0.6-0.6-0.7-0.7-0.70.80.80.8-1.1-1.2-1.5
Pavlov. Cond. lever contacts0.30.42.2-0.60.50.50.50.5-1.50.5-0.5-0.5-0.40.30.2-0.1
Pavlov. Cond. magazine entry number2.12.64.9-1.41.51.41.51.5-0.31.6-1.6-1.7-1.71.92.02.2
Pavlov. Cond. intertrial magazine entries5.26.87.5-2.52.62.62.62.6-2.02.7-2.7-2.6-2.72.72.72.7
Pavlov. Cond. lever-magazine prob. diff.0.91.12.70.8-0.9-0.9-0.9-0.9-0.4-1.01.01.01.0-1.3-1.4-1.6
Pavlov. Cond. response bias0.10.11.3-0.20.20.20.20.2-1.10.1-0.1-0.1-0.1-0.1-0.1-0.4
Time in closed arm before self-admin1.41.62.01.3-1.3-1.3-1.3-1.31.3-1.31.31.31.4-1.2-1.2-0.9
Time in closed arm after self-admin0.70.70.90.9-0.9-0.9-0.9-0.90.7-0.90.80.91.0-0.8-0.8-0.6
Time in open arm before self-admin0.80.81.50.8-0.8-0.8-0.8-0.81.2-0.90.80.80.8-1.0-1.0-1.1
Time in open arm after self-admin0.20.30.5-0.60.50.50.50.5-0.20.5-0.5-0.7-0.70.50.50.2
Bone: periosteal estimation11.423.526.85.1-5.1-5.0-5.0-5.04.8-4.94.85.25.1-4.7-4.7-3.4
Bone: periosteal perimeter9.616.018.24.3-4.2-4.2-4.2-4.24.0-4.14.04.34.1-3.9-3.8-2.5
Bone: post-yield work9.012.213.53.6-3.6-3.7-3.7-3.63.6-3.63.63.53.5-3.4-3.2-2.7
Progressive ratio test 1 active lever presses4.95.16.5-2.52.52.62.52.5-2.52.4-2.4-2.1-2.22.01.81.0
Progressive ratio test 1 breakpoint4.54.75.9-2.42.42.42.42.3-2.42.3-2.3-2.0-2.11.91.81.1
Progressive ratio test 1 inactive lever presses3.53.94.1-2.02.02.02.02.0-1.72.0-1.9-2.0-1.92.02.01.7
Progressive ratio test 2 active lever presses2.62.83.4-1.71.71.81.81.7-1.61.8-1.8-1.8-1.51.71.61.3
Progressive ratio test 2 breakpoint3.33.74.3-2.02.02.02.02.0-1.82.0-2.1-2.0-1.81.91.91.5
Progressive ratio test 2 inactive lever presses2.63.03.5-1.71.81.71.81.8-1.51.8-1.8-1.9-1.51.81.81.6
Incentive Sensitization - Responses0.10.10.30.1-0.1-0.1-0.0-0.00.30.0-0.10.10.40.20.20.6
Incentive Sensitization - Breakpoint0.10.10.4-0.00.00.10.10.10.20.2-0.2-0.10.30.30.30.6
Sum of active levers in priming session hrs 5-60.10.10.4-0.20.20.20.20.2-0.60.1-0.0-0.3-0.2-0.1-0.1-0.6
Progressive ratio0.10.10.5-0.40.30.40.40.3-0.70.3-0.3-0.1-0.10.1-0.0-0.2
Food seeking constrained by brief footshock0.40.50.7-0.80.80.80.80.8-0.60.7-0.7-0.6-0.70.50.4-0.0
Seeking ratio, punishment vs. effort0.00.00.20.00.0-0.0-0.00.00.40.0-0.0-0.2-0.20.10.20.2
Retroperitoneal fat weight0.61.92.8-1.51.51.51.51.5-1.71.4-1.4-1.3-1.31.21.10.7
Reaction time number correct1.82.53.01.6-1.6-1.6-1.6-1.61.4-1.61.61.61.7-1.6-1.5-1.3
Reaction time mean minus median8.411.111.8-3.43.43.43.43.4-3.43.4-3.4-3.4-3.43.33.22.6
Reaction time mean minus median AUC5.97.68.6-2.82.82.82.82.8-2.92.8-2.8-2.9-2.92.72.72.0
Reaction time num false alarms1.62.22.5-1.51.51.51.51.5-1.61.5-1.5-1.5-1.51.41.31.0
Reaction time num false alarms AUC2.23.03.3-1.81.81.81.81.8-1.71.8-1.8-1.8-1.81.71.71.2
Reaction time trials correct on left1.82.53.01.6-1.6-1.6-1.6-1.61.4-1.61.61.61.7-1.6-1.5-1.3
Reaction time trials on left1.42.02.41.4-1.5-1.5-1.5-1.51.2-1.51.41.51.6-1.4-1.4-1.2
Reaction time mean0.71.01.3-1.11.11.11.11.1-0.91.0-1.1-1.1-0.90.90.90.6
Reaction time mean AUC0.40.50.7-0.80.80.80.80.8-0.50.8-0.9-0.9-0.70.70.60.5
Median of all reaction times0.00.00.1-0.0-0.00.00.00.00.2-0.0-0.1-0.00.2-0.1-0.1-0.2
Reaction time omissions9.412.914.3-3.83.83.83.73.7-3.43.7-3.8-3.6-3.63.53.42.7
Reaction time false alarm rate2.83.94.4-2.02.02.02.02.0-1.82.0-2.0-2.1-2.11.91.91.5
Reaction time premature initiation rate6.89.19.9-3.03.13.13.13.1-2.53.1-3.1-2.9-3.03.13.13.0
Reaction time premature initiations2.94.14.7-2.02.02.12.12.1-1.62.1-2.1-1.9-2.02.22.12.2
Std. dev. reaction times6.18.59.3-3.13.03.03.03.0-3.03.0-3.0-3.0-3.02.82.72.0
Reaction time trials completed1.42.02.41.4-1.5-1.5-1.5-1.51.2-1.51.41.51.6-1.4-1.4-1.2
Reaction time trials AUC2.23.13.61.8-1.8-1.8-1.8-1.81.5-1.81.81.81.9-1.8-1.7-1.5
Run reversals in cocaine runway, females0.10.10.50.2-0.1-0.2-0.1-0.10.2-0.10.1-0.1-0.00.20.30.7
Run reversals in cocaine runway, males1.61.62.8-1.21.21.21.21.2-1.71.2-1.2-1.1-1.21.21.21.2
Latency to leave start box in cocaine runway0.00.00.1-0.10.10.10.10.10.30.1-0.2-0.1-0.10.20.10.3
Latency to leave start box in cocaine runway, F1.71.82.1-1.41.41.51.41.4-0.81.4-1.4-1.3-1.41.31.31.0
Latency to leave start box in cocaine runway, M1.81.82.21.5-1.5-1.5-1.4-1.41.1-1.41.41.41.4-1.3-1.2-0.7
Std. dev. time between licks in bursts1.21.41.7-1.31.21.31.31.3-1.11.3-1.3-1.0-1.01.21.10.9
Total sessions with >9 infusions1.31.42.0-1.21.21.31.31.3-1.21.3-1.4-0.8-0.91.21.01.2
Short access day 1 total inactive lever presses1.71.92.0-1.41.41.41.41.4-1.41.4-1.4-1.4-1.41.41.31.1
Short access day 10 total inactive lever presses0.10.20.5-0.30.30.20.30.3-0.20.3-0.2-0.7-0.60.40.60.3
Short access day 1 total infusions0.10.10.2-0.40.40.50.40.4-0.50.4-0.5-0.2-0.20.20.10.0
Short access day 10 total infusions1.31.42.2-1.31.31.41.31.3-1.51.3-1.3-0.9-1.01.00.80.6
Short access total infusions0.80.91.4-1.11.01.11.11.0-1.21.0-1.1-0.6-0.70.90.70.7
Short access day 1 locomotion0.20.20.3-0.50.50.50.50.5-0.50.4-0.5-0.3-0.30.40.30.3
Short access day 10 total locomotion0.10.10.3-0.40.40.40.40.4-0.50.3-0.3-0.4-0.50.30.30.1
Short access total locomotion0.50.50.8-0.80.80.80.80.8-0.90.7-0.7-0.7-0.70.70.70.6
One hour access (0.3 mA shock)0.50.62.3-0.50.60.60.70.6-0.30.7-0.8-0.5-0.50.90.91.5
Compulsive drug intake1.11.11.41.2-1.1-1.2-1.2-1.11.2-1.11.10.90.9-0.9-0.8-0.6
One hour access (shock baseline)0.40.41.5-0.50.50.60.60.6-0.30.6-0.7-0.3-0.30.80.71.2
Social response proportion0.20.20.2-0.40.40.40.40.4-0.20.4-0.4-0.4-0.40.50.40.5
Social responses8.010.311.1-3.33.33.33.33.3-3.13.3-3.2-3.2-3.33.23.12.6
Social time0.00.10.30.1-0.1-0.1-0.1-0.10.6-0.10.2-0.1-0.10.10.20.4
Soleus weight0.61.83.01.5-1.4-1.5-1.4-1.41.7-1.41.41.21.2-1.1-1.0-0.5
Bone: stiffness17.026.831.75.5-5.5-5.5-5.4-5.45.6-5.35.25.35.3-4.9-4.7-3.3
Tibialis anterior weight0.72.56.41.9-1.8-1.8-1.7-1.72.5-1.61.41.31.3-0.9-0.70.8
Time to tail flick, vehicle, before self-admin0.80.81.0-0.90.90.90.90.9-1.00.9-0.9-0.8-0.90.90.90.6
Time to tail flick, vehicle, after self-admin0.30.30.50.6-0.6-0.6-0.6-0.60.7-0.60.50.50.6-0.4-0.3-0.1
Time to tail flick, test, before self-admin0.20.20.4-0.40.50.40.40.4-0.10.4-0.4-0.6-0.50.50.50.4
Time to tail flick, test, after self-admin0.30.30.90.6-0.6-0.6-0.6-0.60.9-0.50.50.50.6-0.3-0.20.1
Delta time to tail flick, vehicle, before/after SA0.40.40.60.7-0.7-0.7-0.7-0.70.8-0.60.70.60.6-0.5-0.4-0.1
Delta time to tail flick, test, before/after SA0.20.10.30.5-0.4-0.4-0.4-0.40.2-0.40.30.50.4-0.2-0.20.3
Tibia length6.719.021.24.5-4.5-4.4-4.4-4.54.2-4.44.44.64.6-4.4-4.4-3.5
Ambulatory time before self-admin3.73.84.8-2.22.12.12.12.1-1.82.0-1.9-2.2-2.21.81.70.9
Ambulatory time after self-admin1.92.02.4-1.61.51.51.51.5-1.61.5-1.4-1.4-1.41.31.30.9
Bone: tissue strength1.51.52.51.3-1.2-1.3-1.3-1.31.6-1.31.31.01.1-1.1-1.0-1.0
Total heroin consumption1.82.22.41.5-1.5-1.5-1.5-1.51.5-1.51.61.41.4-1.5-1.4-1.2
Bone: trabecular number6.710.511.03.3-3.3-3.3-3.3-3.33.0-3.33.23.33.3-3.3-3.2-2.8
Bone: trabecular spacing2.63.33.9-1.81.81.81.81.8-2.01.9-1.8-1.8-1.71.81.81.7
Bone: trabecular thickness0.20.21.5-0.10.20.20.20.20.50.3-0.4-0.2-0.30.60.71.2
Bone: trabecular tissue density0.20.21.7-0.00.10.10.10.10.20.2-0.3-0.1-0.20.60.71.3
Water consumed over 24 hours0.00.00.20.1-0.1-0.1-0.1-0.1-0.2-0.10.10.30.3-0.2-0.3-0.4
Number of responses in last shaping day0.00.00.20.2-0.1-0.1-0.1-0.10.4-0.1-0.00.00.10.10.20.4