Kat7

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	mRNA stability	Kat7	0.05	0.03	2.3e-05	0.03	0.03	0.03	0.03	2.3e-04	2.6e-04	4.0e-04	1.9e-04
2	Brain	mRNA stability	Kat7	0.05	0.03	1.2e-03	0.02	0.03	0.03	0.03	2.4e-03	5.2e-04	1.2e-03	2.1e-03
3	NAcc	intron excision ratio	chr10_80237853_80240736	0.03	0.02	4.1e-03	0.02	0.01	0.01	0.01	1.5e-03	1.7e-02	2.3e-02	1.3e-02
4	NAcc	intron excision ratio	chr10_80236047_80240736	0.04	0.03	3.7e-05	0.04	0.03	0.02	0.02	5.7e-05	4.3e-04	2.2e-03	7.0e-04
5	BLA	isoform ratio	XM_039086068.1	0.07	0.04	3.9e-03	0.05	0.04	0.04	0.04	1.6e-03	3.6e-03	3.9e-03	3.3e-03
6	PL	intron excision ratio	chr10_80236047_80240736	0.02	0.02	2.5e-03	0.01	0.01	0.01	0.01	9.2e-03	1.2e-02	6.7e-02	4.1e-02
7	Brain	isoform ratio	NM_001415103.1	0.06	0.04	6.6e-03	-0	0.01	0.01	0	3.9e-01	1.8e-02	4.8e-02	1.3e-01
8	NAcc	isoform ratio	XM_039086068.1	0.04	0.03	6.0e-03	0.01	0.01	0.02	0.01	1.0e-02	8.7e-03	4.5e-03	2.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8
Bone: apparent density	0.1	0.2	0.6	0.6	0.5	0.4	-0.4	0.2	0.4	0.4	-0.8
Area under the delay curve	0.0	0.0	0.1	0.1	0.1	0.1	-0.1	0.0	0.4	-0.2	-0.3
BMI with tail	2.9	9.5	30.5	1.7	4.5	1.4	-1.4	-1.2	3.9	-5.5	-1.4
BMI without tail	1.0	2.2	9.6	-0.8	0.3	-1.1	1.0	0.9	3.1	-1.9	0.7
Body weight	0.7	2.8	7.4	1.4	2.0	1.1	-1.1	-1.2	2.2	-2.7	-0.3
Weight adjusted by age	0.0	0.0	0.1	-0.2	0.0	-0.1	0.1	-0.2	0.0	-0.3	0.1
Bone surface	0.2	0.4	1.3	0.8	0.6	0.5	-0.5	-0.2	0.6	-0.3	-1.2
Bone volume	0.6	1.0	2.1	1.4	1.1	1.2	-1.2	-0.8	-0.0	-0.2	-1.1
Breakpoint value in progressive ratio session	1.8	1.9	4.9	-1.0	-1.4	-1.2	1.1	1.9	2.2	0.9	0.8
Number of licking bursts	1.5	1.7	2.7	-1.7	-1.6	-1.6	1.6	1.1	-0.4	1.1	1.0
Context. condit. distance diff. score	0.2	0.3	0.6	0.4	0.8	0.5	-0.4	-0.6	-0.5	-0.6	-0.3
Locomotion velocity, session 1	0.4	0.4	0.8	-0.7	-0.3	-0.8	0.8	0.1	0.5	-0.9	0.5
Locomotion distance, session 1	1.0	1.3	3.1	-1.8	-1.6	-1.5	1.4	0.7	0.5	-0.2	0.5
Locomotion velocity, session 2	0.3	0.4	1.3	0.4	0.1	0.6	-0.7	-0.7	-0.0	-0.4	-1.1
Locomotion distance, session 2	1.8	2.5	5.8	-2.4	-2.3	-1.8	1.6	1.3	0.9	0.2	-0.2
Locomotion velocity, session 3	1.8	2.0	2.8	1.5	1.6	1.7	-1.7	-1.6	0.1	-1.5	-0.9
Locomotion distance, session 3	0.2	0.3	0.8	-0.5	-0.7	-0.3	0.2	0.3	0.5	0.1	-0.9
Stereotopy head waving bouts, day 3	2.8	3.3	4.7	2.0	2.1	2.1	-2.2	-1.9	-1.6	-0.9	-1.5
Stereotopy head waving duration, day 3	2.4	2.9	4.1	1.9	1.9	2.0	-2.0	-1.9	-1.8	-0.6	-0.7
Locomotion velocity, session 7	0.4	0.5	1.6	0.1	0.2	0.5	-0.6	-1.2	-0.2	-1.3	0.3
Locomotion distance, session 7	1.3	1.7	3.9	-1.6	-2.0	-1.2	1.2	0.6	-1.0	1.3	1.0
Stereotopy head waving bouts, day 7	0.5	0.6	0.9	0.8	0.8	0.9	-1.0	-0.5	0.5	-0.7	-0.7
Stereotopy head waving duration, day 7	0.5	0.6	1.1	1.1	0.9	1.0	-1.0	-0.6	0.2	-0.5	-0.5
Locomotion velocity, session 8	1.4	1.6	6.2	0.6	1.4	0.8	-0.9	-1.2	0.8	-2.5	-1.0
Locomotion distance, session 8	0.3	0.5	1.2	-1.1	-0.7	-0.8	0.7	0.5	0.8	-0.5	0.1
Degree of sensitization distance	0.4	0.4	1.4	-0.1	-0.2	-0.1	0.1	-0.4	-1.2	0.3	1.1
Degree of sensitization stereotypy	0.4	0.4	1.2	-0.6	-0.6	-0.5	0.5	0.9	1.1	0.3	0.1
Conditioned locomotion	0.3	0.4	1.0	1.0	0.7	0.6	-0.5	-0.3	-0.8	0.5	-0.3
Cocaine response after cond. corrected	0.3	0.3	1.4	0.8	1.2	0.3	-0.3	-0.3	0.2	-0.5	0.2
Cocaine response after cond. not corrected	0.1	0.1	0.4	0.4	0.6	-0.1	0.1	0.2	-0.0	0.3	-0.0
Cocaine response before conditioning	1.0	1.3	3.3	-1.0	-1.5	-0.9	0.9	1.1	-0.6	1.8	-0.2
Saline control response	0.6	0.8	1.6	-1.1	-1.0	-1.0	0.9	1.3	0.5	0.6	-0.2
Bone: connectivity density	0.4	0.6	2.2	-0.1	-0.2	-0.3	0.3	1.3	1.5	0.7	-0.2
Bone: cortical apparent density	1.1	1.5	5.2	-0.8	-1.2	-0.5	0.5	-0.5	-2.3	1.0	1.7
Bone: cortical area	0.5	0.8	1.5	1.0	1.1	0.9	-0.9	-1.0	0.1	-1.2	-0.2
Bone: cortical porosity	0.5	0.5	2.1	0.4	0.6	0.5	-0.4	-0.5	0.4	-0.8	-1.4
Bone: cortical porosity	0.2	0.3	1.5	0.3	0.4	0.4	-0.4	-0.3	-0.0	-0.3	-1.2
Bone: cortical thickness	1.1	1.8	3.9	1.2	1.3	1.3	-1.3	-2.0	-1.5	-1.3	0.3
Bone: cortical thickness	0.2	0.2	0.9	-0.4	-0.2	-0.2	0.2	-0.2	-0.8	-0.1	0.9
Bone: cortical tissue density	1.2	1.6	5.0	-0.9	-1.4	-0.6	0.6	-0.3	-2.2	1.2	1.6
Condit. Reinf. active minus inactive responses	0.8	0.9	1.5	-1.2	-1.0	-1.1	1.1	1.0	1.2	-0.1	-0.4
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	-0.4	-0.1	-0.5	0.6	0.2	0.1	-0.3	-0.5
Condit. Reinf. active responses	1.0	1.2	2.4	-1.3	-1.1	-1.0	1.0	1.2	1.6	-0.0	-0.8
Condit. Reinf. inactive responses	1.1	1.3	2.2	-1.3	-1.4	-1.0	0.9	1.5	1.5	0.7	-0.5
Incentive salience index mean	1.6	2.0	3.6	-1.9	-1.5	-1.6	1.5	1.5	1.6	-0.1	-0.4
Condit. Reinf. lever presses	2.1	2.8	5.4	-2.3	-2.0	-1.9	1.8	1.8	1.5	0.4	-0.5
Condit. Reinf. active minus inactive responses	1.3	1.6	3.1	-1.2	-1.3	-1.3	1.3	1.8	1.3	1.0	1.0
Condit. Reinf. active-inactive response ratio	5.0	5.3	8.2	-2.4	-2.1	-2.8	2.8	2.9	1.8	1.4	1.6
Condit. Reinf. active responses	0.2	0.3	0.7	-0.6	-0.5	-0.3	0.3	0.8	0.8	0.1	0.0
Condit. Reinf. inactive responses	1.4	1.8	2.9	1.0	1.1	1.7	-1.7	-1.4	-0.8	-1.2	-1.5
Condit. Reinf. lever presses	0.4	0.6	2.2	0.4	0.5	0.6	-0.5	-0.4	1.1	-1.5	0.0
Condit. Reinf. lever reinforcers received	0.2	0.3	1.0	-0.5	-0.5	-0.3	0.3	0.9	1.0	0.1	-0.1
Conditioned reinforcement - actives	0.7	0.7	1.1	-1.0	-0.5	-1.0	1.0	0.9	1.0	-0.8	0.5
Conditioned reinforcement - inactives	0.4	0.4	1.1	-0.5	-0.6	-0.7	0.8	0.4	-1.0	0.6	-0.0
Conditioned locomotion	0.3	0.4	0.9	-1.0	-0.5	-0.8	0.8	0.6	0.3	-0.0	0.3
Patch foraging indifference point 0 sec	0.7	1.1	2.2	1.1	1.2	1.1	-1.1	-0.7	0.7	-0.5	-1.5
Patch foraging indifference point AUC	0.7	0.8	3.7	0.5	0.8	0.7	-0.7	-1.1	0.2	-1.9	-0.1
Delay disc. indifference point, 0s delay	0.1	0.1	0.5	-0.1	0.2	-0.2	0.1	-0.2	-0.2	-0.7	0.2
Delay disc. indifference point, 16s delay	0.7	0.7	1.4	1.0	1.2	0.8	-0.8	-0.6	0.6	-0.8	-0.8
Delay disc. indifference point, 2s delay	0.4	0.4	1.7	0.4	-0.3	0.2	-0.2	0.1	-0.9	1.3	-0.5
Delay disc. indifference point, 24s delay	0.7	0.7	1.9	-0.8	-0.4	-0.7	0.7	1.0	1.4	-0.8	0.4
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	0.3	-0.1	0.3	-0.3	-0.4	-0.3	0.4	-0.2
Delay disc. indifference point, 8s delay	0.0	0.0	0.2	-0.2	-0.3	-0.0	-0.0	0.0	-0.1	0.5	0.2
Indifference point function ln k	0.3	0.4	1.4	-0.4	-0.6	-0.6	0.6	0.5	-0.3	1.2	0.6
Indifference point function log k	0.3	0.4	1.4	-0.4	-0.6	-0.6	0.6	0.5	-0.3	1.2	0.6
Patch foraging total patch changes 0 sec	0.9	1.4	2.7	1.4	1.3	1.3	-1.3	-0.9	0.7	-0.5	-1.6
Patch foraging total patch changes 12 sec	0.2	0.3	1.9	0.1	0.1	0.4	-0.4	0.0	0.4	-0.3	-1.4
Patch foraging total patch changes 18 sec	1.8	2.3	3.2	1.5	1.8	1.5	-1.5	-1.6	0.4	-1.7	-1.7
Patch foraging total patch changes 24 sec	0.5	0.6	1.5	1.1	0.9	0.7	-0.7	-0.3	0.6	-0.3	-1.2
Patch foraging total patch changes 6 sec	1.3	1.9	4.1	1.2	1.5	1.1	-1.1	-0.9	1.3	-2.0	-1.5
Patch foraging time to switch 0 sec	0.2	0.2	0.4	-0.4	-0.6	-0.7	0.6	0.4	-0.5	0.5	-0.1
Patch foraging water rate 0 sec	0.9	1.5	3.0	1.1	1.7	1.4	-1.3	-1.3	0.0	-1.5	-0.6
Patch foraging water rate 12 sec	0.6	0.9	1.6	1.0	1.2	0.6	-0.6	-0.3	1.2	-1.3	-0.9
Patch foraging water rate 18 sec	0.2	0.3	1.2	-0.2	-0.3	-0.4	0.3	0.5	0.2	1.1	0.6
Patch foraging water rate 24 sec	0.3	0.4	1.0	0.7	1.0	0.5	-0.5	-0.6	0.2	-0.8	-0.2
Patch foraging water rate 6 sec	0.7	1.1	3.5	-0.9	-0.2	-0.9	1.0	1.2	1.9	-0.6	0.9
Seeking ratio, delayed vs. immediate footshock	0.5	0.6	1.1	1.0	1.1	0.9	-1.0	-0.4	0.1	-0.5	-0.6
Distance traveled before self-admin	3.9	4.2	6.1	-2.3	-2.1	-2.5	2.4	2.3	1.8	0.4	1.6
Distance traveled after self-admin	1.5	1.7	3.6	-1.4	-0.8	-1.5	1.5	1.9	1.4	0.3	-0.7
Extensor digitorum longus weight	0.9	3.7	7.6	2.1	2.5	1.8	-1.7	-1.6	1.7	-2.8	0.2
Bone: elastic displacement	0.1	0.2	0.8	-0.2	0.0	-0.2	0.2	0.0	0.4	-0.5	0.9
Bone: elastic work	0.1	0.1	0.6	0.1	0.1	0.1	-0.1	-0.2	0.4	-0.6	0.8
Bone: endosteal estimation	0.1	0.3	1.5	-0.0	-0.1	-0.1	0.1	0.7	1.2	-0.1	0.4
Bone: endosteal perimeter	0.2	0.5	2.6	0.2	0.1	0.1	-0.1	0.6	1.6	-0.2	-0.9
Epididymis fat weight	0.1	0.3	1.7	0.0	-0.1	-0.4	0.4	0.6	1.3	0.2	0.2
Delta time in closed arm before/after self-admin	0.6	0.5	1.0	0.8	0.8	0.8	-0.9	-1.0	-0.2	-0.6	-0.2
Delta time in open arm before/after self-admin	0.0	0.0	0.2	-0.0	0.1	-0.0	0.1	0.1	-0.5	0.0	-0.1
Diff in mean of infusions in LGA sessions	2.1	2.3	5.5	-1.6	-1.0	-1.5	1.5	1.8	2.3	-1.1	0.7
Delay discount exponential model param	0.0	0.0	0.2	0.0	-0.0	0.0	0.0	-0.1	-0.4	0.1	0.3
Extinction: sum of active levers before priming	0.2	0.2	0.8	0.4	-0.2	0.2	-0.2	0.1	0.9	-0.2	0.4
Active lever presses in extinction session 6	0.2	0.2	0.5	-0.1	0.3	-0.2	0.2	0.5	0.7	-0.6	-0.3
Bone: final force	0.1	0.1	0.7	-0.1	-0.1	-0.0	0.0	-0.1	-0.8	0.3	-0.0
Bone: final moment	0.1	0.1	0.6	0.0	0.1	0.0	-0.0	-0.2	-0.8	0.1	-0.2
Food consumed during 24 hour testing period	1.0	1.2	2.6	-1.0	-1.1	-1.2	1.2	1.1	1.6	0.0	1.0
Glucose	2.1	3.1	9.8	1.7	1.1	1.8	-1.8	-1.4	-3.1	1.3	-1.2
Heart weight	0.4	0.5	1.6	0.8	0.8	0.8	-0.6	-0.3	0.5	-0.2	-1.3
Delay discount hyperbolic model param	0.0	0.0	0.1	-0.1	0.0	-0.1	0.1	-0.0	-0.2	-0.1	0.3
Intermittent access intake day 1-15 change	1.1	1.1	5.3	0.2	0.6	0.1	0.0	0.0	2.3	-1.6	-0.8
Intermittent access intake escalation	1.1	1.1	5.1	0.2	0.5	0.2	-0.1	0.0	2.3	-1.5	-0.9
Intermittent access intake escalation 2	1.3	1.3	8.0	-0.5	0.1	-0.3	0.4	0.7	2.8	-1.2	-0.3
Intermitt. access day 1 inactive lever presses	0.6	0.6	1.1	-0.9	-0.8	-1.0	1.0	0.6	-0.1	0.7	0.6
Intermitt. access day 15 inactive lever presses	1.5	1.6	2.7	1.5	1.7	1.2	-1.2	-1.4	-0.4	-1.2	-1.3
Intermitt. access escalation Index	0.5	0.5	1.0	-0.8	-0.7	-0.7	0.8	1.0	0.4	0.4	0.3
Intermittent access day 1 total infusions	0.6	0.7	2.5	0.0	-0.7	-0.3	0.3	-0.3	-1.6	1.4	0.7
Intermittent access day 15 total infusions	0.2	0.3	0.9	-0.2	-0.5	-0.5	0.6	0.2	1.0	-0.3	0.3
Intermittent access terminal intake (last 3 days)	0.2	0.2	1.0	-0.2	-0.4	-0.4	0.5	0.0	1.0	-0.2	0.6
Intermittent access total infusions	0.1	0.2	0.8	0.1	-0.3	-0.2	0.2	-0.3	-0.2	0.3	0.9
Intermittent access day 1 locomotion	1.0	1.0	2.6	-0.6	-1.3	-0.9	0.9	0.5	-1.2	1.6	0.6
Intermittent access day 15 total locomotion	0.1	0.1	0.2	-0.1	-0.4	-0.2	0.2	0.2	0.4	-0.2	-0.3
Intermittent access total locomotion	0.1	0.1	0.4	-0.3	-0.6	-0.5	0.5	0.3	-0.1	0.2	-0.0
Intermittent access standard deviation	1.4	1.5	4.7	0.5	0.9	0.4	-0.4	-0.4	2.2	-2.0	-1.3
Left kidney weight	0.3	0.7	1.5	0.7	0.5	1.2	-1.2	-1.0	-1.0	0.3	0.4
Right kidney weight	0.9	2.6	5.1	1.8	1.7	2.3	-2.2	-1.9	-0.8	-0.8	-0.3
Cocaine induced anxiety	0.9	1.0	2.4	-1.0	-0.5	-1.0	1.1	0.8	1.6	-0.8	1.0
Post-drug Anxiety	1.7	1.9	3.1	-1.5	-1.3	-1.8	1.7	1.3	1.5	-0.2	1.0
Baseline Anxiety	0.2	0.2	0.5	0.7	0.2	0.3	-0.6	-0.3	-0.3	0.6	-0.3
Tail length	2.3	7.0	18.9	-2.0	-4.3	-2.1	2.1	1.6	-0.7	4.0	2.3
Length with tail	0.6	2.3	8.6	0.5	-2.0	0.3	-0.3	-0.7	-1.9	2.9	1.0
Length without tail	1.4	3.0	5.2	2.0	1.3	2.1	-2.1	-2.3	-2.0	-0.1	-0.8
Times rat made contact with spout	0.4	0.5	0.9	-0.6	-1.0	-0.7	0.7	0.5	0.0	0.9	0.6
Lifetime Intake	0.1	0.2	0.5	0.1	-0.3	-0.2	0.2	-0.2	-0.7	0.6	0.6
Liver weight, left	0.2	0.4	1.2	-0.1	-0.8	-0.5	0.5	0.7	0.3	1.1	-0.1
Liver weight, right	0.4	0.7	1.4	1.0	0.2	0.9	-0.9	-0.7	-0.5	0.5	1.2
Locomotor activity	0.4	0.6	2.1	-1.4	-0.4	-0.7	0.7	0.8	0.4	-0.9	0.3
Locomotor testing distance	0.6	0.9	2.5	-1.6	-0.6	-1.1	1.2	1.1	0.5	-0.5	0.5
Locomotor testing rearing	0.8	1.3	2.8	-1.7	-0.7	-1.4	1.4	1.2	0.7	-0.7	0.9
Locomotion in novel chamber	1.4	1.7	2.8	-1.3	-1.4	-1.3	1.2	1.7	1.4	1.3	0.7
Locomotion in novel chamber post-restriction	0.1	0.1	0.2	0.1	0.0	0.3	-0.4	-0.1	-0.4	0.5	0.2
Fecal boli incidents, locomotor time 1	1.7	1.9	3.9	1.3	2.0	1.4	-1.4	-1.4	0.2	-1.8	0.3
Change in fecal boli incidents, locomotor task	1.1	1.1	1.7	-1.0	-1.3	-1.2	1.2	1.0	-0.4	1.0	0.8
Time >=10cm from walls, locomotor time 1	2.5	2.6	5.2	-1.8	-1.3	-2.0	1.9	1.4	0.9	0.5	2.3
Bouts of movement, locomotor time 1	2.5	2.7	3.6	1.1	1.7	1.6	-1.7	-1.8	-1.5	-1.8	-1.9
Total resting periods, locomotor time 1	2.8	3.0	4.0	1.2	1.8	1.7	-1.8	-2.0	-1.5	-1.7	-2.0
Rest time, locomotor task time 1	0.3	0.3	0.6	0.4	0.5	0.7	-0.6	-0.6	-0.8	-0.2	-0.3
Distance moved, locomotor task time 1	2.8	3.1	4.6	-1.5	-2.0	-2.0	1.9	2.1	0.5	1.8	1.6
Vertical activity count, locomotor time 1	0.9	0.9	1.6	-0.8	-0.7	-1.1	1.0	0.9	1.3	-0.7	1.1
Time >=10cm from walls, locomotor time 2	1.3	1.3	2.3	-1.3	-1.2	-1.5	1.4	1.1	-0.6	1.2	0.6
Bouts of movement, locomotor time 2	0.2	0.2	0.5	-0.6	-0.0	-0.4	0.2	0.3	0.7	-0.5	-0.2
Total resting periods, locomotor time 2	0.2	0.3	0.8	-0.7	-0.1	-0.4	0.3	0.4	0.9	-0.5	-0.2
Rest time, locomotor task time 2	0.4	0.4	2.1	-0.3	-0.8	-0.3	0.4	0.8	-0.1	1.4	-0.1
Distance moved, locomotor task time 2	0.4	0.5	2.6	0.5	0.2	0.2	-0.3	-0.5	-1.6	0.3	-0.8
Vertical activity count, locomotor time 2	0.4	0.4	2.3	0.2	0.5	-0.0	-0.1	-0.6	-0.1	-1.5	0.5
Light reinforcement 1	0.5	0.9	2.7	-1.0	-0.6	-1.0	0.9	1.1	1.7	-0.3	-0.4
Light reinforcement 2	0.8	1.1	1.8	-1.2	-1.1	-1.3	1.2	1.3	0.9	0.3	0.5
Bone: marrow area	0.1	0.3	1.5	-0.1	-0.2	-0.2	0.2	0.7	1.2	-0.1	0.5
Bone: maximum diameter	0.2	0.4	2.3	0.2	0.3	0.0	-0.0	0.5	1.5	-0.5	-0.2
Bone: maximum force	0.3	0.5	0.8	0.9	0.9	0.8	-0.8	-0.8	-0.5	-0.5	-0.1
Bone: maximum moment	0.4	0.7	1.1	1.0	1.0	0.9	-0.9	-1.0	-0.6	-0.7	-0.2
Mean time between licks in bursts	1.6	2.2	3.4	1.7	1.6	1.7	-1.7	-1.8	-0.9	-1.3	-0.7
Mean num. licks in bursts	0.6	0.7	1.5	1.2	0.8	1.1	-1.1	-0.7	0.3	-0.2	-0.8
Cd content in liver	3.0	3.3	7.0	-1.7	-2.0	-1.8	1.8	2.7	1.7	1.6	0.2
Co content in liver	0.1	0.2	0.5	-0.7	-0.2	-0.2	0.2	0.1	0.2	-0.7	-0.2
Cu content in liver	4.0	4.9	8.2	-2.9	-2.9	-2.4	2.4	1.9	1.3	0.5	2.3
Fe content in liver	0.9	1.1	2.4	-0.9	-1.5	-0.9	0.9	1.1	-0.2	1.5	0.6
K content in liver	1.1	1.1	3.8	0.7	0.1	1.1	-1.1	-1.2	-1.9	0.2	0.4
Mg content in liver	0.6	0.6	2.9	-0.1	-0.8	0.3	-0.3	-0.6	-1.7	0.9	0.2
Mn content in liver	1.1	1.3	1.9	-1.4	-1.4	-1.1	1.1	1.1	1.3	0.1	1.0
Na content in liver	0.3	0.3	0.9	0.2	-0.1	0.7	-0.7	-0.5	-0.9	0.3	-0.2
Rb content in liver	0.2	0.2	0.5	-0.3	-0.6	-0.7	0.7	0.3	-0.3	0.4	-0.4
Se content in liver	0.4	0.5	2.2	0.0	-0.5	-0.2	0.2	0.6	-0.8	1.5	0.4
Sr content in liver	0.3	0.2	0.4	0.6	0.0	0.6	-0.6	-0.4	-0.3	0.4	0.6
Zn content in liver	0.6	0.7	1.4	-1.1	-1.2	-0.5	0.5	0.9	-0.0	1.1	-0.3
Bone: minimum diameter	0.2	0.4	0.9	0.9	0.2	0.8	-0.8	-0.1	-0.4	1.0	-0.4
Time in familiar zone, hab. session 1	1.8	1.7	4.1	-1.0	-1.4	-1.4	1.4	1.3	-0.6	2.0	0.8
Time in novel zone, hab. session 1	3.3	3.3	4.8	1.9	2.2	2.1	-2.1	-1.7	0.3	-1.9	-1.4
Total zone transitions, hab. session 1	3.0	4.1	6.9	-2.6	-2.5	-2.3	2.3	1.9	1.9	0.2	1.5
Total locomotion distance, hab. session 1	1.5	2.2	4.3	-2.1	-2.0	-1.5	1.3	1.5	1.8	0.1	0.3
Locomotion velocity, hab. session 1	1.8	2.6	5.4	-2.3	-2.3	-1.7	1.5	1.6	1.4	0.3	0.4
Time in familiar zone, hab. session 2	0.2	0.2	1.1	0.3	0.6	0.0	0.0	0.3	1.1	-0.5	-0.0
Time in novel zone, hab. session 2	0.3	0.3	1.6	-0.2	-0.4	-0.0	-0.1	-0.3	-1.3	0.6	-0.7
Total zone transitions, hab. session 2	2.1	2.7	4.8	-2.2	-2.2	-1.9	1.7	1.6	1.0	0.6	1.1
Total locomotion distance, hab. session 2	0.3	0.3	1.0	-1.0	-1.0	-0.3	0.1	0.5	0.5	-0.1	-0.5
Locomotion velocity, hab. session 2	0.2	0.3	0.9	-0.9	-1.0	-0.3	0.0	0.4	0.3	0.1	-0.5
Novel to familiar place preference ratio	0.9	1.0	2.1	-1.1	-1.0	-0.9	0.8	1.5	1.0	0.9	0.4
Novelty place preference	0.7	0.7	1.5	-1.0	-0.9	-0.8	0.7	1.2	0.7	0.8	0.3
Time in novel zone, NPP test	0.6	0.7	1.3	-1.0	-0.9	-0.8	0.8	1.2	0.4	0.9	0.1
Total zone transitions, NPP test	2.2	3.1	6.9	-2.6	-2.6	-2.0	1.9	1.6	0.6	0.8	0.3
Total locomotion distance, NPP test	0.6	0.8	2.5	-1.6	-1.4	-0.8	0.6	0.5	0.1	-0.1	-0.8
Locomotion velocity, NPP test	0.4	0.6	1.9	-1.4	-1.3	-0.6	0.4	0.3	0.3	-0.3	-0.7
Intraocular pressure	0.6	0.9	1.3	-1.1	-1.0	-1.1	1.1	0.7	0.9	-0.1	1.0
Delta distance traveled before/after self-admin	1.3	1.4	5.7	0.9	1.3	1.0	-1.1	-0.8	-0.5	-0.5	-2.4
Delta ambulatory time before/after self-admin	1.4	1.5	5.8	1.0	1.3	1.1	-1.1	-0.9	-0.8	-0.3	-2.4
Parametrial fat weight	1.4	2.7	7.2	-1.1	-1.7	-1.5	1.5	1.6	-0.6	2.7	1.6
Pavlov. Cond. lever latency	2.2	2.8	6.1	2.5	1.9	2.1	-2.0	-1.8	-0.8	-0.4	-0.4
Pavlov. Cond. magazine entry latency	0.9	1.2	2.4	-1.6	-0.8	-1.3	1.3	1.1	1.1	-0.4	0.4
Pavlov. Cond. change in total contacts	4.2	4.4	7.3	-2.7	-2.4	-2.6	2.6	2.3	1.4	0.9	1.1
Pavlov. Cond. index score	2.2	2.7	6.3	-2.5	-1.6	-2.2	2.1	1.6	1.0	-0.2	0.5
Pavlov. Cond. latency score	1.8	2.3	5.7	-2.4	-1.5	-2.0	1.9	1.4	0.7	-0.2	0.4
Pavlov. Cond. lever contacts	2.7	3.1	7.5	-2.7	-2.1	-2.3	2.1	1.7	0.7	0.2	0.5
Pavlov. Cond. magazine entry number	1.2	1.6	3.1	1.8	1.2	1.6	-1.6	-1.3	-1.0	0.1	-0.4
Pavlov. Cond. intertrial magazine entries	0.6	0.7	2.4	-0.3	-1.2	-0.4	0.4	0.9	0.4	1.6	-0.7
Pavlov. Cond. lever-magazine prob. diff.	2.2	2.7	5.9	-2.4	-1.5	-2.2	2.1	1.6	1.0	-0.2	0.8
Pavlov. Cond. response bias	2.0	2.5	4.6	-2.2	-1.4	-2.0	1.9	1.7	1.5	-0.3	0.6
Pavlov. Cond. lever latency	2.5	3.4	5.1	-2.1	-2.3	-2.0	2.0	1.9	-0.1	2.1	1.1
Pavlov. Cond. magazine entry latency	0.7	0.8	1.8	1.2	0.6	1.4	-1.3	-0.9	0.2	-0.3	-0.3
Pavlov. Cond. change in total contacts	1.8	2.5	5.0	1.6	1.8	1.7	-1.8	-1.8	0.4	-2.2	-0.1
Pavlov. Cond. index score	1.9	2.5	3.8	1.9	1.7	1.9	-1.9	-1.6	0.3	-1.5	-1.0
Pavlov. Cond. latency score	1.5	1.9	3.2	1.7	1.4	1.8	-1.8	-1.4	0.3	-1.0	-1.0
Pavlov. Cond. lever contacts	1.7	2.3	3.4	1.7	1.8	1.7	-1.7	-1.7	-0.2	-1.7	-0.9
Pavlov. Cond. magazine entry number	2.3	2.8	5.2	-2.2	-1.5	-2.3	2.3	1.9	0.6	0.7	0.8
Pavlov. Cond. intertrial magazine entries	2.3	3.0	6.0	-2.4	-1.7	-2.3	2.3	1.4	0.3	0.2	1.5
Pavlov. Cond. lever-magazine prob. diff.	2.2	2.8	4.1	2.0	1.8	2.0	-2.0	-1.8	0.3	-1.7	-0.8
Pavlov. Cond. response bias	1.9	2.6	3.7	1.9	1.8	1.9	-1.9	-1.8	-0.4	-1.4	-1.0
Time in closed arm before self-admin	2.2	2.5	4.2	1.7	1.9	1.7	-1.7	-2.1	-0.4	-1.6	-0.9
Time in closed arm after self-admin	3.4	3.5	5.9	2.1	2.2	2.2	-2.2	-2.4	-0.3	-1.6	-0.6
Time in open arm before self-admin	0.9	1.0	2.6	-0.9	-1.3	-0.8	0.8	1.2	0.1	1.6	0.3
Time in open arm after self-admin	0.4	0.5	0.9	-0.9	-0.7	-0.7	0.8	0.9	0.0	0.3	-0.4
Bone: periosteal estimation	0.1	0.2	0.4	0.5	0.5	0.4	-0.4	0.0	0.7	-0.5	-0.0
Bone: periosteal perimeter	0.3	0.6	1.3	0.7	0.9	0.5	-0.5	-0.1	1.1	-0.9	-0.8
Bone: post-yield work	0.8	1.0	2.2	1.0	1.4	1.0	-1.0	-1.0	0.2	-1.5	0.3
Progressive ratio test 1 active lever presses	1.3	1.4	2.5	-1.0	-1.4	-1.2	1.3	1.1	-0.7	1.6	0.8
Progressive ratio test 1 breakpoint	1.3	1.4	3.2	-1.0	-1.4	-1.1	1.2	0.9	-0.9	1.8	0.8
Progressive ratio test 1 inactive lever presses	0.3	0.3	0.9	-0.6	-0.1	-0.6	0.6	0.2	-1.0	0.0	0.5
Progressive ratio test 2 active lever presses	1.6	1.8	3.1	-1.5	-1.2	-1.7	1.8	1.3	1.0	-0.3	1.3
Progressive ratio test 2 breakpoint	1.5	1.7	2.9	-1.4	-1.0	-1.6	1.7	1.2	1.2	-0.6	1.4
Progressive ratio test 2 inactive lever presses	0.4	0.5	1.2	-0.6	-0.1	-0.8	0.8	0.0	0.4	-1.1	1.0
Incentive Sensitization - Responses	1.6	1.6	3.6	-1.1	-0.4	-1.4	1.4	0.9	1.9	-1.6	0.8
Incentive Sensitization - Breakpoint	1.6	1.6	3.9	-1.1	-0.4	-1.4	1.4	0.9	2.0	-1.6	0.7
Sum of active levers in priming session hrs 5-6	1.8	1.8	4.9	-1.0	-1.9	-1.1	0.9	1.6	0.1	2.2	0.6
Progressive ratio	0.9	1.0	2.6	-0.8	-0.8	-0.8	0.7	0.8	1.4	0.6	1.6
Food seeking constrained by brief footshock	0.3	0.3	1.1	-0.3	-0.6	-0.3	0.3	0.9	0.1	1.0	-0.5
Seeking ratio, punishment vs. effort	0.7	0.8	3.3	0.3	-0.0	0.3	-0.2	0.0	-1.8	0.7	-1.5
Retroperitoneal fat weight	0.1	0.3	1.5	0.3	0.8	0.2	-0.2	-0.5	-0.0	-1.2	-0.5
Reaction time number correct	0.4	0.6	1.3	1.1	1.1	0.7	-0.7	-0.9	-0.8	0.3	-0.2
Reaction time mean minus median	0.2	0.2	1.1	-0.3	-0.5	-0.2	0.2	-0.4	0.2	-0.4	1.1
Reaction time mean minus median AUC	0.5	0.7	2.3	-0.6	-1.1	-0.9	0.9	0.2	0.3	0.2	1.5
Reaction time num false alarms	0.7	0.9	2.2	-1.5	-1.0	-0.8	0.9	1.2	1.0	-0.3	-0.5
Reaction time num false alarms AUC	0.5	0.7	2.0	-1.4	-0.9	-0.7	0.8	1.0	0.9	-0.4	-0.4
Reaction time trials correct on left	0.4	0.6	1.3	1.1	1.1	0.7	-0.7	-0.9	-0.8	0.3	-0.2
Reaction time trials on left	0.4	0.6	1.2	1.1	1.1	0.6	-0.7	-0.9	-0.8	0.3	-0.1
Reaction time mean	0.3	0.4	1.3	0.1	0.0	0.2	-0.3	-0.7	0.0	-1.1	1.1
Reaction time mean AUC	0.3	0.4	1.6	-0.1	-0.0	0.1	-0.1	-0.6	-0.0	-1.3	1.0
Median of all reaction times	0.2	0.3	1.0	0.1	0.1	0.2	-0.3	-0.6	-0.1	-1.0	1.0
Reaction time omissions	0.7	0.9	1.6	-1.2	-0.7	-0.9	0.9	0.7	1.1	-0.8	1.3
Reaction time false alarm rate	0.9	1.3	3.2	-1.8	-1.3	-0.9	1.0	1.3	1.2	-0.6	-0.3
Reaction time premature initiation rate	0.3	0.4	0.7	-0.5	-0.7	-0.4	0.4	0.9	0.8	0.6	-0.7
Reaction time premature initiations	0.1	0.2	0.6	0.2	-0.1	0.0	-0.1	0.3	0.5	0.7	-0.7
Std. dev. reaction times	0.2	0.3	1.1	-0.1	-0.2	0.2	-0.3	-0.8	-0.5	-0.7	1.0
Reaction time trials completed	0.4	0.6	1.2	1.1	1.1	0.6	-0.7	-0.9	-0.8	0.3	-0.1
Reaction time trials AUC	0.4	0.6	1.1	1.1	1.0	0.6	-0.7	-0.8	-0.8	0.4	-0.1
Run reversals in cocaine runway, females	0.2	0.2	0.6	0.3	0.5	0.7	-0.7	-0.2	-0.2	-0.8	-0.1
Run reversals in cocaine runway, males	0.1	0.1	0.2	-0.2	0.1	-0.0	0.0	0.4	0.3	-0.1	-0.4
Latency to leave start box in cocaine runway	3.1	3.4	6.5	2.6	2.2	2.3	-2.2	-2.2	0.6	-0.6	-0.1
Latency to leave start box in cocaine runway, F	4.4	4.8	8.9	3.0	2.5	2.7	-2.8	-2.6	-0.7	0.2	-0.8
Latency to leave start box in cocaine runway, M	1.3	1.3	5.9	0.1	0.4	-0.0	0.2	0.2	2.4	-1.8	0.9
Std. dev. time between licks in bursts	1.1	1.3	4.4	0.7	1.4	0.8	-0.8	-1.4	-0.4	-2.1	-0.5
Total sessions with >9 infusions	0.2	0.3	1.0	0.1	-0.3	0.2	-0.1	-0.4	-1.0	0.6	0.7
Short access day 1 total inactive lever presses	0.2	0.2	0.9	-0.4	-0.3	-0.2	0.3	0.2	-0.1	0.5	0.9
Short access day 10 total inactive lever presses	0.5	0.6	3.4	-0.3	0.2	-0.0	0.1	0.1	1.9	-0.9	-0.1
Short access day 1 total infusions	0.6	0.6	3.9	0.6	0.3	0.4	-0.4	-0.6	-2.0	0.2	0.2
Short access day 10 total infusions	0.3	0.4	1.7	0.4	0.0	0.4	-0.3	-0.4	-1.3	0.7	-0.6
Short access total infusions	0.6	0.7	2.6	0.9	0.5	0.7	-0.7	-0.9	-1.6	0.3	-0.3
Short access day 1 locomotion	0.1	0.1	0.4	0.6	0.3	0.3	-0.3	-0.5	-0.4	-0.2	-0.3
Short access day 10 total locomotion	0.5	0.6	1.0	-0.5	-0.9	-0.5	0.5	0.8	-1.0	1.0	-0.8
Short access total locomotion	0.6	0.6	2.3	0.5	0.0	0.4	-0.4	-0.5	-1.5	0.4	-1.1
One hour access (0.3 mA shock)	0.7	0.8	1.9	-0.9	-0.9	-0.9	1.0	0.6	1.4	-0.0	1.1
Compulsive drug intake	2.8	2.8	4.6	-1.7	-2.1	-1.8	1.8	1.8	0.1	1.9	1.3
One hour access (shock baseline)	0.5	0.6	2.4	-0.1	0.5	0.0	-0.0	-0.1	1.6	-1.4	0.2
Social response proportion	1.6	1.7	2.7	-1.2	-1.4	-1.5	1.5	1.2	-0.2	1.1	1.6
Social responses	1.1	1.4	2.3	-1.3	-0.8	-1.4	1.4	1.5	1.3	0.2	1.0
Social time	1.8	2.3	4.9	-2.2	-1.2	-1.9	2.0	1.8	1.1	-0.2	-0.2
Soleus weight	1.1	3.2	4.7	2.1	2.2	1.9	-1.9	-1.9	-1.0	-1.2	-1.7
Bone: stiffness	0.1	0.2	0.9	0.4	0.1	0.2	-0.2	-0.3	-0.9	0.4	0.2
Tibialis anterior weight	0.5	1.6	6.1	-0.8	-0.5	-1.3	1.3	1.3	2.5	-0.6	0.8
Time to tail flick, vehicle, before self-admin	0.5	0.5	0.9	-0.8	-0.7	-0.8	0.9	0.8	-0.4	0.3	0.9
Time to tail flick, vehicle, after self-admin	0.5	0.5	1.0	1.0	0.9	1.0	-0.9	-0.6	-0.4	-0.3	-0.5
Time to tail flick, test, before self-admin	1.6	1.6	2.4	1.5	1.4	1.6	-1.5	-1.4	-0.9	-0.4	-0.9
Time to tail flick, test, after self-admin	1.2	1.2	2.5	1.2	0.9	1.1	-1.0	-1.3	-1.6	0.4	-0.9
Delta time to tail flick, vehicle, before/after SA	1.2	1.2	1.9	1.3	1.4	1.3	-1.3	-1.1	-0.4	-0.7	-0.9
Delta time to tail flick, test, before/after SA	0.6	0.5	1.6	-0.6	-0.9	-0.7	0.6	0.5	-0.6	1.3	0.4
Tibia length	1.2	3.5	5.2	2.1	1.7	2.1	-2.1	-2.1	-2.3	-0.4	-1.2
Ambulatory time before self-admin	3.8	3.9	5.2	-2.2	-1.7	-2.2	2.1	2.1	2.3	-0.2	2.0
Ambulatory time after self-admin	0.7	0.8	1.8	-0.8	-0.4	-0.8	0.7	1.2	1.3	0.3	-1.0
Bone: tissue strength	1.9	1.8	3.0	1.7	1.1	1.5	-1.5	-1.5	-1.5	0.2	-1.1
Total heroin consumption	1.0	1.2	2.8	-0.8	-1.0	-0.7	0.7	1.7	0.7	1.4	1.3
Bone: trabecular number	0.5	0.8	2.2	-0.2	-0.7	-0.4	0.4	1.3	1.0	1.5	-0.6
Bone: trabecular spacing	0.9	1.1	3.6	-1.2	-0.0	-1.0	1.0	0.0	0.9	-1.9	1.1
Bone: trabecular thickness	4.8	5.7	9.8	3.1	2.7	3.1	-3.1	-2.4	-1.2	-0.7	-1.5
Bone: trabecular tissue density	0.9	1.3	2.8	1.0	0.8	1.2	-1.2	-1.7	-1.5	-0.7	-0.2
Water consumed over 24 hours	0.0	0.1	0.2	-0.2	-0.2	-0.3	0.3	0.1	0.4	-0.0	-0.1
Number of responses in last shaping day	1.8	1.9	3.6	1.9	1.7	1.4	-1.4	-1.5	0.3	-1.4	-0.3