Hub : Genes

Kansl2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain isoform ratio NM_001004244.3 0.05 0.04 1.1e-05 0.04 0.04 0.04 0.04 1.0e-04 7.8e-05 9.5e-05 6.2e-05
2 PL isoform ratio XM_008765693.3 0.04 0.03 9.8e-06 0.04 0.04 0.04 0.04 1.6e-05 9.8e-06 4.4e-05 2.8e-05
3 Adipose intron excision ratio chr7_129679805_129682769 0.02 0.02 3.8e-03 0.02 0.02 0.01 0.02 3.6e-03 3.0e-03 1.3e-02 4.9e-03
4 Brain intron excision ratio chr7_129685147_129685692 0.04 0.03 4.6e-04 0.02 0.03 0.02 0.02 3.1e-03 4.7e-04 2.8e-03 5.9e-03
5 Brain intron excision ratio chr7_129685147_129685358 0.02 0.02 2.8e-03 0.02 0.02 0.01 0.02 3.6e-03 6.9e-03 1.5e-02 1.1e-02
6 Brain isoform ratio NM_001421308.1 0.06 0.04 3.0e-08 0.08 0.08 0.08 0.09 9.6e-08 4.0e-08 5.8e-08 2.7e-08
7 PL intron excision ratio chr7_129685147_129685358 0.04 0.03 3.5e-06 0.05 0.04 0.03 0.04 8.0e-06 1.5e-05 9.9e-05 3.1e-05
8 PL mRNA stability Kansl2 0.05 0.03 9.3e-07 0.04 0.05 0.04 0.04 9.5e-06 3.1e-06 3.5e-05 2.4e-05
9 IL gene expression Kansl2 0.14 0.11 2.7e-03 0.1 0.1 0.08 0.1 2.0e-03 2.7e-03 5.9e-03 2.1e-03
10 NAcc mRNA stability Kansl2 0.03 0.02 3.6e-04 0.02 0.03 0.02 0.02 1.5e-03 5.2e-04 1.7e-03 2.2e-03
11 Brain gene expression Kansl2 0.11 0.06 2.4e-15 0.19 0.16 0.17 0.18 3.0e-17 3.6e-15 4.3e-16 8.0e-17
12 OFC mRNA stability Kansl2 0.11 0.08 5.5e-03 0.09 0.06 0.07 0.07 4.2e-03 1.3e-02 9.4e-03 1.2e-02
13 Adipose gene expression Kansl2 0.12 0.08 2.4e-14 0.12 0.11 0.12 0.12 2.0e-13 1.3e-12 2.4e-13 8.4e-13
14 Adipose mRNA stability Kansl2 0.05 0.04 6.8e-06 0.03 0.03 0.03 0.03 1.5e-04 2.1e-04 3.8e-04 4.4e-04
15 PL intron excision ratio chr7_129685147_129685618 0.04 0.03 3.7e-06 0.04 0.04 0.02 0.03 2.4e-05 4.3e-05 5.7e-03 9.9e-05
16 BLA gene expression Kansl2 0.07 0.06 1.1e-03 0.06 0.06 0.05 0.06 3.0e-04 6.4e-04 7.0e-04 5.1e-04
17 NAcc gene expression Kansl2 0.04 0.03 8.3e-06 0.05 0.04 0.04 0.05 1.9e-06 1.2e-05 3.8e-05 4.6e-06
18 OFC gene expression Kansl2 0.27 0.15 5.5e-06 0.15 0.16 0.1 0.13 2.3e-04 1.2e-04 2.5e-03 6.5e-04
19 Brain mRNA stability Kansl2 0.09 0.06 3.0e-11 0.13 0.11 0.12 0.12 7.9e-12 9.7e-11 2.2e-11 2.5e-11
20 PL isoform ratio NM_001421308.1 0.09 0.07 2.8e-11 0.11 0.08 0.1 0.1 3.6e-12 9.1e-09 6.8e-11 2.8e-11
21 BLA mRNA stability Kansl2 0.08 0.09 5.1e-03 0.04 0.04 0.04 0.04 2.0e-03 3.0e-03 2.3e-03 2.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
Bone: apparent density9.816.320.2-4.5-4.4-4.3-4.4-4.34.2-4.2-4.24.1-4.1-4.14.1-4.04.14.14.0-4.13.63.2-3.23.1
Area under the delay curve1.21.31.8-1.1-1.2-1.2-1.2-1.01.1-1.0-1.21.3-1.1-1.31.2-1.21.31.11.2-1.10.80.9-0.90.7
BMI with tail4.614.817.7-3.9-4.1-4.1-4.1-3.54.0-3.6-4.04.0-4.0-4.23.8-4.14.23.93.9-3.83.43.4-3.43.1
BMI without tail0.10.10.70.1-0.1-0.3-0.20.40.10.3-0.30.6-0.3-0.60.4-0.40.60.30.8-0.30.1-0.10.10.1
Body weight6.728.133.4-5.2-5.3-5.4-5.4-4.85.4-4.9-5.55.6-5.4-5.85.4-5.55.75.35.7-5.25.04.9-4.94.7
Weight adjusted by age2.52.94.2-1.3-1.4-1.6-1.5-1.51.6-1.5-1.71.8-1.7-1.81.8-1.71.81.72.0-1.81.91.7-1.72.0
Bone surface11.620.323.6-4.9-4.8-4.7-4.8-4.84.7-4.7-4.74.6-4.6-4.54.6-4.54.54.54.5-4.64.23.8-3.83.7
Bone volume8.614.617.7-4.2-4.1-4.0-4.1-4.14.0-4.1-4.03.9-3.9-3.93.9-3.83.83.83.7-3.93.53.1-3.13.1
Breakpoint value in progressive ratio session0.20.20.4-0.5-0.4-0.4-0.4-0.50.5-0.5-0.40.3-0.4-0.30.4-0.50.40.50.4-0.50.40.6-0.60.5
Number of licking bursts0.20.20.70.90.70.60.70.8-0.40.80.4-0.20.30.3-0.10.2-0.3-0.3-0.30.30.10.5-0.50.3
Context. condit. distance diff. score0.30.40.6-0.5-0.5-0.6-0.5-0.20.6-0.4-0.60.7-0.6-0.60.7-0.60.60.60.7-0.70.60.6-0.60.8
Locomotion velocity, session 11.01.11.51.21.21.21.21.0-1.11.01.1-1.01.11.1-0.91.1-1.1-1.2-1.21.1-0.9-0.80.8-0.8
Locomotion distance, session 13.34.26.31.81.81.91.81.8-2.01.82.0-1.82.02.0-1.92.1-2.0-2.0-2.32.0-2.3-2.52.5-2.3
Locomotion velocity, session 20.30.30.90.40.40.50.50.4-0.60.40.6-0.40.60.7-0.30.6-0.7-0.7-1.00.6-0.6-0.70.7-0.7
Locomotion distance, session 22.63.75.41.71.71.81.71.7-1.91.61.9-1.81.91.9-1.81.9-1.9-2.0-2.21.9-2.1-2.32.3-2.2
Locomotion velocity, session 33.84.45.42.22.02.12.02.0-2.22.02.1-2.02.12.1-1.92.2-2.1-2.1-2.12.1-2.2-2.32.3-2.2
Locomotion distance, session 35.15.56.52.32.32.32.32.1-2.42.12.4-2.32.42.4-2.32.4-2.3-2.3-2.32.3-2.5-2.62.6-2.4
Stereotopy head waving bouts, day 31.11.32.0-1.0-1.1-1.1-1.1-1.21.2-1.3-1.10.9-1.2-1.10.9-1.11.11.10.7-1.21.41.3-1.31.4
Stereotopy head waving duration, day 30.40.50.9-0.6-0.7-0.7-0.7-0.80.7-0.9-0.70.5-0.7-0.60.5-0.70.60.60.2-0.70.90.8-0.80.8
Locomotion velocity, session 70.10.10.30.40.40.40.40.4-0.40.40.3-0.30.30.2-0.20.5-0.2-0.20.00.3-0.3-0.40.4-0.2
Locomotion distance, session 71.31.62.11.51.41.31.41.4-1.31.41.3-1.21.31.1-1.21.4-1.1-1.2-0.61.3-1.2-1.21.2-1.1
Stereotopy head waving bouts, day 71.01.22.2-0.9-0.9-1.0-0.9-1.11.1-1.2-1.00.8-1.1-1.00.9-1.00.91.00.9-1.11.41.3-1.31.5
Stereotopy head waving duration, day 71.21.52.6-1.0-1.1-1.1-1.0-1.31.2-1.3-1.21.1-1.3-1.21.1-1.21.11.11.0-1.21.61.4-1.41.6
Locomotion velocity, session 80.00.00.0-0.1-0.1-0.1-0.10.10.10.0-0.10.2-0.1-0.00.2-0.00.10.1-0.1-0.10.1-0.00.00.1
Locomotion distance, session 81.32.03.31.21.21.31.21.4-1.31.31.3-1.31.41.4-1.21.3-1.4-1.4-1.41.3-1.6-1.81.8-1.6
Degree of sensitization distance0.70.71.3-0.7-0.7-0.7-0.7-0.60.8-0.6-0.80.8-0.8-0.90.7-0.70.90.81.1-0.80.90.9-0.90.9
Degree of sensitization stereotypy0.30.31.0-0.4-0.3-0.4-0.3-0.50.5-0.5-0.40.5-0.5-0.40.5-0.50.40.40.5-0.50.90.9-0.91.0
Conditioned locomotion0.10.10.60.00.1-0.00.1-0.30.2-0.3-0.1-0.0-0.2-0.1-0.1-0.20.10.10.2-0.10.60.6-0.60.8
Cocaine response after cond. corrected0.10.10.8-0.3-0.3-0.2-0.30.0-0.10.2-0.0-0.00.1-0.0-0.10.00.1-0.0-0.20.1-0.7-0.70.7-0.9
Cocaine response after cond. not corrected0.80.92.20.40.50.70.50.7-0.90.80.8-0.90.90.9-1.00.8-0.9-0.9-1.10.9-1.3-1.21.2-1.5
Cocaine response before conditioning4.04.86.42.22.32.32.41.9-2.21.92.3-2.42.22.5-2.42.2-2.5-2.3-2.42.3-1.8-1.51.5-1.8
Saline control response0.10.10.3-0.4-0.3-0.2-0.3-0.50.3-0.5-0.20.0-0.2-0.10.1-0.3-0.00.10.3-0.20.30.2-0.20.2
Bone: connectivity density6.910.814.4-3.8-3.7-3.5-3.7-3.73.4-3.5-3.43.3-3.3-3.33.3-3.33.33.33.2-3.42.82.5-2.52.4
Bone: cortical apparent density0.30.40.60.70.70.70.80.5-0.70.70.7-0.70.70.7-0.70.6-0.7-0.7-0.60.7-0.4-0.40.4-0.4
Bone: cortical area10.415.617.3-4.0-4.0-4.0-4.0-4.04.0-3.9-4.04.2-4.0-4.14.1-4.04.04.04.0-4.03.83.6-3.63.6
Bone: cortical porosity1.21.31.81.21.21.21.30.9-1.20.71.2-1.21.21.3-1.31.2-1.3-1.3-1.31.3-0.9-0.80.8-0.9
Bone: cortical porosity1.71.82.61.41.41.41.51.1-1.40.81.5-1.51.41.5-1.61.4-1.5-1.5-1.51.5-1.1-1.01.0-1.0
Bone: cortical thickness4.27.08.2-2.6-2.7-2.7-2.7-2.52.7-2.4-2.82.9-2.7-2.82.8-2.72.82.82.6-2.82.42.2-2.22.3
Bone: cortical thickness0.30.30.7-0.6-0.6-0.6-0.6-0.40.6-0.3-0.60.7-0.6-0.70.7-0.60.60.60.8-0.60.40.5-0.50.4
Bone: cortical tissue density0.40.60.80.80.90.80.90.6-0.80.80.8-0.90.80.8-0.90.8-0.8-0.8-0.70.8-0.5-0.50.5-0.5
Condit. Reinf. active minus inactive responses0.10.10.6-0.00.10.20.10.1-0.30.20.2-0.20.30.3-0.20.3-0.2-0.2-0.60.2-0.5-0.80.8-0.6
Condit. Reinf. active-inactive response ratio0.20.20.6-0.8-0.6-0.5-0.6-0.70.4-0.5-0.40.4-0.4-0.40.3-0.30.40.40.1-0.50.1-0.10.1-0.0
Condit. Reinf. active responses0.60.71.50.60.70.70.70.8-0.70.90.8-0.90.80.8-0.80.8-0.8-0.7-1.20.8-1.0-1.11.1-1.0
Condit. Reinf. inactive responses2.63.13.91.91.81.81.82.0-1.71.91.8-1.91.81.8-1.81.7-1.8-1.8-1.81.8-1.6-1.31.3-1.5
Incentive salience index mean0.10.10.1-0.4-0.4-0.3-0.4-0.10.3-0.1-0.30.3-0.3-0.30.4-0.20.30.30.0-0.30.1-0.10.10.0
Condit. Reinf. lever presses0.30.40.6-0.6-0.6-0.6-0.7-0.30.6-0.4-0.70.8-0.6-0.80.8-0.70.80.70.4-0.70.50.4-0.40.5
Condit. Reinf. active minus inactive responses0.00.00.10.30.30.20.30.1-0.20.10.2-0.20.20.2-0.00.3-0.2-0.30.10.3-0.10.0-0.0-0.1
Condit. Reinf. active-inactive response ratio0.30.30.40.60.60.60.60.5-0.60.60.6-0.60.60.6-0.40.6-0.5-0.6-0.50.6-0.6-0.60.6-0.6
Condit. Reinf. active responses0.20.30.50.70.60.60.60.5-0.60.40.6-0.60.60.6-0.40.6-0.6-0.6-0.20.7-0.4-0.20.2-0.4
Condit. Reinf. inactive responses0.70.81.21.11.11.01.10.9-0.90.81.0-1.00.91.1-1.01.0-1.0-1.0-0.71.0-0.6-0.40.4-0.6
Condit. Reinf. lever presses0.00.00.00.00.00.10.10.0-0.1-0.00.1-0.10.10.2-0.10.1-0.2-0.00.20.1-0.10.2-0.2-0.2
Condit. Reinf. lever reinforcers received0.50.81.01.01.00.91.00.8-1.00.81.0-0.90.91.0-0.81.0-0.9-0.9-0.61.0-0.8-0.60.6-0.8
Conditioned reinforcement - actives1.41.41.91.41.21.31.31.2-1.31.11.2-1.21.21.2-1.31.2-1.3-1.1-1.11.2-1.1-1.01.0-1.0
Conditioned reinforcement - inactives1.61.82.21.51.31.31.31.4-1.41.31.3-1.21.31.2-1.31.2-1.2-1.3-1.31.3-1.5-1.41.4-1.3
Conditioned locomotion0.30.40.90.90.80.70.80.6-0.70.50.7-0.60.60.6-0.60.6-0.6-0.7-0.20.6-0.3-0.30.3-0.2
Patch foraging indifference point 0 sec1.93.13.71.91.91.81.81.9-1.81.91.8-1.51.81.8-1.41.9-1.8-1.9-1.21.8-1.8-1.61.6-1.7
Patch foraging indifference point AUC0.20.20.40.60.60.50.60.3-0.50.30.5-0.40.50.5-0.50.3-0.6-0.6-0.20.5-0.2-0.60.6-0.4
Delay disc. indifference point, 0s delay1.31.42.0-1.0-1.1-1.2-1.1-1.31.1-1.3-1.21.3-1.2-1.41.1-1.21.41.11.4-1.01.30.8-0.81.2
Delay disc. indifference point, 16s delay1.31.42.2-1.0-1.0-1.1-1.1-1.01.1-1.0-1.21.4-1.1-1.41.4-1.11.41.11.5-1.21.11.1-1.11.0
Delay disc. indifference point, 2s delay1.21.31.5-1.2-1.2-1.2-1.2-1.11.2-1.2-1.21.1-1.2-1.10.9-1.21.11.21.1-1.11.21.0-1.01.2
Delay disc. indifference point, 24s delay1.61.52.1-1.1-1.2-1.2-1.2-1.11.2-1.2-1.21.3-1.2-1.31.5-1.41.31.21.4-1.21.21.2-1.21.1
Delay disc. indifference point, 4s delay0.30.30.6-0.7-0.7-0.7-0.7-0.40.5-0.4-0.60.6-0.5-0.70.7-0.50.70.60.4-0.50.10.4-0.40.0
Delay disc. indifference point, 8s delay3.13.24.0-1.8-1.9-1.9-1.9-1.71.8-1.8-1.92.0-1.8-2.01.9-1.92.01.81.7-1.81.41.6-1.61.3
Indifference point function ln k3.65.05.9-2.3-2.2-2.3-2.3-2.32.3-2.3-2.32.3-2.2-2.22.4-2.12.32.12.1-2.22.22.2-2.21.9
Indifference point function log k3.65.05.9-2.3-2.2-2.3-2.3-2.32.3-2.3-2.32.3-2.2-2.22.4-2.12.32.12.1-2.22.22.2-2.21.9
Patch foraging total patch changes 0 sec1.93.03.61.91.91.81.81.9-1.81.91.8-1.51.81.8-1.41.9-1.8-1.8-1.11.8-1.7-1.51.5-1.6
Patch foraging total patch changes 12 sec1.62.12.91.71.61.61.61.6-1.61.61.5-1.31.51.5-1.31.4-1.6-1.5-1.01.3-1.2-1.31.3-1.0
Patch foraging total patch changes 18 sec3.95.06.52.52.52.42.52.2-2.42.22.4-2.12.32.2-2.02.3-2.3-2.5-1.42.4-1.9-2.12.1-2.0
Patch foraging total patch changes 24 sec1.61.93.01.71.71.61.71.5-1.51.61.5-1.11.41.4-1.11.6-1.4-1.4-0.71.4-1.0-1.11.1-0.9
Patch foraging total patch changes 6 sec2.33.44.22.01.91.91.91.8-1.91.81.9-1.81.92.0-1.71.8-2.0-1.9-1.51.9-1.8-1.81.8-1.7
Patch foraging time to switch 0 sec2.43.75.21.91.92.02.02.1-1.92.02.0-2.32.02.1-2.31.9-2.1-1.8-2.11.8-1.8-1.41.4-1.5
Patch foraging water rate 0 sec3.25.27.2-2.1-2.2-2.3-2.3-2.32.3-2.2-2.42.7-2.3-2.52.6-2.22.42.12.6-2.22.31.7-1.72.1
Patch foraging water rate 12 sec3.55.46.3-2.3-2.3-2.4-2.3-2.52.4-2.5-2.42.4-2.4-2.42.4-2.22.42.22.2-2.22.42.1-2.12.2
Patch foraging water rate 18 sec0.40.50.8-0.6-0.6-0.7-0.6-0.60.7-0.6-0.70.8-0.7-0.80.8-0.60.70.80.9-0.70.60.6-0.60.8
Patch foraging water rate 24 sec3.04.25.7-2.0-1.9-2.0-1.9-2.12.1-2.0-2.02.0-2.1-2.02.1-2.01.91.81.9-2.12.32.0-2.02.4
Patch foraging water rate 6 sec3.85.56.4-2.3-2.3-2.4-2.3-2.42.4-2.4-2.42.5-2.4-2.42.4-2.22.52.42.3-2.32.42.2-2.22.3
Seeking ratio, delayed vs. immediate footshock0.40.40.8-0.9-0.9-0.8-0.9-0.60.7-0.6-0.70.6-0.6-0.70.2-0.70.70.70.1-0.70.20.5-0.5-0.1
Distance traveled before self-admin1.01.11.51.21.21.21.21.2-1.01.11.1-1.01.01.0-1.11.0-1.1-1.1-0.81.1-0.8-0.90.9-0.7
Distance traveled after self-admin0.20.20.50.30.40.40.40.5-0.30.40.4-0.30.40.3-0.40.4-0.4-0.6-0.40.4-0.5-0.50.5-0.7
Extensor digitorum longus weight4.818.823.8-3.9-4.1-4.2-4.1-3.84.4-3.7-4.44.6-4.4-4.64.6-4.44.44.54.9-4.54.34.3-4.34.4
Bone: elastic displacement4.75.46.42.32.42.42.42.3-2.42.42.4-2.12.42.4-2.22.5-2.4-2.4-2.32.4-2.2-2.12.1-2.1
Bone: elastic work0.00.00.1-0.00.20.20.20.0-0.20.00.2-0.00.20.2-0.10.4-0.2-0.2-0.10.2-0.1-0.00.0-0.1
Bone: endosteal estimation7.215.717.8-4.0-3.9-3.9-3.9-4.24.0-4.2-3.93.9-4.0-3.94.0-3.83.83.84.0-3.94.14.0-4.03.8
Bone: endosteal perimeter7.014.515.3-3.7-3.7-3.8-3.7-3.83.8-3.8-3.83.9-3.8-3.83.9-3.83.83.83.9-3.83.83.9-3.93.6
Epididymis fat weight0.20.51.1-0.7-0.7-0.7-0.7-0.40.6-0.5-0.71.1-0.6-1.11.0-0.61.00.60.9-0.40.40.1-0.10.2
Delta time in closed arm before/after self-admin0.20.20.6-0.8-0.7-0.6-0.7-0.60.4-0.6-0.50.4-0.4-0.40.3-0.40.50.4-0.1-0.2-0.00.4-0.4-0.1
Delta time in open arm before/after self-admin4.14.04.62.12.12.12.12.1-1.92.12.0-2.02.02.0-2.02.0-2.1-1.9-1.81.9-1.7-2.02.0-1.6
Diff in mean of infusions in LGA sessions1.31.52.6-1.4-1.4-1.3-1.4-1.31.3-1.2-1.31.1-1.3-1.11.1-1.21.11.60.9-1.21.01.1-1.11.0
Delay discount exponential model param1.01.11.51.11.21.11.20.9-1.00.91.1-1.21.01.2-1.11.1-1.2-1.1-1.11.0-0.7-0.90.9-0.6
Extinction: sum of active levers before priming0.40.40.7-0.6-0.5-0.6-0.5-0.60.6-0.7-0.60.6-0.6-0.60.5-0.60.60.60.8-0.60.70.3-0.30.7
Active lever presses in extinction session 60.50.50.7-0.8-0.8-0.7-0.7-0.70.7-0.7-0.70.7-0.6-0.60.7-0.70.60.60.5-0.70.50.7-0.70.5
Bone: final force10.016.118.2-4.3-4.2-4.2-4.2-4.14.1-4.1-4.14.2-4.1-4.14.2-4.04.14.13.9-4.13.73.4-3.43.4
Bone: final moment10.116.419.4-4.4-4.3-4.2-4.3-4.34.2-4.2-4.24.2-4.1-4.14.3-4.04.14.13.9-4.13.73.4-3.43.3
Food consumed during 24 hour testing period1.51.92.9-1.7-1.7-1.5-1.6-1.61.5-1.6-1.41.3-1.4-1.31.3-1.41.21.31.2-1.51.00.9-0.90.8
Glucose0.10.20.8-0.3-0.3-0.4-0.3-0.10.4-0.1-0.50.4-0.5-0.50.5-0.50.60.50.9-0.50.50.4-0.40.7
Heart weight0.00.10.2-0.5-0.3-0.2-0.3-0.20.3-0.2-0.1-0.0-0.10.0-0.2-0.20.00.2-0.4-0.2-0.10.3-0.3-0.1
Delay discount hyperbolic model param1.01.01.41.01.11.11.10.9-1.00.91.1-1.21.01.2-1.11.0-1.2-1.0-1.01.0-0.7-0.80.8-0.6
Intermittent access intake day 1-15 change1.11.11.61.01.01.01.01.2-1.11.11.0-1.01.11.0-1.11.0-1.0-0.8-1.21.0-1.3-0.80.8-1.2
Intermittent access intake escalation0.70.71.30.80.80.80.71.0-0.90.90.8-0.80.90.8-0.90.8-0.8-0.6-1.10.9-1.1-0.70.7-1.1
Intermittent access intake escalation 21.21.11.81.11.01.01.01.3-1.11.21.0-1.01.11.0-1.11.1-1.0-0.8-1.21.1-1.3-0.90.9-1.3
Intermitt. access day 1 inactive lever presses3.33.64.82.12.22.12.21.9-1.91.82.0-1.91.92.0-1.82.0-2.0-2.0-1.42.0-1.4-1.71.7-1.3
Intermitt. access day 15 inactive lever presses1.21.31.81.31.31.21.31.3-1.21.21.2-1.01.21.0-1.01.1-1.0-1.3-0.71.2-1.0-1.21.2-0.9
Intermitt. access escalation Index0.30.20.60.40.50.50.60.7-0.40.80.5-0.50.50.6-0.40.5-0.4-0.5-0.40.4-0.3-0.20.2-0.2
Intermittent access day 1 total infusions1.11.31.61.21.11.11.11.1-1.21.11.2-1.21.21.2-1.21.1-1.2-1.2-1.31.1-1.2-1.11.1-1.1
Intermittent access day 15 total infusions2.22.43.01.71.61.61.61.7-1.61.61.6-1.51.61.6-1.61.6-1.5-1.4-1.61.5-1.7-1.31.3-1.5
Intermittent access terminal intake (last 3 days)2.42.73.11.71.71.71.61.7-1.71.71.6-1.51.71.6-1.61.7-1.6-1.6-1.61.7-1.7-1.51.5-1.6
Intermittent access total infusions2.22.52.91.71.61.61.61.7-1.61.61.6-1.51.61.6-1.61.6-1.5-1.6-1.51.5-1.6-1.41.4-1.5
Intermittent access day 1 locomotion0.90.91.51.21.21.11.21.0-1.01.01.0-0.91.00.9-0.91.1-0.9-1.1-0.61.0-0.6-0.80.8-0.5
Intermittent access day 15 total locomotion1.11.22.81.71.51.31.41.3-1.31.11.2-0.91.10.9-0.91.2-0.9-1.1-0.61.2-0.7-0.70.7-0.6
Intermittent access total locomotion2.83.25.72.42.22.02.21.9-2.01.91.9-1.71.81.6-1.61.9-1.7-1.9-1.11.9-1.3-1.41.4-1.1
Intermittent access standard deviation0.40.50.90.60.60.70.60.8-0.60.80.7-0.60.70.8-0.90.6-0.7-0.4-0.90.6-0.8-0.50.5-0.8
Left kidney weight0.41.02.1-1.4-1.4-1.2-1.4-1.01.1-1.1-1.11.0-1.0-1.00.7-1.01.11.20.4-1.00.40.6-0.60.2
Right kidney weight2.87.98.6-2.8-2.8-2.9-2.9-2.72.8-2.8-2.92.9-2.9-2.92.7-2.82.92.92.9-2.82.72.6-2.62.6
Cocaine induced anxiety1.21.41.9-1.0-1.1-1.1-1.0-1.11.2-1.2-1.11.0-1.2-1.01.2-1.21.01.21.2-1.21.31.3-1.31.4
Post-drug Anxiety4.75.26.1-2.3-2.3-2.3-2.2-2.32.4-2.4-2.32.1-2.3-2.12.1-2.52.12.22.2-2.42.42.3-2.32.4
Baseline Anxiety1.11.11.5-1.1-1.1-1.1-1.2-1.01.1-0.8-1.11.2-1.1-1.21.1-1.21.21.01.0-1.10.90.8-0.80.8
Tail length0.10.20.50.70.50.40.50.6-0.50.60.4-0.10.40.3-0.10.4-0.3-0.40.30.4-0.2-0.40.4-0.2
Length with tail2.07.39.6-2.7-2.7-2.7-2.7-2.62.8-2.6-2.72.9-2.7-2.92.8-2.72.82.63.1-2.62.62.5-2.52.4
Length without tail7.516.419.7-4.4-4.3-4.2-4.3-4.14.3-4.1-4.24.0-4.1-4.14.0-4.24.14.03.7-4.03.63.9-3.93.4
Times rat made contact with spout0.00.10.20.10.00.1-0.00.5-0.10.40.10.10.1-0.10.20.0-0.1-0.0-0.30.0-0.4-0.30.3-0.4
Lifetime Intake1.82.02.61.61.51.51.51.6-1.51.61.4-1.31.51.3-1.41.5-1.3-1.4-1.31.4-1.5-1.31.3-1.3
Liver weight, left2.03.33.8-1.8-1.8-1.8-1.8-1.71.8-1.7-1.91.8-1.8-1.91.8-1.91.92.02.0-1.91.71.6-1.61.7
Liver weight, right1.72.84.3-1.7-1.6-1.7-1.7-1.51.6-1.5-1.71.8-1.7-1.81.9-1.71.91.82.1-1.61.61.4-1.41.6
Locomotor activity0.81.22.11.41.31.21.31.2-1.21.21.2-1.01.11.1-1.01.2-1.1-0.9-1.11.0-1.0-1.01.0-0.8
Locomotor testing distance2.54.15.42.32.22.22.22.1-2.12.12.1-2.02.12.0-1.82.2-1.9-1.9-2.12.0-1.9-1.61.6-1.7
Locomotor testing rearing2.03.04.42.12.12.02.12.0-1.82.01.9-1.71.81.8-1.51.8-1.8-1.9-1.61.8-1.4-0.80.8-1.2
Locomotion in novel chamber0.60.71.1-0.7-0.8-0.8-0.8-0.80.8-0.8-0.91.0-0.9-0.80.8-0.90.90.80.8-0.71.00.7-0.71.0
Locomotion in novel chamber post-restriction0.10.10.7-0.1-0.1-0.3-0.2-0.10.2-0.2-0.30.8-0.3-0.60.5-0.10.70.10.8-0.10.30.1-0.10.2
Fecal boli incidents, locomotor time 11.71.84.81.01.01.00.91.6-1.41.61.1-1.01.31.0-1.01.4-1.0-1.0-1.61.1-2.0-1.71.7-2.2
Change in fecal boli incidents, locomotor task1.11.01.6-1.0-1.0-1.0-1.0-1.01.0-1.2-1.01.0-1.0-0.90.9-1.00.91.01.1-1.11.20.7-0.71.3
Time >=10cm from walls, locomotor time 10.30.30.7-0.6-0.6-0.6-0.7-0.30.4-0.4-0.60.7-0.5-0.80.6-0.40.80.60.4-0.50.20.3-0.30.0
Bouts of movement, locomotor time 10.10.10.3-0.3-0.2-0.3-0.3-0.00.0-0.0-0.30.5-0.2-0.60.30.10.60.30.1-0.2-0.1-0.20.2-0.2
Total resting periods, locomotor time 10.20.20.50.20.30.20.20.5-0.50.50.2-0.10.30.0-0.20.6-0.0-0.2-0.30.4-0.6-0.70.7-0.7
Rest time, locomotor task time 10.20.30.60.40.40.40.30.7-0.60.70.4-0.20.50.2-0.50.6-0.2-0.5-0.40.4-0.7-0.80.8-0.8
Distance moved, locomotor task time 10.10.10.20.10.10.10.1-0.20.0-0.10.2-0.40.10.4-0.4-0.1-0.4-0.1-0.20.10.20.4-0.40.1
Vertical activity count, locomotor time 11.31.41.9-1.3-1.4-1.3-1.4-1.31.3-1.3-1.21.1-1.2-1.01.0-1.31.01.30.9-1.10.91.3-1.30.8
Time >=10cm from walls, locomotor time 20.40.51.00.90.70.70.70.8-0.70.70.6-0.40.60.5-0.60.7-0.5-0.4-0.50.6-0.7-1.01.0-0.6
Bouts of movement, locomotor time 22.62.83.6-1.4-1.5-1.6-1.5-1.61.6-1.6-1.71.8-1.7-1.81.8-1.71.81.71.8-1.41.91.5-1.51.8
Total resting periods, locomotor time 22.93.14.0-1.6-1.6-1.7-1.6-1.71.7-1.7-1.81.9-1.8-1.81.9-1.81.81.81.9-1.62.01.6-1.61.9
Rest time, locomotor task time 20.10.10.3-0.4-0.3-0.3-0.30.10.20.1-0.40.6-0.3-0.50.5-0.30.50.40.3-0.30.10.2-0.20.0
Distance moved, locomotor task time 20.20.20.50.50.40.50.50.1-0.40.20.5-0.70.50.6-0.70.4-0.6-0.5-0.50.5-0.3-0.30.3-0.3
Vertical activity count, locomotor time 20.10.10.40.0-0.2-0.2-0.2-0.40.3-0.4-0.20.4-0.3-0.30.4-0.20.30.20.6-0.10.30.5-0.50.2
Light reinforcement 12.54.57.12.72.52.42.52.2-2.42.22.3-2.32.22.2-1.92.4-2.2-2.1-1.22.1-1.7-1.51.5-1.3
Light reinforcement 20.71.01.41.21.11.01.11.1-1.21.01.0-1.11.00.9-1.01.2-0.9-0.8-0.80.7-1.0-0.80.8-0.7
Bone: marrow area7.115.417.2-4.0-3.8-3.9-3.8-4.14.0-4.2-3.93.9-3.9-3.84.0-3.83.83.84.0-3.94.04.0-4.03.8
Bone: maximum diameter4.48.19.5-2.7-2.7-2.8-2.7-2.72.8-2.7-2.93.0-2.9-2.93.0-2.82.92.93.1-2.92.92.9-2.92.8
Bone: maximum force13.523.326.1-5.1-5.0-5.0-4.9-5.14.9-5.1-4.95.0-4.9-4.85.0-4.84.84.84.9-4.84.64.3-4.34.2
Bone: maximum moment13.623.427.2-5.2-5.0-5.0-5.0-5.14.9-5.2-4.95.0-4.9-4.85.0-4.74.84.84.9-4.84.64.3-4.34.2
Mean time between licks in bursts0.20.20.60.50.40.50.40.2-0.50.20.5-0.70.50.6-0.80.5-0.6-0.5-0.60.5-0.4-0.40.4-0.4
Mean num. licks in bursts0.20.21.2-0.5-0.3-0.1-0.3-0.2-0.1-0.20.0-0.10.10.1-0.20.2-0.2-0.1-0.30.1-0.8-1.11.1-1.0
Cd content in liver0.40.40.70.80.70.70.70.8-0.70.90.6-0.70.70.6-0.60.6-0.6-0.6-0.40.5-0.7-0.60.6-0.5
Co content in liver0.10.20.80.70.50.40.40.9-0.30.90.3-0.30.30.1-0.10.3-0.1-0.1-0.20.1-0.30.0-0.0-0.1
Cu content in liver1.01.21.8-1.1-1.1-1.1-1.1-0.51.2-0.6-1.21.2-1.1-1.21.3-1.21.21.20.7-1.30.90.9-0.91.1
Fe content in liver0.20.21.00.60.50.40.40.8-0.51.00.3-0.20.40.3-0.20.2-0.3-0.2-0.30.2-0.4-0.40.4-0.3
K content in liver0.50.50.9-0.7-0.7-0.7-0.7-0.10.7-0.4-0.70.9-0.7-0.90.9-0.70.90.70.5-0.70.40.5-0.50.5
Mg content in liver0.00.00.0-0.1-0.1-0.1-0.10.10.00.0-0.10.0-0.1-0.2-0.0-0.10.20.0-0.1-0.1-0.1-0.10.1-0.1
Mn content in liver0.00.00.1-0.0-0.0-0.1-0.0-0.2-0.0-0.2-0.10.2-0.1-0.10.30.10.10.10.0-0.00.30.0-0.00.3
Na content in liver0.00.00.20.10.20.20.20.4-0.00.50.1-0.10.10.0-0.20.1-0.00.0-0.10.0-0.00.1-0.10.2
Rb content in liver0.20.20.70.80.60.50.50.8-0.50.80.4-0.20.40.1-0.20.3-0.1-0.3-0.20.4-0.3-0.30.3-0.1
Se content in liver0.50.61.00.90.70.70.61.0-0.80.90.7-0.70.70.6-0.70.7-0.6-0.7-0.70.7-0.9-0.70.7-0.8
Sr content in liver0.70.61.3-0.5-0.7-0.8-0.7-0.90.7-0.6-0.80.9-0.8-1.00.9-0.81.00.81.1-0.90.80.5-0.50.8
Zn content in liver1.21.32.61.61.41.31.31.5-1.21.61.1-0.91.10.9-0.91.1-0.9-1.1-0.81.1-0.9-0.90.9-0.8
Bone: minimum diameter9.117.018.6-4.1-4.0-4.1-4.0-4.34.2-4.2-4.14.2-4.2-4.14.2-4.14.14.14.1-4.14.24.2-4.24.0
Time in familiar zone, hab. session 10.40.40.70.40.40.50.40.7-0.50.60.6-0.60.60.6-0.60.6-0.6-0.6-0.80.6-0.8-0.80.8-0.9
Time in novel zone, hab. session 10.40.41.1-0.3-0.3-0.4-0.3-0.60.5-0.5-0.50.6-0.6-0.50.6-0.50.60.60.8-0.50.91.0-1.01.1
Total zone transitions, hab. session 10.30.40.80.90.70.70.70.7-0.70.70.7-0.50.70.6-0.40.8-0.6-0.7-0.50.6-0.6-0.70.7-0.5
Total locomotion distance, hab. session 10.00.00.1-0.0-0.1-0.0-0.1-0.1-0.0-0.20.0-0.10.10.1-0.00.1-0.1-0.1-0.30.1-0.1-0.40.4-0.2
Locomotion velocity, hab. session 10.00.00.1-0.1-0.1-0.1-0.1-0.20.1-0.3-0.1-0.1-0.0-0.00.00.0-0.0-0.0-0.2-0.00.0-0.20.2-0.0
Time in familiar zone, hab. session 20.20.20.5-0.7-0.6-0.6-0.6-0.50.5-0.6-0.50.5-0.4-0.40.5-0.40.40.40.4-0.40.20.1-0.1-0.0
Time in novel zone, hab. session 20.20.20.60.70.80.60.80.4-0.50.50.5-0.50.40.5-0.50.5-0.5-0.4-0.30.40.10.2-0.20.3
Total zone transitions, hab. session 20.30.41.10.70.50.50.40.5-0.60.60.5-0.30.60.5-0.20.7-0.4-0.5-0.60.5-0.8-1.11.1-0.9
Total locomotion distance, hab. session 20.20.31.10.30.20.30.20.2-0.40.20.3-0.40.40.4-0.40.5-0.4-0.4-0.70.4-0.6-1.01.0-0.7
Locomotion velocity, hab. session 20.10.10.80.2-0.00.1-0.00.1-0.20.10.1-0.20.20.2-0.20.3-0.2-0.2-0.50.2-0.5-0.90.9-0.6
Novel to familiar place preference ratio1.92.03.2-1.3-1.2-1.3-1.2-1.21.3-1.1-1.31.5-1.4-1.31.5-1.41.31.31.8-1.41.61.7-1.71.7
Novelty place preference1.41.52.7-1.1-0.9-1.0-0.9-1.01.1-0.9-1.11.3-1.2-1.11.3-1.11.11.11.6-1.11.41.5-1.51.5
Time in novel zone, NPP test1.21.22.5-0.9-0.8-0.9-0.8-0.91.0-0.8-1.01.2-1.0-0.91.2-1.01.01.01.6-1.01.41.5-1.51.5
Total zone transitions, NPP test1.31.83.41.31.11.21.11.3-1.31.31.2-1.21.31.2-1.21.3-1.1-1.2-1.61.2-1.6-1.91.9-1.6
Total locomotion distance, NPP test1.92.64.21.51.41.51.41.4-1.61.41.5-1.61.61.6-1.61.6-1.6-1.6-1.91.5-1.8-2.02.0-1.8
Locomotion velocity, NPP test1.01.52.91.10.91.00.91.0-1.11.01.1-1.11.21.1-1.11.2-1.1-1.2-1.51.1-1.4-1.71.7-1.4
Intraocular pressure7.810.913.13.53.43.43.43.2-3.33.23.4-3.63.33.4-3.43.3-3.4-3.3-3.23.2-3.0-3.23.2-2.9
Delta distance traveled before/after self-admin0.10.10.2-0.5-0.5-0.4-0.5-0.30.3-0.3-0.30.2-0.2-0.40.2-0.20.30.10.1-0.3-0.10.1-0.1-0.3
Delta ambulatory time before/after self-admin0.00.00.1-0.2-0.2-0.2-0.3-0.10.1-0.1-0.20.1-0.1-0.20.2-0.10.20.00.3-0.1-0.10.0-0.0-0.2
Parametrial fat weight2.03.96.21.91.91.91.82.2-2.02.11.9-1.71.91.7-1.81.9-1.7-1.9-1.71.9-2.1-2.52.5-2.1
Pavlov. Cond. lever latency0.00.00.1-0.20.10.10.1-0.2-0.1-0.30.1-0.20.10.2-0.20.2-0.2-0.2-0.10.20.10.0-0.00.0
Pavlov. Cond. magazine entry latency0.00.00.2-0.2-0.2-0.1-0.2-0.0-0.0-0.1-0.00.10.0-0.00.1-0.00.0-0.0-0.1-0.0-0.3-0.40.4-0.4
Pavlov. Cond. change in total contacts0.10.10.3-0.2-0.3-0.3-0.4-0.10.4-0.1-0.40.3-0.3-0.30.3-0.50.30.40.3-0.40.20.3-0.30.3
Pavlov. Cond. index score0.10.20.3-0.2-0.4-0.4-0.4-0.10.4-0.1-0.50.6-0.4-0.60.6-0.50.60.60.5-0.60.30.3-0.30.4
Pavlov. Cond. latency score0.10.20.3-0.1-0.4-0.4-0.4-0.00.3-0.1-0.40.5-0.4-0.50.5-0.50.50.50.4-0.50.20.2-0.20.3
Pavlov. Cond. lever contacts0.20.20.60.70.40.40.40.7-0.40.80.4-0.30.40.3-0.30.3-0.3-0.2-0.30.3-0.5-0.50.5-0.4
Pavlov. Cond. magazine entry number0.00.00.0-0.00.00.00.1-0.20.0-0.20.0-0.1-0.00.0-0.10.1-0.1-0.00.10.10.20.2-0.20.2
Pavlov. Cond. intertrial magazine entries0.50.61.60.50.60.60.60.5-0.60.60.7-0.90.70.7-0.90.7-0.7-0.6-1.30.7-0.8-0.90.9-0.9
Pavlov. Cond. lever-magazine prob. diff.0.40.50.8-0.6-0.7-0.7-0.8-0.40.7-0.4-0.80.9-0.8-0.90.9-0.80.90.90.7-0.90.50.6-0.60.6
Pavlov. Cond. response bias0.00.00.20.10.00.1-0.00.2-0.10.30.1-0.00.10.1-0.10.0-0.1-0.1-0.20.1-0.4-0.40.4-0.4
Pavlov. Cond. lever latency0.00.00.0-0.1-0.0-0.0-0.0-0.20.0-0.2-0.0-0.0-0.00.00.1-0.00.0-0.00.00.00.0-0.10.10.0
Pavlov. Cond. magazine entry latency0.91.01.5-1.1-1.1-1.0-1.0-1.21.1-1.2-1.00.9-1.0-0.90.9-1.10.91.01.0-1.01.01.0-1.00.9
Pavlov. Cond. change in total contacts1.62.22.8-1.5-1.6-1.6-1.6-1.11.6-1.2-1.61.5-1.5-1.51.4-1.71.41.61.5-1.61.31.5-1.51.2
Pavlov. Cond. index score0.50.60.8-0.8-0.8-0.8-0.8-0.70.9-0.7-0.80.8-0.8-0.80.7-0.90.70.80.9-0.80.80.8-0.80.7
Pavlov. Cond. latency score0.60.70.8-0.8-0.9-0.9-0.9-0.80.9-0.8-0.90.8-0.9-0.80.7-0.90.80.90.9-0.90.80.8-0.80.7
Pavlov. Cond. lever contacts0.10.10.20.30.30.30.30.5-0.30.50.3-0.30.30.3-0.40.3-0.3-0.2-0.30.3-0.4-0.30.3-0.4
Pavlov. Cond. magazine entry number2.32.83.21.51.61.61.61.7-1.71.61.7-1.71.71.6-1.61.7-1.6-1.7-1.71.6-1.8-1.81.8-1.7
Pavlov. Cond. intertrial magazine entries4.76.27.22.42.52.52.42.6-2.52.72.5-2.42.52.4-2.52.6-2.3-2.5-2.72.4-2.6-2.52.5-2.5
Pavlov. Cond. lever-magazine prob. diff.0.91.11.4-1.0-1.1-1.1-1.1-1.01.1-1.0-1.11.0-1.1-1.00.9-1.21.01.11.1-1.11.11.2-1.21.0
Pavlov. Cond. response bias0.00.00.00.00.00.00.00.10.00.10.0-0.00.00.1-0.2-0.0-0.10.00.0-0.0-0.00.1-0.1-0.0
Time in closed arm before self-admin1.51.72.6-1.1-1.1-1.1-1.0-1.31.4-1.3-1.21.1-1.3-1.11.2-1.31.01.21.5-1.41.61.6-1.61.6
Time in closed arm after self-admin0.60.60.8-0.9-0.8-0.8-0.8-0.90.8-0.9-0.80.7-0.8-0.70.7-0.70.70.70.7-0.70.70.9-0.90.7
Time in open arm before self-admin0.80.91.6-0.8-0.8-0.9-0.9-0.80.8-0.8-0.91.2-0.9-1.11.2-0.91.21.01.2-0.60.80.9-0.90.9
Time in open arm after self-admin0.30.30.50.60.60.60.60.7-0.50.60.5-0.40.50.5-0.50.6-0.5-0.5-0.50.5-0.4-0.50.5-0.3
Bone: periosteal estimation12.024.926.6-5.0-5.0-5.0-5.0-5.15.1-5.1-5.05.1-5.0-5.05.2-4.95.05.05.1-5.04.94.8-4.84.6
Bone: periosteal perimeter10.517.418.9-4.3-4.3-4.3-4.3-4.24.3-4.2-4.34.3-4.2-4.24.3-4.24.24.24.2-4.24.03.8-3.83.7
Bone: post-yield work7.610.312.5-3.2-3.1-3.1-3.0-3.53.2-3.5-3.13.2-3.2-3.13.2-3.23.13.13.3-3.13.43.3-3.33.2
Progressive ratio test 1 active lever presses3.63.85.42.32.22.12.12.1-2.12.22.0-1.82.01.8-1.82.2-1.8-2.0-1.61.9-1.8-1.71.7-1.6
Progressive ratio test 1 breakpoint3.23.45.02.22.12.02.02.0-2.02.11.9-1.71.91.7-1.62.1-1.7-1.9-1.51.8-1.7-1.61.6-1.5
Progressive ratio test 1 inactive lever presses3.13.44.82.22.12.02.12.0-2.02.01.9-1.71.91.7-1.51.9-1.6-2.0-1.41.9-1.7-1.61.6-1.6
Progressive ratio test 2 active lever presses1.82.03.21.81.61.51.61.8-1.51.71.4-1.31.41.3-1.31.5-1.3-1.2-0.91.4-1.2-1.11.1-0.9
Progressive ratio test 2 breakpoint2.42.74.22.11.91.81.92.0-1.81.91.7-1.51.71.5-1.51.8-1.5-1.5-1.11.6-1.4-1.41.4-1.1
Progressive ratio test 2 inactive lever presses2.52.93.71.91.81.81.91.9-1.71.61.8-1.81.71.8-1.71.7-1.8-1.6-1.41.7-1.5-1.41.4-1.3
Incentive Sensitization - Responses0.10.10.30.0-0.2-0.2-0.1-0.10.1-0.2-0.20.3-0.2-0.20.2-0.30.20.50.5-0.30.30.2-0.20.5
Incentive Sensitization - Breakpoint0.00.00.10.1-0.0-0.0-0.00.10.0-0.1-0.10.1-0.1-0.10.0-0.10.10.40.4-0.10.20.1-0.10.4
Sum of active levers in priming session hrs 5-60.10.10.30.20.20.30.30.3-0.30.20.3-0.50.30.4-0.50.3-0.4-0.4-0.50.3-0.3-0.20.2-0.4
Progressive ratio0.00.00.30.20.10.10.10.1-0.20.10.1-0.00.20.20.10.2-0.1-0.3-0.10.2-0.3-0.10.1-0.6
Food seeking constrained by brief footshock0.20.20.50.50.50.40.40.6-0.60.70.4-0.10.40.10.20.4-0.2-0.6-0.10.3-0.5-0.60.6-0.4
Seeking ratio, punishment vs. effort0.00.00.20.00.10.00.10.20.00.2-0.00.1-0.0-0.20.1-0.00.10.10.1-0.10.1-0.20.20.4
Retroperitoneal fat weight0.31.02.10.80.80.90.71.3-0.91.20.9-0.81.00.8-0.80.9-0.8-0.6-1.10.8-1.5-1.41.4-1.4
Reaction time number correct1.01.42.8-1.4-1.3-1.2-1.2-1.61.3-1.7-1.10.8-1.2-0.90.9-1.10.91.10.3-1.21.21.4-1.41.2
Reaction time mean minus median8.311.012.93.13.13.23.13.4-3.33.43.3-3.33.43.4-3.43.1-3.3-3.3-3.53.4-3.6-3.33.3-3.5
Reaction time mean minus median AUC6.18.09.52.62.62.72.62.9-2.92.92.8-2.82.92.9-2.92.7-2.7-2.9-2.93.0-3.1-2.72.7-3.0
Reaction time num false alarms1.92.63.31.41.51.61.51.4-1.61.51.7-1.71.61.8-1.71.6-1.8-1.7-1.71.6-1.6-1.31.3-1.7
Reaction time num false alarms AUC2.83.84.81.71.81.91.81.8-1.91.82.0-2.12.02.2-2.12.0-2.2-2.0-2.11.9-2.1-1.71.7-2.2
Reaction time trials correct on left1.01.42.8-1.4-1.3-1.2-1.2-1.61.3-1.7-1.10.8-1.2-0.90.9-1.10.91.10.3-1.21.21.4-1.41.2
Reaction time trials on left0.71.12.3-1.3-1.1-1.0-1.1-1.51.1-1.5-1.00.7-1.0-0.70.7-0.90.80.90.1-1.01.11.2-1.21.0
Reaction time mean0.50.81.20.80.80.80.71.1-0.81.10.8-0.80.80.7-0.90.7-0.6-0.8-0.90.9-1.0-1.01.0-0.9
Reaction time mean AUC0.30.40.80.50.50.50.40.9-0.60.90.5-0.60.60.5-0.70.5-0.4-0.5-0.80.7-0.8-0.90.9-0.7
Median of all reaction times0.00.10.2-0.1-0.2-0.3-0.30.00.20.0-0.30.3-0.3-0.40.2-0.30.40.30.2-0.20.1-0.10.10.2
Reaction time omissions10.013.614.53.63.63.73.63.6-3.83.63.7-3.73.73.7-3.73.8-3.6-3.7-3.83.7-3.8-3.73.7-3.6
Reaction time false alarm rate2.63.74.51.81.81.91.82.0-1.92.11.9-1.92.02.0-1.91.9-2.0-2.0-1.61.9-2.1-1.81.8-2.1
Reaction time premature initiation rate5.37.19.63.13.02.92.92.9-2.72.92.8-2.72.72.6-2.52.6-2.7-2.7-2.42.5-2.4-2.32.3-2.1
Reaction time premature initiations2.73.84.82.22.12.12.21.9-2.01.92.1-2.12.02.1-1.91.9-2.1-2.0-2.11.8-1.7-1.51.5-1.4
Std. dev. reaction times6.18.69.92.82.72.82.73.1-2.93.12.9-2.92.92.9-2.92.8-2.8-2.9-3.13.0-3.1-3.03.0-3.1
Reaction time trials completed0.71.12.3-1.3-1.1-1.0-1.1-1.51.1-1.5-1.00.7-1.0-0.70.7-0.90.80.90.1-1.01.11.2-1.21.0
Reaction time trials AUC1.31.83.4-1.6-1.4-1.4-1.4-1.81.4-1.8-1.31.0-1.3-1.01.1-1.21.11.20.4-1.31.41.5-1.51.3
Run reversals in cocaine runway, females0.00.00.20.20.20.20.20.1-0.20.10.2-0.40.10.2-0.40.1-0.3-0.0-0.10.20.00.1-0.10.3
Run reversals in cocaine runway, males1.51.41.71.31.31.21.21.1-1.21.21.2-1.21.21.2-1.11.2-1.2-1.3-0.91.1-1.1-1.21.2-1.0
Latency to leave start box in cocaine runway0.00.00.10.20.10.10.10.1-0.10.10.1-0.20.10.1-0.20.1-0.0-0.2-0.00.3-0.0-0.10.1-0.2
Latency to leave start box in cocaine runway, F1.82.02.61.61.51.51.51.3-1.51.31.5-1.51.41.4-1.41.5-1.3-1.5-1.11.6-1.1-1.21.2-1.2
Latency to leave start box in cocaine runway, M1.91.82.3-1.5-1.5-1.5-1.5-1.41.4-1.4-1.41.3-1.4-1.41.3-1.41.41.41.1-1.31.21.2-1.21.0
Std. dev. time between licks in bursts0.80.91.81.31.11.11.11.0-1.01.01.0-1.01.01.0-1.01.0-1.0-1.0-0.81.0-0.8-0.50.5-0.6
Total sessions with >9 infusions0.40.40.90.90.70.70.70.8-0.70.90.6-0.50.60.4-0.70.8-0.4-0.6-0.40.5-0.7-0.50.5-0.5
Short access day 1 total inactive lever presses1.01.22.21.31.21.11.21.4-1.11.51.1-1.01.11.0-1.11.1-0.9-1.0-0.81.0-1.1-0.80.8-0.9
Short access day 10 total inactive lever presses0.40.50.80.80.90.80.90.7-0.60.70.8-0.80.70.9-0.70.6-0.8-0.7-0.30.7-0.2-0.40.4-0.2
Short access day 1 total infusions0.00.00.10.1-0.0-0.1-0.10.20.00.2-0.10.3-0.1-0.30.10.10.30.00.2-0.1-0.10.1-0.10.1
Short access day 10 total infusions0.50.61.00.90.80.80.70.9-0.81.00.7-0.70.80.7-0.70.7-0.8-0.6-0.90.7-0.9-0.60.6-0.8
Short access total infusions0.20.20.50.70.50.50.50.6-0.50.70.4-0.30.40.3-0.40.5-0.3-0.4-0.30.3-0.5-0.20.2-0.3
Short access day 1 locomotion0.10.10.20.50.30.20.30.3-0.20.30.10.30.1-0.30.20.20.3-0.10.40.10.10.1-0.10.2
Short access day 10 total locomotion0.20.20.70.80.80.60.80.4-0.50.40.5-0.30.40.3-0.40.5-0.4-0.60.20.50.2-0.20.20.2
Short access total locomotion0.30.30.91.00.90.70.80.7-0.60.70.5-0.30.50.2-0.40.6-0.3-0.60.10.5-0.1-0.20.2-0.0
One hour access (0.3 mA shock)0.10.10.20.50.30.40.40.5-0.40.50.4-0.30.40.4-0.40.3-0.5-0.1-0.40.3-0.5-0.10.1-0.3
Compulsive drug intake0.70.71.3-1.1-1.0-1.0-1.0-0.91.0-0.9-0.90.8-0.9-0.70.7-0.90.70.80.8-0.90.70.7-0.70.6
One hour access (shock baseline)0.00.00.20.40.20.20.20.3-0.20.20.1-0.00.2-0.0-0.00.1-0.00.0-0.10.1-0.30.0-0.0-0.1
Social response proportion0.10.10.40.30.20.30.30.4-0.20.40.3-0.60.30.5-0.60.2-0.5-0.4-0.40.1-0.4-0.10.1-0.4
Social responses7.59.612.03.33.23.33.33.2-3.03.23.2-3.43.23.5-3.32.9-3.4-3.2-3.03.0-2.8-2.52.5-2.6
Social time0.10.10.3-0.2-0.10.0-0.10.1-0.10.10.1-0.40.20.3-0.40.1-0.4-0.0-0.40.0-0.5-0.50.5-0.5
Soleus weight0.61.72.8-1.2-1.2-1.3-1.2-1.21.3-1.3-1.31.3-1.4-1.41.3-1.31.31.31.7-1.31.51.1-1.11.5
Bone: stiffness16.225.628.3-5.2-5.2-5.2-5.2-5.35.2-5.3-5.25.1-5.1-5.15.2-5.15.15.15.2-5.04.94.5-4.54.5
Tibialis anterior weight1.55.19.0-1.5-1.8-2.0-1.9-1.32.1-1.4-2.22.5-2.3-2.52.6-2.32.42.53.0-2.32.42.6-2.62.7
Time to tail flick, vehicle, before self-admin1.21.21.50.91.01.11.10.8-1.20.91.2-1.01.21.2-1.01.2-1.2-1.1-1.20.8-1.2-1.21.2-1.2
Time to tail flick, vehicle, after self-admin0.20.20.9-0.2-0.3-0.3-0.2-0.50.5-0.6-0.40.2-0.5-0.30.3-0.40.30.50.6-0.30.80.7-0.71.0
Time to tail flick, test, before self-admin0.50.51.10.60.60.60.60.6-0.70.50.7-0.70.70.7-0.70.6-0.6-0.5-0.90.9-0.7-1.11.1-0.6
Time to tail flick, test, after self-admin0.10.10.3-0.5-0.4-0.4-0.4-0.50.4-0.5-0.40.1-0.4-0.30.1-0.30.40.40.2-0.20.30.4-0.40.3
Delta time to tail flick, vehicle, before/after SA0.50.50.8-0.5-0.6-0.7-0.6-0.60.8-0.6-0.70.5-0.8-0.70.5-0.80.70.70.7-0.60.80.8-0.80.9
Delta time to tail flick, test, before/after SA0.30.20.5-0.4-0.4-0.5-0.4-0.50.4-0.4-0.50.5-0.5-0.50.5-0.40.50.30.6-0.50.50.7-0.70.3
Tibia length7.721.624.7-4.6-4.6-4.7-4.6-4.64.8-4.6-4.74.5-4.7-4.74.7-4.94.64.65.0-4.74.74.5-4.54.4
Ambulatory time before self-admin3.84.04.92.22.22.12.22.2-2.02.12.1-2.02.02.0-2.02.0-2.1-2.0-1.62.0-1.7-1.81.8-1.6
Ambulatory time after self-admin1.51.72.11.41.51.41.41.4-1.31.41.3-1.31.31.3-1.31.3-1.3-1.3-0.91.3-1.1-1.21.2-1.1
Bone: tissue strength0.70.71.1-1.0-0.9-0.8-0.8-1.00.9-1.0-0.80.8-0.8-0.80.8-0.80.70.70.8-0.80.90.9-0.90.8
Total heroin consumption2.22.64.3-1.3-1.3-1.4-1.3-1.41.5-1.5-1.51.7-1.6-1.61.9-1.61.61.71.8-1.41.91.7-1.72.1
Bone: trabecular number5.58.513.1-3.6-3.4-3.3-3.4-3.33.1-3.3-3.12.9-2.9-2.92.9-2.92.92.92.7-3.02.32.0-2.01.7
Bone: trabecular spacing1.92.54.32.12.01.82.01.8-1.71.71.7-1.61.61.6-1.71.5-1.6-1.6-1.51.6-1.0-0.80.8-0.7
Bone: trabecular thickness0.10.10.50.00.10.20.10.3-0.30.30.2-0.10.30.2-0.10.4-0.3-0.3-0.00.3-0.6-0.60.6-0.7
Bone: trabecular tissue density0.10.10.20.40.50.40.50.1-0.40.20.4-0.10.30.3-0.10.4-0.3-0.3-0.10.4-0.00.1-0.10.1
Water consumed over 24 hours0.00.00.1-0.2-0.2-0.1-0.1-0.30.1-0.3-0.10.1-0.0-0.10.20.10.0-0.00.0-0.0-0.1-0.10.1-0.2
Number of responses in last shaping day0.30.31.1-0.0-0.1-0.3-0.2-0.00.4-0.1-0.40.6-0.4-0.70.7-0.40.70.41.0-0.40.50.9-0.90.7