Hub : Genes

Josd2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IL mRNA stability Josd2 0.16 0.11 6.7e-03 0.02 0.04 0.01 0.02 9.4e-02 3.7e-02 2.0e-01 1.3e-01
2 NAcc gene expression Josd2 0.02 0.01 2.5e-03 0 0.01 0 0.01 7.1e-02 1.5e-02 8.6e-02 2.0e-02
3 IC mRNA stability Josd2 0.23 0.12 1.6e-09 0.19 0.22 0.2 0.21 3.0e-08 1.8e-09 6.4e-09 3.3e-09
4 Brain mRNA stability Josd2 0.27 0.1 0.0e+00 0.35 0.36 0.36 0.36 1.6e-33 5.1e-35 3.7e-35 5.0e-35
5 Brain isoform ratio XM_039104787.2 0.08 0.04 7.3e-08 0.07 0.05 0.06 0.06 2.0e-07 1.2e-05 6.5e-06 4.3e-06
6 pVTA mRNA stability Josd2 0.11 0.06 2.3e-11 0.14 0.14 0.14 0.15 1.2e-11 1.6e-11 1.7e-11 3.4e-12
7 PL gene expression Josd2 0.03 0.02 2.6e-04 0.03 0.03 0.03 0.03 1.5e-04 2.7e-04 1.7e-04 2.1e-04
8 PL mRNA stability Josd2 0.18 0.09 0.0e+00 0.19 0.19 0.2 0.2 2.2e-20 1.1e-20 2.9e-21 1.5e-21
9 NAcc mRNA stability Josd2 0.1 0.05 0.0e+00 0.13 0.11 0.11 0.13 4.1e-19 7.3e-17 6.4e-17 9.1e-19
10 Brain isoform ratio XM_006228998.5 0.02 0.02 6.6e-03 0.02 0.01 0.01 0.01 5.2e-03 2.2e-02 4.5e-02 1.7e-02
11 Brain gene expression Josd2 0.11 0.06 4.9e-12 0.14 0.12 0.13 0.14 2.8e-13 1.3e-11 2.5e-12 1.1e-12
12 BLA mRNA stability Josd2 0.24 0.12 9.0e-12 0.19 0.15 0.18 0.18 3.3e-10 2.1e-08 1.0e-09 7.3e-10
13 OFC mRNA stability Josd2 0.3 0.13 3.8e-06 0.14 0.2 0.15 0.17 3.3e-04 1.4e-05 2.2e-04 7.7e-05
14 LHb mRNA stability Josd2 0.19 0.1 4.2e-04 0.11 0.12 0.12 0.11 1.6e-03 1.1e-03 7.4e-04 1.5e-03
15 PL alternative TSS NM_001106256.2 0.05 0.03 2.0e-04 0.04 0.02 0.04 0.03 2.6e-05 3.8e-03 1.6e-05 4.3e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.30.61.0-0.40.6-0.70.7-0.7-0.7-0.9-0.70.71.0-1.00.8-0.80.7-1.0
Area under the delay curve0.40.61.30.6-0.80.7-0.91.00.70.20.7-0.7-0.60.3-0.61.0-1.20.7
BMI with tail0.41.32.2-0.81.1-1.01.2-1.2-1.1-1.4-1.21.20.4-1.51.3-1.31.3-0.6
BMI without tail0.00.10.30.10.1-0.30.3-0.3-0.2-0.4-0.20.2-0.6-0.50.4-0.20.30.1
Body weight0.73.26.42.2-2.01.7-1.71.71.81.61.8-1.8-2.51.5-1.61.7-1.60.9
Weight adjusted by age0.00.10.2-0.20.2-0.10.2-0.2-0.3-0.2-0.40.2-0.4-0.1-0.0-0.30.3-0.3
Bone surface0.91.82.7-0.91.1-1.51.3-1.2-1.3-1.6-1.31.41.5-1.61.6-1.21.2-1.5
Bone volume0.30.71.6-0.30.6-0.80.8-0.8-0.8-0.9-0.70.81.0-0.90.9-0.80.8-1.2
Breakpoint value in progressive ratio session0.20.40.9-0.20.5-0.60.7-0.6-0.7-0.3-0.81.00.4-0.30.4-0.80.7-0.6
Number of licking bursts0.10.20.9-0.90.6-0.60.4-0.4-0.4-0.3-0.40.20.4-0.30.3-0.10.20.3
Context. condit. distance diff. score7.99.612.2-3.53.3-3.53.1-3.0-3.4-3.2-3.43.33.3-3.23.2-2.82.6-0.3
Locomotion velocity, session 11.61.83.9-2.01.6-1.31.4-1.4-1.2-1.3-1.21.21.3-1.31.3-1.21.3-0.1
Locomotion distance, session 13.84.95.8-2.22.3-2.22.4-2.4-2.2-2.2-2.22.22.3-2.22.3-2.32.4-0.8
Locomotion velocity, session 20.60.81.5-1.21.0-0.80.9-0.9-0.8-0.7-0.80.70.9-0.70.8-0.80.9-0.8
Locomotion distance, session 20.50.71.1-1.01.0-1.01.0-1.1-0.8-0.7-0.80.80.9-0.70.8-0.81.0-0.5
Locomotion velocity, session 30.60.72.5-1.61.1-1.00.9-1.0-0.7-0.7-0.70.70.7-0.70.6-0.60.8-0.5
Locomotion distance, session 30.10.10.2-0.10.2-0.20.4-0.4-0.2-0.2-0.20.20.1-0.20.2-0.40.5-0.2
Stereotopy head waving bouts, day 32.02.43.3-1.81.7-1.71.7-1.8-1.5-1.4-1.51.41.5-1.41.4-1.51.7-1.1
Stereotopy head waving duration, day 32.12.73.9-2.01.8-1.81.8-1.9-1.5-1.6-1.51.51.5-1.61.5-1.51.7-0.9
Locomotion velocity, session 70.20.20.7-0.2-0.20.3-0.50.50.30.20.3-0.4-0.50.2-0.50.7-0.80.9
Locomotion distance, session 70.20.20.4-0.50.5-0.60.4-0.4-0.5-0.6-0.50.50.3-0.60.4-0.30.3-0.2
Stereotopy head waving bouts, day 70.10.10.4-0.3-0.00.2-0.20.20.2-0.10.2-0.2-0.2-0.1-0.20.4-0.40.6
Stereotopy head waving duration, day 70.00.00.1-0.40.00.1-0.20.20.2-0.10.2-0.2-0.2-0.1-0.10.3-0.40.3
Locomotion velocity, session 83.94.78.8-3.02.6-2.22.2-2.2-2.2-2.2-2.22.22.0-2.22.1-2.12.0-0.6
Locomotion distance, session 89.413.618.0-4.24.0-4.03.7-3.7-3.9-3.8-3.93.93.7-3.83.8-3.53.3-0.7
Degree of sensitization distance0.20.20.3-0.50.4-0.50.3-0.3-0.5-0.5-0.50.50.5-0.50.4-0.20.1-0.4
Degree of sensitization stereotypy0.80.91.50.5-0.80.9-1.11.10.90.60.9-0.9-1.00.6-0.81.1-1.21.2
Conditioned locomotion0.10.10.10.0-0.20.1-0.30.30.20.40.2-0.1-0.30.4-0.20.4-0.4-0.0
Cocaine response after cond. corrected1.32.02.91.6-1.51.7-1.41.41.41.51.4-1.4-1.51.6-1.41.1-1.10.6
Cocaine response after cond. not corrected1.21.72.41.4-1.31.5-1.31.31.21.41.3-1.3-1.51.4-1.31.1-1.10.3
Cocaine response before conditioning0.20.20.6-0.80.6-0.60.3-0.3-0.4-0.7-0.50.50.1-0.70.5-0.20.1-0.5
Saline control response0.20.20.40.4-0.50.4-0.40.30.60.60.6-0.6-0.30.6-0.50.5-0.40.2
Bone: connectivity density2.03.25.1-1.71.7-1.91.7-1.6-1.8-2.2-1.81.82.0-2.31.9-1.61.5-0.9
Bone: cortical apparent density1.11.82.61.5-1.51.3-1.41.31.31.61.3-1.3-1.01.6-1.51.3-1.3-0.3
Bone: cortical area0.30.41.21.1-0.80.6-0.60.60.70.60.7-0.7-0.40.5-0.70.6-0.6-0.0
Bone: cortical porosity0.10.10.7-0.80.4-0.10.1-0.1-0.10.4-0.1-0.00.40.40.1-0.10.0-0.7
Bone: cortical porosity0.30.31.5-1.20.8-0.50.5-0.4-0.50.0-0.50.30.8-0.00.4-0.40.3-0.6
Bone: cortical thickness0.61.01.31.1-1.11.1-1.11.11.01.11.0-1.1-0.71.1-1.11.0-1.0-0.1
Bone: cortical thickness0.10.20.3-0.20.3-0.30.4-0.4-0.5-0.2-0.50.30.5-0.20.4-0.50.5-0.5
Bone: cortical tissue density1.11.82.61.5-1.51.3-1.41.41.31.61.3-1.3-1.11.6-1.51.4-1.3-0.2
Condit. Reinf. active minus inactive responses0.00.00.10.2-0.2-0.0-0.10.2-0.00.1-0.0-0.0-0.10.1-0.10.2-0.2-0.3
Condit. Reinf. active-inactive response ratio0.00.00.1-0.00.0-0.1-0.10.2-0.1-0.3-0.10.2-0.1-0.30.20.0-0.2-0.4
Condit. Reinf. active responses0.20.30.40.6-0.60.4-0.60.60.50.60.5-0.5-0.50.6-0.60.6-0.60.2
Condit. Reinf. inactive responses0.71.01.41.1-1.00.8-0.80.71.11.21.1-1.2-0.91.2-1.01.0-0.70.8
Incentive salience index mean0.00.00.10.2-0.20.1-0.20.20.00.20.0-0.0-0.10.2-0.10.2-0.2-0.3
Condit. Reinf. lever presses0.91.31.71.3-1.21.2-1.21.21.11.31.1-1.2-1.11.3-1.21.1-1.10.2
Condit. Reinf. active minus inactive responses0.30.41.40.4-0.50.2-0.50.50.60.60.6-0.7-0.60.6-0.60.8-0.71.2
Condit. Reinf. active-inactive response ratio0.10.20.40.1-0.30.4-0.40.30.50.60.5-0.6-0.40.6-0.60.6-0.40.4
Condit. Reinf. active responses0.20.30.90.6-0.60.2-0.50.40.60.50.6-0.6-0.60.5-0.50.8-0.61.0
Condit. Reinf. inactive responses0.00.00.30.5-0.2-0.30.1-0.1-0.1-0.2-0.10.1-0.0-0.30.2-0.10.1-0.0
Condit. Reinf. lever presses0.10.10.80.5-0.4-0.2-0.20.10.30.10.3-0.3-0.10.1-0.20.5-0.30.9
Condit. Reinf. lever reinforcers received0.20.31.10.7-0.60.1-0.40.40.50.50.5-0.5-0.50.4-0.40.7-0.61.1
Conditioned reinforcement - actives0.00.10.2-0.20.3-0.30.4-0.4-0.4-0.1-0.40.5-0.30.20.3-0.40.5-0.3
Conditioned reinforcement - inactives0.00.10.4-0.1-0.0-0.1-0.20.2-0.00.0-0.00.1-0.5-0.10.10.3-0.40.6
Conditioned locomotion0.71.01.5-0.91.0-0.91.1-1.2-1.0-0.9-0.90.91.0-0.61.2-1.11.2-0.7
Patch foraging indifference point 0 sec0.41.13.10.6-0.90.3-1.01.01.10.81.1-1.0-0.80.8-0.91.5-1.51.7
Patch foraging indifference point AUC0.51.31.8-1.21.2-1.31.1-1.1-1.3-1.1-1.31.11.3-1.11.0-1.11.1-0.6
Delay disc. indifference point, 0s delay0.40.40.6-0.70.7-0.80.8-0.8-0.6-0.7-0.60.50.6-0.60.6-0.70.7-0.2
Delay disc. indifference point, 16s delay0.91.32.10.9-1.11.0-1.31.31.10.81.2-1.3-1.20.9-1.21.4-1.40.7
Delay disc. indifference point, 2s delay2.32.64.1-1.71.6-1.71.5-1.4-1.6-2.0-1.61.62.0-1.91.8-1.41.2-0.3
Delay disc. indifference point, 24s delay0.10.10.3-0.40.2-0.3-0.10.2-0.3-0.5-0.30.4-0.3-0.50.30.2-0.40.5
Delay disc. indifference point, 4s delay0.50.50.90.7-0.80.7-0.80.80.80.30.8-0.8-0.60.4-0.60.8-1.00.6
Delay disc. indifference point, 8s delay1.32.33.81.4-1.61.5-1.71.81.51.31.4-1.4-1.31.4-1.31.7-2.01.0
Indifference point function ln k0.00.00.20.3-0.20.0-0.10.00.20.10.2-0.1-0.10.00.00.1-0.10.4
Indifference point function log k0.00.00.20.3-0.20.0-0.10.00.20.10.2-0.1-0.10.00.00.1-0.10.4
Patch foraging total patch changes 0 sec0.41.22.90.6-0.90.4-1.11.11.20.81.2-1.1-0.80.8-0.91.6-1.61.7
Patch foraging total patch changes 12 sec0.00.00.10.1-0.0-0.30.1-0.1-0.1-0.0-0.0-0.00.3-0.00.10.1-0.10.2
Patch foraging total patch changes 18 sec0.71.73.5-1.91.5-1.91.2-1.2-1.3-1.3-1.21.21.7-1.31.3-0.70.70.3
Patch foraging total patch changes 24 sec1.03.34.7-1.71.8-2.01.8-1.8-1.9-2.0-1.91.82.2-2.01.7-1.71.7-0.7
Patch foraging total patch changes 6 sec0.10.10.60.0-0.2-0.2-0.30.30.20.00.2-0.2-0.40.0-0.10.6-0.60.8
Patch foraging time to switch 0 sec0.20.91.60.6-0.81.3-0.90.81.11.11.1-1.2-1.21.1-0.90.8-0.7-0.0
Patch foraging water rate 0 sec0.10.30.9-0.70.6-1.00.4-0.4-0.5-0.6-0.50.60.7-0.60.4-0.0-0.00.8
Patch foraging water rate 12 sec0.20.61.4-0.80.8-1.00.7-0.7-0.7-1.2-0.80.80.8-1.20.9-0.50.50.0
Patch foraging water rate 18 sec0.10.21.1-0.10.1-0.2-0.00.1-0.2-0.9-0.30.3-0.0-1.10.40.0-0.20.4
Patch foraging water rate 24 sec1.31.82.9-1.11.3-1.41.3-1.2-1.3-1.6-1.41.41.7-1.61.6-1.31.2-0.5
Patch foraging water rate 6 sec0.71.02.6-0.60.8-1.20.9-0.9-0.8-1.3-0.90.91.6-1.41.0-0.80.8-0.1
Seeking ratio, delayed vs. immediate footshock0.30.51.0-0.40.6-0.50.8-0.8-0.8-0.7-0.70.70.5-0.80.5-0.91.0-0.3
Distance traveled before self-admin0.40.91.4-0.70.9-1.11.1-1.0-0.9-0.9-1.01.11.2-0.80.8-0.91.0-0.1
Distance traveled after self-admin0.10.20.7-0.20.4-0.30.3-0.2-0.5-0.4-0.50.80.1-0.50.6-0.60.4-0.2
Extensor digitorum longus weight2.28.610.1-3.23.2-3.03.0-2.9-3.2-3.1-3.23.12.8-3.03.1-3.02.8-0.7
Bone: elastic displacement1.72.23.8-2.01.7-1.51.3-1.3-1.6-1.6-1.61.61.4-1.61.6-1.31.1-0.5
Bone: elastic work0.30.50.8-0.40.6-0.60.6-0.5-0.8-0.9-0.80.70.8-0.90.8-0.70.6-0.2
Bone: endosteal estimation0.41.01.9-0.10.7-1.01.1-1.1-0.9-1.3-0.91.01.0-1.41.1-1.11.2-0.7
Bone: endosteal perimeter0.10.30.80.20.2-0.50.6-0.6-0.4-0.9-0.40.40.4-0.90.6-0.50.6-0.2
Epididymis fat weight0.00.10.2-0.30.3-0.20.3-0.3-0.30.2-0.30.2-0.30.10.1-0.30.3-0.4
Delta time in closed arm before/after self-admin1.21.12.00.7-0.91.0-0.90.91.11.41.1-1.3-1.01.4-1.41.1-1.00.4
Delta time in open arm before/after self-admin0.10.10.3-0.20.3-0.30.3-0.3-0.3-0.3-0.30.3-0.0-0.30.5-0.30.40.1
Diff in mean of infusions in LGA sessions0.30.61.0-0.80.8-1.00.7-0.8-0.9-0.6-0.90.90.2-0.60.9-0.60.6-0.1
Delay discount exponential model param0.40.61.4-0.70.8-0.71.0-1.0-0.8-0.2-0.80.80.5-0.30.6-1.01.2-0.7
Extinction: sum of active levers before priming0.30.51.10.20.3-0.30.7-0.8-0.6-0.1-0.70.70.7-0.10.4-1.01.1-1.1
Active lever presses in extinction session 60.90.91.7-0.50.8-0.81.1-1.1-0.9-0.8-0.90.90.9-0.80.6-1.21.3-1.3
Bone: final force0.10.20.70.8-0.60.4-0.40.50.30.20.3-0.3-0.30.1-0.30.2-0.3-0.6
Bone: final moment0.20.41.21.1-0.80.7-0.70.70.60.50.5-0.5-0.50.5-0.50.5-0.5-0.5
Food consumed during 24 hour testing period0.71.31.81.0-1.11.0-1.21.21.11.31.2-1.2-1.31.2-1.21.3-1.30.5
Glucose0.10.20.30.0-0.30.5-0.40.40.50.40.5-0.6-0.40.4-0.30.4-0.40.0
Heart weight0.50.81.9-0.60.8-0.90.8-0.8-1.0-1.3-1.01.00.5-1.41.1-0.90.7-0.3
Delay discount hyperbolic model param0.20.30.9-0.40.5-0.50.7-0.8-0.50.0-0.50.50.2-0.10.3-0.70.9-0.5
Intermittent access intake day 1-15 change0.42.13.0-1.21.5-1.71.7-1.7-1.6-1.5-1.61.50.7-1.51.3-1.61.7-0.4
Intermittent access intake escalation0.31.42.2-0.81.2-1.41.4-1.5-1.3-1.3-1.31.20.5-1.31.1-1.41.5-0.4
Intermittent access intake escalation 20.10.20.5-0.10.3-0.40.4-0.4-0.5-0.2-0.50.4-0.7-0.30.3-0.50.40.1
Intermitt. access day 1 inactive lever presses0.10.91.8-0.91.0-1.41.0-0.9-1.1-1.0-1.01.00.7-1.01.1-0.80.80.3
Intermitt. access day 15 inactive lever presses0.74.05.92.0-2.11.7-2.22.31.91.81.9-1.9-2.21.7-2.02.3-2.41.4
Intermitt. access escalation Index0.10.30.70.7-0.60.8-0.60.60.60.50.6-0.7-0.60.5-0.80.4-0.4-0.1
Intermittent access day 1 total infusions0.72.02.71.4-1.51.5-1.61.61.51.41.4-1.3-1.01.4-1.31.6-1.60.5
Intermittent access day 15 total infusions0.10.20.50.7-0.60.4-0.50.50.50.30.5-0.5-0.40.3-0.60.5-0.50.3
Intermittent access terminal intake (last 3 days)0.00.00.10.3-0.2-0.0-0.10.10.00.2-0.0-0.0-0.30.3-0.10.1-0.10.2
Intermittent access total infusions0.81.01.31.2-1.11.0-1.11.11.01.01.0-1.0-0.81.0-1.11.0-1.00.1
Intermittent access day 1 locomotion0.10.10.20.4-0.40.3-0.40.30.50.10.4-0.40.10.2-0.10.4-0.40.1
Intermittent access day 15 total locomotion0.52.12.7-1.31.4-1.61.5-1.6-1.5-1.5-1.51.51.6-1.41.6-1.41.5-0.6
Intermittent access total locomotion0.00.10.10.00.1-0.20.3-0.3-0.1-0.3-0.20.10.3-0.20.3-0.20.3-0.2
Intermittent access standard deviation0.00.00.0-0.10.1-0.10.1-0.0-0.1-0.1-0.1-0.00.0-0.2-0.0-0.10.00.2
Left kidney weight2.419.627.45.2-4.94.6-4.54.54.64.54.6-4.6-4.64.3-4.54.2-4.21.6
Right kidney weight3.021.028.75.4-5.14.8-4.84.84.84.34.8-4.8-4.84.1-4.64.5-4.51.8
Cocaine induced anxiety0.20.52.00.6-0.70.8-0.70.70.70.60.7-0.7-1.40.6-0.70.6-0.70.4
Post-drug Anxiety0.10.10.4-0.60.40.10.1-0.1-0.2-0.5-0.20.2-0.3-0.50.2-0.20.1-0.2
Baseline Anxiety0.50.91.5-1.21.0-0.80.9-0.8-0.9-1.0-0.90.91.2-1.00.9-0.90.8-0.8
Tail length1.36.99.23.0-2.92.4-2.72.82.72.52.7-2.7-2.52.4-2.62.9-2.81.5
Length with tail2.310.214.03.7-3.53.1-3.33.33.33.23.3-3.3-3.23.1-3.33.2-3.11.5
Length without tail0.52.73.41.6-1.71.6-1.61.61.71.81.7-1.7-1.81.7-1.81.7-1.70.9
Times rat made contact with spout0.20.20.4-0.2-0.20.1-0.30.20.40.50.4-0.6-0.60.4-0.50.6-0.40.4
Lifetime Intake2.53.14.02.0-1.91.8-1.91.91.81.71.8-1.8-1.51.7-1.81.8-1.80.5
Liver weight, left0.00.10.50.4-0.1-0.10.2-0.2-0.2-0.1-0.10.00.2-0.10.2-0.40.5-0.7
Liver weight, right0.10.10.40.2-0.30.1-0.30.30.4-0.10.3-0.2-0.6-0.2-0.20.4-0.40.3
Locomotor activity1.01.62.11.4-1.41.3-1.41.41.31.01.3-1.2-1.41.0-1.31.3-1.40.8
Locomotor testing distance0.10.30.60.8-0.60.6-0.60.60.60.20.6-0.5-0.60.2-0.50.5-0.50.4
Locomotor testing rearing0.20.71.31.1-1.00.8-0.80.80.90.70.9-1.0-0.80.7-0.80.8-0.70.3
Locomotion in novel chamber1.31.83.81.7-1.51.5-1.31.41.11.51.1-1.1-1.91.6-1.11.0-1.10.8
Locomotion in novel chamber post-restriction0.31.01.7-0.60.9-0.91.1-1.3-1.1-0.6-1.01.00.6-0.70.9-1.31.3-1.0
Fecal boli incidents, locomotor time 10.61.42.70.8-1.21.2-1.41.51.01.41.0-1.1-0.91.1-1.21.5-1.60.6
Change in fecal boli incidents, locomotor task0.00.00.1-0.30.2-0.10.1-0.1-0.2-0.4-0.1-0.1-0.0-0.30.1-0.10.10.1
Time >=10cm from walls, locomotor time 14.25.27.82.8-2.62.5-2.42.42.32.32.2-2.3-1.82.3-2.42.2-2.21.0
Bouts of movement, locomotor time 12.83.64.72.0-2.02.1-1.91.92.11.92.0-2.0-2.21.9-1.91.8-1.70.6
Total resting periods, locomotor time 12.63.04.31.7-1.81.9-1.71.71.91.81.8-1.9-2.11.8-1.71.7-1.60.6
Rest time, locomotor task time 10.10.10.8-0.2-0.10.1-0.20.10.00.90.1-0.4-0.20.7-0.30.3-0.20.1
Distance moved, locomotor task time 11.95.47.9-1.92.3-2.32.4-2.4-2.2-2.8-2.22.42.2-2.72.3-2.62.5-1.3
Vertical activity count, locomotor time 10.00.10.20.4-0.20.0-0.00.10.3-0.40.20.2-0.2-0.40.0-0.0-0.00.2
Time >=10cm from walls, locomotor time 20.41.01.31.0-1.11.1-1.11.10.91.00.9-1.1-1.10.8-1.11.1-1.10.7
Bouts of movement, locomotor time 20.00.10.50.7-0.40.2-0.20.10.30.40.3-0.40.30.6-0.50.2-0.10.2
Total resting periods, locomotor time 20.00.20.60.8-0.50.3-0.20.20.40.50.3-0.40.20.7-0.50.2-0.10.1
Rest time, locomotor task time 20.40.61.60.9-0.80.9-0.70.70.61.30.6-0.8-0.61.2-0.90.6-0.6-0.1
Distance moved, locomotor task time 21.41.92.9-1.41.5-1.51.5-1.6-1.3-1.7-1.31.30.8-1.61.4-1.41.5-0.5
Vertical activity count, locomotor time 20.20.41.80.3-0.40.4-0.50.60.60.20.6-0.5-1.30.2-0.50.6-0.70.7
Light reinforcement 10.10.40.8-0.70.7-0.90.6-0.6-0.6-0.7-0.60.80.5-0.80.9-0.40.40.4
Light reinforcement 20.10.31.0-1.00.7-0.50.5-0.5-0.4-0.3-0.40.50.6-0.40.5-0.40.40.1
Bone: marrow area0.51.12.0-0.20.7-1.01.1-1.1-1.0-1.4-1.01.01.0-1.41.2-1.21.2-0.6
Bone: maximum diameter0.30.61.71.3-1.00.8-0.80.80.90.40.9-0.9-0.60.5-0.80.7-0.70.6
Bone: maximum force0.20.41.40.40.2-0.30.5-0.4-0.5-0.8-0.50.60.5-0.80.6-0.80.7-1.2
Bone: maximum moment0.10.21.10.6-0.1-0.10.2-0.2-0.3-0.4-0.30.30.4-0.50.4-0.50.5-1.1
Mean time between licks in bursts0.00.00.1-0.1-0.00.2-0.20.20.20.00.2-0.3-0.20.10.10.2-0.20.3
Mean num. licks in bursts0.00.00.20.4-0.20.1-0.10.00.10.10.2-0.1-0.20.1-0.1-0.00.1-0.2
Cd content in liver1.82.02.71.4-1.41.3-1.31.31.41.61.4-1.5-1.61.6-1.51.5-1.30.9
Co content in liver0.40.40.80.7-0.70.8-0.70.60.70.60.8-0.7-0.90.6-0.60.6-0.50.0
Cu content in liver1.51.82.3-1.11.3-1.31.3-1.3-1.4-1.5-1.41.41.3-1.51.4-1.41.4-0.9
Fe content in liver2.02.43.5-1.81.7-1.81.6-1.6-1.6-1.6-1.51.51.9-1.71.6-1.31.3-0.2
K content in liver0.10.10.4-0.1-0.20.2-0.40.50.20.00.3-0.2-0.30.0-0.20.6-0.60.6
Mg content in liver0.40.51.00.3-0.60.7-0.80.90.60.50.6-0.5-0.80.4-0.50.8-1.00.8
Mn content in liver0.00.00.1-0.10.00.2-0.10.10.0-0.10.1-0.0-0.3-0.1-0.2-0.0-0.0-0.2
Na content in liver0.10.10.7-0.30.3-0.20.3-0.2-0.2-0.3-0.20.30.9-0.30.2-0.30.3-0.5
Rb content in liver1.92.23.7-1.91.7-1.81.4-1.4-1.5-1.7-1.51.51.1-1.61.6-1.11.1-0.2
Se content in liver0.20.30.8-0.30.4-0.50.3-0.2-0.6-0.9-0.60.60.3-0.90.7-0.40.20.2
Sr content in liver0.10.10.3-0.10.2-0.30.4-0.4-0.1-0.1-0.10.10.5-0.10.1-0.20.3-0.2
Zn content in liver0.20.30.70.5-0.50.4-0.60.60.40.30.4-0.3-0.60.3-0.40.6-0.60.8
Bone: minimum diameter0.91.82.5-0.61.1-1.31.4-1.4-1.3-1.6-1.31.31.5-1.61.5-1.41.4-0.9
Time in familiar zone, hab. session 10.10.10.60.4-0.30.2-0.20.20.30.00.3-0.2-0.30.0-0.20.3-0.20.8
Time in novel zone, hab. session 10.10.10.3-0.60.4-0.30.3-0.2-0.4-0.2-0.40.40.4-0.20.4-0.30.20.3
Total zone transitions, hab. session 10.81.11.5-1.21.2-1.01.1-1.0-1.2-1.0-1.21.11.0-1.01.1-1.11.0-0.3
Total locomotion distance, hab. session 10.60.81.0-1.01.0-1.00.9-0.8-1.0-0.9-1.01.00.7-0.91.0-0.90.8-0.3
Locomotion velocity, hab. session 10.10.20.3-0.60.5-0.50.4-0.4-0.5-0.4-0.50.50.2-0.40.5-0.40.3-0.1
Time in familiar zone, hab. session 20.10.10.90.8-0.4-0.1-0.20.20.10.10.1-0.1-0.40.1-0.10.3-0.20.9
Time in novel zone, hab. session 21.01.11.9-1.41.2-0.91.0-1.0-1.1-1.1-1.11.01.2-1.11.0-1.11.0-0.3
Total zone transitions, hab. session 21.31.72.3-1.51.5-1.51.5-1.5-1.3-1.1-1.31.31.3-1.11.3-1.21.40.0
Total locomotion distance, hab. session 21.11.52.3-1.31.3-1.51.3-1.3-1.3-1.0-1.31.31.2-1.01.3-1.11.20.0
Locomotion velocity, hab. session 20.40.61.0-0.90.9-1.00.8-0.9-0.8-0.5-0.80.80.7-0.50.8-0.60.70.1
Novel to familiar place preference ratio0.40.51.80.1-0.40.5-0.70.80.50.60.5-0.6-0.50.6-0.60.9-1.01.3
Novelty place preference0.20.31.3-0.1-0.20.3-0.50.50.40.50.4-0.4-0.30.5-0.50.7-0.81.1
Time in novel zone, NPP test0.20.22.0-0.2-0.10.1-0.40.40.20.30.2-0.3-0.20.3-0.30.6-0.71.4
Total zone transitions, NPP test1.82.73.7-1.61.7-1.51.8-1.8-1.7-1.5-1.71.61.6-1.51.7-1.91.9-0.8
Total locomotion distance, NPP test4.25.86.9-2.22.4-2.52.6-2.6-2.6-2.3-2.62.52.4-2.32.5-2.62.6-1.3
Locomotion velocity, NPP test3.24.55.4-2.02.1-2.12.2-2.2-2.2-1.9-2.22.12.2-1.92.1-2.32.3-1.8
Intraocular pressure4.26.99.33.1-2.93.0-2.82.92.72.62.7-2.6-2.72.7-2.52.4-2.50.5
Delta distance traveled before/after self-admin0.40.41.50.6-0.60.7-0.80.90.40.60.4-0.2-1.20.5-0.30.5-0.80.3
Delta ambulatory time before/after self-admin0.10.11.0-0.1-0.10.2-0.30.4-0.00.20.00.1-1.00.10.10.2-0.40.3
Parametrial fat weight1.43.34.41.5-1.82.1-1.91.92.11.82.1-2.1-1.81.6-2.01.9-1.80.7
Pavlov. Cond. lever latency0.60.71.1-0.90.9-1.00.9-0.9-0.8-1.1-0.80.90.7-1.10.9-0.70.70.3
Pavlov. Cond. magazine entry latency0.40.50.90.8-0.70.5-0.60.60.71.00.7-0.7-0.61.0-0.80.7-0.6-0.2
Pavlov. Cond. change in total contacts0.40.50.70.6-0.70.7-0.70.70.70.80.7-0.7-0.60.8-0.80.7-0.70.4
Pavlov. Cond. index score1.51.92.91.3-1.41.4-1.41.31.41.71.4-1.4-1.21.7-1.51.4-1.30.1
Pavlov. Cond. latency score1.52.03.01.5-1.51.4-1.41.41.41.71.4-1.4-1.21.7-1.51.3-1.3-0.0
Pavlov. Cond. lever contacts1.01.21.81.2-1.21.2-1.11.11.01.31.0-1.1-1.01.3-1.11.0-1.00.1
Pavlov. Cond. magazine entry number0.50.61.1-0.70.7-0.70.7-0.7-0.8-1.1-0.80.80.6-1.10.9-0.80.70.2
Pavlov. Cond. intertrial magazine entries0.60.81.3-1.11.0-0.90.8-0.8-1.0-0.9-1.01.00.7-0.91.0-0.80.70.4
Pavlov. Cond. lever-magazine prob. diff.0.60.81.40.7-0.80.8-0.80.80.91.20.9-0.9-0.71.2-1.00.9-0.9-0.0
Pavlov. Cond. response bias1.01.21.91.0-1.11.1-1.11.11.11.41.1-1.1-1.01.4-1.21.1-1.10.2
Pavlov. Cond. lever latency0.40.61.00.6-0.71.0-0.80.80.81.00.8-0.8-0.91.0-0.80.6-0.6-0.4
Pavlov. Cond. magazine entry latency0.30.51.0-0.70.7-1.00.7-0.6-0.8-0.6-0.70.70.8-0.60.8-0.40.40.5
Pavlov. Cond. change in total contacts0.10.20.70.8-0.5-0.0-0.30.30.30.10.3-0.3-0.20.1-0.20.4-0.40.8
Pavlov. Cond. index score0.30.51.1-0.50.6-1.10.7-0.7-0.7-0.9-0.70.70.7-0.90.8-0.50.50.7
Pavlov. Cond. latency score0.40.61.1-0.60.7-1.10.7-0.7-0.8-0.9-0.80.80.8-0.90.9-0.50.50.6
Pavlov. Cond. lever contacts0.40.61.0-0.50.6-1.00.8-0.8-0.8-0.9-0.80.80.9-0.90.8-0.60.70.3
Pavlov. Cond. magazine entry number0.71.01.80.8-0.91.3-1.01.01.11.01.0-1.0-1.11.0-1.10.8-0.8-0.9
Pavlov. Cond. intertrial magazine entries0.20.40.80.5-0.60.6-0.50.50.70.90.7-0.7-0.40.9-0.80.6-0.5-0.1
Pavlov. Cond. lever-magazine prob. diff.0.30.40.9-0.40.5-0.90.6-0.5-0.6-0.7-0.60.60.6-0.80.7-0.30.30.8
Pavlov. Cond. response bias0.60.81.4-0.50.8-1.20.9-0.9-1.0-1.0-0.90.91.1-1.01.0-0.70.80.4
Time in closed arm before self-admin0.10.20.5-0.30.3-0.20.1-0.3-0.5-0.6-0.50.40.3-0.60.7-0.40.3-0.3
Time in closed arm after self-admin1.82.12.6-1.41.4-1.31.4-1.5-1.6-1.5-1.61.41.0-1.51.6-1.51.5-1.0
Time in open arm before self-admin0.10.10.50.7-0.40.2-0.10.10.30.40.3-0.20.10.4-0.50.10.0-0.3
Time in open arm after self-admin0.00.00.10.3-0.1-0.10.10.10.1-0.10.00.1-0.1-0.20.0-0.00.1-0.1
Bone: periosteal estimation0.10.30.50.40.1-0.40.5-0.5-0.4-0.7-0.40.40.6-0.70.5-0.60.6-0.6
Bone: periosteal perimeter0.00.10.20.3-0.0-0.10.2-0.2-0.1-0.4-0.10.10.3-0.40.3-0.30.3-0.4
Bone: post-yield work0.20.41.00.10.3-0.40.5-0.5-0.7-0.8-0.60.70.3-0.80.8-0.80.7-1.0
Progressive ratio test 1 active lever presses1.62.83.61.9-1.91.6-1.81.71.81.51.8-1.8-1.71.6-1.61.8-1.80.8
Progressive ratio test 1 breakpoint1.42.43.21.8-1.71.5-1.71.61.71.41.7-1.7-1.51.4-1.51.7-1.70.8
Progressive ratio test 1 inactive lever presses0.71.83.51.9-1.61.2-1.41.41.31.31.3-1.2-1.41.3-1.01.3-1.40.7
Progressive ratio test 2 active lever presses1.01.42.41.3-1.31.2-1.31.21.20.81.2-1.1-1.50.8-0.91.2-1.40.9
Progressive ratio test 2 breakpoint1.51.92.91.5-1.51.4-1.51.41.41.01.4-1.3-1.71.0-1.11.4-1.61.0
Progressive ratio test 2 inactive lever presses0.10.41.40.7-0.70.6-0.70.80.50.30.5-0.3-1.20.3-0.20.7-0.90.5
Incentive Sensitization - Responses0.00.10.50.2-0.10.1-0.20.10.0-0.3-0.00.2-0.7-0.40.10.1-0.30.5
Incentive Sensitization - Breakpoint0.00.10.60.2-0.20.2-0.20.20.1-0.20.00.1-0.8-0.20.00.2-0.30.5
Sum of active levers in priming session hrs 5-62.42.33.2-1.41.6-1.71.6-1.5-1.7-1.5-1.71.80.9-1.61.4-1.51.5-0.7
Progressive ratio0.20.71.10.5-0.60.5-0.70.70.90.90.9-0.8-1.00.9-1.00.9-0.90.8
Food seeking constrained by brief footshock0.70.81.51.1-1.00.9-0.90.91.00.70.9-0.8-1.20.8-1.10.8-0.80.5
Seeking ratio, punishment vs. effort0.00.10.20.4-0.10.10.1-0.0-0.3-0.5-0.30.20.1-0.40.3-0.40.4-0.5
Retroperitoneal fat weight0.73.14.11.6-1.81.8-1.81.71.92.01.9-2.0-2.01.8-1.91.7-1.60.5
Reaction time number correct1.86.58.2-2.22.5-2.42.6-2.6-2.5-2.9-2.62.62.7-2.82.6-2.72.7-1.5
Reaction time mean minus median0.10.51.0-0.30.6-0.90.8-0.8-0.7-0.7-0.70.61.0-0.70.8-0.70.8-0.3
Reaction time mean minus median AUC0.10.40.6-0.40.5-0.70.7-0.7-0.7-0.4-0.60.50.7-0.40.6-0.70.8-0.5
Reaction time num false alarms0.91.63.0-1.31.3-1.71.3-1.2-1.5-1.2-1.41.61.0-1.31.4-1.01.00.1
Reaction time num false alarms AUC0.10.30.8-0.70.5-0.90.4-0.4-0.6-0.4-0.60.70.1-0.50.6-0.10.10.6
Reaction time trials correct on left1.86.58.2-2.22.5-2.42.6-2.6-2.5-2.9-2.62.62.7-2.82.6-2.72.7-1.5
Reaction time trials on left1.75.77.3-2.02.3-2.22.4-2.4-2.4-2.7-2.42.42.5-2.72.4-2.52.5-1.4
Reaction time mean0.61.32.01.4-1.31.0-1.21.21.11.01.1-1.1-1.31.1-1.01.1-1.20.5
Reaction time mean AUC0.51.31.81.3-1.21.0-1.21.21.11.01.1-1.1-1.31.1-1.11.2-1.20.4
Median of all reaction times1.82.83.61.8-1.81.6-1.81.81.71.61.7-1.6-1.91.6-1.61.7-1.80.8
Reaction time omissions2.03.34.42.0-2.01.9-1.91.91.81.81.8-1.8-2.11.8-1.91.8-1.90.8
Reaction time false alarm rate0.30.41.10.2-0.40.1-0.60.60.40.70.5-0.3-0.90.6-0.40.9-0.91.0
Reaction time premature initiation rate2.03.13.91.4-1.71.8-1.81.81.82.01.8-1.8-1.91.9-1.91.8-1.81.0
Reaction time premature initiations0.10.30.50.4-0.50.7-0.60.50.60.60.6-0.6-0.60.6-0.60.5-0.50.3
Std. dev. reaction times0.00.10.30.6-0.40.0-0.20.20.20.10.2-0.2-0.50.1-0.10.3-0.20.2
Reaction time trials completed1.75.77.3-2.02.3-2.22.4-2.4-2.4-2.7-2.42.42.5-2.72.4-2.52.5-1.4
Reaction time trials AUC1.55.36.7-2.02.3-2.22.4-2.4-2.3-2.6-2.42.32.5-2.62.3-2.52.4-1.3
Run reversals in cocaine runway, females2.12.33.6-1.41.5-1.71.5-1.4-1.6-1.6-1.61.71.2-1.91.8-1.41.2-1.1
Run reversals in cocaine runway, males0.30.30.6-0.40.5-0.50.5-0.7-0.6-0.7-0.70.6-0.1-0.60.7-0.60.6-0.2
Latency to leave start box in cocaine runway6.99.511.1-2.93.2-3.33.3-3.3-3.2-2.8-3.23.33.3-3.03.2-3.23.2-1.4
Latency to leave start box in cocaine runway, F4.65.76.7-2.22.4-2.52.5-2.5-2.5-2.4-2.52.62.4-2.42.4-2.52.4-1.0
Latency to leave start box in cocaine runway, M3.93.86.1-1.92.0-2.22.1-2.1-2.0-1.5-2.02.02.5-1.72.0-1.92.0-0.8
Std. dev. time between licks in bursts0.10.10.40.1-0.30.2-0.40.40.40.00.4-0.3-0.50.10.10.5-0.50.6
Total sessions with >9 infusions5.66.98.22.7-2.82.7-2.92.82.72.52.7-2.7-2.42.5-2.62.8-2.91.2
Short access day 1 total inactive lever presses0.40.81.40.8-0.90.9-1.01.10.90.70.9-0.6-0.70.6-0.91.0-1.20.8
Short access day 10 total inactive lever presses0.42.84.1-1.81.8-2.01.7-1.6-1.9-1.6-1.91.91.4-1.81.7-1.61.5-0.3
Short access day 1 total infusions1.93.76.02.0-2.12.0-2.12.11.91.81.9-1.7-2.41.7-1.61.9-2.11.1
Short access day 10 total infusions3.45.77.22.6-2.72.5-2.72.72.52.22.5-2.5-1.42.2-2.42.5-2.60.7
Short access total infusions6.18.611.03.3-3.33.2-3.23.23.12.83.0-3.0-2.62.8-3.03.0-3.01.0
Short access day 1 locomotion1.22.03.01.7-1.61.3-1.51.41.41.51.4-1.3-1.31.5-1.21.4-1.40.9
Short access day 10 total locomotion0.00.10.3-0.4-0.00.2-0.10.10.40.40.4-0.50.60.4-0.30.4-0.20.3
Short access total locomotion1.52.33.31.3-1.51.5-1.61.61.71.51.8-1.8-0.71.6-1.51.7-1.60.9
One hour access (0.3 mA shock)0.10.10.60.0-0.1-0.1-0.10.2-0.00.2-0.0-0.1-0.80.2-0.10.2-0.30.3
Compulsive drug intake0.10.10.20.1-0.20.4-0.30.30.20.30.3-0.3-0.30.2-0.40.2-0.30.3
One hour access (shock baseline)0.00.10.40.3-0.30.1-0.30.30.20.40.2-0.2-0.60.4-0.10.3-0.30.2
Social response proportion3.14.06.11.7-1.91.8-1.81.81.92.42.0-2.1-2.32.4-2.52.0-1.80.9
Social responses1.82.44.11.2-1.41.4-1.41.41.61.81.5-1.7-1.71.9-2.01.6-1.40.9
Social time0.30.50.9-0.60.7-0.90.9-0.9-0.7-0.5-0.70.60.0-0.50.6-0.70.90.1
Soleus weight1.54.56.7-2.62.4-2.22.1-2.1-2.2-2.4-2.22.31.7-2.42.3-1.91.8-0.8
Bone: stiffness0.30.51.6-0.10.5-0.60.7-0.7-0.6-0.7-0.70.70.6-0.70.7-0.90.9-1.3
Tibialis anterior weight0.31.01.2-1.11.1-1.01.1-1.0-1.1-1.1-1.11.00.9-1.01.0-1.11.1-0.3
Time to tail flick, vehicle, before self-admin1.21.52.5-1.21.2-1.01.3-1.4-1.0-1.4-1.01.01.6-1.51.0-1.21.3-0.8
Time to tail flick, vehicle, after self-admin1.22.43.2-1.61.7-1.81.7-1.7-1.7-1.1-1.71.61.1-1.21.6-1.61.7-0.7
Time to tail flick, test, before self-admin0.30.30.5-0.60.6-0.60.6-0.5-0.5-0.7-0.60.70.4-0.70.6-0.60.6-0.3
Time to tail flick, test, after self-admin1.31.42.1-1.41.3-1.41.3-1.3-1.2-0.9-1.11.21.5-0.90.9-1.21.3-0.8
Delta time to tail flick, vehicle, before/after SA0.00.10.3-0.30.2-0.2-0.00.1-0.30.2-0.30.2-0.50.20.2-0.1-0.00.1
Delta time to tail flick, test, before/after SA0.00.10.2-0.20.1-0.20.2-0.2-0.00.3-0.0-0.00.50.3-0.2-0.10.2-0.3
Tibia length4.011.118.94.3-3.83.4-3.33.33.43.43.4-3.5-2.93.3-3.43.2-3.11.3
Ambulatory time before self-admin0.10.41.2-0.30.5-0.70.7-0.7-0.6-0.5-0.60.61.1-0.50.4-0.60.7-0.1
Ambulatory time after self-admin0.10.10.4-0.30.3-0.40.2-0.1-0.5-0.2-0.50.7-0.1-0.30.4-0.30.20.1
Bone: tissue strength0.30.30.40.6-0.60.7-0.60.70.60.30.6-0.6-0.60.3-0.50.5-0.6-0.2
Total heroin consumption0.50.61.0-1.00.9-0.80.8-0.8-0.9-0.6-1.01.0-0.2-0.60.5-0.70.7-0.3
Bone: trabecular number0.61.22.1-0.70.9-0.91.0-1.0-1.0-1.2-1.01.11.4-1.31.1-1.11.1-1.4
Bone: trabecular spacing0.71.01.21.1-1.01.1-1.01.00.91.00.9-1.0-1.11.1-0.90.9-0.91.0
Bone: trabecular thickness0.00.00.10.3-0.0-0.10.1-0.1-0.10.0-0.10.10.10.0-0.1-0.20.2-0.2
Bone: trabecular tissue density0.50.81.71.3-1.10.7-0.90.90.91.10.9-0.7-0.71.1-1.00.9-0.80.3
Water consumed over 24 hours0.10.31.4-1.20.7-0.80.5-0.5-0.4-0.3-0.40.40.3-0.40.4-0.10.20.4
Number of responses in last shaping day1.62.02.51.4-1.51.4-1.51.51.51.51.6-1.4-1.41.4-1.31.5-1.51.0