Hub : Genes

Josd1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc isoform ratio NM_001025009.1 0.02 0.01 5.9e-03 0.01 0 0 0.01 5.0e-03 9.7e-02 1.0e-01 3.0e-02
2 NAcc isoform ratio XM_039079268.2 0.02 0.01 5.9e-03 0.01 0 0 0.01 3.6e-03 6.6e-02 8.2e-02 2.4e-02
3 pVTA isoform ratio NM_001025009.1 0.05 0.03 2.1e-03 0.04 0.03 0.02 0.03 7.0e-04 2.8e-03 8.6e-03 2.5e-03
4 pVTA isoform ratio XM_039079268.2 0.05 0.03 2.2e-03 0.04 0.03 0.02 0.03 8.2e-04 3.0e-03 1.2e-02 3.1e-03
5 PL gene expression Josd1 0.23 0.08 0.0e+00 0.21 0.24 0.25 0.25 5.3e-23 2.0e-26 1.2e-26 4.9e-27
6 pVTA mRNA stability Josd1 0.05 0.02 9.0e-04 0.03 0.04 0.03 0.03 9.0e-04 5.6e-04 2.0e-03 2.1e-03
7 BLA gene expression Josd1 0.26 0.09 3.4e-14 0.22 0.23 0.24 0.24 1.1e-11 3.2e-12 4.0e-13 3.4e-13
8 NAcc alternative TSS XM_039079268.2 0.02 0.01 7.3e-03 0 0.01 0 0 6.0e-02 5.5e-03 6.9e-02 4.6e-02
9 NAcc gene expression Josd1 0.04 0.02 1.8e-05 0.04 0.03 0.03 0.04 5.0e-07 3.7e-05 2.2e-05 8.5e-07
10 PL isoform ratio XM_039079268.2 0.02 0.01 7.0e-03 0.01 0.01 0.01 0.01 2.8e-02 1.9e-02 3.8e-02 5.9e-02
11 PL isoform ratio NM_001025009.1 0.02 0.01 5.8e-03 0.01 0.01 0.01 0 2.8e-02 1.4e-02 4.1e-02 7.6e-02
12 Adipose mRNA stability Josd1 0.03 0.02 2.5e-03 0.01 0.02 0.01 0.01 1.6e-02 1.0e-03 8.5e-03 1.4e-02
13 Liver alternative TSS XM_039079268.2 0.02 0.02 4.3e-03 0.03 0.01 0 0.02 4.2e-04 8.9e-03 2.7e-01 5.8e-03
14 RMTg mRNA stability Josd1 0.15 0.09 8.4e-03 0.15 0.11 0.14 0.12 1.1e-04 6.5e-04 2.0e-04 5.1e-04
15 IC gene expression Josd1 0.17 0.08 1.1e-05 0.06 0.1 0.09 0.09 1.0e-03 6.5e-05 1.3e-04 1.7e-04
16 pVTA gene expression Josd1 0.04 0.02 5.5e-03 0.04 0.03 0.03 0.03 4.5e-04 1.1e-03 9.0e-04 8.7e-04
17 PL mRNA stability Josd1 0.06 0.03 1.2e-05 0.05 0.05 0.05 0.06 1.8e-06 5.0e-06 1.4e-06 3.2e-07
18 pVTA intron excision ratio chr7_113113700_113113817 0.04 0.03 4.3e-03 0.03 0.02 0.03 0.02 3.3e-03 6.9e-03 3.1e-03 1.9e-02
19 Brain mRNA stability Josd1 0.09 0.04 4.5e-06 0.06 0.07 0.06 0.04 3.2e-06 8.4e-07 3.9e-06 1.7e-04
20 OFC gene expression Josd1 0.22 0.11 4.4e-03 0.07 0.01 0.02 0.02 8.0e-03 1.5e-01 9.0e-02 1.0e-01
21 Brain gene expression Josd1 0.09 0.04 4.0e-07 0.04 0.06 0.06 0.06 6.9e-05 1.4e-06 3.3e-06 2.4e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
Bone: apparent density0.00.10.30.2-0.20.3-0.3-0.10.1-0.1-0.5-0.1-0.10.10.0-0.10.5-0.30.10.30.40.4-0.10.1
Area under the delay curve3.64.26.72.6-2.62.5-2.5-2.42.5-2.0-1.7-2.0-2.52.42.1-2.42.3-1.5-1.61.80.41.40.7-1.0
BMI with tail0.61.93.3-1.71.7-1.61.61.5-1.61.81.21.01.6-1.5-1.61.8-1.50.80.1-1.6-0.3-1.2-1.10.5
BMI without tail0.61.83.5-1.91.9-1.81.81.5-1.80.70.31.01.7-1.7-1.60.9-1.60.30.2-1.60.1-0.6-1.20.9
Body weight2.08.714.4-3.53.5-3.53.53.7-3.33.32.83.33.8-3.8-2.42.5-3.42.42.4-2.5-1.2-1.8-0.42.1
Weight adjusted by age0.40.61.6-1.01.0-0.90.90.7-1.1-0.10.80.60.6-0.6-0.90.3-1.31.01.0-0.90.3-0.6-0.4-0.1
Bone surface0.10.20.50.4-0.40.4-0.4-0.30.6-0.4-0.2-0.1-0.60.60.6-0.70.20.1-0.10.40.20.50.6-0.3
Bone volume0.00.10.30.2-0.20.3-0.3-0.20.2-0.1-0.3-0.2-0.20.30.1-0.10.2-0.3-0.10.10.60.10.0-0.2
Breakpoint value in progressive ratio session0.10.10.90.3-0.30.4-0.4-0.20.50.2-0.2-0.1-0.30.30.40.10.2-0.3-0.90.40.00.20.60.0
Number of licking bursts0.71.12.11.0-1.01.1-1.1-1.30.7-1.4-1.3-1.5-1.11.00.6-1.20.6-1.3-1.40.21.10.4-0.4-0.8
Context. condit. distance diff. score6.47.811.6-3.43.4-3.43.43.0-3.32.62.82.43.1-3.1-3.03.2-3.22.02.5-2.80.2-2.9-1.10.6
Locomotion velocity, session 10.60.62.10.4-0.40.3-0.30.10.6-0.00.80.5-0.20.21.2-1.2-0.11.31.30.5-1.50.91.30.7
Locomotion distance, session 14.15.29.42.7-2.72.7-2.7-2.82.6-2.9-1.9-2.5-3.02.92.3-3.11.7-1.3-1.81.20.71.60.4-1.5
Locomotion velocity, session 20.30.41.70.5-0.50.5-0.5-0.30.80.60.8-0.1-0.80.90.70.20.31.00.50.4-1.30.40.4-0.2
Locomotion distance, session 25.27.312.23.3-3.33.3-3.3-2.93.5-2.5-2.3-2.2-3.23.13.2-3.42.9-1.5-1.72.7-0.42.71.6-0.7
Locomotion velocity, session 32.12.45.4-1.81.8-1.91.91.4-2.00.21.40.91.3-1.2-2.11.2-2.21.00.7-2.31.0-2.1-1.5-0.7
Locomotion distance, session 31.61.87.30.1-0.10.1-0.1-0.9-0.5-2.0-0.9-1.5-0.70.7-1.0-0.2-0.9-1.5-1.7-1.82.7-1.5-1.9-2.2
Stereotopy head waving bouts, day 30.81.02.9-0.70.7-0.50.51.1-0.11.21.11.40.9-0.90.50.1-0.21.41.50.5-1.70.51.11.5
Stereotopy head waving duration, day 33.03.67.9-1.71.7-1.51.52.2-0.92.62.62.51.9-1.9-0.21.1-0.92.82.70.1-2.70.21.22.3
Locomotion velocity, session 70.50.61.9-0.60.6-0.60.60.4-0.91.31.10.30.9-0.9-0.71.4-0.90.70.5-0.70.4-0.8-0.10.4
Locomotion distance, session 70.20.31.30.4-0.40.3-0.3-0.2-0.00.60.20.10.5-0.60.5-0.1-0.10.10.90.40.20.31.11.0
Stereotopy head waving bouts, day 73.84.37.8-2.42.4-2.32.32.1-2.31.82.81.61.7-1.6-2.12.6-2.52.52.0-2.4-0.6-1.9-1.50.2
Stereotopy head waving duration, day 73.23.88.3-2.32.3-2.22.21.9-2.11.92.61.41.5-1.4-2.32.9-1.92.31.5-2.1-0.4-1.8-1.70.1
Locomotion velocity, session 81.72.15.6-1.11.1-1.21.21.6-0.72.12.21.91.2-1.2-0.21.0-1.62.41.7-0.7-2.1-0.30.81.1
Locomotion distance, session 80.40.61.5-1.01.0-1.01.00.8-0.80.41.00.60.6-0.6-1.00.7-0.81.01.2-0.90.1-0.7-0.4-0.1
Degree of sensitization distance3.33.311.0-0.60.6-0.70.71.6-0.43.01.72.21.9-2.00.51.00.22.03.11.5-2.51.22.43.3
Degree of sensitization stereotypy2.83.06.2-1.91.9-1.91.91.6-1.81.32.51.11.1-1.0-1.92.4-2.22.31.5-2.2-0.4-1.7-1.5-0.3
Conditioned locomotion0.50.61.3-0.70.7-0.60.60.9-0.81.01.00.90.9-0.9-0.40.8-0.71.11.1-0.4-0.5-0.10.20.9
Cocaine response after cond. corrected0.40.41.60.2-0.20.3-0.30.30.70.20.70.8-0.20.20.9-0.30.31.10.60.8-1.20.81.30.7
Cocaine response after cond. not corrected0.20.31.10.1-0.10.2-0.20.30.60.00.40.7-0.30.30.6-0.00.40.80.10.7-1.00.60.90.3
Cocaine response before conditioning0.40.51.7-0.10.1-0.00.0-0.5-0.2-0.4-0.8-0.8-0.40.4-0.70.40.2-1.1-1.3-0.51.0-0.6-1.2-1.1
Saline control response0.71.01.9-1.41.4-1.41.41.2-1.20.60.50.80.9-0.8-1.41.2-0.80.40.9-0.90.3-1.1-0.6-0.3
Bone: connectivity density0.10.10.5-0.20.2-0.20.20.4-0.20.50.10.50.4-0.5-0.00.0-0.20.30.70.1-0.00.30.50.6
Bone: cortical apparent density0.91.33.8-0.80.8-0.80.8-0.1-1.4-1.0-0.6-0.80.4-0.4-1.60.3-0.9-1.1-0.4-1.81.9-1.6-1.8-1.2
Bone: cortical area0.40.63.10.1-0.10.1-0.10.50.51.10.80.80.2-0.20.70.30.40.90.71.1-1.80.61.30.9
Bone: cortical porosity0.70.73.1-0.30.3-0.30.30.90.31.70.91.20.3-0.30.21.20.41.10.61.0-1.60.51.10.8
Bone: cortical porosity1.61.76.6-0.50.5-0.50.51.40.32.31.71.90.7-0.60.51.40.11.91.21.2-2.60.61.71.4
Bone: cortical thickness0.50.81.61.1-1.11.0-1.0-0.81.2-0.1-0.9-0.7-0.80.81.0-0.51.2-1.2-1.11.2-0.40.40.7-0.4
Bone: cortical thickness1.61.93.51.6-1.61.5-1.5-1.41.9-1.2-1.2-1.1-1.41.41.8-1.61.6-1.2-1.31.6-0.71.01.1-0.4
Bone: cortical tissue density0.91.23.4-0.80.8-0.80.8-0.0-1.4-0.9-0.5-0.70.5-0.5-1.50.3-1.0-1.0-0.4-1.81.8-1.6-1.7-1.2
Condit. Reinf. active minus inactive responses0.10.10.6-0.10.1-0.10.1-0.0-0.2-0.7-0.6-0.10.2-0.3-0.0-0.70.1-0.8-0.20.00.8-0.20.2-0.0
Condit. Reinf. active-inactive response ratio0.40.51.1-0.90.9-0.90.90.5-0.9-0.00.20.20.7-0.8-0.90.5-0.6-0.20.3-0.71.0-1.1-0.2-0.2
Condit. Reinf. active responses0.50.62.9-0.00.0-0.00.0-0.3-0.4-1.4-1.4-0.60.2-0.3-0.5-1.00.4-1.6-0.4-0.11.7-0.2-0.5-0.2
Condit. Reinf. inactive responses0.70.83.70.3-0.30.2-0.2-0.7-0.5-1.5-1.7-0.90.1-0.2-0.7-0.90.5-1.9-0.8-0.31.9-0.1-1.2-0.2
Incentive salience index mean0.20.31.30.1-0.10.1-0.1-0.2-0.2-1.0-1.0-0.40.2-0.3-0.0-0.80.3-1.1-0.40.20.90.10.10.1
Condit. Reinf. lever presses0.20.31.80.2-0.20.2-0.2-0.3-0.3-0.9-1.2-0.50.3-0.4-0.2-0.60.4-1.3-0.80.10.90.2-0.30.3
Condit. Reinf. active minus inactive responses0.81.13.01.2-1.21.1-1.1-0.71.5-0.8-0.2-0.2-0.90.81.7-1.50.6-0.1-0.41.2-1.01.01.70.2
Condit. Reinf. active-inactive response ratio0.50.63.00.6-0.60.5-0.5-0.00.9-0.20.30.5-0.20.11.3-1.00.30.50.31.0-1.30.91.70.8
Condit. Reinf. active responses0.50.72.50.9-0.90.8-0.8-0.41.3-0.10.40.1-0.80.71.5-0.80.20.4-0.20.9-1.20.61.60.1
Condit. Reinf. inactive responses0.20.30.70.7-0.70.7-0.7-0.60.90.20.2-0.5-0.80.70.9-0.00.0-0.0-0.60.3-0.4-0.10.5-0.5
Condit. Reinf. lever presses0.40.60.90.9-0.90.9-0.9-0.90.8-0.9-0.9-0.8-0.70.60.7-0.80.8-0.8-0.80.80.40.70.40.0
Condit. Reinf. lever reinforcers received0.50.72.90.9-0.90.8-0.8-0.31.3-0.00.40.2-0.60.61.5-0.80.40.50.11.1-1.30.81.70.5
Conditioned reinforcement - actives1.42.54.72.0-2.02.0-2.0-1.62.2-1.3-1.1-1.1-1.91.82.1-1.61.1-1.2-1.71.3-0.40.71.0-1.0
Conditioned reinforcement - inactives3.04.47.62.6-2.62.6-2.6-2.12.6-1.3-2.3-1.4-1.91.82.7-2.81.9-2.1-2.22.2-0.31.91.6-0.1
Conditioned locomotion1.31.74.81.4-1.41.4-1.4-0.52.1-0.1-0.40.2-1.11.12.2-1.01.5-0.2-1.02.0-1.71.51.80.4
Patch foraging indifference point 0 sec0.20.41.7-0.60.6-0.60.60.7-0.30.3-0.40.60.9-0.9-0.1-0.60.8-0.00.20.9-0.20.80.71.3
Patch foraging indifference point AUC1.62.45.21.9-1.91.9-1.9-1.81.6-1.9-1.5-1.4-1.61.51.8-2.31.3-1.4-1.41.20.41.00.4-0.6
Delay disc. indifference point, 0s delay0.30.31.30.1-0.1-0.10.10.30.50.60.00.50.1-0.10.40.41.00.1-0.21.1-0.80.51.00.6
Delay disc. indifference point, 16s delay4.04.47.02.6-2.62.6-2.6-2.52.5-2.3-1.8-2.1-2.62.62.2-2.42.1-1.4-1.21.70.41.50.5-1.1
Delay disc. indifference point, 2s delay5.66.211.53.1-3.13.0-3.0-2.93.3-2.1-1.7-2.5-3.43.42.4-1.42.8-1.7-2.72.2-0.31.20.6-2.0
Delay disc. indifference point, 24s delay0.70.85.01.1-1.11.1-1.1-0.90.8-0.8-0.3-0.7-0.80.71.3-2.20.3-0.00.20.50.20.80.5-0.0
Delay disc. indifference point, 4s delay2.12.23.71.9-1.91.8-1.8-1.51.9-1.4-1.0-1.2-1.81.81.6-1.81.8-0.7-1.11.60.01.20.8-0.6
Delay disc. indifference point, 8s delay2.52.96.62.1-2.11.9-1.9-2.11.7-1.7-2.0-1.8-1.71.61.6-2.61.8-1.8-1.51.30.91.20.3-0.5
Indifference point function ln k2.03.66.3-2.42.4-2.42.42.2-2.12.02.01.91.9-1.8-2.22.5-1.61.71.7-1.5-0.3-1.6-0.70.3
Indifference point function log k2.03.66.3-2.42.4-2.42.42.2-2.12.02.01.91.9-1.8-2.22.5-1.61.71.7-1.5-0.3-1.6-0.70.3
Patch foraging total patch changes 0 sec0.20.31.7-0.30.3-0.30.30.3-0.1-0.1-0.90.10.5-0.50.0-0.81.3-0.5-0.41.00.20.90.40.9
Patch foraging total patch changes 12 sec0.40.52.30.4-0.40.4-0.4-0.10.9-0.1-0.30.1-0.30.21.1-0.71.1-0.0-0.51.5-1.10.91.40.6
Patch foraging total patch changes 18 sec1.01.54.01.1-1.11.1-1.1-0.61.4-0.2-1.0-0.1-0.40.31.8-1.71.6-0.6-0.82.0-1.01.91.91.3
Patch foraging total patch changes 24 sec0.50.92.51.0-1.01.0-1.0-1.00.6-0.5-1.5-1.0-0.40.30.8-1.01.2-1.6-1.41.00.60.60.60.2
Patch foraging total patch changes 6 sec1.01.54.31.0-1.01.0-1.0-0.71.3-0.7-1.3-0.5-0.70.61.7-1.91.9-0.7-0.72.1-0.81.81.30.8
Patch foraging time to switch 0 sec0.20.41.70.5-0.50.4-0.4-0.10.81.00.6-0.0-0.50.60.60.60.20.80.40.5-1.30.80.70.4
Patch foraging water rate 0 sec0.30.62.3-1.01.0-0.80.80.9-1.1-0.2-0.40.81.4-1.5-0.5-0.7-0.0-0.20.3-0.00.40.20.11.3
Patch foraging water rate 12 sec0.10.31.0-0.70.7-0.60.60.5-0.9-0.4-0.50.10.6-0.6-1.00.20.3-0.4-0.2-0.30.8-0.3-0.7-0.1
Patch foraging water rate 18 sec0.20.40.9-0.70.7-0.60.60.8-0.9-0.6-0.30.70.9-0.9-0.5-0.40.10.20.7-0.0-0.10.40.10.8
Patch foraging water rate 24 sec2.02.95.1-2.22.2-2.22.22.2-2.01.21.42.12.2-2.1-1.71.1-1.11.51.7-0.9-0.4-0.7-0.21.2
Patch foraging water rate 6 sec0.60.92.2-1.11.1-0.90.90.6-1.5-0.8-0.80.11.0-1.0-1.50.2-0.7-0.9-0.3-1.21.5-0.9-1.2-0.3
Seeking ratio, delayed vs. immediate footshock0.30.41.20.4-0.40.4-0.4-0.70.1-1.0-0.6-1.0-0.60.7-0.1-0.40.5-0.3-0.6-0.11.00.3-1.1-0.5
Distance traveled before self-admin1.82.34.62.0-2.02.0-2.0-1.72.1-1.0-1.0-1.3-1.71.81.7-1.02.2-0.6-0.21.8-0.31.80.70.0
Distance traveled after self-admin0.81.03.80.6-0.60.5-0.50.10.80.0-0.30.80.1-0.21.4-1.30.70.40.81.4-1.41.91.81.8
Extensor digitorum longus weight0.52.14.31.1-1.11.1-1.1-1.61.2-1.8-2.1-1.9-1.81.90.4-0.81.9-1.7-1.70.70.80.9-1.2-1.4
Bone: elastic displacement0.40.51.4-0.70.7-0.70.70.8-0.70.50.90.80.7-0.7-0.40.1-0.61.21.2-0.3-0.7-0.00.10.6
Bone: elastic work1.52.07.3-0.60.6-0.60.61.5-0.01.71.91.90.9-0.90.50.40.02.42.11.0-2.70.91.71.9
Bone: endosteal estimation0.81.86.1-0.70.7-0.60.61.4-0.11.42.02.00.9-0.90.50.6-0.52.51.90.7-2.30.81.71.8
Bone: endosteal perimeter1.02.17.0-1.11.1-1.11.11.7-0.51.82.42.01.1-1.0-0.11.5-0.92.61.90.2-2.20.11.21.4
Epididymis fat weight2.58.615.8-3.33.3-3.33.33.5-2.94.03.43.33.5-3.4-2.43.7-3.22.52.2-2.0-1.4-2.60.21.4
Delta time in closed arm before/after self-admin0.60.61.50.9-0.90.9-0.9-0.61.0-0.3-0.5-0.3-0.70.71.0-0.51.1-0.8-1.21.0-0.50.10.5-0.4
Delta time in open arm before/after self-admin0.10.10.40.2-0.20.2-0.2-0.10.2-0.6-0.1-0.1-0.30.30.1-0.5-0.20.20.6-0.10.10.50.00.1
Diff in mean of infusions in LGA sessions0.10.20.5-0.10.1-0.10.10.4-0.10.30.50.60.5-0.50.3-0.1-0.60.40.50.1-0.00.00.70.6
Delay discount exponential model param3.84.26.6-2.62.6-2.52.52.4-2.42.01.82.12.5-2.5-2.12.5-2.21.51.7-1.7-0.5-1.4-0.61.1
Extinction: sum of active levers before priming0.80.92.61.2-1.21.2-1.2-0.81.6-0.20.2-0.5-1.31.31.4-0.10.70.1-0.81.1-0.60.51.1-0.4
Active lever presses in extinction session 60.10.10.30.1-0.10.1-0.10.10.30.30.40.3-0.20.20.30.40.00.40.10.30.20.10.50.0
Bone: final force0.71.05.80.4-0.40.3-0.30.50.90.81.01.0-0.00.01.2-0.00.61.30.81.4-2.41.11.81.2
Bone: final moment0.81.26.50.3-0.30.3-0.30.60.90.91.11.20.1-0.11.3-0.00.51.51.01.5-2.61.21.91.4
Food consumed during 24 hour testing period0.30.51.90.1-0.10.2-0.20.50.61.30.60.90.1-0.10.80.30.10.6-0.10.8-1.30.31.40.6
Glucose0.20.41.2-0.40.4-0.40.40.7-0.40.9-0.20.91.0-1.1-0.20.3-0.5-0.3-0.00.0-0.40.10.71.1
Heart weight2.64.08.9-1.71.7-1.61.62.5-1.42.82.62.72.2-2.2-0.51.2-1.42.93.0-0.3-2.40.11.22.4
Delay discount hyperbolic model param4.14.67.2-2.72.7-2.62.62.5-2.52.11.82.22.7-2.6-2.12.4-2.31.71.9-1.8-0.5-1.3-0.51.3
Intermittent access intake day 1-15 change0.10.20.6-0.20.2-0.20.20.0-0.2-0.4-0.6-0.2-0.10.1-0.4-0.2-0.5-0.6-0.7-0.70.4-0.3-0.8-0.5
Intermittent access intake escalation0.10.30.9-0.20.2-0.10.1-0.2-0.3-0.7-0.7-0.5-0.20.2-0.5-0.3-0.5-0.7-0.7-0.90.7-0.3-1.0-0.7
Intermittent access intake escalation 20.20.20.6-0.40.4-0.30.30.0-0.4-0.3-0.7-0.30.2-0.2-0.5-0.1-0.4-0.7-0.3-0.70.6-0.3-0.8-0.3
Intermitt. access day 1 inactive lever presses0.31.14.90.3-0.30.3-0.30.50.21.40.31.20.9-1.00.8-0.4-0.10.71.31.0-1.51.32.02.2
Intermitt. access day 15 inactive lever presses0.30.72.01.0-1.01.1-1.1-0.50.9-0.1-0.8-0.2-0.30.21.3-1.40.4-0.40.40.9-0.41.31.00.9
Intermitt. access escalation Index0.50.74.00.2-0.20.3-0.3-0.90.2-0.4-1.0-1.0-0.80.8-0.30.10.4-1.3-2.0-0.31.3-0.4-1.1-1.3
Intermittent access day 1 total infusions2.33.78.32.5-2.52.5-2.5-1.62.9-0.7-0.6-0.9-2.12.02.9-1.71.8-0.4-1.22.4-1.51.82.2-0.0
Intermittent access day 15 total infusions1.62.44.41.9-1.92.0-2.0-1.72.1-1.6-1.3-1.4-2.01.91.9-1.81.3-1.1-1.51.3-0.31.20.7-0.8
Intermittent access terminal intake (last 3 days)1.82.34.41.9-1.92.0-2.0-1.72.1-1.3-1.0-1.4-1.91.92.0-1.71.3-0.8-1.11.3-0.51.20.7-0.6
Intermittent access total infusions4.24.910.52.8-2.82.9-2.9-2.13.2-1.1-1.1-1.4-2.52.43.2-2.22.1-0.9-1.62.5-1.42.12.0-0.2
Intermittent access day 1 locomotion1.92.44.91.9-1.91.9-1.9-1.42.2-0.4-1.1-0.9-1.41.32.2-1.51.8-0.8-1.12.1-0.71.81.40.5
Intermittent access day 15 total locomotion0.40.82.41.1-1.11.2-1.2-0.61.30.4-0.4-0.3-0.60.51.5-0.80.5-0.4-0.51.1-1.01.01.30.5
Intermittent access total locomotion0.91.13.41.2-1.21.1-1.1-0.41.40.8-0.50.1-0.30.21.9-0.90.7-0.5-0.61.3-1.31.31.71.1
Intermittent access standard deviation0.91.85.91.2-1.21.1-1.10.11.60.5-0.20.9-0.20.11.9-0.91.20.30.72.0-2.42.02.31.7
Left kidney weight4.722.149.3-4.14.1-4.04.05.7-3.06.77.06.24.7-4.7-1.64.7-4.76.65.9-1.6-5.2-2.12.63.7
Right kidney weight6.529.655.4-5.15.1-5.15.16.9-3.87.47.47.46.0-6.0-2.15.2-5.26.96.6-1.8-5.6-2.32.94.7
Cocaine induced anxiety0.50.72.3-0.80.8-0.70.70.9-0.61.51.20.70.9-0.9-0.41.1-0.90.70.9-0.7-0.5-0.90.00.3
Post-drug Anxiety1.31.42.7-1.51.5-1.41.41.1-1.70.81.00.61.4-1.4-1.41.0-1.50.61.0-1.50.7-1.3-0.90.2
Baseline Anxiety0.40.52.20.3-0.30.3-0.3-0.70.1-1.5-1.0-0.8-0.60.6-0.0-0.90.4-0.7-0.70.01.10.2-0.6-0.6
Tail length0.62.24.5-1.91.9-1.91.91.6-2.10.40.11.42.0-2.1-1.60.2-2.00.21.2-1.60.7-0.7-0.81.0
Length with tail1.77.312.1-3.23.2-3.23.23.5-3.12.22.43.33.4-3.5-2.31.7-3.32.23.1-2.2-0.7-1.7-0.11.7
Length without tail2.27.014.0-2.52.5-2.52.53.5-2.03.53.53.73.1-3.1-1.02.0-1.93.43.5-0.6-2.6-0.91.42.5
Times rat made contact with spout0.30.32.10.2-0.20.2-0.2-0.3-0.1-0.5-1.1-0.30.2-0.40.2-0.8-0.2-1.5-1.0-0.21.1-0.3-0.1-0.2
Lifetime Intake4.45.412.33.0-3.03.0-3.0-2.13.5-0.7-0.9-1.2-2.52.43.5-2.02.4-0.7-1.52.9-1.82.12.50.0
Liver weight, left0.81.43.9-1.31.3-1.21.21.0-1.30.81.20.60.9-0.8-1.41.7-1.60.50.2-1.80.6-2.0-0.9-0.8
Liver weight, right5.29.116.0-3.73.7-3.63.63.1-3.82.42.62.23.1-3.0-3.73.4-4.01.51.2-3.80.8-3.6-2.2-0.2
Locomotor activity1.42.14.6-1.71.7-1.81.82.1-1.21.71.62.11.5-1.4-0.91.4-1.31.51.1-0.6-1.4-1.00.30.6
Locomotor testing distance0.10.20.5-0.40.4-0.50.50.3-0.30.0-0.50.10.1-0.1-0.40.1-0.1-0.7-0.7-0.30.3-0.5-0.5-0.5
Locomotor testing rearing0.40.92.6-1.01.0-1.01.01.3-0.41.61.21.10.8-0.7-0.41.5-0.40.90.6-0.1-1.1-0.70.40.2
Locomotion in novel chamber1.31.66.5-0.00.00.1-0.1-1.0-0.6-1.7-1.5-1.4-0.60.6-1.2-0.2-0.3-1.8-1.4-1.42.6-0.9-2.2-1.8
Locomotion in novel chamber post-restriction0.91.54.40.9-0.90.9-0.9-1.50.8-1.4-1.4-1.8-1.51.50.2-0.31.1-1.7-2.10.41.2-0.2-0.9-1.7
Fecal boli incidents, locomotor time 10.81.23.41.1-1.11.1-1.1-0.41.1-0.2-0.50.2-0.30.21.7-1.21.10.10.21.6-1.21.91.61.4
Change in fecal boli incidents, locomotor task1.71.74.7-1.61.6-1.51.51.3-1.60.51.31.01.0-1.0-1.31.0-2.20.80.4-2.0-0.1-1.9-1.0-0.7
Time >=10cm from walls, locomotor time 10.80.92.3-0.70.7-0.60.61.1-0.11.01.11.50.8-0.90.4-0.1-0.41.41.10.5-1.50.41.31.3
Bouts of movement, locomotor time 10.40.40.9-0.60.6-0.60.60.7-0.60.90.90.60.7-0.7-0.31.0-0.80.40.1-0.50.4-0.90.20.0
Total resting periods, locomotor time 10.10.20.7-0.20.2-0.20.20.5-0.10.80.60.60.4-0.50.20.3-0.30.50.20.10.1-0.20.70.5
Rest time, locomotor task time 10.50.62.30.1-0.10.1-0.10.5-0.11.50.60.80.8-0.90.60.5-0.20.60.70.6-0.90.51.31.4
Distance moved, locomotor task time 10.50.71.8-1.21.2-1.31.30.7-1.00.00.70.40.5-0.5-1.30.5-0.70.50.4-1.10.1-1.1-1.1-0.5
Vertical activity count, locomotor time 10.51.22.7-1.51.5-1.61.61.2-1.50.70.11.11.6-1.7-1.20.3-1.0-0.10.3-1.00.3-0.8-0.60.6
Time >=10cm from walls, locomotor time 20.40.52.0-0.60.6-0.50.50.8-0.80.70.50.91.0-1.0-0.2-0.2-0.70.90.9-0.3-0.50.60.31.4
Bouts of movement, locomotor time 20.50.84.40.5-0.50.5-0.5-0.90.80.3-0.4-1.1-1.11.10.11.20.5-1.1-2.1-0.10.6-0.8-0.7-1.6
Total resting periods, locomotor time 20.61.15.10.9-0.90.9-0.9-1.21.30.0-0.6-1.3-1.51.50.60.80.8-1.1-2.20.40.3-0.4-0.3-1.5
Rest time, locomotor task time 20.40.51.30.9-0.90.9-0.9-0.40.8-0.0-0.3-0.3-0.50.41.0-0.90.4-0.2-0.30.7-1.10.70.90.2
Distance moved, locomotor task time 21.01.12.2-1.41.4-1.51.51.2-1.40.60.91.01.2-1.2-1.31.0-0.80.81.1-0.80.0-0.8-0.50.5
Vertical activity count, locomotor time 20.91.32.8-1.41.4-1.51.51.3-1.31.10.51.31.6-1.7-0.91.0-1.20.40.5-0.9-0.6-0.5-0.11.1
Light reinforcement 10.10.21.00.1-0.10.2-0.2-0.10.5-0.1-0.1-0.2-0.30.40.4-0.31.00.1-0.20.8-0.50.60.30.1
Light reinforcement 20.40.72.9-0.90.9-0.80.80.7-0.70.90.90.20.4-0.3-1.01.7-0.60.50.1-0.90.0-1.1-1.0-0.5
Bone: marrow area0.91.96.5-0.70.7-0.70.71.5-0.11.42.02.10.9-0.90.50.6-0.52.61.90.7-2.40.81.81.8
Bone: maximum diameter1.62.99.7-1.01.0-1.01.01.9-0.22.22.52.41.3-1.30.41.2-0.62.82.20.8-3.10.42.12.0
Bone: maximum force0.91.78.30.5-0.50.4-0.40.61.21.21.11.30.0-0.11.7-0.20.61.51.01.8-2.91.42.31.6
Bone: maximum moment1.11.99.20.4-0.40.4-0.40.71.11.31.31.50.2-0.21.7-0.10.51.71.21.8-3.01.42.51.8
Mean time between licks in bursts0.40.92.70.9-0.90.9-0.9-1.30.9-1.2-0.6-1.2-1.51.70.3-0.71.4-0.0-0.60.50.40.8-0.4-0.9
Mean num. licks in bursts0.60.91.8-1.11.1-1.21.21.2-1.01.10.81.31.3-1.3-0.70.9-1.10.30.8-0.7-0.1-1.00.10.5
Cd content in liver0.40.51.7-0.90.9-0.90.90.7-0.5-0.00.60.50.2-0.2-0.5-0.2-0.90.2-0.4-0.9-0.3-1.3-0.2-1.1
Co content in liver0.80.92.20.9-0.90.9-0.9-0.81.2-0.8-1.2-0.5-0.90.91.2-1.51.2-0.9-1.01.00.21.10.7-0.1
Cu content in liver3.74.410.52.0-2.02.0-2.0-2.71.5-3.2-3.1-2.8-2.12.10.9-2.41.9-2.7-2.20.71.81.5-1.0-1.1
Fe content in liver3.34.08.8-2.02.0-2.02.02.6-1.22.02.33.02.0-1.9-0.61.1-1.32.92.8-0.3-2.60.41.22.3
K content in liver0.20.20.60.5-0.50.5-0.5-0.60.2-0.8-0.6-0.6-0.40.40.1-0.2-0.1-0.50.1-0.20.70.4-0.4-0.1
Mg content in liver0.20.20.40.6-0.60.6-0.6-0.50.4-0.6-0.5-0.5-0.30.30.4-0.3-0.2-0.40.2-0.20.10.6-0.10.3
Mn content in liver0.30.31.40.2-0.20.2-0.2-0.5-0.0-0.4-0.2-0.7-0.50.5-0.30.5-0.2-0.7-0.7-0.70.4-0.9-0.8-1.2
Na content in liver0.10.10.60.0-0.00.0-0.0-0.2-0.2-0.8-0.7-0.20.2-0.2-0.1-0.4-0.3-0.40.4-0.4-0.00.6-0.40.5
Rb content in liver0.60.71.61.0-1.01.0-1.0-0.81.1-0.7-0.4-0.4-0.70.61.3-0.71.2-0.1-0.11.1-0.41.20.80.5
Se content in liver0.80.93.8-0.70.7-0.70.7-0.0-0.7-1.4-0.5-0.7-0.30.4-1.30.1-0.5-0.6-0.7-1.60.5-1.2-1.9-1.7
Sr content in liver3.32.97.81.2-1.21.2-1.2-2.10.6-2.3-2.6-2.5-1.41.4-0.0-1.21.0-2.8-2.4-0.22.3-0.0-1.6-1.7
Zn content in liver0.20.20.9-0.00.0-0.00.0-0.1-0.2-0.5-0.4-0.3-0.10.1-0.2-0.8-0.5-0.5-0.2-0.61.0-0.3-0.6-0.5
Bone: minimum diameter0.30.62.60.0-0.00.0-0.00.60.51.30.91.00.3-0.30.70.50.20.90.61.0-1.50.51.60.9
Time in familiar zone, hab. session 10.30.20.70.6-0.60.6-0.6-0.50.5-0.30.1-0.4-0.50.40.8-0.60.00.3-0.10.3-0.30.60.90.2
Time in novel zone, hab. session 11.11.12.1-1.41.4-1.41.41.5-1.01.30.91.41.1-1.1-1.01.0-0.70.90.7-0.7-0.8-0.6-0.60.5
Total zone transitions, hab. session 11.82.59.40.7-0.70.8-0.8-1.60.3-3.1-1.8-2.1-1.61.6-0.3-1.80.1-1.9-1.4-1.02.5-0.6-1.7-2.5
Total locomotion distance, hab. session 10.81.14.6-0.30.3-0.30.3-0.5-0.5-1.7-0.9-1.1-0.60.6-0.9-0.8-0.8-1.2-0.6-1.42.1-1.2-1.3-1.9
Locomotion velocity, hab. session 10.91.25.00.2-0.20.2-0.2-0.9-0.0-2.1-1.3-1.4-0.90.9-0.4-1.4-0.3-1.4-0.6-0.92.2-0.7-1.1-1.8
Time in familiar zone, hab. session 20.60.72.9-0.30.3-0.40.4-0.3-0.8-0.6-0.3-0.8-0.10.1-1.10.4-0.6-0.6-0.8-1.21.7-1.0-1.4-1.1
Time in novel zone, hab. session 20.50.52.20.3-0.30.3-0.30.40.80.5-0.00.90.1-0.11.0-0.40.50.10.41.2-1.50.81.50.8
Total zone transitions, hab. session 21.31.74.91.5-1.51.5-1.5-1.31.4-1.9-1.3-1.0-1.21.11.6-2.21.1-0.8-0.41.1-0.01.40.9-0.0
Total locomotion distance, hab. session 21.21.63.71.4-1.41.4-1.4-1.11.6-1.2-1.1-0.7-1.31.21.6-1.91.5-0.4-0.11.6-0.61.71.30.2
Locomotion velocity, hab. session 21.52.15.01.6-1.61.6-1.6-1.31.7-1.5-1.3-1.0-1.41.31.8-2.21.7-0.6-0.21.7-0.32.01.30.3
Novel to familiar place preference ratio2.52.75.2-2.32.3-2.32.32.0-1.70.81.51.61.6-1.5-1.61.3-2.11.31.5-1.8-0.6-1.5-0.60.0
Novelty place preference3.43.76.9-2.62.6-2.62.62.3-2.11.01.81.81.8-1.8-1.91.6-2.61.41.6-2.2-0.5-2.0-0.9-0.1
Time in novel zone, NPP test4.04.38.0-2.82.8-2.82.82.5-2.31.01.91.92.0-1.9-2.11.7-2.81.41.6-2.4-0.4-2.2-1.0-0.1
Total zone transitions, NPP test1.92.710.01.5-1.51.6-1.6-2.01.1-3.2-2.0-2.0-1.91.80.8-2.40.7-1.7-1.1-0.11.80.4-0.7-1.8
Total locomotion distance, NPP test0.81.03.51.1-1.11.1-1.1-1.11.0-1.7-1.0-1.0-1.21.21.0-1.90.7-0.5-0.10.60.60.90.4-0.5
Locomotion velocity, NPP test1.21.73.61.4-1.41.5-1.5-1.61.2-1.9-1.3-1.5-1.61.51.0-1.91.2-0.9-0.60.81.01.00.2-0.8
Intraocular pressure0.40.51.9-0.50.5-0.50.50.7-0.41.41.30.70.5-0.5-0.21.1-0.91.10.6-0.4-0.9-0.60.60.2
Delta distance traveled before/after self-admin2.52.76.0-1.91.9-1.91.92.2-1.61.51.32.52.2-2.3-0.70.3-1.91.41.6-0.8-1.1-0.40.81.7
Delta ambulatory time before/after self-admin1.82.25.7-1.61.6-1.61.62.1-1.21.11.42.41.9-2.0-0.3-0.0-1.71.61.6-0.5-1.3-0.11.11.6
Parametrial fat weight1.22.86.2-2.12.1-2.12.11.6-2.50.80.40.92.0-2.0-2.31.7-1.7-0.00.2-2.01.2-1.7-1.70.1
Pavlov. Cond. lever latency0.10.10.9-0.30.3-0.40.40.4-0.20.30.50.30.2-0.2-0.10.3-0.40.50.9-0.2-0.1-0.3-0.10.1
Pavlov. Cond. magazine entry latency1.51.93.21.7-1.71.8-1.8-1.61.7-1.2-1.2-1.3-1.71.71.4-1.11.4-0.9-1.81.2-0.31.20.6-0.6
Pavlov. Cond. change in total contacts2.83.04.82.2-2.22.2-2.2-1.92.1-1.4-1.6-1.5-1.91.91.9-1.52.0-1.3-1.91.8-0.11.61.0-0.4
Pavlov. Cond. index score0.70.91.81.2-1.21.2-1.2-0.91.1-0.5-0.8-0.6-0.90.91.1-0.81.0-0.6-1.31.1-0.41.00.80.0
Pavlov. Cond. latency score0.40.51.40.8-0.80.9-0.9-0.60.8-0.3-0.6-0.4-0.60.60.7-0.70.8-0.5-1.20.8-0.30.80.60.0
Pavlov. Cond. lever contacts0.70.82.01.0-1.01.1-1.1-1.00.7-0.8-1.2-0.8-0.70.70.6-0.81.1-1.0-1.40.80.40.80.3-0.0
Pavlov. Cond. magazine entry number1.72.13.6-1.81.8-1.91.91.7-1.61.31.31.61.7-1.6-1.41.2-1.41.21.8-1.2-0.2-1.1-0.50.6
Pavlov. Cond. intertrial magazine entries0.20.31.5-0.00.0-0.10.10.0-0.2-0.9-0.90.20.4-0.40.1-1.20.3-0.70.40.30.60.40.30.5
Pavlov. Cond. lever-magazine prob. diff.0.80.92.21.2-1.21.3-1.3-1.11.1-0.6-0.9-0.9-1.01.01.0-0.81.0-0.7-1.50.9-0.10.80.6-0.2
Pavlov. Cond. response bias1.41.73.11.7-1.71.8-1.8-1.51.4-1.0-1.2-1.3-1.31.31.3-1.11.4-1.1-1.61.2-0.01.10.6-0.3
Pavlov. Cond. lever latency0.20.21.5-0.20.2-0.30.3-0.0-0.0-0.00.4-0.2-0.30.4-0.20.3-0.7-0.1-0.3-0.8-0.0-1.1-0.3-1.2
Pavlov. Cond. magazine entry latency1.72.03.91.5-1.51.6-1.6-1.21.5-1.4-1.8-0.8-1.00.91.6-2.02.0-1.3-0.61.80.01.91.00.6
Pavlov. Cond. change in total contacts1.42.29.10.1-0.10.1-0.10.90.41.10.71.71.0-1.01.3-0.80.81.61.82.0-2.62.32.43.0
Pavlov. Cond. index score0.60.82.80.8-0.80.9-0.9-0.40.7-0.6-0.9-0.0-0.10.01.0-1.21.2-0.30.41.4-0.31.70.91.3
Pavlov. Cond. latency score0.71.03.30.9-0.91.0-1.0-0.60.8-0.8-1.1-0.2-0.20.11.1-1.41.4-0.50.31.5-0.21.80.91.3
Pavlov. Cond. lever contacts0.20.21.50.1-0.10.2-0.20.1-0.1-0.0-0.40.20.4-0.40.1-0.20.7-0.00.40.70.11.10.21.2
Pavlov. Cond. magazine entry number0.40.51.5-0.60.6-0.70.70.4-0.50.80.80.10.1-0.1-0.71.2-1.00.4-0.3-1.00.2-1.2-0.5-0.9
Pavlov. Cond. intertrial magazine entries0.10.21.30.3-0.30.2-0.20.00.11.10.50.30.3-0.40.50.4-0.40.10.20.3-0.5-0.10.90.6
Pavlov. Cond. lever-magazine prob. diff.0.50.72.60.7-0.70.8-0.8-0.40.6-0.5-0.9-0.0-0.10.00.9-1.11.3-0.30.31.4-0.31.60.71.2
Pavlov. Cond. response bias0.50.62.60.7-0.70.8-0.8-0.30.7-0.2-0.60.0-0.10.10.9-0.71.1-0.10.31.3-0.41.60.81.3
Time in closed arm before self-admin0.60.72.50.8-0.80.8-0.8-0.70.5-0.5-1.6-0.5-0.40.40.4-1.11.6-1.00.21.10.21.5-0.10.6
Time in closed arm after self-admin0.20.21.0-0.00.0-0.00.00.3-0.21.0-0.30.60.7-0.80.2-0.10.4-0.5-0.00.6-0.40.20.50.8
Time in open arm before self-admin0.20.30.8-0.50.5-0.50.50.1-0.8-0.20.2-0.20.4-0.4-0.70.3-0.70.0-0.0-0.90.3-0.8-0.8-0.4
Time in open arm after self-admin0.40.41.7-0.20.2-0.30.3-0.2-0.5-1.0-0.3-0.6-0.30.3-0.8-0.0-0.6-0.4-0.5-1.21.1-0.6-1.3-0.9
Bone: periosteal estimation0.81.76.7-0.40.4-0.40.41.20.21.61.81.80.7-0.70.70.6-0.12.21.71.1-2.60.81.91.7
Bone: periosteal perimeter1.83.18.1-1.31.3-1.31.32.1-0.62.32.72.51.5-1.5-0.01.5-1.02.82.30.4-2.90.11.71.8
Bone: post-yield work0.71.13.81.1-1.11.1-1.1-0.71.6-0.2-0.1-0.2-0.90.82.0-1.50.60.3-0.21.1-1.41.41.30.5
Progressive ratio test 1 active lever presses2.93.68.02.4-2.42.4-2.4-1.72.8-1.0-0.8-0.9-2.12.02.8-1.82.0-0.5-1.22.4-1.41.91.8-0.0
Progressive ratio test 1 breakpoint2.83.47.32.3-2.32.4-2.4-1.72.7-1.0-0.8-0.9-2.02.02.7-1.81.9-0.5-1.22.2-1.21.81.6-0.1
Progressive ratio test 1 inactive lever presses3.65.111.12.8-2.82.8-2.8-2.13.1-0.4-1.2-1.2-1.91.93.1-1.82.7-0.7-0.93.3-1.62.82.70.9
Progressive ratio test 2 active lever presses2.83.36.92.4-2.42.4-2.4-1.92.6-0.8-1.2-1.2-2.01.92.6-1.71.4-1.3-1.81.8-0.71.21.7-0.5
Progressive ratio test 2 breakpoint3.23.77.42.5-2.52.6-2.6-2.02.7-1.0-1.2-1.4-2.22.12.7-1.71.5-1.3-1.91.9-0.71.21.6-0.7
Progressive ratio test 2 inactive lever presses2.54.07.02.6-2.62.6-2.6-2.52.3-1.5-2.1-2.1-2.22.02.1-2.01.3-2.2-2.21.30.41.20.7-0.9
Incentive Sensitization - Responses0.50.71.81.0-1.01.0-1.0-1.00.8-0.6-0.9-0.9-0.90.80.7-0.50.1-1.1-1.30.20.5-0.10.3-0.9
Incentive Sensitization - Breakpoint0.50.61.61.0-1.01.0-1.0-0.90.8-0.4-0.8-0.8-0.80.80.8-0.40.1-1.1-1.30.20.4-0.10.4-0.8
Sum of active levers in priming session hrs 5-60.00.00.1-0.30.3-0.30.30.3-0.2-0.00.10.10.2-0.2-0.20.0-0.30.10.2-0.20.00.00.20.2
Progressive ratio0.10.20.70.3-0.30.3-0.30.10.40.3-0.10.4-0.00.00.6-0.60.20.20.10.5-0.30.80.40.7
Food seeking constrained by brief footshock0.20.30.80.5-0.50.5-0.5-0.30.80.40.30.1-0.60.60.7-0.10.60.1-0.80.6-0.90.00.2-0.4
Seeking ratio, punishment vs. effort0.10.10.50.3-0.30.3-0.3-0.30.40.20.2-0.1-0.30.30.30.30.5-0.0-0.40.5-0.7-0.20.4-0.3
Retroperitoneal fat weight2.912.623.9-3.93.9-3.93.94.4-3.34.84.44.23.9-3.9-2.74.9-3.33.42.6-2.3-2.1-3.00.21.6
Reaction time number correct0.61.24.00.2-0.20.1-0.1-0.8-0.5-1.1-0.5-1.4-0.70.8-1.00.6-0.7-1.0-1.2-1.51.8-1.4-1.8-2.0
Reaction time mean minus median0.00.00.4-0.10.1-0.10.10.2-0.0-0.10.10.30.1-0.10.00.1-0.10.20.6-0.0-0.30.30.20.3
Reaction time mean minus median AUC0.20.51.0-0.70.7-0.70.70.8-0.70.80.60.80.9-0.9-0.61.0-0.80.50.8-0.5-0.3-0.40.10.5
Reaction time num false alarms0.20.30.8-0.90.9-0.80.80.7-0.50.3-0.00.70.4-0.4-0.70.3-0.5-0.00.3-0.60.0-0.4-0.5-0.2
Reaction time num false alarms AUC0.20.30.8-0.90.9-0.80.80.6-0.50.1-0.00.50.3-0.3-0.70.4-0.4-0.10.2-0.70.2-0.6-0.7-0.5
Reaction time trials correct on left0.61.24.00.2-0.20.1-0.1-0.8-0.5-1.1-0.5-1.4-0.70.8-1.00.6-0.7-1.0-1.2-1.51.8-1.4-1.8-2.0
Reaction time trials on left0.71.34.40.3-0.30.2-0.2-0.9-0.4-1.2-0.6-1.4-0.80.9-1.00.6-0.7-1.1-1.4-1.51.9-1.4-1.8-2.1
Reaction time mean0.10.21.7-0.30.3-0.30.30.4-0.30.00.30.40.5-0.5-0.20.1-0.50.61.3-0.1-0.40.4-0.00.8
Reaction time mean AUC0.10.11.1-0.20.2-0.20.20.3-0.3-0.10.30.20.4-0.4-0.20.1-0.50.41.1-0.2-0.20.2-0.10.6
Median of all reaction times0.10.21.5-0.10.1-0.20.20.2-0.2-0.20.30.20.4-0.3-0.2-0.0-0.40.61.2-0.1-0.40.5-0.10.7
Reaction time omissions1.11.74.31.5-1.51.5-1.5-1.51.6-1.3-1.0-1.5-2.02.10.9-0.60.6-0.9-1.60.30.60.4-0.1-1.7
Reaction time false alarm rate0.20.30.9-0.90.9-0.80.80.9-0.30.50.11.00.6-0.6-0.40.2-0.10.20.7-0.1-0.4-0.10.00.3
Reaction time premature initiation rate0.91.26.00.6-0.60.6-0.60.41.01.00.11.00.1-0.11.4-0.50.70.60.21.8-1.71.72.41.5
Reaction time premature initiations0.20.32.30.5-0.50.5-0.50.10.60.7-0.10.5-0.10.00.7-0.10.10.2-0.30.8-0.70.71.50.6
Std. dev. reaction times0.30.51.0-0.70.7-0.70.71.0-0.70.60.61.00.9-0.9-0.50.5-1.00.71.0-0.5-0.5-0.20.10.7
Reaction time trials completed0.71.34.40.3-0.30.2-0.2-0.9-0.4-1.2-0.6-1.4-0.80.9-1.00.6-0.7-1.1-1.4-1.51.9-1.4-1.8-2.1
Reaction time trials AUC0.51.03.50.1-0.1-0.00.0-0.7-0.5-0.8-0.3-1.1-0.60.6-1.00.8-0.8-0.8-1.1-1.51.6-1.4-1.6-1.9
Run reversals in cocaine runway, females0.60.61.4-0.90.9-0.80.80.4-1.20.50.3-0.10.8-0.8-1.10.5-1.20.20.9-1.20.6-0.7-0.4-0.0
Run reversals in cocaine runway, males0.30.31.9-0.40.4-0.40.40.4-0.1-0.40.90.40.2-0.20.2-0.4-0.60.91.4-0.1-0.3-0.50.3-0.0
Latency to leave start box in cocaine runway0.30.31.8-0.20.2-0.30.30.3-0.30.31.30.3-0.00.1-0.51.2-0.11.30.6-0.3-0.4-0.4-0.3-0.2
Latency to leave start box in cocaine runway, F0.20.31.00.4-0.40.4-0.4-0.40.5-0.50.6-0.3-0.80.80.30.00.81.00.10.5-0.50.5-0.0-0.2
Latency to leave start box in cocaine runway, M1.41.33.9-1.11.1-1.11.11.1-1.21.31.30.91.0-0.9-1.32.0-1.60.90.8-1.3-0.0-1.4-0.6-0.2
Std. dev. time between licks in bursts0.30.41.70.7-0.70.6-0.6-0.40.5-0.7-0.5-0.1-0.40.40.6-1.01.00.20.20.90.21.30.40.6
Total sessions with >9 infusions1.82.26.11.5-1.51.6-1.6-0.42.11.00.70.4-0.90.82.4-0.31.30.8-0.22.3-2.31.42.51.1
Short access day 1 total inactive lever presses2.63.49.41.1-1.11.0-1.00.21.60.50.21.20.1-0.22.6-2.21.81.21.82.9-2.73.13.13.0
Short access day 10 total inactive lever presses0.61.64.5-0.90.9-1.01.01.2-1.31.80.81.42.0-2.1-0.50.3-1.40.71.9-0.4-0.6-0.10.82.0
Short access day 1 total infusions1.01.33.61.2-1.21.3-1.3-0.31.40.70.10.4-0.30.21.8-0.71.10.40.51.8-1.31.71.91.5
Short access day 10 total infusions1.51.94.91.5-1.51.5-1.5-0.62.00.50.40.1-1.01.02.2-0.51.40.5-0.22.2-2.21.52.20.8
Short access total infusions2.73.49.02.2-2.22.3-2.3-1.12.80.50.1-0.1-1.41.43.0-0.91.90.3-0.42.9-2.32.02.70.9
Short access day 1 locomotion0.60.72.40.6-0.60.6-0.60.10.80.5-0.00.60.1-0.11.2-0.60.80.40.41.3-1.31.51.31.6
Short access day 10 total locomotion0.81.44.31.3-1.31.2-1.2-0.41.10.5-1.30.30.1-0.21.4-0.71.3-0.9-0.31.9-0.52.11.81.9
Short access total locomotion1.11.34.21.0-1.01.0-1.0-0.11.40.8-0.30.5-0.10.11.6-0.41.4-0.0-0.32.0-1.51.71.91.6
One hour access (0.3 mA shock)6.17.110.93.2-3.23.3-3.3-3.13.2-2.4-2.4-2.7-3.23.12.7-2.42.8-2.4-3.22.10.21.50.6-1.6
Compulsive drug intake0.50.61.60.7-0.70.7-0.7-0.80.1-1.0-0.9-1.0-0.50.40.2-1.2-0.2-1.2-0.9-0.61.3-0.4-0.4-0.8
One hour access (shock baseline)1.62.44.61.8-1.81.9-1.9-1.72.1-1.1-1.0-1.4-1.92.01.6-0.92.1-0.9-1.61.8-0.61.20.6-0.6
Social response proportion0.50.52.70.3-0.30.4-0.40.40.80.30.60.5-0.60.70.4-0.11.01.40.41.0-1.61.20.50.4
Social responses0.81.03.11.1-1.11.1-1.1-0.51.3-0.7-0.4-0.4-1.21.21.2-0.71.80.1-0.71.6-0.91.10.9-0.3
Social time2.53.57.02.1-2.12.1-2.1-1.82.2-1.8-2.0-1.4-2.02.01.9-1.92.6-1.4-2.02.2-0.22.00.9-0.4
Soleus weight0.20.72.40.9-0.91.0-1.0-0.50.5-0.4-1.5-0.10.1-0.21.0-1.20.4-1.5-0.90.80.10.71.00.5
Bone: stiffness0.81.35.3-0.00.0-0.10.10.90.51.40.91.40.6-0.61.00.20.51.31.11.4-2.31.31.71.9
Tibialis anterior weight2.06.913.12.6-2.62.7-2.7-3.12.6-3.0-3.6-3.1-3.03.01.8-2.33.1-3.3-3.21.81.51.6-0.4-1.9
Time to tail flick, vehicle, before self-admin0.10.10.4-0.20.2-0.10.10.20.30.00.00.4-0.00.00.4-0.3-0.30.10.30.2-0.10.20.70.1
Time to tail flick, vehicle, after self-admin0.60.71.7-1.11.1-1.11.11.1-1.2-0.1-0.11.11.3-1.3-0.7-0.6-0.50.20.8-0.10.50.1-0.10.9
Time to tail flick, test, before self-admin0.40.42.30.4-0.40.4-0.4-0.60.4-0.1-0.3-0.7-0.70.70.10.40.5-0.9-1.50.10.4-0.8-0.3-1.2
Time to tail flick, test, after self-admin0.20.21.20.2-0.20.2-0.2-0.4-0.4-0.3-0.5-0.6-0.0-0.0-0.4-0.10.1-0.6-0.2-0.40.8-0.2-1.1-0.2
Delta time to tail flick, vehicle, before/after SA0.30.31.20.1-0.10.0-0.00.30.1-0.00.10.50.3-0.30.3-0.70.70.50.50.8-0.50.90.51.1
Delta time to tail flick, test, before/after SA0.50.52.8-0.10.1-0.10.1-0.4-0.6-1.0-1.1-0.70.0-0.0-0.7-0.7-0.1-1.0-0.4-0.71.70.1-1.4-0.2
Tibia length0.30.84.6-0.20.2-0.10.10.90.10.51.41.40.5-0.50.60.0-1.01.51.10.1-2.20.01.50.7
Ambulatory time before self-admin1.11.72.91.7-1.71.6-1.6-1.61.5-1.1-1.3-1.4-1.51.51.2-1.01.6-1.0-0.61.10.31.20.1-0.3
Ambulatory time after self-admin0.40.52.60.3-0.30.3-0.30.00.5-0.9-0.70.5-0.0-0.00.9-1.60.40.00.50.6-0.51.40.70.9
Bone: tissue strength0.40.40.8-0.50.5-0.60.60.8-0.60.60.80.80.7-0.7-0.40.7-0.90.70.7-0.7-0.5-0.6-0.10.2
Total heroin consumption0.70.82.21.0-1.01.0-1.0-0.81.5-0.8-0.4-0.5-1.31.31.3-0.71.0-0.5-1.00.9-0.40.30.7-0.8
Bone: trabecular number0.20.30.8-0.60.6-0.50.50.3-0.70.20.30.00.3-0.3-0.80.8-0.70.10.2-0.90.8-0.7-0.6-0.4
Bone: trabecular spacing0.71.05.40.5-0.50.5-0.50.30.81.00.70.80.2-0.31.4-0.40.10.90.51.2-2.31.01.91.3
Bone: trabecular thickness0.40.42.9-0.20.2-0.10.1-0.1-0.7-0.1-0.4-0.50.3-0.2-1.11.00.1-0.7-0.3-0.61.7-0.6-1.2-0.4
Bone: trabecular tissue density0.30.41.3-0.40.4-0.30.30.0-0.6-1.1-1.1-0.20.4-0.4-0.8-0.70.7-0.8-0.5-0.10.80.4-1.00.3
Water consumed over 24 hours0.10.10.70.1-0.10.2-0.20.20.1-0.1-0.60.40.3-0.40.5-0.8-0.0-0.7-0.50.30.20.20.40.3
Number of responses in last shaping day5.05.411.12.9-2.92.9-2.9-2.23.3-0.9-1.6-1.1-2.42.43.0-1.63.1-1.0-1.43.2-1.42.82.00.4