Hub : Genes

Izumo4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Izumo4 0.09 0.06 5.6e-05 0.04 0.03 0.04 0.03 1.4e-04 1.7e-03 1.6e-04 3.8e-04
2 Adipose gene expression Izumo4 0.3 0.14 0.0e+00 0.21 0.22 0.22 0.22 3.5e-23 9.9e-24 6.0e-24 5.3e-24
3 BLA intron excision ratio chr7_9658924_9659145 0.04 0.03 8.2e-03 0.02 0.03 0.01 0.02 1.8e-02 1.6e-02 5.5e-02 2.8e-02
4 OFC mRNA stability Izumo4 0.16 0.11 4.8e-04 0.13 0.14 0.13 0.14 4.5e-04 2.6e-04 4.6e-04 3.0e-04
5 pVTA gene expression Izumo4 0.18 0.1 5.0e-07 0.08 0.08 0.07 0.07 6.7e-07 6.2e-07 1.9e-06 1.9e-06
6 IC isoform ratio XM_017595154.3 0.11 0.08 2.4e-04 0.07 0.05 0.05 0.05 1.0e-03 4.1e-03 4.7e-03 3.4e-03
7 PL gene expression Izumo4 0.09 0.06 2.5e-04 0.03 0.04 0.03 0.04 7.7e-04 2.9e-05 1.4e-04 6.4e-05
8 PL isoform ratio XM_017595154.3 0.03 0.02 8.5e-05 0.03 0.02 0.01 0.02 1.5e-04 1.4e-03 1.4e-02 1.2e-03
9 NAcc isoform ratio XM_017595154.3 0.03 0.02 9.1e-04 0.01 0.01 0.01 0.01 6.4e-03 6.0e-03 1.9e-03 1.0e-02
10 Adipose intron excision ratio chr7_9658291_9658639 0.04 0.04 9.0e-03 0.02 0.01 0.02 0.01 4.5e-03 6.9e-03 6.2e-03 1.0e-02
11 BLA isoform ratio XM_017595154.3 0.09 0.09 1.4e-04 0.05 0.06 0.07 0.06 8.3e-04 5.2e-04 1.1e-04 6.1e-04
12 NAcc gene expression Izumo4 0.47 0.16 4.2e-10 0.05 0.07 0.06 0.07 1.1e-07 2.0e-11 8.6e-10 2.5e-10

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density1.01.84.80.9-0.7-0.1-0.1-1.70.7-1.80.71.9-2.20.6-2.1
Area under the delay curve1.01.52.7-1.41.4-1.6-1.61.01.70.91.41.10.31.20.4
BMI with tail4.917.225.7-4.95.1-4.9-4.93.94.63.74.72.91.14.23.0
BMI without tail1.05.48.5-2.92.8-2.6-2.62.62.22.42.40.91.22.31.9
Body weight0.73.04.5-2.02.1-2.1-2.11.61.91.52.11.20.41.81.2
Weight adjusted by age0.20.71.4-1.10.9-0.7-0.71.20.41.20.6-0.21.10.80.8
Bone surface2.24.411.21.9-1.80.70.6-3.00.3-3.10.32.2-3.20.2-3.3
Bone volume2.24.412.41.9-1.70.60.5-2.90.3-3.10.32.2-3.20.2-3.5
Breakpoint value in progressive ratio session1.83.27.81.8-1.92.12.2-1.1-2.1-0.9-2.2-1.80.1-2.8-0.4
Number of licking bursts0.20.71.9-0.80.5-0.2-0.21.2-0.21.2-0.2-1.11.40.11.2
Context. condit. distance diff. score0.30.40.5-0.70.7-0.7-0.70.60.60.60.70.30.50.60.4
Locomotion velocity, session 11.11.32.61.3-1.10.80.8-1.6-0.4-1.6-0.40.6-1.6-0.5-1.6
Locomotion distance, session 11.72.28.01.4-0.80.50.5-2.10.1-2.10.11.6-2.8-0.1-1.8
Locomotion velocity, session 24.55.410.12.9-2.52.32.2-3.2-1.5-3.1-1.70.3-2.6-1.7-2.4
Locomotion distance, session 23.24.69.42.6-2.01.71.7-3.0-1.0-3.0-1.11.0-3.1-1.2-2.5
Locomotion velocity, session 34.24.87.32.5-2.62.72.7-1.7-2.6-1.5-2.7-2.10.1-2.5-0.8
Locomotion distance, session 30.10.10.3-0.30.1-0.1-0.00.3-0.00.3-0.0-0.30.50.10.3
Stereotopy head waving bouts, day 34.25.08.83.0-2.52.62.5-2.4-2.2-2.2-2.5-1.0-1.2-2.4-1.4
Stereotopy head waving duration, day 34.75.89.63.1-2.72.82.8-2.4-2.5-2.2-2.9-1.4-0.8-2.8-1.3
Locomotion velocity, session 70.40.41.00.4-1.00.70.7-0.3-0.8-0.3-0.6-0.80.3-0.2-1.0
Locomotion distance, session 70.60.71.8-1.00.6-0.5-0.51.30.11.30.3-0.71.30.40.8
Stereotopy head waving bouts, day 70.50.61.50.6-0.30.0-0.0-1.10.4-1.10.11.1-1.20.2-1.0
Stereotopy head waving duration, day 71.01.22.81.3-1.00.70.6-1.7-0.2-1.7-0.40.8-1.5-0.3-1.5
Locomotion velocity, session 81.72.04.71.6-1.30.90.8-2.1-0.3-2.1-0.41.1-2.2-0.3-1.9
Locomotion distance, session 80.30.51.30.8-0.50.50.4-1.0-0.2-1.0-0.20.5-1.1-0.3-0.7
Degree of sensitization distance0.30.40.6-0.70.6-0.7-0.70.50.70.40.80.50.00.70.1
Degree of sensitization stereotypy1.11.32.6-0.91.0-1.3-1.30.21.60.01.41.6-0.61.5-0.3
Conditioned locomotion1.82.24.0-1.71.8-1.4-1.32.00.92.00.9-0.21.60.71.9
Cocaine response after cond. corrected4.36.510.4-3.12.9-2.7-2.73.22.13.12.10.42.42.12.4
Cocaine response after cond. not corrected4.86.911.2-3.33.0-2.8-2.73.32.23.32.20.32.52.12.6
Cocaine response before conditioning0.40.50.80.8-0.90.80.8-0.8-0.7-0.8-0.7-0.4-0.4-0.8-0.7
Saline control response0.20.30.7-0.60.7-0.4-0.40.80.20.80.2-0.20.6-0.30.8
Bone: connectivity density0.61.02.70.2-0.1-0.5-0.5-1.01.0-1.10.91.7-1.61.0-1.3
Bone: cortical apparent density0.50.81.3-1.01.0-1.1-1.10.61.10.51.10.9-0.00.90.3
Bone: cortical area0.40.71.8-0.20.1-0.7-0.7-0.41.0-0.61.01.3-0.81.0-1.2
Bone: cortical porosity0.40.51.20.7-0.60.40.4-0.9-0.2-1.0-0.20.4-1.0-0.0-1.1
Bone: cortical porosity0.70.82.20.7-0.50.20.1-1.20.2-1.30.31.1-1.50.2-1.4
Bone: cortical thickness0.71.12.4-0.70.9-1.2-1.30.21.50.01.51.5-0.61.2-0.4
Bone: cortical thickness0.40.51.8-0.50.10.00.10.9-0.40.9-0.4-1.01.4-0.20.7
Bone: cortical tissue density0.30.50.8-0.90.8-0.9-0.90.50.90.40.90.7-0.10.70.2
Condit. Reinf. active minus inactive responses3.03.45.12.2-2.22.32.3-1.6-2.1-1.5-2.2-1.4-0.2-2.1-0.8
Condit. Reinf. active-inactive response ratio1.41.52.71.1-1.31.51.5-0.4-1.6-0.3-1.6-1.60.8-1.50.1
Condit. Reinf. active responses3.34.37.32.7-2.42.32.3-2.5-1.9-2.3-2.0-0.5-1.4-2.0-1.6
Condit. Reinf. inactive responses1.62.14.71.6-1.31.11.1-2.1-0.6-2.1-0.50.8-2.2-0.6-1.7
Incentive salience index mean2.02.64.22.1-1.91.81.8-2.0-1.4-1.9-1.5-0.3-1.2-1.5-1.3
Condit. Reinf. lever presses1.11.75.91.1-0.70.30.3-1.80.3-1.90.31.6-2.40.1-1.7
Condit. Reinf. active minus inactive responses1.42.14.21.2-1.41.71.7-0.3-1.9-0.1-1.9-2.11.0-1.8-0.0
Condit. Reinf. active-inactive response ratio0.40.71.7-0.30.30.20.21.0-0.61.1-0.6-1.31.3-0.41.2
Condit. Reinf. active responses1.62.33.61.5-1.81.81.8-0.8-1.9-0.7-1.9-1.70.6-1.9-0.8
Condit. Reinf. inactive responses0.81.32.31.2-1.51.21.2-0.9-1.2-0.9-1.2-0.80.2-1.4-1.1
Condit. Reinf. lever presses1.21.83.61.1-1.41.61.6-0.4-1.8-0.3-1.8-1.90.8-1.7-0.1
Condit. Reinf. lever reinforcers received1.21.73.21.1-1.41.51.5-0.3-1.7-0.2-1.7-1.81.0-1.7-0.3
Conditioned reinforcement - actives0.31.03.20.4-0.91.11.20.2-1.50.2-1.1-1.81.1-0.40.1
Conditioned reinforcement - inactives0.10.30.7-0.60.4-0.2-0.20.70.00.70.1-0.40.80.40.6
Conditioned locomotion4.77.111.22.9-3.33.33.3-2.2-3.1-2.1-3.0-2.2-0.4-2.7-2.0
Patch foraging indifference point 0 sec0.10.20.4-0.30.3-0.5-0.5-0.00.5-0.10.60.6-0.40.6-0.3
Patch foraging indifference point AUC0.30.81.51.0-1.01.11.1-0.4-1.2-0.4-1.1-1.10.1-1.0-0.3
Delay disc. indifference point, 0s delay5.25.911.8-1.92.3-2.8-2.80.43.30.13.23.4-1.83.1-0.5
Delay disc. indifference point, 16s delay0.10.10.3-0.20.3-0.4-0.40.10.50.10.40.40.10.10.1
Delay disc. indifference point, 2s delay4.04.58.0-2.22.3-2.7-2.71.12.80.92.62.4-0.62.40.2
Delay disc. indifference point, 24s delay0.40.60.9-0.90.7-0.8-0.81.00.70.90.70.20.60.80.4
Delay disc. indifference point, 4s delay0.80.92.0-0.80.8-1.2-1.20.31.40.21.01.3-0.21.1-0.2
Delay disc. indifference point, 8s delay0.71.21.9-1.31.2-1.3-1.31.41.11.30.90.31.00.90.7
Indifference point function ln k0.10.30.6-0.80.4-0.5-0.50.60.40.50.40.00.70.60.2
Indifference point function log k0.10.30.6-0.80.4-0.5-0.50.60.40.50.40.00.70.60.2
Patch foraging total patch changes 0 sec0.00.10.3-0.20.3-0.4-0.40.00.5-0.10.50.5-0.30.5-0.2
Patch foraging total patch changes 12 sec0.40.61.1-0.91.0-0.7-0.71.10.51.00.5-0.10.50.60.9
Patch foraging total patch changes 18 sec0.41.01.51.2-1.11.11.1-0.9-1.1-0.9-1.1-0.7-0.5-1.1-0.6
Patch foraging total patch changes 24 sec0.00.10.50.5-0.30.30.3-0.4-0.3-0.4-0.3-0.0-0.5-0.7-0.2
Patch foraging total patch changes 6 sec0.20.40.80.9-0.70.60.6-0.8-0.5-0.8-0.40.0-0.7-0.4-0.7
Patch foraging time to switch 0 sec0.52.06.3-0.41.1-1.2-1.3-0.71.7-0.81.72.5-2.11.3-0.5
Patch foraging water rate 0 sec0.41.55.5-1.00.2-0.1-0.11.7-0.51.7-0.4-1.82.40.41.2
Patch foraging water rate 12 sec0.72.96.2-2.11.6-1.4-1.32.50.82.50.8-0.82.31.02.0
Patch foraging water rate 18 sec1.63.611.9-1.40.7-0.00.12.5-0.92.6-0.9-2.73.4-0.62.4
Patch foraging water rate 24 sec2.73.810.5-2.11.4-0.9-0.82.90.03.00.1-1.93.20.62.6
Patch foraging water rate 6 sec1.11.65.2-0.4-0.10.40.51.4-1.11.5-1.1-2.22.3-0.81.2
Seeking ratio, delayed vs. immediate footshock2.94.26.42.4-2.52.32.3-2.0-2.1-1.9-2.1-1.2-0.8-2.5-1.6
Distance traveled before self-admin0.10.20.6-0.30.0-0.3-0.3-0.10.6-0.20.60.7-0.50.4-0.8
Distance traveled after self-admin0.00.10.30.1-0.30.20.2-0.2-0.1-0.20.00.1-0.2-0.3-0.6
Extensor digitorum longus weight3.614.321.1-4.64.5-4.4-4.34.13.93.93.91.82.23.53.0
Bone: elastic displacement0.10.20.30.5-0.50.50.5-0.4-0.4-0.4-0.4-0.2-0.1-0.3-0.4
Bone: elastic work0.20.30.6-0.40.3-0.6-0.60.10.70.00.70.7-0.00.7-0.5
Bone: endosteal estimation0.10.30.7-0.40.3-0.6-0.60.00.7-0.00.70.7-0.20.8-0.2
Bone: endosteal perimeter0.30.71.61.0-1.20.80.8-1.1-0.5-1.2-0.60.0-0.6-0.2-1.3
Epididymis fat weight0.20.92.7-0.60.6-0.2-0.21.2-0.11.3-0.4-1.11.5-0.31.6
Delta time in closed arm before/after self-admin2.82.66.2-1.81.4-0.9-0.82.40.22.50.3-1.32.50.32.2
Delta time in open arm before/after self-admin0.30.40.9-0.60.7-0.8-0.80.40.90.40.70.70.00.60.3
Diff in mean of infusions in LGA sessions0.91.53.91.5-1.21.41.4-1.1-1.2-1.0-1.5-0.9-0.3-2.0-0.3
Delay discount exponential model param1.01.32.21.3-1.21.51.5-1.0-1.5-0.9-1.2-0.9-0.5-1.1-0.4
Extinction: sum of active levers before priming0.50.82.20.6-0.71.01.00.0-1.20.1-1.0-1.30.5-1.50.2
Active lever presses in extinction session 62.02.03.21.6-1.81.71.7-1.4-1.5-1.4-1.3-0.7-0.7-1.4-1.5
Bone: final force0.91.42.9-0.80.7-1.4-1.40.11.6-0.11.61.7-0.61.5-0.9
Bone: final moment0.71.22.5-0.70.6-1.2-1.30.11.5-0.11.51.6-0.61.4-0.8
Food consumed during 24 hour testing period0.30.61.1-1.00.8-0.9-0.90.90.80.80.80.30.60.70.4
Glucose2.03.14.6-2.12.0-2.1-2.11.82.01.62.01.00.72.00.9
Heart weight0.61.02.90.3-0.40.80.80.6-1.10.7-1.2-1.71.6-1.10.9
Delay discount hyperbolic model param1.72.23.91.7-1.61.91.9-1.1-2.0-1.0-1.7-1.4-0.3-1.5-0.3
Intermittent access intake day 1-15 change0.84.48.42.0-2.32.62.6-0.9-2.9-0.7-2.6-2.70.8-2.3-0.5
Intermittent access intake escalation0.73.97.41.9-2.22.42.5-0.8-2.7-0.7-2.5-2.50.8-2.2-0.4
Intermittent access intake escalation 22.13.56.51.9-2.12.32.3-0.9-2.5-0.8-2.3-2.30.6-2.2-0.5
Intermitt. access day 1 inactive lever presses0.10.93.1-0.5-0.10.20.31.3-0.71.2-0.6-1.51.8-0.20.7
Intermitt. access day 15 inactive lever presses0.10.30.50.7-0.60.70.7-0.6-0.6-0.5-0.7-0.3-0.2-0.4-0.4
Intermitt. access escalation Index0.30.92.3-0.40.5-0.8-0.9-0.41.1-0.51.31.5-1.11.3-0.7
Intermittent access day 1 total infusions0.10.31.1-0.3-0.20.30.30.6-0.40.6-0.5-1.01.10.00.4
Intermittent access day 15 total infusions0.92.34.31.3-1.81.91.9-0.6-2.0-0.5-1.9-2.10.8-1.4-0.5
Intermittent access terminal intake (last 3 days)0.91.52.81.0-1.51.51.6-0.5-1.6-0.4-1.5-1.70.6-1.0-0.6
Intermittent access total infusions0.60.71.80.5-1.01.01.1-0.1-1.1-0.1-1.0-1.30.7-0.4-0.3
Intermittent access day 1 locomotion0.71.33.60.5-0.91.21.30.2-1.50.3-1.5-1.91.3-1.30.6
Intermittent access day 15 total locomotion0.93.46.21.8-2.02.32.4-0.7-2.5-0.6-2.3-2.30.8-2.0-0.2
Intermittent access total locomotion1.51.83.41.1-1.51.71.7-0.4-1.8-0.3-1.6-1.90.8-1.5-0.2
Intermittent access standard deviation1.05.38.62.5-2.92.92.9-1.7-2.8-1.6-2.7-2.10.1-2.1-1.6
Left kidney weight0.10.62.1-0.80.5-0.2-0.21.2-0.21.2-0.1-1.01.4-0.01.0
Right kidney weight0.21.64.50.6-0.91.21.30.3-1.60.4-1.6-2.11.6-1.40.4
Cocaine induced anxiety0.82.34.31.9-1.61.41.3-2.1-1.0-2.0-0.90.3-1.8-1.3-1.7
Post-drug Anxiety2.02.34.61.9-1.51.31.2-2.1-0.7-2.1-0.90.6-1.9-1.6-1.5
Baseline Anxiety0.00.10.30.1-0.30.20.20.0-0.10.0-0.3-0.40.3-0.6-0.1
Tail length1.79.114.73.1-3.63.73.7-2.0-3.8-1.9-3.7-3.20.3-3.1-1.6
Length with tail1.35.79.02.6-2.82.92.9-1.7-3.0-1.5-2.9-2.50.1-2.6-1.1
Length without tail0.00.00.1-0.20.1-0.1-0.10.20.10.20.1-0.10.20.10.1
Times rat made contact with spout0.40.51.2-0.80.7-0.5-0.51.10.21.10.2-0.31.10.20.9
Lifetime Intake0.30.41.20.2-0.70.70.70.1-0.80.1-0.8-1.10.7-0.2-0.1
Liver weight, left0.71.31.9-1.31.4-1.3-1.31.11.31.11.20.60.51.01.0
Liver weight, right0.61.12.0-1.41.0-1.1-1.11.40.91.31.00.11.11.10.8
Locomotor activity3.45.48.32.9-2.82.42.4-2.7-2.0-2.6-1.9-0.6-1.8-2.2-2.7
Locomotor testing distance1.53.65.52.4-2.31.91.9-2.2-1.6-2.2-1.5-0.4-1.5-2.0-2.2
Locomotor testing rearing0.10.20.7-0.1-0.10.10.20.5-0.30.5-0.4-0.70.8-0.60.3
Locomotion in novel chamber0.71.02.21.0-1.01.21.2-0.4-1.3-0.3-1.1-1.10.1-1.5-0.3
Locomotion in novel chamber post-restriction0.41.33.21.0-1.31.31.3-0.5-1.4-0.5-1.5-1.40.5-1.8-0.4
Fecal boli incidents, locomotor time 10.51.42.7-1.01.7-1.4-1.41.21.31.11.61.00.20.61.0
Change in fecal boli incidents, locomotor task0.50.52.60.3-1.00.50.5-0.8-0.4-0.9-0.2-0.3-0.40.6-1.6
Time >=10cm from walls, locomotor time 10.70.82.1-0.00.1-0.5-0.5-0.50.6-0.71.21.3-1.31.2-1.5
Bouts of movement, locomotor time 10.20.20.50.2-0.50.60.6-0.1-0.7-0.1-0.5-0.70.4-0.0-0.1
Total resting periods, locomotor time 10.20.30.50.4-0.70.70.7-0.3-0.7-0.3-0.5-0.60.2-0.2-0.3
Rest time, locomotor task time 10.20.30.50.6-0.60.60.6-0.7-0.4-0.7-0.2-0.1-0.5-0.1-0.6
Distance moved, locomotor task time 10.30.92.3-0.30.3-0.8-0.8-0.41.0-0.61.11.5-1.21.5-1.2
Vertical activity count, locomotor time 10.00.30.8-0.80.4-0.5-0.50.80.30.70.3-0.30.90.70.0
Time >=10cm from walls, locomotor time 20.41.22.0-1.41.2-1.2-1.21.40.91.31.20.30.81.00.4
Bouts of movement, locomotor time 20.30.81.91.1-0.80.70.7-1.4-0.3-1.3-0.50.5-1.3-0.1-1.0
Total resting periods, locomotor time 20.20.92.01.1-0.80.70.6-1.4-0.3-1.4-0.50.7-1.4-0.1-1.1
Rest time, locomotor task time 20.50.81.41.2-1.00.90.9-1.2-0.7-1.2-0.70.0-0.9-0.6-1.0
Distance moved, locomotor task time 20.50.71.0-1.01.0-0.9-0.91.00.71.00.70.30.50.90.8
Vertical activity count, locomotor time 20.51.12.4-1.21.1-0.9-0.91.50.51.50.6-0.41.30.71.2
Light reinforcement 11.98.712.93.6-3.43.43.4-3.1-3.1-2.9-3.0-1.5-1.7-3.3-1.9
Light reinforcement 21.02.33.51.9-1.71.81.8-1.7-1.5-1.6-1.5-0.6-1.0-1.6-1.1
Bone: marrow area0.10.30.7-0.40.3-0.6-0.60.00.7-0.00.70.7-0.20.8-0.2
Bone: maximum diameter1.02.03.61.7-1.81.41.3-1.8-1.0-1.9-1.00.0-1.2-0.9-1.9
Bone: maximum force0.71.42.7-1.10.9-1.5-1.50.51.60.31.61.5-0.21.6-0.5
Bone: maximum moment0.61.22.3-1.00.8-1.4-1.40.41.50.21.51.4-0.21.5-0.5
Mean time between licks in bursts0.74.46.72.3-2.42.62.6-1.5-2.6-1.3-2.6-2.0-0.0-2.4-0.7
Mean num. licks in bursts0.00.10.40.10.0-0.2-0.2-0.30.3-0.30.30.6-0.30.0-0.3
Cd content in liver0.20.20.40.6-0.50.50.5-0.6-0.4-0.5-0.4-0.1-0.4-0.6-0.4
Co content in liver1.11.32.31.2-1.21.41.4-0.6-1.5-0.5-1.5-1.30.3-1.5-0.2
Cu content in liver0.70.82.10.9-0.90.60.5-1.3-0.2-1.3-0.20.6-1.3-0.0-1.4
Fe content in liver0.10.10.30.2-0.20.40.40.1-0.50.1-0.5-0.60.3-0.30.3
K content in liver0.50.51.50.7-0.50.20.2-1.00.1-1.00.10.8-1.2-0.1-1.1
Mg content in liver0.40.40.70.8-0.80.60.6-0.8-0.5-0.8-0.50.1-0.7-0.5-0.7
Mn content in liver2.83.16.52.0-2.01.41.4-2.5-0.8-2.5-0.80.6-2.1-0.4-2.6
Na content in liver0.80.92.8-0.20.5-0.8-0.9-0.41.2-0.51.21.7-1.41.0-0.7
Rb content in liver0.70.82.20.7-0.60.20.2-1.30.2-1.30.21.0-1.50.0-1.3
Se content in liver0.10.10.30.4-0.40.50.5-0.3-0.5-0.2-0.5-0.4-0.0-0.3-0.1
Sr content in liver0.10.10.3-0.30.3-0.1-0.10.5-0.00.5-0.0-0.30.6-0.10.5
Zn content in liver2.93.38.01.2-1.42.02.00.1-2.40.3-2.4-2.81.6-2.30.8
Bone: minimum diameter0.10.20.90.2-0.4-0.1-0.1-0.50.3-0.60.30.6-0.50.3-0.9
Time in familiar zone, hab. session 11.31.52.81.2-1.21.41.4-0.4-1.5-0.3-1.7-1.60.7-1.60.1
Time in novel zone, hab. session 10.91.02.4-0.80.5-0.9-1.0-0.21.2-0.31.31.5-0.91.6-0.9
Total zone transitions, hab. session 11.72.45.11.8-1.51.21.2-2.2-0.7-2.2-0.90.8-2.3-0.8-1.8
Total locomotion distance, hab. session 12.73.88.22.2-1.81.41.3-2.9-0.7-2.9-0.91.1-2.8-0.7-2.6
Locomotion velocity, hab. session 12.84.08.12.4-1.91.71.6-2.8-1.0-2.8-1.20.8-2.7-1.3-2.3
Time in familiar zone, hab. session 24.04.57.82.0-2.22.52.6-0.8-2.8-0.6-2.8-2.81.0-2.70.0
Time in novel zone, hab. session 23.03.35.9-1.71.7-2.2-2.20.62.40.42.42.4-0.82.4-0.3
Total zone transitions, hab. session 21.82.39.90.8-0.1-0.2-0.2-1.90.9-1.90.82.5-3.10.6-1.5
Total locomotion distance, hab. session 22.02.66.02.0-1.41.31.3-2.3-0.7-2.2-1.00.8-2.4-1.2-1.5
Locomotion velocity, hab. session 22.53.38.82.2-1.41.31.3-2.7-0.6-2.6-0.91.2-3.0-1.1-1.8
Novel to familiar place preference ratio2.63.46.8-1.61.5-2.0-2.10.32.40.02.52.6-1.32.6-0.7
Novelty place preference1.72.24.6-1.21.1-1.5-1.60.01.9-0.22.02.1-1.32.1-0.8
Time in novel zone, NPP test1.92.44.8-1.41.2-1.7-1.70.22.00.02.12.1-1.12.2-0.6
Total zone transitions, NPP test0.81.25.70.9-0.10.10.1-1.50.4-1.40.21.6-2.4-0.2-0.8
Total locomotion distance, NPP test0.81.24.90.9-0.20.10.0-1.50.5-1.50.21.6-2.2-0.1-1.1
Locomotion velocity, NPP test0.91.35.11.2-0.50.40.3-1.70.2-1.7-0.11.4-2.3-0.4-1.2
Intraocular pressure0.91.44.0-0.80.7-0.2-0.11.6-0.41.7-0.3-1.42.0-0.71.9
Delta distance traveled before/after self-admin0.30.31.00.5-0.40.60.6-0.2-0.9-0.1-0.7-0.70.2-1.00.2
Delta ambulatory time before/after self-admin0.20.30.70.6-0.50.60.6-0.5-0.8-0.4-0.6-0.4-0.1-0.7-0.0
Parametrial fat weight0.10.10.50.2-0.20.10.0-0.50.1-0.50.20.4-0.70.2-0.6
Pavlov. Cond. lever latency0.81.03.2-0.90.5-0.2-0.11.3-0.31.4-0.1-1.31.8-0.01.3
Pavlov. Cond. magazine entry latency2.22.84.22.0-1.92.02.0-1.4-2.0-1.3-2.0-1.3-0.4-2.0-0.6
Pavlov. Cond. change in total contacts0.10.10.20.3-0.20.20.2-0.3-0.2-0.3-0.20.1-0.4-0.2-0.2
Pavlov. Cond. index score0.60.71.41.1-0.90.80.8-1.2-0.5-1.1-0.70.2-1.0-0.7-0.8
Pavlov. Cond. latency score0.81.02.21.3-1.00.80.7-1.5-0.4-1.4-0.60.5-1.5-0.6-1.1
Pavlov. Cond. lever contacts0.60.72.60.7-0.40.10.1-1.20.3-1.20.11.2-1.60.1-1.1
Pavlov. Cond. magazine entry number0.50.71.2-1.00.9-1.0-1.00.71.00.61.10.70.21.10.0
Pavlov. Cond. intertrial magazine entries0.40.41.30.0-0.00.30.30.6-0.60.7-0.6-1.11.1-0.60.9
Pavlov. Cond. lever-magazine prob. diff.0.60.81.31.2-1.00.90.9-1.2-0.6-1.1-0.80.0-0.9-0.8-0.8
Pavlov. Cond. response bias0.60.71.21.1-0.91.01.0-0.8-1.0-0.7-1.1-0.6-0.3-1.1-0.2
Pavlov. Cond. lever latency0.50.81.3-0.71.1-1.0-1.00.41.10.51.01.1-0.40.80.8
Pavlov. Cond. magazine entry latency0.30.40.90.5-0.90.70.7-0.4-0.7-0.4-0.6-0.80.2-0.1-0.6
Pavlov. Cond. change in total contacts0.30.61.40.6-0.90.90.9-0.2-1.0-0.1-1.0-1.20.6-0.8-0.4
Pavlov. Cond. index score0.40.61.40.6-1.00.90.9-0.3-1.0-0.3-0.9-1.20.5-0.5-0.6
Pavlov. Cond. latency score0.40.71.30.7-1.20.90.9-0.5-1.0-0.5-0.9-1.00.2-0.4-0.9
Pavlov. Cond. lever contacts0.40.61.70.4-0.90.80.8-0.1-1.0-0.1-0.9-1.30.7-0.7-0.4
Pavlov. Cond. magazine entry number0.50.61.5-0.71.2-0.9-0.90.60.90.60.91.0-0.10.20.9
Pavlov. Cond. intertrial magazine entries0.20.51.0-0.80.9-0.7-0.71.00.51.00.50.00.9-0.20.9
Pavlov. Cond. lever-magazine prob. diff.0.40.71.30.7-1.20.91.0-0.5-1.0-0.5-0.9-1.10.2-0.5-0.8
Pavlov. Cond. response bias1.11.53.40.9-1.41.41.4-0.4-1.6-0.3-1.5-1.80.8-1.3-0.5
Time in closed arm before self-admin0.40.72.30.00.4-0.6-0.6-0.60.9-0.70.91.5-1.30.4-0.6
Time in closed arm after self-admin0.30.31.30.00.00.30.30.3-0.50.4-0.5-0.80.7-1.20.7
Time in open arm before self-admin0.20.20.60.3-0.60.50.5-0.3-0.6-0.4-0.2-0.4-0.20.3-0.7
Time in open arm after self-admin0.80.82.5-1.00.9-1.0-1.00.71.00.71.00.70.21.60.3
Bone: periosteal estimation0.30.61.7-0.0-0.0-0.6-0.6-0.60.9-0.70.91.3-0.90.9-1.1
Bone: periosteal perimeter0.40.72.60.9-1.00.40.4-1.2-0.1-1.2-0.10.5-0.90.1-1.6
Bone: post-yield work0.40.71.1-1.00.9-1.0-1.00.91.00.80.90.50.50.90.5
Progressive ratio test 1 active lever presses0.30.62.3-0.50.10.10.10.9-0.41.0-0.4-1.11.50.10.9
Progressive ratio test 1 breakpoint0.30.62.3-0.60.20.00.11.0-0.31.0-0.4-1.11.50.20.9
Progressive ratio test 1 inactive lever presses0.10.30.70.1-0.30.50.50.2-0.60.3-0.5-0.80.8-0.50.4
Progressive ratio test 2 active lever presses0.50.82.9-0.5-0.20.40.41.0-0.71.0-0.5-1.51.70.30.6
Progressive ratio test 2 breakpoint0.60.82.9-0.4-0.30.40.51.0-0.81.0-0.6-1.51.70.20.6
Progressive ratio test 2 inactive lever presses0.00.10.20.1-0.40.40.40.0-0.4-0.0-0.2-0.40.20.2-0.3
Incentive Sensitization - Responses0.20.72.0-0.80.4-0.2-0.11.3-0.21.20.1-1.01.40.70.8
Incentive Sensitization - Breakpoint0.20.51.6-0.60.2-0.00.01.1-0.31.00.0-1.01.30.50.7
Sum of active levers in priming session hrs 5-60.00.00.4-0.00.1-0.1-0.10.10.00.10.20.1-0.0-0.6-0.1
Progressive ratio0.20.62.1-0.61.1-0.6-0.60.90.51.00.40.20.40.41.4
Food seeking constrained by brief footshock0.20.30.60.7-0.20.50.5-0.6-0.3-0.5-0.40.1-0.7-0.80.2
Seeking ratio, punishment vs. effort0.30.61.10.9-0.80.70.7-1.0-0.4-1.0-0.50.0-0.8-1.0-0.8
Retroperitoneal fat weight0.52.34.4-1.82.0-1.5-1.41.91.22.01.0-0.01.30.82.1
Reaction time number correct0.51.94.5-1.71.3-1.0-0.92.00.42.00.4-0.82.10.71.8
Reaction time mean minus median0.10.51.20.6-1.10.80.9-0.3-0.9-0.2-0.9-1.00.5-0.4-0.5
Reaction time mean minus median AUC0.10.41.60.3-0.70.0-0.0-0.70.3-0.80.30.6-0.80.8-1.3
Reaction time num false alarms0.50.82.7-1.00.5-0.5-0.51.30.21.20.2-0.81.60.80.6
Reaction time num false alarms AUC0.41.03.3-1.10.7-0.6-0.51.50.21.40.2-0.91.80.80.9
Reaction time trials correct on left0.51.94.5-1.71.3-1.0-0.92.00.42.00.4-0.82.10.71.8
Reaction time trials on left0.51.84.1-1.61.3-1.0-0.91.90.51.90.4-0.72.00.71.7
Reaction time mean0.10.20.70.1-0.4-0.1-0.1-0.40.3-0.50.30.4-0.50.8-0.8
Reaction time mean AUC0.10.20.70.0-0.3-0.2-0.2-0.40.3-0.50.40.5-0.50.8-0.9
Median of all reaction times0.30.41.2-0.20.1-0.5-0.6-0.30.7-0.40.80.9-0.71.1-0.7
Reaction time omissions0.30.51.10.8-0.70.50.5-1.0-0.2-1.0-0.10.4-1.1-0.4-1.0
Reaction time false alarm rate0.00.10.3-0.30.1-0.2-0.20.30.20.20.2-0.10.40.5-0.2
Reaction time premature initiation rate0.60.92.00.7-0.91.11.1-0.2-1.3-0.1-1.3-1.40.6-1.00.2
Reaction time premature initiations0.41.23.8-0.1-0.30.70.80.8-1.20.9-1.2-2.01.8-0.81.1
Std. dev. reaction times0.10.20.60.4-0.80.40.4-0.3-0.4-0.4-0.3-0.30.10.1-0.7
Reaction time trials completed0.51.84.1-1.61.3-1.0-0.91.90.51.90.4-0.72.00.71.7
Reaction time trials AUC0.62.25.2-1.71.3-1.0-0.92.10.42.10.4-0.92.30.71.9
Run reversals in cocaine runway, females0.60.71.30.9-1.00.80.8-1.1-0.5-1.1-0.60.1-0.6-0.5-1.0
Run reversals in cocaine runway, males1.61.73.71.7-1.41.41.4-1.5-1.1-1.4-1.3-0.4-0.7-1.9-0.9
Latency to leave start box in cocaine runway1.11.44.11.3-1.40.90.9-1.6-0.4-1.6-0.30.5-1.4-0.5-2.0
Latency to leave start box in cocaine runway, F1.31.65.70.8-0.80.20.1-1.50.5-1.70.61.5-2.00.3-2.4
Latency to leave start box in cocaine runway, M1.31.22.31.0-1.21.31.4-0.4-1.5-0.3-1.4-1.40.5-1.40.0
Std. dev. time between licks in bursts0.51.02.11.1-1.41.01.0-1.2-0.8-1.2-0.8-0.4-0.5-0.2-1.4
Total sessions with >9 infusions0.20.31.0-0.2-0.40.40.50.4-0.60.4-0.5-1.00.9-0.2-0.0
Short access day 1 total inactive lever presses0.10.20.50.4-0.30.60.6-0.1-0.7-0.0-0.6-0.50.4-0.30.1
Short access day 10 total inactive lever presses0.00.20.6-0.40.3-0.0-0.00.8-0.20.8-0.2-0.70.7-0.10.4
Short access day 1 total infusions0.10.20.40.3-0.50.60.6-0.2-0.6-0.2-0.5-0.50.2-0.4-0.1
Short access day 10 total infusions0.20.31.3-0.40.00.10.20.7-0.20.7-0.4-0.81.10.10.6
Short access total infusions0.20.20.80.0-0.40.50.60.2-0.60.2-0.6-0.90.6-0.1-0.0
Short access day 1 locomotion0.61.11.90.8-1.31.31.3-0.5-1.4-0.5-1.1-1.30.5-1.2-0.5
Short access day 10 total locomotion1.25.09.91.8-2.32.72.8-0.5-3.0-0.4-2.9-3.11.4-2.5-0.2
Short access total locomotion1.21.83.31.0-1.51.61.7-0.4-1.8-0.3-1.6-1.80.8-1.6-0.5
One hour access (0.3 mA shock)0.10.20.5-0.50.1-0.1-0.10.50.10.50.0-0.20.70.70.2
Compulsive drug intake0.81.23.6-0.40.5-0.9-1.0-0.51.4-0.61.41.9-1.51.0-1.0
One hour access (shock baseline)0.20.72.2-0.0-0.40.60.60.5-0.90.6-1.0-1.41.5-0.20.7
Social response proportion0.81.02.01.4-0.91.11.0-1.3-0.8-1.3-0.90.0-1.1-0.8-0.7
Social responses5.87.611.33.4-3.33.23.2-2.8-2.9-2.7-2.9-1.6-1.2-2.7-2.3
Social time0.30.41.0-0.61.0-0.7-0.80.50.70.50.70.7-0.30.10.7
Soleus weight6.118.027.2-4.94.9-5.2-5.23.75.03.45.03.31.04.52.2
Bone: stiffness1.62.95.2-1.81.6-2.1-2.10.92.30.72.21.9-0.22.30.1
Tibialis anterior weight0.82.64.0-1.91.7-2.0-2.01.52.01.41.91.20.51.60.7
Time to tail flick, vehicle, before self-admin0.20.31.10.5-0.40.30.3-0.6-0.1-0.6-0.20.2-0.5-1.1-0.6
Time to tail flick, vehicle, after self-admin0.51.02.7-0.10.20.40.40.9-0.61.1-0.9-1.51.7-0.81.6
Time to tail flick, test, before self-admin0.50.61.20.9-0.70.60.6-1.1-0.5-1.1-0.40.3-0.9-0.4-1.0
Time to tail flick, test, after self-admin0.10.10.40.3-0.20.30.3-0.2-0.2-0.2-0.3-0.2-0.0-0.60.1
Delta time to tail flick, vehicle, before/after SA1.31.43.7-1.11.1-0.6-0.51.60.31.70.0-0.81.80.51.9
Delta time to tail flick, test, before/after SA0.50.61.8-0.50.4-0.1-0.11.0-0.21.1-0.3-0.91.3-0.31.3
Tibia length0.61.62.91.4-1.41.61.6-0.8-1.6-0.7-1.7-1.30.1-1.3-0.5
Ambulatory time before self-admin0.10.20.5-0.30.0-0.3-0.3-0.00.6-0.10.60.6-0.40.4-0.7
Ambulatory time after self-admin0.00.10.40.1-0.30.10.1-0.2-0.0-0.30.20.3-0.4-0.2-0.6
Bone: tissue strength1.21.22.2-1.01.2-1.4-1.40.61.50.51.51.3-0.41.30.2
Total heroin consumption1.41.62.91.5-1.51.41.4-1.3-1.2-1.2-1.3-0.7-0.7-1.7-1.0
Bone: trabecular number0.71.32.81.3-1.30.90.8-1.7-0.4-1.7-0.50.5-1.4-0.4-1.7
Bone: trabecular spacing1.82.66.2-1.71.5-0.8-0.82.40.12.40.2-1.42.50.12.4
Bone: trabecular thickness2.73.810.61.4-1.20.10.1-2.50.7-2.70.82.4-3.20.8-3.2
Bone: trabecular tissue density0.91.63.1-1.41.8-1.4-1.41.31.31.31.30.70.50.91.3
Water consumed over 24 hours0.30.61.4-0.70.6-0.9-0.90.11.10.01.11.2-0.40.7-0.4
Number of responses in last shaping day0.91.22.50.7-1.11.31.3-0.1-1.4-0.1-1.4-1.61.0-1.2-0.2