Hub : Genes

Izumo4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Izumo4 0.06 0.05 5.4e-04 0.03 0.03 0.03 0.03 7.0e-04 1.8e-03 4.6e-04 1.4e-03
2 PL gene expression Izumo4 0.1 0.06 1.0e-06 0.06 0.06 0.05 0.05 9.1e-07 8.7e-07 2.5e-06 2.7e-06
3 Adipose gene expression Izumo4 0.34 0.15 0.0e+00 0.22 0.22 0.22 0.22 9.0e-24 7.3e-24 7.5e-24 6.0e-24
4 BLA mRNA stability Izumo4 0.05 0.04 5.4e-03 0.05 0.03 0.01 0.03 1.4e-03 9.6e-03 8.0e-02 9.9e-03
5 BLA gene expression Izumo4 0.14 0.14 9.8e-04 0.04 0.02 0.04 0.04 5.5e-03 2.7e-02 3.7e-03 3.2e-03
6 OFC mRNA stability Izumo4 0.11 0.09 5.4e-03 0.08 0.08 0.06 0.07 6.3e-03 5.2e-03 1.8e-02 8.3e-03
7 pVTA gene expression Izumo4 0.26 0.14 1.3e-04 0.06 0.08 0.07 0.08 1.8e-03 1.8e-04 8.1e-04 2.1e-04
8 NAcc isoform ratio XM_017595154.2 0.02 0.01 5.5e-03 0.01 0.01 0 0.01 1.4e-02 2.9e-02 1.3e-01 2.3e-02
9 PL isoform ratio XM_017595154.2 0.03 0.02 2.3e-04 0.04 0.03 0.02 0.03 5.4e-05 1.7e-04 4.0e-03 2.3e-04
10 BLA intron excision ratio chr7_9008225_9008446 0.04 0.03 7.2e-03 0.02 0.01 0.01 0.01 4.0e-02 7.4e-02 9.0e-02 1.2e-01
11 BLA isoform ratio XM_017595154.2 0.07 0.06 6.1e-04 0.04 0.04 0.05 0.04 3.2e-03 2.1e-03 1.8e-03 4.0e-03
12 Liver gene expression Izumo4 0.06 0.05 9.6e-03 0 0.01 0.02 0.01 8.5e-02 9.5e-03 6.4e-03 1.9e-02
13 NAcc gene expression Izumo4 0.39 0.17 5.0e-08 0.06 0.07 0.07 0.07 8.7e-08 1.1e-08 2.0e-08 1.1e-08
14 Adipose intron excision ratio chr7_9007592_9007940 0.04 0.03 9.5e-03 0.01 0.02 0.02 0.01 3.5e-02 5.7e-03 6.5e-03 8.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density1.21.95.11.0-1.5-1.0-1.1-1.10.0-2.00.70.70.60.72.3-2.22.3
Area under the delay curve1.71.83.8-1.51.21.21.31.2-1.60.81.61.71.52.0-0.40.31.1
BMI with tail5.618.223.7-4.94.34.84.94.8-4.83.64.54.54.64.3-3.33.22.0
BMI without tail2.85.88.5-2.92.92.72.72.7-2.42.81.91.92.12.1-2.52.4-0.1
Body weight1.04.25.5-2.32.22.32.32.3-2.31.82.12.22.32.1-1.51.50.9
Weight adjusted by age0.81.02.3-1.01.41.10.90.9-0.71.50.30.30.50.3-1.31.3-0.9
Bone surface2.84.913.11.9-2.6-2.1-2.1-2.10.6-3.30.40.30.20.53.6-3.42.9
Bone volume2.94.913.11.9-2.5-2.1-2.1-2.10.6-3.20.40.30.30.53.6-3.52.8
Breakpoint value in progressive ratio session3.74.06.51.9-1.6-2.1-2.1-2.12.5-1.0-2.6-2.5-2.5-2.30.7-0.4-2.1
Number of licking bursts0.50.61.7-0.80.90.60.60.6-0.21.2-0.1-0.2-0.2-0.1-1.21.3-1.1
Context. condit. distance diff. score0.30.30.5-0.70.70.60.60.6-0.60.70.60.60.60.6-0.50.50.1
Locomotion velocity, session 11.21.22.51.4-1.4-1.1-1.2-1.20.8-1.6-0.5-0.5-0.5-0.61.5-1.60.8
Locomotion distance, session 11.21.54.41.3-1.7-0.8-0.9-0.90.5-2.10.20.20.1-0.31.6-1.81.9
Locomotion velocity, session 24.75.59.62.9-3.1-2.5-2.5-2.52.2-3.1-1.6-1.6-1.7-1.82.7-2.60.8
Locomotion distance, session 22.94.09.12.4-2.8-2.0-2.0-2.01.6-3.0-1.0-1.0-1.0-1.32.4-2.41.4
Locomotion velocity, session 34.65.48.22.5-2.1-2.5-2.5-2.52.7-1.5-2.8-2.8-2.9-2.51.4-1.3-1.7
Locomotion distance, session 30.00.00.1-0.20.30.10.10.1-0.10.40.00.00.00.1-0.20.2-0.3
Stereotopy head waving bouts, day 34.35.16.72.6-2.6-2.5-2.5-2.52.5-2.3-2.3-2.3-2.3-2.12.0-1.9-0.6
Stereotopy head waving duration, day 34.95.87.62.7-2.6-2.6-2.6-2.62.8-2.2-2.6-2.6-2.7-2.41.9-1.8-1.0
Locomotion velocity, session 70.60.71.20.9-0.5-1.1-1.1-1.10.8-0.4-0.9-0.8-0.7-0.41.0-0.9-0.6
Locomotion distance, session 70.40.51.5-0.71.10.60.60.6-0.41.20.10.10.20.2-0.90.9-0.9
Stereotopy head waving bouts, day 70.50.61.60.5-0.9-0.6-0.5-0.50.1-1.20.20.20.10.41.2-1.21.2
Stereotopy head waving duration, day 70.91.12.71.0-1.3-1.0-1.0-1.00.5-1.6-0.1-0.1-0.20.11.7-1.61.1
Locomotion velocity, session 81.72.04.71.5-1.9-1.4-1.4-1.40.8-2.2-0.4-0.4-0.4-0.32.0-2.11.4
Locomotion distance, session 80.20.41.00.7-0.9-0.5-0.5-0.50.4-1.0-0.2-0.2-0.2-0.40.7-0.70.6
Degree of sensitization distance0.30.30.4-0.50.50.50.50.5-0.60.40.60.60.70.6-0.30.30.4
Degree of sensitization stereotypy1.31.43.0-1.00.60.90.90.9-1.40.11.71.71.61.70.2-0.31.7
Conditioned locomotion2.22.54.2-1.82.01.91.81.8-1.42.10.91.00.91.0-2.01.9-0.5
Cocaine response after cond. corrected6.06.810.6-3.13.32.92.92.9-2.63.22.02.12.02.2-2.72.6-0.3
Cocaine response after cond. not corrected6.57.211.4-3.23.43.13.03.0-2.73.32.12.12.12.2-2.92.8-0.4
Cocaine response before conditioning0.50.60.91.0-0.8-0.9-0.9-0.90.8-0.8-0.7-0.7-0.6-0.70.8-0.8-0.1
Saline control response0.10.10.3-0.40.30.40.40.4-0.20.40.20.20.20.1-0.50.5-0.1
Bone: connectivity density0.71.04.00.3-0.7-0.3-0.4-0.4-0.5-1.31.01.00.80.91.5-1.42.0
Bone: cortical apparent density0.60.81.1-1.00.91.01.01.0-1.00.71.11.01.01.0-0.70.60.5
Bone: cortical area0.50.72.2-0.30.10.10.10.1-0.9-0.41.11.21.11.20.8-0.91.5
Bone: cortical porosity0.80.91.41.1-1.2-1.1-1.1-1.10.8-1.2-0.6-0.6-0.6-0.61.1-1.20.3
Bone: cortical porosity0.60.71.70.8-1.0-0.7-0.7-0.70.2-1.30.20.10.10.11.1-1.31.2
Bone: cortical thickness0.71.12.3-0.90.71.00.90.9-1.30.31.41.51.51.4-0.10.01.3
Bone: cortical thickness0.30.31.1-0.50.80.30.40.4-0.11.0-0.3-0.3-0.2-0.1-0.70.8-1.1
Bone: cortical tissue density0.40.60.8-0.90.70.80.80.8-0.80.60.90.80.80.8-0.60.60.4
Condit. Reinf. active minus inactive responses3.33.75.12.1-1.9-2.1-2.1-2.12.3-1.5-2.1-2.2-2.3-2.01.4-1.2-1.1
Condit. Reinf. active-inactive response ratio1.41.63.01.1-0.8-1.2-1.2-1.21.5-0.4-1.6-1.7-1.7-1.50.3-0.2-1.5
Condit. Reinf. active responses3.64.46.42.5-2.5-2.3-2.3-2.32.3-2.4-1.9-1.9-2.0-2.02.0-1.8-0.2
Condit. Reinf. inactive responses1.51.84.21.6-1.9-1.3-1.4-1.41.1-2.0-0.7-0.6-0.7-0.81.7-1.60.9
Incentive salience index mean2.22.74.01.9-2.0-1.8-1.8-1.81.7-1.9-1.4-1.4-1.5-1.41.7-1.5-0.1
Condit. Reinf. lever presses1.01.33.70.9-1.5-0.7-0.8-0.80.2-1.90.40.30.30.21.7-1.71.9
Condit. Reinf. active minus inactive responses1.51.93.71.1-0.7-1.3-1.3-1.31.7-0.2-1.9-1.9-1.9-1.70.2-0.1-1.9
Condit. Reinf. active-inactive response ratio0.60.62.1-0.40.60.30.40.40.21.0-0.6-0.6-0.7-0.6-1.21.3-1.4
Condit. Reinf. active responses1.62.23.41.5-1.1-1.7-1.7-1.71.7-0.7-1.8-1.8-1.8-1.50.9-0.8-1.5
Condit. Reinf. inactive responses1.11.42.21.4-1.0-1.5-1.5-1.51.2-0.8-1.1-1.1-1.1-0.81.3-1.3-0.6
Condit. Reinf. lever presses1.62.24.11.3-0.9-1.4-1.4-1.41.8-0.3-2.0-2.0-1.9-1.80.4-0.3-1.8
Condit. Reinf. lever reinforcers received1.11.62.81.1-0.6-1.4-1.3-1.31.5-0.2-1.6-1.7-1.7-1.30.5-0.4-1.7
Conditioned reinforcement - actives1.81.82.81.5-1.3-1.6-1.7-1.51.6-1.0-1.4-1.3-1.3-1.51.0-0.9-0.9
Conditioned reinforcement - inactives0.70.71.2-1.01.11.00.91.0-0.81.10.60.80.70.5-1.00.9-0.2
Conditioned locomotion5.66.89.72.8-2.5-3.1-3.0-2.83.1-1.8-2.9-2.8-2.9-2.91.7-1.5-1.9
Patch foraging indifference point 0 sec0.10.10.4-0.30.10.20.20.2-0.4-0.10.50.50.50.60.2-0.10.6
Patch foraging indifference point AUC0.60.71.70.9-0.7-0.8-0.8-0.71.0-0.4-1.0-1.0-0.9-1.30.2-0.0-0.9
Delay disc. indifference point, 0s delay4.95.311.6-1.90.92.01.92.0-2.7-0.03.23.23.03.10.1-0.33.4
Delay disc. indifference point, 16s delay0.10.10.4-0.40.30.20.40.2-0.40.20.40.60.40.5-0.0-0.00.3
Delay disc. indifference point, 2s delay4.24.69.3-2.21.62.12.02.1-2.60.92.82.82.63.0-0.60.42.2
Delay disc. indifference point, 24s delay0.70.71.0-1.01.00.81.00.8-0.90.90.70.81.00.9-0.60.50.1
Delay disc. indifference point, 4s delay0.90.93.2-0.90.50.60.70.6-1.10.11.21.41.01.80.3-0.51.3
Delay disc. indifference point, 8s delay1.11.22.0-1.31.41.21.31.2-1.21.31.00.90.91.0-1.00.90.1
Indifference point function ln k0.20.31.0-0.80.70.40.40.4-0.60.60.60.60.41.0-0.20.10.1
Indifference point function log k0.20.31.0-0.80.70.40.40.4-0.60.60.60.60.41.0-0.20.10.1
Patch foraging total patch changes 0 sec0.10.10.2-0.30.20.20.20.2-0.40.10.40.40.40.50.00.00.4
Patch foraging total patch changes 12 sec0.60.81.9-1.01.01.01.11.1-0.71.10.40.40.60.1-1.31.4-0.4
Patch foraging total patch changes 18 sec0.81.11.71.1-1.0-1.1-1.1-1.11.2-0.7-1.2-1.3-1.1-1.30.5-0.4-0.7
Patch foraging total patch changes 24 sec0.10.10.20.3-0.3-0.2-0.2-0.30.3-0.3-0.3-0.3-0.2-0.50.10.0-0.1
Patch foraging total patch changes 6 sec0.20.40.50.7-0.7-0.7-0.6-0.70.6-0.6-0.6-0.6-0.5-0.70.5-0.4-0.1
Patch foraging time to switch 0 sec1.01.56.0-0.5-0.11.00.80.8-1.3-0.71.61.71.71.30.3-0.52.5
Patch foraging water rate 0 sec0.60.93.6-0.91.30.30.50.6-0.11.7-0.3-0.5-0.40.0-1.21.2-1.9
Patch foraging water rate 12 sec1.92.96.2-2.02.31.81.91.8-1.42.50.80.70.91.0-2.22.2-1.1
Patch foraging water rate 18 sec1.92.58.6-1.21.80.70.91.00.12.5-0.8-1.0-0.9-0.5-2.22.4-2.9
Patch foraging water rate 24 sec2.43.38.4-1.92.41.51.71.7-0.82.90.1-0.1-0.00.2-2.62.6-2.3
Patch foraging water rate 6 sec0.71.05.0-0.40.90.00.10.20.51.4-1.0-1.1-0.9-0.7-1.21.1-2.2
Seeking ratio, delayed vs. immediate footshock4.04.66.32.4-2.3-2.5-2.5-2.52.4-2.0-2.1-2.2-2.1-2.02.0-1.8-0.8
Distance traveled before self-admin0.30.30.9-0.40.20.20.30.4-0.6-0.00.90.90.90.70.1-0.20.8
Distance traveled after self-admin0.60.71.40.9-1.0-1.2-0.9-0.90.9-0.9-0.7-0.7-0.6-0.70.9-0.8-0.2
Extensor digitorum longus weight4.417.423.1-4.84.74.64.74.7-4.64.14.04.14.13.9-3.93.61.1
Bone: elastic displacement0.20.30.40.6-0.6-0.6-0.7-0.70.6-0.5-0.5-0.5-0.4-0.40.5-0.5-0.1
Bone: elastic work0.20.20.7-0.20.20.10.00.0-0.5-0.00.60.60.60.80.3-0.50.7
Bone: endosteal estimation0.10.30.9-0.40.20.20.30.3-0.6-0.10.80.80.70.90.4-0.30.8
Bone: endosteal perimeter0.51.02.41.0-1.1-1.2-1.2-1.20.7-1.2-0.4-0.4-0.6-0.21.6-1.40.4
Epididymis fat weight0.20.41.00.3-0.2-0.2-0.2-0.10.70.0-0.8-0.8-0.9-1.0-0.40.5-0.9
Delta time in closed arm before/after self-admin2.72.66.1-1.82.11.61.61.7-0.92.50.40.40.40.3-2.32.4-1.6
Delta time in open arm before/after self-admin0.70.71.2-0.60.60.80.90.9-1.10.21.11.01.10.9-0.20.11.1
Diff in mean of infusions in LGA sessions1.31.52.31.3-1.2-1.2-1.1-1.41.5-0.9-1.4-1.5-1.5-1.20.6-0.6-0.8
Delay discount exponential model param1.61.73.51.5-1.2-1.2-1.3-1.21.6-0.9-1.5-1.7-1.5-1.90.4-0.3-1.0
Extinction: sum of active levers before priming0.80.82.60.4-0.3-0.6-0.7-0.51.10.2-1.2-1.2-1.1-1.2-0.50.7-1.6
Active lever presses in extinction session 62.32.23.31.5-1.6-1.8-1.7-1.71.8-1.3-1.6-1.6-1.4-1.41.2-1.1-0.8
Bone: final force0.81.32.7-0.80.70.80.80.8-1.40.21.61.61.51.60.3-0.41.6
Bone: final moment0.61.02.2-0.70.60.70.60.6-1.30.11.41.51.41.50.4-0.41.4
Food consumed during 24 hour testing period0.50.61.2-1.10.90.80.80.8-0.90.80.90.70.71.1-0.50.70.2
Glucose1.21.82.5-1.61.41.41.51.5-1.51.21.41.41.41.4-1.01.00.6
Heart weight0.30.41.40.20.1-0.3-0.2-0.20.60.4-0.8-0.8-0.9-0.9-0.40.5-1.2
Delay discount hyperbolic model param2.22.34.81.7-1.4-1.5-1.5-1.41.9-1.0-1.8-2.0-1.8-2.20.5-0.4-1.2
Intermittent access intake day 1-15 change5.04.97.22.3-1.9-2.5-2.4-2.42.7-1.3-2.7-2.7-2.5-2.51.2-1.1-1.9
Intermittent access intake escalation4.34.27.51.8-1.3-2.1-2.0-1.92.5-0.5-2.7-2.7-2.6-2.60.4-0.2-2.7
Intermittent access intake escalation 25.45.39.92.2-1.4-2.2-2.2-2.12.8-0.6-3.1-3.1-2.9-3.00.4-0.2-2.9
Intermitt. access day 1 inactive lever presses0.20.31.6-0.10.3-0.3-0.2-0.00.40.6-0.5-0.5-0.4-0.4-0.40.5-1.3
Intermitt. access day 15 inactive lever presses0.30.40.90.6-0.3-0.5-0.5-0.50.7-0.1-0.9-0.8-0.8-0.90.1-0.0-0.8
Intermitt. access escalation Index0.50.41.60.2-0.4-0.1-0.1-0.3-0.3-0.70.80.60.80.50.8-0.91.3
Intermittent access day 1 total infusions0.00.00.1-0.20.10.10.00.1-0.20.00.20.40.10.40.1-0.10.2
Intermittent access day 15 total infusions1.31.52.71.1-0.8-1.2-1.3-1.21.5-0.3-1.7-1.5-1.6-1.50.4-0.2-1.5
Intermittent access terminal intake (last 3 days)0.80.91.50.9-0.7-1.0-1.1-1.01.1-0.4-1.2-1.0-1.0-1.10.5-0.4-1.0
Intermittent access total infusions0.10.10.40.2-0.2-0.4-0.5-0.30.50.0-0.5-0.4-0.5-0.50.1-0.0-0.6
Intermittent access day 1 locomotion0.30.30.50.5-0.4-0.5-0.6-0.50.6-0.2-0.7-0.6-0.7-0.70.2-0.2-0.6
Intermittent access day 15 total locomotion2.62.84.61.8-1.5-1.9-1.8-1.62.1-1.0-2.0-1.9-1.9-2.10.9-0.7-1.4
Intermittent access total locomotion0.80.91.41.0-0.9-1.2-1.2-1.01.1-0.7-1.0-0.8-0.9-1.10.7-0.6-0.6
Intermittent access standard deviation2.02.13.71.4-0.9-1.6-1.5-1.31.8-0.4-1.9-1.7-1.7-1.90.5-0.3-1.8
Left kidney weight0.10.30.90.7-0.7-0.5-0.6-0.60.3-0.9-0.1-0.00.0-0.20.8-0.90.6
Right kidney weight1.23.44.92.2-1.8-2.1-2.1-2.12.1-1.5-2.0-1.9-1.9-2.01.4-1.4-0.9
Cocaine induced anxiety1.11.22.51.4-1.5-1.2-1.2-1.20.9-1.6-0.7-0.4-0.4-0.81.4-1.40.6
Post-drug Anxiety1.01.12.41.3-1.4-1.0-1.0-1.00.7-1.5-0.7-0.5-0.5-0.51.4-1.40.9
Baseline Anxiety0.20.20.7-0.00.30.10.10.10.20.5-0.6-0.6-0.6-0.4-0.50.6-0.9
Tail length2.26.610.52.7-2.1-2.8-2.8-2.73.1-1.3-3.2-3.2-3.1-3.01.2-1.1-2.4
Length with tail1.76.28.72.9-2.5-2.8-2.9-2.92.7-2.1-2.6-2.5-2.4-2.42.1-2.1-1.0
Length without tail0.41.02.41.0-1.2-0.9-1.0-0.90.4-1.5-0.0-0.0-0.1-0.01.5-1.61.1
Times rat made contact with spout0.50.51.2-0.91.00.70.80.8-0.51.10.30.30.30.4-1.01.1-0.6
Lifetime Intake0.00.10.10.2-0.1-0.3-0.4-0.20.3-0.0-0.3-0.1-0.3-0.30.1-0.1-0.3
Liver weight, left2.43.85.6-2.22.02.42.42.3-2.11.81.81.81.81.6-1.91.90.7
Liver weight, right1.32.23.2-1.51.21.71.71.8-1.70.91.71.81.81.3-0.90.91.2
Locomotor activity3.86.08.62.8-2.8-2.9-2.9-2.92.4-2.7-2.1-2.0-1.9-1.92.7-2.6-0.1
Locomotor testing distance2.13.45.02.1-2.1-2.2-2.2-2.21.9-1.9-1.7-1.6-1.6-1.51.9-1.8-0.3
Locomotor testing rearing0.10.10.6-0.20.40.00.10.00.10.6-0.4-0.3-0.3-0.2-0.30.3-0.8
Locomotion in novel chamber0.20.30.90.2-0.1-0.2-0.2-0.10.60.2-0.6-0.6-0.5-1.0-0.40.6-0.9
Locomotion in novel chamber post-restriction0.50.71.30.7-0.5-0.9-1.0-0.90.9-0.3-1.0-1.0-1.1-0.60.5-0.4-0.9
Fecal boli incidents, locomotor time 11.82.03.0-1.21.51.71.71.7-1.41.41.21.41.70.2-1.71.50.3
Change in fecal boli incidents, locomotor task0.70.72.20.4-0.7-1.0-1.1-1.00.4-0.8-0.3-0.3-0.10.61.5-1.40.3
Time >=10cm from walls, locomotor time 10.40.41.50.0-0.20.10.10.1-0.5-0.50.70.91.20.60.6-0.71.2
Bouts of movement, locomotor time 10.10.10.30.3-0.1-0.3-0.3-0.30.40.0-0.5-0.4-0.5-0.40.10.0-0.5
Total resting periods, locomotor time 10.20.20.30.5-0.3-0.5-0.5-0.50.5-0.2-0.5-0.4-0.5-0.40.3-0.2-0.4
Rest time, locomotor task time 10.20.20.40.6-0.7-0.5-0.6-0.50.5-0.6-0.3-0.2-0.4-0.40.5-0.50.0
Distance moved, locomotor task time 10.50.61.8-0.3-0.10.10.20.1-0.6-0.50.80.81.11.30.7-0.91.3
Vertical activity count, locomotor time 10.20.20.6-0.60.70.30.20.3-0.40.80.20.10.30.6-0.30.3-0.4
Time >=10cm from walls, locomotor time 21.21.32.0-1.21.41.21.31.2-1.21.31.00.91.20.8-1.11.00.1
Bouts of movement, locomotor time 21.01.02.21.3-1.4-1.0-1.0-1.00.8-1.5-0.3-0.5-0.7-0.61.3-1.40.7
Total resting periods, locomotor time 21.01.02.31.3-1.4-1.0-0.9-1.00.7-1.5-0.3-0.4-0.7-0.51.3-1.40.8
Rest time, locomotor task time 20.70.81.31.1-1.1-1.0-0.9-1.00.8-1.1-0.7-0.5-0.7-0.61.0-1.10.2
Distance moved, locomotor task time 20.81.01.6-1.21.11.11.11.1-1.01.10.80.70.80.8-1.11.1-0.0
Vertical activity count, locomotor time 21.31.42.7-1.41.51.31.21.3-1.01.60.70.60.70.5-1.51.5-0.6
Light reinforcement 15.19.313.03.6-3.3-3.3-3.3-3.43.5-2.8-3.2-3.2-3.2-3.52.2-2.1-1.2
Light reinforcement 21.92.63.82.0-1.8-1.7-1.8-1.81.8-1.6-1.6-1.6-1.6-1.71.3-1.3-0.4
Bone: marrow area0.10.30.9-0.40.20.30.30.3-0.7-0.00.80.80.70.90.3-0.20.8
Bone: maximum diameter1.22.14.21.6-1.7-1.7-1.7-1.71.2-1.8-0.8-0.8-0.8-0.62.1-1.90.6
Bone: maximum force0.81.32.9-1.00.90.90.90.9-1.50.51.51.61.51.70.1-0.11.3
Bone: maximum moment0.61.12.4-0.90.80.80.80.8-1.30.41.41.51.41.50.2-0.21.3
Mean time between licks in bursts3.04.26.92.1-1.7-2.1-2.1-2.12.5-1.1-2.6-2.6-2.6-2.60.8-0.7-1.9
Mean num. licks in bursts0.10.10.20.1-0.1-0.0-0.0-0.0-0.2-0.20.30.30.40.30.3-0.40.5
Cd content in liver0.10.10.2-0.30.20.30.30.3-0.50.10.50.50.50.5-0.0-0.00.5
Co content in liver0.40.40.90.7-0.5-0.7-0.6-0.60.8-0.3-0.8-0.8-0.9-0.90.2-0.1-0.7
Cu content in liver0.30.41.50.3-0.5-0.3-0.2-0.2-0.2-0.80.50.60.60.50.9-1.01.2
Fe content in liver0.10.10.3-0.00.20.20.10.10.10.4-0.2-0.3-0.3-0.4-0.50.5-0.6
K content in liver0.50.51.40.5-0.8-0.5-0.4-0.40.1-1.10.40.30.30.11.0-1.01.2
Mg content in liver0.50.51.60.5-0.8-0.5-0.5-0.50.0-1.10.40.30.40.31.1-1.21.3
Mn content in liver2.93.37.62.0-2.3-1.9-2.0-2.01.1-2.6-0.4-0.5-0.5-0.32.7-2.81.5
Na content in liver0.70.82.8-0.30.00.50.50.5-0.9-0.41.41.21.20.90.3-0.41.7
Rb content in liver0.50.62.70.0-0.40.00.00.0-0.6-0.81.00.90.90.90.9-1.01.6
Se content in liver0.20.20.30.6-0.5-0.5-0.5-0.50.5-0.5-0.2-0.4-0.4-0.50.4-0.4-0.0
Sr content in liver0.40.41.0-0.30.70.40.40.4-0.00.9-0.2-0.3-0.3-0.4-0.91.0-1.0
Zn content in liver1.51.76.30.40.1-0.6-0.5-0.51.30.7-1.6-1.7-1.8-1.7-0.91.1-2.5
Bone: minimum diameter0.10.30.90.2-0.4-0.4-0.4-0.4-0.1-0.60.30.30.20.51.0-0.90.7
Time in familiar zone, hab. session 11.61.52.91.1-0.7-1.2-1.2-1.21.4-0.3-1.7-1.7-1.7-1.40.5-0.3-1.4
Time in novel zone, hab. session 10.80.82.3-0.50.10.50.40.4-0.9-0.31.31.31.31.30.5-0.61.5
Total zone transitions, hab. session 11.62.24.81.8-2.1-1.5-1.6-1.61.2-2.2-0.7-0.8-0.8-0.91.8-1.91.0
Total locomotion distance, hab. session 12.63.78.12.2-2.5-1.9-2.0-2.01.3-2.8-0.7-0.7-0.7-0.72.7-2.71.6
Locomotion velocity, hab. session 12.63.77.82.3-2.6-2.0-2.0-2.01.6-2.8-1.1-1.1-1.0-1.22.4-2.41.2
Time in familiar zone, hab. session 24.34.48.02.0-1.4-2.0-2.0-2.02.5-0.7-2.8-2.8-2.8-2.60.6-0.4-2.5
Time in novel zone, hab. session 23.23.25.9-1.61.11.61.61.6-2.20.52.42.42.42.4-0.2-0.02.2
Total zone transitions, hab. session 21.01.35.80.7-1.3-0.2-0.3-0.3-0.2-1.90.80.80.70.31.3-1.42.4
Total locomotion distance, hab. session 21.72.25.01.9-2.1-1.4-1.4-1.41.2-2.2-0.8-0.8-0.8-1.21.7-1.71.0
Locomotion velocity, hab. session 22.02.76.82.0-2.4-1.5-1.5-1.51.2-2.6-0.7-0.7-0.7-1.11.9-2.01.4
Novel to familiar place preference ratio2.93.05.9-1.40.81.41.41.4-2.00.12.42.42.42.40.1-0.32.4
Novelty place preference1.81.84.3-1.00.51.01.01.0-1.5-0.11.91.91.91.90.3-0.42.1
Time in novel zone, NPP test2.02.14.2-1.20.71.21.11.1-1.70.12.02.02.02.00.1-0.32.0
Total zone transitions, NPP test0.40.52.20.7-1.1-0.2-0.3-0.30.1-1.40.20.20.2-0.30.7-0.81.5
Total locomotion distance, NPP test0.50.72.80.7-1.1-0.3-0.3-0.30.0-1.50.40.40.40.01.0-1.11.7
Locomotion velocity, NPP test0.60.82.71.0-1.3-0.6-0.6-0.60.3-1.60.10.10.1-0.31.2-1.21.5
Intraocular pressure0.81.13.1-0.71.20.70.70.7-0.01.6-0.5-0.5-0.5-0.6-1.61.7-1.8
Delta distance traveled before/after self-admin1.41.52.21.4-1.2-1.3-1.2-1.41.4-1.0-1.5-1.5-1.3-1.30.9-0.8-0.7
Delta ambulatory time before/after self-admin1.61.72.31.5-1.4-1.5-1.3-1.51.5-1.2-1.4-1.4-1.4-1.31.1-1.0-0.5
Parametrial fat weight0.30.51.00.6-0.4-0.8-0.8-0.70.9-0.1-1.0-0.9-0.8-0.80.4-0.2-1.0
Pavlov. Cond. lever latency0.40.51.6-0.50.80.40.40.4-0.01.1-0.3-0.3-0.3-0.4-1.11.1-1.3
Pavlov. Cond. magazine entry latency2.22.84.31.7-1.5-1.7-1.7-1.72.0-1.1-2.1-2.0-2.1-2.00.8-0.7-1.3
Pavlov. Cond. change in total contacts0.10.10.10.3-0.4-0.3-0.3-0.30.3-0.4-0.2-0.2-0.2-0.20.2-0.20.1
Pavlov. Cond. index score0.60.71.41.0-1.1-0.9-0.9-0.90.8-1.2-0.6-0.6-0.6-0.51.1-1.00.4
Pavlov. Cond. latency score0.81.02.21.1-1.4-1.0-1.1-1.10.8-1.5-0.5-0.5-0.5-0.31.4-1.30.7
Pavlov. Cond. lever contacts0.70.82.10.7-1.1-0.7-0.7-0.70.2-1.40.20.10.10.21.4-1.41.3
Pavlov. Cond. magazine entry number0.50.71.0-0.90.90.80.80.8-1.00.71.01.01.00.9-0.50.40.4
Pavlov. Cond. intertrial magazine entries0.30.31.2-0.00.40.10.10.10.30.6-0.5-0.5-0.6-0.7-0.70.8-1.1
Pavlov. Cond. lever-magazine prob. diff.0.91.11.71.2-1.3-1.1-1.1-1.11.0-1.3-0.9-0.9-0.9-0.71.2-1.10.1
Pavlov. Cond. response bias0.91.11.51.2-1.1-1.1-1.1-1.11.2-0.9-1.2-1.2-1.2-1.20.7-0.6-0.5
Pavlov. Cond. lever latency0.70.91.4-1.10.71.21.21.2-1.00.51.21.11.00.8-0.80.90.8
Pavlov. Cond. magazine entry latency0.40.50.90.7-0.6-0.9-0.8-0.80.7-0.5-0.8-0.7-0.6-0.50.8-0.7-0.4
Pavlov. Cond. change in total contacts0.60.81.30.9-0.6-1.0-1.0-1.01.0-0.3-1.1-1.1-1.1-0.80.5-0.6-0.9
Pavlov. Cond. index score0.70.91.41.0-0.6-1.2-1.1-1.11.0-0.4-1.2-1.1-1.0-0.80.7-0.8-0.9
Pavlov. Cond. latency score0.70.91.41.1-0.8-1.2-1.2-1.21.0-0.6-1.1-1.0-0.9-0.70.9-1.0-0.6
Pavlov. Cond. lever contacts0.50.71.40.8-0.4-0.9-0.9-0.90.9-0.1-1.2-1.1-1.0-0.80.4-0.5-1.1
Pavlov. Cond. magazine entry number0.70.81.5-0.90.81.21.11.1-0.90.61.00.90.90.6-1.00.90.5
Pavlov. Cond. intertrial magazine entries0.50.71.2-0.91.00.90.90.9-0.71.10.40.40.40.5-1.11.0-0.4
Pavlov. Cond. lever-magazine prob. diff.0.81.01.51.1-0.8-1.2-1.2-1.21.0-0.6-1.2-1.1-1.0-0.80.9-0.9-0.7
Pavlov. Cond. response bias1.31.83.11.3-0.8-1.5-1.4-1.41.5-0.4-1.8-1.7-1.6-1.40.7-0.7-1.5
Time in closed arm before self-admin0.70.83.6-0.1-0.30.40.30.3-0.8-0.81.21.21.10.90.6-0.81.9
Time in closed arm after self-admin0.00.00.1-0.00.10.10.1-0.00.10.2-0.1-0.2-0.2-0.2-0.20.3-0.3
Time in open arm before self-admin0.50.51.00.5-0.5-0.9-0.8-0.81.0-0.2-0.9-0.8-0.9-0.60.3-0.2-1.0
Time in open arm after self-admin0.60.60.9-0.90.80.80.90.9-0.90.70.90.90.80.9-0.60.50.4
Bone: periosteal estimation0.30.72.4-0.2-0.1-0.00.00.0-0.7-0.61.11.11.01.21.0-1.01.5
Bone: periosteal perimeter0.50.82.60.8-0.9-1.0-1.0-1.00.3-1.20.00.1-0.10.31.6-1.50.9
Bone: post-yield work0.50.60.9-0.91.00.80.90.9-0.90.80.80.90.70.8-0.50.60.2
Progressive ratio test 1 active lever presses0.20.20.4-0.50.60.50.40.5-0.30.70.20.30.10.1-0.50.5-0.4
Progressive ratio test 1 breakpoint0.20.20.5-0.60.70.60.50.6-0.40.70.30.40.20.2-0.50.5-0.2
Progressive ratio test 1 inactive lever presses0.00.00.10.2-0.1-0.1-0.2-0.10.1-0.1-0.00.1-0.1-0.30.2-0.2-0.0
Progressive ratio test 2 active lever presses0.20.21.0-0.00.2-0.2-0.2-0.00.40.5-0.5-0.4-0.4-0.4-0.30.4-1.0
Progressive ratio test 2 breakpoint0.10.20.40.3-0.2-0.5-0.5-0.30.50.0-0.5-0.4-0.4-0.50.2-0.1-0.7
Progressive ratio test 2 inactive lever presses0.10.10.20.2-0.3-0.3-0.4-0.20.2-0.3-0.20.0-0.0-0.20.3-0.30.0
Incentive Sensitization - Responses0.20.21.1-0.10.2-0.3-0.20.00.40.5-0.4-0.4-0.2-0.4-0.40.5-1.1
Incentive Sensitization - Breakpoint0.20.21.00.00.1-0.4-0.3-0.10.40.4-0.5-0.5-0.3-0.4-0.20.4-1.0
Sum of active levers in priming session hrs 5-60.00.00.0-0.0-0.10.00.00.00.0-0.10.00.10.1-0.1-0.10.00.0
Progressive ratio0.40.51.2-0.70.60.90.91.0-0.50.70.30.30.3-0.0-1.11.1-0.1
Food seeking constrained by brief footshock0.10.20.40.5-0.7-0.2-0.3-0.20.5-0.6-0.3-0.3-0.4-0.60.0-0.10.2
Seeking ratio, punishment vs. effort0.30.40.70.8-0.8-0.7-0.8-0.70.5-0.9-0.2-0.3-0.3-0.30.8-0.90.3
Retroperitoneal fat weight0.31.01.5-1.21.01.21.21.2-1.00.90.90.90.80.8-0.91.00.3
Reaction time number correct1.21.84.0-1.61.81.41.31.3-1.02.00.60.50.40.9-1.71.7-1.1
Reaction time mean minus median0.50.71.30.8-0.5-1.0-0.8-0.80.9-0.3-1.0-1.0-1.1-0.80.6-0.5-0.9
Reaction time mean minus median AUC0.40.51.60.5-0.6-0.6-0.5-0.50.0-0.80.20.20.10.41.2-1.30.9
Reaction time num false alarms0.30.41.5-0.81.10.40.40.4-0.41.20.10.10.10.7-0.70.6-0.9
Reaction time num false alarms AUC0.60.82.4-1.11.30.70.70.7-0.51.50.20.10.10.6-1.11.0-1.1
Reaction time trials correct on left1.21.84.0-1.61.81.41.31.3-1.02.00.60.50.40.9-1.71.7-1.1
Reaction time trials on left1.21.73.7-1.61.81.31.31.3-1.01.90.70.50.40.9-1.61.6-1.0
Reaction time mean0.10.20.80.3-0.3-0.4-0.2-0.3-0.1-0.50.10.20.10.20.9-0.70.6
Reaction time mean AUC0.10.20.80.3-0.3-0.4-0.2-0.2-0.1-0.50.20.30.20.30.9-0.70.7
Median of all reaction times0.20.31.0-0.10.00.10.20.2-0.6-0.30.60.70.70.70.6-0.51.0
Reaction time omissions0.30.40.70.8-0.8-0.8-0.7-0.70.7-0.8-0.4-0.4-0.5-0.60.7-0.70.1
Reaction time false alarm rate0.00.00.2-0.20.30.00.00.0-0.20.30.10.10.10.4-0.0-0.1-0.1
Reaction time premature initiation rate0.81.02.20.8-0.5-0.9-0.8-0.81.2-0.1-1.5-1.4-1.4-1.40.00.1-1.4
Reaction time premature initiations0.71.04.20.00.4-0.3-0.2-0.20.81.0-1.2-1.3-1.3-1.0-0.90.9-2.1
Std. dev. reaction times0.20.30.50.7-0.4-0.7-0.6-0.60.5-0.4-0.5-0.5-0.6-0.40.7-0.7-0.2
Reaction time trials completed1.21.73.7-1.61.81.31.31.3-1.01.90.70.50.40.9-1.61.6-1.0
Reaction time trials AUC1.31.94.5-1.71.91.41.31.4-1.02.10.60.40.30.8-1.81.8-1.2
Run reversals in cocaine runway, females0.40.40.70.6-0.8-0.8-0.8-0.70.6-0.7-0.5-0.5-0.6-0.20.8-0.8-0.0
Run reversals in cocaine runway, males1.31.31.91.2-1.3-1.2-1.4-1.31.2-1.2-1.0-1.0-1.2-0.91.1-1.1-0.1
Latency to leave start box in cocaine runway1.71.83.71.4-1.7-1.7-1.6-1.51.1-1.8-0.7-0.6-0.5-0.41.9-1.80.6
Latency to leave start box in cocaine runway, F1.21.33.40.7-1.3-0.9-1.0-0.70.1-1.70.50.50.70.71.8-1.81.7
Latency to leave start box in cocaine runway, M1.91.94.01.0-0.6-1.3-1.0-1.21.6-0.1-1.9-1.9-1.9-1.8-0.00.2-2.0
Std. dev. time between licks in bursts1.11.32.41.2-1.2-1.4-1.4-1.41.0-1.2-0.8-0.8-0.8-0.31.5-1.50.0
Total sessions with >9 infusions0.10.10.30.1-0.3-0.3-0.4-0.2-0.0-0.40.30.40.30.20.6-0.60.4
Short access day 1 total inactive lever presses0.10.10.50.4-0.3-0.1-0.2-0.10.3-0.2-0.10.0-0.2-0.70.0-0.1-0.1
Short access day 10 total inactive lever presses0.10.10.3-0.10.2-0.00.10.20.10.4-0.2-0.1-0.2-0.3-0.40.5-0.6
Short access day 1 total infusions0.40.50.90.8-0.9-0.6-0.8-0.70.4-1.0-0.20.0-0.1-0.50.9-1.00.6
Short access day 10 total infusions0.00.10.3-0.10.20.0-0.10.10.10.3-0.10.0-0.3-0.2-0.20.2-0.5
Short access total infusions0.00.00.10.1-0.1-0.1-0.2-0.10.0-0.10.10.20.1-0.00.2-0.20.1
Short access day 1 locomotion1.21.32.21.3-1.3-1.4-1.5-1.41.1-1.2-0.9-0.6-0.8-0.91.4-1.3-0.0
Short access day 10 total locomotion2.83.25.11.8-1.4-2.0-2.0-1.92.2-0.9-2.0-2.0-2.1-2.20.9-0.7-1.8
Short access total locomotion0.80.81.51.0-0.9-1.1-1.2-1.11.0-0.7-0.8-0.6-0.8-0.90.9-0.8-0.5
One hour access (0.3 mA shock)0.10.20.4-0.50.40.40.30.5-0.50.40.40.60.30.5-0.20.20.1
Compulsive drug intake0.80.91.8-0.80.50.70.70.8-1.10.11.31.31.31.3-0.1-0.01.2
One hour access (shock baseline)0.10.10.7-0.10.3-0.0-0.10.00.20.5-0.4-0.2-0.5-0.4-0.30.4-0.9
Social response proportion0.91.01.81.4-1.3-0.9-1.0-1.00.9-1.3-0.8-0.7-0.8-1.10.8-0.90.3
Social responses6.68.412.03.5-3.1-3.3-3.4-3.33.1-2.7-2.8-2.8-2.8-2.92.6-2.5-0.9
Social time0.50.61.1-0.80.61.11.01.0-0.80.40.80.90.90.4-0.80.80.7
Soleus weight7.221.229.4-5.14.65.04.94.9-5.43.75.25.25.25.2-3.12.82.7
Bone: stiffness2.13.25.5-1.81.61.71.71.7-2.31.02.32.32.32.4-0.60.51.7
Tibialis anterior weight1.03.44.8-2.11.91.82.02.0-2.11.52.12.12.12.2-1.21.11.0
Time to tail flick, vehicle, before self-admin1.01.02.01.2-1.3-1.1-1.1-1.00.7-1.4-0.4-0.5-0.5-0.41.3-1.40.7
Time to tail flick, vehicle, after self-admin0.50.51.7-0.20.60.40.30.20.20.9-0.6-0.8-0.7-0.7-1.01.1-1.3
Time to tail flick, test, before self-admin0.70.61.50.9-1.0-0.6-0.9-1.00.5-1.2-0.2-0.1-0.2-0.31.1-1.20.8
Time to tail flick, test, after self-admin0.40.40.70.8-0.8-0.6-0.7-0.70.5-0.8-0.3-0.6-0.7-0.40.7-0.80.3
Delta time to tail flick, vehicle, before/after SA1.51.53.7-1.31.61.31.21.2-0.71.80.20.20.20.1-1.81.9-1.2
Delta time to tail flick, test, before/after SA0.20.20.90.10.3-0.10.10.10.30.5-0.5-0.6-0.6-0.6-0.50.6-0.9
Tibia length0.72.03.31.5-1.2-1.5-1.5-1.51.6-0.8-1.8-1.7-1.7-1.60.7-0.7-1.1
Ambulatory time before self-admin0.30.30.7-0.50.20.20.40.4-0.60.10.80.80.80.7-0.0-0.10.6
Ambulatory time after self-admin0.40.40.80.7-0.7-0.9-0.7-0.70.7-0.7-0.5-0.4-0.4-0.60.7-0.6-0.1
Bone: tissue strength1.11.11.9-1.00.81.11.11.1-1.30.51.31.41.41.1-0.40.41.1
Total heroin consumption1.51.82.61.3-1.4-1.5-1.6-1.51.6-1.1-1.5-1.5-1.5-1.21.0-0.8-0.8
Bone: trabecular number1.32.14.41.6-1.8-1.6-1.6-1.61.0-2.0-0.5-0.5-0.6-0.52.1-2.00.9
Bone: trabecular spacing2.33.06.9-1.82.21.71.71.7-0.82.60.10.10.10.2-2.62.6-1.9
Bone: trabecular thickness3.03.69.31.4-2.1-1.5-1.6-1.60.1-2.80.70.70.70.83.0-3.13.0
Bone: trabecular tissue density1.82.53.9-1.81.72.01.91.9-1.61.51.31.41.31.0-1.91.70.3
Water consumed over 24 hours0.50.51.5-0.40.10.30.30.3-0.8-0.21.01.01.01.20.5-0.61.2
Number of responses in last shaping day0.10.10.40.2-0.3-0.5-0.7-0.40.4-0.2-0.3-0.1-0.2-0.30.4-0.4-0.3