Hub : Genes

Itm2b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver mRNA stability Itm2b 0.1 0.05 4.5e-11 0.08 0.08 0.08 0.08 1.8e-09 1.4e-09 2.5e-09 6.2e-09
2 PL mRNA stability Itm2b 0.05 0.03 5.1e-05 0.04 0.03 0.03 0.03 3.7e-05 5.8e-04 1.3e-04 1.1e-04
3 Liver gene expression Itm2b 0.11 0.06 3.0e-10 0.08 0.07 0.06 0.07 6.4e-09 1.1e-08 2.2e-07 2.2e-08
4 IC gene expression Itm2b 0.46 0.14 3.3e-08 0.17 0.15 0.14 0.15 1.3e-07 7.9e-07 2.1e-06 9.8e-07
5 Brain mRNA stability Itm2b 0.21 0.11 4.0e-14 0.12 0.17 0.17 0.18 2.7e-11 2.8e-15 1.1e-15 3.0e-16
6 IL gene expression Itm2b 0.37 0.15 1.2e-06 0.22 0.21 0.22 0.22 6.8e-06 7.3e-06 5.6e-06 4.4e-06
7 Brain gene expression Itm2b 0.58 0.14 0.0e+00 0.34 0.34 0.33 0.34 2.8e-33 1.7e-32 7.7e-32 1.2e-32
8 OFC gene expression Itm2b 0.19 0.11 2.4e-03 0.13 0.06 0.05 0.08 5.2e-04 1.3e-02 2.7e-02 5.1e-03
9 NAcc gene expression Itm2b 0.37 0.12 0.0e+00 0.18 0.19 0.19 0.18 1.3e-26 1.1e-27 2.4e-27 1.1e-26
10 BLA gene expression Itm2b 0.35 0.14 1.5e-08 0.16 0.14 0.18 0.15 1.1e-08 4.4e-08 1.1e-09 3.6e-08
11 Adipose gene expression Itm2b 0.1 0.05 1.2e-11 0.09 0.1 0.09 0.1 2.3e-10 3.2e-11 1.3e-10 6.0e-11
12 PL gene expression Itm2b 0.22 0.08 0.0e+00 0.21 0.24 0.24 0.24 2.0e-22 1.1e-25 9.2e-26 7.2e-26
13 pVTA mRNA stability Itm2b 0.08 0.05 1.0e-05 0.07 0.07 0.07 0.08 1.4e-06 3.1e-06 3.0e-06 6.9e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.00.10.20.4-0.4-0.30.30.0-0.20.2-0.2-0.30.20.20.20.2
Area under the delay curve0.20.31.30.8-0.7-1.1-0.0-0.30.1-0.1-0.90.3-0.00.30.6-0.1
BMI with tail0.10.21.1-0.50.10.70.0-0.20.1-0.11.0-0.2-0.0-0.0-0.50.4
BMI without tail0.20.83.4-1.10.61.60.40.2-0.40.41.8-0.80.2-0.2-1.30.6
Body weight0.10.51.21.1-0.7-0.40.80.7-0.60.6-0.2-0.70.8-1.0-0.80.4
Weight adjusted by age0.72.15.0-0.20.3-0.9-1.7-1.41.5-1.5-1.22.2-1.81.32.0-1.1
Bone surface0.10.30.90.8-0.7-0.90.1-0.40.2-0.2-0.70.0-0.30.30.70.1
Bone volume0.10.20.60.6-0.4-0.80.1-0.2-0.00.0-0.7-0.1-0.10.50.5-0.1
Breakpoint value in progressive ratio session0.20.42.0-0.71.40.0-0.2-0.20.1-0.10.2-0.2-0.20.70.0-1.4
Number of licking bursts0.41.32.50.1-0.10.91.41.1-1.31.30.8-1.61.2-1.1-1.50.8
Context. condit. distance diff. score3.34.09.6-1.80.93.11.41.3-1.71.72.8-2.41.2-1.1-3.11.5
Locomotion velocity, session 11.51.72.7-0.30.7-1.0-1.6-1.31.2-1.2-1.31.6-1.41.51.6-1.5
Locomotion distance, session 10.40.62.11.0-0.6-1.4-0.2-0.10.3-0.3-1.30.6-0.30.41.0-0.5
Locomotion velocity, session 20.40.51.80.7-0.6-1.1-0.3-0.20.1-0.1-1.30.7-0.30.41.2-0.4
Locomotion distance, session 21.21.66.21.7-0.9-2.5-0.3-0.10.5-0.5-2.20.9-0.10.71.8-1.1
Locomotion velocity, session 30.30.41.0-0.80.51.00.20.3-0.60.61.0-0.50.4-0.0-0.50.3
Locomotion distance, session 31.01.12.0-0.70.11.41.01.0-1.21.21.3-1.30.8-0.6-1.40.8
Stereotopy head waving bouts, day 30.50.71.6-0.60.8-0.3-1.0-0.50.8-0.8-0.11.2-0.60.91.2-1.0
Stereotopy head waving duration, day 30.91.12.1-0.30.8-0.9-1.2-0.91.1-1.1-0.81.4-0.61.21.4-1.4
Locomotion velocity, session 77.88.614.6-1.50.33.83.02.8-3.23.23.7-3.62.6-2.2-3.62.7
Locomotion distance, session 74.55.813.5-1.50.53.32.22.0-2.42.43.7-3.01.7-1.6-2.92.0
Stereotopy head waving bouts, day 70.40.52.10.8-0.5-1.1-0.20.2-0.00.0-1.40.70.40.20.9-0.4
Stereotopy head waving duration, day 70.50.62.00.5-0.1-1.0-0.6-0.40.5-0.5-1.41.1-0.10.51.1-0.7
Locomotion velocity, session 80.50.61.1-0.30.20.80.91.0-1.01.00.6-1.11.0-0.4-1.00.3
Locomotion distance, session 81.01.42.70.4-0.60.51.51.5-1.61.60.6-1.61.4-0.8-1.40.9
Degree of sensitization distance1.51.74.9-1.00.52.01.20.9-1.11.12.2-1.50.8-0.7-1.41.1
Degree of sensitization stereotypy0.20.31.40.8-0.5-0.80.20.2-0.30.3-1.20.10.5-0.20.3-0.1
Conditioned locomotion0.30.41.4-1.00.71.2-0.3-0.40.1-0.21.1-0.2-0.6-0.0-0.60.1
Cocaine response after cond. corrected1.11.64.5-2.12.01.4-1.1-1.20.8-0.81.40.5-1.31.00.1-0.9
Cocaine response after cond. not corrected0.30.51.8-1.31.11.0-0.5-0.40.1-0.10.90.1-0.60.6-0.1-0.4
Cocaine response before conditioning2.22.75.32.3-2.3-1.21.62.0-1.71.7-1.4-1.01.8-1.4-0.51.4
Saline control response0.60.82.11.4-0.9-0.91.00.9-0.80.8-0.6-0.90.9-1.0-0.60.2
Bone: connectivity density0.30.41.10.8-0.90.00.70.3-0.40.40.1-0.70.5-0.9-0.51.1
Bone: cortical apparent density0.50.93.3-1.41.21.7-0.0-0.40.1-0.11.8-0.4-0.6-0.3-0.90.1
Bone: cortical area0.10.10.30.4-0.4-0.50.2-0.20.2-0.2-0.30.1-0.20.20.60.1
Bone: cortical porosity1.01.13.71.9-1.7-1.50.40.8-0.50.5-1.50.00.9-0.60.20.6
Bone: cortical porosity0.80.93.31.8-1.6-1.60.20.5-0.30.3-1.50.20.6-0.40.30.3
Bone: cortical thickness0.20.30.90.5-0.60.00.90.6-0.60.60.1-0.70.7-0.7-0.30.6
Bone: cortical thickness0.50.61.7-0.90.71.30.70.3-0.50.51.3-1.00.2-0.3-0.60.3
Bone: cortical tissue density0.60.93.5-1.51.21.80.0-0.40.0-0.01.9-0.5-0.5-0.4-1.00.2
Condit. Reinf. active minus inactive responses0.60.62.41.5-1.2-1.30.10.5-0.20.2-1.10.50.2-0.70.70.2
Condit. Reinf. active-inactive response ratio0.70.71.7-0.50.5-0.1-1.2-1.01.0-1.00.21.2-1.30.60.9-0.6
Condit. Reinf. active responses1.52.05.82.4-2.1-1.51.21.5-1.21.2-1.4-0.41.2-1.50.21.0
Condit. Reinf. inactive responses3.24.28.93.0-2.6-1.62.12.3-2.02.0-1.8-1.42.4-2.1-0.71.5
Incentive salience index mean2.22.88.93.0-2.7-1.91.11.6-1.21.2-1.7-0.11.3-1.80.31.3
Condit. Reinf. lever presses3.65.413.63.7-3.6-1.82.12.5-2.22.2-1.7-1.02.1-2.7-0.52.1
Condit. Reinf. active minus inactive responses0.20.30.90.4-0.70.30.80.5-0.30.30.2-0.40.4-0.8-0.20.9
Condit. Reinf. active-inactive response ratio0.00.10.3-0.1-0.30.30.30.3-0.20.20.1-0.10.2-0.10.00.5
Condit. Reinf. active responses0.50.61.60.6-0.90.41.10.8-0.60.60.4-0.80.8-1.1-0.51.3
Condit. Reinf. inactive responses0.81.32.31.0-1.00.21.51.2-1.11.10.4-1.41.3-1.4-1.01.2
Condit. Reinf. lever presses0.81.14.51.9-2.1-1.30.60.7-0.30.3-1.10.00.7-0.80.41.1
Condit. Reinf. lever reinforcers received0.60.91.90.9-1.10.21.30.9-0.80.80.3-0.91.1-1.2-0.61.4
Conditioned reinforcement - actives0.10.51.9-1.10.71.3-0.0-0.50.2-0.21.4-0.3-0.40.1-0.40.3
Conditioned reinforcement - inactives0.82.24.62.0-2.2-0.81.51.5-1.61.6-0.5-1.01.6-1.6-0.81.7
Conditioned locomotion0.40.61.6-0.30.2-0.4-0.8-1.31.2-1.2-0.30.6-0.71.00.7-0.5
Patch foraging indifference point 0 sec2.05.610.03.1-3.2-1.42.62.7-2.42.4-1.6-1.72.6-2.6-1.12.2
Patch foraging indifference point AUC0.51.33.4-1.81.51.1-0.9-1.30.9-0.91.00.6-1.11.50.6-0.8
Delay disc. indifference point, 0s delay1.11.22.81.1-0.9-1.7-0.9-0.80.9-0.9-1.71.5-0.90.41.5-0.3
Delay disc. indifference point, 16s delay0.10.20.70.5-0.2-0.8-0.0-0.40.2-0.2-0.70.00.10.30.3-0.4
Delay disc. indifference point, 2s delay2.32.54.8-0.10.1-1.2-1.9-1.92.0-2.0-1.12.2-1.71.72.0-1.0
Delay disc. indifference point, 24s delay0.00.10.2-0.40.30.2-0.1-0.40.2-0.20.1-0.1-0.10.40.0-0.2
Delay disc. indifference point, 4s delay0.80.81.3-0.20.2-0.6-1.0-1.11.1-1.1-0.61.1-1.11.01.1-0.7
Delay disc. indifference point, 8s delay0.30.50.90.9-0.8-0.40.90.6-0.90.90.0-0.80.8-0.6-0.50.6
Indifference point function ln k0.61.73.92.0-1.9-0.91.11.4-1.11.1-0.7-0.81.3-1.8-0.91.3
Indifference point function log k0.61.73.92.0-1.9-0.91.11.4-1.11.1-0.7-0.81.3-1.8-0.91.3
Patch foraging total patch changes 0 sec1.85.49.53.1-3.0-1.52.62.8-2.42.4-1.6-1.72.6-2.5-1.12.0
Patch foraging total patch changes 12 sec0.81.12.31.5-1.3-1.01.21.1-1.11.1-1.1-0.71.2-0.70.10.5
Patch foraging total patch changes 18 sec0.51.12.10.3-0.30.41.31.2-1.41.40.5-1.41.4-0.9-1.10.7
Patch foraging total patch changes 24 sec0.41.32.91.7-1.4-0.91.51.1-1.11.1-1.0-1.01.4-1.0-0.30.7
Patch foraging total patch changes 6 sec1.93.36.10.8-1.00.82.52.1-2.12.10.5-2.22.2-2.0-1.91.7
Patch foraging time to switch 0 sec0.00.10.20.2-0.1-0.2-0.3-0.00.2-0.2-0.20.3-0.40.00.3-0.1
Patch foraging water rate 0 sec0.31.02.61.0-0.7-0.31.31.0-1.01.0-0.5-1.31.6-1.1-1.00.6
Patch foraging water rate 12 sec0.00.00.20.1-0.10.1-0.0-0.40.3-0.30.20.1-0.1-0.4-0.10.1
Patch foraging water rate 18 sec0.10.30.9-0.70.51.00.3-0.2-0.00.00.6-0.50.0-0.3-0.90.1
Patch foraging water rate 24 sec1.01.43.0-0.50.61.41.30.9-1.11.11.4-1.71.3-1.1-1.60.7
Patch foraging water rate 6 sec0.20.30.70.10.3-0.7-0.6-0.70.7-0.7-0.70.30.00.50.3-0.8
Seeking ratio, delayed vs. immediate footshock0.20.20.90.5-0.7-0.3-0.5-0.10.3-0.3-0.10.9-0.4-0.40.60.5
Distance traveled before self-admin1.43.04.9-0.10.3-1.5-2.1-2.22.0-2.0-0.52.2-2.01.82.0-1.6
Distance traveled after self-admin1.62.85.6-1.81.70.2-1.9-2.41.9-1.90.71.4-1.92.01.0-1.6
Extensor digitorum longus weight5.421.532.3-2.84.2-1.8-5.5-5.75.5-5.5-1.94.8-4.95.44.1-5.5
Bone: elastic displacement0.30.41.50.9-0.4-1.2-0.10.00.1-0.1-1.00.50.30.10.8-0.5
Bone: elastic work0.91.24.71.6-0.9-2.2-0.2-0.00.3-0.3-2.00.80.30.51.3-0.8
Bone: endosteal estimation0.20.51.00.3-0.4-0.9-0.8-0.60.6-0.6-0.50.8-0.80.91.0-0.3
Bone: endosteal perimeter0.41.02.00.2-0.3-1.0-1.1-1.11.0-1.0-0.81.3-1.31.11.4-0.4
Epididymis fat weight0.21.12.41.3-1.6-0.10.91.1-1.01.0-0.0-0.71.2-1.4-0.71.4
Delta time in closed arm before/after self-admin0.30.31.50.7-1.2-0.20.30.3-0.20.2-0.2-0.00.4-0.4-0.11.1
Delta time in open arm before/after self-admin0.00.00.1-0.20.2-0.1-0.10.3-0.20.20.30.1-0.10.40.3-0.3
Diff in mean of infusions in LGA sessions0.10.20.8-0.20.8-0.00.30.4-0.50.5-0.6-0.40.20.1-0.1-0.9
Delay discount exponential model param0.20.31.3-0.70.61.10.20.5-0.30.30.8-0.40.2-0.5-0.70.2
Extinction: sum of active levers before priming0.40.61.20.6-0.6-0.20.81.0-1.11.1-0.4-0.81.0-0.4-0.40.5
Active lever presses in extinction session 61.01.02.1-0.0-0.00.81.31.1-1.11.10.9-1.51.2-0.8-1.20.6
Bone: final force0.81.22.21.5-1.5-0.41.31.2-1.11.1-0.1-1.01.1-1.3-0.51.2
Bone: final moment0.61.02.91.7-1.6-0.71.00.9-0.80.8-0.3-0.70.9-1.1-0.11.0
Food consumed during 24 hour testing period0.10.21.00.8-1.0-0.80.10.20.0-0.0-0.10.3-0.20.10.50.3
Glucose0.50.83.2-1.51.11.40.4-0.3-0.10.11.8-0.8-0.20.6-0.7-0.1
Heart weight0.00.10.30.1-0.50.0-0.00.1-0.20.2-0.00.2-0.40.10.20.5
Delay discount hyperbolic model param0.30.41.2-0.60.51.10.40.7-0.50.50.8-0.60.4-0.6-0.90.3
Intermittent access intake day 1-15 change0.73.85.91.0-1.00.82.22.4-2.42.40.7-2.32.4-2.2-2.21.6
Intermittent access intake escalation0.73.96.11.3-1.40.62.22.4-2.42.40.4-2.22.5-2.4-2.11.8
Intermittent access intake escalation 20.71.22.00.1-0.51.11.11.0-1.11.11.2-1.21.1-1.3-1.41.3
Intermitt. access day 1 inactive lever presses0.11.32.30.1-0.21.01.41.2-1.31.31.0-1.41.1-1.5-1.31.0
Intermitt. access day 15 inactive lever presses0.31.52.71.2-1.1-0.11.51.6-1.61.60.0-1.21.3-1.4-1.01.0
Intermitt. access escalation Index0.00.10.20.00.1-0.3-0.3-0.10.2-0.2-0.40.2-0.10.20.1-0.5
Intermittent access day 1 total infusions0.30.91.70.9-0.6-0.31.21.2-1.21.2-0.3-1.31.3-0.8-0.80.5
Intermittent access day 15 total infusions1.53.75.61.6-1.60.12.22.4-2.32.30.0-2.12.4-2.2-1.81.8
Intermittent access terminal intake (last 3 days)1.32.23.70.6-0.80.71.71.6-1.81.80.7-1.91.8-1.6-1.71.4
Intermittent access total infusions2.53.05.01.0-1.10.42.12.0-2.12.10.4-2.22.2-1.8-1.81.5
Intermittent access day 1 locomotion1.12.03.21.6-1.5-0.41.71.5-1.51.5-0.2-1.51.8-1.6-1.11.4
Intermittent access day 15 total locomotion0.31.12.00.0-0.10.81.21.3-1.41.40.9-1.41.2-0.9-1.20.7
Intermittent access total locomotion1.11.32.00.9-1.00.11.31.2-1.31.40.3-1.31.4-1.3-1.01.1
Intermittent access standard deviation0.10.31.30.00.7-0.00.70.3-0.70.7-0.1-1.10.7-0.1-0.6-0.7
Left kidney weight0.43.210.52.9-3.2-1.61.21.4-1.41.4-1.4-0.51.7-1.8-0.32.0
Right kidney weight0.53.312.33.5-3.4-2.70.50.4-0.40.4-2.50.30.8-1.30.51.3
Cocaine induced anxiety0.72.05.61.7-1.3-2.4-1.0-0.91.2-1.2-2.31.6-0.70.41.6-0.5
Post-drug Anxiety0.80.92.91.7-1.6-1.5-0.2-0.10.1-0.1-1.30.8-0.0-0.60.80.5
Baseline Anxiety1.11.93.2-0.3-0.21.51.41.5-1.81.81.5-1.51.2-1.2-1.51.5
Tail length0.21.01.61.3-1.0-0.41.11.2-1.11.1-0.3-0.81.0-1.2-0.90.8
Length with tail0.31.14.12.0-1.2-1.50.70.9-0.70.7-1.5-0.30.8-1.2-0.10.0
Length without tail0.20.92.60.9-0.0-1.5-0.6-0.80.7-0.7-1.60.8-0.70.21.1-1.2
Times rat made contact with spout3.23.76.60.6-0.91.12.42.2-2.22.21.6-2.62.2-1.8-2.11.8
Lifetime Intake1.72.14.00.9-0.90.31.81.6-1.81.80.3-2.01.8-1.5-1.61.3
Liver weight, left1.32.36.61.8-0.9-2.6-1.0-0.91.0-1.0-2.41.8-0.90.52.2-1.0
Liver weight, right0.30.52.0-0.51.1-0.3-0.5-0.70.6-0.60.10.1-0.41.00.2-1.4
Locomotor activity4.97.717.12.1-1.1-4.0-2.5-2.32.8-2.8-4.13.2-2.01.83.4-2.2
Locomotor testing distance1.84.513.82.7-1.7-3.7-1.4-1.01.6-1.6-3.72.2-0.90.62.5-1.1
Locomotor testing rearing1.24.615.13.2-2.2-3.9-1.1-0.71.2-1.2-3.91.9-0.40.22.3-0.8
Locomotion in novel chamber0.40.51.31.1-0.9-0.80.50.6-0.60.6-0.8-0.60.9-0.3-0.30.3
Locomotion in novel chamber post-restriction0.10.30.9-0.70.90.3-0.3-0.20.3-0.30.30.1-0.41.00.4-0.8
Fecal boli incidents, locomotor time 10.20.52.10.9-0.0-1.40.20.00.2-0.2-1.5-0.20.20.30.3-1.0
Change in fecal boli incidents, locomotor task0.90.91.9-0.80.50.4-1.4-0.91.0-1.01.11.4-1.30.70.9-0.2
Time >=10cm from walls, locomotor time 10.40.61.81.4-1.2-0.50.40.6-0.20.2-0.9-0.20.8-0.9-0.30.8
Bouts of movement, locomotor time 10.40.61.4-1.01.20.6-0.8-0.91.0-1.0-0.50.3-0.60.50.0-0.8
Total resting periods, locomotor time 10.70.92.0-1.31.40.7-0.9-1.11.2-1.2-0.10.4-0.80.70.2-1.0
Rest time, locomotor task time 10.81.22.3-1.01.50.2-1.2-1.21.3-1.3-0.00.8-1.01.40.8-1.5
Distance moved, locomotor task time 10.61.63.10.6-1.10.71.41.3-1.71.70.4-1.11.3-1.7-1.11.8
Vertical activity count, locomotor time 10.00.30.60.4-0.1-0.7-0.6-0.80.5-0.5-0.50.6-0.50.20.6-0.5
Time >=10cm from walls, locomotor time 20.72.03.7-0.40.8-0.6-1.7-1.71.9-1.9-0.11.6-1.81.31.4-1.4
Bouts of movement, locomotor time 20.30.93.1-1.41.80.6-0.7-0.70.8-0.8-0.10.2-0.61.10.3-1.4
Total resting periods, locomotor time 20.20.72.8-1.21.70.5-0.5-0.50.7-0.7-0.2-0.0-0.40.90.1-1.4
Rest time, locomotor task time 20.20.41.8-0.81.30.60.30.2-0.20.20.4-0.60.20.7-0.3-1.0
Distance moved, locomotor task time 20.50.71.91.2-1.4-0.30.60.6-0.70.7-0.4-0.40.8-1.3-0.41.2
Vertical activity count, locomotor time 20.51.12.00.00.3-1.0-1.4-1.31.2-1.2-0.81.2-1.11.01.1-1.1
Light reinforcement 10.83.54.90.5-1.01.22.22.2-2.12.11.1-2.22.2-1.9-2.22.0
Light reinforcement 21.12.56.8-1.50.62.61.21.0-1.11.12.5-1.80.9-1.0-2.21.3
Bone: marrow area0.20.40.90.4-0.4-0.9-0.7-0.60.6-0.6-0.50.8-0.80.81.0-0.2
Bone: maximum diameter0.30.61.3-0.90.70.2-0.7-1.00.9-0.90.20.7-1.11.10.9-0.5
Bone: maximum force0.30.52.01.4-1.2-1.10.60.4-0.40.4-0.6-0.30.4-0.40.40.3
Bone: maximum moment0.30.62.81.7-1.3-1.40.30.2-0.10.1-0.90.10.2-0.20.80.2
Mean time between licks in bursts0.00.21.40.0-0.40.30.30.5-0.50.51.2-0.30.1-0.2-0.10.6
Mean num. licks in bursts0.00.00.10.1-0.3-0.00.30.10.1-0.10.3-0.40.3-0.0-0.10.3
Cd content in liver1.11.23.60.40.7-1.5-1.0-1.01.2-1.2-0.71.0-0.61.01.2-1.9
Co content in liver3.03.57.8-2.52.80.7-1.7-1.91.8-1.81.31.1-1.92.30.8-2.2
Cu content in liver0.30.31.6-0.80.70.3-0.3-0.50.5-0.51.30.2-0.60.40.2-0.4
Fe content in liver0.30.31.00.3-0.70.40.30.6-0.60.60.6-0.10.2-0.8-0.31.0
K content in liver1.81.83.70.3-1.11.11.41.3-1.51.50.7-1.41.2-1.5-1.61.9
Mg content in liver0.60.61.2-0.2-0.40.90.90.7-0.90.90.9-0.80.4-0.6-0.81.1
Mn content in liver0.20.20.6-0.80.60.5-0.1-0.30.2-0.20.7-0.1-0.20.5-0.4-0.2
Na content in liver1.72.07.32.0-1.6-2.4-0.7-0.40.5-0.5-2.71.40.20.21.6-0.3
Rb content in liver0.10.10.4-0.20.20.50.20.1-0.20.20.4-0.30.1-0.5-0.60.2
Se content in liver2.12.55.91.0-0.5-2.1-1.8-1.11.5-1.5-1.52.4-1.01.22.4-1.1
Sr content in liver1.61.42.4-0.50.7-0.6-1.3-1.41.4-1.40.41.3-1.51.51.4-1.2
Zn content in liver0.20.31.00.4-0.1-1.0-0.2-0.40.3-0.3-0.20.5-0.40.50.9-0.6
Bone: minimum diameter0.30.51.50.8-0.7-1.2-0.1-0.50.7-0.7-0.70.5-0.50.51.2-0.2
Time in familiar zone, hab. session 10.80.91.60.3-0.60.61.11.0-1.11.10.6-1.11.1-0.9-1.31.0
Time in novel zone, hab. session 12.93.26.0-2.12.40.5-1.9-2.01.9-1.90.31.4-2.11.91.4-2.0
Total zone transitions, hab. session 10.30.51.60.30.1-1.0-0.4-0.30.5-0.5-0.80.8-0.50.71.3-0.8
Total locomotion distance, hab. session 10.60.92.71.2-0.8-1.6-0.3-0.00.5-0.5-1.60.9-0.30.31.4-0.3
Locomotion velocity, hab. session 11.21.65.72.1-1.6-2.4-0.20.30.4-0.4-2.40.80.30.01.4-0.2
Time in familiar zone, hab. session 20.80.92.4-1.41.50.7-0.9-1.21.0-1.00.50.3-0.91.0-0.2-1.0
Time in novel zone, hab. session 20.10.10.40.4-0.4-0.40.20.4-0.30.3-0.30.10.1-0.00.60.0
Total zone transitions, hab. session 21.72.24.51.0-0.2-2.1-1.3-1.21.6-1.6-2.01.6-1.41.01.7-1.5
Total locomotion distance, hab. session 21.01.33.11.0-0.3-1.8-0.9-0.71.1-1.1-1.71.1-1.00.61.4-1.0
Locomotion velocity, hab. session 21.51.94.71.1-0.4-2.2-1.2-1.01.3-1.3-2.11.4-1.20.91.7-1.3
Novel to familiar place preference ratio0.91.22.81.2-0.9-0.31.71.5-1.31.3-0.0-1.11.4-1.2-0.40.7
Novelty place preference1.11.42.91.3-1.0-0.41.71.6-1.41.4-0.1-1.11.6-1.3-0.50.8
Time in novel zone, NPP test0.81.02.21.1-0.8-0.31.51.4-1.21.2-0.1-0.91.4-1.0-0.30.6
Total zone transitions, NPP test0.30.51.71.2-0.8-1.30.2-0.10.2-0.2-1.30.1-0.3-0.20.5-0.2
Total locomotion distance, NPP test0.60.82.91.7-1.4-1.20.70.6-0.40.4-1.3-0.50.4-0.80.10.5
Locomotion velocity, NPP test0.71.03.31.8-1.5-1.21.00.8-0.60.6-1.2-0.70.6-1.1-0.20.7
Intraocular pressure0.71.12.30.5-0.30.41.51.4-1.31.30.6-1.31.3-1.1-0.70.7
Delta distance traveled before/after self-admin1.21.34.6-2.12.01.9-0.1-0.50.3-0.31.6-0.5-0.50.6-0.8-0.5
Delta ambulatory time before/after self-admin0.40.82.5-1.51.61.3-0.0-0.40.3-0.31.3-0.5-0.30.4-0.7-0.6
Parametrial fat weight1.12.54.40.9-1.10.72.11.8-1.61.61.0-1.91.9-2.0-1.61.7
Pavlov. Cond. lever latency2.02.54.7-2.22.10.7-1.7-1.71.6-1.60.51.2-1.72.11.0-1.6
Pavlov. Cond. magazine entry latency0.60.81.50.7-0.90.31.20.9-1.01.00.6-0.90.6-1.2-0.91.1
Pavlov. Cond. change in total contacts1.01.13.01.7-1.4-0.91.21.1-0.90.9-0.6-0.71.1-1.3-0.20.7
Pavlov. Cond. index score2.02.64.42.1-2.0-0.51.91.7-1.71.7-0.3-1.41.6-2.1-1.21.6
Pavlov. Cond. latency score2.63.35.62.3-2.3-0.52.12.0-1.91.9-0.3-1.51.9-2.4-1.31.9
Pavlov. Cond. lever contacts2.93.55.92.3-2.3-0.52.12.0-1.91.9-0.4-1.62.0-2.4-1.51.9
Pavlov. Cond. magazine entry number0.30.40.8-0.70.70.1-0.9-0.60.7-0.7-0.20.7-0.40.80.5-0.6
Pavlov. Cond. intertrial magazine entries0.81.03.51.9-1.6-1.30.40.6-0.30.3-1.4-0.11.1-1.00.10.8
Pavlov. Cond. lever-magazine prob. diff.1.72.13.92.0-1.9-0.61.71.5-1.51.5-0.4-1.21.4-1.8-1.01.4
Pavlov. Cond. response bias0.60.71.51.1-1.1-0.21.00.8-0.90.90.1-0.80.6-1.2-0.80.9
Pavlov. Cond. lever latency1.01.44.4-1.81.72.10.40.4-0.80.81.9-1.10.2-0.2-1.3-0.1
Pavlov. Cond. magazine entry latency0.60.82.91.7-1.5-1.70.00.20.0-0.0-1.40.30.6-0.00.50.2
Pavlov. Cond. change in total contacts1.12.64.50.4-0.2-1.7-1.8-1.82.0-2.0-1.32.1-1.71.41.9-1.2
Pavlov. Cond. index score1.01.54.91.7-1.4-2.2-0.7-0.60.9-0.9-2.01.1-0.30.51.3-0.4
Pavlov. Cond. latency score1.01.65.11.8-1.6-2.3-0.7-0.50.8-0.8-2.01.2-0.30.41.3-0.2
Pavlov. Cond. lever contacts1.01.44.61.9-1.7-2.1-0.4-0.40.8-0.8-1.91.0-0.10.21.20.0
Pavlov. Cond. magazine entry number0.40.51.7-1.31.31.30.0-0.2-0.00.00.8-0.2-0.3-0.0-0.4-0.3
Pavlov. Cond. intertrial magazine entries2.14.57.20.7-1.41.42.72.2-2.42.41.2-2.62.2-2.4-2.22.5
Pavlov. Cond. lever-magazine prob. diff.0.81.34.11.5-1.3-2.0-0.8-0.60.9-0.9-1.81.1-0.30.51.2-0.3
Pavlov. Cond. response bias1.11.55.21.9-1.6-2.3-0.4-0.50.9-0.9-1.90.9-0.10.31.3-0.2
Time in closed arm before self-admin0.10.10.5-0.40.20.4-0.3-0.70.5-0.50.10.2-0.50.1-0.10.1
Time in closed arm after self-admin0.10.10.20.1-0.20.20.30.0-0.20.20.1-0.30.3-0.3-0.40.4
Time in open arm before self-admin0.10.20.6-0.30.6-0.2-0.5-0.20.4-0.4-0.50.3-0.20.40.4-0.7
Time in open arm after self-admin0.30.30.7-0.50.2-0.2-0.8-0.30.5-0.50.20.7-0.60.90.6-0.5
Bone: periosteal estimation0.20.41.00.2-0.3-0.7-0.6-0.70.6-0.6-0.40.7-0.80.81.0-0.2
Bone: periosteal perimeter0.20.31.0-0.10.0-0.4-0.5-0.70.6-0.6-0.10.6-0.80.81.0-0.3
Bone: post-yield work0.40.72.5-0.60.21.20.90.5-0.60.61.6-1.20.4-0.3-1.00.7
Progressive ratio test 1 active lever presses0.50.92.3-0.50.51.01.10.8-1.01.01.3-1.50.9-0.5-1.20.3
Progressive ratio test 1 breakpoint0.40.82.0-0.60.61.00.90.6-0.90.91.3-1.40.8-0.3-1.10.2
Progressive ratio test 1 inactive lever presses1.74.58.20.2-0.21.62.72.4-2.52.51.7-2.92.3-2.2-2.51.6
Progressive ratio test 2 active lever presses1.11.53.3-0.40.21.21.51.4-1.41.41.3-1.81.3-0.7-1.50.7
Progressive ratio test 2 breakpoint1.11.43.0-0.20.11.01.41.4-1.41.41.1-1.71.3-0.7-1.40.7
Progressive ratio test 2 inactive lever presses0.72.23.60.7-0.80.51.81.9-1.91.90.8-1.81.7-1.5-1.51.4
Incentive Sensitization - Responses0.20.61.10.0-0.30.61.01.0-0.90.90.5-1.00.9-0.5-0.90.7
Incentive Sensitization - Breakpoint0.30.81.40.2-0.50.51.21.2-1.01.00.4-1.21.1-0.6-1.00.8
Sum of active levers in priming session hrs 5-61.11.03.8-2.01.81.5-0.7-0.80.6-0.60.40.2-0.90.9-0.1-0.6
Progressive ratio0.20.61.8-1.31.41.00.0-0.10.2-0.21.2-0.80.10.4-1.0-0.6
Food seeking constrained by brief footshock3.94.916.4-3.74.02.2-1.3-1.91.4-1.42.10.2-2.02.0-0.4-2.6
Seeking ratio, punishment vs. effort0.40.92.2-0.80.80.3-1.0-1.21.0-1.0-0.21.3-1.50.91.0-0.7
Retroperitoneal fat weight0.52.44.70.8-1.10.91.61.6-1.51.50.9-1.51.7-2.2-1.82.0
Reaction time number correct0.51.85.4-2.32.21.4-1.0-1.31.1-1.11.50.3-1.31.3-0.0-1.1
Reaction time mean minus median0.31.65.51.7-0.9-2.3-0.7-0.50.7-0.7-2.41.2-0.50.21.6-0.9
Reaction time mean minus median AUC0.10.52.41.1-0.6-1.3-0.2-0.10.1-0.1-1.50.5-0.1-0.00.8-0.4
Reaction time num false alarms0.10.10.50.1-0.4-0.3-0.2-0.20.2-0.2-0.30.3-0.30.40.70.3
Reaction time num false alarms AUC0.00.10.30.1-0.5-0.1-0.0-0.10.0-0.0-0.10.2-0.30.30.50.6
Reaction time trials correct on left0.51.85.4-2.32.21.4-1.0-1.31.1-1.11.50.3-1.31.3-0.0-1.1
Reaction time trials on left0.51.75.3-2.32.11.4-0.9-1.21.0-1.01.50.2-1.21.2-0.1-1.1
Reaction time mean0.71.64.21.2-0.9-2.0-1.2-0.70.8-0.8-2.01.7-0.70.61.7-0.6
Reaction time mean AUC0.82.04.71.2-0.7-2.1-1.5-0.91.0-1.0-2.22.0-1.00.81.9-0.9
Median of all reaction times0.71.12.70.8-0.7-1.4-1.3-0.70.8-0.8-1.51.6-0.80.61.4-0.5
Reaction time omissions0.10.20.50.7-0.7-0.20.40.6-0.50.5-0.40.00.1-0.50.30.5
Reaction time false alarm rate0.40.51.81.0-1.4-0.50.70.7-0.70.7-0.6-0.30.6-0.50.11.1
Reaction time premature initiation rate0.30.51.3-1.00.91.1-0.3-0.70.6-0.61.00.2-0.5-0.1-0.4-0.2
Reaction time premature initiations0.61.85.2-2.32.11.9-0.8-1.31.1-1.11.80.3-1.10.6-0.4-0.8
Std. dev. reaction times0.41.44.11.2-0.6-1.9-0.9-0.70.8-0.8-2.01.4-0.80.41.7-0.9
Reaction time trials completed0.51.75.3-2.32.11.4-0.9-1.21.0-1.01.50.2-1.21.2-0.1-1.1
Reaction time trials AUC0.51.85.3-2.32.11.4-1.0-1.31.1-1.11.40.3-1.31.2-0.0-1.1
Run reversals in cocaine runway, females0.10.10.6-0.50.10.40.00.1-0.20.20.7-0.1-0.00.4-0.30.3
Run reversals in cocaine runway, males0.30.31.70.7-0.0-1.30.10.3-0.30.30.3-0.20.20.50.4-1.1
Latency to leave start box in cocaine runway1.21.72.7-0.71.0-0.4-1.5-1.41.6-1.60.21.5-1.61.31.4-1.4
Latency to leave start box in cocaine runway, F0.81.01.9-0.50.9-0.5-1.1-0.91.1-1.1-0.21.1-1.11.11.1-1.4
Latency to leave start box in cocaine runway, M1.41.32.4-0.70.7-0.3-1.3-1.51.6-1.60.41.2-1.41.21.0-1.0
Std. dev. time between licks in bursts0.81.55.42.1-2.3-1.50.31.0-0.60.6-1.40.70.4-0.81.11.2
Total sessions with >9 infusions0.10.10.30.5-0.6-0.30.3-0.1-0.10.1-0.2-0.50.4-0.4-0.40.5
Short access day 1 total inactive lever presses1.12.24.52.1-1.5-1.31.81.7-1.51.5-1.5-1.51.8-1.2-0.70.5
Short access day 10 total inactive lever presses0.10.71.50.3-0.10.51.21.1-0.80.80.2-1.21.1-1.0-1.00.5
Short access day 1 total infusions0.10.30.90.5-0.4-0.10.80.2-0.30.30.0-0.90.7-0.4-0.60.4
Short access day 10 total infusions0.30.41.91.1-0.5-1.40.10.1-0.10.1-1.3-0.10.30.10.3-0.5
Short access total infusions0.30.41.00.8-0.4-0.40.80.5-0.70.7-0.4-1.00.9-0.5-0.70.2
Short access day 1 locomotion0.81.43.31.1-0.7-1.8-0.9-1.21.3-1.3-1.61.2-0.70.81.3-0.6
Short access day 10 total locomotion0.10.30.90.8-1.0-0.9-0.3-0.40.2-0.2-0.80.5-0.00.10.50.3
Short access total locomotion0.40.62.01.3-1.2-1.4-0.2-0.50.5-0.5-1.20.50.0-0.00.60.2
One hour access (0.3 mA shock)0.70.81.70.9-0.6-0.41.21.1-1.01.0-0.3-1.31.2-0.8-0.90.3
Compulsive drug intake1.21.73.41.8-1.8-0.81.31.6-1.31.3-0.8-0.81.3-1.5-0.71.3
One hour access (shock baseline)0.00.10.5-0.40.70.00.0-0.20.1-0.10.1-0.40.00.4-0.1-0.7
Social response proportion1.41.75.6-2.41.71.9-0.8-1.10.8-0.82.20.2-1.30.8-0.2-0.4
Social responses0.40.52.4-1.10.31.3-0.0-0.20.1-0.11.50.0-0.6-0.1-0.30.7
Social time0.30.51.31.1-1.1-1.0-0.10.5-0.30.3-1.00.6-0.2-0.20.70.6
Soleus weight4.011.717.3-3.03.9-0.1-3.9-4.24.1-4.1-0.23.1-3.94.02.5-3.9
Bone: stiffness0.40.71.71.3-1.3-0.60.90.8-0.70.7-0.4-0.60.4-0.9-0.30.9
Tibialis anterior weight3.612.319.1-1.62.8-1.8-4.1-4.44.3-4.3-1.93.5-3.84.03.1-4.1
Time to tail flick, vehicle, before self-admin3.44.27.30.9-0.80.72.52.5-2.72.70.0-2.52.6-2.1-2.31.5
Time to tail flick, vehicle, after self-admin0.71.55.4-2.02.32.00.40.1-0.40.41.2-1.2-0.0-0.0-1.2-0.8
Time to tail flick, test, before self-admin1.01.22.51.3-1.6-0.41.01.5-1.21.2-0.0-0.71.2-1.0-0.71.3
Time to tail flick, test, after self-admin1.31.43.4-0.2-0.61.51.21.0-1.21.20.9-1.10.9-1.5-1.41.8
Delta time to tail flick, vehicle, before/after SA0.90.93.2-1.61.81.3-0.2-0.60.5-0.51.4-0.3-0.70.5-0.3-0.9
Delta time to tail flick, test, before/after SA0.70.84.3-1.60.82.10.2-0.30.1-0.11.2-0.4-0.3-0.3-0.80.9
Tibia length4.813.430.45.5-5.5-2.53.53.7-3.23.2-2.9-2.34.1-4.1-1.43.3
Ambulatory time before self-admin0.41.12.00.00.2-1.1-1.2-1.41.1-1.1-0.51.3-1.11.21.3-1.1
Ambulatory time after self-admin2.13.36.5-1.31.6-0.6-2.1-2.62.2-2.20.41.7-2.02.11.4-2.2
Bone: tissue strength0.20.20.90.8-0.9-0.70.10.1-0.20.2-0.30.30.1-0.10.50.5
Total heroin consumption0.50.62.1-0.41.0-0.6-0.6-0.50.4-0.4-1.20.3-0.41.00.5-1.5
Bone: trabecular number0.20.30.70.6-0.8-0.10.60.4-0.60.6-0.1-0.60.3-0.5-0.20.8
Bone: trabecular spacing0.60.91.7-0.70.8-0.1-1.3-1.21.1-1.1-0.11.1-1.10.90.9-0.8
Bone: trabecular thickness0.71.02.51.1-0.9-0.31.31.1-1.11.1-0.3-1.31.6-0.8-0.70.5
Bone: trabecular tissue density0.61.01.7-0.60.8-0.4-1.2-1.21.3-1.2-0.21.1-1.31.10.7-1.2
Water consumed over 24 hours0.00.10.40.10.0-0.4-0.1-0.30.2-0.20.60.0-0.30.40.3-0.3
Number of responses in last shaping day0.20.30.8-0.70.80.1-0.6-0.40.4-0.40.10.2-0.40.90.3-0.8