Hub : Genes

Itm2b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver mRNA stability Itm2b 0.1 0.05 4.5e-11 0.08 0.08 0.08 0.08 1.8e-09 1.4e-09 2.4e-09 6.2e-09
2 PL mRNA stability Itm2b 0.05 0.03 5.1e-05 0.04 0.03 0.03 0.03 3.7e-05 5.8e-04 1.4e-04 1.2e-04
3 Liver gene expression Itm2b 0.11 0.06 3.0e-10 0.08 0.07 0.06 0.07 6.4e-09 1.1e-08 2.9e-07 2.1e-08
4 IC gene expression Itm2b 0.46 0.14 3.3e-08 0.17 0.15 0.14 0.15 1.3e-07 7.9e-07 2.0e-06 9.2e-07
5 Brain mRNA stability Itm2b 0.21 0.11 4.0e-14 0.12 0.17 0.17 0.18 2.7e-11 2.8e-15 1.3e-15 2.9e-16
6 Brain gene expression Itm2b 0.58 0.14 0.0e+00 0.34 0.34 0.33 0.34 2.8e-33 1.7e-32 7.6e-32 1.1e-32
7 IL gene expression Itm2b 0.37 0.15 1.2e-06 0.22 0.21 0.22 0.22 6.8e-06 7.3e-06 5.6e-06 4.5e-06
8 OFC gene expression Itm2b 0.19 0.11 2.4e-03 0.13 0.06 0.05 0.08 5.2e-04 1.3e-02 2.7e-02 5.1e-03
9 NAcc gene expression Itm2b 0.37 0.12 0.0e+00 0.18 0.19 0.19 0.18 1.3e-26 1.1e-27 2.4e-27 1.1e-26
10 BLA gene expression Itm2b 0.35 0.14 1.5e-08 0.16 0.14 0.18 0.15 1.1e-08 4.4e-08 1.1e-09 3.5e-08
11 Adipose gene expression Itm2b 0.1 0.05 1.2e-11 0.09 0.1 0.09 0.1 2.3e-10 3.2e-11 1.3e-10 6.2e-11
12 PL gene expression Itm2b 0.22 0.08 0.0e+00 0.21 0.24 0.24 0.24 2.0e-22 1.1e-25 9.7e-26 7.3e-26
13 pVTA mRNA stability Itm2b 0.08 0.05 1.0e-05 0.07 0.07 0.07 0.08 1.4e-06 3.1e-06 3.1e-06 6.9e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.00.10.20.40.40.3-0.30.0-0.2-0.20.2-0.3-0.20.20.20.2
Area under the delay curve0.30.31.30.80.71.10.0-0.30.10.10.90.30.00.30.6-0.1
BMI with tail0.10.21.1-0.5-0.1-0.7-0.0-0.20.10.1-1.0-0.20.0-0.0-0.50.4
BMI without tail0.30.83.4-1.1-0.6-1.6-0.40.2-0.4-0.4-1.8-0.8-0.2-0.2-1.30.6
Body weight0.10.51.21.10.70.4-0.80.7-0.6-0.60.2-0.7-0.8-1.0-0.80.4
Weight adjusted by age1.42.15.0-0.2-0.30.91.7-1.41.51.51.22.21.81.32.0-1.1
Bone surface0.10.30.90.80.70.9-0.1-0.40.20.20.70.00.30.30.70.1
Bone volume0.10.20.60.60.40.8-0.1-0.2-0.0-0.00.7-0.10.10.50.5-0.1
Breakpoint value in progressive ratio session0.30.42.0-0.7-1.4-0.00.2-0.20.10.1-0.2-0.20.20.70.0-1.4
Number of licking bursts0.81.32.50.10.1-0.9-1.41.1-1.3-1.3-0.8-1.6-1.2-1.1-1.50.8
Context. condit. distance diff. score3.34.09.6-1.8-0.9-3.1-1.41.3-1.7-1.7-2.8-2.4-1.2-1.1-3.11.5
Locomotion velocity, session 11.51.72.7-0.3-0.71.01.6-1.31.21.21.31.61.41.51.6-1.5
Locomotion distance, session 10.40.62.11.00.61.40.2-0.10.30.31.30.60.30.41.0-0.5
Locomotion velocity, session 20.40.51.80.70.61.10.3-0.20.10.11.30.70.30.41.2-0.4
Locomotion distance, session 21.21.66.21.70.92.50.3-0.10.50.52.20.90.10.71.8-1.1
Locomotion velocity, session 30.30.41.0-0.8-0.5-1.0-0.20.3-0.6-0.6-1.0-0.5-0.4-0.0-0.50.3
Locomotion distance, session 31.01.12.0-0.7-0.1-1.4-1.01.0-1.2-1.2-1.3-1.3-0.8-0.6-1.40.8
Stereotopy head waving bouts, day 30.60.71.6-0.6-0.80.31.0-0.50.80.80.11.20.60.91.2-1.0
Stereotopy head waving duration, day 30.91.12.1-0.3-0.80.91.2-0.91.11.10.81.40.61.21.4-1.4
Locomotion velocity, session 77.98.614.6-1.5-0.3-3.8-3.02.8-3.2-3.2-3.7-3.6-2.6-2.2-3.62.7
Locomotion distance, session 74.65.813.5-1.5-0.5-3.3-2.22.0-2.4-2.4-3.7-3.0-1.7-1.6-2.92.0
Stereotopy head waving bouts, day 70.40.52.10.80.51.10.20.2-0.0-0.01.40.7-0.40.20.9-0.4
Stereotopy head waving duration, day 70.50.62.00.50.11.00.6-0.40.50.51.41.10.10.51.1-0.7
Locomotion velocity, session 80.50.61.1-0.3-0.2-0.8-0.91.0-1.0-1.0-0.6-1.1-1.0-0.4-1.00.3
Locomotion distance, session 81.01.42.70.40.6-0.5-1.51.5-1.6-1.6-0.6-1.6-1.4-0.8-1.40.9
Degree of sensitization distance1.61.74.9-1.0-0.5-2.0-1.20.9-1.1-1.1-2.2-1.5-0.8-0.7-1.41.1
Degree of sensitization stereotypy0.30.31.40.80.50.8-0.20.2-0.3-0.31.20.1-0.5-0.20.3-0.1
Conditioned locomotion0.30.41.4-1.0-0.7-1.20.3-0.40.20.1-1.1-0.20.6-0.0-0.60.1
Cocaine response after cond. corrected1.31.64.5-2.1-2.0-1.41.1-1.20.80.8-1.40.51.31.00.1-0.9
Cocaine response after cond. not corrected0.40.51.8-1.3-1.1-1.00.5-0.40.10.1-0.90.10.60.6-0.1-0.4
Cocaine response before conditioning2.22.75.32.32.31.2-1.62.0-1.7-1.71.4-1.0-1.8-1.4-0.51.4
Saline control response0.60.82.11.40.90.9-1.00.9-0.8-0.80.6-0.9-0.9-1.0-0.60.2
Bone: connectivity density0.30.41.10.80.9-0.0-0.70.3-0.4-0.4-0.1-0.7-0.5-0.9-0.51.1
Bone: cortical apparent density0.60.93.3-1.4-1.2-1.70.0-0.40.10.1-1.8-0.40.6-0.3-0.90.1
Bone: cortical area0.10.10.30.40.40.5-0.2-0.20.20.20.30.10.20.20.60.1
Bone: cortical porosity1.01.13.71.91.71.5-0.40.8-0.5-0.51.50.0-0.9-0.60.20.6
Bone: cortical porosity0.80.93.31.81.61.6-0.20.5-0.3-0.31.50.2-0.6-0.40.30.3
Bone: cortical thickness0.20.30.90.50.6-0.0-0.90.6-0.6-0.6-0.1-0.7-0.7-0.7-0.30.6
Bone: cortical thickness0.50.61.7-0.9-0.7-1.3-0.70.3-0.5-0.5-1.3-1.0-0.2-0.3-0.60.3
Bone: cortical tissue density0.70.93.5-1.5-1.2-1.8-0.0-0.40.00.0-1.9-0.50.5-0.4-1.00.2
Condit. Reinf. active minus inactive responses0.60.62.41.51.21.3-0.10.5-0.2-0.21.10.5-0.2-0.70.70.2
Condit. Reinf. active-inactive response ratio0.70.71.7-0.5-0.50.11.2-1.01.01.0-0.21.21.30.60.9-0.6
Condit. Reinf. active responses1.62.05.82.42.11.5-1.21.5-1.2-1.21.4-0.4-1.2-1.50.21.0
Condit. Reinf. inactive responses3.44.28.93.02.61.6-2.12.3-2.0-2.01.8-1.4-2.4-2.1-0.71.5
Incentive salience index mean2.32.88.93.02.71.9-1.11.6-1.2-1.21.7-0.1-1.3-1.80.31.3
Condit. Reinf. lever presses3.95.413.63.73.61.8-2.12.5-2.2-2.21.7-1.0-2.1-2.7-0.52.1
Condit. Reinf. active minus inactive responses0.20.30.90.40.7-0.3-0.80.5-0.3-0.3-0.2-0.4-0.4-0.8-0.20.9
Condit. Reinf. active-inactive response ratio0.10.10.3-0.10.3-0.3-0.30.3-0.2-0.2-0.1-0.1-0.2-0.10.00.5
Condit. Reinf. active responses0.50.61.60.60.9-0.4-1.10.8-0.6-0.6-0.4-0.8-0.8-1.1-0.51.3
Condit. Reinf. inactive responses1.01.32.31.01.0-0.2-1.51.2-1.1-1.1-0.4-1.4-1.3-1.4-1.01.2
Condit. Reinf. lever presses0.81.14.51.92.11.3-0.60.7-0.3-0.31.10.0-0.7-0.80.41.1
Condit. Reinf. lever reinforcers received0.60.91.90.91.1-0.2-1.30.9-0.8-0.8-0.3-0.9-1.1-1.2-0.61.4
Conditioned reinforcement - actives0.30.51.9-1.1-0.7-1.30.0-0.50.20.2-1.4-0.30.40.1-0.40.3
Conditioned reinforcement - inactives1.52.24.62.02.20.8-1.51.5-1.6-1.60.5-1.0-1.6-1.6-0.81.7
Conditioned locomotion0.50.61.6-0.3-0.20.40.8-1.31.21.20.30.60.71.00.7-0.5
Patch foraging indifference point 0 sec3.05.610.03.13.21.4-2.62.7-2.4-2.41.6-1.7-2.6-2.6-1.12.2
Patch foraging indifference point AUC0.91.33.4-1.8-1.5-1.10.9-1.30.90.9-1.00.61.11.50.6-0.8
Delay disc. indifference point, 0s delay1.11.22.81.10.91.70.9-0.80.90.91.71.50.90.41.5-0.3
Delay disc. indifference point, 16s delay0.10.20.70.50.20.80.0-0.40.20.20.70.0-0.10.30.3-0.4
Delay disc. indifference point, 2s delay2.32.54.8-0.1-0.11.21.9-1.92.02.01.12.21.71.72.0-1.0
Delay disc. indifference point, 24s delay0.10.10.2-0.4-0.3-0.20.1-0.40.20.2-0.1-0.10.10.40.0-0.2
Delay disc. indifference point, 4s delay0.80.81.3-0.2-0.20.61.0-1.11.11.10.61.11.11.01.1-0.7
Delay disc. indifference point, 8s delay0.50.50.90.90.80.4-0.90.6-0.9-0.9-0.0-0.8-0.8-0.6-0.50.6
Indifference point function ln k1.01.73.92.01.90.9-1.11.4-1.1-1.10.7-0.8-1.3-1.8-0.91.3
Indifference point function log k1.01.73.92.01.90.9-1.11.4-1.1-1.10.7-0.8-1.3-1.8-0.91.3
Patch foraging total patch changes 0 sec2.95.49.53.13.01.5-2.62.8-2.4-2.41.6-1.7-2.6-2.5-1.12.0
Patch foraging total patch changes 12 sec0.81.12.31.51.31.0-1.21.1-1.1-1.11.1-0.7-1.2-0.70.10.5
Patch foraging total patch changes 18 sec0.71.12.10.30.3-0.4-1.31.2-1.4-1.4-0.5-1.4-1.4-0.9-1.10.7
Patch foraging total patch changes 24 sec0.81.32.91.71.40.9-1.51.1-1.1-1.11.0-1.0-1.4-1.0-0.30.7
Patch foraging total patch changes 6 sec2.13.36.10.81.0-0.8-2.52.1-2.1-2.1-0.5-2.2-2.2-2.0-1.91.7
Patch foraging time to switch 0 sec0.00.10.20.20.10.20.3-0.00.20.20.20.30.40.00.3-0.1
Patch foraging water rate 0 sec0.51.02.61.00.70.3-1.31.0-1.0-1.00.5-1.3-1.6-1.1-1.00.6
Patch foraging water rate 12 sec0.00.00.20.10.1-0.10.0-0.40.30.3-0.20.10.1-0.4-0.10.1
Patch foraging water rate 18 sec0.20.30.9-0.7-0.5-1.0-0.3-0.2-0.0-0.0-0.6-0.5-0.0-0.3-0.90.1
Patch foraging water rate 24 sec1.01.43.0-0.5-0.6-1.4-1.30.9-1.1-1.1-1.4-1.7-1.3-1.1-1.60.7
Patch foraging water rate 6 sec0.20.30.70.1-0.30.70.6-0.70.70.70.70.3-0.00.50.3-0.8
Seeking ratio, delayed vs. immediate footshock0.20.20.90.50.70.30.5-0.10.30.30.10.90.4-0.40.60.5
Distance traveled before self-admin2.33.04.9-0.1-0.31.52.1-2.22.02.00.52.22.01.82.0-1.6
Distance traveled after self-admin2.32.85.6-1.8-1.7-0.21.9-2.41.91.9-0.71.41.92.01.0-1.6
Extensor digitorum longus weight5.521.532.3-2.8-4.21.85.5-5.75.55.51.94.84.95.44.1-5.5
Bone: elastic displacement0.30.41.50.90.41.20.10.00.10.11.00.5-0.30.10.8-0.5
Bone: elastic work0.91.24.71.60.92.20.2-0.00.30.32.00.8-0.30.51.3-0.8
Bone: endosteal estimation0.20.51.00.30.40.90.8-0.60.60.60.50.80.80.91.0-0.3
Bone: endosteal perimeter0.51.02.00.20.31.01.1-1.11.01.00.81.31.31.11.4-0.4
Epididymis fat weight0.31.12.41.31.60.1-0.91.1-1.0-1.00.0-0.7-1.2-1.4-0.71.4
Delta time in closed arm before/after self-admin0.30.31.50.71.20.2-0.30.3-0.2-0.20.2-0.0-0.4-0.4-0.11.1
Delta time in open arm before/after self-admin0.00.00.1-0.2-0.20.10.10.3-0.2-0.2-0.30.10.10.40.3-0.3
Diff in mean of infusions in LGA sessions0.20.20.8-0.2-0.80.0-0.30.4-0.5-0.50.6-0.4-0.20.1-0.1-0.9
Delay discount exponential model param0.30.31.3-0.7-0.6-1.1-0.20.5-0.3-0.3-0.8-0.4-0.2-0.5-0.70.2
Extinction: sum of active levers before priming0.50.61.20.60.60.2-0.81.0-1.1-1.10.4-0.8-1.0-0.4-0.40.5
Active lever presses in extinction session 61.01.02.1-0.00.0-0.8-1.31.1-1.1-1.1-0.9-1.5-1.2-0.8-1.20.6
Bone: final force0.81.22.21.51.50.4-1.31.2-1.1-1.10.1-1.0-1.1-1.3-0.51.2
Bone: final moment0.61.02.91.71.60.7-1.00.9-0.8-0.80.3-0.7-0.9-1.1-0.11.0
Food consumed during 24 hour testing period0.20.21.00.81.00.8-0.10.20.0-0.00.10.30.20.10.50.3
Glucose0.50.83.2-1.5-1.1-1.4-0.4-0.3-0.1-0.1-1.8-0.80.20.6-0.7-0.1
Heart weight0.00.10.30.10.5-0.00.00.1-0.2-0.20.00.20.40.10.20.5
Delay discount hyperbolic model param0.40.41.2-0.6-0.5-1.1-0.40.7-0.5-0.5-0.8-0.6-0.4-0.6-0.90.3
Intermittent access intake day 1-15 change1.83.85.91.01.0-0.8-2.22.4-2.4-2.4-0.7-2.3-2.4-2.2-2.21.6
Intermittent access intake escalation1.93.96.11.31.4-0.6-2.22.4-2.4-2.4-0.4-2.2-2.5-2.4-2.11.8
Intermittent access intake escalation 21.01.22.00.10.5-1.1-1.11.0-1.1-1.1-1.2-1.2-1.1-1.3-1.41.3
Intermitt. access day 1 inactive lever presses0.41.32.30.10.2-1.0-1.41.2-1.3-1.3-1.0-1.4-1.1-1.5-1.31.0
Intermitt. access day 15 inactive lever presses0.71.52.71.21.10.1-1.51.6-1.6-1.6-0.0-1.2-1.3-1.4-1.01.0
Intermitt. access escalation Index0.00.10.20.0-0.10.30.3-0.10.20.20.40.20.10.20.1-0.5
Intermittent access day 1 total infusions0.60.91.70.90.60.3-1.21.2-1.2-1.20.3-1.3-1.3-0.8-0.80.5
Intermittent access day 15 total infusions2.53.75.61.61.6-0.1-2.22.4-2.3-2.3-0.0-2.1-2.4-2.2-1.81.8
Intermittent access terminal intake (last 3 days)1.72.23.70.60.8-0.7-1.71.6-1.8-1.8-0.7-1.9-1.8-1.6-1.71.4
Intermittent access total infusions2.53.05.01.01.1-0.4-2.12.0-2.1-2.1-0.4-2.2-2.2-1.8-1.81.5
Intermittent access day 1 locomotion1.62.03.21.61.50.4-1.71.5-1.5-1.50.2-1.5-1.8-1.6-1.11.4
Intermittent access day 15 total locomotion0.61.12.00.00.1-0.8-1.21.3-1.4-1.4-0.9-1.4-1.2-0.9-1.20.7
Intermittent access total locomotion1.11.32.00.91.0-0.1-1.31.2-1.4-1.3-0.3-1.3-1.4-1.3-1.01.1
Intermittent access standard deviation0.20.31.30.0-0.70.0-0.70.3-0.7-0.60.1-1.1-0.7-0.1-0.6-0.7
Left kidney weight0.73.210.52.93.21.6-1.21.4-1.4-1.41.4-0.5-1.7-1.8-0.32.0
Right kidney weight0.73.312.33.53.42.7-0.50.4-0.4-0.42.50.3-0.8-1.30.51.3
Cocaine induced anxiety1.42.05.61.71.32.41.0-0.91.21.22.31.60.70.41.6-0.5
Post-drug Anxiety0.80.92.91.71.61.50.2-0.10.10.11.30.80.0-0.60.80.5
Baseline Anxiety1.61.93.2-0.30.2-1.5-1.41.5-1.8-1.8-1.5-1.5-1.2-1.2-1.51.5
Tail length0.21.01.61.31.00.4-1.11.2-1.1-1.10.3-0.8-1.0-1.2-0.90.8
Length with tail0.31.14.12.01.21.5-0.70.9-0.7-0.71.5-0.3-0.8-1.2-0.10.0
Length without tail0.30.92.60.90.01.50.6-0.80.70.71.60.80.70.21.1-1.2
Times rat made contact with spout3.23.76.60.60.9-1.1-2.42.2-2.2-2.2-1.6-2.6-2.2-1.8-2.11.8
Lifetime Intake1.72.14.00.90.9-0.3-1.81.6-1.8-1.8-0.3-2.0-1.8-1.5-1.61.3
Liver weight, left1.42.36.61.80.92.61.0-0.91.01.02.41.80.90.52.2-1.0
Liver weight, right0.30.52.0-0.5-1.10.30.5-0.70.60.6-0.10.10.41.00.2-1.4
Locomotor activity4.97.717.12.11.14.02.5-2.32.82.84.13.22.01.83.4-2.2
Locomotor testing distance2.54.513.82.71.73.71.4-1.01.61.63.72.20.90.62.5-1.1
Locomotor testing rearing2.34.615.13.22.23.91.1-0.71.21.23.91.90.40.22.3-0.8
Locomotion in novel chamber0.40.51.31.10.90.8-0.50.6-0.6-0.60.8-0.6-0.9-0.3-0.30.3
Locomotion in novel chamber post-restriction0.20.30.9-0.7-0.9-0.30.3-0.20.30.3-0.30.10.41.00.4-0.8
Fecal boli incidents, locomotor time 10.30.52.10.90.01.4-0.20.00.20.21.5-0.2-0.20.30.3-1.0
Change in fecal boli incidents, locomotor task0.90.91.9-0.8-0.5-0.41.4-0.91.01.0-1.11.41.30.70.9-0.2
Time >=10cm from walls, locomotor time 10.50.61.81.41.20.5-0.40.6-0.2-0.20.9-0.2-0.8-0.9-0.30.8
Bouts of movement, locomotor time 10.50.61.4-1.0-1.2-0.60.8-0.91.01.00.50.30.60.50.0-0.8
Total resting periods, locomotor time 10.80.92.0-1.3-1.4-0.70.9-1.11.21.20.10.40.80.70.2-1.0
Rest time, locomotor task time 11.01.22.3-1.0-1.5-0.21.2-1.21.31.30.00.81.01.40.8-1.5
Distance moved, locomotor task time 11.11.63.10.61.1-0.7-1.41.3-1.7-1.7-0.4-1.1-1.3-1.7-1.11.8
Vertical activity count, locomotor time 10.10.30.60.40.10.70.6-0.80.50.50.50.60.50.20.6-0.5
Time >=10cm from walls, locomotor time 21.32.03.7-0.4-0.80.61.7-1.71.91.90.11.61.81.31.4-1.4
Bouts of movement, locomotor time 20.50.93.1-1.4-1.8-0.60.7-0.70.80.80.10.20.61.10.3-1.4
Total resting periods, locomotor time 20.40.72.8-1.2-1.7-0.50.5-0.50.70.70.2-0.00.40.90.1-1.4
Rest time, locomotor task time 20.30.41.8-0.8-1.3-0.6-0.30.2-0.2-0.2-0.4-0.6-0.20.7-0.3-1.0
Distance moved, locomotor task time 20.60.71.91.21.40.3-0.60.6-0.7-0.70.4-0.4-0.8-1.3-0.41.2
Vertical activity count, locomotor time 20.81.12.00.0-0.31.01.4-1.31.21.20.81.21.11.01.1-1.1
Light reinforcement 11.43.54.90.51.0-1.2-2.22.2-2.1-2.1-1.1-2.2-2.2-1.9-2.22.0
Light reinforcement 21.62.56.8-1.5-0.6-2.6-1.21.0-1.1-1.1-2.5-1.8-0.9-1.0-2.21.3
Bone: marrow area0.20.40.90.40.40.90.7-0.60.60.60.50.80.80.81.0-0.2
Bone: maximum diameter0.30.61.3-0.9-0.7-0.20.7-1.00.90.9-0.20.71.11.10.9-0.5
Bone: maximum force0.30.52.01.41.21.1-0.60.4-0.4-0.40.6-0.3-0.4-0.40.40.3
Bone: maximum moment0.40.62.81.71.31.4-0.30.2-0.1-0.10.90.1-0.2-0.20.80.2
Mean time between licks in bursts0.10.21.40.00.4-0.3-0.30.5-0.5-0.5-1.2-0.3-0.1-0.2-0.10.6
Mean num. licks in bursts0.00.00.10.10.30.0-0.30.10.10.1-0.3-0.4-0.3-0.0-0.10.3
Cd content in liver1.11.23.60.4-0.71.51.0-1.01.21.20.71.00.61.01.2-1.9
Co content in liver3.03.57.8-2.5-2.8-0.71.7-1.91.81.8-1.31.11.92.30.8-2.2
Cu content in liver0.30.31.6-0.8-0.7-0.30.3-0.50.50.5-1.30.20.60.40.2-0.4
Fe content in liver0.30.31.00.30.7-0.4-0.30.6-0.6-0.6-0.6-0.1-0.2-0.8-0.31.0
K content in liver1.81.83.70.31.1-1.1-1.41.3-1.5-1.5-0.7-1.4-1.2-1.5-1.61.9
Mg content in liver0.60.61.2-0.20.4-0.9-0.90.7-0.9-0.9-0.9-0.8-0.4-0.6-0.81.1
Mn content in liver0.20.20.6-0.8-0.6-0.50.1-0.30.20.2-0.7-0.10.20.5-0.4-0.2
Na content in liver1.82.07.32.01.62.40.7-0.40.50.52.71.4-0.20.21.6-0.3
Rb content in liver0.10.10.4-0.2-0.2-0.5-0.20.1-0.2-0.2-0.4-0.3-0.1-0.5-0.60.2
Se content in liver2.12.55.91.00.52.11.8-1.11.51.51.52.41.01.22.4-1.1
Sr content in liver1.61.42.4-0.5-0.70.61.3-1.41.41.4-0.41.31.51.51.4-1.2
Zn content in liver0.20.31.00.40.11.00.2-0.40.30.30.20.50.40.50.9-0.6
Bone: minimum diameter0.30.51.50.80.71.20.1-0.50.70.70.70.50.50.51.2-0.2
Time in familiar zone, hab. session 10.90.91.60.30.6-0.6-1.11.0-1.1-1.1-0.6-1.1-1.1-0.9-1.31.0
Time in novel zone, hab. session 13.23.26.0-2.1-2.4-0.51.9-2.01.91.9-0.31.42.11.91.4-2.0
Total zone transitions, hab. session 10.30.51.60.3-0.11.00.4-0.30.50.50.80.80.50.71.3-0.8
Total locomotion distance, hab. session 10.60.92.71.20.81.60.3-0.00.50.51.60.90.30.31.4-0.3
Locomotion velocity, hab. session 11.21.65.72.11.62.40.20.30.40.42.40.8-0.30.01.4-0.2
Time in familiar zone, hab. session 20.90.92.4-1.4-1.5-0.70.9-1.21.01.0-0.50.30.91.0-0.2-1.0
Time in novel zone, hab. session 20.10.10.40.40.40.4-0.20.4-0.3-0.30.30.1-0.1-0.00.60.0
Total zone transitions, hab. session 21.72.24.51.00.22.11.3-1.21.61.62.01.61.41.01.7-1.5
Total locomotion distance, hab. session 21.01.33.11.00.31.80.9-0.71.11.11.71.11.00.61.4-1.0
Locomotion velocity, hab. session 21.51.94.71.10.42.21.2-1.01.31.32.11.41.20.91.7-1.3
Novel to familiar place preference ratio1.11.22.81.20.90.3-1.71.5-1.3-1.30.0-1.1-1.4-1.2-0.40.7
Novelty place preference1.31.42.91.31.00.4-1.71.6-1.4-1.40.1-1.1-1.6-1.3-0.50.8
Time in novel zone, NPP test1.01.02.21.10.80.3-1.51.4-1.2-1.20.1-0.9-1.4-1.0-0.30.6
Total zone transitions, NPP test0.30.51.71.20.81.3-0.2-0.10.20.21.30.10.3-0.20.5-0.2
Total locomotion distance, NPP test0.60.82.91.71.41.2-0.70.6-0.4-0.41.3-0.5-0.4-0.80.10.5
Locomotion velocity, NPP test0.71.03.31.81.51.2-1.00.8-0.6-0.61.2-0.7-0.6-1.1-0.20.7
Intraocular pressure0.71.12.30.50.3-0.4-1.51.4-1.3-1.3-0.6-1.3-1.3-1.1-0.70.7
Delta distance traveled before/after self-admin1.21.34.6-2.1-2.0-1.90.1-0.50.30.3-1.6-0.50.50.6-0.8-0.5
Delta ambulatory time before/after self-admin0.60.82.5-1.5-1.6-1.30.0-0.40.30.3-1.3-0.50.30.4-0.7-0.6
Parametrial fat weight1.12.54.40.91.1-0.7-2.11.8-1.6-1.6-1.0-1.9-1.9-2.0-1.61.7
Pavlov. Cond. lever latency2.02.54.7-2.2-2.1-0.71.7-1.71.61.6-0.51.21.72.11.0-1.6
Pavlov. Cond. magazine entry latency0.60.81.50.70.9-0.3-1.20.9-1.0-1.0-0.6-0.9-0.6-1.2-0.91.1
Pavlov. Cond. change in total contacts1.11.13.01.71.40.9-1.21.1-0.9-0.90.6-0.7-1.1-1.3-0.20.7
Pavlov. Cond. index score2.02.64.42.12.00.5-1.91.7-1.7-1.70.3-1.4-1.6-2.1-1.21.6
Pavlov. Cond. latency score2.63.35.62.32.30.5-2.12.0-1.9-1.90.3-1.5-1.9-2.4-1.31.9
Pavlov. Cond. lever contacts2.93.55.92.32.30.5-2.12.0-1.9-1.90.4-1.6-2.0-2.4-1.51.9
Pavlov. Cond. magazine entry number0.30.40.8-0.7-0.7-0.10.9-0.60.70.70.20.70.40.80.5-0.6
Pavlov. Cond. intertrial magazine entries0.81.03.51.91.61.3-0.40.6-0.3-0.31.4-0.1-1.1-1.00.10.8
Pavlov. Cond. lever-magazine prob. diff.1.72.13.92.01.90.6-1.71.5-1.5-1.50.4-1.2-1.4-1.8-1.01.4
Pavlov. Cond. response bias0.60.71.51.11.10.2-1.00.8-0.9-0.9-0.1-0.8-0.6-1.2-0.80.9
Pavlov. Cond. lever latency1.11.44.4-1.8-1.7-2.1-0.40.4-0.8-0.8-1.9-1.1-0.2-0.2-1.3-0.1
Pavlov. Cond. magazine entry latency0.70.82.91.71.51.7-0.00.20.00.01.40.3-0.6-0.00.50.2
Pavlov. Cond. change in total contacts1.62.64.50.40.21.71.8-1.82.02.01.32.11.71.41.9-1.2
Pavlov. Cond. index score1.11.54.91.71.42.20.7-0.60.90.92.01.10.30.51.3-0.4
Pavlov. Cond. latency score1.21.65.11.81.62.30.7-0.50.80.82.01.20.30.41.3-0.2
Pavlov. Cond. lever contacts1.01.44.61.91.72.10.4-0.40.80.81.91.00.10.21.20.0
Pavlov. Cond. magazine entry number0.40.51.7-1.3-1.3-1.3-0.0-0.2-0.0-0.0-0.8-0.20.3-0.0-0.4-0.3
Pavlov. Cond. intertrial magazine entries3.04.57.20.71.4-1.4-2.72.2-2.4-2.4-1.2-2.6-2.2-2.4-2.22.5
Pavlov. Cond. lever-magazine prob. diff.1.01.34.11.51.32.00.8-0.60.90.91.81.10.30.51.2-0.3
Pavlov. Cond. response bias1.11.55.21.91.62.30.4-0.50.90.91.90.90.10.31.3-0.2
Time in closed arm before self-admin0.10.10.5-0.4-0.2-0.40.3-0.70.50.5-0.10.20.50.1-0.10.1
Time in closed arm after self-admin0.10.10.20.10.2-0.2-0.30.0-0.2-0.2-0.1-0.3-0.3-0.3-0.40.4
Time in open arm before self-admin0.20.20.6-0.3-0.60.20.5-0.20.40.40.50.30.20.40.4-0.7
Time in open arm after self-admin0.30.30.7-0.5-0.20.20.8-0.30.50.5-0.20.70.60.90.6-0.5
Bone: periosteal estimation0.20.41.00.20.30.70.6-0.70.60.60.40.70.80.81.0-0.2
Bone: periosteal perimeter0.20.31.0-0.1-0.00.40.5-0.70.60.60.10.60.80.81.0-0.3
Bone: post-yield work0.50.72.5-0.6-0.2-1.2-0.90.5-0.6-0.6-1.6-1.2-0.4-0.3-1.00.7
Progressive ratio test 1 active lever presses0.70.92.3-0.5-0.5-1.0-1.10.8-1.0-1.0-1.3-1.5-0.9-0.5-1.20.3
Progressive ratio test 1 breakpoint0.60.82.0-0.6-0.6-1.0-0.90.6-0.9-0.9-1.3-1.4-0.8-0.3-1.10.2
Progressive ratio test 1 inactive lever presses3.14.58.20.20.2-1.6-2.72.4-2.5-2.5-1.7-2.9-2.3-2.2-2.51.6
Progressive ratio test 2 active lever presses1.31.53.3-0.4-0.2-1.2-1.51.4-1.4-1.4-1.3-1.8-1.3-0.7-1.50.7
Progressive ratio test 2 breakpoint1.21.43.0-0.2-0.1-1.0-1.41.4-1.4-1.4-1.1-1.7-1.3-0.7-1.40.7
Progressive ratio test 2 inactive lever presses1.42.23.60.70.8-0.5-1.81.9-1.9-1.9-0.8-1.8-1.7-1.5-1.51.4
Incentive Sensitization - Responses0.40.61.10.00.3-0.6-1.01.0-0.9-0.9-0.5-1.0-0.9-0.5-0.90.7
Incentive Sensitization - Breakpoint0.60.81.40.20.5-0.5-1.21.2-1.0-1.0-0.4-1.2-1.1-0.6-1.00.8
Sum of active levers in priming session hrs 5-61.11.03.8-2.0-1.8-1.50.7-0.80.60.6-0.40.20.90.9-0.1-0.6
Progressive ratio0.40.61.8-1.3-1.4-1.0-0.0-0.10.20.2-1.2-0.8-0.10.4-1.0-0.6
Food seeking constrained by brief footshock4.04.916.4-3.7-4.0-2.21.3-1.91.41.4-2.10.22.02.0-0.4-2.6
Seeking ratio, punishment vs. effort0.60.92.2-0.8-0.8-0.31.0-1.21.01.00.21.31.50.91.0-0.7
Retroperitoneal fat weight0.62.44.70.81.1-0.9-1.61.6-1.5-1.5-0.9-1.5-1.7-2.2-1.82.0
Reaction time number correct1.01.85.4-2.3-2.2-1.41.0-1.31.11.1-1.50.31.31.3-0.0-1.1
Reaction time mean minus median0.71.65.51.70.92.30.7-0.40.70.72.41.20.50.21.6-0.9
Reaction time mean minus median AUC0.20.52.41.10.61.30.2-0.10.10.11.50.50.1-0.00.8-0.4
Reaction time num false alarms0.10.10.50.10.40.30.2-0.20.20.20.30.30.30.40.70.3
Reaction time num false alarms AUC0.10.10.30.10.50.10.0-0.10.00.00.10.20.30.30.50.6
Reaction time trials correct on left1.01.85.4-2.3-2.2-1.41.0-1.31.11.1-1.50.31.31.3-0.0-1.1
Reaction time trials on left0.91.75.3-2.3-2.1-1.40.9-1.21.01.0-1.50.21.21.2-0.1-1.1
Reaction time mean1.01.64.21.20.92.01.2-0.70.80.82.01.70.70.61.7-0.6
Reaction time mean AUC1.32.04.71.20.72.11.5-0.91.01.02.22.01.00.81.9-0.9
Median of all reaction times0.81.12.70.80.71.41.3-0.70.80.81.51.60.80.61.4-0.5
Reaction time omissions0.10.20.50.70.70.2-0.40.6-0.5-0.50.40.0-0.1-0.50.30.5
Reaction time false alarm rate0.40.51.81.01.40.5-0.70.7-0.7-0.70.6-0.3-0.6-0.50.11.1
Reaction time premature initiation rate0.30.51.3-1.0-0.9-1.10.3-0.70.60.6-1.00.20.5-0.1-0.4-0.2
Reaction time premature initiations1.01.85.2-2.3-2.1-1.90.8-1.31.11.1-1.80.31.10.6-0.4-0.8
Std. dev. reaction times0.81.44.11.20.61.90.9-0.70.80.82.01.40.80.41.7-0.9
Reaction time trials completed0.91.75.3-2.3-2.1-1.40.9-1.21.01.0-1.50.21.21.2-0.1-1.1
Reaction time trials AUC1.01.85.3-2.3-2.1-1.41.0-1.31.11.1-1.40.31.31.2-0.0-1.1
Run reversals in cocaine runway, females0.10.10.6-0.5-0.1-0.4-0.00.1-0.2-0.2-0.7-0.10.00.4-0.30.3
Run reversals in cocaine runway, males0.30.31.70.70.01.3-0.10.3-0.3-0.3-0.3-0.2-0.20.50.4-1.1
Latency to leave start box in cocaine runway1.51.72.6-0.7-1.00.41.5-1.41.61.6-0.21.51.61.31.4-1.4
Latency to leave start box in cocaine runway, F0.81.01.9-0.5-0.90.51.1-0.91.11.10.21.11.11.11.1-1.4
Latency to leave start box in cocaine runway, M1.41.32.4-0.7-0.70.31.3-1.51.61.6-0.41.21.41.21.0-1.0
Std. dev. time between licks in bursts1.11.55.42.12.31.5-0.31.0-0.6-0.61.40.7-0.4-0.81.11.2
Total sessions with >9 infusions0.10.10.30.50.60.3-0.3-0.1-0.1-0.10.2-0.5-0.4-0.4-0.40.5
Short access day 1 total inactive lever presses1.72.24.52.11.51.3-1.81.7-1.5-1.51.5-1.5-1.8-1.2-0.70.5
Short access day 10 total inactive lever presses0.30.71.50.30.1-0.5-1.21.1-0.8-0.8-0.2-1.2-1.1-1.0-1.00.5
Short access day 1 total infusions0.20.30.90.50.40.1-0.80.2-0.3-0.3-0.0-0.9-0.7-0.4-0.60.4
Short access day 10 total infusions0.30.41.91.10.51.4-0.10.1-0.1-0.11.3-0.1-0.30.10.3-0.5
Short access total infusions0.30.41.00.80.40.4-0.80.5-0.7-0.70.4-1.0-0.9-0.5-0.70.2
Short access day 1 locomotion1.11.43.31.10.71.80.9-1.21.31.31.61.20.70.81.3-0.6
Short access day 10 total locomotion0.20.30.90.81.00.90.3-0.40.20.20.80.50.00.10.50.3
Short access total locomotion0.50.62.01.31.21.40.2-0.50.50.51.20.5-0.0-0.00.60.2
One hour access (0.3 mA shock)0.70.81.70.90.60.4-1.21.1-1.0-1.00.3-1.3-1.2-0.8-0.90.3
Compulsive drug intake1.41.73.41.81.80.8-1.31.6-1.3-1.30.8-0.8-1.3-1.5-0.71.3
One hour access (shock baseline)0.10.10.5-0.4-0.7-0.0-0.0-0.20.10.1-0.1-0.4-0.00.4-0.1-0.7
Social response proportion1.51.75.6-2.4-1.7-1.90.8-1.10.80.8-2.20.21.30.8-0.2-0.4
Social responses0.40.52.4-1.1-0.3-1.30.0-0.20.10.1-1.50.00.6-0.1-0.30.7
Social time0.40.51.31.11.11.00.10.5-0.3-0.31.00.60.2-0.20.70.6
Soleus weight4.011.717.3-3.0-3.90.13.9-4.24.14.10.23.13.94.02.5-3.9
Bone: stiffness0.40.71.71.31.30.6-0.90.8-0.7-0.70.4-0.6-0.4-0.9-0.30.9
Tibialis anterior weight3.612.319.1-1.6-2.81.84.1-4.44.34.31.93.53.84.03.1-4.1
Time to tail flick, vehicle, before self-admin4.04.27.30.90.8-0.7-2.52.5-2.7-2.7-0.0-2.5-2.6-2.1-2.31.5
Time to tail flick, vehicle, after self-admin1.11.55.4-2.0-2.3-2.0-0.40.0-0.4-0.4-1.2-1.20.0-0.0-1.2-0.8
Time to tail flick, test, before self-admin1.11.22.51.31.60.4-1.01.5-1.2-1.20.0-0.7-1.2-1.0-0.71.3
Time to tail flick, test, after self-admin1.31.43.4-0.20.6-1.5-1.21.0-1.2-1.2-0.9-1.1-0.9-1.5-1.41.8
Delta time to tail flick, vehicle, before/after SA1.00.93.2-1.6-1.8-1.30.2-0.60.50.5-1.4-0.30.70.5-0.3-0.9
Delta time to tail flick, test, before/after SA0.80.84.3-1.6-0.8-2.1-0.2-0.30.10.1-1.2-0.40.3-0.3-0.80.9
Tibia length4.913.430.45.55.52.5-3.53.7-3.2-3.22.9-2.3-4.1-4.1-1.43.3
Ambulatory time before self-admin0.81.12.00.0-0.21.11.2-1.41.11.10.51.31.11.21.3-1.1
Ambulatory time after self-admin2.83.36.5-1.3-1.60.62.1-2.62.22.2-0.41.72.02.11.4-2.2
Bone: tissue strength0.20.20.90.80.90.7-0.10.1-0.2-0.20.30.3-0.1-0.10.50.5
Total heroin consumption0.50.62.1-0.4-1.00.60.6-0.50.40.41.20.30.41.00.5-1.5
Bone: trabecular number0.20.30.70.60.80.1-0.60.4-0.6-0.60.1-0.6-0.3-0.5-0.20.8
Bone: trabecular spacing0.70.91.7-0.7-0.80.11.3-1.21.11.10.11.11.10.90.9-0.8
Bone: trabecular thickness0.81.02.51.10.90.3-1.31.2-1.1-1.10.3-1.3-1.6-0.8-0.70.5
Bone: trabecular tissue density0.71.01.7-0.6-0.80.41.2-1.21.21.30.21.11.31.10.7-1.2
Water consumed over 24 hours0.10.10.40.1-0.00.40.1-0.30.20.2-0.60.00.30.40.3-0.3
Number of responses in last shaping day0.30.30.8-0.7-0.8-0.10.6-0.40.40.4-0.10.20.40.90.3-0.8