Hub : Genes

Itm2b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver mRNA stability Itm2b 0.1 0.05 1.5e-10 0.07 0.08 0.07 0.07 2.7e-08 4.8e-09 1.4e-08 1.9e-08
2 Brain mRNA stability Itm2b 0.21 0.11 2.5e-15 0.14 0.17 0.17 0.19 2.6e-13 4.6e-16 5.1e-16 3.0e-17
3 PL mRNA stability Itm2b 0.06 0.03 1.2e-05 0.05 0.05 0.04 0.05 3.0e-06 5.4e-06 1.0e-05 2.3e-06
4 pVTA mRNA stability Itm2b 0.14 0.07 1.3e-04 0.09 0.07 0.08 0.07 1.4e-04 5.1e-04 3.4e-04 3.6e-04
5 BLA gene expression Itm2b 0.45 0.15 2.3e-10 0.17 0.19 0.21 0.18 1.9e-09 1.7e-10 2.1e-11 6.3e-10
6 Adipose mRNA stability Itm2b 0.02 0.01 9.9e-03 0.01 0.01 0 0 3.6e-02 7.1e-02 8.5e-02 8.6e-02
7 Brain gene expression Itm2b 0.57 0.16 0.0e+00 0.33 0.31 0.32 0.31 4.4e-31 2.2e-29 7.4e-30 9.3e-30
8 IL gene expression Itm2b 0.39 0.17 9.8e-07 0.24 0.21 0.25 0.25 1.4e-06 7.7e-06 1.0e-06 8.1e-07
9 NAcc gene expression Itm2b 0.28 0.12 0.0e+00 0.18 0.17 0.18 0.18 1.0e-20 2.0e-19 2.3e-20 7.0e-21
10 pVTA gene expression Itm2b 0.13 0.09 2.1e-03 0.09 0.07 0.04 0.09 1.3e-04 3.8e-04 5.7e-03 7.6e-05
11 Liver gene expression Itm2b 0.1 0.06 2.6e-09 0.07 0.07 0.07 0.07 5.7e-08 3.7e-08 7.1e-08 8.5e-08
12 Adipose gene expression Itm2b 0.09 0.05 5.0e-11 0.09 0.09 0.09 0.09 1.7e-10 1.7e-10 9.6e-10 4.0e-10
13 PL gene expression Itm2b 0.24 0.09 0.0e+00 0.21 0.24 0.24 0.24 1.1e-22 5.9e-26 5.8e-26 2.8e-26

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.20.31.00.60.80.9-0.51.00.20.5-0.2-0.3-0.20.5-0.1-0.1
Area under the delay curve0.30.30.90.80.41.0-0.70.50.70.2-0.1-0.1-0.00.90.10.4
BMI with tail0.10.41.1-0.60.2-0.40.40.9-0.30.5-0.6-0.6-0.7-0.8-0.2-1.0
BMI without tail0.71.53.1-0.21.10.5-0.51.50.31.3-1.8-1.5-1.7-1.3-1.1-1.6
Body weight0.41.83.21.81.81.3-1.31.71.31.2-1.2-1.3-1.30.3-1.4-0.9
Weight adjusted by age2.02.25.4-0.0-1.6-0.6-0.2-2.3-0.3-1.81.82.01.91.21.21.9
Bone surface0.20.31.10.90.61.1-0.70.60.50.20.2-0.00.11.00.10.3
Bone volume0.20.30.80.60.60.9-0.40.8-0.00.20.1-0.10.10.90.30.3
Breakpoint value in progressive ratio session0.40.41.8-0.6-0.0-1.41.20.2-1.3-0.0-0.0-0.1-0.0-0.20.5-0.1
Number of licking bursts1.11.32.60.11.10.3-0.11.50.51.6-1.2-1.6-1.3-1.2-1.2-1.5
Context. condit. distance diff. score2.63.18.9-1.70.5-0.60.91.6-1.11.7-1.8-2.0-1.9-3.0-1.3-2.8
Locomotion velocity, session 11.51.62.7-0.2-1.0-0.70.8-1.4-1.2-1.51.31.51.41.31.51.7
Locomotion distance, session 10.30.41.90.90.50.6-0.50.10.1-0.20.20.30.31.40.51.1
Locomotion velocity, session 20.30.41.60.70.30.4-0.5-0.30.4-0.20.10.50.41.10.41.3
Locomotion distance, session 20.91.25.71.60.71.0-0.80.20.7-0.40.30.60.52.40.81.8
Locomotion velocity, session 30.20.30.8-0.8-0.0-0.50.40.1-0.70.2-0.7-0.2-0.6-0.9-0.1-0.5
Locomotion distance, session 30.80.91.9-0.60.6-0.10.21.0-0.41.0-1.3-1.0-1.3-1.4-0.7-1.3
Stereotopy head waving bouts, day 30.91.12.2-0.6-1.2-1.10.6-1.5-0.6-1.21.11.21.20.41.01.2
Stereotopy head waving duration, day 31.21.42.3-0.1-1.1-0.70.5-1.4-0.4-1.41.51.41.51.21.31.5
Locomotion velocity, session 75.76.214.6-1.51.60.00.22.6-0.22.9-3.2-2.8-3.1-3.8-2.4-3.6
Locomotion distance, session 73.24.110.5-1.51.0-0.20.52.2-0.32.2-2.5-2.0-2.5-3.2-1.8-3.0
Stereotopy head waving bouts, day 70.40.41.60.80.30.3-0.6-0.40.4-0.30.20.40.41.20.41.3
Stereotopy head waving duration, day 70.40.51.70.4-0.3-0.2-0.1-0.9-0.1-0.80.80.70.91.00.61.3
Locomotion velocity, session 80.40.51.0-0.40.6-0.20.21.0-0.30.8-1.0-1.0-0.9-0.8-0.4-0.8
Locomotion distance, session 81.21.74.10.31.61.0-0.52.00.31.6-1.7-1.7-1.7-0.6-0.9-1.2
Degree of sensitization distance1.01.03.3-1.00.4-0.30.51.0-0.11.1-1.1-0.9-1.0-1.8-0.8-1.5
Degree of sensitization stereotypy0.20.20.60.80.60.4-0.50.20.40.2-0.3-0.2-0.10.6-0.20.4
Conditioned locomotion0.20.30.7-0.8-0.5-0.60.6-0.4-0.7-0.20.10.00.0-0.8-0.1-0.6
Cocaine response after cond. corrected1.71.94.5-2.1-1.6-2.11.9-1.3-1.8-1.00.70.90.7-1.10.9-0.1
Cocaine response after cond. not corrected0.60.61.8-1.3-0.8-1.11.1-0.5-1.2-0.40.20.40.2-0.80.5-0.2
Cocaine response before conditioning2.42.96.22.32.22.5-2.21.91.91.6-1.3-1.4-1.20.9-1.3-0.3
Saline control response1.01.33.21.11.50.8-0.71.80.31.3-1.2-1.3-1.3-0.0-1.1-1.0
Bone: connectivity density0.60.91.41.01.01.2-1.01.21.10.9-0.6-0.8-0.8-0.2-1.2-0.9
Bone: cortical apparent density0.91.23.3-1.7-1.0-1.71.4-0.6-1.5-0.10.10.00.1-1.8-0.2-1.0
Bone: cortical area0.00.10.1-0.1-0.10.3-0.10.1-0.30.10.30.10.30.30.30.3
Bone: cortical porosity1.31.44.62.11.21.9-1.70.71.50.3-0.2-0.4-0.21.6-0.50.4
Bone: cortical porosity1.01.13.61.90.91.8-1.50.61.20.20.1-0.3-0.01.5-0.30.4
Bone: cortical thickness0.20.40.80.30.70.5-0.40.80.40.9-0.5-0.8-0.6-0.4-0.7-0.6
Bone: cortical thickness0.40.51.4-0.80.4-0.50.60.6-0.30.9-0.7-0.7-0.7-1.2-0.4-0.8
Bone: cortical tissue density1.01.33.4-1.8-1.1-1.81.5-0.7-1.6-0.10.20.00.1-1.8-0.1-1.0
Condit. Reinf. active minus inactive responses0.60.72.71.50.80.9-1.2-0.21.60.1-0.10.0-0.11.0-0.50.6
Condit. Reinf. active-inactive response ratio0.90.92.6-0.4-1.3-0.70.4-1.6-0.0-1.21.21.11.20.30.70.9
Condit. Reinf. active responses2.02.45.92.42.01.8-2.01.02.41.2-1.2-0.9-1.11.0-1.30.1
Condit. Reinf. inactive responses4.55.410.23.03.22.7-2.62.52.52.2-2.3-2.0-2.20.9-2.0-0.8
Incentive salience index mean3.03.69.93.02.12.5-2.70.93.11.1-1.2-0.9-1.11.3-1.60.2
Condit. Reinf. lever presses5.47.314.13.83.23.5-3.72.13.72.0-2.3-1.9-2.11.1-2.5-0.6
Condit. Reinf. active minus inactive responses0.30.40.80.50.70.4-0.70.40.80.9-0.6-0.7-0.6-0.4-0.9-0.4
Condit. Reinf. active-inactive response ratio0.00.10.2-0.20.20.1-0.20.2-0.10.4-0.2-0.2-0.2-0.3-0.2-0.2
Condit. Reinf. active responses0.70.91.60.71.10.8-0.91.01.01.3-1.0-1.1-0.9-0.5-1.2-0.8
Condit. Reinf. inactive responses1.31.62.51.11.61.1-1.11.51.31.6-1.3-1.4-1.3-0.4-1.5-1.0
Condit. Reinf. lever presses1.52.05.32.21.52.3-2.20.72.10.7-0.5-0.6-0.51.3-0.80.4
Condit. Reinf. lever reinforcers received0.91.21.81.01.41.2-1.21.21.21.4-1.1-1.2-1.1-0.3-1.3-0.7
Conditioned reinforcement - actives0.80.83.0-1.7-0.8-1.11.3-0.3-1.00.10.0-0.20.0-1.60.0-0.7
Conditioned reinforcement - inactives1.71.92.51.31.51.6-1.41.51.61.4-1.5-1.6-1.5-0.3-1.5-1.0
Conditioned locomotion0.10.10.2-0.0-0.40.50.1-0.30.3-0.20.50.10.40.30.30.3
Patch foraging indifference point 0 sec4.06.410.33.13.23.2-3.02.33.02.5-2.4-2.4-2.30.6-2.4-0.8
Patch foraging indifference point AUC1.61.84.1-2.0-1.6-1.61.6-0.9-2.0-0.81.11.11.2-0.51.40.7
Delay disc. indifference point, 0s delay0.80.92.31.1-0.30.7-1.1-0.90.8-0.80.80.90.81.50.51.3
Delay disc. indifference point, 16s delay0.10.10.50.50.20.4-0.20.50.10.20.2-0.10.10.70.20.3
Delay disc. indifference point, 2s delay2.22.44.2-0.1-1.7-0.1-0.0-1.9-0.2-1.91.91.92.01.61.72.1
Delay disc. indifference point, 24s delay0.00.00.1-0.3-0.2-0.10.30.1-0.3-0.10.20.10.20.00.30.1
Delay disc. indifference point, 4s delay0.60.61.1-0.3-0.9-0.20.2-0.9-0.3-0.81.01.01.00.70.91.0
Delay disc. indifference point, 8s delay0.80.91.60.91.11.1-0.81.30.90.9-1.0-1.0-1.00.2-0.7-0.5
Indifference point function ln k1.72.35.52.11.71.9-1.91.12.30.9-1.2-1.3-1.30.5-1.6-0.8
Indifference point function log k1.72.35.52.11.71.9-1.91.12.30.9-1.2-1.3-1.30.5-1.6-0.8
Patch foraging total patch changes 0 sec3.86.110.23.13.23.1-2.82.42.92.4-2.3-2.4-2.20.6-2.4-0.8
Patch foraging total patch changes 12 sec0.70.92.01.31.41.3-1.21.00.71.0-0.9-0.8-0.70.7-0.60.4
Patch foraging total patch changes 18 sec0.91.22.50.21.30.4-0.21.50.31.6-1.6-1.4-1.4-0.8-1.0-0.9
Patch foraging total patch changes 24 sec1.31.53.01.71.71.5-1.41.41.01.3-1.1-1.1-1.10.6-1.0-0.1
Patch foraging total patch changes 6 sec2.03.05.30.71.90.9-0.92.10.82.3-2.1-2.3-2.1-1.3-2.0-1.7
Patch foraging time to switch 0 sec0.00.10.20.3-0.20.1-0.3-0.4-0.2-0.40.20.40.20.30.10.2
Patch foraging water rate 0 sec0.81.32.91.11.50.9-0.71.71.11.3-1.1-1.4-1.1-0.0-1.1-0.8
Patch foraging water rate 12 sec0.10.10.70.2-0.0-0.1-0.1-0.10.8-0.10.3-0.10.2-0.2-0.3-0.1
Patch foraging water rate 18 sec0.10.20.7-0.4-0.0-0.40.50.30.40.2-0.1-0.6-0.2-0.8-0.4-0.8
Patch foraging water rate 24 sec1.21.73.6-0.50.9-0.60.61.6-0.11.6-1.4-1.6-1.5-1.8-1.2-1.9
Patch foraging water rate 6 sec0.10.10.30.1-0.0-0.40.50.20.3-0.40.40.10.30.50.50.2
Seeking ratio, delayed vs. immediate footshock0.30.41.50.6-0.20.4-0.9-1.20.9-0.50.40.50.50.3-0.30.7
Distance traveled before self-admin1.82.03.4-0.0-1.3-0.40.6-1.3-0.4-1.71.81.71.81.71.71.8
Distance traveled after self-admin3.23.67.0-2.1-2.6-1.72.1-2.0-1.8-1.92.11.92.00.02.01.1
Extensor digitorum longus weight5.220.528.4-2.8-5.1-4.24.2-4.8-4.5-5.25.24.95.02.55.34.0
Bone: elastic displacement0.30.31.11.00.50.3-0.20.00.8-0.10.10.20.11.10.10.7
Bone: elastic work0.81.04.11.70.91.1-1.00.30.9-0.10.30.30.42.00.41.2
Bone: endosteal estimation0.30.61.2-0.0-0.50.3-0.1-0.6-0.4-0.80.90.90.91.01.01.1
Bone: endosteal perimeter0.51.02.4-0.1-0.90.2-0.2-1.2-0.4-1.11.01.21.21.21.21.6
Epididymis fat weight1.63.65.61.42.12.0-2.01.92.41.9-2.1-1.8-1.9-0.9-2.3-1.5
Delta time in closed arm before/after self-admin0.20.20.50.2-0.30.6-0.7-0.60.6-0.50.40.40.40.40.20.5
Delta time in open arm before/after self-admin0.10.10.3-0.00.50.20.10.30.20.3-0.5-0.2-0.4-0.2-0.2-0.2
Diff in mean of infusions in LGA sessions0.80.93.7-0.9-0.1-1.91.90.2-1.7-0.1-0.20.0-0.2-0.50.5-0.2
Delay discount exponential model param0.30.30.9-0.7-0.3-0.90.7-0.4-0.6-0.1-0.00.0-0.0-0.9-0.2-0.5
Extinction: sum of active levers before priming1.51.53.40.41.40.5-0.41.80.41.4-1.7-1.5-1.6-0.7-1.1-1.3
Active lever presses in extinction session 61.01.01.8-0.01.00.0-0.11.30.01.3-1.2-1.3-1.2-1.1-1.0-1.3
Bone: final force0.61.02.01.01.41.3-1.21.30.61.2-0.9-1.1-0.9-0.0-1.0-0.7
Bone: final moment0.50.91.81.21.31.3-1.31.00.70.9-0.6-0.8-0.60.4-0.8-0.3
Food consumed during 24 hour testing period0.30.31.30.80.31.1-0.90.10.70.10.1-0.10.10.90.00.5
Glucose0.71.03.2-1.8-0.5-1.21.60.6-1.40.5-0.2-0.5-0.2-1.30.5-0.7
Heart weight0.10.10.60.30.00.5-0.6-0.30.8-0.20.20.20.20.40.10.4
Delay discount hyperbolic model param0.30.31.3-0.60.1-0.70.50.1-0.40.3-0.4-0.4-0.5-1.2-0.6-0.9
Intermittent access intake day 1-15 change2.52.53.91.11.81.1-1.21.81.11.7-1.9-1.8-1.9-0.9-2.0-1.6
Intermittent access intake escalation2.22.23.50.81.70.7-0.81.80.61.7-1.9-1.8-1.9-1.1-1.8-1.6
Intermittent access intake escalation 20.40.40.90.20.50.3-0.40.50.40.7-0.7-0.7-0.7-0.7-0.9-0.7
Intermitt. access day 1 inactive lever presses1.01.02.00.81.10.4-0.71.00.71.2-1.3-1.2-1.3-0.7-1.4-1.0
Intermitt. access day 15 inactive lever presses1.11.32.31.31.51.0-1.11.01.11.0-1.4-1.2-1.3-0.0-1.2-0.6
Intermitt. access escalation Index0.30.30.6-0.5-0.5-0.80.7-0.2-0.7-0.40.60.50.50.20.70.4
Intermittent access day 1 total infusions1.61.84.20.71.60.8-0.42.00.71.8-1.6-1.8-1.6-0.5-1.1-1.4
Intermittent access day 15 total infusions2.73.15.20.92.00.9-0.82.30.92.2-2.1-2.3-2.1-1.1-1.9-1.9
Intermittent access terminal intake (last 3 days)1.41.63.00.31.30.5-0.41.70.41.6-1.5-1.7-1.5-1.0-1.3-1.5
Intermittent access total infusions2.93.26.10.72.00.9-0.62.50.82.3-2.1-2.4-2.2-1.2-1.8-2.0
Intermittent access day 1 locomotion2.93.05.11.42.11.6-1.22.31.52.0-1.8-2.1-1.9-0.4-1.8-1.6
Intermittent access day 15 total locomotion1.41.63.30.11.30.4-0.21.50.41.5-1.8-1.6-1.7-1.2-1.3-1.4
Intermittent access total locomotion2.32.64.71.11.91.3-0.92.21.21.9-2.0-2.0-1.9-0.6-1.6-1.4
Intermittent access standard deviation1.01.02.30.61.20.1-0.31.50.11.3-1.2-1.4-1.2-0.5-1.0-1.0
Left kidney weight1.54.39.22.82.23.0-3.01.53.01.3-1.6-1.4-1.60.8-1.9-0.7
Right kidney weight2.77.720.74.02.74.4-4.61.44.21.3-1.6-1.5-1.61.6-2.4-0.5
Cocaine induced anxiety2.12.46.41.3-0.60.7-0.9-1.40.9-1.71.71.71.72.51.22.2
Post-drug Anxiety0.40.41.81.00.30.8-1.2-0.41.3-0.10.00.10.00.4-0.60.3
Baseline Anxiety2.52.64.30.31.60.6-0.61.90.72.0-2.1-2.0-2.1-1.7-1.9-2.0
Tail length1.03.15.72.12.22.3-2.41.72.01.5-1.7-1.6-1.60.4-1.6-0.7
Length with tail0.41.34.82.21.31.5-1.60.61.60.5-0.5-0.6-0.51.0-1.10.1
Length without tail0.51.12.20.7-0.9-0.30.2-1.30.0-1.31.51.21.41.30.61.2
Times rat made contact with spout3.13.66.60.62.11.2-0.82.60.52.5-2.2-2.6-2.2-1.4-1.9-2.1
Lifetime Intake2.22.45.00.71.70.9-0.62.20.72.0-1.8-2.1-1.8-0.9-1.6-1.8
Liver weight, left0.20.20.80.0-0.3-0.60.4-0.9-0.2-0.40.30.60.40.40.40.8
Liver weight, right0.10.20.6-0.4-0.0-0.60.80.2-0.80.0-0.0-0.1-0.1-0.00.5-0.1
Locomotor activity3.35.216.12.2-0.91.0-0.9-1.90.8-2.32.92.32.84.01.93.1
Locomotor testing distance1.72.910.82.70.21.5-1.5-0.81.5-1.11.61.21.53.30.72.2
Locomotor testing rearing2.13.311.63.10.81.9-2.0-0.41.8-0.71.21.01.23.40.42.2
Locomotion in novel chamber0.40.51.31.20.90.9-0.80.90.70.3-0.4-0.4-0.41.0-0.10.0
Locomotion in novel chamber post-restriction0.20.20.7-0.8-0.3-0.60.5-0.0-0.7-0.50.10.30.2-0.10.70.3
Fecal boli incidents, locomotor time 10.30.31.20.90.70.4-0.30.80.10.30.2-0.40.11.10.30.3
Change in fecal boli incidents, locomotor task0.90.92.7-0.8-1.2-0.80.7-1.6-0.4-1.10.91.21.0-0.10.60.9
Time >=10cm from walls, locomotor time 10.50.51.51.20.81.0-1.00.41.10.5-0.1-0.5-0.20.5-0.7-0.2
Bouts of movement, locomotor time 10.80.81.6-1.0-1.1-1.31.2-0.8-1.1-0.91.10.60.9-0.40.60.1
Total resting periods, locomotor time 11.11.22.3-1.3-1.2-1.51.5-1.0-1.3-1.01.20.81.1-0.50.80.2
Rest time, locomotor task time 11.92.13.3-1.0-1.5-1.41.3-1.5-1.3-1.81.71.61.70.81.81.2
Distance moved, locomotor task time 11.11.22.40.51.00.8-0.70.90.91.4-1.5-1.1-1.4-1.0-1.5-1.1
Vertical activity count, locomotor time 10.20.20.40.3-0.6-0.20.1-0.6-0.2-0.40.60.60.60.60.40.5
Time >=10cm from walls, locomotor time 21.71.83.9-0.3-1.4-0.80.5-1.6-0.7-1.72.01.61.91.11.41.4
Bouts of movement, locomotor time 20.91.02.9-1.3-0.7-1.71.7-0.3-1.5-0.50.70.50.6-0.50.80.1
Total resting periods, locomotor time 20.80.82.8-1.2-0.5-1.61.7-0.0-1.5-0.30.50.20.4-0.50.7-0.1
Rest time, locomotor task time 20.50.51.8-0.90.1-1.01.30.7-1.30.2-0.3-0.3-0.3-0.30.6-0.5
Distance moved, locomotor task time 20.70.81.91.30.81.2-1.40.41.30.8-0.6-0.5-0.60.2-1.0-0.2
Vertical activity count, locomotor time 21.21.32.30.0-1.1-0.40.3-1.4-0.5-1.41.41.51.41.31.31.4
Light reinforcement 12.03.66.40.31.91.1-0.82.30.52.3-2.3-2.5-2.3-1.9-2.2-2.3
Light reinforcement 21.62.17.5-1.50.2-0.50.61.2-0.81.3-1.3-1.6-1.4-2.7-1.3-2.4
Bone: marrow area0.20.51.10.1-0.40.4-0.3-0.5-0.2-0.70.80.80.81.10.91.1
Bone: maximum diameter0.40.81.4-1.2-1.1-0.70.8-0.8-1.1-0.70.90.91.00.01.10.8
Bone: maximum force0.20.41.10.91.01.1-0.90.80.20.5-0.3-0.4-0.30.7-0.10.2
Bone: maximum moment0.30.61.51.21.01.2-1.10.60.30.4-0.1-0.2-0.11.1-0.00.5
Mean time between licks in bursts0.10.10.30.00.60.4-0.40.20.40.2-0.5-0.2-0.3-0.2-0.20.1
Mean num. licks in bursts0.10.10.20.20.40.3-0.20.4-0.40.2-0.3-0.2-0.30.1-0.1-0.1
Cd content in liver0.30.30.7-0.20.4-0.10.10.5-0.00.7-0.7-0.7-0.6-0.8-0.6-0.7
Co content in liver3.94.69.4-3.0-2.6-2.73.1-1.5-2.9-1.71.71.51.7-0.72.20.7
Cu content in liver1.21.52.1-1.1-1.3-1.41.4-1.4-1.2-1.11.21.21.20.21.31.1
Fe content in liver0.20.20.50.30.50.4-0.70.00.60.5-0.6-0.4-0.5-0.4-0.7-0.3
K content in liver0.70.71.40.10.70.8-0.60.80.70.9-1.0-1.1-1.0-0.8-1.0-1.2
Mg content in liver0.10.10.4-0.7-0.2-0.10.30.0-0.30.2-0.2-0.3-0.2-0.60.0-0.4
Mn content in liver0.10.10.5-0.7-0.5-0.00.40.1-0.1-0.10.2-0.10.1-0.40.3-0.2
Na content in liver2.62.79.22.20.21.7-1.7-0.81.8-1.21.11.21.23.00.82.2
Rb content in liver0.30.41.2-0.20.3-0.20.10.50.20.6-0.6-0.8-0.7-1.1-0.8-1.0
Se content in liver1.72.15.51.1-0.70.4-0.5-1.20.8-1.71.51.71.62.31.32.2
Sr content in liver0.30.30.8-0.1-0.4-0.20.1-0.7-0.3-0.50.50.70.60.60.70.9
Zn content in liver1.11.24.61.3-0.10.8-0.8-0.70.7-1.00.91.11.02.10.91.6
Bone: minimum diameter0.20.41.40.70.10.8-0.6-0.20.0-0.10.70.40.71.20.51.0
Time in familiar zone, hab. session 11.01.01.70.31.00.9-0.81.30.21.0-1.3-1.2-1.3-0.6-0.9-1.1
Time in novel zone, hab. session 14.24.17.6-2.1-2.2-2.82.6-2.2-2.2-1.71.91.92.0-0.11.91.4
Total zone transitions, hab. session 10.30.41.40.3-0.20.00.0-0.5-0.4-0.70.50.80.61.10.81.2
Total locomotion distance, hab. session 10.50.72.61.20.50.8-0.9-0.20.5-0.30.00.70.31.60.41.4
Locomotion velocity, hab. session 11.01.54.92.11.11.6-1.60.31.2-0.1-0.10.40.12.20.11.4
Time in familiar zone, hab. session 21.11.22.2-1.4-1.5-1.41.5-0.7-1.4-0.91.10.60.9-0.50.9-0.3
Time in novel zone, hab. session 20.20.20.50.50.70.3-0.30.20.20.3-0.6-0.1-0.30.5-0.00.7
Total zone transitions, hab. session 21.01.34.41.0-0.30.1-0.2-0.90.0-1.21.21.11.32.11.11.9
Total locomotion distance, hab. session 20.50.62.71.00.20.2-0.3-0.4-0.1-0.60.60.70.71.60.71.5
Locomotion velocity, hab. session 20.81.14.31.10.00.3-0.3-0.6-0.0-0.90.91.01.02.11.01.9
Novel to familiar place preference ratio1.31.32.81.21.70.9-1.01.41.21.6-1.2-1.3-1.10.1-1.1-0.2
Novelty place preference1.51.63.21.31.81.0-1.11.51.21.6-1.3-1.4-1.20.0-1.2-0.3
Time in novel zone, NPP test1.11.12.31.01.50.7-0.91.31.01.4-1.1-1.2-1.00.1-0.9-0.1
Total zone transitions, NPP test0.30.51.51.20.90.8-0.70.50.80.3-0.2-0.2-0.11.1-0.10.6
Total locomotion distance, NPP test0.91.32.91.71.71.4-1.31.21.11.0-0.9-0.8-0.80.9-0.70.1
Locomotion velocity, NPP test1.21.73.51.91.91.5-1.51.51.31.3-1.1-1.1-1.00.7-1.1-0.2
Intraocular pressure0.81.22.70.51.40.3-0.41.20.81.7-1.4-1.3-1.3-0.7-1.2-0.8
Delta distance traveled before/after self-admin1.82.05.8-2.4-1.6-2.02.1-0.8-2.0-0.50.60.50.5-1.60.7-0.4
Delta ambulatory time before/after self-admin1.01.02.9-1.7-1.2-1.41.5-0.6-1.5-0.30.50.40.4-1.20.5-0.3
Parametrial fat weight0.71.43.3-0.40.90.1-0.31.10.31.4-1.4-1.3-1.4-1.8-1.4-1.5
Pavlov. Cond. lever latency2.93.65.3-2.3-2.3-2.22.2-1.9-2.3-1.91.61.91.7-0.12.11.2
Pavlov. Cond. magazine entry latency1.01.21.90.81.20.9-1.01.30.71.2-1.3-1.3-1.3-0.6-1.4-1.2
Pavlov. Cond. change in total contacts1.41.52.91.71.51.2-1.31.31.71.2-0.9-1.0-1.00.4-1.2-0.4
Pavlov. Cond. index score2.73.44.82.12.22.0-2.02.02.01.8-1.7-1.9-1.8-0.0-2.0-1.3
Pavlov. Cond. latency score3.34.26.02.32.42.2-2.32.12.32.1-1.9-2.1-2.0-0.1-2.3-1.4
Pavlov. Cond. lever contacts3.13.65.82.32.22.2-2.21.92.41.8-1.6-1.8-1.70.1-2.1-1.2
Pavlov. Cond. magazine entry number0.40.51.0-0.6-0.7-0.60.5-1.0-0.6-0.70.70.80.70.20.70.6
Pavlov. Cond. intertrial magazine entries1.01.23.31.81.21.6-1.60.51.70.5-0.5-0.4-0.50.9-0.90.0
Pavlov. Cond. lever-magazine prob. diff.2.22.73.81.92.01.8-1.81.81.81.6-1.5-1.6-1.60.1-1.7-1.1
Pavlov. Cond. response bias0.81.01.51.21.01.1-1.21.01.20.8-0.8-1.0-0.9-0.0-1.1-0.9
Pavlov. Cond. lever latency0.81.12.9-1.7-0.6-1.61.50.0-1.50.1-0.5-0.2-0.4-1.7-0.0-0.9
Pavlov. Cond. magazine entry latency1.01.13.61.70.81.9-1.50.71.30.10.2-0.20.01.6-0.10.4
Pavlov. Cond. change in total contacts1.52.03.80.5-1.10.2-0.2-1.60.4-1.71.91.61.91.91.41.9
Pavlov. Cond. index score1.11.44.71.80.31.6-1.4-0.11.3-0.60.80.50.72.20.41.1
Pavlov. Cond. latency score1.21.54.91.90.41.8-1.6-0.21.6-0.60.80.50.72.20.31.2
Pavlov. Cond. lever contacts1.21.65.22.00.61.8-1.7-0.11.5-0.40.70.40.72.30.31.4
Pavlov. Cond. magazine entry number0.70.93.1-1.4-0.7-1.81.4-0.6-1.2-0.2-0.00.30.1-1.20.2-0.2
Pavlov. Cond. intertrial magazine entries3.54.57.60.72.31.4-1.32.51.52.8-2.6-2.5-2.5-1.7-2.4-2.2
Pavlov. Cond. lever-magazine prob. diff.1.01.24.11.50.21.5-1.2-0.31.3-0.70.90.60.82.00.51.2
Pavlov. Cond. response bias1.31.76.12.00.71.8-1.60.01.4-0.40.80.40.72.50.51.4
Time in closed arm before self-admin0.10.10.5-0.3-0.7-0.00.1-0.5-0.1-0.40.40.40.4-0.10.20.1
Time in closed arm after self-admin0.20.20.6-0.2-0.8-0.20.1-0.8-0.2-0.70.60.60.60.30.40.4
Time in open arm before self-admin0.40.41.1-0.7-0.6-1.00.9-0.4-1.0-0.40.60.60.60.10.80.4
Time in open arm after self-admin0.10.10.2-0.4-0.1-0.10.4-0.1-0.1-0.30.10.30.20.10.40.3
Bone: periosteal estimation0.20.40.7-0.2-0.50.3-0.1-0.5-0.4-0.50.80.70.80.70.90.9
Bone: periosteal perimeter0.20.30.6-0.4-0.5-0.00.1-0.6-0.4-0.40.60.60.70.40.70.8
Bone: post-yield work0.60.81.4-0.50.70.3-0.01.2-0.31.2-1.1-1.1-1.1-1.1-0.7-1.2
Progressive ratio test 1 active lever presses1.01.01.9-0.60.6-0.40.71.4-0.51.3-1.0-1.3-1.1-1.3-0.7-1.4
Progressive ratio test 1 breakpoint1.11.22.4-0.80.6-0.50.81.4-0.61.3-1.1-1.3-1.1-1.5-0.7-1.5
Progressive ratio test 1 inactive lever presses4.65.08.50.62.30.5-0.62.80.62.9-2.8-2.9-2.8-2.0-2.6-2.7
Progressive ratio test 2 active lever presses2.32.54.8-1.01.2-0.20.62.0-0.41.9-1.8-2.0-1.8-2.2-1.2-2.2
Progressive ratio test 2 breakpoint2.52.85.2-0.51.60.20.22.30.12.1-2.1-2.2-2.1-1.9-1.5-2.2
Progressive ratio test 2 inactive lever presses2.12.44.20.71.90.9-0.72.00.81.9-1.9-2.0-1.9-0.9-1.6-1.6
Incentive Sensitization - Responses1.41.42.4-0.21.20.7-0.31.60.61.5-1.4-1.5-1.4-1.3-1.2-1.5
Incentive Sensitization - Breakpoint1.81.83.00.01.41.0-0.61.70.81.6-1.6-1.7-1.6-1.3-1.4-1.6
Sum of active levers in priming session hrs 5-62.01.95.6-2.4-1.4-2.11.9-0.9-2.1-0.60.40.50.5-1.50.8-0.2
Progressive ratio0.70.82.2-1.3-0.3-1.21.50.6-1.20.6-0.3-0.5-0.4-1.30.1-1.1
Food seeking constrained by brief footshock5.06.216.6-3.6-2.6-4.13.9-1.4-3.8-1.31.51.01.3-1.81.8-0.2
Seeking ratio, punishment vs. effort0.81.02.4-0.7-1.3-0.80.5-1.5-0.6-1.31.21.11.20.20.80.9
Retroperitoneal fat weight0.41.22.40.30.80.5-0.41.01.11.3-1.2-1.1-1.2-1.3-1.5-1.4
Reaction time number correct1.42.04.9-2.2-1.8-2.12.2-1.1-1.5-0.81.10.71.0-1.11.1-0.0
Reaction time mean minus median0.91.24.21.7-0.00.7-1.0-0.80.7-0.70.91.10.92.10.41.5
Reaction time mean minus median AUC0.30.41.41.10.00.7-0.8-0.30.5-0.20.40.50.41.20.10.8
Reaction time num false alarms0.10.10.30.0-0.20.6-0.3-0.20.40.20.10.20.10.30.20.2
Reaction time num false alarms AUC0.10.10.60.0-0.10.8-0.4-0.10.60.4-0.20.1-0.10.1-0.00.0
Reaction time trials correct on left1.42.04.9-2.2-1.8-2.12.2-1.1-1.5-0.81.10.71.0-1.11.1-0.0
Reaction time trials on left1.31.94.7-2.2-1.7-2.02.1-1.0-1.5-0.71.00.60.9-1.11.0-0.1
Reaction time mean1.01.43.91.3-0.40.8-1.1-1.10.8-1.30.91.41.02.00.71.6
Reaction time mean AUC1.31.84.81.2-0.60.7-0.9-1.40.6-1.51.21.71.22.21.01.9
Median of all reaction times0.71.02.40.9-0.50.7-0.9-1.00.7-1.20.71.30.81.50.61.3
Reaction time omissions0.30.41.11.00.60.8-1.00.10.90.4-0.4-0.2-0.30.3-0.70.2
Reaction time false alarm rate0.50.82.30.90.81.5-1.20.71.10.9-0.8-0.5-0.70.3-0.6-0.2
Reaction time premature initiation rate0.40.51.5-0.9-0.9-1.20.8-0.8-0.3-0.30.5-0.00.4-1.2-0.3-0.5
Reaction time premature initiations1.41.94.9-2.1-1.9-2.21.9-1.3-1.2-0.71.10.40.9-1.70.3-0.5
Std. dev. reaction times0.91.23.41.2-0.50.4-0.7-1.20.4-0.91.11.31.21.80.61.7
Reaction time trials completed1.31.94.7-2.2-1.7-2.02.1-1.0-1.5-0.71.00.60.9-1.11.0-0.1
Reaction time trials AUC1.42.04.9-2.2-1.8-2.12.2-1.1-1.6-0.81.10.71.0-1.11.1-0.0
Run reversals in cocaine runway, females0.20.20.4-0.50.20.40.10.6-0.10.4-0.5-0.3-0.5-0.6-0.1-0.6
Run reversals in cocaine runway, males0.20.20.90.60.60.20.00.9-0.10.0-0.1-0.2-0.11.00.50.3
Latency to leave start box in cocaine runway1.71.93.1-0.6-1.4-1.11.0-1.7-0.9-1.81.71.61.70.91.41.6
Latency to leave start box in cocaine runway, F0.60.71.2-0.2-0.7-0.80.7-1.0-0.8-0.90.91.01.00.60.91.1
Latency to leave start box in cocaine runway, M0.20.20.60.0-0.40.10.1-0.30.0-0.80.60.30.50.40.40.4
Std. dev. time between licks in bursts1.51.85.02.01.42.0-2.20.12.10.3-0.5-0.2-0.31.3-0.71.0
Total sessions with >9 infusions0.30.30.6-0.00.20.4-0.20.60.50.8-0.4-0.8-0.5-0.6-0.7-0.8
Short access day 1 total inactive lever presses4.34.89.41.52.91.6-1.23.11.22.6-2.6-2.7-2.7-0.6-2.0-2.0
Short access day 10 total inactive lever presses0.91.01.90.41.00.4-0.41.20.41.4-1.1-1.3-1.2-0.9-1.3-1.2
Short access day 1 total infusions0.30.41.0-0.20.2-0.00.10.8-0.11.0-0.3-0.9-0.4-0.8-0.5-1.0
Short access day 10 total infusions1.01.12.81.31.41.1-0.81.70.71.1-0.8-1.3-0.90.6-0.6-0.5
Short access total infusions1.71.94.20.81.51.0-0.82.00.81.8-1.4-1.9-1.5-0.6-1.4-1.6
Short access day 1 locomotion0.50.51.41.1-0.10.9-0.8-0.31.0-0.20.70.20.61.20.10.6
Short access day 10 total locomotion0.60.72.41.20.61.5-1.20.51.50.2-0.3-0.3-0.30.8-0.40.1
Short access total locomotion1.51.53.61.71.21.8-1.61.01.91.0-0.7-1.0-0.80.5-1.2-0.5
One hour access (0.3 mA shock)0.70.82.20.41.10.3-0.11.50.11.2-1.0-1.3-1.1-0.4-0.7-1.0
Compulsive drug intake0.50.51.71.31.00.9-1.10.50.80.3-0.3-0.3-0.31.0-0.20.2
One hour access (shock baseline)0.30.31.1-0.8-0.3-0.81.00.3-0.80.30.0-0.3-0.0-0.70.1-0.5
Social response proportion2.22.46.0-2.4-2.1-2.01.9-1.5-2.2-0.90.90.70.9-1.60.80.1
Social responses0.30.41.2-1.0-0.9-0.50.4-0.9-0.4-0.30.40.20.4-1.1-0.1-0.0
Social time0.30.51.31.10.41.0-1.2-0.30.8-0.2-0.00.30.10.9-0.20.7
Soleus weight3.911.516.0-2.9-4.0-3.83.9-3.4-3.5-3.63.73.43.60.93.82.5
Bone: stiffness0.30.51.20.70.91.1-1.10.80.30.8-0.6-0.8-0.60.1-0.6-0.4
Tibialis anterior weight3.010.415.0-1.6-3.6-2.72.8-3.5-3.2-3.73.93.53.72.23.82.9
Time to tail flick, vehicle, before self-admin3.94.07.01.32.51.1-0.92.61.12.5-2.5-2.4-2.5-1.0-2.1-2.0
Time to tail flick, vehicle, after self-admin1.21.23.9-1.5-0.6-2.01.8-0.0-1.80.2-0.2-0.2-0.2-1.50.1-0.8
Time to tail flick, test, before self-admin0.40.41.50.90.71.2-0.80.51.00.2-0.3-0.2-0.30.8-0.10.2
Time to tail flick, test, after self-admin1.71.83.10.21.01.0-0.81.11.11.6-1.6-1.5-1.5-1.5-1.7-1.6
Delta time to tail flick, vehicle, before/after SA1.21.23.5-1.6-1.2-1.91.6-0.7-1.8-0.50.60.40.6-0.90.7-0.1
Delta time to tail flick, test, before/after SA0.80.73.4-1.0-0.2-0.40.30.2-0.20.7-0.6-0.8-0.6-1.8-0.9-1.2
Tibia length5.916.729.85.44.85.4-5.54.15.13.4-3.2-3.3-3.21.3-3.9-1.6
Ambulatory time before self-admin0.50.51.50.2-0.5-0.10.4-0.3-0.3-0.80.70.70.71.21.11.0
Ambulatory time after self-admin2.83.15.3-1.4-2.3-1.51.8-1.8-1.5-1.92.11.92.00.62.01.3
Bone: tissue strength0.30.31.00.90.61.0-1.00.00.50.1-0.10.0-0.10.8-0.10.5
Total heroin consumption0.30.30.8-0.2-0.2-0.80.9-0.1-0.8-0.50.50.50.50.60.80.5
Bone: trabecular number0.50.81.80.81.21.2-1.01.30.80.9-0.7-0.8-0.8-0.0-0.8-0.6
Bone: trabecular spacing0.91.22.6-0.7-1.2-1.10.8-1.6-1.0-1.31.01.41.10.41.11.0
Bone: trabecular thickness1.11.44.21.01.61.2-0.82.10.41.3-1.0-1.4-1.10.1-0.9-0.9
Bone: trabecular tissue density1.11.52.4-0.8-1.4-1.01.0-1.4-1.5-1.41.51.31.40.61.41.0
Water consumed over 24 hours0.10.10.20.40.30.5-0.20.4-0.00.2-0.0-0.3-0.00.40.10.1
Number of responses in last shaping day0.20.20.3-0.2-0.4-0.20.3-0.4-0.3-0.40.50.50.50.30.60.4