Itgb7

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Itgb7 0.21 0.1 3.7e-07 0.07 0.05 0.08 0.07 1.5e-08 1.2e-06 6.4e-09 4.6e-08
2 Brain gene expression Itgb7 0.16 0.07 9.9e-13 0.13 0.14 0.13 0.14 5.1e-12 7.4e-13 4.8e-12 3.4e-13

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density2.44.15.3-2.3-1.7
Area under the delay curve0.30.30.7-0.0-0.8
BMI with tail1.55.05.2-2.3-2.2
BMI without tail0.10.30.4-0.6-0.4
Body weight0.62.63.4-1.8-1.3
Weight adjusted by age0.30.30.40.40.7
Bone surface4.47.78.6-2.9-2.6
Bone volume3.55.96.5-2.6-2.3
Breakpoint value in progressive ratio session2.93.23.2-1.8-1.8
Number of licking bursts1.11.32.11.40.8
Context. condit. distance diff. score1.51.82.9-1.7-0.8
Locomotion velocity, session 17.68.28.42.82.9
Locomotion distance, session 15.06.46.82.42.6
Locomotion velocity, session 24.14.84.82.22.2
Locomotion distance, session 24.56.37.62.22.8
Locomotion velocity, session 34.04.74.92.12.2
Locomotion distance, session 31.31.42.60.41.6
Stereotopy head waving bouts, day 30.50.60.90.5-0.9
Stereotopy head waving duration, day 30.50.61.01.0-0.4
Locomotion velocity, session 71.61.72.51.61.0
Locomotion distance, session 72.12.72.81.61.7
Stereotopy head waving bouts, day 70.40.40.8-0.2-0.9
Stereotopy head waving duration, day 71.11.32.4-0.4-1.5
Locomotion velocity, session 80.30.40.70.80.3
Locomotion distance, session 81.32.03.30.81.8
Degree of sensitization distance0.30.30.50.7-0.2
Degree of sensitization stereotypy0.90.91.5-0.6-1.2
Conditioned locomotion0.50.61.20.11.1
Cocaine response after cond. corrected1.92.22.41.51.4
Cocaine response after cond. not corrected1.51.61.81.21.3
Cocaine response before conditioning0.10.10.2-0.5-0.1
Saline control response0.60.71.1-1.00.7
Bone: connectivity density0.91.42.5-1.6-0.6
Bone: cortical apparent density1.21.52.31.50.9
Bone: cortical area2.53.85.4-2.3-1.4
Bone: cortical porosity0.70.71.3-1.10.4
Bone: cortical porosity0.70.71.0-1.00.7
Bone: cortical thickness0.40.60.9-0.9-0.6
Bone: cortical thickness1.21.32.60.31.6
Bone: cortical tissue density1.41.82.61.61.0
Condit. Reinf. active minus inactive responses0.91.01.1-1.10.9
Condit. Reinf. active-inactive response ratio0.70.81.3-1.10.6
Condit. Reinf. active responses1.21.42.7-0.41.6
Condit. Reinf. inactive responses2.52.93.91.42.0
Incentive salience index mean0.50.60.6-0.80.7
Condit. Reinf. lever presses0.00.00.0-0.10.1
Condit. Reinf. active minus inactive responses0.50.61.2-0.1-1.1
Condit. Reinf. active-inactive response ratio0.60.61.0-0.4-1.0
Condit. Reinf. active responses0.40.61.10.3-1.0
Condit. Reinf. inactive responses0.30.40.80.90.2
Condit. Reinf. lever presses0.10.20.3-0.10.6
Condit. Reinf. lever reinforcers received0.20.30.30.5-0.5
Conditioned reinforcement - actives2.72.75.42.30.0
Conditioned reinforcement - inactives0.30.30.6-0.10.8
Conditioned locomotion0.50.61.01.0-0.4
Patch foraging indifference point 0 sec1.01.62.21.01.5
Patch foraging indifference point AUC1.82.12.11.51.5
Delay disc. indifference point, 0s delay0.20.20.30.6-0.0
Delay disc. indifference point, 16s delay0.50.50.6-0.7-0.6
Delay disc. indifference point, 2s delay1.81.93.80.2-2.0
Delay disc. indifference point, 24s delay0.20.20.4-0.3-0.6
Delay disc. indifference point, 4s delay0.50.50.9-0.2-1.0
Delay disc. indifference point, 8s delay0.20.20.30.0-0.6
Indifference point function ln k3.54.96.0-2.4-2.0
Indifference point function log k3.54.96.0-2.4-2.0
Patch foraging total patch changes 0 sec1.21.92.90.91.7
Patch foraging total patch changes 12 sec2.43.14.31.42.1
Patch foraging total patch changes 18 sec4.25.46.02.22.5
Patch foraging total patch changes 24 sec0.60.81.20.61.1
Patch foraging total patch changes 6 sec2.63.85.42.31.5
Patch foraging time to switch 0 sec0.60.91.81.30.1
Patch foraging water rate 0 sec0.50.81.6-1.3-0.3
Patch foraging water rate 12 sec1.42.14.2-2.1-0.2
Patch foraging water rate 18 sec0.40.51.0-1.0-0.2
Patch foraging water rate 24 sec0.30.50.6-0.6-0.8
Patch foraging water rate 6 sec4.66.712.4-3.5-1.0
Seeking ratio, delayed vs. immediate footshock0.00.00.1-0.2-0.0
Distance traveled before self-admin0.30.40.70.8-0.2
Distance traveled after self-admin0.91.01.6-1.3-0.7
Extensor digitorum longus weight4.317.128.9-2.3-5.4
Bone: elastic displacement2.73.14.22.11.4
Bone: elastic work0.40.50.50.70.7
Bone: endosteal estimation3.78.110.9-3.3-2.3
Bone: endosteal perimeter3.26.78.5-2.9-2.2
Epididymis fat weight0.71.61.9-1.11.4
Delta time in closed arm before/after self-admin1.91.83.3-1.8-0.6
Delta time in open arm before/after self-admin3.63.44.11.72.0
Diff in mean of infusions in LGA sessions0.40.40.7-0.8-0.4
Delay discount exponential model param0.60.61.20.11.1
Extinction: sum of active levers before priming2.42.42.5-1.6-1.5
Active lever presses in extinction session 60.30.30.6-0.2-0.7
Bone: final force3.75.97.1-2.7-2.2
Bone: final moment4.97.99.4-3.1-2.5
Food consumed during 24 hour testing period1.72.04.0-2.0-0.2
Glucose0.10.10.10.40.2
Heart weight0.20.30.5-0.70.2
Delay discount hyperbolic model param0.70.81.60.01.2
Intermittent access intake day 1-15 change0.10.10.2-0.2-0.4
Intermittent access intake escalation0.20.20.3-0.2-0.5
Intermittent access intake escalation 20.10.10.2-0.3-0.5
Intermitt. access day 1 inactive lever presses1.41.52.5-1.6-0.6
Intermitt. access day 15 inactive lever presses0.60.61.1-1.10.3
Intermitt. access escalation Index2.21.93.01.7-0.9
Intermittent access day 1 total infusions0.50.60.70.80.7
Intermittent access day 15 total infusions1.31.52.81.70.5
Intermittent access terminal intake (last 3 days)1.01.12.11.5-0.0
Intermittent access total infusions0.70.81.51.20.1
Intermittent access day 1 locomotion0.50.50.60.80.7
Intermittent access day 15 total locomotion0.30.30.5-0.7-0.3
Intermittent access total locomotion0.10.10.10.4-0.1
Intermittent access standard deviation0.50.50.60.70.8
Left kidney weight0.82.33.6-1.9-1.0
Right kidney weight1.23.33.8-1.7-2.0
Cocaine induced anxiety1.21.42.8-0.1-1.7
Post-drug Anxiety4.24.76.7-1.7-2.6
Baseline Anxiety1.92.04.0-2.00.0
Tail length0.20.70.70.80.8
Length with tail0.00.00.1-0.20.1
Length without tail0.40.81.1-1.1-0.7
Times rat made contact with spout0.20.30.5-0.7-0.3
Lifetime Intake0.30.40.70.80.1
Liver weight, left0.71.21.4-1.0-1.2
Liver weight, right1.32.23.9-2.0-0.7
Locomotor activity0.10.10.20.4-0.1
Locomotor testing distance0.30.50.90.90.3
Locomotor testing rearing0.20.40.70.9-0.1
Locomotion in novel chamber1.82.24.4-0.3-2.1
Locomotion in novel chamber post-restriction0.80.91.8-0.2-1.4
Fecal boli incidents, locomotor time 11.61.83.20.61.8
Change in fecal boli incidents, locomotor task0.50.50.8-0.4-0.9
Time >=10cm from walls, locomotor time 10.20.20.3-0.00.6
Bouts of movement, locomotor time 11.21.31.61.01.3
Total resting periods, locomotor time 11.92.12.91.11.7
Rest time, locomotor task time 10.80.81.31.10.6
Distance moved, locomotor task time 10.30.30.5-0.2-0.7
Vertical activity count, locomotor time 10.50.51.0-0.1-1.0
Time >=10cm from walls, locomotor time 20.20.20.40.60.0
Bouts of movement, locomotor time 20.60.71.30.2-1.2
Total resting periods, locomotor time 20.60.61.20.2-1.1
Rest time, locomotor task time 21.11.31.41.21.1
Distance moved, locomotor task time 20.00.00.10.0-0.3
Vertical activity count, locomotor time 20.50.60.70.6-0.9
Light reinforcement 11.73.04.31.32.1
Light reinforcement 21.82.42.91.41.7
Bone: marrow area3.78.110.9-3.3-2.3
Bone: maximum diameter1.01.82.5-1.6-1.0
Bone: maximum force3.86.67.8-2.8-2.3
Bone: maximum moment5.18.710.4-3.2-2.7
Mean time between licks in bursts3.14.47.92.80.9
Mean num. licks in bursts1.51.82.9-1.7-0.8
Cd content in liver0.10.10.10.40.1
Co content in liver0.70.81.2-0.6-1.1
Cu content in liver6.57.99.8-2.4-3.1
Fe content in liver0.80.91.61.20.6
K content in liver0.20.20.40.6-0.0
Mg content in liver0.50.50.91.00.1
Mn content in liver0.10.10.30.5-0.1
Na content in liver0.40.40.70.8-0.2
Rb content in liver0.91.11.2-1.0-1.1
Se content in liver1.72.13.21.81.0
Sr content in liver0.30.30.4-0.60.4
Zn content in liver1.11.22.50.11.6
Bone: minimum diameter3.87.09.7-3.1-2.1
Time in familiar zone, hab. session 10.10.10.20.30.4
Time in novel zone, hab. session 10.40.40.6-0.5-0.8
Total zone transitions, hab. session 11.52.12.21.51.4
Total locomotion distance, hab. session 12.43.44.81.42.2
Locomotion velocity, hab. session 11.92.73.51.41.9
Time in familiar zone, hab. session 22.32.42.6-1.6-1.5
Time in novel zone, hab. session 20.70.71.01.00.7
Total zone transitions, hab. session 21.72.23.21.11.8
Total locomotion distance, hab. session 22.12.85.20.72.3
Locomotion velocity, hab. session 22.12.95.20.72.3
Novel to familiar place preference ratio0.40.40.7-0.8-0.4
Novelty place preference0.30.30.4-0.6-0.4
Time in novel zone, NPP test0.40.40.4-0.7-0.5
Total zone transitions, NPP test5.47.79.52.43.1
Total locomotion distance, NPP test6.08.312.62.03.6
Locomotion velocity, NPP test5.98.413.41.83.7
Intraocular pressure0.20.30.60.8-0.1
Delta distance traveled before/after self-admin2.62.85.5-2.30.2
Delta ambulatory time before/after self-admin3.33.67.2-2.70.1
Parametrial fat weight1.73.46.50.62.5
Pavlov. Cond. lever latency0.60.71.21.10.5
Pavlov. Cond. magazine entry latency2.22.83.3-1.5-1.8
Pavlov. Cond. change in total contacts2.12.22.4-1.5-1.5
Pavlov. Cond. index score2.93.73.7-1.9-1.9
Pavlov. Cond. latency score2.93.74.0-2.0-1.8
Pavlov. Cond. lever contacts0.91.11.3-1.1-0.9
Pavlov. Cond. magazine entry number2.32.83.71.91.4
Pavlov. Cond. intertrial magazine entries3.23.84.01.92.0
Pavlov. Cond. lever-magazine prob. diff.2.53.13.4-1.7-1.9
Pavlov. Cond. response bias1.31.51.8-1.2-1.3
Pavlov. Cond. lever latency0.70.91.7-0.3-1.3
Pavlov. Cond. magazine entry latency1.31.52.70.51.7
Pavlov. Cond. change in total contacts0.20.20.3-0.6-0.4
Pavlov. Cond. index score1.21.52.70.61.6
Pavlov. Cond. latency score1.11.42.60.51.6
Pavlov. Cond. lever contacts1.01.42.70.21.7
Pavlov. Cond. magazine entry number0.30.40.8-0.0-0.9
Pavlov. Cond. intertrial magazine entries0.00.00.0-0.20.2
Pavlov. Cond. lever-magazine prob. diff.0.70.91.70.41.3
Pavlov. Cond. response bias0.60.81.70.11.3
Time in closed arm before self-admin0.60.71.31.10.2
Time in closed arm after self-admin0.30.30.5-0.2-0.7
Time in open arm before self-admin1.11.22.2-0.4-1.5
Time in open arm after self-admin0.40.40.80.30.9
Bone: periosteal estimation4.69.513.0-3.6-2.4
Bone: periosteal perimeter3.76.17.4-2.7-2.2
Bone: post-yield work3.44.66.3-2.5-1.7
Progressive ratio test 1 active lever presses3.13.34.12.01.6
Progressive ratio test 1 breakpoint2.72.83.41.81.5
Progressive ratio test 1 inactive lever presses0.40.50.90.21.0
Progressive ratio test 2 active lever presses0.20.20.2-0.4-0.4
Progressive ratio test 2 breakpoint0.30.30.3-0.5-0.6
Progressive ratio test 2 inactive lever presses0.10.20.3-0.6-0.0
Incentive Sensitization - Responses3.33.44.3-2.1-1.6
Incentive Sensitization - Breakpoint3.53.64.1-2.0-1.8
Sum of active levers in priming session hrs 5-60.20.20.30.6-0.1
Progressive ratio0.00.10.10.2-0.3
Food seeking constrained by brief footshock0.20.20.3-0.50.4
Seeking ratio, punishment vs. effort0.10.20.3-0.50.3
Retroperitoneal fat weight0.62.02.91.01.7
Reaction time number correct0.30.50.6-0.6-0.8
Reaction time mean minus median0.50.61.01.00.5
Reaction time mean minus median AUC1.11.52.91.70.3
Reaction time num false alarms1.92.64.90.62.2
Reaction time num false alarms AUC1.92.64.50.92.1
Reaction time trials correct on left0.30.50.6-0.6-0.8
Reaction time trials on left0.30.40.5-0.5-0.7
Reaction time mean0.10.10.1-0.40.2
Reaction time mean AUC0.00.00.1-0.3-0.1
Median of all reaction times0.30.40.8-0.9-0.0
Reaction time omissions1.01.42.70.31.7
Reaction time false alarm rate1.82.54.10.92.0
Reaction time premature initiation rate0.30.40.4-0.60.6
Reaction time premature initiations0.30.50.9-0.90.1
Std. dev. reaction times0.30.50.60.80.5
Reaction time trials completed0.30.40.5-0.5-0.7
Reaction time trials AUC0.40.60.7-0.7-0.8
Run reversals in cocaine runway, females0.80.81.3-1.1-0.6
Run reversals in cocaine runway, males0.20.20.40.70.2
Latency to leave start box in cocaine runway0.00.00.0-0.0-0.2
Latency to leave start box in cocaine runway, F0.50.60.70.70.8
Latency to leave start box in cocaine runway, M2.22.12.6-1.2-1.6
Std. dev. time between licks in bursts1.72.02.91.71.1
Total sessions with >9 infusions0.40.40.80.2-0.9
Short access day 1 total inactive lever presses0.20.20.3-0.5-0.4
Short access day 10 total inactive lever presses2.73.04.6-2.2-1.1
Short access day 1 total infusions0.10.10.1-0.3-0.1
Short access day 10 total infusions0.91.01.01.01.0
Short access total infusions0.00.00.00.20.2
Short access day 1 locomotion0.40.40.40.60.6
Short access day 10 total locomotion0.40.50.90.10.9
Short access total locomotion1.31.41.61.31.1
One hour access (0.3 mA shock)2.42.84.3-1.1-2.1
Compulsive drug intake3.03.14.0-2.0-1.5
One hour access (shock baseline)1.01.22.20.4-1.5
Social response proportion0.30.30.5-0.50.7
Social responses1.52.02.41.21.6
Social time0.50.60.7-0.80.8
Soleus weight0.51.62.6-0.8-1.6
Bone: stiffness5.58.710.4-3.2-2.7
Tibialis anterior weight2.68.816.4-1.1-4.0
Time to tail flick, vehicle, before self-admin0.30.30.60.70.1
Time to tail flick, vehicle, after self-admin1.01.01.7-1.3-0.6
Time to tail flick, test, before self-admin1.41.41.51.11.2
Time to tail flick, test, after self-admin3.63.75.2-2.3-1.5
Delta time to tail flick, vehicle, before/after SA1.81.72.9-1.7-0.7
Delta time to tail flick, test, before/after SA6.76.08.4-2.9-1.9
Tibia length1.33.65.8-2.4-1.2
Ambulatory time before self-admin0.60.61.11.1-0.2
Ambulatory time after self-admin1.61.82.7-1.6-0.9
Bone: tissue strength1.41.41.8-1.0-1.3
Total heroin consumption3.84.46.2-2.5-1.6
Bone: trabecular number0.71.01.9-1.4-0.5
Bone: trabecular spacing0.00.00.0-0.2-0.2
Bone: trabecular thickness0.00.00.1-0.10.3
Bone: trabecular tissue density0.00.10.10.30.2
Water consumed over 24 hours0.10.10.1-0.3-0.2
Number of responses in last shaping day2.22.32.71.41.6