Hub : Genes

Itgb7

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Itgb7	0.24	0.11	2.0e-07	0.07	0.06	0.06	0.07	2.4e-08	8.4e-07	1.4e-07	5.6e-08
2	Adipose	alternative polyA	XM_006242383.5	0.04	0.03	4.7e-04	0.04	0.03	0.04	0.04	2.7e-05	2.6e-04	3.1e-05	2.4e-05
3	Adipose	alternative polyA	NM_013171.1	0.04	0.03	5.1e-04	0.04	0.03	0.04	0.04	2.3e-05	2.8e-04	3.8e-05	2.7e-05
4	Brain	gene expression	Itgb7	0.16	0.07	8.8e-13	0.13	0.14	0.14	0.14	3.5e-12	6.5e-13	5.2e-13	3.3e-13

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	2.6	4.4	5.1	2.3	-2.2	2.2	-1.7
Area under the delay curve	0.6	0.7	0.9	0.9	-0.9	0.7	-0.8
BMI with tail	3.3	11.5	13.0	3.5	-3.6	3.5	-2.9
BMI without tail	0.9	2.9	3.4	1.6	-1.7	1.6	-1.8
Body weight	1.0	4.6	5.1	2.1	-2.2	2.2	-2.0
Weight adjusted by age	0.7	1.1	1.3	-1.0	1.1	-1.0	0.9
Bone surface	4.5	8.1	8.8	3.0	-2.9	3.0	-2.5
Bone volume	4.0	7.2	7.9	2.8	-2.8	2.8	-2.3
Breakpoint value in progressive ratio session	2.4	2.9	3.7	1.9	-1.7	1.7	-1.5
Number of licking bursts	0.5	0.8	1.1	-1.0	1.0	-1.0	0.4
Context. condit. distance diff. score	0.2	0.3	0.4	0.6	-0.6	0.6	-0.3
Locomotion velocity, session 1	9.0	9.7	10.9	-3.3	3.2	-3.2	2.7
Locomotion distance, session 1	7.0	8.9	10.0	-3.2	3.1	-3.1	2.5
Locomotion velocity, session 2	3.3	3.8	4.4	-2.1	2.0	-2.0	1.7
Locomotion distance, session 2	4.8	6.7	7.2	-2.7	2.6	-2.6	2.5
Locomotion velocity, session 3	2.9	3.3	3.7	-1.9	1.9	-1.8	1.6
Locomotion distance, session 3	1.9	2.1	2.2	-1.5	1.5	-1.4	1.4
Stereotopy head waving bouts, day 3	1.3	1.5	1.9	1.1	-1.2	1.1	-1.4
Stereotopy head waving duration, day 3	0.4	0.4	0.6	0.6	-0.7	0.6	-0.8
Locomotion velocity, session 7	0.8	0.9	1.0	-1.0	1.0	-1.0	0.9
Locomotion distance, session 7	4.2	5.3	6.2	-2.4	2.5	-2.4	1.9
Stereotopy head waving bouts, day 7	1.3	1.4	2.0	1.1	-1.2	1.1	-1.4
Stereotopy head waving duration, day 7	1.7	2.1	2.7	1.4	-1.4	1.3	-1.6
Locomotion velocity, session 8	0.1	0.1	0.1	-0.3	0.3	-0.3	0.2
Locomotion distance, session 8	2.9	4.2	4.3	-2.1	2.1	-2.0	2.1
Degree of sensitization distance	0.1	0.1	0.1	-0.3	0.4	-0.3	0.2
Degree of sensitization stereotypy	0.9	0.9	1.4	0.9	-0.9	0.8	-1.2
Conditioned locomotion	0.6	0.7	1.4	-0.8	0.6	-0.7	1.2
Cocaine response after cond. corrected	2.0	2.4	2.7	-1.6	1.5	-1.7	1.4
Cocaine response after cond. not corrected	1.3	1.5	1.6	-1.2	1.2	-1.3	1.3
Cocaine response before conditioning	0.1	0.2	0.3	0.5	-0.5	0.5	-0.1
Saline control response	0.1	0.1	0.4	0.0	0.0	0.0	0.6
Bone: connectivity density	0.7	1.1	1.5	1.2	-1.2	1.2	-0.5
Bone: cortical apparent density	2.1	2.9	3.2	-1.7	1.8	-1.8	1.4
Bone: cortical area	2.3	3.6	4.3	2.0	-2.0	2.1	-1.4
Bone: cortical porosity	0.0	0.0	0.1	-0.0	-0.0	0.0	0.4
Bone: cortical porosity	0.1	0.1	0.3	-0.1	0.1	-0.0	0.5
Bone: cortical thickness	0.2	0.3	0.4	0.6	-0.5	0.6	-0.3
Bone: cortical thickness	1.1	1.2	2.5	-0.9	0.9	-0.9	1.6
Bone: cortical tissue density	2.3	3.1	3.5	-1.8	1.9	-1.9	1.5
Condit. Reinf. active minus inactive responses	0.7	0.8	1.1	-0.8	0.8	-0.7	1.1
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.6	-0.4	0.4	-0.4	0.8
Condit. Reinf. active responses	1.7	2.1	3.1	-1.4	1.4	-1.3	1.8
Condit. Reinf. inactive responses	2.2	2.7	3.2	-1.6	1.5	-1.7	1.8
Incentive salience index mean	0.3	0.3	0.6	-0.5	0.5	-0.4	0.8
Condit. Reinf. lever presses	0.0	0.1	0.1	-0.2	0.3	-0.2	0.2
Condit. Reinf. active minus inactive responses	0.2	0.3	0.4	0.6	-0.5	0.5	-0.6
Condit. Reinf. active-inactive response ratio	0.2	0.3	0.3	0.5	-0.5	0.6	-0.6
Condit. Reinf. active responses	0.1	0.2	0.4	0.4	-0.3	0.3	-0.6
Condit. Reinf. inactive responses	0.2	0.3	0.4	-0.6	0.6	-0.6	0.3
Condit. Reinf. lever presses	0.1	0.1	0.4	-0.2	0.2	-0.3	0.6
Condit. Reinf. lever reinforcers received	0.0	0.0	0.0	0.0	0.0	-0.1	-0.1
Conditioned reinforcement - actives	0.7	1.1	1.5	-1.2	1.2	-1.2	0.5
Conditioned reinforcement - inactives	0.8	1.2	1.9	-1.0	0.9	-0.9	1.4
Conditioned locomotion	0.1	0.1	0.2	-0.4	0.4	-0.4	-0.1
Patch foraging indifference point 0 sec	2.1	3.9	4.5	-2.1	2.1	-2.1	1.7
Patch foraging indifference point AUC	1.8	2.6	3.0	-1.7	1.7	-1.7	1.2
Delay disc. indifference point, 0s delay	0.0	0.0	0.0	-0.2	-0.0	-0.2	-0.0
Delay disc. indifference point, 16s delay	0.6	0.6	0.8	0.9	-0.9	0.9	-0.4
Delay disc. indifference point, 2s delay	1.3	1.4	3.2	1.0	-0.9	0.8	-1.8
Delay disc. indifference point, 24s delay	0.2	0.3	0.5	0.4	-0.3	0.7	-0.5
Delay disc. indifference point, 4s delay	1.1	1.2	1.4	1.1	-1.2	1.0	-1.0
Delay disc. indifference point, 8s delay	0.3	0.3	0.5	0.7	-0.6	0.5	-0.5
Indifference point function ln k	3.0	5.2	5.7	2.4	-2.4	2.4	-2.0
Indifference point function log k	3.0	5.2	5.7	2.4	-2.4	2.4	-2.0
Patch foraging total patch changes 0 sec	2.5	4.7	5.3	-2.3	2.2	-2.3	1.8
Patch foraging total patch changes 12 sec	4.7	6.1	6.8	-2.6	2.5	-2.6	2.2
Patch foraging total patch changes 18 sec	5.3	8.0	8.9	-3.0	2.9	-3.0	2.4
Patch foraging total patch changes 24 sec	1.6	2.8	3.4	-1.8	1.8	-1.8	1.1
Patch foraging total patch changes 6 sec	5.3	8.0	10.4	-3.2	3.1	-3.1	1.5
Patch foraging time to switch 0 sec	0.1	0.2	0.3	-0.5	0.5	-0.5	0.1
Patch foraging water rate 0 sec	0.1	0.3	0.4	0.5	-0.7	0.6	-0.2
Patch foraging water rate 12 sec	0.1	0.3	0.4	0.5	-0.6	0.6	-0.1
Patch foraging water rate 18 sec	0.0	0.0	0.0	0.0	-0.0	0.0	0.1
Patch foraging water rate 24 sec	0.4	0.6	0.7	0.7	-0.8	0.8	-0.7
Patch foraging water rate 6 sec	2.5	3.7	4.7	2.1	-2.2	2.1	-1.0
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.1	0.2	-0.3	0.3	0.3
Distance traveled before self-admin	0.1	0.1	0.2	0.3	-0.2	0.5	-0.3
Distance traveled after self-admin	0.8	0.9	1.4	1.1	-1.0	1.2	-0.2
Extensor digitorum longus weight	4.9	19.3	30.1	4.0	-4.0	4.0	-5.5
Bone: elastic displacement	1.6	1.8	2.2	-1.5	1.4	-1.4	1.1
Bone: elastic work	0.4	0.5	0.7	-0.8	0.7	-0.7	0.5
Bone: endosteal estimation	4.2	9.1	10.1	3.0	-3.1	3.2	-2.7
Bone: endosteal perimeter	4.2	8.9	10.2	3.1	-3.1	3.2	-2.5
Epididymis fat weight	0.1	0.4	0.7	0.4	-0.6	0.7	0.8
Delta time in closed arm before/after self-admin	1.2	1.1	1.8	1.3	-1.0	1.1	-0.7
Delta time in open arm before/after self-admin	1.7	1.6	2.4	-1.3	1.3	-1.0	1.5
Diff in mean of infusions in LGA sessions	0.2	0.2	0.4	0.1	-0.6	0.6	-0.2
Delay discount exponential model param	1.0	1.1	1.3	-1.1	1.0	-0.9	1.1
Extinction: sum of active levers before priming	3.1	3.4	4.2	1.8	-1.9	1.7	-2.0
Active lever presses in extinction session 6	0.8	0.8	1.0	1.0	-1.0	0.8	-0.7
Bone: final force	4.0	6.4	7.1	2.6	-2.6	2.7	-2.2
Bone: final moment	4.9	7.8	8.4	2.8	-2.9	2.9	-2.6
Food consumed during 24 hour testing period	0.4	0.6	0.8	0.8	-0.9	0.9	-0.2
Glucose	0.7	1.1	1.3	-1.1	1.1	-1.1	0.8
Heart weight	1.3	1.9	2.7	1.6	-1.6	1.6	-0.2
Delay discount hyperbolic model param	1.0	1.1	1.3	-1.1	1.0	-0.9	1.2
Intermittent access intake day 1-15 change	0.0	0.1	0.1	0.4	-0.1	0.3	-0.1
Intermittent access intake escalation	0.0	0.0	0.1	0.3	-0.1	0.2	-0.1
Intermittent access intake escalation 2	0.0	0.0	0.1	0.3	-0.1	0.2	0.1
Intermitt. access day 1 inactive lever presses	0.1	0.5	0.6	0.8	-0.7	0.8	-0.5
Intermitt. access day 15 inactive lever presses	0.1	0.2	0.4	0.4	-0.4	0.7	-0.1
Intermitt. access escalation Index	0.2	0.3	0.9	-0.2	0.1	-0.3	-0.9
Intermittent access day 1 total infusions	0.6	0.9	1.0	-1.0	0.9	-0.9	1.0
Intermittent access day 15 total infusions	1.3	1.9	2.4	-1.5	1.5	-1.4	0.9
Intermittent access terminal intake (last 3 days)	0.9	1.1	1.5	-1.1	1.2	-1.1	0.7
Intermittent access total infusions	0.8	1.0	1.3	-1.1	1.1	-1.1	0.6
Intermittent access day 1 locomotion	0.3	0.3	0.5	-0.7	0.6	-0.6	0.3
Intermittent access day 15 total locomotion	0.2	0.4	0.5	0.7	-0.7	0.7	-0.2
Intermittent access total locomotion	0.0	0.0	0.0	-0.0	0.1	-0.1	-0.0
Intermittent access standard deviation	0.4	0.8	1.3	-0.6	0.9	-0.9	1.1
Left kidney weight	0.1	0.3	0.5	0.5	-0.7	0.7	0.1
Right kidney weight	0.3	1.5	1.8	1.3	-1.3	1.3	-0.9
Cocaine induced anxiety	0.8	1.1	2.4	0.9	-0.7	0.7	-1.6
Post-drug Anxiety	2.6	2.7	3.4	1.8	-1.7	1.6	-1.5
Baseline Anxiety	0.4	0.4	0.6	0.6	-0.7	0.5	0.8
Tail length	0.5	2.0	2.3	-1.5	1.5	-1.5	1.1
Length with tail	0.0	0.1	0.1	-0.4	0.3	-0.4	0.3
Length without tail	0.6	2.0	2.3	1.4	-1.5	1.5	-1.1
Times rat made contact with spout	0.5	0.6	0.7	0.8	-0.8	0.9	-0.6
Lifetime Intake	0.5	0.6	0.8	-0.8	0.8	-0.9	0.5
Liver weight, left	7.2	12.0	12.7	3.5	-3.6	3.5	-3.2
Liver weight, right	0.7	1.3	1.7	1.3	-1.1	1.1	-0.9
Locomotor activity	0.1	0.1	0.2	-0.3	0.4	-0.4	0.0
Locomotor testing distance	0.4	0.7	1.0	-0.8	1.0	-1.0	0.2
Locomotor testing rearing	0.2	0.3	0.6	-0.4	0.7	-0.8	-0.0
Locomotion in novel chamber	4.2	5.4	8.4	2.2	-2.0	2.1	-2.9
Locomotion in novel chamber post-restriction	0.0	0.1	0.3	0.1	0.1	0.1	-0.5
Fecal boli incidents, locomotor time 1	1.7	2.4	2.8	-1.3	1.7	-1.6	1.6
Change in fecal boli incidents, locomotor task	0.4	0.4	0.5	0.4	-0.6	0.6	-0.7
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	0.0	-0.1	0.0	0.5
Bouts of movement, locomotor time 1	1.4	1.6	2.4	-1.2	1.1	-1.1	1.5
Total resting periods, locomotor time 1	2.5	2.8	3.7	-1.7	1.5	-1.5	1.9
Rest time, locomotor task time 1	1.2	1.5	1.9	-1.4	1.3	-1.1	0.9
Distance moved, locomotor task time 1	0.2	0.3	0.5	0.5	-0.6	0.5	-0.7
Vertical activity count, locomotor time 1	0.3	0.7	0.8	0.9	-0.8	0.8	-0.7
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.1	-0.2	-0.0	-0.0	0.1
Bouts of movement, locomotor time 2	0.6	1.0	1.6	1.0	-0.8	0.9	-1.3
Total resting periods, locomotor time 2	0.5	0.9	1.4	0.9	-0.8	0.9	-1.2
Rest time, locomotor task time 2	1.2	1.5	1.8	-1.2	1.4	-1.3	1.1
Distance moved, locomotor task time 2	0.1	0.1	0.1	0.1	-0.4	0.4	-0.1
Vertical activity count, locomotor time 2	0.1	0.2	0.5	0.3	-0.3	0.4	-0.7
Light reinforcement 1	1.6	4.0	4.2	-2.0	1.9	-2.0	2.0
Light reinforcement 2	2.6	4.1	4.4	-2.1	2.1	-2.1	1.8
Bone: marrow area	4.1	8.9	9.8	3.0	-3.1	3.1	-2.7
Bone: maximum diameter	1.6	3.0	3.4	1.8	-1.8	1.9	-1.4
Bone: maximum force	2.7	4.9	5.3	2.1	-2.2	2.3	-2.2
Bone: maximum moment	3.4	6.0	6.3	2.4	-2.5	2.5	-2.5
Mean time between licks in bursts	0.9	2.2	3.0	-1.7	1.7	-1.7	0.5
Mean num. licks in bursts	1.0	1.6	2.0	1.4	-1.4	1.4	-0.7
Cd content in liver	0.2	0.2	0.3	-0.5	0.5	-0.5	0.3
Co content in liver	0.2	0.2	0.5	0.3	-0.3	0.3	-0.7
Cu content in liver	9.7	11.5	12.4	3.5	-3.5	3.5	-3.0
Fe content in liver	0.1	0.1	0.2	-0.2	0.2	-0.2	-0.4
K content in liver	0.5	0.5	0.8	0.6	-0.6	0.6	-0.9
Mg content in liver	0.4	0.4	0.7	0.6	-0.6	0.6	-0.8
Mn content in liver	0.4	0.5	0.6	-0.8	0.8	-0.8	0.2
Na content in liver	1.5	1.6	1.9	1.3	-1.2	1.2	-1.4
Rb content in liver	1.3	1.5	1.7	1.2	-1.2	1.1	-1.3
Se content in liver	0.4	0.4	0.5	-0.7	0.6	-0.6	0.7
Sr content in liver	0.0	0.0	0.0	-0.1	0.1	-0.1	0.1
Zn content in liver	0.2	0.2	0.9	-0.1	0.1	-0.1	0.9
Bone: minimum diameter	3.9	7.0	8.3	2.7	-2.8	2.9	-2.1
Time in familiar zone, hab. session 1	0.0	0.0	0.0	0.0	-0.0	0.0	0.2
Time in novel zone, hab. session 1	0.0	0.0	0.1	0.1	-0.1	0.1	-0.3
Total zone transitions, hab. session 1	1.3	1.9	2.1	-1.4	1.5	-1.3	1.3
Total locomotion distance, hab. session 1	2.3	3.3	4.7	-1.7	1.7	-1.6	2.2
Locomotion velocity, hab. session 1	1.9	2.7	3.2	-1.6	1.6	-1.5	1.8
Time in familiar zone, hab. session 2	1.4	1.5	2.2	1.2	-1.1	1.1	-1.5
Time in novel zone, hab. session 2	0.5	0.5	0.5	-0.7	0.7	-0.7	0.7
Total zone transitions, hab. session 2	1.5	2.0	2.1	-1.4	1.4	-1.3	1.5
Total locomotion distance, hab. session 2	1.8	2.3	4.0	-1.4	1.3	-1.2	2.0
Locomotion velocity, hab. session 2	1.6	2.1	3.8	-1.3	1.2	-1.2	2.0
Novel to familiar place preference ratio	0.2	0.2	0.3	0.5	-0.5	0.5	-0.1
Novelty place preference	0.1	0.1	0.1	0.3	-0.3	0.4	-0.1
Time in novel zone, NPP test	0.1	0.2	0.2	0.4	-0.4	0.5	-0.2
Total zone transitions, NPP test	6.0	8.7	9.1	-3.0	3.0	-2.9	2.9
Total locomotion distance, NPP test	6.5	8.8	11.1	-2.9	2.8	-2.8	3.3
Locomotion velocity, NPP test	6.3	8.9	11.5	-2.9	2.8	-2.7	3.4
Intraocular pressure	0.4	0.6	0.9	-0.8	1.0	-0.9	0.4
Delta distance traveled before/after self-admin	0.5	0.6	0.6	0.8	-0.8	0.8	0.7
Delta ambulatory time before/after self-admin	0.9	1.2	1.7	1.3	-1.2	1.2	0.4
Parametrial fat weight	0.3	0.7	0.9	-0.8	0.7	-0.8	0.9
Pavlov. Cond. lever latency	0.2	0.2	0.4	-0.4	0.3	-0.4	0.6
Pavlov. Cond. magazine entry latency	0.6	0.7	2.1	0.5	-0.4	0.5	-1.5
Pavlov. Cond. change in total contacts	1.6	1.7	2.5	1.2	-1.2	1.2	-1.6
Pavlov. Cond. index score	1.2	1.5	3.1	1.0	-0.9	1.0	-1.8
Pavlov. Cond. latency score	1.3	1.6	2.9	1.1	-1.0	1.1	-1.7
Pavlov. Cond. lever contacts	0.2	0.3	0.8	0.3	-0.2	0.3	-0.9
Pavlov. Cond. magazine entry number	0.3	0.4	1.3	-0.4	0.3	-0.3	1.1
Pavlov. Cond. intertrial magazine entries	2.4	2.9	3.7	-1.6	1.6	-1.6	1.9
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.3	3.0	0.9	-0.8	0.9	-1.7
Pavlov. Cond. response bias	0.2	0.2	0.9	0.2	-0.1	0.1	-0.9
Pavlov. Cond. lever latency	0.9	1.2	2.3	1.0	-0.9	0.9	-1.5
Pavlov. Cond. magazine entry latency	2.6	3.2	3.9	-1.7	1.7	-1.7	2.0
Pavlov. Cond. change in total contacts	0.0	0.1	0.1	0.3	-0.3	0.2	-0.0
Pavlov. Cond. index score	1.8	2.5	3.6	-1.5	1.4	-1.5	1.9
Pavlov. Cond. latency score	2.0	2.7	3.8	-1.5	1.5	-1.6	1.9
Pavlov. Cond. lever contacts	1.1	1.6	3.1	-1.1	1.0	-1.0	1.8
Pavlov. Cond. magazine entry number	0.9	1.1	1.8	0.9	-0.9	1.0	-1.3
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.0	-0.0	0.1	0.0	0.1
Pavlov. Cond. lever-magazine prob. diff.	1.3	1.8	2.7	-1.2	1.2	-1.3	1.6
Pavlov. Cond. response bias	0.7	1.0	1.9	-0.9	0.8	-0.9	1.4
Time in closed arm before self-admin	0.1	0.2	0.3	-0.5	0.4	-0.4	0.1
Time in closed arm after self-admin	0.3	0.4	0.6	0.5	-0.5	0.5	-0.8
Time in open arm before self-admin	0.8	0.9	1.8	0.9	-0.7	0.7	-1.3
Time in open arm after self-admin	0.1	0.1	0.2	-0.1	0.2	0.0	0.5
Bone: periosteal estimation	5.5	11.6	13.1	3.5	-3.6	3.6	-2.8
Bone: periosteal perimeter	4.7	8.2	9.2	2.9	-3.0	3.0	-2.5
Bone: post-yield work	1.5	2.2	2.3	1.4	-1.5	1.5	-1.5
Progressive ratio test 1 active lever presses	4.0	4.9	5.9	-2.3	2.4	-2.4	1.6
Progressive ratio test 1 breakpoint	3.8	4.7	5.5	-2.3	2.3	-2.3	1.6
Progressive ratio test 1 inactive lever presses	0.3	0.4	0.4	-0.7	0.6	-0.5	0.6
Progressive ratio test 2 active lever presses	0.0	0.1	0.1	0.3	-0.1	0.2	-0.3
Progressive ratio test 2 breakpoint	0.1	0.1	0.1	0.3	-0.1	0.2	-0.3
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.4	0.6	-0.4	0.6	-0.3
Incentive Sensitization - Responses	1.5	2.1	2.5	1.6	-1.4	1.5	-1.3
Incentive Sensitization - Breakpoint	1.8	2.4	2.7	1.7	-1.5	1.6	-1.4
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.1	-0.1	0.1	-0.3	0.1
Progressive ratio	0.0	0.1	0.1	-0.4	0.3	-0.1	0.1
Food seeking constrained by brief footshock	0.1	0.1	0.5	0.1	-0.0	-0.2	0.7
Seeking ratio, punishment vs. effort	0.1	0.1	0.2	0.4	-0.4	0.0	0.3
Retroperitoneal fat weight	0.8	3.5	4.7	-1.8	1.7	-1.8	2.2
Reaction time number correct	0.1	0.1	0.4	0.0	-0.2	0.3	-0.6
Reaction time mean minus median	0.2	0.4	0.4	-0.6	0.6	-0.6	0.6
Reaction time mean minus median AUC	0.1	0.4	0.5	-0.7	0.7	-0.6	0.5
Reaction time num false alarms	3.6	5.0	6.3	-2.0	2.2	-2.2	2.5
Reaction time num false alarms AUC	3.6	5.6	6.7	-2.2	2.4	-2.4	2.6
Reaction time trials correct on left	0.1	0.1	0.4	0.0	-0.2	0.3	-0.6
Reaction time trials on left	0.0	0.1	0.3	-0.0	-0.2	0.2	-0.5
Reaction time mean	0.5	0.7	1.2	1.1	-1.0	0.9	-0.2
Reaction time mean AUC	0.6	1.0	1.4	1.2	-1.1	1.0	-0.5
Median of all reaction times	1.2	1.7	2.6	1.6	-1.4	1.4	-0.5
Reaction time omissions	0.7	1.0	3.4	-0.4	0.4	-0.3	1.8
Reaction time false alarm rate	2.6	3.7	5.1	-1.6	1.9	-1.9	2.3
Reaction time premature initiation rate	0.1	0.1	0.3	0.3	-0.2	0.1	0.6
Reaction time premature initiations	0.1	0.1	0.2	0.4	-0.4	0.3	0.1
Std. dev. reaction times	0.0	0.1	0.2	-0.1	0.2	-0.2	0.5
Reaction time trials completed	0.0	0.1	0.3	-0.0	-0.2	0.2	-0.5
Reaction time trials AUC	0.1	0.2	0.5	0.1	-0.3	0.3	-0.7
Run reversals in cocaine runway, females	0.3	0.3	0.6	0.7	-0.8	0.5	-0.2
Run reversals in cocaine runway, males	1.0	1.0	1.9	-1.4	1.1	-0.9	0.2
Latency to leave start box in cocaine runway	0.1	0.1	0.2	0.4	-0.3	0.3	-0.4
Latency to leave start box in cocaine runway, F	0.3	0.3	0.4	-0.5	0.6	-0.6	0.4
Latency to leave start box in cocaine runway, M	2.1	2.0	2.4	1.5	-1.4	1.4	-1.2
Std. dev. time between licks in bursts	1.5	2.1	2.6	-1.6	1.6	-1.6	0.9
Total sessions with >9 infusions	0.2	0.2	0.3	-0.2	0.4	-0.6	0.5
Short access day 1 total inactive lever presses	0.0	0.0	0.0	-0.1	0.2	-0.2	-0.0
Short access day 10 total inactive lever presses	0.6	1.5	2.2	1.5	-1.3	1.3	-0.6
Short access day 1 total infusions	0.1	0.2	0.3	0.6	-0.4	0.3	0.0
Short access day 10 total infusions	0.7	0.9	1.1	-1.0	1.0	-1.0	0.8
Short access total infusions	0.1	0.2	0.3	-0.4	0.5	-0.6	0.3
Short access day 1 locomotion	0.0	0.0	0.1	0.3	-0.2	0.0	-0.1
Short access day 10 total locomotion	0.1	0.1	0.2	0.5	-0.4	0.2	0.0
Short access total locomotion	0.2	0.3	0.5	-0.4	0.5	-0.7	0.4
One hour access (0.3 mA shock)	1.8	2.1	2.5	1.4	-1.4	1.4	-1.6
Compulsive drug intake	2.2	2.6	3.2	1.6	-1.8	1.8	-1.2
One hour access (shock baseline)	0.2	0.3	0.9	0.4	-0.4	0.4	-0.9
Social response proportion	0.5	0.6	1.4	-0.4	0.7	-0.6	1.2
Social responses	1.8	2.4	2.6	-1.4	1.6	-1.6	1.6
Social time	0.4	0.5	1.0	-0.5	0.7	-0.5	1.0
Soleus weight	0.5	1.5	2.4	1.1	-1.1	1.1	-1.5
Bone: stiffness	4.7	7.7	8.4	2.8	-2.9	2.9	-2.5
Tibialis anterior weight	3.2	10.8	18.5	3.0	-2.8	2.8	-4.3
Time to tail flick, vehicle, before self-admin	0.0	0.0	0.0	0.2	-0.0	-0.1	-0.1
Time to tail flick, vehicle, after self-admin	0.5	0.6	0.8	0.7	-0.8	0.9	-0.7
Time to tail flick, test, before self-admin	1.5	1.6	1.8	-1.3	1.3	-1.2	1.1
Time to tail flick, test, after self-admin	1.8	1.9	2.5	1.6	-1.4	1.4	-1.0
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	0.9	0.6	-0.9	1.0	-0.6
Delta time to tail flick, test, before/after SA	3.1	3.2	4.2	2.0	-2.0	1.8	-1.1
Tibia length	1.3	3.7	4.9	2.2	-2.0	2.1	-1.3
Ambulatory time before self-admin	0.0	0.0	0.0	-0.2	0.1	0.1	-0.1
Ambulatory time after self-admin	1.6	1.8	2.5	1.6	-1.5	1.6	-0.5
Bone: tissue strength	1.1	1.2	2.1	0.8	-0.9	1.0	-1.4
Total heroin consumption	3.4	4.0	5.0	2.2	-2.0	2.0	-1.8
Bone: trabecular number	0.8	1.3	1.8	1.3	-1.3	1.2	-0.6
Bone: trabecular spacing	0.0	0.0	0.0	-0.0	0.1	-0.1	-0.2
Bone: trabecular thickness	0.0	0.0	0.1	-0.1	-0.0	0.0	0.3
Bone: trabecular tissue density	0.4	0.6	0.7	-0.6	0.8	-0.8	0.7
Water consumed over 24 hours	0.0	0.0	0.2	0.1	-0.1	0.1	-0.4
Number of responses in last shaping day	2.3	2.5	2.9	-1.4	1.6	-1.6	1.7