Hub : Genes

Itgae

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain isoform ratio NM_031768.3 0.07 0.04 7.4e-07 0.04 0.06 0.06 0.05 2.5e-04 3.0e-06 2.2e-06 8.2e-06
2 PL isoform ratio NM_031768.3 0.07 0.04 1.2e-09 0.08 0.08 0.08 0.08 2.5e-09 2.0e-09 2.9e-09 1.7e-09
3 IC isoform ratio NM_031768.3 0.11 0.07 6.0e-05 0.06 0.03 0.08 0.01 2.2e-03 1.9e-02 4.4e-04 7.8e-02
4 Liver intron excision ratio chr10_58251328_58261109 0.05 0.03 3.0e-05 0.02 0.02 0.02 0.02 4.8e-03 1.0e-03 1.5e-03 2.6e-03
5 Liver gene expression Itgae 0.53 0.11 0.0e+00 0.36 0.36 0.36 0.36 4.5e-42 1.6e-41 5.0e-42 3.9e-42
6 Liver isoform ratio NM_031768.3 0.29 0.13 0.0e+00 0.21 0.2 0.2 0.2 8.3e-23 2.0e-21 4.0e-22 2.8e-22
7 Liver isoform ratio XM_039086945.1 0.29 0.12 0.0e+00 0.21 0.2 0.2 0.21 4.8e-23 1.3e-21 2.6e-22 1.7e-22
8 NAcc gene expression Itgae 0.02 0.02 1.6e-03 0.01 0.01 0.01 0.01 1.0e-02 2.8e-03 1.5e-02 9.2e-03
9 pVTA isoform ratio NM_031768.3 0.13 0.07 3.9e-14 0.17 0.16 0.16 0.16 5.7e-14 3.5e-13 8.4e-13 5.0e-13
10 Brain gene expression Itgae 0.05 0.04 9.7e-05 0.05 0.05 0.05 0.05 1.4e-05 3.4e-05 3.9e-05 3.0e-05
11 NAcc isoform ratio NM_031768.3 0.02 0.02 2.2e-04 0.03 0.02 0.02 0.03 5.2e-05 3.8e-04 1.1e-04 9.4e-05
12 Liver mRNA stability Itgae 0.08 0.04 7.4e-10 0.06 0.06 0.06 0.07 5.9e-07 9.5e-08 2.0e-07 5.4e-08
13 Adipose gene expression Itgae 0.08 0.06 2.3e-07 0.04 0.04 0.03 0.04 2.4e-05 1.4e-05 1.0e-04 6.0e-05
14 NAcc intron excision ratio chr10_58251328_58261109 0.04 0.03 9.9e-03 0.01 0.01 0.01 0.01 1.4e-02 2.9e-02 2.7e-03 3.7e-03
15 NAcc intron excision ratio chr10_58249594_58251233 0.05 0.04 5.7e-04 0.02 0.02 0.02 0.02 4.9e-04 4.1e-04 4.0e-04 7.3e-04
16 Adipose intron excision ratio chr10_58251328_58261109 0.35 0.15 0.0e+00 0.22 0.23 0.21 0.22 3.4e-24 3.4e-25 2.6e-23 1.2e-23

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
Bone: apparent density0.91.64.7-0.3-1.1-1.0-0.51.2-1.11.1-0.6-1.1-1.1-1.10.9-1.61.9-2.21.8
Area under the delay curve0.20.20.40.40.60.50.4-0.50.5-0.50.40.50.40.5-0.30.6-0.50.6-0.4
BMI with tail0.20.73.71.00.70.70.7-0.40.4-0.40.50.50.30.4-0.80.01.9-1.60.8
BMI without tail0.61.86.30.0-1.0-0.9-0.31.3-1.21.2-0.2-1.0-0.9-0.91.1-1.81.7-2.32.5
Body weight0.83.313.90.2-1.6-1.3-0.21.6-1.21.20.0-1.1-1.2-1.11.7-2.42.4-3.33.7
Weight adjusted by age1.92.94.31.92.01.91.8-1.91.8-1.81.51.81.51.6-2.11.42.0-1.0-0.1
Bone surface0.40.74.01.00.40.40.7-0.20.2-0.20.50.20.30.3-0.6-0.22.0-1.81.2
Bone volume0.50.94.11.10.40.50.9-0.30.4-0.40.80.40.50.5-0.5-0.12.0-1.91.4
Breakpoint value in progressive ratio session0.70.84.01.00.40.50.8-0.30.3-0.30.70.40.30.3-0.7-0.32.0-1.91.5
Number of licking bursts0.10.20.6-0.7-0.5-0.3-0.50.5-0.40.4-0.5-0.2-0.4-0.40.7-0.1-0.80.7-0.4
Context. condit. distance diff. score0.81.04.91.20.90.80.9-0.50.5-0.50.70.50.50.5-1.00.12.2-1.81.0
Locomotion velocity, session 11.01.15.11.10.10.30.80.10.2-0.20.90.20.20.20.2-0.62.0-2.32.1
Locomotion distance, session 10.50.71.51.10.60.81.1-0.70.9-0.91.21.00.91.0-0.20.50.5-0.50.6
Locomotion velocity, session 20.91.12.9-0.9-1.4-1.3-0.91.3-1.01.0-0.6-1.0-1.0-1.01.7-1.2-0.6-0.20.9
Locomotion distance, session 20.10.20.80.2-0.3-0.20.00.3-0.20.20.1-0.2-0.2-0.10.5-0.50.7-0.90.8
Locomotion velocity, session 31.82.07.3-1.8-1.5-1.5-1.41.1-1.01.0-1.2-1.0-1.0-1.01.7-0.6-2.72.0-0.9
Locomotion distance, session 30.10.10.3-0.5-0.2-0.3-0.50.3-0.40.4-0.6-0.3-0.5-0.40.0-0.2-0.10.1-0.3
Stereotopy head waving bouts, day 30.20.20.8-0.4-0.7-0.6-0.30.4-0.20.2-0.1-0.2-0.3-0.30.9-0.4-0.60.20.3
Stereotopy head waving duration, day 30.81.02.20.40.50.70.8-0.91.1-1.11.01.11.11.1-0.01.2-1.51.4-0.9
Locomotion velocity, session 70.10.10.40.30.30.40.3-0.20.3-0.30.20.30.20.3-0.20.30.7-0.3-0.2
Locomotion distance, session 70.10.21.5-0.00.30.2-0.10.1-0.20.2-0.4-0.2-0.2-0.2-0.6-0.01.2-0.7-0.2
Stereotopy head waving bouts, day 70.60.61.81.10.30.51.1-0.50.8-0.81.30.80.70.70.20.10.5-0.91.3
Stereotopy head waving duration, day 70.40.51.30.90.20.40.9-0.40.7-0.71.10.70.60.60.20.10.4-0.81.1
Locomotion velocity, session 80.60.71.31.10.80.81.0-0.80.8-0.81.00.80.80.9-0.70.50.9-0.80.6
Locomotion distance, session 80.71.05.01.10.40.30.8-0.00.2-0.20.70.20.20.3-0.3-0.52.2-2.21.8
Degree of sensitization distance0.50.51.50.90.60.70.8-0.50.6-0.60.70.60.60.6-0.50.41.2-0.90.4
Degree of sensitization stereotypy0.40.42.30.7-0.10.00.60.00.2-0.20.80.20.10.10.5-0.40.8-1.21.5
Conditioned locomotion0.40.41.4-0.8-0.3-0.3-0.70.3-0.40.4-0.8-0.3-0.6-0.50.20.1-1.21.2-1.1
Cocaine response after cond. corrected0.91.01.4-0.9-1.1-1.1-1.01.1-1.21.2-1.1-1.2-1.2-1.21.0-1.20.4-0.60.5
Cocaine response after cond. not corrected0.50.60.9-0.5-0.7-0.8-0.70.8-0.80.8-0.7-0.8-0.9-0.90.5-1.00.7-0.80.6
Cocaine response before conditioning0.60.71.21.10.90.71.0-0.80.9-0.91.00.90.80.8-1.00.50.9-0.70.5
Saline control response0.81.01.61.31.11.01.2-1.01.1-1.11.31.20.91.0-0.90.80.8-0.60.4
Bone: connectivity density0.81.26.50.4-0.4-0.30.00.6-0.60.6-0.2-0.5-0.6-0.60.1-1.12.6-2.51.8
Bone: cortical apparent density0.50.72.0-1.2-0.3-0.4-1.10.6-0.90.9-1.4-0.9-0.8-0.80.1-0.1-0.71.0-1.3
Bone: cortical area0.20.42.2-0.10.10.00.2-0.40.5-0.50.40.40.50.5-0.10.6-1.51.2-0.6
Bone: cortical porosity2.62.83.8-1.6-1.9-1.9-1.71.9-1.91.9-1.5-1.9-1.9-1.91.7-1.9-0.5-0.30.9
Bone: cortical porosity2.02.13.0-1.5-1.7-1.7-1.61.7-1.61.6-1.4-1.6-1.6-1.61.6-1.6-0.80.00.6
Bone: cortical thickness1.93.29.0-2.3-2.0-2.0-1.91.5-1.41.4-1.6-1.5-1.4-1.42.0-1.0-3.02.1-0.8
Bone: cortical thickness4.45.17.6-2.7-2.7-2.8-2.52.4-2.32.3-2.2-2.3-2.3-2.32.5-2.1-2.21.00.2
Bone: cortical tissue density0.50.71.8-1.1-0.3-0.4-1.10.6-0.90.9-1.3-0.9-0.8-0.80.1-0.2-0.50.8-1.1
Condit. Reinf. active minus inactive responses1.21.42.1-1.2-1.2-1.3-1.31.3-1.41.4-1.3-1.4-1.4-1.41.0-1.30.0-0.30.4
Condit. Reinf. active-inactive response ratio0.90.91.4-1.0-1.1-1.2-1.01.0-1.01.0-0.9-1.1-1.1-1.11.1-1.0-0.40.00.3
Condit. Reinf. active responses0.91.11.8-0.9-0.9-0.9-1.11.1-1.31.3-1.3-1.3-1.3-1.30.7-1.10.6-0.70.3
Condit. Reinf. inactive responses0.10.10.80.10.40.4-0.1-0.1-0.20.2-0.4-0.1-0.2-0.1-0.50.10.9-0.4-0.4
Incentive salience index mean2.02.43.5-1.4-1.6-1.7-1.61.7-1.81.8-1.6-1.9-1.8-1.81.5-1.7-0.1-0.50.8
Condit. Reinf. lever presses2.63.75.6-1.4-1.9-2.0-1.82.1-2.22.2-1.8-2.3-2.2-2.21.9-2.40.4-1.21.5
Condit. Reinf. active minus inactive responses0.81.11.8-1.0-0.9-1.0-1.21.1-1.21.2-1.3-1.3-1.3-1.30.7-1.20.3-0.50.4
Condit. Reinf. active-inactive response ratio1.21.42.0-1.3-1.3-1.3-1.41.2-1.31.3-1.3-1.3-1.4-1.41.2-1.3-0.4-0.00.3
Condit. Reinf. active responses0.30.40.8-0.5-0.2-0.4-0.70.6-0.80.8-0.9-0.9-0.9-0.8-0.1-0.70.5-0.50.2
Condit. Reinf. inactive responses0.50.62.30.71.31.10.6-0.70.6-0.60.30.50.60.6-1.50.80.7-0.1-0.5
Condit. Reinf. lever presses0.20.31.4-0.30.40.2-0.4-0.2-0.10.1-0.5-0.1-0.1-0.1-0.50.4-0.91.1-1.2
Condit. Reinf. lever reinforcers received0.20.30.8-0.40.0-0.1-0.60.4-0.70.7-0.9-0.7-0.8-0.7-0.4-0.50.6-0.4-0.1
Conditioned reinforcement - actives0.50.94.11.11.21.00.8-0.70.5-0.50.50.50.50.5-1.20.42.0-1.40.4
Conditioned reinforcement - inactives3.34.98.22.92.42.52.6-2.42.4-2.42.42.12.22.2-2.11.92.2-1.40.3
Conditioned locomotion2.73.56.11.72.52.31.8-2.22.1-2.11.72.11.91.9-2.02.10.20.7-1.0
Patch foraging indifference point 0 sec1.12.13.0-1.5-1.5-1.6-1.71.6-1.61.6-1.5-1.7-1.7-1.61.2-1.5-0.7-0.00.4
Patch foraging indifference point AUC1.72.54.01.61.41.51.7-1.71.8-1.81.81.92.02.0-1.41.8-0.20.4-0.7
Delay disc. indifference point, 0s delay1.71.83.21.81.41.51.6-1.31.4-1.41.61.41.51.5-1.01.01.1-0.90.4
Delay disc. indifference point, 16s delay0.80.91.50.91.21.20.9-1.11.0-1.00.71.00.90.9-1.11.20.30.3-0.8
Delay disc. indifference point, 2s delay0.30.31.6-0.6-0.5-0.6-0.40.4-0.30.3-0.2-0.3-0.2-0.20.7-0.1-1.30.9-0.2
Delay disc. indifference point, 24s delay0.40.40.7-0.8-0.5-0.5-0.80.6-0.70.7-0.8-0.7-0.8-0.70.5-0.3-0.80.7-0.4
Delay disc. indifference point, 4s delay0.30.40.70.70.70.60.7-0.60.7-0.70.80.70.70.7-0.50.5-0.10.10.2
Delay disc. indifference point, 8s delay0.00.00.10.10.30.20.1-0.10.1-0.10.20.10.00.10.20.2-0.40.3-0.1
Indifference point function ln k5.19.013.3-3.3-2.9-3.1-3.53.3-3.53.5-3.5-3.6-3.6-3.62.5-3.1-0.80.10.5
Indifference point function log k5.19.013.3-3.3-2.9-3.1-3.53.3-3.53.5-3.5-3.6-3.6-3.62.5-3.1-0.80.10.5
Patch foraging total patch changes 0 sec0.81.52.3-1.2-1.3-1.4-1.41.4-1.41.4-1.3-1.5-1.4-1.41.0-1.3-0.5-0.10.4
Patch foraging total patch changes 12 sec0.81.12.11.40.90.91.3-1.11.2-1.21.41.21.21.2-0.80.90.1-0.20.3
Patch foraging total patch changes 18 sec0.30.51.00.80.40.60.9-0.80.9-0.91.00.80.90.9-0.40.6-0.40.20.3
Patch foraging total patch changes 24 sec0.40.71.10.70.70.80.9-1.01.0-1.01.00.91.01.1-0.80.9-0.40.5-0.3
Patch foraging total patch changes 6 sec1.52.33.41.61.51.51.7-1.81.8-1.81.71.81.71.7-1.51.70.10.3-0.5
Patch foraging time to switch 0 sec0.91.83.71.71.11.21.7-1.31.6-1.61.91.71.41.4-0.60.90.4-0.60.8
Patch foraging water rate 0 sec0.40.81.8-1.3-0.7-0.7-1.10.7-0.80.8-1.2-0.9-0.8-0.80.4-0.3-1.11.2-1.0
Patch foraging water rate 12 sec0.00.10.60.3-0.00.00.3-0.00.1-0.10.40.10.20.20.0-0.20.4-0.60.8
Patch foraging water rate 18 sec0.81.22.3-0.6-0.6-0.7-0.91.3-1.51.5-1.1-1.3-1.1-1.10.4-1.21.2-1.20.9
Patch foraging water rate 24 sec0.10.10.5-0.20.20.10.0-0.10.0-0.00.10.10.20.2-0.40.2-0.50.7-0.2
Patch foraging water rate 6 sec0.30.51.6-1.0-0.5-0.3-0.70.4-0.50.5-0.8-0.6-0.4-0.50.3-0.1-1.11.3-0.6
Seeking ratio, delayed vs. immediate footshock0.50.62.9-1.0-0.6-0.7-0.60.4-0.30.3-0.4-0.2-0.5-0.31.3-0.2-1.71.4-0.6
Distance traveled before self-admin1.21.62.71.01.01.21.1-1.31.4-1.41.21.41.51.5-0.91.7-0.91.1-1.2
Distance traveled after self-admin6.37.712.13.02.63.03.3-3.13.3-3.33.53.33.33.3-2.02.80.40.2-0.1
Extensor digitorum longus weight3.011.718.74.33.73.73.9-3.43.4-3.43.53.33.23.2-3.82.44.1-2.91.2
Bone: elastic displacement0.20.21.1-0.30.20.1-0.2-0.20.1-0.1-0.30.10.10.2-0.40.4-0.81.0-1.0
Bone: elastic work1.21.57.8-1.5-1.1-1.1-1.10.8-0.70.7-0.9-0.6-0.6-0.61.1-0.3-2.82.2-1.0
Bone: endosteal estimation3.47.510.13.12.93.03.2-3.03.1-3.13.23.13.13.1-2.62.61.0-0.3-0.1
Bone: endosteal perimeter3.67.710.73.33.23.13.1-3.13.0-3.03.02.93.03.0-3.22.61.8-0.8-0.1
Epididymis fat weight2.48.132.63.71.71.92.9-1.31.5-1.52.61.51.61.6-1.7-0.25.7-5.54.1
Delta time in closed arm before/after self-admin1.11.11.81.11.21.41.1-1.01.0-1.01.11.01.31.3-1.11.20.20.1-0.3
Delta time in open arm before/after self-admin0.30.30.90.60.80.50.5-0.60.5-0.50.40.50.10.1-0.50.10.9-0.60.4
Diff in mean of infusions in LGA sessions0.50.63.30.4-0.1-0.10.00.4-0.50.5-0.2-0.4-0.4-0.4-0.2-0.81.8-1.81.3
Delay discount exponential model param0.10.10.4-0.1-0.3-0.2-0.10.2-0.20.2-0.2-0.2-0.1-0.20.0-0.40.6-0.60.3
Extinction: sum of active levers before priming1.31.43.91.51.11.01.3-0.90.9-0.91.10.90.80.8-1.40.32.0-1.81.1
Active lever presses in extinction session 61.01.03.31.30.70.81.0-0.40.4-0.40.90.50.50.5-0.8-0.11.8-1.81.5
Bone: final force0.30.41.20.4-0.10.10.7-0.40.8-0.81.10.80.80.70.40.4-1.00.50.5
Bone: final moment0.30.61.30.60.20.40.9-0.60.9-0.91.21.00.90.90.20.6-0.90.50.2
Food consumed during 24 hour testing period0.70.91.5-1.2-1.1-1.0-1.01.1-1.11.1-1.1-1.1-1.0-1.00.8-1.0-0.10.00.3
Glucose0.91.58.3-1.0-0.00.1-0.5-0.40.3-0.3-0.40.30.10.10.11.0-2.72.9-2.3
Heart weight0.30.42.40.5-0.2-0.00.60.10.1-0.10.60.30.10.10.3-0.51.2-1.31.6
Delay discount hyperbolic model param0.10.10.70.1-0.2-0.00.00.1-0.10.1-0.1-0.1-0.0-0.1-0.1-0.20.8-0.70.3
Intermittent access intake day 1-15 change1.63.35.31.62.32.31.6-2.11.9-1.91.41.81.91.9-1.82.3-0.21.1-1.6
Intermittent access intake escalation1.83.86.11.72.32.41.7-2.32.2-2.21.52.12.02.0-1.92.5-0.11.1-1.7
Intermittent access intake escalation 21.71.93.70.81.71.60.9-1.51.3-1.30.81.21.41.4-1.31.9-0.71.5-1.9
Intermitt. access day 1 inactive lever presses0.31.33.90.21.01.00.5-1.41.4-1.40.40.90.80.8-0.91.5-0.91.7-2.0
Intermitt. access day 15 inactive lever presses0.10.30.90.20.30.40.3-0.40.4-0.40.30.20.60.6-0.10.8-0.70.9-0.9
Intermitt. access escalation Index0.40.51.8-0.2-0.8-0.8-0.30.7-0.60.6-0.2-0.6-0.6-0.60.5-1.10.5-1.01.3
Intermittent access day 1 total infusions2.54.06.72.52.62.52.2-2.12.1-2.12.01.92.02.0-2.11.61.9-1.20.3
Intermittent access day 15 total infusions7.310.916.63.74.14.13.5-3.83.7-3.73.33.53.53.5-3.33.31.8-0.5-0.7
Intermittent access terminal intake (last 3 days)6.58.613.93.63.73.63.2-3.23.2-3.23.02.93.03.0-2.92.62.2-1.1-0.1
Intermittent access total infusions5.46.410.93.03.33.22.7-2.92.8-2.82.52.52.52.5-2.62.31.8-0.8-0.2
Intermittent access day 1 locomotion1.51.93.41.51.41.41.6-1.71.9-1.91.61.51.31.3-0.91.00.7-0.40.4
Intermittent access day 15 total locomotion2.74.97.72.52.82.62.4-2.62.5-2.52.32.42.32.3-2.02.30.50.2-0.5
Intermittent access total locomotion2.53.05.11.92.12.01.8-2.22.3-2.31.81.81.61.6-1.41.60.8-0.2-0.1
Intermittent access standard deviation5.511.418.63.64.34.33.4-3.93.7-3.73.03.43.53.5-3.83.61.6-0.0-1.4
Left kidney weight0.10.63.00.2-0.4-0.10.6-0.30.7-0.71.10.80.80.90.90.5-1.71.10.2
Right kidney weight0.10.42.1-0.2-1.0-0.80.20.30.2-0.20.70.20.20.21.4-0.3-1.30.50.8
Cocaine induced anxiety0.40.51.4-0.9-0.4-0.6-0.90.5-0.50.5-0.9-0.9-0.7-0.70.7-0.4-1.20.8-0.5
Post-drug Anxiety1.01.12.1-0.8-1.1-1.1-1.01.2-1.11.1-0.8-1.3-1.1-1.11.4-1.3-0.4-0.30.9
Baseline Anxiety0.50.63.00.5-0.2-0.20.20.5-0.50.50.1-0.3-0.2-0.2-0.1-0.61.7-1.71.4
Tail length1.03.814.3-0.4-2.2-1.9-0.62.1-1.71.7-0.2-1.6-1.3-1.22.4-2.61.4-2.83.8
Length with tail1.04.214.7-0.6-2.6-2.1-0.72.2-1.61.6-0.2-1.6-1.5-1.42.9-2.80.8-2.43.8
Length without tail0.31.05.60.3-0.9-0.60.20.7-0.40.40.4-0.3-0.5-0.41.0-1.31.2-1.92.4
Times rat made contact with spout1.21.42.2-1.5-1.3-1.3-1.31.3-1.21.2-1.2-1.2-1.2-1.21.2-1.1-1.20.70.1
Lifetime Intake6.37.612.73.33.63.43.0-3.23.1-3.12.72.72.72.7-2.92.42.1-1.0-0.1
Liver weight, left2.84.711.5-0.7-2.4-2.2-1.22.3-1.91.9-0.8-1.9-2.1-2.02.8-3.01.3-2.83.4
Liver weight, right1.52.512.70.4-1.5-1.20.21.1-0.60.60.6-0.6-0.7-0.61.9-2.02.1-3.03.6
Locomotor activity0.40.61.20.90.70.81.0-0.80.9-0.91.11.00.70.8-0.60.60.2-0.10.4
Locomotor testing distance1.83.36.32.11.61.72.3-2.02.2-2.22.52.22.12.1-1.21.6-0.00.10.6
Locomotor testing rearing3.16.28.32.92.72.82.9-2.72.8-2.82.92.82.82.9-2.42.40.8-0.2-0.1
Locomotion in novel chamber2.22.84.90.91.91.81.1-1.81.5-1.50.91.61.71.7-2.02.2-1.11.9-2.2
Locomotion in novel chamber post-restriction0.20.30.9-0.7-0.3-0.5-0.50.3-0.30.3-0.6-0.4-0.3-0.40.3-0.2-0.90.8-0.4
Fecal boli incidents, locomotor time 10.20.30.6-0.7-0.8-0.8-0.60.6-0.50.5-0.5-0.4-0.6-0.60.8-0.5-0.1-0.0-0.1
Change in fecal boli incidents, locomotor task0.20.20.5-0.7-0.5-0.4-0.60.4-0.50.5-0.7-0.6-0.5-0.50.2-0.3-0.40.4-0.3
Time >=10cm from walls, locomotor time 10.50.51.1-0.9-1.1-0.9-0.70.7-0.60.6-0.7-0.8-0.8-0.80.9-0.8-0.30.00.3
Bouts of movement, locomotor time 10.80.91.3-0.9-1.1-1.1-1.01.0-1.01.0-1.1-1.1-1.0-1.10.5-1.00.5-0.50.2
Total resting periods, locomotor time 11.71.93.3-1.6-1.4-1.5-1.61.5-1.61.6-1.8-1.6-1.6-1.60.8-1.40.1-0.1-0.0
Rest time, locomotor task time 10.60.71.6-1.3-1.0-1.0-0.90.6-0.70.7-0.9-0.7-0.6-0.60.4-0.3-1.21.2-0.8
Distance moved, locomotor task time 10.81.12.01.41.31.41.2-1.00.9-0.91.11.01.01.0-1.20.81.2-0.80.3
Vertical activity count, locomotor time 10.30.71.41.21.01.01.0-0.70.7-0.71.00.80.80.8-0.70.40.7-0.70.7
Time >=10cm from walls, locomotor time 20.50.81.7-1.3-0.8-0.6-0.90.8-0.90.9-0.9-1.0-0.7-0.80.7-0.6-1.31.2-0.1
Bouts of movement, locomotor time 20.91.42.6-1.4-1.0-1.2-1.51.2-1.31.3-1.6-1.6-1.4-1.50.7-1.2-0.30.1-0.1
Total resting periods, locomotor time 20.61.12.0-1.1-0.9-1.0-1.21.0-1.11.1-1.4-1.4-1.3-1.30.6-1.1-0.1-0.10.1
Rest time, locomotor task time 20.60.81.4-1.1-1.0-1.0-1.10.9-0.90.9-1.2-1.0-0.9-0.90.6-0.6-0.50.3-0.6
Distance moved, locomotor task time 22.63.15.72.02.22.42.0-1.81.7-1.71.91.82.02.0-2.01.80.50.1-0.2
Vertical activity count, locomotor time 20.60.81.61.01.01.21.1-0.80.9-0.91.30.91.11.1-0.40.7-0.40.20.5
Light reinforcement 11.53.85.92.32.42.22.2-2.01.9-1.92.11.92.22.2-2.41.81.2-0.40.1
Light reinforcement 20.30.40.80.70.80.80.7-0.60.6-0.60.80.70.80.9-0.50.80.10.2-0.2
Bone: marrow area3.37.29.73.12.92.93.1-3.03.0-3.03.13.13.13.0-2.62.61.0-0.3-0.1
Bone: maximum diameter1.22.33.21.51.71.61.6-1.81.7-1.71.61.61.71.7-1.81.60.10.3-0.5
Bone: maximum force0.50.82.10.70.20.41.0-0.81.1-1.11.41.11.11.10.20.7-1.20.60.4
Bone: maximum moment0.61.12.40.90.50.71.2-1.01.3-1.31.61.41.31.3-0.11.0-1.10.70.1
Mean time between licks in bursts0.30.72.21.10.30.41.1-0.40.7-0.71.20.70.70.7-0.2-0.01.0-1.21.5
Mean num. licks in bursts0.10.10.3-0.2-0.2-0.4-0.30.2-0.30.3-0.2-0.5-0.3-0.30.1-0.5-0.0-0.20.5
Cd content in liver2.73.04.72.02.02.11.9-1.81.7-1.71.41.71.71.7-2.21.52.2-1.2-0.2
Co content in liver0.10.10.60.30.20.10.10.0-0.10.10.0-0.10.0-0.0-0.4-0.10.8-0.70.4
Cu content in liver1.41.73.7-1.6-0.8-1.1-1.71.3-1.61.6-1.9-1.5-1.5-1.50.6-0.9-0.30.4-0.8
Fe content in liver0.20.31.50.3-0.4-0.30.20.3-0.10.10.3-0.1-0.1-0.10.7-0.60.6-1.01.2
K content in liver1.00.93.2-0.6-1.4-1.2-0.61.0-0.70.7-0.3-0.8-0.8-0.81.8-1.2-0.3-0.51.3
Mg content in liver0.40.40.6-0.7-0.7-0.7-0.70.7-0.70.7-0.7-0.7-0.7-0.70.6-0.70.0-0.20.2
Mn content in liver1.92.13.3-1.7-1.4-1.4-1.71.6-1.71.7-1.8-1.7-1.7-1.61.4-1.3-0.20.0-0.2
Na content in liver0.20.31.2-0.1-0.3-0.20.2-0.20.5-0.50.50.40.50.40.90.3-1.10.8-0.2
Rb content in liver1.41.74.61.61.61.51.4-1.11.0-1.01.11.01.11.1-1.60.92.2-1.40.4
Se content in liver0.20.30.6-0.8-0.5-0.5-0.60.4-0.40.4-0.7-0.4-0.5-0.50.5-0.2-0.40.5-0.6
Sr content in liver1.11.02.21.20.91.01.1-0.90.9-0.91.00.90.90.9-0.80.61.5-1.10.4
Zn content in liver0.50.51.0-0.4-0.7-0.7-0.50.7-0.70.7-0.6-0.7-0.8-0.80.5-0.90.9-1.00.8
Bone: minimum diameter1.93.45.72.21.81.82.2-2.02.2-2.22.42.12.12.1-1.61.70.3-0.20.3
Time in familiar zone, hab. session 10.40.41.00.60.90.80.5-0.80.6-0.60.40.60.60.6-1.00.70.30.2-0.6
Time in novel zone, hab. session 10.60.61.0-0.8-0.9-0.9-0.71.0-0.80.8-0.7-0.8-0.8-0.80.9-0.9-0.2-0.20.5
Total zone transitions, hab. session 15.27.210.63.33.13.23.1-2.92.8-2.82.92.92.82.9-2.82.51.9-1.00.0
Total locomotion distance, hab. session 10.30.40.60.80.70.70.7-0.50.6-0.60.60.60.60.6-0.60.40.8-0.60.2
Locomotion velocity, hab. session 10.40.60.90.90.90.90.9-0.70.8-0.80.80.80.80.8-0.70.60.7-0.50.1
Time in familiar zone, hab. session 20.30.30.4-0.4-0.4-0.5-0.50.6-0.60.6-0.6-0.6-0.6-0.60.3-0.60.4-0.40.4
Time in novel zone, hab. session 20.20.20.9-0.5-0.3-0.2-0.40.2-0.10.1-0.3-0.1-0.1-0.10.40.1-0.90.9-0.6
Total zone transitions, hab. session 21.92.44.32.11.51.72.0-1.51.6-1.62.01.71.71.8-1.01.11.2-1.00.8
Total locomotion distance, hab. session 20.30.30.90.80.40.50.8-0.50.6-0.60.90.60.70.7-0.00.30.0-0.30.6
Locomotion velocity, hab. session 20.30.41.10.90.50.60.9-0.60.7-0.71.10.80.80.8-0.10.4-0.0-0.20.5
Novel to familiar place preference ratio0.20.20.40.20.60.60.3-0.40.5-0.50.20.50.50.4-0.60.60.50.0-0.6
Novelty place preference0.00.00.3-0.00.20.10.10.00.1-0.1-0.10.10.10.1-0.10.10.5-0.2-0.3
Time in novel zone, NPP test0.00.10.6-0.10.00.0-0.00.1-0.00.0-0.2-0.0-0.0-0.1-0.1-0.00.8-0.4-0.1
Total zone transitions, NPP test2.94.26.52.52.22.42.5-2.12.2-2.22.32.22.22.3-1.91.71.5-0.90.4
Total locomotion distance, NPP test0.50.60.90.70.80.90.8-0.90.9-0.90.80.90.91.0-0.70.9-0.10.4-0.5
Locomotion velocity, NPP test0.50.71.20.50.90.90.7-0.90.9-0.90.70.90.91.0-0.71.1-0.60.9-0.9
Intraocular pressure3.04.48.52.32.92.71.9-2.31.9-1.91.52.02.22.1-2.92.50.80.1-1.6
Delta distance traveled before/after self-admin2.22.34.31.91.21.51.9-1.41.7-1.72.11.61.51.5-0.70.71.6-1.41.4
Delta ambulatory time before/after self-admin0.81.01.81.30.70.91.2-0.91.1-1.11.31.00.80.8-0.40.41.3-1.11.0
Parametrial fat weight3.78.628.63.91.81.93.2-1.61.9-1.93.11.92.02.1-1.90.25.4-5.23.9
Pavlov. Cond. lever latency2.12.63.61.81.71.81.8-1.81.8-1.81.81.91.81.8-1.51.70.8-0.2-0.4
Pavlov. Cond. magazine entry latency3.74.86.9-2.2-2.3-2.3-2.42.5-2.62.6-2.5-2.6-2.5-2.52.0-2.3-0.2-0.40.6
Pavlov. Cond. change in total contacts1.51.62.7-1.6-1.1-1.1-1.61.3-1.41.4-1.6-1.5-1.4-1.41.0-0.9-1.10.9-0.6
Pavlov. Cond. index score2.83.55.1-1.9-2.0-2.0-2.02.2-2.22.2-2.0-2.3-2.2-2.21.7-2.1-0.1-0.50.8
Pavlov. Cond. latency score3.34.25.9-2.0-2.2-2.2-2.22.4-2.42.4-2.1-2.4-2.3-2.42.0-2.3-0.2-0.51.0
Pavlov. Cond. lever contacts2.12.53.5-1.7-1.7-1.7-1.81.8-1.81.8-1.7-1.9-1.8-1.81.6-1.6-0.60.00.4
Pavlov. Cond. magazine entry number1.82.23.71.61.31.41.8-1.61.9-1.91.91.91.81.8-1.11.4-0.00.2-0.1
Pavlov. Cond. intertrial magazine entries3.44.15.62.32.32.22.3-2.42.2-2.22.12.32.22.2-2.32.00.9-0.2-0.3
Pavlov. Cond. lever-magazine prob. diff.2.63.24.7-1.8-1.8-1.8-2.02.0-2.12.1-2.0-2.2-2.1-2.11.5-1.9-0.1-0.40.5
Pavlov. Cond. response bias2.22.84.3-1.6-1.5-1.6-1.91.9-2.02.0-2.0-2.1-2.0-2.01.3-1.7-0.0-0.40.4
Pavlov. Cond. lever latency0.60.84.50.90.20.30.7-0.00.2-0.20.60.20.30.3-0.2-0.42.1-2.01.5
Pavlov. Cond. magazine entry latency0.81.02.0-1.2-1.0-1.0-1.10.9-0.90.9-1.0-0.9-0.8-0.81.3-0.6-1.41.1-0.5
Pavlov. Cond. change in total contacts0.50.82.8-1.1-0.7-0.7-1.00.6-0.70.7-0.9-0.7-0.7-0.70.9-0.2-1.71.4-0.8
Pavlov. Cond. index score0.60.84.4-0.9-0.2-0.2-0.70.0-0.20.2-0.6-0.2-0.2-0.20.40.4-2.12.0-1.6
Pavlov. Cond. latency score0.70.95.1-0.9-0.1-0.2-0.6-0.1-0.10.1-0.5-0.1-0.1-0.10.40.6-2.32.2-1.7
Pavlov. Cond. lever contacts0.50.73.3-0.9-0.5-0.6-0.80.3-0.50.5-0.7-0.4-0.5-0.50.6-0.1-1.81.5-0.9
Pavlov. Cond. magazine entry number0.40.52.20.90.60.60.7-0.40.4-0.40.60.40.50.5-0.90.11.5-1.20.8
Pavlov. Cond. intertrial magazine entries0.60.82.21.21.00.91.0-0.80.6-0.60.80.70.80.7-1.20.41.5-1.20.7
Pavlov. Cond. lever-magazine prob. diff.0.60.84.2-0.9-0.2-0.2-0.70.0-0.20.2-0.6-0.2-0.2-0.20.50.4-2.12.0-1.6
Pavlov. Cond. response bias0.81.13.5-1.3-0.8-0.9-1.20.7-0.80.8-1.1-0.8-0.9-0.80.9-0.3-1.91.6-1.0
Time in closed arm before self-admin2.53.26.2-1.6-2.5-2.4-1.62.0-1.71.7-1.4-1.7-1.9-1.92.4-2.1-0.1-0.81.3
Time in closed arm after self-admin0.80.82.4-1.0-1.5-1.2-0.90.9-0.70.7-0.6-0.8-0.7-0.71.6-0.7-0.90.40.1
Time in open arm before self-admin0.50.62.6-0.30.60.5-0.1-0.30.1-0.1-0.10.20.40.4-0.50.8-1.51.6-1.5
Time in open arm after self-admin1.51.64.20.82.11.60.9-1.51.2-1.20.61.21.01.0-1.71.5-0.11.0-1.4
Bone: periosteal estimation1.83.86.02.11.81.92.3-2.22.3-2.32.42.32.32.3-1.61.9-0.20.3-0.1
Bone: periosteal perimeter1.32.33.11.71.61.51.7-1.71.8-1.81.71.71.81.7-1.71.50.30.0-0.2
Bone: post-yield work0.30.41.90.7-0.00.10.50.10.0-0.00.50.10.10.00.0-0.41.2-1.41.3
Progressive ratio test 1 active lever presses1.62.04.41.82.11.91.5-1.51.4-1.41.31.31.21.2-1.41.21.4-0.7-0.0
Progressive ratio test 1 breakpoint1.92.34.91.92.22.11.6-1.61.5-1.51.41.41.41.4-1.51.31.5-0.80.0
Progressive ratio test 1 inactive lever presses2.74.06.32.12.32.42.1-2.42.5-2.52.12.12.12.1-1.62.20.20.5-0.8
Progressive ratio test 2 active lever presses1.11.33.31.51.81.51.0-1.10.8-0.80.70.70.70.7-1.50.81.8-1.10.0
Progressive ratio test 2 breakpoint1.41.63.71.71.91.61.2-1.21.0-1.00.80.80.80.8-1.60.91.9-1.20.0
Progressive ratio test 2 inactive lever presses2.23.55.62.22.42.32.0-2.12.1-2.11.81.91.81.8-2.01.81.4-0.6-0.3
Incentive Sensitization - Responses0.20.31.70.60.70.40.3-0.20.0-0.00.0-0.00.00.0-0.80.01.3-1.00.2
Incentive Sensitization - Breakpoint0.20.31.50.70.70.50.3-0.30.1-0.10.10.00.10.1-0.80.11.2-1.00.3
Sum of active levers in priming session hrs 5-61.11.03.9-0.1-0.6-0.6-0.30.7-0.70.7-0.5-0.7-0.9-0.90.0-1.31.8-2.01.6
Progressive ratio1.01.62.71.11.21.21.4-1.41.6-1.61.51.71.41.4-0.81.4-0.70.9-0.4
Food seeking constrained by brief footshock0.20.21.5-0.2-0.1-0.10.1-0.10.1-0.10.30.30.30.30.20.3-1.21.1-0.2
Seeking ratio, punishment vs. effort1.01.42.3-1.5-1.4-1.5-1.41.3-1.31.3-1.2-1.4-1.2-1.11.2-1.1-0.80.30.1
Retroperitoneal fat weight0.41.83.81.91.51.61.5-1.00.9-0.91.31.01.41.4-1.50.91.9-1.50.6
Reaction time number correct0.10.20.5-0.4-0.6-0.4-0.30.5-0.40.4-0.3-0.2-0.5-0.50.7-0.60.2-0.20.5
Reaction time mean minus median0.10.21.2-0.20.40.1-0.50.1-0.30.3-0.7-0.2-0.3-0.2-0.40.20.10.2-1.1
Reaction time mean minus median AUC0.10.31.40.50.90.6-0.0-0.2-0.10.1-0.40.00.00.1-1.00.41.2-0.7-0.7
Reaction time num false alarms0.50.71.7-1.1-0.3-0.5-1.00.6-0.90.9-1.3-0.8-0.8-0.7-0.1-0.2-0.71.0-1.2
Reaction time num false alarms AUC0.40.61.4-1.0-0.2-0.4-0.90.5-0.80.8-1.1-0.6-0.6-0.6-0.2-0.1-0.71.0-1.2
Reaction time trials correct on left0.10.20.5-0.4-0.6-0.4-0.30.5-0.40.4-0.3-0.2-0.5-0.50.7-0.60.2-0.20.5
Reaction time trials on left0.10.20.4-0.4-0.6-0.3-0.30.4-0.40.4-0.3-0.2-0.4-0.50.6-0.50.2-0.20.4
Reaction time mean0.00.10.2-0.10.1-0.0-0.30.2-0.40.4-0.4-0.2-0.2-0.2-0.20.0-0.00.0-0.5
Reaction time mean AUC0.10.10.7-0.30.1-0.0-0.40.2-0.40.4-0.6-0.2-0.2-0.2-0.20.1-0.40.5-0.8
Median of all reaction times0.00.00.1-0.00.0-0.1-0.20.2-0.30.3-0.2-0.0-0.1-0.0-0.20.0-0.20.1-0.3
Reaction time omissions0.20.41.10.71.00.90.5-0.40.2-0.20.30.50.50.5-1.10.40.9-0.3-0.1
Reaction time false alarm rate0.20.31.2-0.60.0-0.2-0.70.2-0.50.5-0.9-0.5-0.4-0.3-0.50.1-0.60.8-1.1
Reaction time premature initiation rate1.82.53.7-1.8-1.5-1.7-1.81.7-1.91.9-1.9-1.8-1.9-1.91.1-1.7-0.30.00.4
Reaction time premature initiations1.42.43.6-1.7-1.5-1.6-1.71.7-1.81.8-1.8-1.7-1.9-1.91.3-1.7-0.1-0.10.5
Std. dev. reaction times0.30.51.4-0.8-0.1-0.4-1.00.6-0.90.9-1.2-0.7-0.8-0.7-0.0-0.2-0.30.5-1.1
Reaction time trials completed0.10.20.4-0.4-0.6-0.3-0.30.4-0.40.4-0.3-0.2-0.4-0.50.6-0.50.2-0.20.4
Reaction time trials AUC0.10.20.3-0.4-0.5-0.3-0.30.4-0.40.4-0.3-0.2-0.5-0.50.6-0.50.1-0.20.4
Run reversals in cocaine runway, females0.00.00.20.20.40.4-0.0-0.1-0.00.0-0.10.10.00.2-0.30.20.3-0.1-0.4
Run reversals in cocaine runway, males2.82.84.91.61.81.71.7-2.01.8-1.81.61.81.81.8-2.21.90.40.4-0.8
Latency to leave start box in cocaine runway0.10.10.7-0.1-0.1-0.00.00.1-0.00.00.10.20.10.10.3-0.0-0.80.50.1
Latency to leave start box in cocaine runway, F0.20.20.7-0.3-0.5-0.4-0.20.5-0.30.3-0.0-0.1-0.4-0.20.9-0.6-0.60.00.8
Latency to leave start box in cocaine runway, M0.60.50.80.60.60.70.8-0.80.8-0.80.80.80.90.8-0.60.9-0.20.4-0.4
Std. dev. time between licks in bursts0.10.20.50.50.00.10.6-0.30.5-0.50.70.50.40.4-0.00.10.4-0.40.7
Total sessions with >9 infusions3.84.68.22.62.92.72.3-2.42.3-2.32.02.12.02.0-2.31.82.0-1.00.0
Short access day 1 total inactive lever presses0.50.61.90.70.50.60.8-1.21.4-1.40.80.80.40.4-0.60.60.6-0.2-0.1
Short access day 10 total inactive lever presses0.40.91.80.20.30.40.6-1.21.3-1.30.71.10.80.8-0.41.2-0.81.3-1.3
Short access day 1 total infusions4.56.09.62.53.12.92.5-3.12.9-2.92.22.62.32.3-2.82.51.00.1-1.0
Short access day 10 total infusions2.93.88.02.22.82.61.9-2.21.9-1.91.51.81.81.8-2.61.91.6-0.6-0.6
Short access total infusions5.67.112.33.03.53.32.8-3.13.0-3.02.52.72.72.7-3.02.61.5-0.4-0.6
Short access day 1 locomotion1.62.03.51.21.91.71.2-1.81.6-1.61.01.51.21.2-1.81.70.50.5-1.2
Short access day 10 total locomotion1.12.14.01.11.61.61.3-2.02.0-2.01.21.61.31.3-1.21.60.30.6-1.1
Short access total locomotion1.31.62.90.81.51.51.0-1.71.7-1.70.91.31.01.0-1.01.5-0.21.0-1.3
One hour access (0.3 mA shock)4.04.68.62.72.92.62.2-2.32.1-2.11.91.91.91.9-2.71.72.5-1.60.2
Compulsive drug intake1.21.42.5-0.9-1.4-1.3-1.01.2-1.01.0-0.9-1.3-1.5-1.51.2-1.60.7-1.21.3
One hour access (shock baseline)2.23.35.62.12.42.11.9-2.01.9-1.91.81.92.02.0-2.11.81.3-0.5-0.4
Social response proportion3.84.37.1-1.5-2.2-2.1-1.82.3-2.22.2-1.7-2.3-2.3-2.42.2-2.70.9-1.72.1
Social responses0.60.83.61.20.30.61.1-0.20.4-0.41.20.50.60.5-0.1-0.21.2-1.51.9
Social time0.30.42.80.60.00.10.5-0.00.1-0.10.6-0.00.00.0-0.0-0.51.0-1.21.7
Soleus weight0.92.713.81.6-0.20.01.20.10.2-0.21.30.20.30.30.2-1.13.3-3.73.4
Bone: stiffness0.60.94.31.2-0.10.21.2-0.30.7-0.71.50.70.60.60.5-0.30.9-1.52.1
Tibialis anterior weight2.27.420.63.72.52.53.0-2.32.2-2.22.72.12.02.1-2.71.04.5-3.82.2
Time to tail flick, vehicle, before self-admin0.90.94.50.2-0.6-0.7-0.20.7-0.60.6-0.2-0.7-0.7-0.70.5-1.11.8-2.11.5
Time to tail flick, vehicle, after self-admin0.10.10.40.3-0.1-0.10.10.1-0.00.00.2-0.00.00.00.3-0.20.3-0.60.6
Time to tail flick, test, before self-admin6.56.89.4-2.9-3.1-3.0-2.82.9-2.72.7-2.5-2.7-2.9-2.92.9-2.7-1.60.50.8
Time to tail flick, test, after self-admin1.61.63.1-1.6-1.6-1.8-1.31.3-1.11.1-1.1-1.1-1.2-1.21.6-1.1-1.40.80.0
Delta time to tail flick, vehicle, before/after SA2.01.93.01.11.61.61.2-1.61.5-1.51.11.51.51.5-1.51.7-0.20.9-1.2
Delta time to tail flick, test, before/after SA2.82.94.61.72.11.91.7-1.91.8-1.81.51.81.91.9-2.11.90.80.1-0.9
Tibia length1.23.47.6-1.4-2.5-2.2-1.52.1-1.81.8-1.1-1.8-1.8-1.82.8-2.3-0.5-0.71.9
Ambulatory time before self-admin0.71.01.60.70.70.80.9-1.01.1-1.11.01.11.31.3-0.51.3-1.11.1-0.9
Ambulatory time after self-admin2.22.65.61.81.11.62.0-1.72.0-2.02.41.92.02.0-0.61.40.1-0.00.6
Bone: tissue strength0.30.30.50.20.40.50.4-0.50.6-0.60.50.70.70.6-0.10.7-0.60.7-0.6
Total heroin consumption1.41.78.10.5-0.4-0.30.10.6-0.50.5-0.0-0.6-0.8-0.80.0-1.52.6-2.82.6
Bone: trabecular number1.22.03.8-0.7-1.3-1.3-0.91.5-1.41.4-1.1-1.4-1.5-1.41.1-1.81.7-1.91.5
Bone: trabecular spacing1.01.32.80.91.61.40.9-1.31.1-1.10.61.11.01.0-1.71.40.30.5-1.2
Bone: trabecular thickness0.30.41.4-0.3-1.0-0.8-0.10.6-0.30.30.1-0.4-0.2-0.21.2-0.8-0.3-0.31.1
Bone: trabecular tissue density0.81.36.4-1.4-0.6-0.7-1.10.5-0.60.6-0.9-0.6-0.4-0.50.70.0-2.52.2-1.3
Water consumed over 24 hours3.75.07.3-2.7-2.5-2.3-2.52.5-2.42.4-2.5-2.4-2.5-2.52.4-2.1-1.30.60.2
Number of responses in last shaping day1.11.23.30.21.21.10.5-1.41.2-1.20.41.00.80.8-1.01.5-0.91.7-1.8