Hub : Genes

Itga1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA gene expression Itga1 0.1 0.07 2.9e-03 0.07 0.03 0.02 0.05 7.5e-04 2.9e-02 5.3e-02 3.1e-03
2 PL gene expression Itga1 0.03 0.02 9.6e-04 0.01 0.02 0.02 0.02 5.3e-02 1.4e-03 6.6e-03 6.2e-03
3 Adipose gene expression Itga1 0.15 0.06 5.0e-16 0.13 0.12 0.12 0.12 2.7e-14 4.1e-13 1.2e-13 3.0e-13
4 Brain mRNA stability Itga1 0.05 0.03 1.1e-04 0.05 0.04 0.03 0.04 2.7e-05 1.7e-04 1.5e-03 5.0e-05
5 RMTg gene expression Itga1 0.14 0.08 3.3e-03 0.05 0 -0.01 0.03 1.9e-02 3.2e-01 6.4e-01 7.3e-02
6 Adipose alternative polyA XM_039101763.1 0.04 0.03 7.5e-04 0.01 0.02 0.01 0.02 5.2e-02 3.8e-03 3.5e-02 6.3e-03
7 Adipose alternative polyA NM_030994.2 0.04 0.03 7.1e-04 0.01 0.02 0.01 0.01 5.2e-02 4.1e-03 4.6e-02 7.4e-03
8 Brain gene expression Itga1 0.16 0.07 5.6e-15 0.19 0.17 0.17 0.17 1.3e-17 1.3e-15 1.3e-15 6.4e-16
9 BLA gene expression Itga1 0.09 0.06 2.6e-03 0.04 0.04 0.04 0.03 3.0e-03 2.3e-03 2.2e-03 5.9e-03
10 NAcc gene expression Itga1 0.03 0.02 1.6e-03 0.02 0.02 0.02 0.02 8.3e-04 1.1e-03 2.4e-03 1.2e-03
11 RMTg isoform ratio XM_039101763.1 0.16 0.1 5.9e-03 0.09 0.07 0.1 0.1 2.2e-03 6.4e-03 1.2e-03 1.4e-03
12 IL gene expression Itga1 0.59 0.19 9.1e-03 -0 -0.01 0.02 -0.01 4.5e-01 8.4e-01 1.1e-01 6.9e-01
13 Adipose mRNA stability Itga1 0.04 0.02 4.0e-03 0.01 0 0.01 0 1.9e-02 1.8e-01 4.1e-02 1.4e-01
14 Liver gene expression Itga1 0.17 0.06 1.6e-11 0.09 0.07 0.08 0.08 1.2e-09 2.1e-08 2.5e-09 3.0e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density2.84.79.5-2.41.8-2.7-2.7-2.6-3.13.1-2.1-0.6-0.52.6-1.7-1.5-0.3
Area under the delay curve1.21.22.90.00.11.31.31.21.5-1.51.0-1.3-0.3-1.71.30.8-0.3
BMI with tail0.93.19.5-2.11.4-1.9-1.9-1.1-2.12.1-1.0-1.9-1.30.9-0.2-3.1-1.8
BMI without tail2.65.410.4-2.92.5-2.9-2.9-3.2-2.82.8-2.8-1.7-1.51.80.5-1.4-0.3
Body weight1.87.713.3-3.62.9-3.4-3.4-3.0-3.53.5-3.0-2.0-1.92.4-1.7-1.7-1.0
Weight adjusted by age0.30.32.40.30.1-0.6-0.6-0.40.1-0.1-0.50.6-0.30.4-1.60.30.2
Bone surface1.93.47.5-1.50.8-2.2-2.2-1.6-2.72.7-1.4-0.30.32.4-1.9-2.2-1.2
Bone volume1.62.75.7-1.40.7-1.9-1.9-1.4-2.42.4-1.0-0.30.22.0-1.8-2.2-1.2
Breakpoint value in progressive ratio session0.20.21.00.60.3-0.1-0.1-0.00.4-0.40.1-0.3-0.7-0.3-0.20.31.0
Number of licking bursts0.30.42.20.00.3-0.1-0.1-0.30.4-0.4-0.10.3-0.7-0.61.10.51.5
Context. condit. distance diff. score0.70.82.80.0-1.1-0.1-0.1-0.1-1.11.10.21.71.51.4-0.6-0.70.1
Locomotion velocity, session 10.20.20.60.7-0.70.20.20.3-0.00.00.40.80.70.4-0.6-0.3-0.7
Locomotion distance, session 11.92.45.8-1.00.1-1.5-1.5-1.1-2.32.3-1.30.30.62.4-2.0-1.6-1.7
Locomotion velocity, session 20.60.61.7-0.31.2-1.0-1.0-1.1-0.20.2-1.3-0.5-1.10.30.10.90.4
Locomotion distance, session 21.41.94.3-1.20.4-1.5-1.5-0.9-2.12.1-1.30.0-0.11.9-1.7-1.7-0.9
Locomotion velocity, session 30.60.75.10.20.8-0.2-0.2-0.60.8-0.8-0.7-0.4-0.6-0.30.72.30.9
Locomotion distance, session 30.10.21.40.2-0.10.30.30.00.3-0.3-0.10.10.60.1-0.21.2-0.2
Stereotopy head waving bouts, day 33.03.68.4-1.92.9-2.1-2.1-2.4-0.80.8-2.4-2.1-2.8-0.01.71.00.9
Stereotopy head waving duration, day 31.72.04.9-1.22.1-1.2-1.2-1.7-0.10.1-1.5-1.4-2.2-0.51.91.01.5
Locomotion velocity, session 70.10.20.40.6-0.30.40.40.20.6-0.60.4-0.00.4-0.2-0.10.2-0.4
Locomotion distance, session 70.70.91.91.2-0.81.21.21.01.4-1.41.10.30.4-1.10.60.50.3
Stereotopy head waving bouts, day 70.60.71.6-0.81.1-1.2-1.2-1.0-0.60.6-0.8-0.7-1.30.20.2-0.30.4
Stereotopy head waving duration, day 70.70.82.0-0.71.2-1.3-1.3-1.4-0.70.7-1.1-0.5-0.90.60.50.50.7
Locomotion velocity, session 80.40.51.41.2-1.20.60.60.90.4-0.40.71.00.70.1-0.6-0.5-0.5
Locomotion distance, session 81.52.25.8-0.1-1.2-0.8-0.8-0.1-2.02.0-0.31.61.32.3-1.9-2.4-1.0
Degree of sensitization distance0.50.51.21.1-0.60.50.50.70.7-0.70.70.7-0.2-0.60.7-0.10.9
Degree of sensitization stereotypy0.20.20.5-0.40.4-0.7-0.7-0.5-0.50.5-0.3-0.1-0.40.4-0.1-0.20.3
Conditioned locomotion0.40.51.3-0.81.1-0.9-0.9-0.8-0.50.5-0.9-0.7-1.20.1-0.2-0.00.1
Cocaine response after cond. corrected1.31.53.0-1.71.4-1.1-1.1-1.4-1.21.2-0.8-1.7-0.70.3-0.6-1.3-1.6
Cocaine response after cond. not corrected0.40.52.0-0.40.40.20.2-0.20.1-0.10.4-1.4-0.4-0.8-0.1-1.2-1.4
Cocaine response before conditioning4.85.811.13.3-2.73.13.13.02.8-2.82.81.61.6-1.90.80.80.7
Saline control response0.10.20.40.50.00.10.10.60.5-0.50.3-0.3-0.5-0.4-0.7-0.3-0.6
Bone: connectivity density2.64.07.9-1.91.6-2.5-2.5-2.5-2.82.8-2.2-0.3-0.32.6-1.6-0.80.1
Bone: cortical apparent density4.66.010.83.0-2.73.33.33.03.0-3.03.11.41.4-2.30.40.40.6
Bone: cortical area0.20.41.1-0.8-0.0-0.3-0.3-0.1-0.90.9-0.3-0.1-0.10.7-1.0-1.0-0.4
Bone: cortical porosity1.21.32.3-1.41.1-1.5-1.5-1.2-1.51.5-1.3-0.4-0.51.2-0.3-0.50.2
Bone: cortical porosity1.21.32.2-1.51.1-1.5-1.5-1.0-1.41.4-1.1-0.9-0.90.9-0.4-1.3-0.3
Bone: cortical thickness0.50.81.80.8-1.41.31.31.10.6-0.61.01.10.8-0.3-0.80.10.4
Bone: cortical thickness2.02.34.21.7-1.42.02.01.92.1-2.11.90.50.7-1.6-0.10.80.2
Bone: cortical tissue density4.45.710.12.9-2.53.23.22.93.0-3.03.11.31.3-2.30.40.30.6
Condit. Reinf. active minus inactive responses1.01.12.71.6-1.51.11.11.51.0-1.01.40.60.8-0.50.2-0.2-0.7
Condit. Reinf. active-inactive response ratio1.21.32.91.6-1.21.21.21.71.4-1.41.30.50.0-1.21.00.20.2
Condit. Reinf. active responses1.01.22.51.4-1.41.21.21.60.9-0.91.50.20.8-0.60.2-0.8-1.2
Condit. Reinf. inactive responses0.70.93.80.0-0.60.60.60.7-0.20.21.0-0.40.7-0.0-1.1-1.9-2.0
Incentive salience index mean0.30.41.00.7-1.00.40.40.6-0.20.20.60.50.90.5-0.2-0.6-0.8
Condit. Reinf. lever presses0.81.02.5-0.8-0.1-0.6-0.6-0.6-1.61.6-0.4-0.00.81.5-1.1-1.4-1.3
Condit. Reinf. active minus inactive responses1.72.24.32.1-2.01.41.41.81.1-1.11.71.11.6-0.2-1.7-0.2-1.7
Condit. Reinf. active-inactive response ratio1.61.75.11.8-1.70.80.81.20.4-0.41.00.91.30.4-2.2-0.8-2.3
Condit. Reinf. active responses0.81.12.41.5-1.31.21.21.20.9-0.90.91.11.3-0.0-0.81.1-0.3
Condit. Reinf. inactive responses0.60.72.70.6-0.21.01.00.61.0-1.00.40.20.1-0.70.81.71.2
Condit. Reinf. lever presses4.56.213.63.7-3.72.72.72.91.9-1.92.73.43.0-0.5-0.70.70.2
Condit. Reinf. lever reinforcers received1.42.04.32.1-1.81.61.61.71.3-1.31.51.41.6-0.3-0.91.0-0.3
Conditioned reinforcement - actives0.20.21.11.0-0.3-0.1-0.1-0.00.3-0.3-0.40.70.20.2-0.10.70.3
Conditioned reinforcement - inactives0.50.63.71.9-1.00.40.40.60.8-0.80.40.70.8-0.20.80.20.1
Conditioned locomotion0.10.10.40.30.00.30.30.60.4-0.40.2-0.3-0.1-0.40.10.60.0
Patch foraging indifference point 0 sec1.52.45.62.0-2.41.31.31.70.6-0.61.72.32.40.4-1.60.00.1
Patch foraging indifference point AUC0.40.41.8-0.30.6-0.7-0.7-0.9-0.40.4-1.00.3-0.60.4-0.10.41.3
Delay disc. indifference point, 0s delay0.70.81.80.30.20.80.80.61.3-1.30.5-0.8-0.2-1.21.21.4-0.1
Delay disc. indifference point, 16s delay0.30.30.70.5-0.70.80.80.80.5-0.50.70.20.6-0.5-0.0-0.3-0.4
Delay disc. indifference point, 2s delay0.60.73.7-0.81.3-0.2-0.2-0.10.4-0.4-0.3-1.9-1.3-0.80.10.4-0.6
Delay disc. indifference point, 24s delay0.20.21.2-0.50.50.20.20.30.1-0.10.1-1.1-0.1-0.20.00.3-0.9
Delay disc. indifference point, 4s delay2.32.46.30.40.31.71.71.32.1-2.11.2-1.7-0.9-2.52.21.00.4
Delay disc. indifference point, 8s delay0.90.93.7-1.10.60.80.80.50.8-0.80.5-1.3-0.5-1.31.91.00.4
Indifference point function ln k0.71.02.31.1-1.11.21.21.31.0-1.01.50.11.0-0.70.60.2-0.7
Indifference point function log k0.71.02.31.1-1.11.21.21.31.0-1.01.50.11.0-0.70.60.2-0.7
Patch foraging total patch changes 0 sec1.21.94.51.9-2.11.21.21.50.6-0.61.52.12.00.2-1.40.10.3
Patch foraging total patch changes 12 sec0.30.42.10.2-0.50.10.10.1-0.30.30.01.30.60.40.20.41.4
Patch foraging total patch changes 18 sec0.50.61.60.6-1.01.01.01.30.6-0.61.20.60.8-0.5-0.6-0.30.0
Patch foraging total patch changes 24 sec0.30.31.10.8-0.4-0.0-0.00.30.2-0.20.11.00.50.4-0.71.00.7
Patch foraging total patch changes 6 sec0.30.42.50.7-0.6-0.0-0.00.3-0.40.30.20.90.60.6-1.6-0.5-0.2
Patch foraging time to switch 0 sec0.30.41.6-0.8-0.00.00.00.3-0.60.60.3-0.30.20.2-1.1-1.2-1.3
Patch foraging water rate 0 sec1.01.67.20.80.30.60.60.11.5-1.50.1-0.3-0.5-1.22.72.21.9
Patch foraging water rate 12 sec1.01.53.9-0.92.0-1.4-1.4-1.5-0.40.4-1.5-2.0-1.40.4-0.50.6-0.5
Patch foraging water rate 18 sec0.30.41.30.30.8-0.7-0.7-0.40.1-0.1-0.6-1.0-0.80.2-0.30.0-1.1
Patch foraging water rate 24 sec0.20.31.50.30.1-0.5-0.5-0.2-0.20.2-0.2-0.20.40.6-0.8-0.4-1.2
Patch foraging water rate 6 sec0.50.71.81.10.20.60.60.21.3-1.30.4-1.0-0.5-1.20.80.5-0.4
Seeking ratio, delayed vs. immediate footshock0.81.03.1-1.71.7-0.5-0.5-0.6-0.30.3-0.7-1.8-1.5-0.40.70.20.2
Distance traveled before self-admin1.11.23.3-0.6-0.4-1.0-1.0-0.7-1.61.6-1.01.21.41.8-0.3-0.3-0.7
Distance traveled after self-admin0.50.62.40.4-1.20.30.30.3-0.30.30.31.61.50.7-0.9-0.3-0.4
Extensor digitorum longus weight1.55.912.8-2.81.8-2.8-2.8-2.9-3.63.6-2.90.1-0.03.40.20.41.0
Bone: elastic displacement0.20.21.3-1.10.6-0.3-0.3-0.4-0.40.4-0.5-0.4-0.50.1-0.00.20.2
Bone: elastic work0.50.61.8-1.40.7-0.3-0.30.1-0.30.30.1-1.2-0.8-0.4-1.2-1.1-1.0
Bone: endosteal estimation1.53.27.3-2.71.9-1.8-1.8-1.5-1.91.9-1.0-2.5-1.20.6-0.1-2.4-1.8
Bone: endosteal perimeter2.44.98.5-2.92.2-2.7-2.7-1.9-2.72.7-2.0-2.1-1.61.6-0.9-2.3-1.5
Epididymis fat weight0.71.62.8-1.61.7-1.4-1.4-1.5-0.90.9-1.0-1.5-1.7-0.01.1-0.90.3
Delta time in closed arm before/after self-admin0.60.62.1-0.40.80.10.1-0.10.6-0.60.2-1.4-1.1-1.01.30.2-0.5
Delta time in open arm before/after self-admin1.31.34.30.7-1.80.80.80.7-0.20.20.82.12.10.6-1.4-0.6-0.3
Diff in mean of infusions in LGA sessions0.60.71.61.2-0.40.80.80.81.3-1.31.0-0.3-0.3-1.1-0.6-0.2-0.5
Delay discount exponential model param1.31.33.40.2-0.3-1.3-1.3-1.2-1.51.5-1.01.60.61.8-1.3-0.60.4
Extinction: sum of active levers before priming0.40.41.30.80.8-0.4-0.4-0.60.5-0.5-0.8-0.8-1.1-0.3-0.10.60.5
Active lever presses in extinction session 60.40.42.20.20.9-0.2-0.2-0.40.4-0.4-0.2-1.5-1.3-0.50.2-0.2-0.4
Bone: final force1.01.76.00.5-1.30.10.10.9-0.80.80.70.81.11.0-2.5-2.3-2.1
Bone: final moment1.01.76.20.1-1.0-0.2-0.20.7-1.11.10.50.50.91.1-2.4-2.5-2.3
Food consumed during 24 hour testing period0.60.71.71.0-1.30.70.71.20.3-0.30.90.90.90.1-0.8-0.7-0.7
Glucose0.10.10.7-0.3-0.10.00.00.20.1-0.1-0.00.2-0.4-0.30.5-0.10.9
Heart weight0.60.81.4-0.91.2-1.1-1.1-1.0-0.80.8-0.9-1.2-0.90.20.2-0.6-0.9
Delay discount hyperbolic model param1.21.23.30.2-0.6-1.0-1.0-1.0-1.41.4-0.71.70.91.8-1.3-0.60.3
Intermittent access intake day 1-15 change1.41.34.70.6-0.61.11.11.31.3-1.30.80.70.3-0.81.01.72.2
Intermittent access intake escalation1.41.43.80.6-0.61.21.21.51.4-1.41.00.60.2-1.00.91.51.9
Intermittent access intake escalation 21.91.95.20.5-1.01.51.51.51.5-1.51.31.10.6-1.11.31.62.3
Intermitt. access day 1 inactive lever presses0.50.62.30.4-0.90.20.20.4-0.50.50.21.41.50.8-1.0-0.30.1
Intermitt. access day 15 inactive lever presses0.50.61.1-0.51.0-1.0-1.0-0.8-0.50.5-1.0-0.8-0.80.31.1-0.10.2
Intermitt. access escalation Index2.82.54.9-1.21.3-2.0-2.0-2.2-1.91.9-2.20.1-0.42.0-1.80.3-0.2
Intermittent access day 1 total infusions0.30.30.8-0.50.9-0.7-0.7-0.6-0.30.3-0.7-0.9-0.80.00.20.1-0.2
Intermittent access day 15 total infusions0.80.82.6-0.50.50.50.50.60.9-0.90.2-0.6-0.6-1.01.41.61.6
Intermittent access terminal intake (last 3 days)0.50.62.9-0.40.60.20.2-0.00.6-0.6-0.1-0.5-0.5-0.61.01.41.7
Intermittent access total infusions0.40.41.2-0.91.1-0.5-0.5-0.6-0.10.1-0.7-0.9-1.0-0.20.10.70.6
Intermittent access day 1 locomotion0.00.00.3-0.50.3-0.0-0.00.1-0.10.1-0.1-0.3-0.3-0.1-0.10.0-0.2
Intermittent access day 15 total locomotion0.50.51.5-0.50.30.60.60.90.8-0.80.6-0.8-0.9-1.21.00.0-0.0
Intermittent access total locomotion0.20.20.6-0.50.20.50.50.80.4-0.40.4-0.5-0.3-0.70.40.1-0.0
Intermittent access standard deviation2.93.16.11.2-0.71.81.81.72.4-2.41.50.10.0-2.02.12.12.5
Left kidney weight0.20.71.5-0.51.1-0.9-0.9-1.0-0.30.3-1.2-0.4-1.10.3-0.31.01.0
Right kidney weight0.30.72.30.11.1-1.2-1.2-1.0-0.10.1-1.2-0.5-1.50.1-0.80.00.5
Cocaine induced anxiety0.20.20.60.7-0.50.00.00.20.3-0.30.10.80.50.2-0.50.30.5
Post-drug Anxiety0.10.20.90.9-0.5-0.1-0.10.20.1-0.10.10.80.40.3-0.20.20.2
Baseline Anxiety0.20.21.6-0.60.4-0.1-0.1-0.0-0.10.10.0-0.6-0.6-0.31.3-0.0-0.6
Tail length1.54.510.7-2.02.8-2.7-2.7-3.3-1.71.7-3.2-1.2-1.71.6-0.21.30.9
Length with tail0.93.46.4-2.32.5-2.2-2.2-2.4-1.71.7-2.5-1.1-1.61.4-0.71.41.2
Length without tail0.10.21.1-0.60.40.00.00.6-0.10.10.4-0.6-0.6-0.2-1.1-0.2-0.4
Times rat made contact with spout1.92.24.4-1.20.9-2.1-2.1-1.6-2.12.1-1.70.2-0.32.0-0.7-1.10.2
Lifetime Intake0.20.20.7-0.50.7-0.2-0.2-0.20.1-0.1-0.3-0.8-0.8-0.4-0.20.40.2
Liver weight, left0.40.61.90.30.10.30.30.30.9-0.90.5-0.1-1.1-1.30.7-0.61.4
Liver weight, right1.22.04.61.7-2.11.51.52.00.8-0.82.11.51.1-0.7-0.6-1.4-0.2
Locomotor activity2.84.59.0-3.02.9-2.4-2.4-2.6-1.91.9-2.3-2.6-2.11.1-0.8-0.5-1.2
Locomotor testing distance1.42.45.9-2.41.9-1.6-1.6-1.9-1.71.7-1.5-1.6-0.91.2-1.0-0.3-1.1
Locomotor testing rearing0.71.14.3-1.61.3-0.6-0.6-0.8-0.40.4-0.5-2.1-0.9-0.1-1.0-0.7-1.8
Locomotion in novel chamber0.20.20.80.9-0.20.30.30.10.6-0.60.00.1-0.3-0.30.00.20.8
Locomotion in novel chamber post-restriction0.30.41.21.0-1.00.60.60.30.3-0.30.31.10.80.10.10.10.6
Fecal boli incidents, locomotor time 12.93.26.8-1.71.4-1.8-1.8-1.3-2.02.0-1.4-1.4-0.81.4-2.6-2.5-2.0
Change in fecal boli incidents, locomotor task0.10.10.60.6-0.1-0.0-0.00.30.4-0.40.10.20.30.0-0.00.8-0.2
Time >=10cm from walls, locomotor time 11.41.43.0-1.31.2-1.4-1.4-1.1-1.41.4-1.2-0.9-1.10.60.0-1.7-0.4
Bouts of movement, locomotor time 10.30.40.90.30.4-0.9-0.9-0.4-0.20.2-0.80.2-0.90.30.1-0.40.9
Total resting periods, locomotor time 10.40.41.00.10.5-1.0-1.0-0.5-0.40.4-0.80.1-1.00.3-0.2-0.80.7
Rest time, locomotor task time 10.30.31.70.50.1-0.1-0.10.40.3-0.30.3-0.3-0.9-0.5-0.9-1.3-0.4
Distance moved, locomotor task time 10.50.61.90.1-0.7-0.3-0.3-0.6-0.60.6-0.51.41.21.10.50.90.7
Vertical activity count, locomotor time 10.50.51.80.1-0.5-0.4-0.4-0.7-0.50.5-0.61.30.81.00.51.00.9
Time >=10cm from walls, locomotor time 21.71.84.0-1.51.4-1.4-1.4-1.5-0.90.9-1.4-0.1-1.00.62.01.31.8
Bouts of movement, locomotor time 20.70.82.30.40.50.70.70.41.3-1.30.4-0.7-1.3-1.50.40.51.1
Total resting periods, locomotor time 20.90.92.80.50.30.80.80.61.4-1.40.6-0.7-1.4-1.70.40.21.2
Rest time, locomotor task time 21.31.55.01.0-0.81.21.21.61.0-1.01.5-0.4-0.4-1.4-0.9-2.2-1.0
Distance moved, locomotor task time 21.01.24.7-0.50.3-1.0-1.0-1.2-0.70.7-1.01.0-0.20.81.71.12.2
Vertical activity count, locomotor time 21.21.44.9-0.1-0.2-1.1-1.1-1.0-0.90.9-1.01.90.41.31.01.22.2
Light reinforcement 10.40.73.60.21.0-0.5-0.50.10.5-0.5-0.1-1.6-1.9-0.9-0.5-1.0-0.3
Light reinforcement 20.81.13.60.30.21.01.00.91.4-1.40.9-1.2-1.2-1.90.6-0.40.3
Bone: marrow area1.63.57.9-2.82.1-1.9-1.9-1.6-1.91.9-1.1-2.7-1.40.5-0.1-2.4-1.8
Bone: maximum diameter2.24.18.3-2.91.9-2.4-2.4-2.3-2.72.7-2.3-1.1-1.02.1-0.8-0.9-0.3
Bone: maximum force0.81.45.60.0-0.9-0.1-0.10.5-0.90.90.70.51.01.0-2.4-2.3-1.8
Bone: maximum moment0.81.45.6-0.5-0.6-0.4-0.40.3-1.21.20.40.10.71.0-2.3-2.4-1.9
Mean time between licks in bursts1.52.110.2-2.02.1-0.6-0.6-0.7-0.10.1-0.4-3.2-2.3-1.0-0.5-0.9-1.4
Mean num. licks in bursts1.11.33.4-0.5-0.1-0.9-0.9-0.4-1.61.6-0.60.20.91.8-1.6-1.2-1.4
Cd content in liver3.43.78.91.3-2.32.82.82.51.7-1.73.01.12.3-1.4-0.3-0.2-0.4
Co content in liver0.20.30.70.2-0.80.60.60.3-0.30.30.10.70.60.4-0.9-0.5-0.7
Cu content in liver0.91.03.40.20.40.80.80.81.3-1.30.8-1.3-1.4-1.8-0.4-0.8-0.8
Fe content in liver0.20.31.1-0.40.8-0.4-0.4-0.5-0.10.1-0.7-0.8-1.0-0.30.4-0.0-0.0
K content in liver1.11.15.30.9-1.50.60.60.7-0.20.20.42.31.81.0-0.30.80.6
Mg content in liver1.91.94.31.5-2.11.61.61.70.8-0.81.42.11.8-0.0-0.20.70.5
Mn content in liver1.41.68.6-0.60.6-0.3-0.3-0.9-0.20.2-1.10.7-0.20.42.12.42.9
Na content in liver0.40.41.9-0.0-0.80.40.40.3-0.20.20.21.41.20.50.20.70.7
Rb content in liver1.01.22.90.9-0.71.41.41.31.5-1.51.10.2-0.6-1.70.7-0.21.0
Se content in liver0.40.51.20.4-0.81.11.10.90.7-0.70.90.30.5-0.7-0.50.1-0.3
Sr content in liver0.70.61.0-0.80.9-1.0-1.0-0.9-0.80.8-1.0-0.4-0.31.0-0.20.8-0.3
Zn content in liver2.42.75.31.7-2.02.22.22.31.7-1.72.11.11.1-1.4-0.1-0.3-0.3
Bone: minimum diameter0.40.83.0-1.10.7-0.2-0.20.0-0.20.20.0-1.6-1.1-0.6-0.6-1.7-1.2
Time in familiar zone, hab. session 10.50.51.6-1.20.6-0.4-0.4-0.4-0.70.7-0.2-0.9-0.40.2-0.6-0.8-1.3
Time in novel zone, hab. session 10.90.92.7-0.51.2-0.3-0.3-0.70.5-0.5-0.7-0.9-1.1-0.61.31.51.7
Total zone transitions, hab. session 11.01.46.90.5-0.90.10.11.3-0.20.21.00.00.10.2-2.1-2.6-2.2
Total locomotion distance, hab. session 10.71.04.7-0.3-0.0-1.0-1.0-0.1-1.21.2-0.20.2-0.11.1-1.3-2.2-1.1
Locomotion velocity, hab. session 10.71.06.0-0.1-0.3-0.9-0.90.2-1.21.20.00.40.00.9-0.9-2.4-1.0
Time in familiar zone, hab. session 20.30.30.9-0.30.2-0.3-0.3-0.7-0.40.4-0.50.20.50.70.40.90.6
Time in novel zone, hab. session 20.50.51.20.3-0.40.70.71.10.7-0.70.9-0.4-0.3-0.9-0.3-0.9-0.9
Total zone transitions, hab. session 22.63.46.9-1.50.8-1.8-1.8-1.0-2.32.3-1.2-1.0-0.51.9-2.6-2.6-2.6
Total locomotion distance, hab. session 23.64.88.6-2.31.6-2.7-2.7-2.0-2.92.9-2.1-1.1-1.22.3-1.7-2.4-1.5
Locomotion velocity, hab. session 23.85.19.2-2.51.7-2.8-2.8-2.0-3.03.0-2.2-1.1-1.32.2-1.6-2.5-1.4
Novel to familiar place preference ratio1.01.04.70.3-0.00.80.80.21.1-1.10.5-0.3-0.8-1.62.20.11.6
Novelty place preference0.90.93.80.10.30.50.50.01.0-1.00.3-0.7-1.2-1.62.0-0.11.4
Time in novel zone, NPP test1.11.14.40.10.40.50.50.11.1-1.10.3-0.9-1.4-1.82.1-0.01.3
Total zone transitions, NPP test0.91.33.4-0.6-0.1-0.9-0.9-0.3-1.61.6-0.60.30.21.5-1.8-1.8-1.3
Total locomotion distance, NPP test0.81.22.7-0.8-0.0-0.9-0.9-0.6-1.61.6-0.50.20.51.6-1.4-1.5-0.9
Locomotion velocity, NPP test0.81.12.4-0.6-0.1-0.8-0.8-0.6-1.51.5-0.40.40.61.5-1.5-1.6-0.8
Intraocular pressure1.62.26.60.80.71.01.01.02.2-2.20.8-2.0-1.9-2.61.10.80.0
Delta distance traveled before/after self-admin0.60.61.21.1-0.81.01.00.61.0-1.00.80.40.3-0.6-1.1-0.0-0.1
Delta ambulatory time before/after self-admin0.50.61.61.1-0.80.90.90.50.8-0.80.70.70.5-0.3-1.30.10.1
Parametrial fat weight0.10.20.7-0.30.4-0.1-0.1-0.5-0.30.3-0.1-0.4-0.5-0.1-0.7-0.9-0.5
Pavlov. Cond. lever latency0.81.02.90.20.30.80.80.51.4-1.40.7-0.8-0.7-1.71.40.70.9
Pavlov. Cond. magazine entry latency0.40.51.60.10.30.40.40.30.5-0.50.4-1.2-0.6-0.7-1.0-0.8-1.3
Pavlov. Cond. change in total contacts0.30.30.80.50.5-0.1-0.10.00.5-0.5-0.1-0.7-0.9-0.5-0.7-0.2-0.8
Pavlov. Cond. index score0.20.31.4-0.10.1-0.3-0.3-0.2-0.40.5-0.3-0.2-0.10.5-1.2-0.6-0.9
Pavlov. Cond. latency score0.40.52.0-0.1-0.2-0.4-0.4-0.2-0.80.8-0.30.30.41.0-1.4-0.8-1.1
Pavlov. Cond. lever contacts0.60.72.7-0.0-0.5-0.3-0.3-0.1-1.01.0-0.30.60.81.3-1.6-0.7-1.2
Pavlov. Cond. magazine entry number0.40.51.10.4-0.80.60.60.40.4-0.40.41.10.9-0.10.90.81.0
Pavlov. Cond. intertrial magazine entries0.10.10.40.3-0.30.10.10.2-0.00.00.20.00.50.10.00.1-0.6
Pavlov. Cond. lever-magazine prob. diff.0.10.20.8-0.10.3-0.2-0.2-0.2-0.10.1-0.2-0.6-0.40.0-0.9-0.4-0.8
Pavlov. Cond. response bias0.30.42.00.20.2-0.2-0.2-0.1-0.20.2-0.1-0.5-0.30.2-1.4-0.8-1.4
Pavlov. Cond. lever latency5.16.915.0-3.73.9-3.0-3.0-3.2-2.22.2-3.1-3.2-3.00.90.4-0.6-0.0
Pavlov. Cond. magazine entry latency2.12.45.22.3-2.21.71.71.81.2-1.22.01.51.6-0.6-0.8-0.7-1.0
Pavlov. Cond. change in total contacts5.37.315.93.9-4.03.13.13.42.1-2.13.42.73.0-0.9-1.3-0.5-1.1
Pavlov. Cond. index score4.05.111.13.3-3.22.62.62.72.0-2.02.92.42.4-1.1-0.7-0.1-0.5
Pavlov. Cond. latency score3.84.710.23.2-3.22.52.52.51.8-1.82.72.52.5-0.8-0.60.0-0.3
Pavlov. Cond. lever contacts4.56.114.53.8-3.52.82.82.92.2-2.22.83.02.5-1.0-0.20.70.4
Pavlov. Cond. magazine entry number4.55.511.1-3.33.2-2.8-2.8-2.9-2.32.3-3.1-2.0-2.21.41.00.31.1
Pavlov. Cond. intertrial magazine entries0.50.61.8-1.41.3-0.5-0.5-0.8-0.30.3-0.9-1.2-1.0-0.00.20.70.4
Pavlov. Cond. lever-magazine prob. diff.4.15.311.33.4-3.22.62.62.92.1-2.13.02.32.3-1.2-0.8-0.4-0.6
Pavlov. Cond. response bias6.08.219.04.4-4.03.33.33.62.7-2.73.53.02.7-1.4-0.70.3-0.2
Time in closed arm before self-admin0.40.41.50.20.60.40.40.30.8-0.80.0-1.0-1.2-1.00.6-0.00.3
Time in closed arm after self-admin1.41.45.7-1.01.8-0.4-0.4-0.60.5-0.5-0.5-2.2-2.4-1.21.20.20.4
Time in open arm before self-admin0.30.32.10.30.2-0.4-0.4-0.30.1-0.1-0.40.1-0.10.20.41.01.5
Time in open arm after self-admin0.70.83.30.3-1.30.30.30.3-0.50.50.21.81.70.8-0.3-0.00.9
Bone: periosteal estimation0.81.84.5-2.11.1-1.2-1.2-0.9-1.61.6-0.6-1.6-0.70.6-0.5-2.0-1.4
Bone: periosteal perimeter1.42.34.7-2.21.3-1.9-1.9-1.2-2.12.1-1.3-1.0-1.11.3-0.3-1.6-0.3
Bone: post-yield work0.20.31.30.2-0.50.20.20.3-0.10.10.6-0.00.70.2-0.9-0.9-1.1
Progressive ratio test 1 active lever presses1.31.45.70.4-0.8-0.5-0.5-0.2-1.01.0-0.30.91.01.0-2.4-1.8-2.0
Progressive ratio test 1 breakpoint1.31.35.50.5-0.7-0.6-0.6-0.3-1.01.0-0.40.91.01.1-2.4-1.7-1.9
Progressive ratio test 1 inactive lever presses1.51.73.1-0.91.2-1.5-1.5-1.1-1.41.4-1.4-1.1-1.00.8-0.9-1.8-1.7
Progressive ratio test 2 active lever presses0.40.42.1-0.90.8-0.2-0.20.1-0.10.1-0.1-1.5-1.0-0.50.4-0.8-0.7
Progressive ratio test 2 breakpoint0.40.41.9-0.80.7-0.0-0.00.20.2-0.20.1-1.4-0.9-0.70.6-0.6-0.5
Progressive ratio test 2 inactive lever presses1.72.03.7-1.21.9-1.9-1.9-1.5-0.90.9-1.9-1.7-1.70.51.4-0.1-0.0
Incentive Sensitization - Responses1.41.55.2-1.51.8-0.6-0.6-0.20.3-0.3-0.5-2.3-2.1-0.91.70.30.5
Incentive Sensitization - Breakpoint1.41.44.9-1.51.7-0.4-0.4-0.10.4-0.4-0.3-2.2-2.0-1.01.90.40.7
Sum of active levers in priming session hrs 5-63.23.16.1-0.92.3-2.1-2.1-2.5-1.00.9-2.3-1.0-2.21.1-0.61.22.4
Progressive ratio1.21.43.8-1.91.7-1.4-1.4-1.1-1.21.2-1.3-1.1-1.10.60.60.30.3
Food seeking constrained by brief footshock1.21.42.6-1.51.4-1.6-1.6-1.3-1.31.3-1.4-0.8-1.31.0-0.3-0.6-0.0
Seeking ratio, punishment vs. effort0.30.40.90.9-0.90.80.80.60.5-0.50.70.60.3-0.3-0.3-0.60.2
Retroperitoneal fat weight1.34.46.4-2.52.1-2.2-2.2-2.1-2.32.3-1.6-2.1-1.71.1-1.9-2.4-2.2
Reaction time number correct0.50.71.70.6-0.91.01.01.30.8-0.80.90.60.9-0.5-1.00.6-0.7
Reaction time mean minus median0.60.71.60.9-0.11.11.10.41.3-1.31.0-0.8-0.2-1.30.10.3-0.5
Reaction time mean minus median AUC1.21.53.11.4-1.11.81.81.11.6-1.61.70.20.6-1.40.80.40.2
Reaction time num false alarms0.91.23.31.1-1.81.21.21.10.4-0.41.31.71.80.1-0.8-0.30.2
Reaction time num false alarms AUC0.91.33.61.2-1.81.11.11.10.4-0.41.31.81.90.1-0.6-0.10.1
Reaction time trials correct on left0.50.71.70.6-0.91.01.01.30.8-0.80.90.60.9-0.5-1.00.6-0.7
Reaction time trials on left0.50.71.70.6-0.81.01.01.30.9-0.90.90.50.8-0.5-1.00.6-0.7
Reaction time mean0.91.22.41.3-0.51.51.50.61.5-1.51.2-0.60.2-1.51.0-0.00.0
Reaction time mean AUC1.01.32.71.5-0.81.61.60.71.6-1.61.3-0.20.5-1.41.00.20.3
Median of all reaction times0.81.12.21.2-0.61.51.50.71.4-1.41.1-0.40.3-1.41.4-0.10.3
Reaction time omissions1.01.33.21.1-0.21.41.40.91.8-1.81.2-0.7-0.0-1.50.61.20.2
Reaction time false alarm rate0.20.31.10.6-0.90.40.40.3-0.00.00.51.00.70.10.4-0.40.9
Reaction time premature initiation rate0.70.92.7-0.20.3-0.5-0.5-1.5-0.50.5-1.10.70.71.01.01.61.5
Reaction time premature initiations0.50.73.6-0.0-0.2-0.0-0.0-0.8-0.20.2-0.61.21.30.90.21.91.2
Std. dev. reaction times0.81.12.41.3-0.31.31.30.51.6-1.61.2-1.0-0.2-1.50.50.1-0.4
Reaction time trials completed0.50.71.70.6-0.81.01.01.30.9-0.90.90.50.8-0.5-1.00.6-0.7
Reaction time trials AUC0.50.71.70.4-0.80.90.91.30.8-0.80.90.40.8-0.5-1.10.4-0.8
Run reversals in cocaine runway, females1.11.13.90.9-1.11.21.20.90.8-0.81.20.10.9-0.6-1.0-0.7-2.0
Run reversals in cocaine runway, males0.60.52.3-0.50.60.40.4-0.30.4-0.4-0.1-0.7-1.0-0.71.50.41.4
Latency to leave start box in cocaine runway0.50.52.4-1.10.8-0.0-0.00.1-0.10.10.1-1.5-0.7-0.50.7-0.5-1.3
Latency to leave start box in cocaine runway, F0.30.31.5-0.3-0.10.20.20.80.0-0.00.7-0.4-0.1-0.4-0.1-0.9-1.2
Latency to leave start box in cocaine runway, M1.01.03.2-1.31.6-0.6-0.6-1.0-0.30.3-0.9-1.8-1.4-0.21.20.3-0.1
Std. dev. time between licks in bursts0.91.12.60.6-0.41.21.21.11.5-1.51.3-0.2-0.2-1.61.00.50.8
Total sessions with >9 infusions0.10.10.40.40.2-0.1-0.10.10.1-0.1-0.2-0.0-0.3-0.0-0.70.60.3
Short access day 1 total inactive lever presses2.22.55.0-1.71.6-2.0-2.0-1.9-2.02.0-2.2-0.4-0.51.8-0.80.50.3
Short access day 10 total inactive lever presses0.40.51.70.9-0.90.40.40.80.1-0.10.51.31.10.3-0.30.40.6
Short access day 1 total infusions0.30.30.8-0.40.8-0.5-0.5-0.3-0.20.2-0.5-0.8-0.9-0.1-0.4-0.3-0.4
Short access day 10 total infusions0.20.20.40.5-0.40.50.50.50.5-0.50.40.30.2-0.4-0.40.60.1
Short access total infusions0.10.10.90.10.10.00.00.20.1-0.1-0.0-0.2-0.3-0.3-0.9-0.1-0.4
Short access day 1 locomotion0.50.61.10.60.30.60.60.71.0-1.00.3-0.6-0.7-1.00.80.90.7
Short access day 10 total locomotion2.52.85.90.7-1.62.42.42.21.7-1.72.10.71.5-1.41.01.80.9
Short access total locomotion0.70.71.40.6-0.81.21.21.00.9-0.90.90.60.7-0.6-0.21.20.7
One hour access (0.3 mA shock)0.70.82.4-0.20.20.90.90.31.0-1.00.5-0.6-0.1-1.01.21.31.6
Compulsive drug intake0.60.62.5-0.90.50.90.90.30.5-0.50.8-1.6-0.6-1.10.5-0.6-0.5
One hour access (shock baseline)0.40.52.70.2-0.10.10.10.00.5-0.5-0.20.60.2-0.20.71.61.6
Social response proportion0.50.62.5-1.01.0-0.2-0.2-0.3-0.20.2-0.4-1.5-1.6-0.60.6-0.30.2
Social responses0.30.41.81.0-0.5-0.1-0.10.50.0-0.00.20.5-0.40.0-1.3-1.2-0.5
Social time0.20.31.60.0-0.30.30.30.0-0.10.1-0.00.20.70.21.31.10.2
Soleus weight5.215.134.1-4.45.8-4.7-4.7-5.3-2.52.5-5.0-4.0-4.71.11.41.42.1
Bone: stiffness0.50.84.30.2-0.6-0.2-0.20.1-0.60.60.30.30.60.8-2.1-1.7-1.3
Tibialis anterior weight2.37.814.4-3.33.0-3.4-3.4-3.8-3.53.5-3.7-1.1-1.62.90.70.41.1
Time to tail flick, vehicle, before self-admin1.51.54.91.0-1.2-0.6-0.6-0.1-1.01.0-0.41.51.51.7-2.2-1.3-1.5
Time to tail flick, vehicle, after self-admin0.40.41.0-0.60.8-0.9-0.9-0.4-0.60.6-1.0-0.2-0.40.60.20.4-0.1
Time to tail flick, test, before self-admin1.00.92.5-0.10.6-1.3-1.3-1.2-0.80.8-1.50.2-0.41.10.60.51.6
Time to tail flick, test, after self-admin0.20.31.0-0.40.6-0.1-0.1-0.20.2-0.2-0.5-0.9-0.6-0.31.00.4-0.4
Delta time to tail flick, vehicle, before/after SA1.31.33.2-1.71.8-0.7-0.7-0.6-0.10.1-0.8-1.2-1.4-0.41.61.31.4
Delta time to tail flick, test, before/after SA0.40.41.9-1.10.8-0.1-0.1-0.2-0.20.2-0.2-1.1-0.5-0.30.3-0.1-1.4
Tibia length0.10.31.0-0.90.7-0.3-0.3-0.50.2-0.2-0.5-0.8-0.4-0.3-0.01.0-0.1
Ambulatory time before self-admin1.21.33.5-0.8-0.0-1.2-1.2-1.0-1.71.7-1.20.71.11.90.0-0.4-0.8
Ambulatory time after self-admin0.20.31.10.5-0.80.30.30.1-0.10.10.10.81.10.5-0.5-0.3-0.5
Bone: tissue strength2.22.15.7-0.8-0.3-1.0-1.0-0.5-1.91.9-0.70.60.72.0-2.4-2.1-2.0
Total heroin consumption0.50.62.50.40.70.30.30.50.8-0.80.6-1.3-1.6-1.10.2-0.20.3
Bone: trabecular number1.72.66.0-1.40.9-1.9-1.9-1.9-2.42.4-1.50.10.42.4-1.5-0.7-0.3
Bone: trabecular spacing0.70.92.60.4-0.21.11.10.81.3-1.30.7-0.8-0.8-1.60.6-0.3-0.7
Bone: trabecular thickness0.30.31.2-0.1-0.3-0.1-0.1-0.1-0.50.50.10.41.00.8-1.1-0.1-0.6
Bone: trabecular tissue density1.21.63.81.9-1.51.51.51.51.5-1.51.50.90.9-0.80.10.7-0.4
Water consumed over 24 hours0.30.41.00.9-0.40.40.41.00.8-0.80.9-0.2-0.3-0.80.3-0.7-0.2
Number of responses in last shaping day1.51.55.31.2-1.91.21.21.00.6-0.61.12.31.80.0-1.20.30.5