Hub : Genes

Isyna1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Isyna1 0.05 0.04 6.5e-03 0.06 0.03 0.03 0.04 7.2e-04 1.1e-02 6.3e-03 2.0e-03
2 IC gene expression Isyna1 0.13 0.12 8.0e-03 0.07 0.03 0.06 0.06 1.0e-03 1.4e-02 1.1e-03 1.8e-03
3 Liver mRNA stability Isyna1 0.03 0.02 8.0e-06 0.03 0.04 0.03 0.04 1.3e-04 1.4e-05 3.5e-04 5.3e-05
4 NAcc gene expression Isyna1 0.03 0.02 2.2e-03 0 0.01 0 0 1.3e-01 2.6e-02 7.9e-02 1.1e-01
5 pVTA gene expression Isyna1 0.03 0.03 4.3e-03 0.04 0.02 0.02 0.03 4.4e-04 9.4e-03 1.3e-02 2.5e-03
6 Adipose gene expression Isyna1 0.52 0.11 0.0e+00 0.29 0.33 0.32 0.32 3.2e-32 9.7e-38 6.7e-36 6.1e-36
7 PL gene expression Isyna1 0.06 0.04 7.5e-05 0.04 0.04 0.04 0.04 5.4e-05 2.6e-05 2.1e-05 1.1e-05
8 Liver gene expression Isyna1 0.84 0.04 0.0e+00 0.42 0.54 0.56 0.56 6.9e-51 1.1e-71 6.4e-76 1.9e-75
9 Brain gene expression Isyna1 0.42 0.13 5.1e-08 0.03 0.07 0.07 0.07 5.4e-04 4.6e-07 4.9e-07 7.2e-07
10 Adipose mRNA stability Isyna1 0.05 0.04 3.7e-04 0.02 0.01 0.01 0.01 9.7e-04 3.1e-02 7.3e-03 7.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density0.91.66.92.42.6-0.70.00.50.71.10.2-0.21.1
Area under the delay curve0.50.53.5-0.6-0.30.30.2-0.20.0-0.20.8-1.90.8
BMI with tail1.34.69.22.32.7-2.8-3.02.3-2.11.8-1.50.3-1.1
BMI without tail2.57.713.23.03.1-3.5-3.63.0-2.92.4-2.51.0-1.7
Body weight3.917.231.35.35.6-5.2-5.14.5-3.74.1-2.70.8-0.9
Weight adjusted by age1.92.93.91.31.8-1.9-1.81.8-1.51.5-2.01.9-1.5
Bone surface0.61.04.61.92.2-0.6-0.20.30.60.50.5-0.50.7
Bone volume1.11.98.02.62.8-1.2-0.60.90.21.1-0.20.20.4
Breakpoint value in progressive ratio session0.10.10.50.10.2-0.2-0.50.0-0.3-0.2-0.10.0-0.7
Number of licking bursts0.71.24.6-0.6-0.60.50.2-0.20.2-0.21.4-2.11.9
Context. condit. distance diff. score0.40.51.5-1.1-1.20.30.10.00.10.50.4-0.31.2
Locomotion velocity, session 10.50.61.2-0.9-0.90.1-0.9-0.40.1-1.10.9-0.9-0.3
Locomotion distance, session 11.72.24.2-1.3-1.11.40.9-1.71.7-1.62.1-1.51.1
Locomotion velocity, session 21.11.34.90.30.3-1.5-2.21.2-1.60.6-0.6-0.4-0.6
Locomotion distance, session 22.02.84.5-1.3-1.21.71.2-2.02.1-2.02.1-1.60.9
Locomotion velocity, session 30.80.94.0-1.9-2.00.70.0-0.60.1-0.60.4-0.40.1
Locomotion distance, session 30.60.61.8-0.4-0.20.91.0-1.01.3-0.50.90.20.7
Stereotopy head waving bouts, day 32.22.66.5-2.0-2.11.20.6-0.70.50.01.8-2.32.6
Stereotopy head waving duration, day 31.21.43.5-1.6-1.70.6-0.1-0.1-0.10.31.1-1.81.9
Locomotion velocity, session 70.91.01.9-1.4-1.31.10.9-1.30.9-1.20.60.0-0.3
Locomotion distance, session 71.11.42.3-0.9-0.81.41.5-1.41.3-1.31.2-1.00.5
Stereotopy head waving bouts, day 70.20.20.8-0.3-0.2-0.1-0.50.3-0.00.60.3-0.20.9
Stereotopy head waving duration, day 70.40.51.5-0.3-0.3-0.7-1.20.9-0.91.0-0.40.20.3
Locomotion velocity, session 82.12.68.6-2.9-2.81.2-0.0-1.30.7-1.31.4-1.20.5
Locomotion distance, session 81.01.52.8-1.2-1.21.10.5-1.21.4-1.01.7-1.31.2
Degree of sensitization distance0.20.20.5-0.6-0.70.50.4-0.3-0.1-0.70.1-0.7-0.2
Degree of sensitization stereotypy0.30.30.60.50.6-0.6-0.70.6-0.20.8-0.20.60.3
Conditioned locomotion0.20.20.70.80.10.30.50.10.20.20.4-0.30.9
Cocaine response after cond. corrected0.20.30.90.2-0.20.20.80.3-0.30.9-0.70.60.3
Cocaine response after cond. not corrected0.20.31.1-0.5-1.10.60.8-0.3-0.00.2-0.30.10.1
Cocaine response before conditioning1.01.23.2-1.5-1.40.7-0.2-1.20.5-1.81.1-1.2-0.4
Saline control response0.10.10.50.0-0.20.20.0-0.50.7-0.60.30.3-0.3
Bone: connectivity density0.81.25.62.22.4-0.70.10.40.60.70.20.10.6
Bone: cortical apparent density0.20.31.10.40.20.10.1-0.90.5-1.10.0-0.1-0.9
Bone: cortical area5.88.816.33.94.0-3.3-2.83.2-2.13.1-2.72.4-1.2
Bone: cortical porosity0.10.10.40.10.30.1-0.3-0.40.3-0.60.6-0.5-0.1
Bone: cortical porosity0.20.20.60.10.30.1-0.2-0.40.4-0.60.8-0.80.3
Bone: cortical thickness3.35.511.13.33.3-2.5-2.12.5-1.22.8-1.81.8-0.2
Bone: cortical thickness1.51.85.51.71.6-0.9-0.41.30.12.3-0.00.22.0
Bone: cortical tissue density0.30.41.40.20.00.20.2-1.00.5-1.20.2-0.2-0.8
Condit. Reinf. active minus inactive responses0.60.73.00.80.9-0.3-0.20.50.31.00.7-0.71.7
Condit. Reinf. active-inactive response ratio0.70.82.51.21.3-0.20.40.30.61.10.40.11.6
Condit. Reinf. active responses0.60.72.40.70.8-0.6-0.70.6-0.11.00.7-1.01.5
Condit. Reinf. inactive responses0.30.41.20.30.3-0.8-1.10.6-0.90.2-0.4-0.2-0.6
Incentive salience index mean0.91.02.61.01.0-0.7-1.10.6-0.10.71.0-1.51.6
Condit. Reinf. lever presses1.01.44.50.90.9-1.0-1.90.6-0.40.31.2-2.11.3
Condit. Reinf. active minus inactive responses0.10.20.3-0.2-0.50.40.3-0.40.6-0.60.10.6-0.5
Condit. Reinf. active-inactive response ratio0.40.40.80.90.3-0.6-0.60.8-0.50.6-0.70.7-0.4
Condit. Reinf. active responses0.81.12.5-1.2-1.61.10.7-1.31.0-1.60.60.2-0.6
Condit. Reinf. inactive responses1.92.45.1-2.2-2.31.61.1-1.91.0-2.20.70.1-0.9
Condit. Reinf. lever presses0.20.31.10.1-0.4-0.4-0.90.1-0.8-0.3-0.60.2-1.1
Condit. Reinf. lever reinforcers received0.30.40.9-0.6-0.90.40.2-0.60.3-1.0-0.10.5-0.9
Conditioned reinforcement - actives1.42.33.21.81.6-1.6-1.21.7-1.51.3-1.71.6-1.0
Conditioned reinforcement - inactives6.910.114.73.53.1-3.4-2.53.6-3.23.8-3.53.1-1.4
Conditioned locomotion1.31.72.61.51.0-1.4-1.11.6-1.51.3-1.51.0-0.7
Patch foraging indifference point 0 sec1.83.47.72.01.1-2.2-2.82.1-2.51.8-1.0-0.9-0.1
Patch foraging indifference point AUC0.30.42.7-0.2-0.50.0-0.4-0.2-0.4-0.70.4-1.7-0.1
Delay disc. indifference point, 0s delay3.53.89.7-2.2-2.21.81.1-1.61.2-1.72.3-3.11.5
Delay disc. indifference point, 16s delay0.80.92.8-1.0-1.00.90.8-0.70.2-1.10.8-1.70.5
Delay disc. indifference point, 2s delay1.41.55.1-1.1-0.71.00.6-1.00.9-0.61.7-2.31.4
Delay disc. indifference point, 24s delay0.30.41.3-0.3-0.5-0.4-0.70.6-1.00.2-0.1-1.10.1
Delay disc. indifference point, 4s delay0.40.42.1-0.6-0.00.1-0.3-0.40.3-0.40.8-1.40.4
Delay disc. indifference point, 8s delay0.30.31.5-0.20.0-0.3-0.30.5-0.80.5-0.1-1.20.2
Indifference point function ln k0.50.91.61.11.3-0.9-0.41.2-0.41.2-0.81.2-0.0
Indifference point function log k0.50.91.61.11.3-0.9-0.41.2-0.41.2-0.81.2-0.0
Patch foraging total patch changes 0 sec2.85.210.72.71.6-2.8-3.32.7-3.02.2-1.5-0.8-0.2
Patch foraging total patch changes 12 sec0.70.92.60.3-0.3-1.0-1.60.8-1.50.6-0.4-1.40.1
Patch foraging total patch changes 18 sec0.10.20.9-0.0-0.70.1-0.30.1-0.6-0.40.1-0.9-0.3
Patch foraging total patch changes 24 sec0.30.40.70.60.4-0.6-0.80.8-0.80.8-0.1-0.90.4
Patch foraging total patch changes 6 sec1.21.96.40.70.0-1.6-2.51.2-2.11.0-0.6-1.6-0.1
Patch foraging time to switch 0 sec0.81.73.6-1.9-1.31.41.0-1.71.3-1.81.0-0.5-0.2
Patch foraging water rate 0 sec0.81.83.71.91.3-1.5-1.81.4-1.31.4-0.3-1.00.7
Patch foraging water rate 12 sec0.40.93.61.91.6-0.8-0.60.9-0.30.9-0.30.20.3
Patch foraging water rate 18 sec0.50.72.20.61.00.20.1-0.50.8-0.41.2-1.51.1
Patch foraging water rate 24 sec0.50.82.81.11.7-0.6-0.60.30.40.40.8-0.81.1
Patch foraging water rate 6 sec1.11.52.81.71.5-1.4-1.21.5-1.21.5-0.80.40.2
Seeking ratio, delayed vs. immediate footshock0.91.23.0-1.5-1.70.80.2-1.10.8-1.50.9-0.9-0.2
Distance traveled before self-admin0.60.82.90.20.2-1.2-1.70.9-1.30.6-0.80.0-0.7
Distance traveled after self-admin1.01.23.20.80.7-1.4-1.81.0-1.31.0-1.00.7-0.9
Extensor digitorum longus weight0.20.83.40.1-0.1-1.1-1.81.0-1.20.7-0.2-0.80.2
Bone: elastic displacement0.30.40.9-0.4-0.40.50.3-0.81.0-0.60.9-0.40.4
Bone: elastic work1.21.62.51.61.6-1.6-1.51.5-1.01.4-1.00.6-0.3
Bone: endosteal estimation0.10.30.60.70.7-0.6-0.40.8-0.80.2-0.4-0.3-0.3
Bone: endosteal perimeter1.12.43.51.61.7-1.6-1.21.9-1.61.6-1.71.6-0.9
Epididymis fat weight0.93.18.82.53.0-2.1-2.01.2-1.00.5-1.20.8-1.6
Delta time in closed arm before/after self-admin0.30.32.20.20.1-0.2-0.20.0-0.5-0.10.3-1.50.5
Delta time in open arm before/after self-admin0.60.61.7-0.5-0.10.70.7-1.30.9-1.30.50.1-0.3
Diff in mean of infusions in LGA sessions1.41.64.50.30.2-1.5-2.11.1-1.90.3-1.40.3-1.6
Delay discount exponential model param0.30.32.20.30.1-0.10.0-0.00.2-0.2-0.51.5-0.7
Extinction: sum of active levers before priming0.70.81.6-0.10.10.60.4-1.11.2-1.31.2-1.20.2
Active lever presses in extinction session 60.20.20.7-0.7-0.60.30.1-0.50.3-0.80.10.1-0.4
Bone: final force6.09.515.43.93.8-3.7-3.53.7-2.93.3-2.30.7-0.3
Bone: final moment5.79.114.73.83.7-3.5-3.33.7-2.93.3-2.40.9-0.3
Food consumed during 24 hour testing period0.60.81.90.1-0.10.80.5-0.91.2-0.91.4-1.10.9
Glucose1.42.24.11.11.3-1.8-2.01.7-1.81.5-1.40.7-1.1
Heart weight0.91.34.91.00.8-1.1-0.91.4-0.52.2-0.61.10.9
Delay discount hyperbolic model param0.40.42.80.50.1-0.10.10.00.1-0.2-0.71.7-0.8
Intermittent access intake day 1-15 change0.40.83.31.11.3-0.40.20.50.20.8-0.71.8-0.4
Intermittent access intake escalation0.30.62.40.91.1-0.10.50.10.50.5-0.41.5-0.2
Intermittent access intake escalation 20.70.92.21.31.5-0.8-0.40.6-0.30.5-0.91.3-0.9
Intermitt. access day 1 inactive lever presses0.31.15.60.20.3-0.6-0.40.6-0.51.0-1.42.4-1.2
Intermitt. access day 15 inactive lever presses0.30.63.5-0.2-0.40.10.40.3-0.10.9-0.71.9-0.5
Intermitt. access escalation Index0.81.13.0-0.9-0.81.00.9-0.80.9-0.71.3-1.71.2
Intermittent access day 1 total infusions0.71.23.60.60.2-1.1-1.11.4-1.91.1-1.40.4-0.7
Intermittent access day 15 total infusions0.50.81.81.31.1-0.50.10.8-0.41.0-0.91.2-0.3
Intermittent access terminal intake (last 3 days)0.50.72.01.41.1-0.60.00.8-0.60.8-0.80.7-0.3
Intermittent access total infusions1.51.83.01.71.3-1.3-0.81.5-1.61.3-1.61.1-0.8
Intermittent access day 1 locomotion1.92.44.51.51.1-1.7-1.61.8-2.11.3-1.80.7-1.2
Intermittent access day 15 total locomotion0.30.51.61.31.0-0.5-0.10.7-0.60.5-0.60.6-0.3
Intermittent access total locomotion2.02.43.61.91.5-1.7-1.41.7-1.81.3-1.81.1-1.1
Intermittent access standard deviation0.20.40.80.70.6-0.6-0.40.7-0.60.6-0.80.9-0.5
Left kidney weight0.52.15.91.71.2-1.8-2.41.4-1.60.7-1.00.1-1.3
Right kidney weight1.36.112.32.72.7-3.1-3.52.1-2.41.2-2.21.1-2.6
Cocaine induced anxiety1.42.03.80.10.2-1.5-1.91.3-1.91.3-1.71.1-1.5
Post-drug Anxiety0.20.20.5-0.6-0.5-0.2-0.60.2-0.50.3-0.40.3-0.7
Baseline Anxiety2.63.04.6-1.0-1.21.91.9-1.92.1-1.72.1-1.61.4
Tail length0.72.75.12.11.8-2.2-2.31.8-1.61.2-1.20.4-0.7
Length with tail1.66.913.03.63.5-3.3-3.22.7-2.32.3-1.81.0-0.8
Length without tail1.34.210.03.13.2-2.2-1.72.0-1.22.4-1.31.20.1
Times rat made contact with spout0.60.72.80.30.10.50.5-0.50.6-0.61.2-1.71.1
Lifetime Intake2.32.84.21.91.5-1.7-1.32.0-2.01.8-1.91.3-0.9
Liver weight, left0.40.62.2-0.10.10.60.4-1.21.3-1.50.70.1-0.4
Liver weight, right1.93.36.82.62.6-2.0-1.91.1-1.30.4-1.61.4-2.1
Locomotor activity0.50.81.71.11.1-0.1-0.4-0.60.9-0.61.3-1.10.8
Locomotor testing distance0.50.92.10.30.30.60.6-1.01.4-0.81.5-1.01.1
Locomotor testing rearing0.50.92.20.10.00.60.2-1.01.1-1.31.5-1.50.6
Locomotion in novel chamber0.30.41.70.90.8-0.3-0.4-0.10.1-0.20.6-1.30.5
Locomotion in novel chamber post-restriction0.91.43.51.61.90.10.5-0.31.30.11.4-1.31.5
Fecal boli incidents, locomotor time 10.20.20.50.10.40.40.6-0.70.4-0.40.3-0.7-0.2
Change in fecal boli incidents, locomotor task0.40.42.1-0.9-1.50.50.1-0.1-0.2-0.50.4-0.60.2
Time >=10cm from walls, locomotor time 10.20.21.00.4-0.1-0.1-0.2-0.0-0.3-0.4-0.4-0.1-1.0
Bouts of movement, locomotor time 10.30.31.3-0.30.20.40.4-0.90.4-1.10.3-0.3-0.6
Total resting periods, locomotor time 10.60.72.1-0.6-0.00.80.8-1.20.8-1.50.7-0.5-0.3
Rest time, locomotor task time 10.20.20.8-0.9-0.60.30.2-0.3-0.2-0.20.4-0.70.5
Distance moved, locomotor task time 10.10.10.3-0.1-0.50.0-0.00.4-0.1-0.1-0.30.4-0.4
Vertical activity count, locomotor time 10.10.10.20.40.4-0.1-0.2-0.10.4-0.5-0.10.4-0.5
Time >=10cm from walls, locomotor time 20.71.12.3-1.0-1.01.31.5-0.91.4-0.60.8-0.10.9
Bouts of movement, locomotor time 20.10.20.6-0.6-0.80.3-0.0-0.50.0-0.20.4-0.20.3
Total resting periods, locomotor time 20.10.10.5-0.5-0.70.2-0.1-0.4-0.3-0.00.2-0.10.2
Rest time, locomotor task time 20.30.41.50.10.2-0.8-1.00.7-1.20.3-0.5-0.2-0.0
Distance moved, locomotor task time 20.30.41.6-0.3-0.40.50.9-0.10.70.0-0.41.3-0.5
Vertical activity count, locomotor time 20.30.31.4-0.3-0.10.40.7-0.41.00.3-0.11.20.2
Light reinforcement 10.00.10.30.30.1-0.3-0.40.1-0.6-0.1-0.1-0.4-0.1
Light reinforcement 20.30.42.00.0-0.2-0.5-0.60.4-1.40.2-0.9-0.3-0.6
Bone: marrow area0.10.20.50.60.6-0.5-0.30.7-0.70.1-0.3-0.5-0.1
Bone: maximum diameter2.34.46.82.32.4-2.3-1.92.5-1.82.6-2.01.6-0.5
Bone: maximum force5.39.417.84.24.2-3.6-3.53.5-2.53.1-2.10.7-0.4
Bone: maximum moment4.78.315.73.94.0-3.4-3.13.3-2.33.0-2.10.9-0.4
Mean time between licks in bursts1.23.05.21.81.8-2.2-2.31.9-1.91.7-1.50.8-0.6
Mean num. licks in bursts0.30.41.31.11.0-0.10.3-0.00.30.1-0.51.0-0.7
Cd content in liver1.61.74.81.52.2-1.00.11.5-0.32.1-0.80.91.1
Co content in liver0.10.10.9-0.9-0.20.0-0.10.00.00.10.10.10.3
Cu content in liver1.61.94.1-0.7-1.01.51.2-1.41.7-1.12.0-1.21.6
Fe content in liver0.50.61.1-0.1-0.91.01.0-0.90.8-1.00.30.1-0.3
K content in liver2.01.94.3-1.2-2.11.71.4-1.31.1-1.31.4-1.21.0
Mg content in liver0.10.10.5-0.4-0.70.40.4-0.20.3-0.10.20.20.2
Mn content in liver0.20.31.8-0.3-0.4-0.2-0.20.3-0.10.3-0.51.3-0.4
Na content in liver2.42.64.3-1.1-1.51.81.3-2.11.8-2.11.9-1.50.4
Rb content in liver1.51.75.81.50.9-0.9-0.21.7-1.02.4-1.31.20.6
Se content in liver0.20.30.8-0.5-0.50.60.6-0.70.9-0.30.30.5-0.1
Sr content in liver0.40.31.20.00.30.20.4-0.60.4-0.8-0.20.5-1.1
Zn content in liver0.10.20.8-0.2-0.20.0-0.1-0.1-0.0-0.4-0.30.7-0.9
Bone: minimum diameter2.34.28.32.82.9-2.3-2.12.1-1.61.4-1.91.3-1.5
Time in familiar zone, hab. session 10.30.30.60.70.7-0.6-0.50.3-0.5-0.0-0.50.4-0.8
Time in novel zone, hab. session 10.50.53.0-0.2-0.30.30.5-0.10.50.50.8-0.61.7
Total zone transitions, hab. session 10.60.82.1-0.30.10.70.4-1.11.0-1.31.3-1.40.4
Total locomotion distance, hab. session 11.52.14.4-0.4-0.01.31.0-1.61.8-1.82.1-1.71.0
Locomotion velocity, hab. session 11.21.73.9-0.6-0.21.20.8-1.61.6-2.01.8-1.60.5
Time in familiar zone, hab. session 20.20.20.80.20.1-0.4-0.30.4-0.40.1-0.70.9-0.8
Time in novel zone, hab. session 20.10.10.40.40.30.20.4-0.10.20.20.10.10.6
Total zone transitions, hab. session 20.10.10.3-0.2-0.10.40.5-0.40.6-0.30.20.4-0.0
Total locomotion distance, hab. session 20.40.62.00.00.20.70.7-0.81.4-0.41.0-0.10.9
Locomotion velocity, hab. session 20.50.72.1-0.20.00.80.7-0.91.5-0.71.2-0.40.8
Novel to familiar place preference ratio0.30.41.51.01.2-0.40.10.2-0.40.2-0.60.3-0.5
Novelty place preference0.20.20.90.70.9-0.20.20.2-0.30.2-0.50.3-0.3
Time in novel zone, NPP test0.10.10.60.60.80.00.5-0.1-0.0-0.1-0.20.2-0.2
Total zone transitions, NPP test1.21.83.8-0.7-0.61.20.8-1.31.5-1.12.0-1.91.5
Total locomotion distance, NPP test2.53.47.5-0.9-0.71.71.3-1.82.3-1.52.7-2.32.1
Locomotion velocity, NPP test2.23.16.5-1.0-0.81.61.2-1.82.1-1.62.5-2.41.8
Intraocular pressure1.21.73.71.11.0-1.3-0.91.6-1.41.9-1.51.6-0.2
Delta distance traveled before/after self-admin0.70.81.41.11.2-1.0-1.00.5-0.70.5-0.90.9-0.9
Delta ambulatory time before/after self-admin0.30.30.90.60.7-0.5-0.40.2-0.40.5-0.60.9-0.6
Parametrial fat weight3.07.111.62.62.6-3.1-2.92.8-3.42.0-3.01.5-2.1
Pavlov. Cond. lever latency0.81.05.1-0.3-0.40.21.00.2-0.30.4-1.42.3-1.1
Pavlov. Cond. magazine entry latency0.30.41.30.70.9-0.5-0.70.3-0.30.00.3-1.10.4
Pavlov. Cond. change in total contacts1.51.65.60.80.8-1.0-1.70.8-0.80.70.8-2.41.5
Pavlov. Cond. index score0.70.95.00.20.4-0.1-0.8-0.40.3-0.61.3-2.20.9
Pavlov. Cond. latency score1.01.37.0-0.10.10.0-0.9-0.60.4-0.81.6-2.61.2
Pavlov. Cond. lever contacts0.60.73.70.40.6-0.4-1.20.0-0.0-0.41.0-1.90.6
Pavlov. Cond. magazine entry number0.30.40.9-0.7-0.80.70.9-0.30.4-0.0-0.11.0-0.1
Pavlov. Cond. intertrial magazine entries0.70.83.7-0.2-0.10.60.9-0.21.20.81.0-0.11.9
Pavlov. Cond. lever-magazine prob. diff.0.50.63.60.10.3-0.2-0.8-0.30.1-0.51.0-1.90.7
Pavlov. Cond. response bias0.50.62.50.70.9-0.5-0.90.2-0.1-0.10.7-1.60.7
Pavlov. Cond. lever latency0.91.23.4-0.9-0.21.21.8-0.81.6-0.41.2-0.31.3
Pavlov. Cond. magazine entry latency0.60.71.71.10.6-0.9-1.30.6-1.10.4-0.9-0.2-0.8
Pavlov. Cond. change in total contacts0.61.03.40.6-0.0-1.1-1.80.8-1.50.6-0.9-0.1-0.7
Pavlov. Cond. index score1.11.54.21.10.3-1.4-2.01.1-1.90.7-1.20.0-1.0
Pavlov. Cond. latency score0.70.92.80.80.1-1.0-1.70.7-1.50.4-0.9-0.2-0.8
Pavlov. Cond. lever contacts0.71.03.00.7-0.1-1.1-1.70.7-1.50.4-1.00.2-1.1
Pavlov. Cond. magazine entry number1.61.94.7-1.4-1.01.72.2-1.11.8-0.81.4-0.01.2
Pavlov. Cond. intertrial magazine entries0.61.01.9-1.0-0.61.11.4-0.91.3-1.11.0-0.10.4
Pavlov. Cond. lever-magazine prob. diff.1.21.64.51.20.4-1.5-2.11.1-1.90.8-1.2-0.1-1.0
Pavlov. Cond. response bias1.11.64.01.00.4-1.4-2.01.0-1.80.6-1.40.4-1.4
Time in closed arm before self-admin5.36.811.90.60.6-2.9-3.43.0-3.42.8-3.02.2-2.0
Time in closed arm after self-admin3.84.18.31.00.7-2.3-2.32.5-2.92.3-2.51.5-1.0
Time in open arm before self-admin1.31.42.90.2-0.21.00.9-1.21.7-1.71.7-1.40.8
Time in open arm after self-admin2.42.66.7-0.3-0.21.61.4-2.12.6-2.02.1-0.91.0
Bone: periosteal estimation1.83.97.62.72.8-2.2-1.82.3-1.51.9-1.71.2-0.8
Bone: periosteal perimeter4.78.011.03.03.2-3.0-2.43.3-2.53.2-3.02.8-1.4
Bone: post-yield work0.20.30.70.60.80.30.5-0.10.60.00.6-0.50.8
Progressive ratio test 1 active lever presses2.12.65.21.31.0-1.9-2.22.0-2.31.6-1.4-0.0-0.6
Progressive ratio test 1 breakpoint1.92.34.61.21.0-1.8-2.11.9-2.21.6-1.3-0.1-0.5
Progressive ratio test 1 inactive lever presses1.72.54.91.20.9-1.6-1.41.6-1.51.4-2.02.2-1.5
Progressive ratio test 2 active lever presses1.01.11.91.10.9-1.1-0.81.2-1.41.1-1.30.7-0.7
Progressive ratio test 2 breakpoint0.70.81.41.00.8-0.9-0.61.0-1.20.8-1.10.5-0.6
Progressive ratio test 2 inactive lever presses1.11.84.71.31.0-1.3-1.01.7-1.52.2-1.20.9-0.1
Incentive Sensitization - Responses0.10.10.30.40.40.00.50.3-0.50.2-0.4-0.1-0.0
Incentive Sensitization - Breakpoint0.10.10.50.30.30.20.70.1-0.2-0.1-0.2-0.1-0.0
Sum of active levers in priming session hrs 5-63.93.78.3-1.0-0.62.22.8-2.22.9-1.32.1-0.81.6
Progressive ratio0.10.10.40.10.20.30.7-0.10.30.1-0.10.60.2
Food seeking constrained by brief footshock0.91.13.50.30.60.91.9-0.51.40.50.80.31.7
Seeking ratio, punishment vs. effort0.50.72.0-0.10.00.70.8-0.71.2-0.31.2-0.91.4
Retroperitoneal fat weight2.29.615.03.63.9-3.8-3.43.4-3.13.2-2.71.4-1.2
Reaction time number correct0.20.41.00.40.80.1-0.1-0.61.0-1.00.7-0.0-0.4
Reaction time mean minus median0.00.10.4-0.3-0.3-0.0-0.40.0-0.4-0.40.2-0.6-0.2
Reaction time mean minus median AUC0.10.10.5-0.3-0.3-0.2-0.50.4-0.70.1-0.2-0.1-0.3
Reaction time num false alarms0.81.11.90.60.7-1.0-1.01.0-1.41.4-1.31.3-0.6
Reaction time num false alarms AUC0.50.81.60.50.5-0.8-0.70.8-1.21.3-1.11.2-0.4
Reaction time trials correct on left0.20.41.00.40.80.1-0.1-0.61.0-1.00.7-0.0-0.4
Reaction time trials on left0.20.40.90.50.9-0.0-0.2-0.50.9-1.00.60.0-0.5
Reaction time mean1.11.73.70.40.5-1.2-1.01.5-1.71.0-1.91.4-1.5
Reaction time mean AUC0.71.12.5-0.2-0.1-0.7-0.71.1-1.50.4-1.61.1-1.5
Median of all reaction times1.42.04.90.40.6-1.2-0.71.6-1.71.3-2.21.8-1.5
Reaction time omissions1.52.14.70.90.9-1.7-2.01.6-2.20.8-1.40.7-1.5
Reaction time false alarm rate0.71.03.00.50.3-0.9-0.71.1-1.51.7-1.10.70.2
Reaction time premature initiation rate0.71.03.6-0.6-0.30.70.3-0.50.8-0.61.5-1.91.4
Reaction time premature initiations0.40.72.4-0.30.20.4-0.1-0.50.9-0.91.4-1.50.7
Std. dev. reaction times0.40.81.60.50.5-1.0-1.10.9-1.30.4-1.00.5-1.1
Reaction time trials completed0.20.40.90.50.9-0.0-0.2-0.50.9-1.00.60.0-0.5
Reaction time trials AUC0.20.41.00.71.0-0.2-0.3-0.30.7-0.80.50.1-0.6
Run reversals in cocaine runway, females3.43.45.31.91.7-2.0-1.82.3-2.22.2-1.81.2-0.7
Run reversals in cocaine runway, males0.90.91.5-1.0-1.11.10.9-1.11.0-1.20.9-0.30.1
Latency to leave start box in cocaine runway0.00.10.20.20.2-0.2-0.10.2-0.2-0.4-0.0-0.4-0.3
Latency to leave start box in cocaine runway, F0.20.20.50.70.7-0.6-0.60.6-0.50.1-0.2-0.2-0.0
Latency to leave start box in cocaine runway, M0.30.30.8-0.9-0.80.60.7-0.40.2-0.70.1-0.3-0.3
Std. dev. time between licks in bursts1.41.93.21.31.8-1.8-1.71.7-1.41.6-0.90.10.2
Total sessions with >9 infusions4.04.98.12.11.9-2.4-2.12.8-2.52.2-2.51.8-1.2
Short access day 1 total inactive lever presses1.62.14.41.41.1-1.3-0.51.9-1.42.1-1.71.7-0.4
Short access day 10 total inactive lever presses0.41.04.4-2.1-2.10.5-0.1-0.4-0.3-0.1-0.30.7-0.7
Short access day 1 total infusions3.14.16.32.42.4-2.3-1.82.5-2.02.2-1.91.3-0.6
Short access day 10 total infusions0.81.02.01.31.0-1.0-0.71.4-1.01.4-0.60.30.3
Short access total infusions2.02.64.81.81.5-1.8-1.52.2-2.01.8-1.60.7-0.5
Short access day 1 locomotion5.26.59.82.42.2-2.9-2.43.1-2.82.7-2.92.2-1.1
Short access day 10 total locomotion1.12.14.42.11.8-1.6-1.31.5-0.81.4-1.11.5-0.4
Short access total locomotion2.53.05.02.21.9-2.0-1.62.1-1.61.8-1.61.3-0.4
One hour access (0.3 mA shock)0.60.72.61.00.8-0.40.10.9-0.61.6-0.3-0.21.0
Compulsive drug intake0.91.12.2-1.2-1.01.31.5-0.90.9-0.51.0-0.91.0
One hour access (shock baseline)1.82.73.71.91.5-1.8-1.41.9-1.81.9-1.81.3-0.7
Social response proportion2.02.35.82.22.3-1.3-0.71.5-0.52.4-0.40.61.3
Social responses0.60.82.90.91.4-0.10.10.20.80.71.0-0.61.7
Social time0.20.21.3-0.2-0.30.10.00.20.20.80.30.11.1
Soleus weight0.82.45.41.41.3-1.9-2.01.8-2.31.4-1.2-0.4-0.2
Bone: stiffness4.06.69.43.03.1-3.1-3.13.1-2.42.7-2.11.0-0.6
Tibialis anterior weight0.10.40.90.90.8-0.6-0.90.00.0-0.30.4-0.70.2
Time to tail flick, vehicle, before self-admin0.50.51.41.20.9-0.00.70.7-0.20.9-0.71.1-0.1
Time to tail flick, vehicle, after self-admin0.50.62.0-0.6-0.2-0.6-0.80.3-0.4-0.4-1.01.3-1.4
Time to tail flick, test, before self-admin1.71.74.30.60.7-1.4-1.11.5-1.52.1-1.51.4-0.3
Time to tail flick, test, after self-admin0.40.42.2-0.5-0.40.91.5-0.50.6-0.10.10.40.4
Delta time to tail flick, vehicle, before/after SA0.60.52.6-1.6-1.00.1-0.4-0.50.4-0.90.3-0.0-0.4
Delta time to tail flick, test, before/after SA1.11.12.5-0.0-0.11.31.6-1.11.4-1.31.1-0.90.6
Tibia length0.41.22.01.21.3-1.2-1.31.4-0.91.3-0.5-0.40.5
Ambulatory time before self-admin0.91.45.20.20.2-1.6-2.31.0-1.70.5-1.0-0.1-1.1
Ambulatory time after self-admin1.82.15.91.11.1-1.9-2.41.2-1.71.0-1.30.7-1.3
Bone: tissue strength0.50.52.20.30.2-0.6-0.90.3-0.7-0.3-0.80.6-1.5
Total heroin consumption0.20.30.70.00.2-0.5-0.80.5-0.80.3-0.5-0.2-0.8
Bone: trabecular number1.01.77.22.52.7-1.1-0.50.60.31.00.1-0.30.7
Bone: trabecular spacing0.20.20.8-0.9-0.80.20.0-0.0-0.4-0.3-0.30.4-0.6
Bone: trabecular thickness0.91.13.91.92.0-0.7-0.30.30.50.80.4-0.51.0
Bone: trabecular tissue density0.40.61.9-0.30.00.60.2-1.20.8-1.40.7-0.8-0.5
Water consumed over 24 hours0.60.82.81.01.00.1-0.0-0.20.5-0.31.2-1.71.2
Number of responses in last shaping day0.50.61.41.11.0-0.30.10.6-0.00.90.4-0.51.2