Hub : Genes

Irf6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Irf6 0.29 0.18 0.0e+00 0.1 0.14 0.12 0.14 3.0e-15 6.6e-21 1.7e-17 9.3e-21
2 PL gene expression Irf6 0.23 0.11 0.0e+00 0.23 0.26 0.26 0.26 9.7e-25 5.4e-28 8.8e-28 5.1e-28
3 Adipose gene expression Irf6 0.06 0.04 1.7e-06 0.04 0.04 0.04 0.04 1.2e-05 5.7e-05 8.8e-06 1.8e-05
4 pVTA gene expression Irf6 0.16 0.08 2.2e-13 0.17 0.18 0.18 0.18 1.5e-13 2.3e-14 2.5e-14 1.8e-14
5 Liver mRNA stability Irf6 0.05 0.03 8.9e-06 0.04 0.04 0.03 0.03 6.5e-05 7.5e-05 1.3e-04 1.2e-04
6 IL gene expression Irf6 0.24 0.12 4.6e-05 0.19 0.18 0.19 0.18 2.4e-05 4.7e-05 2.9e-05 4.8e-05
7 LHb gene expression Irf6 0.33 0.15 3.6e-05 0.09 0.12 0.22 0.16 3.6e-03 9.0e-04 5.9e-06 1.5e-04
8 Brain gene expression Irf6 0.19 0.11 1.1e-13 0.15 0.15 0.14 0.14 7.3e-14 7.6e-14 3.6e-13 4.2e-13
9 Eye gene expression Irf6 0.77 0.15 4.0e-06 0.24 0.15 0.19 0.24 1.6e-04 2.9e-03 7.1e-04 1.3e-04
10 Liver gene expression Irf6 0.22 0.11 0.0e+00 0.11 0.15 0.14 0.14 7.3e-12 4.7e-16 1.2e-15 7.3e-16
11 OFC gene expression Irf6 0.4 0.17 7.3e-05 0.04 0.16 0.13 0.16 4.1e-02 1.4e-04 4.6e-04 1.2e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.30.61.8-1.0-0.9-0.2-0.4-0.1-0.30.1-0.11.01.4-1.1
Area under the delay curve0.10.10.3-0.4-0.5-0.6-0.1-0.4-0.1-0.4-0.30.20.3-0.3
BMI with tail0.10.30.6-0.7-0.8-0.5-0.6-0.7-0.4-0.0-0.50.20.6-0.5
BMI without tail1.02.96.3-2.2-2.5-1.4-2.1-1.9-1.5-0.3-1.70.31.7-1.5
Body weight2.39.921.1-4.2-4.6-2.0-3.8-3.3-3.10.4-3.11.23.4-3.0
Weight adjusted by age1.21.84.0-1.8-1.9-0.3-1.1-0.8-0.8-0.3-1.01.22.0-2.0
Bone surface0.30.51.6-0.6-0.80.4-0.20.10.10.80.21.11.3-1.1
Bone volume0.40.61.4-1.2-1.1-0.5-0.6-0.5-0.6-0.1-0.40.71.2-1.0
Breakpoint value in progressive ratio session0.40.50.9-0.7-0.9-0.4-0.9-1.0-0.90.5-0.7-0.00.4-0.4
Number of licking bursts0.50.93.4-0.1-0.40.80.30.60.80.90.61.81.3-1.3
Context. condit. distance diff. score0.80.92.9-1.1-1.20.1-0.5-0.1-0.20.5-0.11.21.7-1.7
Locomotion velocity, session 10.91.03.11.00.21.40.80.81.21.71.00.90.3-0.4
Locomotion distance, session 11.01.23.2-0.8-1.40.4-0.4-0.20.21.20.01.71.8-1.7
Locomotion velocity, session 20.10.20.4-0.3-0.60.1-0.4-0.20.00.4-0.10.70.6-0.4
Locomotion distance, session 20.00.00.1-0.1-0.3-0.0-0.2-0.3-0.00.4-0.20.20.1-0.0
Locomotion velocity, session 31.61.93.3-1.6-1.8-1.5-1.8-1.8-1.3-0.7-1.7-0.50.7-0.5
Locomotion distance, session 31.92.14.3-1.1-0.9-2.1-1.3-1.8-1.2-2.0-1.7-1.7-0.50.8
Stereotopy head waving bouts, day 32.22.65.81.40.62.41.51.61.82.41.61.70.6-0.8
Stereotopy head waving duration, day 33.03.57.31.30.62.71.62.01.92.71.92.51.0-1.2
Locomotion velocity, session 72.12.35.6-0.4-0.2-2.0-1.0-1.8-1.1-1.9-1.5-2.4-1.51.7
Locomotion distance, session 72.12.76.7-0.10.2-2.1-0.6-1.5-0.8-2.4-1.3-2.6-1.81.9
Stereotopy head waving bouts, day 71.51.74.50.1-0.61.60.50.80.82.10.92.01.5-1.6
Stereotopy head waving duration, day 72.53.07.30.3-0.42.20.91.41.22.61.52.71.8-2.0
Locomotion velocity, session 81.31.63.60.40.11.70.81.31.01.91.11.81.2-1.3
Locomotion distance, session 80.71.02.7-0.8-1.20.4-0.4-0.10.01.0-0.11.41.7-1.5
Degree of sensitization distance0.50.51.10.91.00.61.00.80.60.20.90.0-0.60.4
Degree of sensitization stereotypy0.30.41.0-0.2-0.40.60.10.30.20.90.41.00.8-0.8
Conditioned locomotion1.11.22.31.51.31.21.31.21.30.81.50.6-0.60.3
Cocaine response after cond. corrected0.70.91.41.10.71.21.01.11.11.01.10.8-0.10.0
Cocaine response after cond. not corrected1.61.83.21.00.61.81.31.51.51.81.51.70.7-0.7
Cocaine response before conditioning0.50.61.8-0.6-0.70.4-0.20.2-0.00.70.11.11.3-1.2
Saline control response0.81.01.9-1.4-1.2-1.4-0.8-1.0-0.8-1.3-0.70.51.0-0.8
Bone: connectivity density1.01.54.1-0.6-0.90.90.10.60.61.30.62.02.0-1.9
Bone: cortical apparent density0.20.31.00.20.3-0.3-0.1-0.2-0.3-0.4-0.4-1.0-0.80.8
Bone: cortical area1.01.53.2-1.7-1.8-0.8-1.3-1.2-1.00.1-1.10.51.5-1.3
Bone: cortical porosity0.91.01.80.50.41.11.21.11.01.01.31.30.7-1.0
Bone: cortical porosity0.70.81.30.40.40.91.11.00.90.71.21.10.7-0.9
Bone: cortical thickness0.30.51.3-0.5-0.70.4-0.10.0-0.00.90.00.81.1-1.1
Bone: cortical thickness1.11.33.5-1.1-1.30.4-0.5-0.1-0.11.3-0.11.41.9-1.9
Bone: cortical tissue density0.20.31.10.30.4-0.3-0.1-0.2-0.3-0.5-0.4-1.1-0.90.9
Condit. Reinf. active minus inactive responses0.91.02.1-0.9-0.8-1.5-0.9-1.3-0.8-1.2-1.1-1.1-0.10.4
Condit. Reinf. active-inactive response ratio0.10.10.40.10.2-0.50.2-0.10.2-0.60.0-0.5-0.40.5
Condit. Reinf. active responses2.42.95.1-2.0-1.8-2.3-2.0-2.2-1.9-1.6-2.0-1.10.4-0.1
Condit. Reinf. inactive responses1.72.14.1-2.0-1.9-1.4-1.8-1.6-1.7-0.7-1.50.11.2-0.9
Incentive salience index mean2.02.54.7-1.7-1.4-2.2-1.8-2.0-1.7-1.7-1.8-1.20.20.2
Condit. Reinf. lever presses2.94.16.5-2.5-2.1-2.5-2.6-2.5-2.5-1.5-2.3-0.90.7-0.4
Condit. Reinf. active minus inactive responses0.20.31.4-0.30.1-0.9-0.1-0.4-0.4-1.2-0.4-0.6-0.30.3
Condit. Reinf. active-inactive response ratio0.40.51.30.91.10.30.80.50.5-0.20.5-0.6-1.00.8
Condit. Reinf. active responses0.81.12.9-1.0-0.5-1.6-0.8-1.1-1.1-1.7-1.1-1.1-0.20.4
Condit. Reinf. inactive responses2.73.56.0-2.4-2.1-2.3-2.1-2.1-2.2-1.6-2.2-0.61.0-0.6
Condit. Reinf. lever presses1.11.52.8-1.5-1.1-1.7-1.2-1.5-1.3-1.5-1.3-0.60.3-0.3
Condit. Reinf. lever reinforcers received0.70.92.2-0.9-0.5-1.5-0.7-1.1-1.0-1.5-1.0-1.0-0.20.3
Conditioned reinforcement - actives0.30.51.7-0.3-0.80.4-0.10.00.20.80.21.31.1-1.1
Conditioned reinforcement - inactives0.81.22.7-0.8-1.40.4-0.6-0.6-0.21.5-0.21.61.6-1.7
Conditioned locomotion1.51.94.9-1.0-1.60.7-0.5-0.20.11.50.02.22.2-2.2
Patch foraging indifference point 0 sec0.81.44.2-0.9-1.20.5-0.00.20.41.00.32.02.1-1.9
Patch foraging indifference point AUC0.50.82.20.91.1-0.20.30.20.4-0.70.0-1.3-1.51.4
Delay disc. indifference point, 0s delay0.10.11.00.2-0.30.30.1-0.20.21.00.10.40.3-0.3
Delay disc. indifference point, 16s delay0.10.10.3-0.3-0.4-0.30.0-0.00.1-0.20.00.60.5-0.5
Delay disc. indifference point, 2s delay0.20.30.5-0.6-0.7-0.7-0.1-0.5-0.1-0.5-0.20.40.7-0.6
Delay disc. indifference point, 24s delay0.30.31.6-0.7-0.5-0.8-0.4-0.3-0.3-1.3-0.40.20.4-0.1
Delay disc. indifference point, 4s delay1.01.01.8-1.2-1.1-1.3-1.1-1.3-1.1-0.8-1.2-0.50.4-0.2
Delay disc. indifference point, 8s delay0.20.30.60.70.60.10.80.40.70.10.5-0.1-0.50.4
Indifference point function ln k1.01.84.40.2-0.31.60.91.01.02.01.12.11.5-1.5
Indifference point function log k1.01.84.40.2-0.31.60.91.01.02.01.12.11.5-1.5
Patch foraging total patch changes 0 sec0.81.44.4-0.9-1.20.5-0.10.20.41.00.32.02.1-1.9
Patch foraging total patch changes 12 sec0.40.51.1-0.9-1.0-0.2-0.7-0.4-0.20.2-0.50.71.0-0.9
Patch foraging total patch changes 18 sec0.10.20.4-0.5-0.6-0.5-0.6-0.6-0.4-0.2-0.6-0.20.2-0.1
Patch foraging total patch changes 24 sec0.40.81.4-1.2-0.9-1.1-1.1-1.0-0.9-0.8-1.0-0.30.4-0.2
Patch foraging total patch changes 6 sec0.30.51.2-1.1-0.9-0.8-0.9-0.8-0.7-0.5-0.70.10.6-0.4
Patch foraging time to switch 0 sec0.30.71.7-1.0-1.1-0.3-1.3-0.7-1.20.3-0.9-0.20.5-0.4
Patch foraging water rate 0 sec0.91.93.91.11.01.22.01.61.80.91.81.70.6-0.8
Patch foraging water rate 12 sec0.51.12.41.41.50.81.51.11.00.31.3-0.0-0.90.7
Patch foraging water rate 18 sec0.20.30.40.60.50.60.60.60.60.60.60.2-0.1-0.1
Patch foraging water rate 24 sec0.40.50.80.80.60.80.90.70.80.90.90.5-0.0-0.1
Patch foraging water rate 6 sec0.30.41.10.40.00.40.80.41.10.20.70.90.5-0.5
Seeking ratio, delayed vs. immediate footshock0.70.92.8-1.0-0.3-1.4-0.8-0.9-1.0-1.7-0.8-0.8-0.10.2
Distance traveled before self-admin1.92.57.8-0.7-1.61.00.00.30.71.10.62.82.6-2.7
Distance traveled after self-admin1.11.33.9-0.2-0.91.30.20.50.51.20.62.01.6-1.8
Extensor digitorum longus weight0.62.23.8-1.1-0.6-1.7-1.7-1.7-1.9-1.3-1.7-1.9-0.91.0
Bone: elastic displacement1.82.13.30.90.61.81.51.61.71.71.81.70.9-1.2
Bone: elastic work1.11.52.60.50.21.51.11.21.31.61.41.51.0-1.2
Bone: endosteal estimation0.10.20.5-0.4-0.6-0.7-0.5-0.7-0.3-0.5-0.5-0.4-0.00.2
Bone: endosteal perimeter0.81.73.0-1.4-1.4-1.7-1.5-1.7-1.4-1.3-1.5-0.70.30.0
Epididymis fat weight0.51.85.1-0.6-1.01.1-0.00.30.31.90.42.22.0-2.3
Delta time in closed arm before/after self-admin0.20.20.60.60.70.10.30.2-0.0-0.00.2-0.5-0.80.7
Delta time in open arm before/after self-admin3.13.04.8-2.1-1.9-2.2-2.1-2.1-2.0-1.5-2.1-1.00.4-0.0
Diff in mean of infusions in LGA sessions0.30.40.9-0.7-0.8-0.3-0.4-0.4-0.50.5-0.20.60.9-0.9
Delay discount exponential model param0.20.20.50.50.60.70.20.40.10.60.3-0.2-0.40.3
Extinction: sum of active levers before priming2.52.85.5-2.2-2.3-1.3-2.1-1.8-2.0-0.3-1.9-0.01.4-1.2
Active lever presses in extinction session 62.12.14.6-1.6-2.1-0.3-1.5-1.3-1.21.4-1.10.81.7-1.9
Bone: final force0.30.51.1-0.4-0.70.5-0.2-0.0-0.11.10.20.91.0-1.1
Bone: final moment0.30.41.0-0.7-0.90.1-0.5-0.4-0.40.7-0.10.61.0-1.0
Food consumed during 24 hour testing period0.30.40.90.4-0.20.70.40.30.90.90.60.90.6-0.6
Glucose0.71.12.51.10.91.21.31.21.60.71.30.8-0.0-0.1
Heart weight0.81.22.3-1.5-1.4-1.1-1.5-1.2-1.3-0.3-1.1-0.00.8-0.7
Delay discount hyperbolic model param0.30.30.80.70.80.90.40.60.30.70.5-0.2-0.60.4
Intermittent access intake day 1-15 change1.73.56.72.62.22.22.01.82.02.02.10.2-1.30.8
Intermittent access intake escalation2.04.07.22.72.22.52.22.12.32.12.30.5-1.10.7
Intermittent access intake escalation 22.52.85.02.21.82.11.81.72.01.81.90.5-0.90.5
Intermitt. access day 1 inactive lever presses0.00.10.3-0.1-0.2-0.2-0.5-0.5-0.50.1-0.5-0.5-0.30.4
Intermitt. access day 15 inactive lever presses0.30.61.4-0.8-0.8-0.8-1.2-1.0-1.1-0.1-1.0-0.8-0.10.2
Intermitt. access escalation Index0.30.51.40.00.1-0.8-0.4-0.6-0.5-0.7-0.7-1.2-0.90.9
Intermittent access day 1 total infusions0.81.32.9-1.5-1.7-0.5-1.2-0.9-1.00.1-0.91.01.5-1.4
Intermittent access day 15 total infusions1.72.66.91.40.82.31.31.71.62.61.71.70.4-0.7
Intermittent access terminal intake (last 3 days)0.91.24.21.30.71.70.81.01.12.11.10.7-0.30.1
Intermittent access total infusions0.60.81.90.4-0.11.20.50.70.71.30.81.40.7-0.8
Intermittent access day 1 locomotion1.31.73.6-1.6-1.9-0.1-1.2-0.7-0.90.6-0.81.41.9-1.8
Intermittent access day 15 total locomotion0.81.54.0-0.2-0.91.30.10.50.62.00.51.91.6-1.7
Intermittent access total locomotion1.21.43.8-1.0-1.50.4-0.6-0.1-0.11.1-0.21.81.9-1.9
Intermittent access standard deviation0.30.61.31.11.00.70.50.40.30.80.7-0.3-1.00.8
Left kidney weight0.94.19.3-2.5-3.0-0.6-2.1-1.8-1.41.1-1.41.62.7-2.6
Right kidney weight0.94.19.3-2.2-3.0-0.1-2.0-1.5-1.21.8-1.41.82.8-2.7
Cocaine induced anxiety1.62.23.6-1.3-1.0-1.6-1.8-1.8-1.9-1.6-1.9-1.5-0.40.6
Post-drug Anxiety0.30.30.90.20.1-0.1-0.4-0.4-0.5-0.1-0.5-0.9-0.80.8
Baseline Anxiety5.26.09.02.82.42.93.02.93.02.53.01.4-0.50.2
Tail length2.59.618.5-4.1-4.3-2.7-3.9-3.4-3.3-0.7-3.30.32.7-2.4
Length with tail3.113.327.9-4.8-5.3-2.5-4.5-3.9-3.70.3-3.81.03.7-3.3
Length without tail1.13.47.1-2.3-2.7-0.3-1.8-1.5-1.41.3-1.31.72.5-2.4
Times rat made contact with spout0.10.10.4-0.0-0.20.30.10.10.20.30.20.60.4-0.6
Lifetime Intake0.60.72.10.1-0.31.10.20.60.51.20.51.41.0-1.0
Liver weight, left0.30.41.0-0.7-0.90.1-0.5-0.3-0.40.6-0.20.81.0-1.0
Liver weight, right0.91.53.70.1-0.21.50.71.10.91.71.01.91.3-1.5
Locomotor activity0.50.83.00.90.31.30.70.61.01.70.80.80.1-0.4
Locomotor testing distance0.10.10.80.40.10.60.20.10.30.90.30.3-0.0-0.1
Locomotor testing rearing0.00.10.20.30.3-0.10.2-0.10.0-0.20.1-0.2-0.40.5
Locomotion in novel chamber0.10.20.60.10.3-0.30.0-0.1-0.2-0.3-0.1-0.8-0.70.7
Locomotion in novel chamber post-restriction0.00.10.2-0.00.10.00.30.10.3-0.50.20.20.1-0.3
Fecal boli incidents, locomotor time 10.10.10.50.20.30.20.10.10.20.70.2-0.2-0.30.1
Change in fecal boli incidents, locomotor task0.30.30.80.60.60.90.70.80.30.40.70.2-0.10.1
Time >=10cm from walls, locomotor time 10.20.20.70.50.00.50.40.30.60.90.40.50.1-0.2
Bouts of movement, locomotor time 10.91.01.81.10.81.31.31.31.20.41.21.1-0.00.0
Total resting periods, locomotor time 10.50.61.00.90.70.91.00.90.9-0.10.90.7-0.20.2
Rest time, locomotor task time 10.91.12.01.41.21.21.41.31.10.61.20.5-0.60.6
Distance moved, locomotor task time 10.30.40.9-0.6-1.0-0.2-0.8-0.7-0.60.8-0.60.30.6-0.7
Vertical activity count, locomotor time 10.10.30.9-0.3-0.40.3-0.00.20.20.20.20.90.8-0.9
Time >=10cm from walls, locomotor time 20.60.91.8-1.0-1.1-1.0-1.3-1.4-0.90.2-1.3-0.50.2-0.1
Bouts of movement, locomotor time 20.10.10.40.20.10.10.50.30.6-0.30.10.00.00.1
Total resting periods, locomotor time 20.00.10.30.1-0.00.00.40.20.5-0.30.00.10.10.0
Rest time, locomotor task time 21.21.53.31.81.61.01.51.11.10.51.1-0.5-1.41.2
Distance moved, locomotor task time 21.21.42.7-1.4-1.6-0.2-1.4-0.9-0.80.9-0.71.01.6-1.6
Vertical activity count, locomotor time 20.30.41.2-0.6-0.60.3-0.30.00.10.20.11.01.0-1.1
Light reinforcement 10.71.73.01.10.91.71.51.71.31.61.41.30.3-0.7
Light reinforcement 22.13.26.41.50.92.51.82.12.02.51.81.80.5-0.9
Bone: marrow area0.10.20.3-0.3-0.4-0.6-0.4-0.6-0.2-0.4-0.4-0.4-0.10.3
Bone: maximum diameter0.51.01.9-1.3-1.4-1.0-1.2-1.2-0.9-0.2-1.1-0.10.8-0.5
Bone: maximum force0.71.23.3-0.4-0.91.00.10.30.51.80.61.51.6-1.6
Bone: maximum moment0.61.02.6-0.7-1.10.6-0.2-0.00.11.40.21.31.6-1.6
Mean time between licks in bursts0.40.92.1-0.3-0.1-1.1-0.9-1.0-0.8-1.0-1.0-1.5-0.91.1
Mean num. licks in bursts0.40.72.60.00.3-0.7-0.3-0.6-0.7-0.8-0.7-1.6-1.11.0
Cd content in liver7.48.215.7-4.0-3.9-2.6-3.5-3.0-3.0-1.1-3.00.42.7-2.3
Co content in liver1.51.83.80.50.11.71.11.41.41.71.31.91.2-1.3
Cu content in liver2.22.65.92.12.40.71.61.21.0-0.21.2-1.2-2.32.1
Fe content in liver1.62.04.51.72.00.21.20.70.7-0.80.8-1.4-2.12.1
K content in liver0.60.61.31.11.10.40.70.50.6-0.10.5-0.5-1.11.0
Mg content in liver0.60.61.7-0.0-0.20.80.40.60.50.90.61.30.9-1.1
Mn content in liver0.30.30.7-0.8-0.6-0.7-0.6-0.5-0.7-0.6-0.50.00.5-0.6
Na content in liver1.51.73.61.71.80.41.20.90.7-0.40.9-1.0-1.91.9
Rb content in liver0.80.92.41.11.40.20.90.50.4-0.40.5-1.0-1.51.3
Se content in liver0.30.30.90.0-0.30.50.20.30.50.50.30.90.8-0.8
Sr content in liver1.91.73.5-1.0-0.5-1.8-1.2-1.3-1.4-1.9-1.4-1.5-0.60.8
Zn content in liver3.64.011.2-1.4-1.91.2-0.40.40.22.30.33.23.2-3.3
Bone: minimum diameter1.93.57.1-2.0-1.5-2.7-1.9-2.3-2.0-2.2-2.2-1.50.00.4
Time in familiar zone, hab. session 11.41.32.7-0.00.0-1.5-0.7-1.1-0.7-1.6-1.0-1.7-1.31.5
Time in novel zone, hab. session 10.60.61.5-0.9-1.00.3-0.7-0.2-0.61.0-0.40.71.1-1.2
Total zone transitions, hab. session 10.50.71.9-0.8-1.40.0-0.7-0.6-0.10.9-0.50.71.3-1.1
Total locomotion distance, hab. session 10.60.83.50.2-0.51.20.30.40.71.90.41.20.9-1.0
Locomotion velocity, hab. session 10.91.33.90.3-0.31.40.60.81.02.00.81.71.1-1.3
Time in familiar zone, hab. session 20.20.20.5-0.5-0.7-0.7-0.5-0.7-0.2-0.4-0.5-0.30.2-0.1
Time in novel zone, hab. session 20.30.30.7-0.7-0.5-0.4-0.8-0.6-0.8-0.2-0.7-0.10.2-0.2
Total zone transitions, hab. session 21.01.33.1-1.5-1.8-0.6-1.2-1.0-0.80.3-1.00.71.5-1.3
Total locomotion distance, hab. session 20.50.71.6-0.8-1.3-0.1-0.7-0.6-0.20.7-0.60.81.2-1.0
Locomotion velocity, hab. session 20.40.51.4-0.6-1.00.2-0.4-0.20.10.9-0.21.01.2-1.1
Novel to familiar place preference ratio0.00.00.2-0.2-0.10.30.00.2-0.10.10.00.20.3-0.5
Novelty place preference0.10.10.3-0.3-0.30.3-0.10.1-0.10.2-0.10.30.5-0.6
Time in novel zone, NPP test0.10.10.3-0.4-0.30.2-0.2-0.0-0.30.1-0.20.20.4-0.5
Total zone transitions, NPP test1.21.74.3-1.3-1.80.1-0.9-0.6-0.31.2-0.41.62.1-2.0
Total locomotion distance, NPP test0.60.82.0-0.9-1.3-0.0-0.6-0.5-0.00.8-0.31.11.4-1.3
Locomotion velocity, NPP test0.60.82.0-0.8-1.40.0-0.5-0.50.10.8-0.31.11.4-1.3
Intraocular pressure0.40.61.20.60.50.90.90.91.10.70.90.70.2-0.4
Delta distance traveled before/after self-admin0.20.30.90.10.3-0.2-0.2-0.3-0.50.1-0.4-1.0-0.80.7
Delta ambulatory time before/after self-admin0.10.20.40.40.60.10.30.2-0.1-0.00.0-0.5-0.60.6
Parametrial fat weight0.40.91.8-0.6-0.7-1.0-1.2-1.3-1.1-0.5-1.3-1.1-0.50.5
Pavlov. Cond. lever latency3.74.79.03.02.42.52.72.42.61.52.30.4-1.31.0
Pavlov. Cond. magazine entry latency4.86.210.2-2.9-2.4-3.1-3.2-3.1-3.2-1.9-2.9-1.60.5-0.1
Pavlov. Cond. change in total contacts4.85.18.8-3.0-2.5-2.8-2.8-2.6-2.6-1.9-2.5-0.81.1-0.8
Pavlov. Cond. index score4.25.28.7-2.8-2.1-3.0-2.8-2.7-2.9-2.0-2.6-1.40.5-0.1
Pavlov. Cond. latency score4.65.89.6-3.0-2.3-3.1-3.0-2.8-3.0-2.1-2.7-1.20.7-0.3
Pavlov. Cond. lever contacts2.32.75.2-2.3-1.7-2.0-2.1-1.8-2.1-1.1-1.7-0.50.9-0.7
Pavlov. Cond. magazine entry number4.65.89.92.72.13.03.12.93.12.02.81.8-0.2-0.2
Pavlov. Cond. intertrial magazine entries1.01.12.20.60.31.21.21.21.31.01.21.50.7-0.9
Pavlov. Cond. lever-magazine prob. diff.3.84.68.0-2.7-2.1-2.7-2.7-2.5-2.8-1.7-2.4-1.10.7-0.3
Pavlov. Cond. response bias4.04.98.5-2.7-2.2-2.6-2.9-2.7-2.9-1.5-2.6-1.40.6-0.2
Pavlov. Cond. lever latency1.11.52.81.71.51.51.31.41.30.91.10.0-1.00.9
Pavlov. Cond. magazine entry latency0.91.12.5-1.6-1.3-0.6-1.0-0.7-1.1-0.1-0.70.71.4-1.4
Pavlov. Cond. change in total contacts0.10.20.50.00.5-0.40.2-0.0-0.4-0.70.0-0.7-0.60.3
Pavlov. Cond. index score1.11.43.1-1.8-1.5-1.1-1.2-1.1-1.3-0.5-0.90.41.3-1.3
Pavlov. Cond. latency score1.11.43.2-1.8-1.4-1.2-1.2-1.1-1.4-0.7-1.00.31.2-1.2
Pavlov. Cond. lever contacts0.81.12.0-1.4-1.3-1.2-1.1-1.2-1.2-0.7-0.90.00.9-0.8
Pavlov. Cond. magazine entry number0.40.51.41.10.70.20.40.20.8-0.00.2-0.5-0.91.2
Pavlov. Cond. intertrial magazine entries0.20.30.5-0.4-0.3-0.7-0.6-0.5-0.4-0.7-0.6-0.6-0.20.5
Pavlov. Cond. lever-magazine prob. diff.0.81.12.5-1.6-1.3-0.9-1.0-0.9-1.1-0.5-0.80.41.2-1.3
Pavlov. Cond. response bias1.11.53.1-1.8-1.6-1.3-1.4-1.4-1.4-0.6-1.10.11.2-1.1
Time in closed arm before self-admin0.10.20.30.10.10.40.30.40.50.50.40.60.4-0.4
Time in closed arm after self-admin1.81.94.61.61.31.71.51.31.52.11.50.6-0.50.1
Time in open arm before self-admin0.20.20.5-0.5-0.5-0.4-0.4-0.5-0.5-0.7-0.30.10.4-0.6
Time in open arm after self-admin3.43.86.0-2.1-1.7-2.4-2.2-2.2-2.3-2.4-2.3-1.40.20.2
Bone: periosteal estimation0.51.02.3-1.4-1.5-1.0-1.2-1.3-0.9-0.3-1.10.00.9-0.6
Bone: periosteal perimeter0.91.52.9-1.6-1.7-1.2-1.4-1.5-1.1-0.5-1.4-0.01.0-0.8
Bone: post-yield work0.20.30.50.40.30.70.60.70.60.70.60.40.2-0.1
Progressive ratio test 1 active lever presses0.50.71.3-0.9-1.1-0.8-1.0-1.0-1.0-0.1-1.00.00.5-0.4
Progressive ratio test 1 breakpoint0.40.51.1-0.8-1.0-0.6-0.9-0.9-0.90.0-0.90.10.5-0.3
Progressive ratio test 1 inactive lever presses1.21.73.4-1.4-1.3-1.3-1.8-1.7-1.8-0.8-1.6-0.70.2-0.1
Progressive ratio test 2 active lever presses0.10.10.3-0.2-0.5-0.1-0.4-0.5-0.30.0-0.40.10.1-0.1
Progressive ratio test 2 breakpoint0.00.10.2-0.1-0.4-0.0-0.3-0.4-0.20.2-0.30.10.1-0.1
Progressive ratio test 2 inactive lever presses0.61.12.6-1.0-1.50.3-0.8-0.6-0.40.9-0.51.21.5-1.6
Incentive Sensitization - Responses0.00.00.10.1-0.20.3-0.1-0.2-0.00.2-0.00.20.1-0.2
Incentive Sensitization - Breakpoint0.00.00.10.1-0.20.3-0.1-0.2-0.00.1-0.10.1-0.0-0.0
Sum of active levers in priming session hrs 5-62.62.45.2-2.1-2.3-0.8-1.8-1.3-1.60.2-1.50.61.8-1.7
Progressive ratio2.64.113.5-0.6-1.01.40.81.41.41.11.53.73.1-3.2
Food seeking constrained by brief footshock0.30.30.90.10.5-0.7-0.1-0.3-0.3-0.8-0.2-0.9-0.80.9
Seeking ratio, punishment vs. effort2.33.410.80.40.9-1.5-0.8-1.2-1.3-1.4-1.4-3.3-2.72.9
Retroperitoneal fat weight0.83.57.6-2.2-2.8-0.4-1.8-1.4-1.31.2-1.31.72.6-2.6
Reaction time number correct0.40.83.4-0.9-0.2-1.6-0.3-0.9-0.8-1.8-0.4-0.60.00.1
Reaction time mean minus median1.33.26.61.81.42.61.92.12.02.12.11.50.1-0.5
Reaction time mean minus median AUC1.02.44.31.91.72.11.81.71.71.51.90.7-0.60.2
Reaction time num false alarms1.42.04.71.62.20.21.31.00.9-1.00.7-1.2-2.02.1
Reaction time num false alarms AUC1.32.04.71.82.20.51.41.21.2-0.70.9-1.0-1.91.9
Reaction time trials correct on left0.40.83.4-0.9-0.2-1.6-0.3-0.9-0.8-1.8-0.4-0.60.00.1
Reaction time trials on left0.40.73.0-0.8-0.2-1.5-0.3-0.8-0.7-1.7-0.4-0.40.10.0
Reaction time mean1.62.55.71.81.12.41.61.81.92.01.71.1-0.1-0.2
Reaction time mean AUC1.93.06.31.91.42.51.82.02.12.01.91.1-0.2-0.1
Median of all reaction times0.91.33.01.40.91.71.11.21.51.41.10.5-0.40.2
Reaction time omissions1.92.86.50.70.42.11.42.01.71.81.72.61.4-1.4
Reaction time false alarm rate1.11.53.01.71.71.01.11.21.20.20.7-0.6-1.61.5
Reaction time premature initiation rate0.20.20.70.30.2-0.1-0.2-0.4-0.3-0.1-0.3-0.9-0.80.8
Reaction time premature initiations0.20.30.80.10.3-0.6-0.0-0.5-0.4-0.8-0.2-0.9-0.80.8
Std. dev. reaction times2.85.211.42.01.23.42.22.62.53.12.52.30.6-1.1
Reaction time trials completed0.40.73.0-0.8-0.2-1.5-0.3-0.8-0.7-1.7-0.4-0.40.10.0
Reaction time trials AUC0.50.93.7-0.9-0.3-1.7-0.4-0.9-0.8-1.9-0.5-0.60.10.1
Run reversals in cocaine runway, females0.40.31.00.70.50.00.1-0.20.10.6-0.0-0.9-1.00.9
Run reversals in cocaine runway, males0.70.71.21.01.01.00.80.80.81.10.80.1-0.60.3
Latency to leave start box in cocaine runway0.60.71.80.91.30.01.00.70.6-0.30.6-0.7-1.01.0
Latency to leave start box in cocaine runway, F0.60.71.40.91.10.71.21.21.00.50.90.2-0.30.3
Latency to leave start box in cocaine runway, M0.60.51.30.50.7-0.60.1-0.3-0.1-0.9-0.1-1.1-1.11.1
Std. dev. time between licks in bursts0.70.91.6-1.0-0.8-1.2-1.2-1.2-1.0-1.0-1.3-0.8-0.10.3
Total sessions with >9 infusions0.70.91.8-1.2-1.4-0.4-1.0-0.9-0.90.1-0.80.61.1-1.1
Short access day 1 total inactive lever presses0.20.31.0-0.3-0.70.3-0.5-0.3-0.31.0-0.30.40.5-0.5
Short access day 10 total inactive lever presses0.71.83.1-1.1-0.6-1.6-1.5-1.4-1.6-1.8-1.5-1.6-0.60.8
Short access day 1 total infusions0.40.51.1-1.0-1.0-0.4-0.8-0.6-0.8-0.3-0.70.40.9-0.8
Short access day 10 total infusions0.50.61.5-0.9-1.1-0.1-0.6-0.4-0.40.0-0.41.11.2-1.1
Short access total infusions0.70.82.3-0.9-1.10.3-0.5-0.1-0.30.6-0.21.41.5-1.5
Short access day 1 locomotion1.62.04.1-2.0-1.9-0.8-1.4-0.8-1.1-0.5-1.01.12.0-1.8
Short access day 10 total locomotion0.00.00.2-0.00.00.20.10.30.1-0.40.10.20.1-0.1
Short access total locomotion0.50.61.7-0.8-1.00.1-0.5-0.1-0.30.2-0.21.21.3-1.2
One hour access (0.3 mA shock)0.20.20.4-0.4-0.6-0.1-0.6-0.6-0.50.2-0.30.20.3-0.5
Compulsive drug intake1.92.34.9-0.8-0.1-1.8-1.4-1.4-1.8-2.0-1.4-2.2-1.21.2
One hour access (shock baseline)0.91.43.10.70.11.60.91.11.21.51.21.80.8-1.0
Social response proportion0.00.00.1-0.2-0.0-0.3-0.1-0.1-0.0-0.4-0.3-0.1-0.10.2
Social responses0.50.72.1-0.9-0.7-1.2-0.7-0.7-0.5-1.4-1.0-0.30.20.2
Social time0.00.00.2-0.2-0.1-0.3-0.2-0.00.0-0.4-0.3-0.00.10.1
Soleus weight1.64.78.41.81.72.62.62.92.61.82.82.10.5-0.8
Bone: stiffness0.40.61.5-0.8-1.20.1-0.7-0.5-0.30.9-0.40.61.1-1.0
Tibialis anterior weight0.82.64.5-1.5-1.1-2.0-1.9-2.0-2.1-1.5-2.0-1.6-0.40.6
Time to tail flick, vehicle, before self-admin0.60.61.11.01.00.90.81.00.80.60.7-0.0-0.50.5
Time to tail flick, vehicle, after self-admin0.40.61.3-0.8-1.00.2-0.7-0.3-0.41.0-0.20.91.1-1.1
Time to tail flick, test, before self-admin2.32.34.80.80.22.11.11.61.52.21.52.11.2-1.4
Time to tail flick, test, after self-admin0.80.82.80.0-0.51.00.10.40.61.70.51.31.1-1.2
Delta time to tail flick, vehicle, before/after SA0.80.71.5-1.1-1.2-0.3-0.9-0.7-0.60.5-0.50.71.1-1.2
Delta time to tail flick, test, before/after SA0.40.40.6-0.8-0.7-0.8-0.7-0.8-0.5-0.5-0.7-0.10.3-0.2
Tibia length1.02.95.2-2.2-2.0-1.7-2.3-2.1-2.1-0.7-2.1-0.50.9-0.6
Ambulatory time before self-admin1.52.27.6-0.5-1.21.10.30.50.90.90.92.82.3-2.4
Ambulatory time after self-admin0.91.13.10.5-0.11.40.91.01.00.71.01.71.0-1.2
Bone: tissue strength0.60.61.61.20.61.10.60.50.71.30.7-0.1-0.60.5
Total heroin consumption2.42.85.7-2.2-2.4-0.9-1.8-1.4-1.60.4-1.30.92.1-2.0
Bone: trabecular number0.30.51.6-0.2-0.20.40.50.70.50.40.71.31.0-0.9
Bone: trabecular spacing0.40.51.3-0.7-0.7-0.6-1.0-1.0-1.20.0-0.9-0.7-0.0-0.1
Bone: trabecular thickness0.00.00.1-0.20.1-0.20.20.10.0-0.30.10.20.1-0.2
Bone: trabecular tissue density0.91.34.80.70.7-0.5-0.3-0.6-0.4-0.7-0.7-2.2-1.81.7
Water consumed over 24 hours0.20.31.10.1-0.10.40.40.30.40.30.51.10.6-0.7
Number of responses in last shaping day0.40.40.90.60.30.80.60.50.71.00.70.70.1-0.2