Hub : Genes

Insyn2a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC gene expression Insyn2a 0.22 0.13 7.7e-03 0.07 0.07 0.13 0.12 8.8e-03 8.3e-03 5.0e-04 1.1e-03
2 BLA gene expression Insyn2a 0.09 0.06 4.2e-03 -0 0.03 0.01 0 3.7e-01 1.1e-02 5.0e-02 1.7e-01
3 NAcc gene expression Insyn2a 0.07 0.04 1.2e-07 0.03 0.05 0.05 0.04 4.6e-05 7.4e-08 7.5e-08 2.1e-07
4 Brain gene expression Insyn2a 0.13 0.06 1.5e-10 0.12 0.14 0.11 0.13 3.7e-11 1.0e-12 1.1e-10 3.4e-12
5 IC gene expression Insyn2a 0.12 0.06 1.9e-03 0.08 0.05 0.11 0.13 2.6e-04 5.2e-03 3.5e-05 4.5e-06
6 PL gene expression Insyn2a 0.05 0.03 9.3e-05 0.04 0.04 0.03 0.03 8.5e-05 6.6e-05 4.1e-04 2.4e-04
7 pVTA gene expression Insyn2a 0.06 0.03 1.1e-04 0.03 0.06 0.05 0.06 1.1e-03 1.4e-05 4.7e-05 2.0e-05
8 RMTg isoform ratio NM_001143803.1 0.14 0.08 8.1e-03 0.03 0.02 0.02 0.03 4.6e-02 9.6e-02 1.0e-01 6.6e-02
9 Adipose isoform ratio XM_008759969.4 0.05 0.03 2.3e-04 0.01 0.03 0.01 0.01 3.3e-02 2.0e-04 7.8e-03 1.6e-02
10 Adipose isoform ratio XM_063282543.1 0.05 0.03 1.2e-04 0.02 0.04 0.03 0.03 1.3e-03 6.0e-05 2.9e-04 7.2e-04
11 Adipose gene expression Insyn2a 0.23 0.08 0.0e+00 0.11 0.17 0.16 0.17 2.6e-12 1.4e-18 7.5e-17 1.6e-18

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density1.93.65.7-1.41.02.12.02.32.41.32.1-2.32.3-0.1
Area under the delay curve0.20.30.80.30.2-0.4-0.3-0.8-0.50.3-0.90.3-0.3-0.7
BMI with tail0.10.50.80.40.9-0.7-0.3-0.8-0.9-0.6-0.40.8-0.80.9
BMI without tail0.10.30.8-0.20.90.40.50.40.40.20.8-0.60.60.3
Body weight0.10.31.3-0.41.2-0.00.4-0.5-0.4-0.1-0.00.6-0.60.7
Weight adjusted by age0.00.10.4-0.20.30.30.40.30.4-0.20.5-0.20.20.6
Bone surface2.85.58.3-2.82.52.82.92.52.42.71.5-2.12.0-0.8
Bone volume2.65.37.7-2.52.12.82.82.62.52.41.7-2.32.1-0.6
Breakpoint value in progressive ratio session0.91.52.60.4-0.9-1.4-1.1-1.5-1.6-0.0-1.61.4-1.4-1.1
Number of licking bursts0.51.62.61.4-1.6-1.6-1.4-1.2-1.3-0.9-1.61.0-1.00.0
Context. condit. distance diff. score2.22.74.0-1.62.02.01.91.31.81.21.8-1.71.60.1
Locomotion velocity, session 10.10.10.50.1-0.10.20.00.00.4-0.50.5-0.20.20.7
Locomotion distance, session 10.30.41.40.8-1.0-0.1-0.30.20.5-0.61.2-0.70.80.2
Locomotion velocity, session 20.10.10.2-0.3-0.10.20.20.20.2-0.20.40.2-0.20.4
Locomotion distance, session 20.70.92.41.3-1.4-1.0-1.1-0.7-0.5-1.60.40.6-0.50.8
Locomotion velocity, session 30.40.51.6-0.81.20.60.90.30.11.3-0.6-0.20.1-0.7
Locomotion distance, session 31.01.23.1-1.41.60.71.3-0.4-0.21.7-0.60.3-0.4-1.5
Stereotopy head waving bouts, day 30.50.62.2-0.6-0.10.80.71.50.90.80.6-0.80.70.0
Stereotopy head waving duration, day 30.20.30.9-0.1-0.20.40.21.00.50.60.1-0.80.8-0.3
Locomotion velocity, session 71.01.12.9-1.71.51.21.31.10.51.1-0.20.2-0.30.8
Locomotion distance, session 70.81.13.6-1.91.81.11.40.30.31.1-0.10.4-0.50.2
Stereotopy head waving bouts, day 71.11.32.90.4-0.70.60.51.61.30.51.6-1.71.7-0.0
Stereotopy head waving duration, day 71.62.04.40.1-0.11.10.92.11.80.61.9-2.12.10.4
Locomotion velocity, session 80.60.72.3-1.51.51.00.90.10.40.8-0.1-0.0-0.1-0.3
Locomotion distance, session 80.40.51.2-0.80.80.91.00.20.80.41.1-0.60.6-0.1
Degree of sensitization distance0.20.21.50.0-0.20.0-0.30.20.1-0.80.30.1-0.11.2
Degree of sensitization stereotypy0.70.81.90.5-0.50.40.41.11.10.21.3-1.41.40.2
Conditioned locomotion0.30.40.8-0.10.10.60.40.70.80.20.7-0.90.9-0.1
Cocaine response after cond. corrected1.11.72.7-0.81.31.51.11.41.6-0.11.6-1.31.41.5
Cocaine response after cond. not corrected0.71.12.9-0.81.11.20.81.21.2-0.41.1-0.80.71.7
Cocaine response before conditioning0.80.92.00.4-0.9-0.9-0.8-0.6-1.2-0.4-1.21.4-1.40.2
Saline control response0.81.18.9-0.30.2-0.10.2-1.0-0.41.5-0.3-0.10.1-3.0
Bone: connectivity density1.82.94.3-1.81.42.02.02.11.91.71.3-1.71.7-0.4
Bone: cortical apparent density1.22.03.10.9-1.3-1.5-1.4-1.6-1.6-1.1-1.51.7-1.80.2
Bone: cortical area0.40.64.10.4-0.5-0.1-0.20.80.2-0.90.90.1-0.12.0
Bone: cortical porosity0.20.21.1-0.30.30.20.2-0.00.10.7-0.5-0.30.2-1.1
Bone: cortical porosity0.10.10.30.4-0.3-0.1-0.30.00.2-0.1-0.2-0.50.5-0.5
Bone: cortical thickness0.81.37.50.5-0.8-0.5-0.60.3-0.4-1.70.41.0-0.92.7
Bone: cortical thickness0.20.31.1-0.70.60.40.40.30.1-0.10.10.4-0.51.1
Bone: cortical tissue density1.32.03.40.7-1.2-1.5-1.3-1.7-1.7-1.0-1.61.8-1.80.1
Condit. Reinf. active minus inactive responses1.71.94.01.0-1.3-1.6-1.5-2.0-1.7-0.6-1.31.4-1.3-1.2
Condit. Reinf. active-inactive response ratio1.11.12.40.7-1.0-1.2-1.1-1.6-1.2-0.3-1.00.9-0.8-1.3
Condit. Reinf. active responses0.91.12.21.3-1.5-1.3-1.3-1.4-1.1-1.1-0.10.8-0.6-0.2
Condit. Reinf. inactive responses0.30.41.00.8-0.9-0.2-0.40.10.4-0.91.0-0.60.70.5
Incentive salience index mean1.62.03.21.5-1.7-1.8-1.7-1.7-1.6-1.2-0.71.3-1.2-0.2
Condit. Reinf. lever presses0.91.44.01.9-2.0-1.1-1.4-0.1-0.4-1.60.70.2-0.01.1
Condit. Reinf. active minus inactive responses0.10.20.70.2-0.5-0.00.10.20.20.50.7-0.50.5-0.8
Condit. Reinf. active-inactive response ratio0.40.71.4-0.30.20.50.70.80.81.10.6-1.21.2-1.0
Condit. Reinf. active responses0.20.30.60.5-0.7-0.6-0.4-0.6-0.6-0.00.30.3-0.2-0.7
Condit. Reinf. inactive responses0.40.61.60.6-0.6-0.8-0.9-1.2-0.9-0.9-0.11.0-0.90.0
Condit. Reinf. lever presses0.30.51.40.2-0.2-0.6-0.3-0.9-0.90.4-0.70.7-0.7-1.2
Condit. Reinf. lever reinforcers received0.20.30.90.4-0.6-0.7-0.4-0.8-0.70.10.00.5-0.5-0.9
Conditioned reinforcement - actives3.212.824.65.0-4.1-4.7-4.2-4.1-3.7-3.2-2.52.5-2.4-0.5
Conditioned reinforcement - inactives2.15.88.72.7-2.6-3.0-2.9-2.8-2.6-2.3-1.52.2-2.10.3
Conditioned locomotion11.917.730.85.5-5.0-5.6-5.0-4.9-4.5-3.2-3.22.9-2.7-1.6
Patch foraging indifference point 0 sec0.72.03.5-1.10.81.51.71.81.41.91.2-1.41.4-0.8
Patch foraging indifference point AUC0.00.00.20.1-0.4-0.1-0.1-0.0-0.00.10.3-0.20.2-0.3
Delay disc. indifference point, 0s delay1.01.13.3-1.01.81.01.1-0.20.51.6-0.1-0.80.7-1.5
Delay disc. indifference point, 16s delay0.10.20.40.3-0.3-0.5-0.5-0.4-0.6-0.1-0.60.5-0.5-0.0
Delay disc. indifference point, 2s delay0.20.20.60.7-0.5-0.3-0.20.10.10.2-0.1-0.50.5-0.7
Delay disc. indifference point, 24s delay1.11.73.71.0-0.5-1.5-1.4-1.7-1.6-0.8-1.91.3-1.3-0.1
Delay disc. indifference point, 4s delay1.01.02.90.10.7-0.6-0.3-1.6-1.10.7-1.70.8-0.9-1.3
Delay disc. indifference point, 8s delay0.10.20.40.3-0.1-0.4-0.4-0.7-0.40.0-0.60.3-0.3-0.6
Indifference point function ln k0.10.31.80.30.00.30.20.50.5-0.60.7-0.40.41.3
Indifference point function log k0.10.31.80.30.00.30.20.50.5-0.60.7-0.40.41.3
Patch foraging total patch changes 0 sec0.72.03.7-1.31.01.61.81.71.41.91.2-1.41.3-0.8
Patch foraging total patch changes 12 sec1.52.04.4-1.61.11.51.71.51.22.11.3-1.01.0-1.2
Patch foraging total patch changes 18 sec1.12.54.4-0.90.91.61.62.01.81.22.1-1.91.90.1
Patch foraging total patch changes 24 sec0.20.71.4-0.50.60.81.00.80.81.01.2-0.90.9-0.5
Patch foraging total patch changes 6 sec1.52.58.4-1.91.81.41.91.10.62.9-0.2-0.70.6-2.1
Patch foraging time to switch 0 sec0.00.00.20.0-0.0-0.1-0.20.1-0.20.1-0.30.2-0.2-0.5
Patch foraging water rate 0 sec0.20.91.8-1.11.11.11.30.70.91.01.1-0.70.60.0
Patch foraging water rate 12 sec0.00.10.4-0.20.70.30.3-0.10.10.00.0-0.10.10.5
Patch foraging water rate 18 sec0.10.10.4-0.10.60.20.40.40.2-0.10.4-0.10.20.6
Patch foraging water rate 24 sec0.40.61.8-0.91.30.91.00.20.70.70.8-0.60.6-0.1
Patch foraging water rate 6 sec0.00.00.10.4-0.1-0.10.1-0.10.0-0.00.3-0.20.20.1
Seeking ratio, delayed vs. immediate footshock0.10.20.7-0.3-0.0-0.1-0.3-0.4-0.4-0.5-0.30.8-0.80.4
Distance traveled before self-admin0.51.13.31.4-0.9-1.1-0.9-1.6-0.8-0.0-0.80.00.1-1.8
Distance traveled after self-admin2.34.06.22.1-2.1-2.5-2.4-2.1-2.3-2.0-1.32.0-1.90.5
Extensor digitorum longus weight1.24.910.1-1.71.72.52.52.62.51.43.2-2.22.10.9
Bone: elastic displacement0.30.41.0-0.80.50.80.81.00.70.50.4-0.30.30.5
Bone: elastic work0.81.12.9-0.30.40.90.91.71.30.21.1-1.31.30.9
Bone: endosteal estimation1.33.25.7-1.01.61.81.81.62.01.61.8-2.42.4-0.9
Bone: endosteal perimeter0.51.23.1-0.10.30.80.71.31.21.20.7-1.71.8-1.0
Epididymis fat weight0.00.10.3-0.40.50.10.2-0.40.0-0.30.10.1-0.10.4
Delta time in closed arm before/after self-admin0.30.30.8-0.20.00.60.20.50.9-0.10.3-0.90.90.1
Delta time in open arm before/after self-admin1.11.32.6-0.90.91.31.31.61.21.01.3-1.01.00.2
Diff in mean of infusions in LGA sessions0.40.71.50.1-0.2-0.7-0.7-0.8-1.0-0.6-1.21.2-1.20.2
Delay discount exponential model param0.30.41.2-0.4-0.00.60.41.00.7-0.21.1-0.50.50.8
Extinction: sum of active levers before priming1.52.34.10.7-1.5-1.7-1.5-1.4-1.9-0.9-1.62.0-2.0-0.1
Active lever presses in extinction session 63.13.17.92.2-2.8-2.3-2.3-1.4-1.6-1.8-0.81.2-1.00.1
Bone: final force0.10.20.80.4-0.6-0.2-0.10.40.1-0.60.6-0.00.10.9
Bone: final moment0.20.41.40.4-0.6-0.0-0.00.70.4-0.81.0-0.30.31.2
Food consumed during 24 hour testing period0.40.72.31.5-1.5-0.8-0.90.1-0.1-1.10.2-0.20.30.8
Glucose0.10.20.9-0.50.10.30.50.10.30.70.1-0.30.2-1.0
Heart weight0.81.32.60.6-0.6-1.2-1.3-1.6-1.4-1.1-1.21.4-1.30.4
Delay discount hyperbolic model param0.30.31.0-0.3-0.30.40.20.90.5-0.51.0-0.30.31.0
Intermittent access intake day 1-15 change0.10.41.41.2-0.5-0.7-0.4-1.0-0.4-0.0-0.4-0.20.2-0.9
Intermittent access intake escalation0.10.31.61.3-0.8-0.6-0.4-0.5-0.1-0.20.0-0.40.4-0.5
Intermittent access intake escalation 20.30.51.21.1-0.7-0.9-0.7-0.9-0.6-0.4-0.60.3-0.4-0.4
Intermitt. access day 1 inactive lever presses0.11.11.80.7-1.2-1.3-1.0-1.0-1.3-0.5-1.41.2-1.3-0.1
Intermitt. access day 15 inactive lever presses0.21.12.50.20.4-0.8-0.3-1.6-1.40.3-1.41.4-1.5-0.6
Intermitt. access escalation Index0.10.40.70.8-0.6-0.7-0.8-0.2-0.5-0.8-0.30.3-0.20.9
Intermittent access day 1 total infusions1.13.47.22.7-2.4-2.3-2.3-2.0-1.8-1.5-1.31.0-0.9-0.9
Intermittent access day 15 total infusions2.04.911.53.4-2.8-2.9-2.7-2.4-2.1-1.9-1.61.2-1.1-0.6
Intermittent access terminal intake (last 3 days)2.84.99.23.0-2.6-2.8-2.6-2.7-2.2-1.7-1.91.4-1.3-1.1
Intermittent access total infusions4.45.211.13.3-2.8-2.9-2.8-2.6-2.3-1.9-1.71.3-1.2-1.0
Intermittent access day 1 locomotion2.44.510.13.2-2.6-2.8-2.6-2.1-2.1-2.0-1.01.4-1.2-0.2
Intermittent access day 15 total locomotion0.72.66.32.5-2.1-2.0-1.8-2.1-1.5-1.2-0.60.9-0.7-0.9
Intermittent access total locomotion3.64.412.83.6-3.0-2.7-2.4-2.2-1.8-1.7-0.60.8-0.6-0.9
Intermittent access standard deviation0.21.12.01.1-0.9-1.3-1.0-1.4-1.1-0.7-1.31.0-1.0-0.6
Left kidney weight0.10.91.31.1-0.1-1.1-0.9-0.9-1.1-1.0-0.71.0-1.01.1
Right kidney weight0.42.55.41.9-1.6-1.7-1.7-0.8-1.2-2.30.11.3-1.22.2
Cocaine induced anxiety0.51.43.40.3-0.2-1.2-0.8-1.8-1.50.2-1.61.2-1.2-1.3
Post-drug Anxiety0.40.42.3-0.10.80.10.2-0.80.00.7-0.2-0.40.4-1.5
Baseline Anxiety1.83.05.0-1.01.42.11.62.12.20.52.1-2.02.00.9
Tail length0.42.14.5-0.90.41.51.41.81.80.82.1-1.81.80.0
Length with tail0.00.00.2-0.40.10.20.30.00.00.20.20.1-0.1-0.0
Length without tail0.63.16.20.6-0.4-1.7-1.4-2.5-2.2-1.1-2.12.5-2.50.2
Times rat made contact with spout1.41.64.42.1-1.9-1.5-1.5-1.1-0.8-0.8-0.9-0.10.1-1.1
Lifetime Intake4.75.813.63.7-3.4-3.1-3.0-2.4-2.2-2.2-1.51.2-1.0-0.8
Liver weight, left2.13.66.6-2.32.62.22.51.11.72.31.3-1.51.4-1.2
Liver weight, right0.81.42.1-0.81.11.21.21.41.30.61.5-1.41.40.5
Locomotor activity0.40.61.01.0-0.8-0.8-0.7-0.8-0.7-1.0-0.10.8-0.70.5
Locomotor testing distance0.71.74.12.0-1.6-1.5-1.4-1.1-0.9-1.80.20.8-0.71.0
Locomotor testing rearing0.82.85.41.4-1.5-2.0-1.9-2.3-2.0-1.4-1.31.7-1.6-0.4
Locomotion in novel chamber1.21.54.61.2-0.4-1.6-1.3-2.1-1.5-0.8-1.21.0-0.9-0.8
Locomotion in novel chamber post-restriction0.10.42.2-1.51.00.70.60.50.30.40.00.1-0.1-0.0
Fecal boli incidents, locomotor time 10.20.51.0-0.51.00.80.80.10.61.00.0-0.70.7-1.0
Change in fecal boli incidents, locomotor task0.70.71.1-0.0-0.8-0.8-1.0-1.0-1.0-0.5-0.91.1-1.0-0.3
Time >=10cm from walls, locomotor time 10.50.62.81.2-1.7-0.8-0.9-0.0-0.2-0.1-0.1-0.30.4-0.9
Bouts of movement, locomotor time 10.50.62.0-1.21.40.50.6-0.9-0.20.8-0.80.5-0.6-0.7
Total resting periods, locomotor time 10.40.51.9-1.11.40.50.5-0.7-0.10.6-0.70.3-0.4-0.5
Rest time, locomotor task time 10.10.10.40.2-0.2-0.1-0.40.20.1-0.6-0.3-0.10.10.4
Distance moved, locomotor task time 10.30.82.40.5-0.6-1.0-0.6-1.5-1.10.2-0.70.8-0.9-1.2
Vertical activity count, locomotor time 10.21.43.41.8-1.8-1.5-1.2-1.5-1.1-0.5-0.10.5-0.5-1.0
Time >=10cm from walls, locomotor time 20.30.93.21.0-1.8-1.2-1.1-0.2-0.9-0.6-0.50.8-0.8-0.0
Bouts of movement, locomotor time 20.41.34.4-2.11.91.11.20.50.11.1-0.60.7-0.90.4
Total resting periods, locomotor time 20.20.93.3-1.81.61.01.00.70.20.6-0.40.6-0.70.9
Rest time, locomotor task time 20.10.20.6-0.70.50.40.10.50.3-0.30.00.1-0.10.8
Distance moved, locomotor task time 20.91.12.80.8-0.8-1.2-0.7-1.6-1.20.4-1.10.8-0.8-1.7
Vertical activity count, locomotor time 20.40.92.51.5-1.6-1.2-0.9-1.0-0.8-0.0-0.10.2-0.1-1.2
Light reinforcement 10.10.71.3-1.01.10.30.4-0.7-0.41.0-0.90.6-0.7-1.2
Light reinforcement 20.10.30.9-0.50.40.10.4-0.3-0.30.9-0.30.3-0.4-1.0
Bone: marrow area1.33.15.8-0.91.51.81.71.62.01.51.9-2.42.4-0.8
Bone: maximum diameter0.10.31.30.4-0.50.0-0.10.80.3-0.40.7-0.20.21.1
Bone: maximum force0.30.51.30.6-0.50.20.21.10.7-0.01.0-1.01.10.4
Bone: maximum moment0.40.81.80.6-0.60.30.21.30.9-0.21.3-1.21.30.7
Mean time between licks in bursts0.10.41.0-0.90.60.50.80.00.21.00.2-0.10.1-1.0
Mean num. licks in bursts0.30.81.6-0.30.50.80.70.71.00.61.3-1.21.3-0.9
Cd content in liver0.20.30.60.7-0.8-0.3-0.40.10.2-0.10.3-0.70.7-0.6
Co content in liver0.30.30.90.20.0-0.4-0.3-0.5-0.6-0.7-0.50.8-0.80.9
Cu content in liver0.20.31.30.4-0.3-0.0-0.20.00.3-0.90.6-0.10.11.1
Fe content in liver0.10.20.6-0.70.40.50.30.50.20.00.00.3-0.30.5
K content in liver0.30.31.5-0.61.20.50.80.30.20.7-0.1-0.10.00.1
Mg content in liver0.20.21.0-0.50.80.40.50.50.10.2-0.00.2-0.31.0
Mn content in liver1.21.43.7-1.81.91.41.60.50.81.50.0-0.50.4-0.7
Na content in liver0.10.10.60.40.1-0.4-0.2-0.8-0.4-0.1-0.20.3-0.4-0.1
Rb content in liver0.10.10.60.10.20.10.2-0.20.20.40.2-0.50.5-0.8
Se content in liver0.50.51.1-0.30.4-0.5-0.0-0.6-1.00.6-1.11.0-1.0-0.9
Sr content in liver6.05.28.3-1.82.12.52.52.22.71.52.9-2.72.70.1
Zn content in liver0.80.92.1-1.21.21.01.21.40.70.90.3-0.30.11.1
Bone: minimum diameter0.20.41.70.6-0.40.10.10.50.6-0.41.3-0.70.80.8
Time in familiar zone, hab. session 10.20.30.70.5-0.2-0.5-0.4-0.5-0.5-0.7-0.20.5-0.50.8
Time in novel zone, hab. session 10.30.30.80.5-0.9-0.3-0.60.90.1-0.6-0.1-0.10.10.9
Total zone transitions, hab. session 10.40.51.91.4-1.0-0.9-0.9-0.5-0.4-1.00.4-0.00.10.4
Total locomotion distance, hab. session 11.82.57.12.7-2.2-1.2-1.50.50.1-2.21.2-0.60.82.2
Locomotion velocity, hab. session 11.21.75.32.3-1.9-1.1-1.3-0.1-0.1-1.90.9-0.30.51.6
Time in familiar zone, hab. session 21.71.92.9-1.21.41.61.51.01.70.91.7-1.71.7-0.4
Time in novel zone, hab. session 22.02.23.51.2-1.3-1.7-1.6-1.0-1.7-1.2-1.91.7-1.80.9
Total zone transitions, hab. session 20.30.41.11.0-1.0-0.6-0.6-0.5-0.2-0.70.90.00.10.1
Total locomotion distance, hab. session 20.91.22.61.6-1.5-0.5-0.60.40.4-1.41.6-0.70.81.3
Locomotion velocity, hab. session 20.91.32.91.7-1.6-0.5-0.70.20.4-1.51.6-0.60.81.3
Novel to familiar place preference ratio0.40.51.3-1.20.90.30.5-0.3-0.30.7-0.60.8-0.9-0.4
Novelty place preference0.40.61.1-1.00.80.20.4-0.4-0.50.8-0.90.9-1.0-0.7
Time in novel zone, NPP test0.50.61.1-1.00.80.10.3-0.5-0.60.7-0.90.9-1.0-0.7
Total zone transitions, NPP test0.30.52.01.0-1.4-0.4-0.5-0.10.2-0.61.1-0.40.6-0.1
Total locomotion distance, NPP test1.92.77.62.5-2.8-1.3-1.7-0.2-0.2-2.41.3-0.10.31.8
Locomotion velocity, NPP test1.82.67.72.5-2.8-1.4-1.8-0.3-0.4-2.31.00.20.01.7
Intraocular pressure0.10.10.30.4-0.4-0.0-0.00.10.2-0.00.3-0.50.5-0.3
Delta distance traveled before/after self-admin0.80.91.60.6-0.8-1.0-0.9-0.6-1.0-1.1-0.31.3-1.21.2
Delta ambulatory time before/after self-admin0.20.41.30.1-0.2-0.4-0.3-0.2-0.6-0.70.20.9-0.81.2
Parametrial fat weight0.30.62.0-0.61.40.20.3-1.1-0.10.8-0.4-0.10.2-1.4
Pavlov. Cond. lever latency0.40.52.1-1.11.40.80.80.40.40.7-0.5-0.20.1-0.0
Pavlov. Cond. magazine entry latency0.20.21.10.7-1.1-0.4-0.4-0.10.0-0.20.1-0.30.4-0.6
Pavlov. Cond. change in total contacts0.50.62.41.1-1.5-0.5-0.60.00.0-0.71.2-0.20.30.2
Pavlov. Cond. index score0.50.73.01.3-1.7-0.8-0.8-0.2-0.2-0.90.7-0.10.20.1
Pavlov. Cond. latency score0.60.72.91.3-1.7-1.0-1.0-0.5-0.5-0.90.30.2-0.10.0
Pavlov. Cond. lever contacts0.40.41.50.9-1.2-0.3-0.40.10.2-0.61.2-0.40.50.3
Pavlov. Cond. magazine entry number0.20.21.1-0.61.00.40.30.20.00.0-0.20.2-0.30.6
Pavlov. Cond. intertrial magazine entries1.11.35.51.1-0.8-0.8-1.1-0.3-0.4-2.20.60.6-0.52.3
Pavlov. Cond. lever-magazine prob. diff.0.60.73.11.3-1.8-0.6-0.7-0.00.0-0.91.0-0.20.40.2
Pavlov. Cond. response bias0.60.83.11.4-1.8-0.6-0.70.20.2-0.81.1-0.50.70.2
Pavlov. Cond. lever latency1.01.42.5-1.51.51.61.31.31.40.90.5-1.01.00.2
Pavlov. Cond. magazine entry latency1.52.13.21.2-1.8-1.8-1.6-1.3-1.7-0.9-1.51.6-1.6-0.4
Pavlov. Cond. change in total contacts0.71.73.11.0-1.1-1.6-1.2-1.8-1.7-0.5-1.01.5-1.5-0.9
Pavlov. Cond. index score1.82.84.31.4-1.6-2.0-1.7-2.0-2.1-0.9-1.61.9-1.8-0.7
Pavlov. Cond. latency score1.82.94.61.6-1.9-2.1-1.9-1.8-2.1-1.1-1.51.8-1.8-0.6
Pavlov. Cond. lever contacts0.81.22.01.2-1.1-1.4-1.1-1.4-1.4-0.7-0.61.1-1.1-0.3
Pavlov. Cond. magazine entry number1.52.03.7-0.40.71.40.91.71.8-0.31.9-1.61.61.7
Pavlov. Cond. intertrial magazine entries0.30.62.5-1.01.61.00.60.00.7-0.20.7-0.40.40.7
Pavlov. Cond. lever-magazine prob. diff.1.93.04.61.4-1.6-2.1-1.8-2.0-2.2-1.0-1.72.0-1.9-0.6
Pavlov. Cond. response bias0.91.32.11.1-1.1-1.5-1.1-1.4-1.4-0.6-0.81.2-1.2-0.5
Time in closed arm before self-admin0.61.01.8-1.31.21.21.30.80.91.01.1-0.70.70.2
Time in closed arm after self-admin1.11.22.1-1.11.21.41.10.91.40.61.2-1.21.20.3
Time in open arm before self-admin5.26.39.82.9-2.7-3.1-3.1-2.3-2.6-2.9-2.02.2-2.11.0
Time in open arm after self-admin1.41.62.71.2-1.4-1.4-1.5-0.5-1.2-1.7-0.81.3-1.21.1
Bone: periosteal estimation0.71.63.1-0.60.91.31.31.51.50.71.8-1.51.50.5
Bone: periosteal perimeter0.20.31.10.9-1.0-0.4-0.60.50.1-0.50.2-0.30.30.7
Bone: post-yield work0.40.72.01.4-1.4-0.6-0.80.50.2-0.20.1-1.01.1-0.6
Progressive ratio test 1 active lever presses3.05.312.33.5-3.4-2.9-3.0-1.9-2.0-2.2-1.11.2-1.0-0.4
Progressive ratio test 1 breakpoint2.95.011.53.4-3.3-2.8-2.9-1.9-2.0-2.1-1.11.2-1.0-0.5
Progressive ratio test 1 inactive lever presses1.23.29.52.9-3.1-2.1-2.2-0.7-1.1-2.20.10.7-0.51.1
Progressive ratio test 2 active lever presses7.210.218.44.3-4.1-4.0-4.1-3.1-3.1-3.4-1.92.4-2.10.2
Progressive ratio test 2 breakpoint7.59.617.54.2-4.0-3.9-4.0-2.9-3.0-3.4-1.82.3-2.00.4
Progressive ratio test 2 inactive lever presses2.06.513.43.7-3.4-3.2-3.2-2.4-2.3-2.7-1.51.7-1.50.3
Incentive Sensitization - Responses1.54.16.22.1-2.3-2.3-2.5-1.7-2.1-2.4-1.32.0-1.91.1
Incentive Sensitization - Breakpoint1.63.75.51.9-2.1-2.2-2.4-1.5-2.0-2.3-1.12.0-1.91.2
Sum of active levers in priming session hrs 5-60.60.51.10.8-1.1-0.9-0.8-0.7-0.9-0.4-0.10.7-0.7-0.1
Progressive ratio0.00.10.5-0.70.40.40.30.20.10.2-0.20.2-0.30.2
Food seeking constrained by brief footshock1.51.93.01.2-1.0-1.5-1.3-1.2-1.5-1.6-0.81.7-1.71.2
Seeking ratio, punishment vs. effort0.51.02.11.4-1.2-1.3-1.1-0.9-1.0-1.2-0.30.8-0.80.6
Retroperitoneal fat weight0.20.73.1-0.01.2-0.4-0.3-1.7-0.8-0.3-1.10.6-0.7-0.4
Reaction time number correct0.31.14.5-2.11.80.80.9-0.0-0.20.9-0.60.9-0.9-0.1
Reaction time mean minus median0.21.62.91.4-1.7-1.5-1.5-0.9-1.1-1.7-0.61.1-1.00.9
Reaction time mean minus median AUC0.10.51.70.8-0.9-0.6-0.8-0.1-0.2-1.30.10.3-0.20.9
Reaction time num false alarms1.01.63.50.4-0.1-1.3-1.0-1.4-1.7-0.8-1.91.8-1.80.2
Reaction time num false alarms AUC0.40.92.3-0.50.7-0.5-0.2-0.8-1.20.0-1.51.4-1.5-0.0
Reaction time trials correct on left0.31.14.5-2.11.80.80.9-0.0-0.20.9-0.60.9-0.9-0.1
Reaction time trials on left0.31.04.1-2.01.70.70.8-0.1-0.30.9-0.70.9-1.0-0.1
Reaction time mean1.63.55.21.4-1.6-2.2-2.0-1.9-2.2-1.4-2.32.2-2.1-0.1
Reaction time mean AUC1.33.05.31.3-1.5-2.0-1.9-1.7-2.1-1.3-2.32.0-1.9-0.2
Median of all reaction times1.92.96.40.8-0.9-1.8-1.6-1.8-2.2-0.9-2.52.2-2.2-0.5
Reaction time omissions0.71.11.90.9-1.4-1.4-1.2-1.1-1.3-0.5-1.01.1-1.0-0.7
Reaction time false alarm rate0.60.81.50.8-0.4-1.1-0.8-1.1-1.2-0.5-1.21.0-1.0-0.3
Reaction time premature initiation rate0.91.33.7-1.71.81.11.50.40.31.9-0.3-0.1-0.0-1.0
Reaction time premature initiations0.82.57.4-2.72.61.31.80.2-0.02.3-0.90.5-0.7-1.2
Std. dev. reaction times1.13.55.01.7-2.0-2.2-2.2-1.9-2.0-2.0-1.72.0-1.90.5
Reaction time trials completed0.31.04.1-2.01.70.70.8-0.1-0.30.9-0.70.9-1.0-0.1
Reaction time trials AUC0.20.93.1-1.81.40.50.6-0.2-0.40.6-0.71.1-1.20.0
Run reversals in cocaine runway, females0.20.21.20.10.20.20.20.20.2-0.60.90.00.01.1
Run reversals in cocaine runway, males1.41.63.01.7-1.7-0.2-0.71.30.8-1.31.5-1.01.11.6
Latency to leave start box in cocaine runway1.11.54.5-2.11.71.61.11.11.30.70.5-0.90.9-0.1
Latency to leave start box in cocaine runway, F0.91.15.1-2.31.51.31.00.70.80.70.1-0.20.1-0.2
Latency to leave start box in cocaine runway, M0.60.61.6-0.30.80.80.30.61.0-0.00.6-1.21.30.2
Std. dev. time between licks in bursts0.10.21.00.4-0.4-0.4-0.4-1.0-0.3-0.60.50.3-0.2-0.2
Total sessions with >9 infusions4.55.613.93.7-3.7-3.0-3.0-2.0-2.0-2.4-0.81.1-0.9-0.2
Short access day 1 total inactive lever presses0.61.22.71.2-1.6-1.4-1.2-1.2-1.2-0.7-0.50.9-0.7-0.7
Short access day 10 total inactive lever presses0.10.62.1-1.51.00.40.6-0.5-0.30.7-0.60.9-1.0-0.3
Short access day 1 total infusions3.26.215.83.5-4.0-3.1-3.2-2.3-2.1-2.5-1.31.3-1.1-0.5
Short access day 10 total infusions2.13.49.43.1-2.9-2.3-2.3-1.6-1.5-1.4-1.00.6-0.4-1.0
Short access total infusions3.85.314.43.8-3.8-2.9-3.0-1.8-1.6-2.4-0.70.6-0.4-0.4
Short access day 1 locomotion2.94.811.93.3-3.5-2.9-2.7-1.7-2.0-2.1-1.01.2-1.0-0.2
Short access day 10 total locomotion0.41.54.72.2-1.6-1.6-1.2-1.4-1.0-0.6-0.30.2-0.2-0.9
Short access total locomotion4.06.013.73.7-3.5-3.3-2.9-2.2-2.4-2.2-1.11.6-1.4-0.2
One hour access (0.3 mA shock)2.73.27.72.8-2.2-2.3-2.3-1.7-1.6-2.1-1.00.9-0.80.1
Compulsive drug intake0.81.12.1-1.10.71.21.01.11.30.21.4-1.11.10.8
One hour access (shock baseline)2.87.312.63.6-3.0-3.4-3.3-2.8-2.9-2.2-2.62.1-2.0-0.7
Social response proportion1.62.18.6-0.30.5-0.6-0.3-1.8-1.31.5-2.20.7-0.9-2.9
Social responses2.33.06.41.2-0.9-1.9-1.6-2.4-2.1-0.1-2.51.6-1.7-1.6
Social time1.93.16.00.8-0.7-1.8-1.6-1.8-2.3-1.0-2.52.4-2.40.2
Soleus weight0.92.57.31.6-0.90.2-0.31.51.3-1.72.3-1.51.72.7
Bone: stiffness0.20.41.51.1-1.2-0.7-0.7-0.2-0.2-0.60.0-0.10.2-0.0
Tibialis anterior weight0.82.97.4-1.31.41.91.81.72.00.42.7-1.71.81.0
Time to tail flick, vehicle, before self-admin0.00.00.1-0.20.10.10.10.10.00.1-0.10.1-0.10.3
Time to tail flick, vehicle, after self-admin0.10.20.7-0.2-0.30.1-0.10.80.1-0.5-0.10.2-0.20.9
Time to tail flick, test, before self-admin0.20.30.80.8-0.9-0.7-0.5-0.1-0.4-0.40.20.1-0.10.4
Time to tail flick, test, after self-admin2.12.23.2-1.11.51.81.81.61.71.51.5-1.61.60.2
Delta time to tail flick, vehicle, before/after SA0.40.52.50.1-0.5-0.1-0.40.70.1-1.20.40.3-0.31.6
Delta time to tail flick, test, before/after SA0.50.61.2-0.71.01.11.00.80.80.60.7-0.60.50.5
Tibia length2.26.113.5-2.12.4-0.60.3-2.6-2.71.3-3.63.4-3.7-1.5
Ambulatory time before self-admin0.31.13.31.5-1.3-1.1-1.0-1.3-0.5-0.1-0.4-0.30.5-1.8
Ambulatory time after self-admin1.01.62.91.6-1.4-1.7-1.4-1.7-1.4-0.8-0.70.8-0.7-0.8
Bone: tissue strength1.51.54.82.1-2.2-0.9-1.00.50.4-1.01.1-1.11.30.3
Total heroin consumption2.83.37.4-0.1-0.4-1.7-1.2-2.1-2.5-0.1-2.52.7-2.7-0.7
Bone: trabecular number1.01.93.1-1.10.91.61.61.81.71.21.3-1.61.5-0.0
Bone: trabecular spacing0.30.40.70.3-0.6-0.5-0.7-0.3-0.6-0.8-0.20.8-0.70.7
Bone: trabecular thickness0.00.10.1-0.2-0.2-0.1-0.1-0.1-0.2-0.1-0.40.4-0.4-0.1
Bone: trabecular tissue density0.30.51.90.7-0.9-0.1-0.60.00.4-1.40.9-0.40.41.1
Water consumed over 24 hours0.10.21.00.1-0.2-0.3-0.1-0.0-0.40.4-1.00.2-0.3-0.5
Number of responses in last shaping day0.20.20.80.9-0.8-0.5-0.6-0.3-0.2-0.6-0.0-0.00.10.2