Hub : Genes

Inf2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	isoform ratio	XR_005506359.1	0.02	0.02	4.0e-03	0.01	0.01	0	0.01	1.6e-02	1.1e-02	1.7e-01	7.4e-03
2	Liver	gene expression	Inf2	0.12	0.07	0.0e+00	0.13	0.14	0.13	0.14	5.6e-14	1.2e-15	1.1e-14	4.4e-15
3	PL	gene expression	Inf2	0.04	0.03	5.5e-05	0.04	0.04	0.04	0.04	7.0e-05	1.4e-05	6.8e-05	3.1e-05
4	LHb	isoform ratio	XR_005506359.1	0.11	0.1	9.5e-03	0.06	0.07	0.05	0.07	1.3e-02	9.3e-03	2.8e-02	1.0e-02
5	Brain	isoform ratio	XM_039113408.1	0.04	0.03	5.7e-03	0.03	0.02	0.02	0.03	4.4e-04	4.6e-03	2.6e-03	2.1e-03
6	Eye	mRNA stability	Inf2	0.35	0.19	2.9e-04	0.24	0.21	0.26	0.25	1.2e-04	3.4e-04	6.8e-05	9.9e-05
7	IL	gene expression	Inf2	0.21	0.15	2.8e-04	0.18	0.14	0.15	0.17	4.4e-05	2.9e-04	2.3e-04	8.5e-05
8	OFC	isoform ratio	XM_039113404.1	0.14	0.1	8.9e-04	0.11	0.1	0.08	0.07	1.7e-03	2.4e-03	5.2e-03	8.7e-03
9	Adipose	gene expression	Inf2	0.09	0.07	1.7e-08	0.06	0.06	0.06	0.06	1.7e-07	5.7e-07	4.7e-07	2.6e-07
10	NAcc	isoform ratio	XR_005506359.1	0.04	0.04	1.0e-03	0.02	0.02	0.02	0.02	2.7e-03	9.0e-04	2.5e-03	2.4e-03
11	NAcc	gene expression	Inf2	0.11	0.07	1.0e-08	0.06	0.07	0.06	0.06	9.8e-08	2.7e-08	6.7e-08	1.3e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bone: apparent density	0.0	0.0	0.1	-0.2	-0.1	0.0	-0.0	-0.1	-0.1	-0.3	-0.3	0.2	0.1	0.2
Area under the delay curve	0.2	0.2	0.5	0.7	0.7	-0.6	0.6	0.2	-0.3	0.2	0.2	-0.4	0.0	-0.2
BMI with tail	2.3	7.5	8.3	2.6	2.7	-2.7	2.7	2.7	-2.9	2.8	2.8	-2.7	2.7	2.7
BMI without tail	0.5	1.0	1.7	1.3	1.2	-1.2	1.2	1.0	-1.2	0.8	0.8	-0.4	0.9	0.8
Body weight	0.7	3.0	5.8	-2.4	-2.1	2.0	-2.0	-1.9	1.4	-1.6	-1.6	1.5	-1.3	-0.8
Weight adjusted by age	0.3	0.4	0.5	-0.5	-0.6	0.6	-0.6	-0.7	0.6	-0.7	-0.7	0.3	-0.7	-0.6
Bone surface	0.1	0.1	0.4	0.7	0.4	-0.3	0.3	0.3	-0.2	-0.3	-0.3	-0.0	0.0	-0.0
Bone volume	0.0	0.1	0.2	0.5	0.3	-0.2	0.2	0.1	-0.1	-0.5	-0.5	0.2	-0.1	-0.1
Breakpoint value in progressive ratio session	0.4	0.5	1.0	0.2	0.3	-0.4	0.4	0.6	-0.6	0.9	0.9	-1.0	0.8	0.9
Number of licking bursts	0.2	0.2	0.8	0.9	0.7	-0.6	0.6	0.5	-0.2	0.2	0.2	-0.3	0.0	-0.2
Context. condit. distance diff. score	3.7	4.5	5.2	-2.1	-2.2	2.3	-2.3	-2.0	2.2	-2.1	-2.1	1.9	-2.1	-1.9
Locomotion velocity, session 1	0.1	0.1	0.3	-0.5	-0.4	0.4	-0.5	-0.4	0.4	-0.2	-0.2	0.2	-0.4	-0.3
Locomotion distance, session 1	0.6	0.7	1.1	0.4	0.7	-0.7	0.7	0.7	-0.9	0.9	0.9	-1.0	1.0	1.0
Locomotion velocity, session 2	0.0	0.0	0.1	0.4	0.3	-0.2	0.2	0.2	0.0	0.1	0.1	-0.1	-0.1	-0.2
Locomotion distance, session 2	0.3	0.4	0.8	0.9	0.7	-0.7	0.7	0.6	-0.6	0.4	0.4	-0.5	0.4	0.4
Locomotion velocity, session 3	0.1	0.1	0.2	0.1	0.2	-0.2	0.2	0.2	-0.4	0.3	0.3	-0.4	0.4	0.5
Locomotion distance, session 3	0.0	0.0	0.0	0.0	0.0	0.0	-0.0	-0.0	0.1	-0.1	-0.1	0.0	-0.1	-0.1
Stereotopy head waving bouts, day 3	0.0	0.0	0.1	-0.1	-0.2	0.2	-0.2	-0.3	0.2	-0.2	-0.2	0.3	-0.1	-0.2
Stereotopy head waving duration, day 3	0.1	0.1	0.3	-0.2	-0.3	0.3	-0.3	-0.4	0.3	-0.4	-0.4	0.5	-0.4	-0.4
Locomotion velocity, session 7	0.3	0.3	0.6	-0.0	0.2	-0.3	0.3	0.3	-0.4	0.8	0.8	-0.7	0.7	0.8
Locomotion distance, session 7	0.7	0.9	1.1	1.0	1.0	-1.0	1.0	1.0	-0.8	1.1	1.1	-1.0	0.8	0.8
Stereotopy head waving bouts, day 7	1.8	2.0	3.2	-1.8	-1.6	1.5	-1.5	-1.6	1.2	-1.4	-1.4	1.4	-1.1	-0.9
Stereotopy head waving duration, day 7	0.7	0.9	1.9	-1.4	-1.1	1.0	-1.0	-1.1	0.7	-0.9	-0.9	0.8	-0.5	-0.4
Locomotion velocity, session 8	1.2	1.5	2.2	-1.5	-1.5	1.4	-1.4	-1.3	1.0	-1.2	-1.2	1.1	-0.9	-0.6
Locomotion distance, session 8	0.3	0.5	0.7	-0.8	-0.8	0.8	-0.8	-0.6	0.7	-0.8	-0.8	0.5	-0.6	-0.4
Degree of sensitization distance	0.3	0.3	0.4	0.6	0.6	-0.6	0.6	0.5	-0.4	0.6	0.6	-0.6	0.5	0.4
Degree of sensitization stereotypy	0.5	0.5	1.2	-1.1	-0.9	0.8	-0.8	-0.8	0.5	-0.7	-0.7	0.6	-0.4	-0.3
Conditioned locomotion	1.3	1.6	2.1	-1.4	-1.4	1.4	-1.4	-1.3	1.2	-1.1	-1.1	1.2	-1.1	-1.1
Cocaine response after cond. corrected	0.8	0.9	2.1	0.2	0.6	-0.7	0.7	0.8	-1.2	1.0	1.0	-1.0	1.3	1.4
Cocaine response after cond. not corrected	2.1	2.3	3.9	0.8	1.2	-1.3	1.3	1.4	-1.8	1.5	1.5	-1.5	1.9	2.0
Cocaine response before conditioning	1.7	2.0	3.0	1.7	1.6	-1.6	1.6	1.5	-1.4	1.3	1.3	-1.2	1.2	1.1
Saline control response	0.0	0.0	0.1	-0.3	-0.2	0.2	-0.2	-0.2	-0.1	-0.1	-0.1	0.2	0.1	0.2
Bone: connectivity density	0.3	0.5	0.6	-0.7	-0.8	0.8	-0.8	-0.6	0.7	-0.8	-0.8	0.7	-0.6	-0.5
Bone: cortical apparent density	6.1	8.0	9.1	-2.6	-2.7	2.8	-2.8	-2.8	2.9	-2.9	-2.9	2.9	-2.9	-3.0
Bone: cortical area	0.2	0.3	0.7	-0.5	-0.5	0.5	-0.5	-0.5	0.4	-0.8	-0.8	0.5	-0.5	-0.6
Bone: cortical porosity	0.4	0.5	0.6	-0.5	-0.6	0.7	-0.7	-0.6	0.7	-0.7	-0.7	0.8	-0.8	-0.6
Bone: cortical porosity	0.1	0.1	0.1	-0.3	-0.4	0.4	-0.4	-0.2	0.2	-0.2	-0.2	0.3	-0.2	0.0
Bone: cortical thickness	0.2	0.4	1.1	-1.0	-0.7	0.6	-0.6	-0.6	0.3	-0.7	-0.7	0.4	-0.2	-0.2
Bone: cortical thickness	1.0	1.1	1.7	-1.1	-1.0	1.0	-1.0	-1.2	0.8	-1.3	-1.3	1.2	-0.9	-0.9
Bone: cortical tissue density	6.2	8.2	9.5	-2.6	-2.7	2.8	-2.8	-2.8	2.9	-2.9	-2.9	2.9	-3.0	-3.1
Condit. Reinf. active minus inactive responses	0.6	0.7	1.0	0.4	0.7	-0.8	0.8	0.7	-0.9	0.9	0.9	-1.0	1.0	1.0
Condit. Reinf. active-inactive response ratio	2.8	3.0	3.8	1.4	1.6	-1.6	1.6	1.7	-1.7	1.9	1.9	-1.9	1.8	1.8
Condit. Reinf. active responses	0.1	0.2	0.5	-0.3	0.1	-0.2	0.2	0.2	-0.5	0.4	0.4	-0.5	0.6	0.7
Condit. Reinf. inactive responses	1.6	1.9	3.1	-1.8	-1.5	1.5	-1.5	-1.5	1.2	-1.3	-1.3	1.4	-1.0	-1.0
Incentive salience index mean	0.5	0.6	1.5	-0.0	0.4	-0.6	0.6	0.5	-0.9	0.8	0.8	-0.9	1.1	1.2
Condit. Reinf. lever presses	0.1	0.2	0.7	-0.3	0.0	-0.1	0.1	0.1	-0.5	0.4	0.4	-0.5	0.7	0.8
Condit. Reinf. active minus inactive responses	1.0	1.2	1.6	-0.8	-1.0	1.0	-1.0	-1.0	1.2	-1.3	-1.3	1.1	-1.2	-1.2
Condit. Reinf. active-inactive response ratio	0.8	0.8	1.3	-0.4	-0.7	0.8	-0.8	-0.8	1.1	-0.9	-0.9	1.0	-1.1	-1.2
Condit. Reinf. active responses	0.1	0.2	0.5	-0.2	-0.3	0.3	-0.3	-0.4	0.4	-0.7	-0.7	0.6	-0.5	-0.5
Condit. Reinf. inactive responses	0.3	0.3	0.6	0.4	0.6	-0.7	0.7	0.5	-0.7	0.3	0.3	-0.5	0.7	0.7
Condit. Reinf. lever presses	0.7	1.0	2.2	1.5	1.2	-1.1	1.1	1.1	-0.8	0.8	0.8	-0.8	0.6	0.5
Condit. Reinf. lever reinforcers received	0.2	0.3	0.7	-0.3	-0.4	0.4	-0.4	-0.5	0.6	-0.8	-0.8	0.7	-0.7	-0.6
Conditioned reinforcement - actives	1.8	1.8	2.3	-1.0	-1.2	1.3	-1.3	-1.3	1.4	-1.4	-1.4	1.5	-1.4	-1.5
Conditioned reinforcement - inactives	0.5	0.6	0.9	-1.0	-0.7	0.7	-0.7	-0.9	0.6	-0.8	-0.8	0.9	-0.7	-0.7
Conditioned locomotion	0.2	0.2	0.6	0.4	0.3	-0.4	0.4	0.3	-0.6	0.5	0.5	-0.5	0.6	0.8
Patch foraging indifference point 0 sec	4.2	6.8	9.7	-3.1	-3.0	2.9	-2.9	-2.7	2.4	-2.4	-2.4	2.5	-2.1	-1.9
Patch foraging indifference point AUC	2.1	2.4	6.1	-2.5	-2.1	1.9	-1.9	-1.5	1.2	-1.1	-1.1	1.0	-0.8	-0.5
Delay disc. indifference point, 0s delay	0.3	0.4	0.7	-0.8	-0.6	0.6	-0.6	-0.8	0.4	-0.6	-0.6	0.6	-0.5	-0.4
Delay disc. indifference point, 16s delay	0.3	0.3	0.8	0.9	0.8	-0.7	0.7	0.6	-0.3	0.5	0.5	-0.7	0.1	-0.2
Delay disc. indifference point, 2s delay	0.9	1.0	2.5	1.6	1.5	-1.3	1.3	0.7	-0.8	0.7	0.7	-0.8	0.4	0.0
Delay disc. indifference point, 24s delay	0.4	0.3	0.7	0.8	0.8	-0.8	0.8	0.4	-0.6	0.4	0.4	-0.6	0.3	0.1
Delay disc. indifference point, 4s delay	0.3	0.3	1.0	0.2	0.0	0.1	-0.1	-0.6	0.5	-0.6	-0.6	0.5	-0.8	-1.0
Delay disc. indifference point, 8s delay	0.0	0.1	0.2	0.3	0.4	-0.3	0.3	0.1	-0.2	0.0	0.0	-0.1	-0.0	-0.1
Indifference point function ln k	1.5	2.0	3.1	-0.9	-1.2	1.2	-1.2	-1.4	1.4	-1.5	-1.5	1.8	-1.6	-1.6
Indifference point function log k	1.5	2.0	3.1	-0.9	-1.2	1.2	-1.2	-1.4	1.4	-1.5	-1.5	1.8	-1.6	-1.6
Patch foraging total patch changes 0 sec	4.9	7.9	11.5	-3.4	-3.3	3.2	-3.2	-2.9	2.6	-2.5	-2.5	2.7	-2.3	-2.0
Patch foraging total patch changes 12 sec	3.1	4.1	5.2	-2.3	-2.3	2.2	-2.2	-2.1	2.0	-1.8	-1.8	1.6	-1.9	-1.8
Patch foraging total patch changes 18 sec	1.2	1.5	3.4	-1.8	-1.6	1.5	-1.5	-1.3	0.8	-1.1	-1.1	1.0	-0.8	-0.7
Patch foraging total patch changes 24 sec	0.4	0.5	1.3	-1.2	-1.0	0.8	-0.8	-0.7	0.4	-0.5	-0.5	0.4	-0.3	-0.1
Patch foraging total patch changes 6 sec	2.0	3.0	7.3	-2.7	-2.4	2.2	-2.2	-1.7	1.4	-1.2	-1.2	1.2	-0.9	-0.6
Patch foraging time to switch 0 sec	9.7	14.9	18.2	4.1	4.3	-4.2	4.2	4.0	-3.9	3.6	3.6	-3.7	3.5	3.3
Patch foraging water rate 0 sec	16.1	25.8	29.8	-5.1	-5.5	5.4	-5.4	-5.2	5.2	-4.8	-4.8	5.0	-4.8	-4.7
Patch foraging water rate 12 sec	9.6	14.8	17.9	-3.1	-3.6	3.8	-3.7	-3.9	4.1	-3.7	-3.7	4.0	-4.2	-4.2
Patch foraging water rate 18 sec	5.0	6.8	7.8	-2.2	-2.6	2.6	-2.6	-2.8	2.7	-2.6	-2.6	2.7	-2.7	-2.7
Patch foraging water rate 24 sec	4.1	5.7	6.4	-1.8	-2.4	2.4	-2.4	-2.4	2.5	-2.4	-2.4	2.5	-2.5	-2.5
Patch foraging water rate 6 sec	4.6	6.7	7.2	-2.4	-2.7	2.7	-2.7	-2.7	2.6	-2.5	-2.5	2.6	-2.5	-2.5
Seeking ratio, delayed vs. immediate footshock	0.3	0.3	0.5	-0.6	-0.7	0.7	-0.7	-0.7	0.4	-0.5	-0.5	0.5	-0.6	-0.5
Distance traveled before self-admin	0.6	0.7	1.0	1.0	0.9	-0.9	0.9	0.7	-0.8	0.8	0.8	-1.0	0.7	0.5
Distance traveled after self-admin	0.5	0.6	0.9	-0.4	-0.6	0.6	-0.6	-0.9	0.7	-0.8	-0.8	0.8	-0.9	-1.0
Extensor digitorum longus weight	7.6	29.9	38.0	-6.2	-6.1	6.0	-6.0	-5.7	5.3	-5.1	-5.1	5.0	-4.9	-4.4
Bone: elastic displacement	0.5	0.6	1.3	-0.2	-0.3	0.4	-0.4	-0.7	0.7	-1.0	-1.0	0.9	-0.9	-1.1
Bone: elastic work	0.1	0.2	0.6	0.7	0.4	-0.2	0.2	0.1	0.2	-0.3	-0.3	0.2	-0.5	-0.7
Bone: endosteal estimation	0.2	0.4	2.2	1.5	0.9	-0.7	0.7	0.6	-0.1	0.1	0.1	-0.2	-0.3	-0.4
Bone: endosteal perimeter	0.0	0.1	0.5	0.7	0.4	-0.3	0.3	0.4	-0.2	-0.1	-0.1	-0.2	0.0	-0.1
Epididymis fat weight	3.4	7.9	9.3	2.4	2.7	-2.7	2.7	2.8	-3.0	2.9	2.9	-2.6	2.9	3.1
Delta time in closed arm before/after self-admin	0.0	0.0	0.1	0.0	-0.2	0.2	-0.2	-0.4	0.1	-0.1	-0.1	0.2	-0.1	0.0
Delta time in open arm before/after self-admin	0.4	0.4	1.2	-1.1	-0.7	0.7	-0.7	-0.8	0.4	-0.6	-0.6	0.6	-0.3	-0.2
Diff in mean of infusions in LGA sessions	0.3	0.3	0.8	-0.5	-0.2	0.1	-0.1	0.3	-0.3	0.7	0.7	-0.6	0.7	0.9
Delay discount exponential model param	0.1	0.1	0.4	-0.6	-0.6	0.5	-0.5	-0.1	0.2	-0.1	-0.1	0.2	0.1	0.3
Extinction: sum of active levers before priming	0.2	0.2	0.4	0.0	0.3	-0.3	0.3	0.3	-0.3	0.5	0.5	-0.6	0.5	0.5
Active lever presses in extinction session 6	1.6	1.5	2.2	-1.3	-1.3	1.3	-1.3	-1.1	1.5	-1.1	-1.1	1.0	-1.3	-1.2
Bone: final force	0.2	0.3	1.0	0.3	-0.2	0.3	-0.3	-0.2	0.6	-0.7	-0.7	0.5	-0.8	-1.0
Bone: final moment	0.3	0.4	1.1	0.1	-0.3	0.4	-0.4	-0.4	0.7	-0.7	-0.7	0.7	-0.9	-1.0
Food consumed during 24 hour testing period	0.6	0.7	1.1	-1.0	-1.0	0.9	-0.9	-1.0	0.7	-0.9	-0.9	0.9	-0.6	-0.5
Glucose	0.3	0.4	0.8	-0.3	-0.3	0.4	-0.4	-0.6	0.5	-0.8	-0.8	0.9	-0.7	-0.9
Heart weight	0.0	0.0	0.1	0.3	0.1	-0.1	0.1	0.1	0.1	-0.0	-0.0	-0.2	-0.2	-0.3
Delay discount hyperbolic model param	0.2	0.2	0.5	-0.7	-0.7	0.6	-0.6	-0.2	0.3	-0.3	-0.3	0.4	0.0	0.2
Intermittent access intake day 1-15 change	1.7	1.6	1.8	1.1	1.3	-1.3	1.3	1.3	-1.3	1.3	1.3	-1.1	1.3	1.2
Intermittent access intake escalation	1.6	1.6	1.8	1.1	1.3	-1.3	1.3	1.3	-1.3	1.3	1.3	-1.0	1.3	1.2
Intermittent access intake escalation 2	0.4	0.4	0.5	0.4	0.6	-0.6	0.6	0.6	-0.7	0.7	0.7	-0.7	0.7	0.7
Intermitt. access day 1 inactive lever presses	3.2	3.4	4.5	-2.1	-1.9	1.9	-1.9	-1.7	1.9	-1.8	-1.8	1.7	-1.8	-1.7
Intermitt. access day 15 inactive lever presses	1.1	1.2	1.5	-1.2	-1.0	1.0	-1.0	-1.0	1.1	-1.1	-1.1	1.2	-1.2	-1.2
Intermitt. access escalation Index	0.3	0.2	0.4	0.0	-0.3	0.4	-0.4	-0.5	0.5	-0.5	-0.5	0.6	-0.6	-0.6
Intermittent access day 1 total infusions	0.1	0.1	0.5	-0.1	0.1	-0.1	0.1	0.3	-0.4	0.3	0.3	-0.5	0.5	0.7
Intermittent access day 15 total infusions	1.5	1.6	2.1	1.0	1.2	-1.3	1.3	1.3	-1.4	1.3	1.3	-1.2	1.4	1.4
Intermittent access terminal intake (last 3 days)	1.9	2.0	2.7	0.9	1.4	-1.4	1.4	1.5	-1.6	1.4	1.4	-1.4	1.6	1.5
Intermittent access total infusions	0.4	0.4	0.8	0.2	0.5	-0.6	0.6	0.7	-0.8	0.6	0.6	-0.7	0.8	0.9
Intermittent access day 1 locomotion	0.3	0.3	0.7	0.5	0.4	-0.4	0.4	0.6	-0.7	0.5	0.5	-0.6	0.7	0.8
Intermittent access day 15 total locomotion	0.1	0.1	0.1	0.3	0.2	-0.2	0.2	0.3	-0.3	0.2	0.2	-0.2	0.2	0.3
Intermittent access total locomotion	0.1	0.2	0.5	0.0	0.1	-0.2	0.2	0.4	-0.6	0.3	0.3	-0.4	0.6	0.7
Intermittent access standard deviation	3.1	3.3	5.4	1.1	1.4	-1.6	1.6	1.7	-2.1	1.9	1.9	-1.8	2.2	2.3
Left kidney weight	2.0	5.7	7.8	-2.5	-2.8	2.7	-2.7	-2.4	2.3	-2.3	-2.3	2.1	-2.2	-1.8
Right kidney weight	1.3	3.7	4.6	-1.8	-2.1	2.1	-2.1	-1.9	1.9	-1.9	-1.9	1.7	-1.9	-1.6
Cocaine induced anxiety	1.3	1.5	2.7	-0.7	-1.1	1.1	-1.1	-1.1	1.4	-1.2	-1.2	1.0	-1.4	-1.6
Post-drug Anxiety	0.8	0.9	1.5	-0.6	-0.8	0.9	-0.9	-0.8	1.1	-0.9	-0.9	0.8	-1.0	-1.2
Baseline Anxiety	1.4	1.5	2.0	0.9	1.1	-1.2	1.2	1.1	-1.4	1.2	1.2	-1.1	1.4	1.4
Tail length	4.8	14.7	16.5	-4.1	-4.0	3.9	-3.9	-4.0	3.5	-4.0	-4.0	4.0	-3.4	-3.1
Length with tail	7.1	26.1	35.4	-6.0	-5.7	5.5	-5.5	-5.3	4.7	-5.0	-5.0	4.8	-4.4	-3.8
Length without tail	3.3	7.3	12.8	-3.6	-3.3	3.1	-3.2	-2.8	2.6	-2.3	-2.3	1.9	-2.2	-1.8
Times rat made contact with spout	0.1	0.1	0.2	-0.5	-0.3	0.3	-0.3	-0.3	0.2	-0.1	-0.1	0.1	-0.0	-0.1
Lifetime Intake	0.1	0.1	0.3	0.2	0.4	-0.4	0.4	0.4	-0.5	0.3	0.3	-0.3	0.4	0.4
Liver weight, left	1.9	3.1	3.8	-1.9	-1.9	1.9	-1.9	-1.8	1.7	-1.5	-1.5	1.8	-1.6	-1.6
Liver weight, right	0.1	0.1	0.6	-0.8	-0.5	0.4	-0.4	-0.3	0.0	0.1	0.1	-0.4	0.2	0.4
Locomotor activity	0.2	0.3	0.3	-0.4	-0.5	0.5	-0.5	-0.6	0.5	-0.5	-0.5	0.4	-0.6	-0.6
Locomotor testing distance	0.2	0.4	0.8	-0.4	-0.5	0.6	-0.6	-0.6	0.7	-0.5	-0.5	0.5	-0.8	-0.9
Locomotor testing rearing	2.1	3.3	4.7	1.8	1.8	-1.8	1.7	1.9	-1.7	2.0	2.0	-2.2	1.6	1.4
Locomotion in novel chamber	6.3	7.8	9.3	-2.3	-2.5	2.6	-2.6	-2.6	2.9	-3.1	-3.1	2.9	-3.0	-3.0
Locomotion in novel chamber post-restriction	0.0	0.0	0.1	0.4	0.1	-0.1	0.1	0.1	0.2	-0.1	-0.1	0.2	-0.2	-0.2
Fecal boli incidents, locomotor time 1	2.1	2.3	4.1	0.8	1.2	-1.3	1.3	1.3	-1.6	1.7	1.7	-1.7	1.9	2.0
Change in fecal boli incidents, locomotor task	3.3	3.1	4.4	-1.4	-1.6	1.7	-1.7	-1.6	1.7	-2.1	-2.1	2.1	-1.8	-1.6
Time >=10cm from walls, locomotor time 1	0.4	0.4	1.4	-1.0	-0.6	0.4	-0.4	0.0	-0.3	0.4	0.4	-0.4	0.8	1.2
Bouts of movement, locomotor time 1	1.8	2.0	2.7	1.0	1.4	-1.4	1.4	1.2	-1.7	1.4	1.4	-1.4	1.5	1.5
Total resting periods, locomotor time 1	1.6	1.8	2.5	1.0	1.4	-1.4	1.4	1.2	-1.6	1.3	1.3	-1.3	1.4	1.3
Rest time, locomotor task time 1	0.1	0.1	0.2	0.3	0.4	-0.4	0.4	-0.0	-0.3	-0.2	-0.2	0.2	0.0	-0.2
Distance moved, locomotor task time 1	0.4	0.5	1.3	1.2	0.7	-0.6	0.6	0.9	-0.1	0.7	0.7	-0.8	0.1	0.0
Vertical activity count, locomotor time 1	0.2	0.2	0.7	0.4	-0.1	0.2	-0.2	0.1	0.6	-0.2	-0.2	0.0	-0.6	-0.9
Time >=10cm from walls, locomotor time 2	0.6	0.6	2.1	-1.5	-1.1	1.0	-1.0	-0.6	0.6	-0.4	-0.4	0.5	-0.3	-0.1
Bouts of movement, locomotor time 2	1.7	1.9	3.7	-0.6	-0.8	0.9	-0.9	-1.4	1.3	-1.6	-1.6	1.7	-1.7	-1.9
Total resting periods, locomotor time 2	1.4	1.4	3.1	-0.4	-0.6	0.7	-0.7	-1.3	1.1	-1.4	-1.4	1.4	-1.5	-1.8
Rest time, locomotor task time 2	0.1	0.1	0.3	-0.1	-0.1	0.1	-0.1	-0.4	0.3	-0.5	-0.5	0.1	-0.4	-0.6
Distance moved, locomotor task time 2	0.5	0.5	0.9	0.9	0.6	-0.6	0.6	0.9	-0.5	0.9	0.9	-0.9	0.5	0.4
Vertical activity count, locomotor time 2	0.0	0.0	0.1	-0.0	-0.2	0.2	-0.2	0.0	0.3	-0.0	-0.0	0.3	-0.2	-0.3
Light reinforcement 1	0.0	0.0	0.0	-0.0	-0.1	0.1	-0.1	-0.1	0.1	-0.2	-0.2	0.2	-0.1	-0.1
Light reinforcement 2	2.1	2.8	3.1	1.5	1.6	-1.6	1.7	1.7	-1.6	1.8	1.8	-1.7	1.7	1.7
Bone: marrow area	0.2	0.4	2.2	1.5	0.9	-0.7	0.7	0.6	-0.1	0.1	0.1	-0.1	-0.3	-0.5
Bone: maximum diameter	0.1	0.3	0.4	0.5	0.6	-0.6	0.6	0.5	-0.7	0.2	0.2	-0.5	0.6	0.4
Bone: maximum force	0.1	0.2	0.6	0.1	-0.3	0.3	-0.3	-0.3	0.5	-0.6	-0.6	0.4	-0.7	-0.8
Bone: maximum moment	0.1	0.2	0.5	-0.1	-0.4	0.4	-0.4	-0.4	0.5	-0.6	-0.6	0.5	-0.6	-0.7
Mean time between licks in bursts	0.4	0.5	0.8	0.9	0.8	-0.8	0.8	0.8	-0.6	0.7	0.7	-0.6	0.6	0.6
Mean num. licks in bursts	0.3	0.3	1.2	-1.1	-0.8	0.7	-0.7	-0.7	0.2	-0.3	-0.3	0.4	-0.0	0.2
Cd content in liver	2.3	2.5	3.5	-1.0	-1.4	1.5	-1.5	-1.5	1.8	-1.7	-1.7	1.6	-1.9	-1.7
Co content in liver	1.4	1.6	1.9	-1.3	-1.3	1.3	-1.4	-1.3	1.4	-1.2	-1.2	1.1	-1.3	-1.2
Cu content in liver	2.4	3.0	3.6	1.9	1.8	-1.7	1.7	1.8	-1.5	1.9	1.9	-1.7	1.5	1.4
Fe content in liver	0.7	0.8	1.5	1.2	1.0	-1.0	1.0	1.0	-0.7	0.9	0.9	-0.9	0.7	0.5
K content in liver	0.2	0.2	0.5	-0.7	-0.6	0.5	-0.5	-0.5	0.2	-0.2	-0.2	0.2	-0.1	0.1
Mg content in liver	0.1	0.1	0.1	-0.3	-0.4	0.4	-0.4	-0.4	0.4	-0.3	-0.3	0.3	-0.4	-0.4
Mn content in liver	0.6	0.7	1.0	-0.4	-0.7	0.7	-0.7	-0.8	0.9	-1.0	-1.0	1.0	-1.0	-0.9
Na content in liver	0.5	0.6	1.0	0.2	0.5	-0.6	0.6	0.7	-0.8	0.9	0.9	-0.8	1.0	0.9
Rb content in liver	1.0	1.3	1.9	-0.7	-1.0	1.1	-1.1	-1.2	1.2	-1.1	-1.1	1.0	-1.3	-1.4
Se content in liver	0.0	0.0	0.1	0.1	0.1	-0.1	0.1	0.2	-0.2	0.3	0.3	-0.1	0.2	0.2
Sr content in liver	0.4	0.4	0.9	-0.1	-0.3	0.4	-0.5	-0.5	0.7	-0.7	-0.7	0.6	-0.8	-0.9
Zn content in liver	0.1	0.1	0.3	-0.1	-0.1	0.2	-0.2	-0.4	0.3	-0.4	-0.4	0.4	-0.4	-0.5
Bone: minimum diameter	0.9	1.6	2.3	-0.8	-1.2	1.2	-1.2	-1.2	1.3	-1.5	-1.5	1.3	-1.4	-1.3
Time in familiar zone, hab. session 1	0.0	0.0	0.0	0.0	0.0	-0.0	-0.0	0.1	-0.1	0.2	0.2	-0.2	0.1	0.2
Time in novel zone, hab. session 1	0.3	0.3	0.7	0.8	0.8	-0.7	0.7	0.5	-0.6	0.3	0.3	-0.3	0.4	0.3
Total zone transitions, hab. session 1	0.1	0.2	0.8	0.9	0.5	-0.4	0.5	0.4	-0.2	0.2	0.2	-0.2	0.0	0.0
Total locomotion distance, hab. session 1	0.5	0.8	1.5	-0.2	-0.6	0.7	-0.7	-0.7	1.0	-0.8	-0.8	1.1	-1.2	-1.2
Locomotion velocity, hab. session 1	1.0	1.4	2.0	-0.7	-1.0	1.1	-1.1	-1.1	1.3	-1.1	-1.1	1.3	-1.4	-1.4
Time in familiar zone, hab. session 2	0.2	0.2	0.6	-0.3	-0.2	0.1	-0.1	0.1	-0.3	0.4	0.4	-0.5	0.5	0.8
Time in novel zone, hab. session 2	0.2	0.2	0.5	0.7	0.6	-0.6	0.6	0.4	-0.3	0.3	0.3	-0.1	0.1	-0.0
Total zone transitions, hab. session 2	0.5	0.6	1.2	0.4	0.7	-0.7	0.7	0.7	-1.0	0.7	0.7	-0.7	1.0	1.1
Total locomotion distance, hab. session 2	0.4	0.5	0.9	-0.6	-0.6	0.6	-0.6	-0.8	0.5	-0.7	-0.7	1.0	-0.6	-0.7
Locomotion velocity, hab. session 2	0.5	0.7	1.3	-0.8	-0.8	0.8	-0.8	-0.9	0.6	-1.0	-1.0	1.1	-0.8	-0.8
Novel to familiar place preference ratio	0.5	0.5	0.8	0.6	0.9	-0.9	0.9	0.7	-0.8	0.6	0.6	-0.7	0.8	0.7
Novelty place preference	0.4	0.4	0.7	0.7	0.8	-0.8	0.8	0.6	-0.6	0.5	0.5	-0.5	0.5	0.4
Time in novel zone, NPP test	0.2	0.2	0.3	0.3	0.5	-0.5	0.5	0.4	-0.5	0.3	0.3	-0.3	0.4	0.4
Total zone transitions, NPP test	0.2	0.3	0.8	-0.9	-0.7	0.7	-0.7	-0.7	0.3	-0.6	-0.6	0.5	-0.3	0.0
Total locomotion distance, NPP test	0.4	0.5	0.6	-0.8	-0.8	0.8	-0.8	-0.8	0.6	-0.7	-0.7	0.8	-0.7	-0.5
Locomotion velocity, NPP test	0.3	0.5	0.7	-0.6	-0.7	0.7	-0.7	-0.8	0.6	-0.7	-0.7	0.8	-0.7	-0.6
Intraocular pressure	0.0	0.0	0.1	0.2	0.3	-0.3	0.3	-0.1	-0.2	-0.1	-0.1	-0.3	-0.1	-0.1
Delta distance traveled before/after self-admin	0.7	0.8	1.3	-0.8	-0.8	0.8	-0.8	-0.9	0.6	-1.0	-1.0	1.2	-0.8	-0.7
Delta ambulatory time before/after self-admin	2.1	2.3	3.5	-1.3	-1.4	1.4	-1.4	-1.6	1.3	-1.6	-1.6	1.9	-1.5	-1.4
Parametrial fat weight	0.1	0.1	0.2	0.5	0.3	-0.3	0.3	0.3	-0.3	0.4	0.4	-0.3	0.2	0.1
Pavlov. Cond. lever latency	0.7	0.9	1.7	-0.3	-0.6	0.7	-0.7	-0.8	1.0	-1.1	-1.1	1.0	-1.2	-1.3
Pavlov. Cond. magazine entry latency	0.4	0.6	1.0	0.4	0.5	-0.6	0.6	0.7	-0.8	0.9	0.9	-0.8	0.9	1.0
Pavlov. Cond. change in total contacts	0.2	0.2	0.6	0.0	0.3	-0.3	0.3	0.4	-0.6	0.5	0.5	-0.4	0.7	0.8
Pavlov. Cond. index score	0.9	1.1	2.1	0.4	0.7	-0.8	0.8	0.9	-1.2	1.2	1.2	-1.0	1.3	1.5
Pavlov. Cond. latency score	0.7	0.8	1.6	0.3	0.6	-0.7	0.7	0.8	-1.0	1.1	1.1	-0.9	1.2	1.3
Pavlov. Cond. lever contacts	1.3	1.5	2.1	0.7	1.0	-1.1	1.1	1.1	-1.3	1.4	1.4	-1.2	1.4	1.5
Pavlov. Cond. magazine entry number	0.6	0.7	1.8	-0.3	-0.5	0.6	-0.6	-0.7	1.0	-1.0	-1.0	0.8	-1.1	-1.3
Pavlov. Cond. intertrial magazine entries	6.5	7.9	11.5	-3.4	-3.1	3.0	-3.0	-3.0	2.7	-2.7	-2.7	2.5	-2.4	-2.2
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	1.8	0.3	0.7	-0.8	0.8	0.8	-1.1	1.1	1.1	-0.9	1.2	1.3
Pavlov. Cond. response bias	0.8	1.0	2.4	0.3	0.6	-0.7	0.7	0.8	-1.1	1.1	1.1	-1.0	1.3	1.5
Pavlov. Cond. lever latency	1.4	1.8	3.7	-1.9	-1.6	1.5	-1.5	-1.5	1.2	-1.2	-1.2	1.1	-0.9	-0.8
Pavlov. Cond. magazine entry latency	3.2	3.7	4.2	2.0	2.0	-2.0	2.0	2.0	-2.0	1.7	1.7	-1.8	1.8	1.8
Pavlov. Cond. change in total contacts	3.9	5.4	8.3	2.9	2.6	-2.5	2.5	2.5	-2.1	2.1	2.1	-2.2	1.9	1.7
Pavlov. Cond. index score	3.1	3.9	5.6	2.4	2.2	-2.1	2.1	2.1	-1.9	1.8	1.8	-1.8	1.7	1.6
Pavlov. Cond. latency score	3.2	4.0	5.1	2.3	2.2	-2.1	2.1	2.1	-1.9	1.9	1.9	-1.9	1.8	1.8
Pavlov. Cond. lever contacts	1.9	2.6	4.1	2.0	1.9	-1.8	1.8	1.8	-1.5	1.5	1.5	-1.4	1.3	1.2
Pavlov. Cond. magazine entry number	2.4	2.9	3.5	-1.9	-1.9	1.8	-1.8	-1.8	1.8	-1.5	-1.5	1.6	-1.6	-1.6
Pavlov. Cond. intertrial magazine entries	5.1	6.6	6.9	-2.6	-2.6	2.6	-2.6	-2.6	2.6	-2.6	-2.6	2.6	-2.5	-2.5
Pavlov. Cond. lever-magazine prob. diff.	3.7	4.7	6.6	2.6	2.4	-2.3	2.3	2.3	-2.1	2.0	2.0	-2.1	1.8	1.8
Pavlov. Cond. response bias	2.0	2.8	4.4	2.1	1.9	-1.8	1.9	1.8	-1.7	1.4	1.4	-1.4	1.4	1.3
Time in closed arm before self-admin	4.8	5.4	7.7	2.8	2.7	-2.6	2.6	2.6	-2.1	2.2	2.2	-2.3	1.8	1.5
Time in closed arm after self-admin	1.9	1.9	5.6	2.4	1.9	-1.7	1.7	1.3	-1.0	1.0	1.0	-1.0	0.6	0.3
Time in open arm before self-admin	6.2	6.8	7.5	-2.6	-2.7	2.7	-2.7	-2.7	2.7	-2.5	-2.5	2.6	-2.5	-2.3
Time in open arm after self-admin	4.8	5.2	9.5	-3.1	-2.8	2.7	-2.7	-2.4	2.1	-2.0	-2.0	1.9	-1.6	-1.3
Bone: periosteal estimation	0.1	0.2	0.5	0.6	0.2	-0.1	0.1	-0.0	0.2	-0.5	-0.5	0.3	-0.5	-0.7
Bone: periosteal perimeter	0.0	0.0	0.1	0.2	0.1	-0.1	0.1	0.1	-0.2	-0.3	-0.3	-0.1	0.1	0.0
Bone: post-yield work	1.9	2.6	3.3	-1.6	-1.8	1.8	-1.8	-1.5	1.8	-1.4	-1.4	1.4	-1.6	-1.5
Progressive ratio test 1 active lever presses	0.0	0.0	0.0	-0.1	0.1	-0.1	0.1	-0.1	-0.2	-0.1	-0.1	0.1	-0.0	-0.1
Progressive ratio test 1 breakpoint	0.0	0.0	0.2	0.0	0.3	-0.3	0.3	0.1	-0.4	0.0	0.0	-0.1	0.2	0.2
Progressive ratio test 1 inactive lever presses	3.2	3.5	4.1	-2.0	-1.8	1.8	-1.8	-2.0	1.7	-1.9	-1.9	1.9	-1.8	-1.8
Progressive ratio test 2 active lever presses	0.0	0.0	0.0	0.1	0.1	-0.1	0.1	0.1	-0.1	-0.1	-0.1	0.1	-0.0	-0.0
Progressive ratio test 2 breakpoint	0.0	0.0	0.1	-0.0	-0.1	0.1	-0.1	-0.1	0.1	-0.2	-0.2	0.2	-0.2	-0.2
Progressive ratio test 2 inactive lever presses	0.7	0.8	1.6	-0.5	-0.6	0.6	-0.6	-0.7	0.9	-0.9	-0.9	1.2	-1.1	-1.3
Incentive Sensitization - Responses	0.0	0.0	0.1	0.3	0.1	-0.1	0.1	0.1	-0.0	-0.1	-0.1	0.0	-0.1	-0.2
Incentive Sensitization - Breakpoint	0.0	0.0	0.1	0.2	0.0	0.0	-0.0	-0.0	0.2	-0.2	-0.2	0.2	-0.3	-0.3
Sum of active levers in priming session hrs 5-6	0.8	0.8	1.1	0.6	0.8	-0.8	0.8	0.8	-0.9	0.9	0.9	-1.0	1.1	1.0
Progressive ratio	0.4	0.5	1.5	0.9	0.4	-0.2	0.2	-0.3	0.7	-0.5	-0.5	0.7	-0.9	-1.2
Food seeking constrained by brief footshock	0.4	0.5	1.1	-0.9	-0.5	0.5	-0.5	-0.8	0.7	-0.7	-0.7	0.5	-0.8	-1.0
Seeking ratio, punishment vs. effort	0.2	0.3	1.6	-1.3	-0.6	0.5	-0.5	-0.2	-0.1	0.0	0.0	-0.2	0.1	0.3
Retroperitoneal fat weight	0.2	0.7	1.1	0.2	0.7	-0.7	0.7	0.6	-1.0	0.9	0.9	-1.0	1.0	1.1
Reaction time number correct	3.4	4.9	7.0	-2.6	-2.4	2.4	-2.4	-2.4	2.1	-2.1	-2.1	2.2	-1.9	-1.8
Reaction time mean minus median	0.0	0.0	0.1	-0.1	0.2	-0.2	0.2	0.0	-0.4	0.2	0.2	0.0	0.2	0.2
Reaction time mean minus median AUC	0.0	0.0	0.1	-0.2	0.1	-0.0	0.0	-0.3	-0.2	-0.0	-0.0	0.2	-0.0	0.0
Reaction time num false alarms	1.3	1.7	2.5	-1.6	-1.4	1.3	-1.3	-1.5	1.0	-1.5	-1.5	1.3	-1.0	-0.9
Reaction time num false alarms AUC	1.6	2.2	2.9	-1.6	-1.6	1.5	-1.5	-1.7	1.2	-1.7	-1.7	1.6	-1.2	-1.2
Reaction time trials correct on left	3.4	4.9	7.0	-2.6	-2.4	2.4	-2.4	-2.4	2.1	-2.1	-2.1	2.2	-1.9	-1.8
Reaction time trials on left	3.5	5.1	7.1	-2.7	-2.4	2.4	-2.4	-2.4	2.1	-2.1	-2.1	2.2	-2.0	-1.8
Reaction time mean	0.7	1.0	1.9	1.4	1.3	-1.2	1.2	1.0	-0.9	0.8	0.8	-0.6	0.6	0.4
Reaction time mean AUC	0.3	0.4	1.0	1.0	1.0	-0.9	0.8	0.6	-0.6	0.5	0.5	-0.3	0.3	0.2
Median of all reaction times	0.4	0.6	1.7	1.3	1.1	-0.9	0.9	0.8	-0.5	0.5	0.5	-0.3	0.2	0.0
Reaction time omissions	1.9	2.6	3.7	-1.5	-1.4	1.4	-1.4	-1.9	1.2	-1.9	-1.9	1.8	-1.5	-1.5
Reaction time false alarm rate	0.1	0.2	0.4	-0.3	-0.3	0.3	-0.3	-0.5	0.2	-0.6	-0.6	0.4	-0.3	-0.3
Reaction time premature initiation rate	0.5	0.6	1.1	-0.6	-0.7	0.7	-0.8	-0.6	1.0	-0.7	-0.7	0.8	-0.9	-1.0
Reaction time premature initiations	2.2	3.0	3.5	-1.9	-1.8	1.8	-1.8	-1.7	1.9	-1.5	-1.5	1.7	-1.7	-1.7
Std. dev. reaction times	0.3	0.4	0.9	0.9	1.0	-0.9	0.9	0.5	-0.6	0.5	0.5	-0.2	0.3	0.2
Reaction time trials completed	3.5	5.1	7.1	-2.7	-2.4	2.4	-2.4	-2.4	2.1	-2.1	-2.1	2.2	-2.0	-1.8
Reaction time trials AUC	3.6	5.2	7.2	-2.7	-2.5	2.4	-2.4	-2.4	2.1	-2.1	-2.1	2.3	-2.0	-1.9
Run reversals in cocaine runway, females	1.5	1.4	2.2	1.4	1.5	-1.4	1.4	1.3	-1.1	1.1	1.1	-0.9	1.0	0.8
Run reversals in cocaine runway, males	0.1	0.1	0.4	-0.0	-0.1	0.1	-0.1	-0.1	0.4	-0.2	-0.2	0.1	-0.5	-0.6
Latency to leave start box in cocaine runway	0.3	0.3	0.7	0.8	0.8	-0.8	0.8	0.3	-0.6	0.3	0.3	-0.2	0.5	0.3
Latency to leave start box in cocaine runway, F	0.5	0.6	0.8	0.9	0.8	-0.8	0.8	0.6	-0.8	0.7	0.7	-0.5	0.9	0.7
Latency to leave start box in cocaine runway, M	0.2	0.2	0.5	0.4	0.7	-0.7	0.7	0.2	-0.5	0.3	0.3	-0.4	0.5	0.3
Std. dev. time between licks in bursts	0.0	0.0	0.1	-0.3	-0.3	0.3	-0.3	-0.2	0.1	-0.0	-0.0	0.2	-0.1	0.2
Total sessions with >9 infusions	0.0	0.0	0.1	0.0	0.1	-0.1	0.1	0.1	-0.1	-0.0	-0.0	0.2	0.0	0.0
Short access day 1 total inactive lever presses	0.1	0.1	0.2	-0.1	-0.1	0.2	-0.2	-0.3	0.4	-0.3	-0.3	0.3	-0.4	-0.4
Short access day 10 total inactive lever presses	0.9	1.0	1.4	-0.8	-0.8	0.9	-0.9	-1.1	1.0	-1.1	-1.1	0.9	-1.2	-1.2
Short access day 1 total infusions	0.3	0.3	0.6	-0.2	-0.3	0.4	-0.4	-0.5	0.7	-0.6	-0.6	0.5	-0.7	-0.8
Short access day 10 total infusions	0.2	0.2	0.4	0.6	0.5	-0.5	0.5	0.5	-0.6	0.4	0.4	-0.3	0.4	0.4
Short access total infusions	0.2	0.2	0.6	0.8	0.6	-0.5	0.6	0.4	-0.3	0.2	0.2	-0.2	0.2	0.1
Short access day 1 locomotion	0.3	0.3	0.4	0.6	0.6	-0.6	0.6	0.5	-0.5	0.5	0.5	-0.6	0.4	0.4
Short access day 10 total locomotion	0.4	0.4	0.9	0.3	0.4	-0.5	0.5	0.7	-0.9	0.6	0.6	-0.7	0.9	1.0
Short access total locomotion	0.0	0.0	0.1	0.2	0.1	-0.2	0.2	0.1	-0.2	0.0	0.0	-0.0	0.1	0.1
One hour access (0.3 mA shock)	0.2	0.2	0.7	-0.9	-0.6	0.5	-0.5	-0.4	0.3	-0.3	-0.3	0.3	-0.2	-0.1
Compulsive drug intake	0.1	0.1	0.2	-0.3	-0.4	0.4	-0.4	-0.3	0.2	0.0	0.0	-0.3	0.1	0.3
One hour access (shock baseline)	0.0	0.0	0.1	-0.2	0.3	-0.2	0.2	0.3	-0.2	0.1	0.1	0.0	0.1	0.1
Social response proportion	0.3	0.3	1.2	0.5	0.1	0.1	-0.1	-0.0	0.6	-0.6	-0.6	0.6	-0.9	-1.1
Social responses	0.1	0.1	0.2	0.5	0.4	-0.4	0.4	0.2	-0.1	0.0	0.0	-0.0	-0.1	-0.2
Social time	1.8	2.4	4.7	-0.6	-0.9	1.1	-1.1	-1.4	1.7	-1.8	-1.8	1.7	-2.1	-2.2
Soleus weight	0.5	1.3	4.9	-2.2	-1.6	1.4	-1.4	-1.2	0.5	-0.7	-0.7	0.4	-0.1	0.4
Bone: stiffness	1.2	1.9	2.3	-1.2	-1.5	1.5	-1.5	-1.3	1.5	-1.4	-1.4	1.2	-1.4	-1.4
Tibialis anterior weight	0.4	1.5	3.2	-1.8	-1.5	1.5	-1.5	-1.3	1.0	-1.0	-1.0	0.8	-0.8	-0.6
Time to tail flick, vehicle, before self-admin	1.0	1.0	3.1	-1.8	-1.2	1.1	-1.1	-1.0	0.7	-0.8	-0.8	0.9	-0.5	-0.3
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.7	-0.8	-0.6	0.5	-0.5	-0.4	0.1	-0.3	-0.3	0.2	0.0	0.3
Time to tail flick, test, before self-admin	0.0	0.0	0.1	0.0	0.1	-0.0	0.0	-0.2	0.0	-0.1	-0.1	0.0	-0.2	-0.3
Time to tail flick, test, after self-admin	2.3	2.3	4.3	-2.1	-1.9	1.8	-1.8	-1.3	1.3	-1.4	-1.4	1.5	-1.1	-0.8
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.1	-0.2	-0.2	0.2	-0.2	-0.2	0.0	-0.1	-0.1	0.0	0.0	0.2
Delta time to tail flick, test, before/after SA	2.3	2.0	3.7	-1.9	-1.8	1.7	-1.7	-1.4	1.2	-1.3	-1.3	1.3	-1.0	-0.6
Tibia length	0.1	0.2	0.4	-0.4	-0.4	0.4	-0.4	-0.4	0.3	-0.6	-0.6	0.5	-0.4	-0.5
Ambulatory time before self-admin	1.3	1.4	2.1	1.5	1.2	-1.2	1.2	1.0	-1.0	1.2	1.2	-1.4	1.1	0.8
Ambulatory time after self-admin	0.0	0.0	0.2	0.4	0.2	-0.2	0.2	-0.2	-0.2	-0.0	-0.0	-0.0	-0.0	-0.1
Bone: tissue strength	0.1	0.1	0.3	0.6	0.4	-0.3	0.4	0.3	-0.2	0.0	0.0	-0.0	0.0	-0.1
Total heroin consumption	0.5	0.6	2.3	-1.5	-1.1	0.9	-0.9	-1.0	0.5	-0.4	-0.4	0.3	-0.1	0.0
Bone: trabecular number	0.3	0.5	0.6	-0.7	-0.7	0.7	-0.7	-0.7	0.6	-0.8	-0.8	0.8	-0.5	-0.5
Bone: trabecular spacing	0.1	0.1	0.2	0.2	0.3	-0.3	0.3	0.2	-0.3	0.4	0.4	-0.3	0.3	0.3
Bone: trabecular thickness	0.1	0.1	0.1	-0.2	-0.2	0.2	-0.2	-0.2	0.2	-0.4	-0.4	0.3	-0.2	-0.2
Bone: trabecular tissue density	0.0	0.0	0.0	0.0	0.1	-0.1	0.1	0.1	-0.2	0.1	0.1	-0.2	0.2	0.0
Water consumed over 24 hours	2.4	2.9	3.7	-1.4	-1.6	1.6	-1.6	-1.7	1.7	-1.8	-1.8	1.8	-1.8	-1.9
Number of responses in last shaping day	0.4	0.4	0.7	0.8	0.7	-0.7	0.7	0.7	-0.7	0.5	0.5	-0.6	0.6	0.6