Hub : Genes

Ikzf3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC gene expression Ikzf3 0.12 0.08 1.0e-05 0.11 0.11 0.11 0.11 3.0e-05 3.0e-05 2.0e-05 2.2e-05
2 Liver gene expression Ikzf3 0.07 0.06 4.8e-06 0.06 0.05 0.05 0.05 3.9e-07 5.7e-06 6.1e-06 1.3e-06
3 NAcc isoform ratio XM_008768049.4 0.03 0.02 4.0e-06 0.04 0.03 0.03 0.04 1.3e-06 1.0e-05 1.1e-05 2.8e-06
4 NAcc alternative TSS NM_001107047.1 0.02 0.01 3.4e-04 0.03 0.02 0.03 0.03 6.2e-05 2.0e-04 3.0e-05 9.1e-05
5 NAcc alternative TSS XM_008768049.4 0.02 0.01 4.6e-04 0.02 0.02 0.03 0.02 1.1e-04 2.5e-04 4.7e-05 1.8e-04
6 IC alternative TSS NM_001107047.1 0.06 0.05 6.9e-03 0.03 0.01 0 0.01 2.8e-02 7.6e-02 1.9e-01 7.5e-02
7 IC alternative TSS XM_008768049.4 0.06 0.05 6.0e-03 0.03 0.02 0 0.01 2.5e-02 6.4e-02 2.3e-01 7.5e-02
8 NAcc gene expression Ikzf3 0.25 0.12 1.5e-12 0.08 0.08 0.1 0.09 6.8e-12 8.4e-12 2.8e-14 1.1e-13
9 Adipose gene expression Ikzf3 0.02 0.02 6.8e-03 0.02 0.01 0.01 0.01 3.5e-03 1.9e-02 2.3e-02 8.2e-03
10 PL gene expression Ikzf3 0.08 0.04 2.1e-09 0.07 0.08 0.08 0.07 6.7e-08 3.8e-09 8.1e-09 4.0e-08
11 Brain gene expression Ikzf3 0.11 0.07 2.7e-04 0.01 0.05 0.04 0.04 3.1e-02 4.0e-05 3.3e-04 1.5e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density2.44.26.31.92.5-2.41.9-1.82.0-2.01.72.12.11.8
Area under the delay curve0.40.50.70.70.7-0.80.8-0.80.6-0.60.70.80.70.0
BMI with tail2.06.911.7-3.0-2.12.8-3.13.2-2.62.6-3.4-2.5-1.8-0.3
BMI without tail0.82.66.0-1.8-0.81.6-2.02.1-1.51.5-2.4-1.0-1.20.2
Body weight5.724.831.7-5.6-4.75.4-5.55.6-5.25.2-5.6-4.7-4.3-1.2
Weight adjusted by age0.50.71.7-1.0-1.00.7-0.60.5-1.31.3-0.3-0.80.00.7
Bone surface0.20.41.60.20.7-0.60.4-0.40.4-0.40.30.60.71.3
Bone volume0.50.83.30.50.9-0.90.6-0.60.7-0.70.70.71.21.8
Breakpoint value in progressive ratio session0.40.51.3-0.8-0.60.5-0.50.5-1.11.1-0.4-0.5-0.70.4
Number of licking bursts0.20.31.20.40.2-0.40.4-0.40.3-0.30.60.10.91.1
Context. condit. distance diff. score1.61.94.8-1.2-1.41.3-1.11.1-1.31.3-0.8-1.4-1.6-2.2
Locomotion velocity, session 10.30.30.7-0.6-0.40.5-0.20.1-0.80.80.1-0.8-0.50.3
Locomotion distance, session 11.51.83.0-1.7-0.81.3-1.51.5-1.71.7-1.5-1.0-1.20.2
Locomotion velocity, session 20.10.10.3-0.4-0.00.2-0.30.3-0.30.3-0.3-0.2-0.6-0.3
Locomotion distance, session 20.20.31.4-0.50.40.0-0.30.4-0.30.3-0.70.30.01.2
Locomotion velocity, session 30.10.10.4-0.10.7-0.2-0.30.40.1-0.1-0.40.5-0.3-0.4
Locomotion distance, session 30.30.40.8-0.7-0.20.5-0.70.7-0.70.7-0.9-0.4-0.5-0.2
Stereotopy head waving bouts, day 32.42.94.51.91.9-1.91.7-1.61.8-1.81.42.11.50.4
Stereotopy head waving duration, day 30.30.40.90.70.6-0.70.6-0.50.7-0.70.40.90.50.1
Locomotion velocity, session 70.80.81.6-1.0-1.31.0-0.80.7-1.21.2-0.7-1.0-0.70.0
Locomotion distance, session 70.30.41.3-0.6-1.10.4-0.30.2-0.90.9-0.1-1.0-0.5-0.2
Stereotopy head waving bouts, day 70.70.81.20.91.0-1.00.8-0.70.8-0.80.51.11.10.5
Stereotopy head waving duration, day 70.20.20.60.40.7-0.50.3-0.20.5-0.5-0.10.80.60.2
Locomotion velocity, session 86.78.19.5-3.0-2.93.1-2.82.7-3.13.1-2.3-3.1-3.0-2.1
Locomotion distance, session 81.21.72.1-1.5-1.31.4-1.41.4-1.41.4-1.4-1.2-1.3-0.6
Degree of sensitization distance0.70.72.1-0.7-1.40.8-0.50.4-0.80.8-0.2-1.3-0.8-0.7
Degree of sensitization stereotypy0.70.71.50.90.9-0.90.9-0.80.8-0.80.60.91.20.6
Conditioned locomotion0.10.20.20.50.2-0.50.5-0.50.4-0.40.40.40.2-0.2
Cocaine response after cond. corrected1.21.53.01.01.3-1.41.3-1.30.6-0.61.30.81.71.5
Cocaine response after cond. not corrected1.51.83.61.11.2-1.51.5-1.60.6-0.61.70.61.91.6
Cocaine response before conditioning0.10.10.40.2-0.1-0.30.5-0.5-0.10.10.6-0.10.2-0.2
Saline control response0.30.41.1-0.6-0.90.3-0.20.1-0.80.80.1-1.0-0.2-0.1
Bone: connectivity density3.65.68.52.22.9-2.82.3-2.22.4-2.41.92.72.31.7
Bone: cortical apparent density4.66.28.92.82.6-2.72.9-2.92.4-2.43.02.31.90.3
Bone: cortical area0.10.20.70.40.2-0.30.5-0.60.2-0.20.80.20.40.2
Bone: cortical porosity0.70.71.30.80.3-0.80.9-1.00.6-0.61.10.41.11.1
Bone: cortical porosity0.40.51.20.60.0-0.60.7-0.80.2-0.21.10.11.01.1
Bone: cortical thickness0.81.32.51.21.3-1.31.3-1.40.9-0.91.60.91.0-0.0
Bone: cortical thickness4.14.85.82.42.2-2.32.3-2.42.3-2.32.42.31.90.9
Bone: cortical tissue density4.66.39.02.82.7-2.72.9-3.02.4-2.43.02.31.90.4
Condit. Reinf. active minus inactive responses1.01.12.61.01.6-1.21.1-1.10.9-0.91.11.20.60.1
Condit. Reinf. active-inactive response ratio0.91.02.11.01.4-1.31.1-1.00.8-0.80.91.10.4-0.4
Condit. Reinf. active responses0.91.22.11.11.5-1.21.2-1.20.9-0.91.31.10.70.2
Condit. Reinf. inactive responses0.20.20.50.30.2-0.20.3-0.40.3-0.30.70.30.70.6
Incentive salience index mean2.22.74.11.72.0-1.71.8-1.91.6-1.61.91.61.20.7
Condit. Reinf. lever presses1.92.64.51.71.7-1.41.8-2.01.5-1.52.11.31.41.2
Condit. Reinf. active minus inactive responses0.70.91.40.90.7-0.80.9-0.91.0-1.01.00.91.11.2
Condit. Reinf. active-inactive response ratio0.80.91.80.90.8-0.80.7-0.71.1-1.10.61.01.21.3
Condit. Reinf. active responses1.31.93.01.31.1-1.21.3-1.31.4-1.41.41.41.51.7
Condit. Reinf. inactive responses1.72.23.21.51.2-1.51.7-1.71.3-1.31.81.41.51.5
Condit. Reinf. lever presses0.00.10.30.20.3-0.20.3-0.20.2-0.20.10.50.1-0.0
Condit. Reinf. lever reinforcers received1.42.02.41.41.3-1.31.4-1.51.4-1.41.51.51.41.5
Conditioned reinforcement - actives0.10.20.60.2-0.5-0.00.2-0.4-0.40.40.8-0.70.2-0.2
Conditioned reinforcement - inactives0.20.20.40.60.4-0.50.5-0.50.6-0.60.60.50.10.1
Conditioned locomotion0.40.51.10.70.6-0.80.8-0.90.1-0.11.10.31.00.5
Patch foraging indifference point 0 sec1.42.73.91.91.7-1.91.8-1.81.6-1.61.42.01.10.2
Patch foraging indifference point AUC0.00.00.10.10.1-0.10.2-0.2-0.20.20.30.20.10.1
Delay disc. indifference point, 0s delay1.82.02.91.51.1-1.71.6-1.61.4-1.41.41.61.40.7
Delay disc. indifference point, 16s delay0.40.40.80.80.4-0.60.7-0.70.6-0.60.80.20.1-0.9
Delay disc. indifference point, 2s delay1.31.52.51.11.0-1.41.5-1.50.7-0.71.51.11.61.2
Delay disc. indifference point, 24s delay0.10.20.8-0.0-0.10.4-0.30.3-0.10.1-0.5-0.4-0.4-0.9
Delay disc. indifference point, 4s delay0.90.91.70.90.6-1.11.2-1.20.8-0.81.30.71.00.7
Delay disc. indifference point, 8s delay0.10.20.30.50.5-0.40.3-0.20.5-0.50.00.50.4-0.1
Indifference point function ln k0.10.21.2-0.10.10.1-0.20.2-0.00.0-0.60.0-0.5-1.1
Indifference point function log k0.10.21.2-0.10.10.1-0.20.2-0.00.0-0.60.0-0.5-1.1
Patch foraging total patch changes 0 sec1.01.92.91.61.5-1.61.6-1.51.3-1.31.11.70.90.1
Patch foraging total patch changes 12 sec4.35.57.32.52.2-2.52.4-2.32.3-2.32.12.72.51.9
Patch foraging total patch changes 18 sec0.20.30.90.70.5-0.60.6-0.60.5-0.50.60.90.40.1
Patch foraging total patch changes 24 sec0.50.81.30.91.0-1.11.1-1.10.5-0.50.90.81.10.4
Patch foraging total patch changes 6 sec1.92.94.71.91.8-1.81.8-1.81.6-1.61.62.21.30.8
Patch foraging time to switch 0 sec0.00.10.30.20.3-0.30.2-0.20.2-0.20.10.50.30.5
Patch foraging water rate 0 sec0.10.10.30.40.5-0.40.3-0.30.5-0.50.20.40.1-0.0
Patch foraging water rate 12 sec0.20.51.1-0.6-1.00.8-0.60.5-0.50.5-0.4-1.0-0.7-0.5
Patch foraging water rate 18 sec0.30.50.90.60.9-0.80.5-0.50.8-0.80.40.60.90.9
Patch foraging water rate 24 sec0.60.91.70.91.0-0.90.7-0.71.3-1.30.81.00.70.6
Patch foraging water rate 6 sec1.52.22.91.51.7-1.71.5-1.51.7-1.71.51.11.31.0
Seeking ratio, delayed vs. immediate footshock0.60.71.6-0.3-0.8-0.30.7-0.8-0.70.71.2-1.3-0.8-0.9
Distance traveled before self-admin0.20.31.10.4-0.70.00.4-0.60.5-0.50.8-0.30.21.1
Distance traveled after self-admin0.20.30.6-0.4-0.50.8-0.70.7-0.10.1-0.7-0.3-0.70.1
Extensor digitorum longus weight8.834.642.7-6.2-6.26.2-5.85.5-6.46.4-4.8-6.5-6.0-4.2
Bone: elastic displacement0.00.00.1-0.00.2-0.30.1-0.0-0.20.2-0.10.10.0-0.2
Bone: elastic work0.20.20.50.30.5-0.60.4-0.40.2-0.20.40.40.40.7
Bone: endosteal estimation1.43.25.0-1.9-2.22.0-1.91.9-1.71.7-2.0-1.8-1.30.2
Bone: endosteal perimeter1.02.24.0-1.5-2.01.8-1.71.6-1.21.2-1.5-1.4-1.4-0.1
Epididymis fat weight0.10.40.9-0.6-0.90.7-0.50.4-0.90.9-0.0-0.9-0.30.5
Delta time in closed arm before/after self-admin3.83.55.5-2.3-1.21.9-2.12.1-2.32.3-2.2-1.0-1.7-0.9
Delta time in open arm before/after self-admin0.10.10.70.1-0.20.00.1-0.10.3-0.30.3-0.8-0.1-0.2
Diff in mean of infusions in LGA sessions0.20.20.5-0.50.10.3-0.40.5-0.70.7-0.50.1-0.20.5
Delay discount exponential model param0.20.30.4-0.5-0.60.6-0.60.6-0.40.4-0.5-0.6-0.40.1
Extinction: sum of active levers before priming1.21.31.9-1.2-1.01.2-1.41.4-1.31.3-1.3-1.0-0.9-0.6
Active lever presses in extinction session 61.01.04.90.70.8-0.90.8-0.70.5-0.50.50.91.32.2
Bone: final force0.81.32.21.10.8-1.11.2-1.30.9-0.91.20.81.51.5
Bone: final moment0.61.01.91.00.7-0.91.0-1.10.8-0.81.10.71.31.4
Food consumed during 24 hour testing period0.71.02.0-1.0-1.41.0-1.11.1-0.80.8-1.0-1.0-0.9-0.4
Glucose0.40.72.60.5-0.1-0.91.1-1.2-0.10.11.6-0.10.80.6
Heart weight2.84.36.5-2.3-2.12.1-1.91.8-2.62.6-1.6-2.4-2.0-1.0
Delay discount hyperbolic model param0.20.20.4-0.5-0.50.6-0.60.6-0.30.3-0.5-0.6-0.50.0
Intermittent access intake day 1-15 change0.10.10.3-0.20.4-0.0-0.10.30.4-0.4-0.40.5-0.10.4
Intermittent access intake escalation0.10.10.3-0.20.30.0-0.20.30.4-0.4-0.40.5-0.20.3
Intermittent access intake escalation 20.30.31.1-0.7-0.10.6-0.80.90.0-0.0-1.1-0.1-0.50.1
Intermitt. access day 1 inactive lever presses0.72.64.31.52.1-1.61.4-1.32.0-2.01.02.01.01.0
Intermitt. access day 15 inactive lever presses1.12.34.41.72.1-1.41.2-1.12.0-2.00.82.00.90.2
Intermitt. access escalation Index2.13.05.1-1.8-1.62.0-2.22.2-1.41.4-2.3-1.4-1.2-1.0
Intermittent access day 1 total infusions0.00.10.30.2-0.40.10.1-0.3-0.20.20.5-0.3-0.1-0.1
Intermittent access day 15 total infusions0.00.00.2-0.1-0.10.2-0.10.10.0-0.00.00.1-0.4-0.2
Intermittent access terminal intake (last 3 days)0.10.10.30.40.3-0.10.1-0.00.6-0.60.10.4-0.10.0
Intermittent access total infusions0.00.00.20.1-0.40.2-0.10.0-0.00.00.2-0.2-0.4-0.2
Intermittent access day 1 locomotion0.10.20.60.3-0.2-0.20.5-0.6-0.30.30.8-0.10.1-0.1
Intermittent access day 15 total locomotion0.20.40.80.50.5-0.80.8-0.90.0-0.00.90.50.80.6
Intermittent access total locomotion0.60.71.31.00.7-1.01.1-1.10.5-0.51.10.80.80.3
Intermittent access standard deviation0.81.63.01.21.5-1.11.0-0.91.7-1.70.81.60.70.9
Left kidney weight0.41.93.5-1.5-1.31.5-1.91.9-0.80.8-1.7-0.6-1.7-0.7
Right kidney weight0.10.31.0-0.20.20.1-0.50.60.5-0.5-0.70.50.11.0
Cocaine induced anxiety2.63.88.0-1.9-1.32.2-2.62.7-1.51.5-2.8-1.2-1.7-0.7
Post-drug Anxiety1.11.23.1-1.1-0.61.1-1.51.6-0.60.6-1.8-0.5-1.0-0.7
Baseline Anxiety1.51.74.11.20.6-1.51.8-1.90.8-0.82.00.71.40.4
Tail length0.51.83.2-1.4-1.41.2-1.21.1-1.61.6-1.1-1.2-1.8-0.8
Length with tail2.310.212.3-3.5-3.33.5-3.43.3-3.43.4-3.2-2.9-3.3-1.0
Length without tail2.88.911.5-3.3-3.33.3-3.02.9-3.43.4-2.8-3.2-2.6-1.0
Times rat made contact with spout1.01.11.61.11.1-1.11.0-0.91.2-1.20.90.91.31.0
Lifetime Intake0.00.00.20.2-0.1-0.10.2-0.30.1-0.10.50.0-0.3-0.1
Liver weight, left0.20.30.7-0.7-0.30.4-0.40.3-0.80.8-0.2-0.6-0.20.3
Liver weight, right0.61.02.01.01.3-1.30.9-0.90.9-0.90.71.40.60.2
Locomotor activity0.50.82.10.80.7-0.70.8-0.90.8-0.80.90.31.31.5
Locomotor testing distance1.62.93.91.91.6-1.71.7-1.62.0-2.01.51.61.91.2
Locomotor testing rearing4.48.911.73.43.3-3.23.1-3.03.4-3.42.53.22.41.0
Locomotion in novel chamber5.16.512.72.61.8-3.13.2-3.41.7-1.73.61.52.51.8
Locomotion in novel chamber post-restriction0.40.72.40.60.9-0.70.5-0.40.8-0.80.10.81.11.6
Fecal boli incidents, locomotor time 10.10.20.7-0.4-0.10.2-0.10.0-0.80.8-0.0-0.5-0.20.0
Change in fecal boli incidents, locomotor task0.10.10.30.2-0.1-0.50.5-0.50.1-0.10.6-0.10.3-0.0
Time >=10cm from walls, locomotor time 10.20.30.50.30.1-0.60.7-0.7-0.40.40.70.30.1-0.7
Bouts of movement, locomotor time 10.70.82.8-0.8-0.21.2-1.11.2-0.30.3-1.70.1-0.6-0.2
Total resting periods, locomotor time 11.01.13.1-1.1-0.51.5-1.31.4-0.70.7-1.8-0.3-0.7-0.2
Rest time, locomotor task time 10.20.20.80.10.60.2-0.30.30.3-0.3-0.70.90.20.5
Distance moved, locomotor task time 10.20.31.3-0.1-0.5-0.50.5-0.6-0.70.71.1-0.50.1-0.0
Vertical activity count, locomotor time 10.41.02.8-0.8-1.10.20.0-0.2-1.71.70.7-1.6-0.4-0.1
Time >=10cm from walls, locomotor time 20.91.34.40.9-0.6-1.21.5-1.70.0-0.02.1-0.31.10.6
Bouts of movement, locomotor time 20.20.30.70.70.6-0.30.4-0.40.9-0.90.20.70.1-0.4
Total resting periods, locomotor time 20.10.20.30.40.5-0.10.2-0.20.6-0.6-0.10.5-0.2-0.5
Rest time, locomotor task time 20.70.91.7-1.0-0.50.9-0.90.9-1.31.3-1.2-0.6-0.9-0.4
Distance moved, locomotor task time 20.20.20.6-0.2-0.3-0.20.2-0.3-0.70.70.7-0.30.10.2
Vertical activity count, locomotor time 20.50.62.0-0.8-0.60.3-0.30.2-1.41.40.1-1.1-0.5-0.4
Light reinforcement 11.74.36.72.12.5-2.11.9-1.82.3-2.31.42.61.81.4
Light reinforcement 21.01.52.71.11.6-1.21.2-1.21.0-1.01.01.31.31.5
Bone: marrow area1.43.04.7-1.8-2.22.0-1.91.9-1.61.6-1.9-1.7-1.30.1
Bone: maximum diameter0.00.10.40.2-0.20.20.0-0.10.3-0.30.40.20.30.7
Bone: maximum force0.00.00.3-0.1-0.10.10.0-0.1-0.10.10.1-0.20.20.6
Bone: maximum moment0.00.10.2-0.2-0.20.2-0.10.1-0.20.2-0.1-0.40.10.4
Mean time between licks in bursts0.71.82.9-1.4-1.31.7-1.61.5-1.21.2-1.3-1.4-1.2-0.5
Mean num. licks in bursts0.10.20.40.40.6-0.50.3-0.30.5-0.50.10.60.0-0.3
Cd content in liver1.41.62.4-1.3-1.01.4-1.51.5-1.21.2-1.5-1.3-1.1-0.5
Co content in liver2.02.33.1-1.6-1.41.5-1.61.6-1.41.4-1.5-1.5-1.8-1.4
Cu content in liver0.10.10.30.10.3-0.20.2-0.20.0-0.00.20.4-0.5-0.4
Fe content in liver1.11.42.0-1.2-1.41.3-1.21.2-1.31.3-1.0-1.1-1.0-0.0
K content in liver0.60.60.90.90.6-0.80.8-0.81.0-1.00.70.80.40.2
Mg content in liver0.50.50.80.90.6-0.70.8-0.70.8-0.80.50.7-0.0-0.9
Mn content in liver0.91.01.51.10.9-1.21.2-1.21.0-1.01.11.00.2-0.3
Na content in liver0.50.52.70.50.3-0.40.5-0.60.5-0.50.60.51.11.7
Rb content in liver2.12.43.51.81.7-1.91.8-1.71.5-1.51.61.61.10.4
Se content in liver6.17.29.23.02.7-2.82.8-2.83.0-3.02.62.82.21.4
Sr content in liver0.60.51.4-0.5-0.60.6-0.50.5-0.50.5-0.5-0.7-1.1-1.2
Zn content in liver3.43.85.62.02.1-2.01.9-1.82.2-2.21.72.41.51.1
Bone: minimum diameter0.30.51.4-0.6-1.20.8-0.60.5-0.80.8-0.4-0.9-0.70.0
Time in familiar zone, hab. session 10.80.82.80.60.5-0.80.7-0.90.5-0.51.30.21.11.7
Time in novel zone, hab. session 10.40.41.20.51.0-0.60.6-0.40.3-0.3-0.10.70.0-1.1
Total zone transitions, hab. session 11.62.23.0-1.7-1.31.5-1.51.4-1.71.7-1.1-1.7-1.6-0.9
Total locomotion distance, hab. session 10.10.10.1-0.3-0.10.2-0.30.3-0.30.3-0.3-0.1-0.3-0.4
Locomotion velocity, hab. session 10.60.81.1-1.0-0.91.0-1.11.1-0.80.8-1.0-0.8-0.9-0.5
Time in familiar zone, hab. session 20.60.71.30.70.9-0.80.8-0.70.7-0.70.80.61.01.1
Time in novel zone, hab. session 20.10.10.20.20.4-0.30.3-0.20.2-0.20.10.40.0-0.3
Total zone transitions, hab. session 20.60.82.0-1.1-0.60.7-0.60.5-1.41.4-0.5-1.0-0.8-0.4
Total locomotion distance, hab. session 20.30.30.7-0.8-0.20.6-0.60.6-0.80.8-0.8-0.2-0.20.3
Locomotion velocity, hab. session 20.50.61.0-1.0-0.70.9-0.80.8-1.01.0-0.9-0.6-0.50.1
Novel to familiar place preference ratio1.82.02.6-1.2-1.61.6-1.51.5-1.01.0-1.4-1.3-1.5-1.5
Novelty place preference1.81.93.0-1.1-1.61.5-1.51.4-0.90.9-1.3-1.4-1.5-1.7
Time in novel zone, NPP test1.01.12.1-0.8-1.21.1-1.11.1-0.70.7-1.0-1.1-1.0-1.4
Total zone transitions, NPP test0.20.40.9-0.7-0.30.5-0.30.1-1.01.00.1-0.8-0.20.7
Total locomotion distance, NPP test0.10.10.8-0.20.4-0.10.0-0.0-0.20.2-0.10.20.40.9
Locomotion velocity, NPP test0.20.20.4-0.6-0.20.6-0.60.6-0.40.4-0.6-0.1-0.30.3
Intraocular pressure2.33.44.7-2.0-2.02.2-2.12.0-1.61.6-1.9-1.5-1.7-1.3
Delta distance traveled before/after self-admin1.31.42.2-1.2-0.41.0-1.31.4-1.31.3-1.5-0.8-1.2-1.2
Delta ambulatory time before/after self-admin1.21.54.0-1.3-0.11.1-1.51.7-1.21.2-2.0-0.4-0.9-0.9
Parametrial fat weight0.51.23.20.91.2-0.90.7-0.71.2-1.20.51.11.41.8
Pavlov. Cond. lever latency3.13.95.2-1.9-2.21.8-1.81.8-1.91.9-1.8-2.0-2.3-2.2
Pavlov. Cond. magazine entry latency9.812.614.53.73.6-3.43.4-3.43.7-3.73.53.63.83.0
Pavlov. Cond. change in total contacts8.99.411.63.43.4-3.03.1-3.13.4-3.43.03.32.81.4
Pavlov. Cond. index score9.111.513.63.53.5-3.23.3-3.33.4-3.43.33.43.73.0
Pavlov. Cond. latency score7.29.111.43.13.2-2.82.9-2.93.0-3.02.93.13.42.8
Pavlov. Cond. lever contacts3.94.76.12.12.2-1.92.0-2.02.2-2.22.12.22.52.4
Pavlov. Cond. magazine entry number12.615.918.6-4.3-4.24.0-4.03.9-4.24.2-3.8-4.1-4.1-2.7
Pavlov. Cond. intertrial magazine entries1.31.62.5-1.3-1.20.9-1.00.9-1.61.6-1.1-1.3-1.5-1.4
Pavlov. Cond. lever-magazine prob. diff.10.813.315.23.83.8-3.53.6-3.63.7-3.73.63.73.93.1
Pavlov. Cond. response bias10.613.114.93.93.8-3.53.6-3.63.8-3.83.63.73.72.7
Pavlov. Cond. lever latency0.40.51.2-0.6-0.60.4-0.50.4-0.80.8-0.5-1.1-0.9-0.8
Pavlov. Cond. magazine entry latency0.10.10.3-0.4-0.50.4-0.20.1-0.50.50.2-0.2-0.00.2
Pavlov. Cond. change in total contacts0.50.81.51.00.7-0.81.0-1.00.9-0.91.21.10.70.3
Pavlov. Cond. index score0.20.20.60.30.3-0.30.3-0.30.4-0.40.50.80.60.7
Pavlov. Cond. latency score0.10.10.30.20.1-0.20.2-0.30.3-0.30.50.60.50.6
Pavlov. Cond. lever contacts0.50.71.30.70.7-0.60.7-0.60.9-0.90.61.21.01.0
Pavlov. Cond. magazine entry number0.10.20.6-0.2-0.40.3-0.30.4-0.10.1-0.7-0.7-0.4-0.4
Pavlov. Cond. intertrial magazine entries2.13.24.3-1.7-1.71.8-1.81.8-1.51.5-2.0-1.7-2.0-2.1
Pavlov. Cond. lever-magazine prob. diff.0.10.10.50.20.2-0.20.2-0.20.3-0.30.40.70.40.5
Pavlov. Cond. response bias0.91.32.11.01.0-0.91.0-1.01.1-1.11.11.41.31.3
Time in closed arm before self-admin2.22.95.82.02.2-1.51.4-1.32.4-2.41.01.90.9-0.1
Time in closed arm after self-admin0.30.41.8-0.20.20.4-0.50.60.1-0.1-0.60.3-1.0-1.3
Time in open arm before self-admin2.12.35.0-1.7-2.21.3-1.00.9-2.22.2-0.7-1.6-1.2-0.2
Time in open arm after self-admin0.30.31.6-0.5-1.00.4-0.20.1-0.50.5-0.0-1.3-0.4-0.0
Bone: periosteal estimation0.20.30.9-0.5-0.90.8-0.60.5-0.50.5-0.5-0.6-0.20.5
Bone: periosteal perimeter0.40.71.6-0.9-1.21.2-1.00.8-0.80.8-0.5-0.8-0.60.5
Bone: post-yield work1.01.42.2-1.2-1.01.4-1.51.4-1.01.0-1.2-1.1-1.2-0.9
Progressive ratio test 1 active lever presses0.00.00.20.4-0.1-0.00.1-0.20.0-0.00.2-0.00.1-0.2
Progressive ratio test 1 breakpoint0.00.00.10.3-0.10.1-0.0-0.0-0.00.00.0-0.00.0-0.3
Progressive ratio test 1 inactive lever presses0.20.20.70.60.7-0.30.2-0.20.6-0.60.10.8-0.0-0.1
Progressive ratio test 2 active lever presses0.70.82.61.10.2-0.81.1-1.30.7-0.71.60.10.70.6
Progressive ratio test 2 breakpoint0.81.02.91.10.2-0.91.2-1.40.7-0.71.70.20.80.7
Progressive ratio test 2 inactive lever presses0.10.10.50.50.1-0.30.4-0.50.3-0.30.70.20.10.3
Incentive Sensitization - Responses1.52.05.21.50.5-1.51.8-1.91.1-1.12.30.51.21.3
Incentive Sensitization - Breakpoint1.51.94.91.40.5-1.41.7-1.81.1-1.12.20.41.21.3
Sum of active levers in priming session hrs 5-60.20.20.30.30.4-0.50.5-0.5-0.40.40.5-0.10.50.5
Progressive ratio0.30.41.40.30.1-0.60.9-1.0-0.10.11.2-0.20.30.7
Food seeking constrained by brief footshock0.70.91.81.01.1-0.60.4-0.31.3-1.30.21.40.90.8
Seeking ratio, punishment vs. effort0.30.41.10.10.30.5-0.80.90.6-0.6-1.00.60.0-0.6
Retroperitoneal fat weight0.10.30.50.70.6-0.70.6-0.60.5-0.50.30.50.50.4
Reaction time number correct0.61.23.2-1.2-1.81.1-1.00.8-1.21.2-0.3-1.5-0.8-0.1
Reaction time mean minus median0.30.71.3-0.9-0.40.9-1.01.1-0.90.9-1.1-0.4-0.5-0.6
Reaction time mean minus median AUC0.00.10.1-0.20.10.3-0.30.3-0.30.3-0.40.10.1-0.2
Reaction time num false alarms0.71.02.00.90.5-0.81.1-1.20.8-0.81.10.71.21.4
Reaction time num false alarms AUC0.40.71.90.60.4-0.60.8-0.90.6-0.60.90.61.11.4
Reaction time trials correct on left0.61.23.2-1.2-1.81.1-1.00.8-1.21.2-0.3-1.5-0.8-0.1
Reaction time trials on left0.61.13.0-1.1-1.71.1-1.00.8-1.21.2-0.3-1.4-0.8-0.0
Reaction time mean0.10.20.40.20.60.1-0.30.40.4-0.4-0.50.60.0-0.4
Reaction time mean AUC0.10.20.50.20.70.1-0.30.40.4-0.4-0.50.6-0.0-0.4
Median of all reaction times0.40.61.30.91.1-0.40.3-0.21.1-1.10.11.10.5-0.1
Reaction time omissions0.30.41.40.41.2-0.50.3-0.30.6-0.60.10.90.60.5
Reaction time false alarm rate1.11.51.91.21.2-1.11.2-1.21.2-1.21.01.31.41.3
Reaction time premature initiation rate0.10.20.50.20.3-0.30.1-0.00.3-0.3-0.30.60.60.7
Reaction time premature initiations0.20.40.7-0.7-0.80.6-0.70.7-0.60.6-0.8-0.5-0.20.3
Std. dev. reaction times0.10.10.4-0.40.30.3-0.50.5-0.30.3-0.60.3-0.0-0.1
Reaction time trials completed0.61.13.0-1.1-1.71.1-1.00.8-1.21.2-0.3-1.4-0.8-0.0
Reaction time trials AUC0.61.23.0-1.1-1.71.1-0.90.7-1.21.2-0.2-1.5-0.8-0.2
Run reversals in cocaine runway, females2.72.63.4-1.5-1.71.7-1.61.5-1.71.7-1.4-1.4-1.8-1.8
Run reversals in cocaine runway, males0.30.30.50.70.1-0.60.7-0.70.6-0.60.7-0.00.50.3
Latency to leave start box in cocaine runway1.11.32.5-1.2-1.60.8-0.60.4-1.31.30.1-1.6-1.5-0.8
Latency to leave start box in cocaine runway, F2.12.46.1-1.6-2.51.4-1.10.8-1.61.6-0.2-2.4-1.6-0.7
Latency to leave start box in cocaine runway, M0.40.40.90.40.9-0.80.8-0.70.3-0.30.60.9-0.1-0.2
Std. dev. time between licks in bursts0.20.30.8-0.4-0.10.7-0.80.8-0.10.1-0.90.2-0.10.3
Total sessions with >9 infusions0.10.20.40.40.2-0.30.5-0.50.2-0.20.60.3-0.4-0.6
Short access day 1 total inactive lever presses1.92.54.31.32.1-1.81.8-1.81.3-1.31.81.61.11.0
Short access day 10 total inactive lever presses0.10.10.4-0.40.60.1-0.20.40.1-0.1-0.60.2-0.30.2
Short access day 1 total infusions0.40.51.20.80.6-0.90.9-1.00.5-0.51.10.4-0.1-0.4
Short access day 10 total infusions0.30.30.60.80.4-0.40.5-0.50.8-0.80.70.60.40.2
Short access total infusions0.20.20.70.60.2-0.40.6-0.70.4-0.40.80.20.00.0
Short access day 1 locomotion1.21.52.41.41.6-1.31.3-1.31.3-1.31.21.40.70.3
Short access day 10 total locomotion1.22.22.91.71.4-1.51.7-1.61.4-1.41.41.61.71.0
Short access total locomotion0.40.50.90.80.6-0.71.0-1.00.5-0.50.90.70.40.2
One hour access (0.3 mA shock)0.60.61.3-0.6-1.10.8-0.50.4-1.01.0-0.1-1.1-0.7-0.7
Compulsive drug intake0.50.64.2-0.2-0.60.6-0.50.5-0.40.4-0.6-0.4-1.0-2.0
One hour access (shock baseline)0.00.00.1-0.1-0.30.1-0.0-0.1-0.10.10.3-0.3-0.10.4
Social response proportion0.10.20.6-0.40.20.1-0.10.0-0.80.80.0-0.3-0.2-0.4
Social responses0.50.61.50.51.2-1.10.8-0.70.3-0.30.80.70.70.9
Social time0.20.21.9-0.20.2-0.0-0.20.2-0.10.1-0.10.00.61.4
Soleus weight0.10.31.40.10.4-0.30.4-0.4-0.20.20.3-0.31.11.2
Bone: stiffness0.00.00.20.1-0.40.3-0.0-0.00.1-0.10.1-0.30.10.4
Tibialis anterior weight1.34.45.8-2.4-1.92.2-2.32.2-2.32.3-2.0-2.2-1.7-0.8
Time to tail flick, vehicle, before self-admin0.20.30.80.20.9-0.2-0.10.10.5-0.5-0.20.80.60.6
Time to tail flick, vehicle, after self-admin0.10.10.5-0.1-0.10.00.0-0.0-0.30.3-0.1-0.20.50.7
Time to tail flick, test, before self-admin1.41.43.6-1.2-0.91.4-1.51.6-0.90.9-1.9-0.8-0.7-0.5
Time to tail flick, test, after self-admin0.60.61.20.71.0-0.60.5-0.40.8-0.80.10.90.81.1
Delta time to tail flick, vehicle, before/after SA0.40.41.90.4-0.1-0.50.6-0.60.2-0.20.5-0.11.01.4
Delta time to tail flick, test, before/after SA3.63.75.62.11.6-2.12.3-2.31.7-1.72.41.51.71.4
Tibia length1.13.03.9-1.9-2.01.9-1.81.8-1.91.9-1.7-1.9-1.1-0.1
Ambulatory time before self-admin0.10.10.40.2-0.60.20.1-0.20.4-0.40.4-0.3-0.20.6
Ambulatory time after self-admin1.11.23.1-1.1-0.61.4-1.51.6-0.50.5-1.8-0.5-1.10.0
Bone: tissue strength1.41.42.0-1.3-0.91.3-1.21.2-1.21.2-1.2-1.4-1.1-1.1
Total heroin consumption2.22.57.31.31.2-1.61.5-1.51.0-1.01.51.42.02.7
Bone: trabecular number5.89.612.63.03.4-3.53.1-3.03.0-3.02.83.13.32.7
Bone: trabecular spacing1.62.23.6-1.6-1.81.9-1.61.5-1.51.5-1.3-1.7-0.9-0.1
Bone: trabecular thickness0.20.20.60.20.8-0.60.2-0.20.4-0.40.30.50.40.5
Bone: trabecular tissue density0.40.63.6-0.2-0.20.5-0.30.4-0.60.6-0.6-0.5-1.0-1.9
Water consumed over 24 hours0.10.20.6-0.4-0.60.2-0.40.4-0.20.2-0.4-0.8-0.10.1
Number of responses in last shaping day0.40.41.00.61.0-0.50.4-0.30.9-0.90.11.0-0.2-0.5