Hub : Genes

Ikzf3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL isoform ratio XM_008768049.3 0.02 0.02 1.5e-03 0.01 0.02 0.02 0.01 9.4e-03 1.7e-03 5.0e-03 1.1e-02
2 NAcc alternative TSS NM_001107047.1 0.06 0.05 6.8e-06 0.05 0.04 0.04 0.04 4.4e-06 1.2e-05 1.5e-05 1.1e-05
3 NAcc alternative TSS XM_008768049.3 0.06 0.05 5.6e-06 0.04 0.04 0.04 0.04 5.2e-06 1.1e-05 7.9e-06 8.7e-06
4 Brain isoform ratio XM_008768049.3 0.06 0.05 2.1e-03 0.01 0.01 0 0.01 2.2e-02 8.4e-02 3.6e-01 4.2e-02
5 Brain alternative TSS NM_001107047.1 0.1 0.07 1.0e-04 0.02 0.02 0.02 0.02 2.3e-03 6.7e-03 7.1e-03 3.1e-03
6 Brain alternative TSS XM_008768049.3 0.1 0.07 1.2e-04 0.02 0.02 0.02 0.02 3.7e-03 6.8e-03 6.2e-03 3.8e-03
7 Liver gene expression Ikzf3 0.04 0.03 6.4e-05 0.03 0.03 0.02 0.03 3.3e-04 1.9e-04 1.1e-03 4.3e-04
8 NAcc isoform ratio XM_008768049.3 0.07 0.06 8.2e-08 0.06 0.06 0.06 0.06 7.9e-08 1.9e-07 4.1e-07 5.5e-08
9 Adipose gene expression Ikzf3 0.03 0.02 4.7e-04 0.02 0.02 0.02 0.02 1.3e-03 1.3e-03 2.3e-03 1.6e-03
10 NAcc gene expression Ikzf3 0.08 0.07 1.3e-08 0.09 0.07 0.08 0.09 2.7e-10 3.8e-08 5.6e-10 1.4e-10
11 PL gene expression Ikzf3 0.1 0.05 1.1e-10 0.09 0.1 0.1 0.1 1.0e-09 1.3e-10 8.5e-11 1.1e-10
12 PL alternative TSS NM_001107047.1 0.06 0.04 2.5e-05 0.02 0.04 0.02 0.02 3.1e-03 6.1e-05 1.8e-03 3.3e-03
13 PL alternative TSS XM_008768049.3 0.06 0.04 3.4e-05 0.02 0.03 0.02 0.02 4.1e-03 1.3e-04 2.5e-03 4.1e-03
14 OFC gene expression Ikzf3 0.28 0.17 7.6e-03 0 0.04 0.09 0.05 2.6e-01 4.8e-02 4.6e-03 2.7e-02
15 Brain gene expression Ikzf3 0.11 0.07 5.9e-05 0.02 0.04 0.04 0.05 2.4e-03 1.8e-04 6.2e-05 3.6e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density2.23.85.4-2.1-2.12.12.0-2.12.12.1-1.9-2.31.5-2.02.0-2.0-1.40.6
Area under the delay curve0.30.30.6-0.6-0.40.40.4-0.80.80.6-0.6-0.70.6-0.50.3-0.3-0.30.4
BMI with tail1.54.97.52.72.7-2.7-2.52.1-2.1-2.42.42.2-2.51.9-1.91.7-0.11.9
BMI without tail0.10.10.30.40.5-0.5-0.5-0.10.1-0.30.3-0.2-0.50.1-0.30.30.00.4
Body weight4.016.825.45.04.6-4.6-4.64.2-4.2-4.64.64.1-4.74.1-3.53.30.81.9
Weight adjusted by age0.40.41.40.40.6-0.6-0.71.2-1.2-0.20.70.8-0.60.40.1-0.2-0.50.5
Bone surface0.10.21.0-0.1-0.20.20.2-0.40.40.3-0.2-0.60.0-0.50.6-0.6-0.91.0
Bone volume0.50.82.5-0.5-0.70.70.7-0.70.70.8-0.5-0.90.3-1.01.1-1.1-1.51.6
Breakpoint value in progressive ratio session0.10.10.50.2-0.40.4-0.20.7-0.7-0.30.20.5-0.10.20.3-0.3-0.20.1
Number of licking bursts0.50.63.3-0.5-0.50.50.3-0.20.20.8-0.3-0.10.4-0.70.9-0.9-1.41.8
Context. condit. distance diff. score1.92.34.01.21.3-1.3-1.31.3-1.3-1.51.41.4-1.31.8-1.92.02.0-1.5
Locomotion velocity, session 10.30.30.60.70.7-0.7-0.60.8-0.8-0.60.40.6-0.40.3-0.30.2-0.10.5
Locomotion distance, session 11.62.03.51.91.6-1.6-1.71.8-1.8-1.61.41.4-1.51.0-1.00.8-0.10.9
Locomotion velocity, session 20.20.20.30.50.4-0.4-0.50.5-0.5-0.50.30.3-0.40.4-0.40.30.5-0.4
Locomotion distance, session 20.20.21.30.50.3-0.3-0.40.5-0.5-0.3-0.10.1-0.0-0.20.4-0.5-0.91.1
Locomotion velocity, session 30.10.10.5-0.0-0.30.30.2-0.10.1-0.20.3-0.6-0.40.2-0.10.10.6-0.7
Locomotion distance, session 30.20.30.70.50.5-0.5-0.40.6-0.6-0.50.70.1-0.80.5-0.40.40.3-0.2
Stereotopy head waving bouts, day 32.12.53.9-1.9-1.71.71.8-1.91.91.7-1.6-2.01.5-1.51.3-1.2-0.5-0.2
Stereotopy head waving duration, day 30.10.20.4-0.4-0.30.30.4-0.60.60.4-0.3-0.60.3-0.40.2-0.1-0.20.3
Locomotion velocity, session 70.90.92.11.11.2-1.2-1.11.4-1.4-0.90.81.1-0.80.7-0.60.50.00.4
Locomotion distance, session 70.40.51.10.70.8-0.8-0.81.1-1.1-0.60.11.00.10.3-0.50.50.4-0.2
Stereotopy head waving bouts, day 70.50.51.6-0.9-0.60.60.7-0.80.80.9-0.3-1.30.2-0.70.8-0.7-0.70.4
Stereotopy head waving duration, day 70.20.31.2-0.6-0.40.40.6-0.60.60.6-0.0-1.1-0.1-0.40.6-0.6-0.50.3
Locomotion velocity, session 87.08.410.33.23.1-3.1-3.13.1-3.1-3.22.93.1-2.93.0-3.02.91.9-0.6
Locomotion distance, session 81.11.62.21.51.4-1.4-1.41.5-1.5-1.41.21.4-1.21.2-1.21.10.60.1
Degree of sensitization distance1.01.02.51.01.1-1.1-1.11.2-1.2-1.00.51.6-0.20.8-1.11.10.8-0.4
Degree of sensitization stereotypy0.80.81.5-1.1-0.80.80.9-0.90.91.2-0.5-1.20.4-1.01.1-1.1-1.00.6
Conditioned locomotion0.20.21.4-0.4-0.40.40.2-0.20.20.3-0.6-0.20.6-0.30.2-0.10.6-1.2
Cocaine response after cond. corrected1.41.53.0-1.1-0.80.80.9-0.70.71.4-1.3-0.61.5-1.71.4-1.4-1.71.5
Cocaine response after cond. not corrected1.71.93.6-1.3-1.01.01.0-0.70.71.7-1.4-0.51.6-1.91.6-1.6-1.91.6
Cocaine response before conditioning0.10.10.2-0.5-0.40.40.3-0.10.10.4-0.2-0.10.3-0.20.1-0.10.2-0.5
Saline control response0.20.20.70.20.5-0.5-0.50.7-0.70.0-0.00.80.1-0.1-0.00.0-0.60.8
Bone: connectivity density2.94.66.9-2.4-2.32.32.3-2.32.32.4-2.2-2.61.9-2.22.2-2.2-1.20.0
Bone: cortical apparent density5.06.610.1-3.0-3.03.03.1-2.62.62.7-3.1-2.83.2-2.32.0-1.9-0.6-0.7
Bone: cortical area0.00.10.2-0.4-0.30.30.3-0.20.20.4-0.2-0.10.2-0.30.2-0.2-0.30.2
Bone: cortical porosity0.40.41.5-0.5-0.30.30.1-0.40.40.7-0.60.00.7-0.70.7-0.8-1.11.2
Bone: cortical porosity0.40.42.2-0.4-0.20.20.0-0.20.20.7-0.50.20.7-0.70.7-0.7-1.21.5
Bone: cortical thickness0.61.12.1-1.4-1.31.31.2-0.80.81.3-1.2-1.01.1-0.90.8-0.7-0.2-0.6
Bone: cortical thickness4.04.76.8-2.6-2.62.62.6-2.22.22.4-2.4-2.32.3-1.91.9-1.8-0.7-0.8
Bone: cortical tissue density5.06.610.2-3.0-2.92.93.1-2.72.72.7-3.1-2.83.2-2.32.0-1.9-0.6-0.7
Condit. Reinf. active minus inactive responses0.60.71.2-1.0-1.11.10.9-0.70.70.8-1.0-1.00.8-0.70.6-0.50.4-1.1
Condit. Reinf. active-inactive response ratio0.80.93.1-1.1-1.11.10.9-0.80.80.7-0.9-1.00.8-0.40.4-0.30.8-1.8
Condit. Reinf. active responses0.60.71.2-1.1-1.11.10.9-0.70.70.9-1.0-0.90.9-0.80.7-0.70.1-0.7
Condit. Reinf. inactive responses0.20.20.8-0.5-0.40.40.3-0.10.10.6-0.3-0.10.4-0.50.6-0.6-0.80.9
Incentive salience index mean1.61.92.7-1.6-1.61.61.5-1.41.41.4-1.7-1.51.5-1.41.3-1.2-0.3-0.5
Condit. Reinf. lever presses1.01.42.4-1.2-1.11.11.1-1.01.01.3-1.5-1.01.5-1.51.2-1.2-0.80.3
Condit. Reinf. active minus inactive responses1.01.31.8-1.2-1.21.21.3-1.11.11.2-0.9-1.31.0-1.01.3-1.3-1.10.6
Condit. Reinf. active-inactive response ratio1.11.21.8-1.0-1.11.11.1-1.11.11.0-0.9-1.30.8-1.01.3-1.3-1.30.8
Condit. Reinf. active responses1.92.73.6-1.6-1.61.61.8-1.61.61.6-1.4-1.81.4-1.51.9-1.9-1.81.3
Condit. Reinf. inactive responses2.22.73.3-1.6-1.61.61.7-1.61.61.7-1.7-1.61.8-1.71.8-1.8-1.61.3
Condit. Reinf. lever presses0.10.10.3-0.3-0.30.30.4-0.40.40.3-0.2-0.50.3-0.00.2-0.2-0.20.1
Condit. Reinf. lever reinforcers received1.82.63.4-1.6-1.61.61.9-1.61.61.6-1.5-1.81.5-1.51.8-1.8-1.61.0
Conditioned reinforcement - actives0.40.40.8-0.9-0.80.80.7-0.20.20.9-0.70.20.9-0.60.7-0.6-0.4-0.1
Conditioned reinforcement - inactives1.82.03.5-1.5-1.91.91.7-1.71.71.3-1.6-1.31.7-1.21.1-1.1-0.3-0.3
Conditioned locomotion0.40.51.0-0.9-0.70.70.40.2-0.21.0-0.7-0.20.8-0.80.8-0.8-0.90.6
Patch foraging indifference point 0 sec1.62.53.6-1.7-1.71.71.8-1.91.91.5-1.9-1.91.8-1.61.1-1.00.0-1.1
Patch foraging indifference point AUC0.10.10.30.10.2-0.2-0.30.6-0.6-0.1-0.10.20.1-0.2-0.00.00.10.1
Delay disc. indifference point, 0s delay1.11.21.9-1.2-1.11.11.0-1.01.01.2-1.3-1.41.3-1.31.0-0.9-0.80.6
Delay disc. indifference point, 16s delay0.40.41.2-0.6-0.30.30.5-0.90.90.4-0.8-0.30.8-0.3-0.20.30.9-1.1
Delay disc. indifference point, 2s delay1.51.73.3-1.3-1.01.01.0-0.80.81.5-1.4-1.11.4-1.41.3-1.3-1.81.7
Delay disc. indifference point, 24s delay0.10.10.30.10.3-0.3-0.4-0.30.3-0.10.10.1-0.10.2-0.40.50.6-0.5
Delay disc. indifference point, 4s delay0.80.81.2-1.0-0.90.90.8-0.80.81.0-0.9-0.60.9-0.80.9-0.9-1.11.0
Delay disc. indifference point, 8s delay0.20.20.6-0.4-0.20.20.1-0.80.80.4-0.3-0.60.2-0.40.2-0.20.1-0.2
Indifference point function ln k0.20.21.40.00.3-0.30.0-0.20.2-0.20.2-0.1-0.30.4-0.50.60.8-1.2
Indifference point function log k0.20.21.40.00.3-0.30.0-0.20.2-0.20.2-0.1-0.30.4-0.50.60.8-1.2
Patch foraging total patch changes 0 sec1.21.92.9-1.5-1.41.41.5-1.61.61.2-1.7-1.71.5-1.40.9-0.80.2-1.2
Patch foraging total patch changes 12 sec5.47.08.8-2.8-3.03.02.5-2.62.62.8-2.8-2.82.8-3.02.7-2.7-1.91.0
Patch foraging total patch changes 18 sec0.50.61.1-0.9-0.80.80.9-0.60.60.8-0.9-1.10.9-0.90.7-0.6-0.2-0.1
Patch foraging total patch changes 24 sec1.31.52.3-1.5-1.51.51.3-0.80.81.5-1.5-1.31.5-1.41.2-1.1-0.1-0.8
Patch foraging total patch changes 6 sec2.23.35.0-1.8-2.02.02.0-2.02.01.7-2.2-2.22.1-2.01.5-1.5-0.8-0.0
Patch foraging time to switch 0 sec0.10.10.3-0.3-0.30.30.4-0.40.40.4-0.3-0.50.3-0.40.5-0.5-0.20.3
Patch foraging water rate 0 sec0.10.10.2-0.2-0.40.40.5-0.40.40.1-0.3-0.40.2-0.10.1-0.1-0.2-0.3
Patch foraging water rate 12 sec0.20.31.30.30.2-0.2-0.50.7-0.7-0.40.61.1-0.50.7-0.40.40.6-0.7
Patch foraging water rate 18 sec0.50.71.4-0.9-0.90.90.5-0.70.70.9-0.6-0.50.4-0.81.0-1.0-1.20.7
Patch foraging water rate 24 sec0.71.01.8-0.9-1.11.11.3-1.41.40.8-0.9-1.00.7-0.80.8-0.8-1.00.5
Patch foraging water rate 6 sec1.52.22.9-1.5-1.71.71.7-1.61.61.5-1.7-1.21.6-1.51.5-1.5-1.10.1
Seeking ratio, delayed vs. immediate footshock0.40.41.4-0.4-0.50.50.60.4-0.40.0-0.90.91.10.1-0.30.40.9-1.2
Distance traveled before self-admin0.20.21.10.2-0.00.00.2-0.10.1-0.1-0.00.90.3-0.10.2-0.3-1.11.1
Distance traveled after self-admin0.90.91.81.41.1-1.1-0.90.6-0.6-1.31.20.9-1.21.1-0.90.8-0.10.4
Extensor digitorum longus weight8.734.440.56.46.3-6.3-6.26.3-6.3-6.36.16.2-6.06.1-5.95.84.2-2.0
Bone: elastic displacement0.00.00.0-0.0-0.10.1-0.00.1-0.10.00.1-0.1-0.20.1-0.10.10.10.1
Bone: elastic work0.20.21.0-0.2-0.40.40.3-0.20.20.3-0.2-0.30.1-0.30.4-0.5-0.81.0
Bone: endosteal estimation1.42.95.12.32.2-2.2-1.91.5-1.5-1.91.91.9-1.91.4-1.21.1-0.11.4
Bone: endosteal perimeter0.91.83.21.81.7-1.7-1.51.1-1.1-1.71.51.6-1.41.2-1.11.00.40.3
Epididymis fat weight0.10.20.70.50.2-0.2-0.30.7-0.7-0.40.40.7-0.40.30.1-0.1-0.70.8
Delta time in closed arm before/after self-admin3.23.14.42.01.8-1.8-2.02.1-2.1-1.92.00.9-2.12.0-1.71.61.1-0.2
Delta time in open arm before/after self-admin0.10.10.6-0.1-0.10.10.0-0.10.10.0-0.10.80.2-0.1-0.10.1-0.20.4
Diff in mean of infusions in LGA sessions0.20.20.70.3-0.20.2-0.50.8-0.8-0.30.70.6-0.70.60.1-0.1-0.0-0.1
Delay discount exponential model param0.10.10.40.40.2-0.2-0.20.6-0.6-0.40.40.5-0.30.3-0.20.10.2-0.4
Extinction: sum of active levers before priming1.31.32.61.31.4-1.4-1.61.0-1.0-1.11.41.2-1.51.0-1.00.90.50.3
Active lever presses in extinction session 63.13.08.5-1.1-1.11.11.1-1.21.21.4-1.5-1.01.5-2.12.0-2.1-2.92.8
Bone: final force1.01.64.0-1.0-0.90.90.9-0.90.91.3-1.1-0.81.1-1.41.4-1.4-2.02.0
Bone: final moment0.81.34.3-0.9-0.70.70.7-0.80.81.2-0.9-0.70.9-1.21.2-1.3-1.92.1
Food consumed during 24 hour testing period0.60.71.21.00.6-0.6-1.00.7-0.7-0.91.10.8-1.11.0-0.80.80.10.4
Glucose0.30.41.8-0.5-0.20.20.2-0.00.00.6-1.10.21.3-0.90.4-0.4-0.80.9
Heart weight2.73.85.62.42.2-2.2-2.02.2-2.2-2.31.81.8-1.81.9-2.12.10.80.5
Delay discount hyperbolic model param0.20.30.50.60.3-0.3-0.30.7-0.7-0.60.60.6-0.50.5-0.30.30.4-0.5
Intermittent access intake day 1-15 change0.40.41.0-0.7-1.01.00.6-0.80.80.5-0.5-1.00.4-0.20.6-0.6-0.0-0.2
Intermittent access intake escalation0.40.40.9-0.6-1.01.00.5-0.80.80.5-0.5-0.90.4-0.20.7-0.7-0.2-0.0
Intermittent access intake escalation 20.00.00.1-0.0-0.40.4-0.2-0.30.30.00.1-0.2-0.20.20.2-0.2-0.10.2
Intermitt. access day 1 inactive lever presses2.52.75.3-1.4-1.71.71.6-2.22.21.3-1.7-2.31.4-1.41.5-1.5-1.10.6
Intermitt. access day 15 inactive lever presses4.14.57.2-2.3-2.42.42.1-2.42.42.2-2.3-2.72.2-1.81.9-1.8-1.10.1
Intermitt. access escalation Index2.21.94.41.31.5-1.5-1.41.0-1.0-1.22.01.3-2.11.7-1.21.20.8-0.1
Intermittent access day 1 total infusions0.30.30.6-0.4-0.70.70.7-0.20.20.5-0.5-0.00.7-0.60.5-0.5-0.80.6
Intermittent access day 15 total infusions0.50.61.4-0.8-1.21.20.9-0.80.80.7-0.8-0.80.9-0.50.7-0.7-0.30.0
Intermittent access terminal intake (last 3 days)0.70.81.6-0.9-1.21.21.0-1.01.00.8-0.8-0.80.8-0.70.8-0.8-0.50.3
Intermittent access total infusions0.20.20.7-0.4-0.80.80.7-0.40.40.3-0.4-0.20.6-0.30.4-0.4-0.40.2
Intermittent access day 1 locomotion0.30.30.9-0.5-0.50.50.80.0-0.00.5-0.8-0.31.0-0.70.4-0.3-0.30.1
Intermittent access day 15 total locomotion0.40.50.6-0.7-0.70.70.7-0.10.10.7-0.8-0.80.7-0.80.6-0.6-0.80.6
Intermittent access total locomotion0.60.71.2-1.0-1.01.01.1-0.50.50.9-1.0-0.91.1-0.80.7-0.7-0.3-0.2
Intermittent access standard deviation1.71.83.9-1.3-2.02.01.5-1.61.61.1-1.3-1.61.2-0.81.2-1.20.1-0.8
Left kidney weight1.13.24.72.01.9-1.9-1.61.3-1.3-2.22.01.0-2.22.1-1.91.91.8-1.2
Right kidney weight0.10.41.20.80.6-0.6-0.50.5-0.5-0.70.90.3-1.10.6-0.30.2-0.00.4
Cocaine induced anxiety1.51.74.31.61.5-1.5-1.51.0-1.0-1.31.90.9-2.11.0-0.80.7-0.61.5
Post-drug Anxiety0.20.20.80.40.5-0.5-0.40.3-0.3-0.20.60.4-0.6-0.0-0.10.1-0.60.9
Baseline Anxiety1.11.23.0-1.4-1.11.11.2-0.70.71.3-1.6-0.61.7-1.10.6-0.50.3-1.0
Tail length0.30.81.21.00.7-0.7-1.00.9-0.9-1.10.90.7-0.91.0-0.80.81.1-1.0
Length with tail2.59.112.53.53.1-3.1-3.23.3-3.3-3.53.23.0-3.33.3-2.82.71.9-0.6
Length without tail3.06.59.83.12.7-2.7-2.72.9-2.9-2.92.73.0-2.72.7-2.12.00.60.8
Times rat made contact with spout1.21.41.9-1.1-1.31.31.1-1.41.41.2-0.8-1.30.7-1.11.2-1.2-1.21.4
Lifetime Intake0.30.30.9-0.4-0.90.90.8-0.40.40.3-0.4-0.30.6-0.30.5-0.5-0.40.2
Liver weight, left0.00.00.1-0.0-0.30.30.00.1-0.10.0-0.10.00.20.10.2-0.2-0.1-0.1
Liver weight, right0.40.70.9-0.7-0.90.90.9-0.90.90.7-0.9-0.90.9-0.80.9-0.9-0.4-0.0
Locomotor activity0.81.22.9-1.0-1.21.20.9-0.80.81.2-0.7-0.50.6-1.01.4-1.4-1.71.3
Locomotor testing distance2.03.44.5-2.1-2.12.12.0-2.02.02.1-1.6-1.71.5-1.81.9-1.9-1.60.5
Locomotor testing rearing5.48.312.1-3.2-3.23.23.4-3.53.53.0-3.0-3.32.9-2.82.5-2.4-1.0-0.7
Locomotion in novel chamber5.26.411.3-2.9-2.62.62.9-1.81.82.9-3.2-1.73.4-3.02.6-2.5-2.31.1
Locomotion in novel chamber post-restriction1.82.26.7-1.2-1.21.21.0-1.11.11.4-1.1-1.10.9-1.51.7-1.7-2.62.1
Fecal boli incidents, locomotor time 10.20.20.60.50.7-0.7-0.10.8-0.8-0.40.20.7-0.10.1-0.30.3-0.30.6
Change in fecal boli incidents, locomotor task0.10.10.30.00.0-0.0-0.50.4-0.4-0.0-0.10.30.20.0-0.20.20.1-0.0
Time >=10cm from walls, locomotor time 10.30.31.8-0.5-0.20.20.20.1-0.10.4-0.7-0.30.7-0.4-0.10.10.9-1.4
Bouts of movement, locomotor time 10.50.51.70.80.7-0.7-0.70.5-0.5-0.71.2-0.0-1.30.9-0.50.40.4-0.3
Total resting periods, locomotor time 10.91.02.41.11.1-1.1-1.11.0-1.0-1.01.50.4-1.51.1-0.70.60.20.1
Rest time, locomotor task time 10.10.10.7-0.0-0.00.00.2-0.60.60.20.2-0.8-0.3-0.10.3-0.4-0.50.4
Distance moved, locomotor task time 10.10.10.8-0.3-0.30.30.50.0-0.00.3-0.60.20.9-0.50.2-0.10.10.0
Vertical activity count, locomotor time 10.40.41.70.30.1-0.1-0.51.3-1.3-0.3-0.01.30.30.0-0.30.3-0.00.5
Time >=10cm from walls, locomotor time 21.01.03.1-1.3-0.90.90.80.2-0.21.3-1.50.21.8-1.41.0-1.0-0.4-0.1
Bouts of movement, locomotor time 20.30.32.5-0.3-0.10.10.3-0.40.40.2-0.2-0.70.1-0.00.1-0.00.9-1.6
Total resting periods, locomotor time 20.30.33.0-0.10.0-0.00.1-0.20.2-0.00.0-0.5-0.10.2-0.20.21.2-1.7
Rest time, locomotor task time 20.70.81.11.11.1-1.1-1.01.0-1.0-1.01.00.7-1.00.9-0.80.70.40.0
Distance moved, locomotor task time 20.10.10.30.10.3-0.30.00.3-0.3-0.0-0.40.10.5-0.5-0.10.0-0.00.3
Vertical activity count, locomotor time 20.30.31.00.50.5-0.5-0.61.0-1.0-0.40.20.8-0.10.1-0.50.50.30.1
Light reinforcement 12.85.28.7-2.4-2.52.52.5-2.72.72.3-2.1-3.01.8-2.12.2-2.2-1.50.3
Light reinforcement 21.01.32.9-0.9-1.01.00.9-1.01.01.1-1.0-1.40.9-1.31.2-1.2-1.71.4
Bone: marrow area1.32.74.82.22.1-2.1-1.91.5-1.5-1.91.91.8-1.81.3-1.21.0-0.11.3
Bone: maximum diameter0.10.10.3-0.2-0.10.10.2-0.40.40.3-0.1-0.10.2-0.40.4-0.4-0.50.5
Bone: maximum force0.10.22.00.10.2-0.2-0.10.0-0.00.2-0.10.1-0.0-0.30.3-0.3-1.01.4
Bone: maximum moment0.10.22.10.20.3-0.3-0.30.1-0.1-0.00.10.2-0.2-0.10.1-0.1-0.91.5
Mean time between licks in bursts1.01.42.51.41.4-1.4-1.20.9-0.9-1.31.60.9-1.51.4-1.01.00.20.5
Mean num. licks in bursts0.20.20.7-0.3-0.50.50.5-0.70.70.2-0.3-0.80.2-0.20.0-0.00.3-0.7
Cd content in liver0.20.20.5-0.3-0.40.40.4-0.60.60.3-0.2-0.70.0-0.40.3-0.3-0.40.4
Co content in liver0.70.81.50.90.7-0.7-0.70.8-0.8-1.11.00.6-1.01.1-1.01.01.2-0.9
Cu content in liver0.10.10.90.2-0.20.20.10.0-0.0-0.5-0.0-0.20.00.3-0.30.30.8-1.0
Fe content in liver0.70.91.41.21.0-1.0-1.11.1-1.1-1.01.10.9-1.10.8-0.70.70.10.5
K content in liver1.31.32.1-1.2-1.31.31.1-1.11.11.1-1.4-1.01.4-1.21.2-1.2-0.6-0.0
Mg content in liver0.90.92.8-1.0-1.11.10.8-1.01.00.7-1.1-0.71.1-0.50.4-0.30.8-1.7
Mn content in liver1.82.02.9-1.6-1.71.71.5-1.71.71.3-1.5-1.61.4-1.31.2-1.20.1-1.0
Na content in liver0.70.72.1-0.6-0.60.60.4-0.50.50.8-0.6-0.40.7-1.11.1-1.2-1.41.4
Rb content in liver1.41.82.7-1.4-1.41.41.5-1.51.51.3-1.7-1.51.6-1.41.1-1.0-0.5-0.0
Se content in liver4.85.88.1-2.6-2.82.82.7-2.82.82.4-2.5-2.52.6-2.42.3-2.2-0.9-0.3
Sr content in liver0.10.10.8-0.1-0.30.30.3-0.20.2-0.1-0.10.00.20.1-0.10.10.6-0.9
Zn content in liver3.03.34.9-1.9-2.12.12.1-2.22.21.8-1.5-2.11.5-1.71.8-1.7-1.10.4
Bone: minimum diameter0.40.71.11.01.1-1.1-0.90.7-0.7-0.80.91.1-0.80.5-0.60.5-0.20.8
Time in familiar zone, hab. session 11.31.25.0-0.5-0.50.50.7-0.80.80.8-0.7-0.60.9-1.31.1-1.2-2.02.2
Time in novel zone, hab. session 10.60.62.9-0.8-0.60.60.6-0.50.50.5-0.7-1.10.5-0.1-0.10.21.1-1.7
Total zone transitions, hab. session 11.62.22.91.71.6-1.6-1.51.5-1.5-1.71.61.4-1.61.6-1.51.51.2-0.7
Total locomotion distance, hab. session 10.00.10.20.1-0.20.20.10.1-0.1-0.20.2-0.2-0.30.3-0.30.30.3-0.4
Locomotion velocity, hab. session 10.40.51.00.70.4-0.4-0.50.6-0.6-0.81.00.5-1.01.0-0.70.70.6-0.6
Time in familiar zone, hab. session 20.90.92.0-0.7-0.80.80.8-0.90.90.8-0.9-0.80.9-1.11.0-1.0-1.21.4
Time in novel zone, hab. session 20.20.21.2-0.4-0.30.30.4-0.30.30.2-0.2-0.50.10.10.1-0.10.5-1.1
Total zone transitions, hab. session 20.70.91.71.11.2-1.2-1.21.3-1.3-1.00.61.2-0.60.7-0.90.80.40.0
Total locomotion distance, hab. session 20.20.20.80.50.4-0.4-0.40.6-0.6-0.40.50.3-0.60.2-0.20.1-0.50.9
Locomotion velocity, hab. session 20.30.40.80.80.6-0.6-0.70.9-0.9-0.60.70.6-0.80.5-0.40.4-0.30.7
Novel to familiar place preference ratio1.71.73.11.11.2-1.2-1.21.1-1.1-1.21.41.2-1.31.5-1.31.31.6-1.8
Novelty place preference1.71.84.21.01.1-1.1-1.11.0-1.0-1.11.41.2-1.21.5-1.31.41.8-2.0
Time in novel zone, NPP test0.90.93.40.50.7-0.7-0.70.6-0.6-0.71.00.7-0.91.1-0.91.01.5-1.8
Total zone transitions, NPP test0.40.51.40.80.9-0.9-0.80.8-0.8-0.60.21.0-0.20.2-0.30.2-0.51.2
Total locomotion distance, NPP test0.10.21.20.0-0.00.00.10.0-0.00.1-0.2-0.20.1-0.40.3-0.4-0.91.1
Locomotion velocity, NPP test0.20.30.60.70.5-0.5-0.50.6-0.6-0.50.40.4-0.50.3-0.30.2-0.40.8
Intraocular pressure2.33.24.81.92.2-2.2-1.71.8-1.8-1.82.01.9-1.91.7-1.81.81.1-0.3
Delta distance traveled before/after self-admin1.51.62.31.31.3-1.3-1.41.2-1.2-1.31.40.7-1.51.3-1.31.31.3-0.9
Delta ambulatory time before/after self-admin0.91.02.41.11.3-1.3-1.30.7-0.7-1.01.30.1-1.60.9-1.00.90.8-0.4
Parametrial fat weight1.93.75.0-1.7-2.12.11.9-2.22.21.8-1.4-2.11.2-1.62.2-2.2-2.11.3
Pavlov. Cond. lever latency3.44.35.72.01.9-1.9-1.92.0-2.0-2.22.11.9-2.12.4-2.32.42.3-1.7
Pavlov. Cond. magazine entry latency9.612.415.0-3.8-3.63.63.7-3.73.73.9-3.5-3.53.5-3.73.7-3.6-2.81.6
Pavlov. Cond. change in total contacts7.68.111.4-3.3-3.13.13.2-3.43.43.0-3.1-3.22.9-2.82.6-2.4-1.2-0.0
Pavlov. Cond. index score8.410.712.9-3.4-3.23.23.3-3.33.33.6-3.3-3.23.3-3.63.5-3.5-2.92.0
Pavlov. Cond. latency score6.68.410.4-3.0-2.82.82.9-2.92.93.2-2.9-2.72.9-3.23.1-3.1-2.81.9
Pavlov. Cond. lever contacts2.93.54.8-1.8-1.61.61.7-1.81.82.0-1.7-1.61.8-2.12.1-2.2-2.21.8
Pavlov. Cond. magazine entry number11.714.617.64.24.0-4.0-4.14.2-4.2-4.23.94.0-3.84.0-3.83.82.8-1.5
Pavlov. Cond. intertrial magazine entries1.72.12.61.41.4-1.4-1.51.6-1.6-1.51.31.4-1.31.4-1.51.51.6-1.1
Pavlov. Cond. lever-magazine prob. diff.9.111.313.6-3.6-3.43.43.5-3.53.53.7-3.5-3.33.4-3.73.5-3.5-2.81.7
Pavlov. Cond. response bias8.710.612.8-3.6-3.43.43.5-3.53.53.6-3.4-3.43.3-3.53.3-3.2-2.31.2
Pavlov. Cond. lever latency0.40.61.30.70.8-0.8-0.80.8-0.8-0.70.50.8-0.50.4-0.70.71.1-1.2
Pavlov. Cond. magazine entry latency0.10.20.90.2-0.20.2-0.30.5-0.5-0.10.40.4-0.30.3-0.0-0.0-0.71.0
Pavlov. Cond. change in total contacts0.60.81.3-1.0-1.01.01.1-1.01.00.9-1.0-1.01.1-0.70.7-0.7-0.70.5
Pavlov. Cond. index score0.30.41.6-0.5-0.60.60.6-0.50.50.6-0.3-0.60.4-0.40.6-0.6-1.21.3
Pavlov. Cond. latency score0.20.31.5-0.3-0.50.50.4-0.30.30.4-0.1-0.40.2-0.20.5-0.5-1.01.2
Pavlov. Cond. lever contacts1.01.42.7-1.1-1.11.11.1-1.21.21.2-0.8-1.20.9-0.91.2-1.2-1.71.7
Pavlov. Cond. magazine entry number0.10.10.70.20.4-0.4-0.2-0.00.0-0.30.10.3-0.10.1-0.30.30.8-0.8
Pavlov. Cond. intertrial magazine entries2.33.05.61.41.6-1.6-1.51.5-1.5-1.71.61.6-1.61.9-1.81.92.4-2.2
Pavlov. Cond. lever-magazine prob. diff.0.20.31.5-0.3-0.50.50.4-0.30.30.4-0.2-0.50.2-0.20.5-0.5-1.11.2
Pavlov. Cond. response bias1.41.93.1-1.3-1.41.41.3-1.31.31.4-1.1-1.31.2-1.21.4-1.4-1.81.7
Time in closed arm before self-admin1.21.44.2-1.1-0.90.91.5-2.12.10.9-1.1-1.61.0-0.90.4-0.30.1-0.8
Time in closed arm after self-admin1.01.03.10.80.8-0.8-0.30.1-0.1-1.00.8-0.1-0.91.2-1.31.41.8-1.7
Time in open arm before self-admin2.12.26.21.51.1-1.1-1.82.5-2.5-1.41.41.8-1.21.4-1.00.90.9-0.4
Time in open arm after self-admin0.50.62.60.70.4-0.4-1.01.2-1.2-0.60.51.6-0.30.6-0.40.40.20.1
Bone: periosteal estimation0.20.31.30.70.7-0.7-0.50.3-0.3-0.50.60.6-0.60.2-0.20.1-0.61.1
Bone: periosteal perimeter0.40.71.21.11.0-1.0-0.90.6-0.6-0.91.01.0-1.00.6-0.50.4-0.41.1
Bone: post-yield work1.31.82.61.51.6-1.6-1.61.2-1.2-1.41.51.2-1.61.4-1.31.30.60.1
Progressive ratio test 1 active lever presses0.50.51.2-0.9-0.70.71.1-0.80.80.8-0.7-0.70.8-0.80.5-0.5-0.3-0.2
Progressive ratio test 1 breakpoint0.40.41.0-0.8-0.60.61.0-0.70.70.8-0.6-0.70.7-0.70.5-0.4-0.3-0.1
Progressive ratio test 1 inactive lever presses1.61.73.8-1.3-1.51.51.5-1.81.81.1-1.2-1.91.1-1.01.0-0.9-0.1-0.6
Progressive ratio test 2 active lever presses1.11.22.0-1.3-1.41.41.3-1.11.11.2-1.2-0.61.4-1.01.0-0.9-0.4-0.2
Progressive ratio test 2 breakpoint0.80.81.5-1.1-1.21.21.1-0.90.91.0-1.0-0.41.1-0.90.8-0.8-0.3-0.2
Progressive ratio test 2 inactive lever presses0.60.71.4-0.8-1.21.21.0-0.80.80.7-0.9-0.71.1-0.70.7-0.7-0.40.1
Incentive Sensitization - Responses1.41.42.4-1.3-1.51.51.2-1.11.11.2-1.4-0.61.6-1.11.2-1.1-0.70.2
Incentive Sensitization - Breakpoint1.31.42.4-1.3-1.41.41.2-1.11.11.2-1.3-0.61.5-1.11.2-1.2-0.80.3
Sum of active levers in priming session hrs 5-60.50.51.0-0.6-0.60.60.5-0.40.40.7-0.8-0.50.8-1.00.7-0.8-0.70.7
Progressive ratio0.30.31.2-0.3-0.20.20.50.2-0.20.4-0.90.21.1-0.70.6-0.7-0.70.5
Food seeking constrained by brief footshock0.50.61.4-0.5-0.50.50.4-1.21.20.6-0.3-1.00.3-0.80.8-0.8-0.90.8
Seeking ratio, punishment vs. effort0.20.20.6-0.00.0-0.0-0.2-0.80.80.00.6-0.5-0.80.3-0.30.30.3-0.2
Retroperitoneal fat weight0.00.10.70.40.2-0.20.0-0.10.1-0.40.1-0.0-0.20.1-0.20.1-0.50.9
Reaction time number correct0.70.92.41.00.7-0.7-0.91.4-1.4-0.90.91.5-0.61.0-0.70.6-0.51.1
Reaction time mean minus median0.40.51.10.50.7-0.7-0.80.8-0.8-0.51.00.2-1.00.8-0.60.60.7-0.4
Reaction time mean minus median AUC0.00.00.2-0.10.2-0.2-0.20.2-0.20.10.4-0.3-0.40.2-0.10.10.2-0.2
Reaction time num false alarms0.81.11.7-0.9-0.90.91.0-0.90.91.1-1.0-0.81.1-1.21.2-1.2-1.31.1
Reaction time num false alarms AUC0.60.91.8-0.8-0.80.80.8-0.70.71.0-0.8-0.70.8-1.01.1-1.2-1.31.1
Reaction time trials correct on left0.70.92.41.00.7-0.7-0.91.4-1.4-0.90.91.5-0.61.0-0.70.6-0.51.1
Reaction time trials on left0.60.92.31.00.7-0.7-0.81.4-1.4-0.90.91.5-0.61.0-0.70.6-0.51.1
Reaction time mean0.20.31.2-0.5-0.60.60.2-0.50.50.30.2-0.8-0.40.30.1-0.10.7-1.1
Reaction time mean AUC0.20.31.3-0.4-0.60.60.2-0.40.40.20.2-0.8-0.40.30.1-0.10.8-1.1
Median of all reaction times0.70.91.7-1.1-1.31.30.9-1.21.20.9-0.4-1.30.3-0.30.7-0.70.3-1.0
Reaction time omissions1.11.42.1-1.3-1.41.41.2-1.31.31.3-1.0-1.40.9-1.11.3-1.3-1.00.5
Reaction time false alarm rate1.01.41.8-1.2-1.01.01.2-1.31.31.3-1.1-1.31.0-1.31.3-1.3-0.90.4
Reaction time premature initiation rate0.30.51.0-0.7-0.90.90.4-0.20.20.7-0.3-0.50.1-0.40.9-0.9-1.00.8
Reaction time premature initiations0.20.31.60.1-0.30.3-0.40.7-0.7-0.00.50.5-0.50.40.2-0.2-1.01.3
Std. dev. reaction times0.10.10.4-0.00.1-0.1-0.30.2-0.2-0.00.5-0.4-0.60.4-0.00.00.4-0.3
Reaction time trials completed0.60.92.31.00.7-0.7-0.81.4-1.4-0.90.91.5-0.61.0-0.70.6-0.51.1
Reaction time trials AUC0.60.92.41.00.7-0.7-0.81.4-1.4-0.90.81.5-0.51.0-0.70.7-0.30.9
Run reversals in cocaine runway, females3.53.34.91.71.3-1.3-1.71.8-1.8-1.91.92.0-1.82.2-2.12.12.1-1.4
Run reversals in cocaine runway, males0.60.61.0-0.8-0.80.80.7-0.80.80.8-1.0-0.21.0-0.80.6-0.6-0.70.5
Latency to leave start box in cocaine runway1.41.52.51.51.1-1.1-1.01.5-1.5-1.50.81.6-0.71.3-1.41.30.80.0
Latency to leave start box in cocaine runway, F1.41.53.81.51.1-1.1-1.11.6-1.6-1.41.02.0-0.81.3-1.21.10.40.5
Latency to leave start box in cocaine runway, M0.30.31.1-0.2-0.40.40.7-0.60.6-0.0-0.7-1.10.6-0.2-0.10.20.6-0.8
Std. dev. time between licks in bursts0.10.10.40.30.3-0.3-0.3-0.00.0-0.20.5-0.1-0.60.30.1-0.1-0.40.4
Total sessions with >9 infusions0.60.71.4-0.9-0.90.90.9-1.11.10.7-0.8-1.20.8-0.60.4-0.30.5-0.9
Short access day 1 total inactive lever presses2.12.44.3-1.6-2.12.11.7-1.31.31.5-1.7-1.91.7-1.41.4-1.4-0.80.2
Short access day 10 total inactive lever presses0.10.10.40.4-0.20.2-0.50.1-0.1-0.40.4-0.2-0.70.5-0.10.10.30.0
Short access day 1 total infusions0.70.81.9-0.8-1.11.11.4-1.11.10.6-1.0-0.91.1-0.60.5-0.5-0.0-0.4
Short access day 10 total infusions0.50.50.9-0.6-0.90.90.9-0.60.60.7-0.5-0.40.7-0.70.7-0.8-1.00.8
Short access total infusions0.30.30.9-0.5-0.90.90.8-0.60.60.3-0.4-0.40.5-0.20.4-0.40.0-0.3
Short access day 1 locomotion3.84.17.6-2.1-2.32.32.3-2.52.51.9-2.0-2.82.0-1.81.8-1.7-0.7-0.2
Short access day 10 total locomotion1.31.52.2-1.4-1.11.11.5-1.11.11.4-1.4-1.21.5-1.41.2-1.2-0.90.2
Short access total locomotion0.50.51.0-0.7-0.90.91.0-0.70.70.5-0.9-0.90.9-0.40.3-0.30.4-0.8
One hour access (0.3 mA shock)0.10.10.2-0.0-0.10.10.20.3-0.3-0.00.10.40.00.4-0.10.10.3-0.5
Compulsive drug intake1.21.34.90.60.6-0.6-0.60.7-0.7-0.80.70.6-0.71.3-1.21.32.2-2.2
One hour access (shock baseline)0.50.61.3-0.6-0.80.80.8-0.50.50.6-0.7-0.30.8-0.70.8-0.9-1.11.0
Social response proportion0.20.30.60.50.8-0.8-0.60.6-0.6-0.50.10.5-0.10.2-0.60.60.20.2
Social responses0.30.41.5-0.2-0.10.10.2-0.50.50.4-0.7-0.30.6-0.90.5-0.5-1.01.2
Social time0.30.43.50.2-0.10.1-0.2-0.10.10.20.10.1-0.1-0.40.6-0.7-1.41.9
Soleus weight0.20.53.7-0.20.1-0.1-0.30.1-0.10.6-0.20.10.1-0.70.7-0.7-1.51.9
Bone: stiffness0.10.10.8-0.00.0-0.00.0-0.10.10.20.00.1-0.0-0.20.2-0.3-0.70.9
Tibialis anterior weight1.24.15.52.32.3-2.3-2.32.2-2.2-2.12.32.2-2.32.0-1.81.70.60.6
Time to tail flick, vehicle, before self-admin0.20.21.2-0.2-0.30.30.1-0.30.30.3-0.1-0.60.0-0.20.2-0.2-0.91.1
Time to tail flick, vehicle, after self-admin0.10.20.6-0.3-0.00.00.20.1-0.10.4-0.3-0.20.3-0.50.5-0.5-0.80.7
Time to tail flick, test, before self-admin1.51.52.81.21.2-1.2-1.71.4-1.4-1.11.51.1-1.61.3-1.00.90.7-0.1
Time to tail flick, test, after self-admin0.80.84.1-0.4-0.40.40.6-0.30.30.5-0.9-0.70.8-1.10.6-0.7-1.82.0
Delta time to tail flick, vehicle, before/after SA0.60.61.6-0.5-0.30.30.3-0.40.40.8-0.5-0.30.5-1.01.1-1.1-1.31.0
Delta time to tail flick, test, before/after SA3.33.05.3-1.6-1.61.62.0-1.51.51.6-2.2-1.42.3-2.21.5-1.4-1.81.4
Tibia length1.23.54.72.12.1-2.1-2.22.1-2.1-1.72.11.9-2.11.5-1.31.2-0.52.1
Ambulatory time before self-admin0.10.10.60.30.0-0.00.1-0.20.2-0.30.20.8-0.00.3-0.10.0-0.40.4
Ambulatory time after self-admin1.51.63.51.71.5-1.5-1.20.4-0.4-1.61.80.7-1.91.3-1.11.0-0.30.9
Bone: tissue strength1.00.91.21.01.1-1.1-1.11.0-1.0-0.91.00.9-1.11.0-1.01.00.40.3
Total heroin consumption2.73.27.7-1.5-1.91.91.5-1.11.11.6-1.3-1.21.3-1.82.2-2.2-2.82.5
Bone: trabecular number5.38.39.9-3.0-3.03.03.0-2.92.93.1-2.9-3.12.7-3.13.1-3.1-2.41.2
Bone: trabecular spacing1.11.42.61.41.3-1.3-1.41.4-1.4-1.21.21.6-1.00.9-0.80.7-0.21.0
Bone: trabecular thickness0.10.10.5-0.4-0.40.40.4-0.50.50.4-0.1-0.7-0.1-0.20.4-0.4-0.20.1
Bone: trabecular tissue density0.50.74.20.00.2-0.2-0.20.3-0.3-0.40.00.0-0.00.6-0.91.01.9-2.0
Water consumed over 24 hours0.10.10.30.2-0.30.3-0.20.1-0.1-0.20.40.1-0.50.4-0.20.2-0.20.6
Number of responses in last shaping day0.60.61.8-0.5-0.80.80.8-0.80.80.3-0.9-1.00.8-0.40.3-0.20.9-1.4