Igflr1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver alternative TSS XM_039087351.1 0.06 0.04 4.6e-03 0.02 0.02 0.02 0.02 5.1e-03 5.4e-03 5.6e-03 5.2e-03
2 Brain isoform ratio XM_039087354.1 0.02 0.02 3.3e-03 0.02 0.03 0.02 0.01 7.4e-03 9.0e-04 3.3e-03 2.8e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density0.71.21.80.7-1.3
Area under the delay curve0.30.30.50.7-0.2
BMI with tail0.10.40.7-0.20.8
BMI without tail0.00.10.1-0.3-0.2
Body weight2.29.213.62.2-3.7
Weight adjusted by age0.30.30.40.6-0.5
Bone surface1.83.23.41.9-1.7
Bone volume1.93.23.31.7-1.8
Breakpoint value in progressive ratio session1.01.11.61.3-0.8
Number of licking bursts2.02.44.6-0.52.1
Context. condit. distance diff. score0.40.51.01.00.2
Locomotion velocity, session 10.10.20.30.10.6
Locomotion distance, session 13.14.07.52.7-0.7
Locomotion velocity, session 20.40.51.0-0.01.0
Locomotion distance, session 22.43.34.42.11.5
Locomotion velocity, session 30.50.60.80.90.5
Locomotion distance, session 36.87.413.13.6-1.3
Stereotopy head waving bouts, day 32.42.85.3-2.30.6
Stereotopy head waving duration, day 32.73.25.2-2.31.1
Locomotion velocity, session 71.81.93.71.9-0.5
Locomotion distance, session 71.01.32.41.6-0.5
Stereotopy head waving bouts, day 71.01.11.8-0.61.4
Stereotopy head waving duration, day 72.02.53.3-1.31.8
Locomotion velocity, session 82.32.85.50.32.3
Locomotion distance, session 82.33.45.22.31.2
Degree of sensitization distance1.91.93.7-1.90.4
Degree of sensitization stereotypy1.11.22.2-0.31.5
Conditioned locomotion0.70.91.1-0.81.1
Cocaine response after cond. corrected1.61.83.7-1.90.0
Cocaine response after cond. not corrected2.22.44.8-2.2-0.2
Cocaine response before conditioning0.81.01.50.6-1.2
Saline control response0.00.00.0-0.2-0.1
Bone: connectivity density0.30.50.60.8-0.7
Bone: cortical apparent density1.01.32.40.51.5
Bone: cortical area1.01.52.30.8-1.5
Bone: cortical porosity1.41.53.00.11.7
Bone: cortical porosity1.71.93.70.21.9
Bone: cortical thickness0.20.30.6-0.2-0.8
Bone: cortical thickness0.40.50.5-0.70.7
Bone: cortical tissue density1.21.52.80.51.7
Condit. Reinf. active minus inactive responses0.20.20.30.30.5
Condit. Reinf. active-inactive response ratio0.40.50.9-0.90.3
Condit. Reinf. active responses1.31.63.10.21.8
Condit. Reinf. inactive responses1.92.33.71.01.9
Incentive salience index mean0.40.40.50.70.6
Condit. Reinf. lever presses0.40.50.91.00.3
Condit. Reinf. active minus inactive responses1.51.92.31.5-1.2
Condit. Reinf. active-inactive response ratio0.10.10.10.30.1
Condit. Reinf. active responses3.04.14.32.1-2.0
Condit. Reinf. inactive responses3.03.73.81.9-1.9
Condit. Reinf. lever presses5.77.79.72.4-3.1
Condit. Reinf. lever reinforcers received3.65.16.22.5-2.0
Conditioned reinforcement - actives0.10.10.30.10.5
Conditioned reinforcement - inactives2.83.16.22.5-0.1
Conditioned locomotion1.62.03.90.02.0
Patch foraging indifference point 0 sec0.00.10.10.4-0.1
Patch foraging indifference point AUC0.40.50.6-0.80.6
Delay disc. indifference point, 0s delay2.02.24.42.10.1
Delay disc. indifference point, 16s delay0.30.30.50.7-0.4
Delay disc. indifference point, 2s delay2.42.74.72.2-0.8
Delay disc. indifference point, 24s delay2.12.02.31.5-1.3
Delay disc. indifference point, 4s delay0.30.30.30.60.6
Delay disc. indifference point, 8s delay0.00.00.1-0.1-0.3
Indifference point function ln k0.91.32.11.5-0.7
Indifference point function log k0.91.32.11.5-0.7
Patch foraging total patch changes 0 sec0.10.20.30.5-0.3
Patch foraging total patch changes 12 sec0.20.20.3-0.60.3
Patch foraging total patch changes 18 sec0.00.00.0-0.10.2
Patch foraging total patch changes 24 sec0.70.80.80.9-0.9
Patch foraging total patch changes 6 sec0.00.00.0-0.2-0.0
Patch foraging time to switch 0 sec2.74.27.6-2.80.9
Patch foraging water rate 0 sec0.91.51.81.31.0
Patch foraging water rate 12 sec1.52.44.22.0-0.8
Patch foraging water rate 18 sec0.30.40.50.70.5
Patch foraging water rate 24 sec4.05.611.13.30.3
Patch foraging water rate 6 sec3.65.39.63.1-1.0
Seeking ratio, delayed vs. immediate footshock1.82.13.31.8-0.9
Distance traveled before self-admin0.00.10.1-0.30.1
Distance traveled after self-admin2.32.53.61.2-1.9
Extensor digitorum longus weight0.10.40.7-0.80.0
Bone: elastic displacement0.40.40.8-0.9-0.1
Bone: elastic work1.01.32.60.3-1.6
Bone: endosteal estimation1.43.13.31.7-1.8
Bone: endosteal perimeter1.32.73.01.7-1.6
Epididymis fat weight0.40.91.51.2-0.5
Delta time in closed arm before/after self-admin2.12.03.50.8-1.9
Delta time in open arm before/after self-admin0.50.50.6-0.70.8
Diff in mean of infusions in LGA sessions0.60.61.0-0.51.0
Delay discount exponential model param0.20.30.4-0.60.3
Extinction: sum of active levers before priming2.22.24.40.3-2.1
Active lever presses in extinction session 62.22.13.5-0.9-1.9
Bone: final force1.32.22.81.2-1.7
Bone: final moment1.82.83.81.4-1.9
Food consumed during 24 hour testing period1.51.83.31.8-0.6
Glucose0.40.61.2-1.10.2
Heart weight1.52.14.12.0-0.3
Delay discount hyperbolic model param0.30.30.6-0.80.3
Intermittent access intake day 1-15 change2.12.13.01.0-1.7
Intermittent access intake escalation2.32.32.91.3-1.7
Intermittent access intake escalation 21.01.01.90.1-1.4
Intermitt. access day 1 inactive lever presses1.71.83.00.8-1.7
Intermitt. access day 15 inactive lever presses0.70.81.41.2-0.3
Intermitt. access escalation Index0.30.30.40.60.4
Intermittent access day 1 total infusions1.92.24.10.62.0
Intermittent access day 15 total infusions1.41.52.81.70.5
Intermittent access terminal intake (last 3 days)1.21.31.61.31.0
Intermittent access total infusions1.21.31.51.01.2
Intermittent access day 1 locomotion1.71.82.41.11.6
Intermittent access day 15 total locomotion1.81.93.71.90.4
Intermittent access total locomotion1.21.42.50.61.6
Intermittent access standard deviation3.43.64.41.6-2.1
Left kidney weight2.36.311.61.0-3.4
Right kidney weight3.911.018.41.9-4.3
Cocaine induced anxiety0.30.40.60.3-0.8
Post-drug Anxiety0.40.50.9-1.00.3
Baseline Anxiety1.21.31.8-0.91.4
Tail length3.19.315.91.6-4.0
Length with tail6.122.432.73.5-5.7
Length without tail5.512.113.73.2-3.7
Times rat made contact with spout0.20.20.3-0.50.3
Lifetime Intake0.91.01.40.81.2
Liver weight, left0.40.61.0-1.00.4
Liver weight, right0.00.10.1-0.10.3
Locomotor activity0.60.91.5-1.20.6
Locomotor testing distance0.30.50.7-0.80.6
Locomotor testing rearing0.81.22.3-0.41.5
Locomotion in novel chamber0.60.71.0-1.00.6
Locomotion in novel chamber post-restriction0.10.10.2-0.50.2
Fecal boli incidents, locomotor time 12.52.82.8-1.71.7
Change in fecal boli incidents, locomotor task0.70.71.1-1.1-0.5
Time >=10cm from walls, locomotor time 10.10.10.1-0.30.1
Bouts of movement, locomotor time 12.02.14.22.0-0.3
Total resting periods, locomotor time 11.21.32.51.6-0.2
Rest time, locomotor task time 11.21.31.5-1.11.2
Distance moved, locomotor task time 10.40.40.70.8-0.4
Vertical activity count, locomotor time 12.02.12.21.4-1.5
Time >=10cm from walls, locomotor time 21.41.52.5-0.61.6
Bouts of movement, locomotor time 20.10.10.10.40.1
Total resting periods, locomotor time 20.10.10.1-0.00.3
Rest time, locomotor task time 20.80.90.9-1.00.9
Distance moved, locomotor task time 20.60.71.41.20.1
Vertical activity count, locomotor time 21.81.93.01.7-0.9
Light reinforcement 10.20.30.30.50.5
Light reinforcement 21.31.83.5-0.01.9
Bone: marrow area1.42.93.41.6-1.9
Bone: maximum diameter1.01.92.71.0-1.6
Bone: maximum force2.34.04.71.8-2.2
Bone: maximum moment2.84.75.71.9-2.4
Mean time between licks in bursts0.40.61.11.00.2
Mean num. licks in bursts1.21.42.70.3-1.6
Cd content in liver0.40.50.8-0.9-0.4
Co content in liver0.60.71.1-1.10.5
Cu content in liver0.60.70.70.8-0.8
Fe content in liver0.10.10.2-0.40.2
K content in liver0.00.00.00.00.1
Mg content in liver0.40.40.7-0.40.8
Mn content in liver1.82.13.0-1.71.1
Na content in liver1.71.82.61.6-1.0
Rb content in liver0.20.20.20.40.4
Se content in liver4.75.88.7-1.73.0
Sr content in liver1.61.52.2-1.50.9
Zn content in liver0.00.00.10.10.3
Bone: minimum diameter2.54.64.92.2-2.1
Time in familiar zone, hab. session 10.80.81.20.6-1.1
Time in novel zone, hab. session 11.71.62.7-0.71.7
Total zone transitions, hab. session 10.81.12.11.40.2
Total locomotion distance, hab. session 10.30.50.50.6-0.7
Locomotion velocity, hab. session 10.10.20.30.1-0.6
Time in familiar zone, hab. session 21.41.42.0-0.9-1.4
Time in novel zone, hab. session 20.60.61.20.31.1
Total zone transitions, hab. session 22.02.65.10.42.3
Total locomotion distance, hab. session 20.30.40.70.40.8
Locomotion velocity, hab. session 20.30.40.80.20.9
Novel to familiar place preference ratio0.10.10.10.3-0.3
Novelty place preference0.10.10.10.3-0.1
Time in novel zone, NPP test0.10.10.10.30.1
Total zone transitions, NPP test0.50.61.21.10.2
Total locomotion distance, NPP test1.31.82.80.9-1.7
Locomotion velocity, NPP test1.21.72.90.7-1.7
Intraocular pressure0.10.20.3-0.60.3
Delta distance traveled before/after self-admin3.53.85.11.6-2.3
Delta ambulatory time before/after self-admin4.24.65.91.8-2.4
Parametrial fat weight1.12.14.0-2.0-0.4
Pavlov. Cond. lever latency0.40.50.6-0.6-0.8
Pavlov. Cond. magazine entry latency0.40.51.00.11.0
Pavlov. Cond. change in total contacts1.21.31.61.21.1
Pavlov. Cond. index score0.60.71.40.21.2
Pavlov. Cond. latency score0.50.60.90.51.0
Pavlov. Cond. lever contacts0.20.20.40.60.3
Pavlov. Cond. magazine entry number0.50.71.3-0.3-1.1
Pavlov. Cond. intertrial magazine entries0.40.50.70.50.8
Pavlov. Cond. lever-magazine prob. diff.0.70.91.70.31.3
Pavlov. Cond. response bias0.20.20.40.00.7
Pavlov. Cond. lever latency4.86.56.8-2.62.5
Pavlov. Cond. magazine entry latency1.92.22.41.4-1.6
Pavlov. Cond. change in total contacts6.99.510.03.0-3.2
Pavlov. Cond. index score4.76.06.22.5-2.4
Pavlov. Cond. latency score4.45.45.82.4-2.3
Pavlov. Cond. lever contacts4.56.26.72.6-2.4
Pavlov. Cond. magazine entry number3.94.84.8-2.22.2
Pavlov. Cond. intertrial magazine entries1.41.82.7-1.60.9
Pavlov. Cond. lever-magazine prob. diff.4.45.75.82.3-2.4
Pavlov. Cond. response bias5.67.68.93.0-2.5
Time in closed arm before self-admin1.82.03.8-0.52.0
Time in closed arm after self-admin0.00.00.00.10.0
Time in open arm before self-admin2.83.05.70.5-2.4
Time in open arm after self-admin0.70.81.50.3-1.2
Bone: periosteal estimation1.73.64.41.6-2.1
Bone: periosteal perimeter0.71.22.10.5-1.4
Bone: post-yield work2.73.75.82.4-1.3
Progressive ratio test 1 active lever presses1.51.63.11.8-0.2
Progressive ratio test 1 breakpoint1.41.52.71.6-0.5
Progressive ratio test 1 inactive lever presses2.22.44.82.2-0.1
Progressive ratio test 2 active lever presses1.01.12.01.40.3
Progressive ratio test 2 breakpoint0.80.91.61.30.4
Progressive ratio test 2 inactive lever presses3.03.57.02.60.1
Incentive Sensitization - Responses0.50.50.91.00.4
Incentive Sensitization - Breakpoint0.40.40.80.90.3
Sum of active levers in priming session hrs 5-60.10.10.20.2-0.4
Progressive ratio0.00.00.0-0.20.2
Food seeking constrained by brief footshock1.72.13.01.1-1.7
Seeking ratio, punishment vs. effort0.91.11.71.3-0.8
Retroperitoneal fat weight1.03.24.1-2.01.5
Reaction time number correct0.10.10.20.5-0.1
Reaction time mean minus median0.40.50.9-0.4-0.9
Reaction time mean minus median AUC0.81.02.0-0.2-1.4
Reaction time num false alarms0.81.11.2-1.11.0
Reaction time num false alarms AUC1.21.61.8-1.31.2
Reaction time trials correct on left0.10.10.20.5-0.1
Reaction time trials on left0.10.10.20.5-0.1
Reaction time mean0.20.30.40.4-0.6
Reaction time mean AUC0.10.10.20.1-0.5
Median of all reaction times0.10.10.20.5-0.3
Reaction time omissions0.20.20.5-0.7-0.1
Reaction time false alarm rate1.01.41.7-1.31.0
Reaction time premature initiation rate0.10.10.10.30.3
Reaction time premature initiations0.10.20.30.50.2
Std. dev. reaction times0.50.71.30.4-1.1
Reaction time trials completed0.10.10.20.5-0.1
Reaction time trials AUC0.00.00.00.2-0.1
Run reversals in cocaine runway, females1.31.31.81.4-0.9
Run reversals in cocaine runway, males2.12.14.1-2.0-0.2
Latency to leave start box in cocaine runway0.80.81.51.2-0.4
Latency to leave start box in cocaine runway, F1.11.22.41.5-0.0
Latency to leave start box in cocaine runway, M0.30.30.6-0.7-0.3
Std. dev. time between licks in bursts0.50.61.11.10.3
Total sessions with >9 infusions0.60.71.3-0.21.1
Short access day 1 total inactive lever presses2.52.85.52.30.3
Short access day 10 total inactive lever presses1.31.51.91.4-1.0
Short access day 1 total infusions0.80.81.51.20.4
Short access day 10 total infusions0.30.30.6-0.10.8
Short access total infusions0.50.61.10.11.1
Short access day 1 locomotion0.10.10.20.10.5
Short access day 10 total locomotion0.50.61.11.0-0.3
Short access total locomotion0.70.71.4-0.21.2
One hour access (0.3 mA shock)2.63.05.82.4-0.4
Compulsive drug intake0.30.30.70.8-0.2
One hour access (shock baseline)0.60.71.21.10.3
Social response proportion1.21.31.80.9-1.3
Social responses0.20.30.40.4-0.6
Social time4.15.47.62.8-1.8
Soleus weight0.00.10.1-0.40.3
Bone: stiffness1.52.32.51.6-1.5
Tibialis anterior weight0.20.81.5-1.2-0.4
Time to tail flick, vehicle, before self-admin0.60.61.20.21.1
Time to tail flick, vehicle, after self-admin0.80.91.6-1.30.3
Time to tail flick, test, before self-admin2.52.44.52.10.6
Time to tail flick, test, after self-admin0.10.10.30.50.1
Delta time to tail flick, vehicle, before/after SA0.50.50.6-0.8-0.6
Delta time to tail flick, test, before/after SA2.01.83.5-1.90.1
Tibia length3.49.59.63.1-3.1
Ambulatory time before self-admin0.10.20.2-0.50.3
Ambulatory time after self-admin5.05.57.02.0-2.6
Bone: tissue strength3.02.92.91.7-1.7
Total heroin consumption0.30.40.70.8-0.3
Bone: trabecular number2.13.33.92.0-1.6
Bone: trabecular spacing1.01.42.6-1.6-0.3
Bone: trabecular thickness0.60.71.41.2-0.1
Bone: trabecular tissue density3.14.47.1-2.71.3
Water consumed over 24 hours1.11.32.01.4-0.8
Number of responses in last shaping day1.51.52.71.60.6